CN103110805A - Traditional Chinese medicine composition for treating manic episodes caused by mood disorders and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating manic episodes caused by mood disorders and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating manic episodes caused by mood disorders and a preparation method thereof. The traditional Chinese medicine composition is prepared from radix astragali, radix codonopsis pilosulae, radix salviae miltiorrhizae, poria cocos, fructus schisandrae, radix polygalae, platycodon roots, angelica sinensis, radix glehniae, radix ophiopogonis, platycladi seeds, spina date seeds, radix rehmanniae recen, magnetite, concha haliotidis and born licorice in a certain weight ratio. The traditional Chinese medicine composition has the effects of clearing away the heart-fire, relieving restlessness, and calming the heart and nerves and can effectively treat manic episodes caused by mood disorders.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, be specifically related to a kind of mood disorders for the treatment of and cause Chinese medicine composition of maniac access and preparation method thereof.
Background technology
Mood disorders is one group of disease take remarkable and lasting emotion or mood alteration as principal character.Main manifestations is elation or low clinically, with corresponding cognition and behavior change, but spiritedness sexually transmitted disease (STD) disease, as hallucination, vain hope.Most patient has the tendency of outbreak repeatedly, and part can have residual condition of illness or transfer to chronic.Mood disorders comprises several types such as two-phase obstacle, maniac access and paralepsy, persistent mood disorder etc.Mood disorders causes maniac access mainly with in high spirits, easy excitation, and it is main exaggerating etc.Unbecoming with residing circumstances, can be in high spirits, excited uneasy, self evaluation is too high, and is intense, and disturbance of consciousness even occurs, and coordinating or the psychotic symptoms such as inharmonic hallucination, vain hope with mental state can appear in severe patient.Adopt clinically at present the chemotherapy maniac accesses such as lithium carbonate, but the toxic and side effects of its chemicals is larger, not welcome by the patient more.And Chinese medicine has been obtained greater advance, compares with western medicine, and toxic and side effects is few, and double taking stopgap measures originally easily accepted by the patient.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine composition, this Chinese medicine composition causes maniac access for the treatment mood disorders and has determined curative effect, the characteristics that have no side effect.
The present invention selects the Radix Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae, Poria, Fructus Schisandrae Chinensis, Radix Polygalae, Radix Platycodonis, Radix Angelicae Sinensis, Radix Glehniae, Radix Ophiopogonis, Semen Platycladi, Semen Ziziphi Spinosae, Radix Rehmanniae, Magnetitum, Concha Haliotidis, Radix Glycyrrhizae to make up, make each efficacy of drugs produce synergism these drug regimens, make it to have the relieving restlessness of clearing away heart-fire, the effect of mind tranquilizing and the heart calming causes maniac access thereby can effectively treat mood disorders.
The effect of Chinese medicine of the present invention:
Wherein:
The Radix Astragali: be the root of leguminous herbaceous plant's Radix Astagali, Radix Astragali.Nature and flavor are sweet, tepor.Return lung, spleen, liver, kidney channel.Effect: benefiting QI for strengthening the superficies, arresting sweating take off, hold in the palm skin ulcer granulation promoting, inducing diuresis to remove edema admittedly.
Radix Codonopsis: be the dry root of Campanulaceae Radix Codonopsis Codonopsis pilosula (Franch.) Nannf., element flower Radix Codonopsis Codonopsis pilosula Nannf.var.modesta (Nannf.) L.T.Shen or radix codonpsis tangshen Codonopsis tangshen Oliv..Nature and flavor are flat, sweet, little acid.Return spleen, lung meridian.Effect: invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.Radix Codonopsis also has the effects such as Fructus Alpiniae Oxyphyllae, calmness, hypnosis, convulsion.
Radix Salviae Miltiorrhizae: be the dry root and rhizome of dicotyledon Labiatae Labiatae salvia Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge..Nature and flavor are bitter, are slightly cold.Enter the heart, Liver Channel.Effect: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind." the southern regions of the Yunnan Province book on Chinese herbal medicine ": reinforcing the heart sedate, calming heart and tranquilizing mind.Control forgetful punching seized with terror, palpitation with fear is insomnia.
Poria: be the dry sclerotia of On Polyporaceae Poria Poria cocos (Schw.) Wolf.Nature and flavor are sweet, light, and are flat.GUIXIN, lung, spleen, kidney channel.Effect: eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming.The Poria decoct has obvious sedation." modality ": " cure mainly the Ji Rou Shun muscle of throbbing with fear cautious, the dizziness agitation is controlled on the side.”
Fructus Schisandrae Chinensis: be the dry mature fruit of magnoliaceae schisandra Schisandra chinensis (Turcz.) Baill..The nature and flavor temperature is sour, sweet.Return lung, the heart, kidney channel.Effect: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.Fructus Schisandrae Chinensis has obvious sedation and good sedative action to the central nervous system.
Radix Polygalae: be the dry root of milk wort Radix Polygalae Polygala tenuifolia Willd. or ovum leaf Radix Polygalae Polygala sibirica L..Nature and flavor are bitter, hot, tepor.GUIXIN, kidney, lung meridian.Effect: the Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, detumescence.The natural prerequisite medicine that contains TMCA in the Radix Polygalae water extract plays sedation.
Radix Platycodonis: be the dried roots of Campanulaceae Radix Platycodonis.Nature and flavor are bitter, hot, tepor.Enter lung meridian.Effect: open lung qi dispersing gas, the evacuation of pus of eliminating the phlegm.Kikyosaponin has calmness, analgesia and the central inhibitory action such as analgesic." herbal classic ": main chest and hypochondrium such as lancination, abdominal distention, borborygmus are faint, the gas of throbbing with fear in terror.
Radix Angelicae Sinensis: be the dry root of umbelliferae angelica Angelica sinensis (O1iv.) Diels.Nature and flavor are sweet, hot, bitter, temperature.Return liver, the heart, spleen channel.Effect: enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.Radix Angelicae Sinensis volatile oil has the effects such as calmness, hypnosis, analgesia, anesthesia to the central nervous system.
Radix Glehniae: be the dry root of samphire glehnia littoralis G1ehnia littoralis Fr.Schmidt ex Miq..Nature and flavor are sweet, little hardship, are slightly cold.Enter lung, spleen channel.Effect: nourishing YIN and clearing away lung-heat, reinforcing stomach reg fluid.
Radix Ophiopogonis: be the dried root of liliaceous plant Ophiopogon Radix Ophiopogonis japonicus (Thunb.) Ker-Gawl..Nature and flavor are sweet, little hardship, are slightly cold.GUIXIN, lung, stomach warp.Effect: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.Radix Ophiopogonis, decoct had sedation to the central nervous system, also can strengthen the sedation of chlorpromazine, strengthened the syngignoscism of pentobarbital sodium.
Semen Platycladi: be the dry mature kernal of Cupressaceae plant Cacumen Platycladi Platycladus orientalis (L.) Franco.Nature and flavor are sweet, and are flat.GUIXIN, kidney, large intestine channel.Effect: tranquilizing by nourishing the heart, loosening bowel to relieve constipation.Semen Platycladi has calmness, syngignoscism.Shennong's Herbal: " cypress is real, and sweet in the mouth is flat, main palpitation with fear, and settling five organs, QI invigorating, except rheumatism numbness, clothes make us moist, beauty, normal hearing and eyesight for a long time.”
Semen Ziziphi Spinosae: be the seed of Rhamnaceae plant Ziziphi Spinosae.Nature and flavor are sweet, sour, and are flat.GUIXIN, spleen, liver, gallbladder meridian.Effect: nourishing the liver, mind calming is calmed the nerves, arresting sweating.The calmness of Semen Ziziphi Spinosae water solubility extract, hypnosis, anticonvulsant action.
Radix Rehmanniae: be the root of dicotyledon medicine scrophulariaceae rehmannia glutinosa plant or bosom celebrating Radix Rehmanniae.Nature and flavor are sweet, bitter, and are cool.Enter the heart, liver, kidney channel.Effect: heat clearing away is nourished blood, the YIN nourishing of promoting the production of body fluid.Radix Rehmanniae has obvious sedation, and its site of action is at cerebral cortex, and its aqueous extract can suppress autonomic activities, and can strengthen the syngignoscism of HD pentobarbital sodium and penthiobarbital, also can resist the excitation of caffeine and sodium benzoate simultaneously.
Magnetitum: be the Ore of oxide-based mineral magnetic iron ore.Nature and flavor are hot, salty, and are flat; Nontoxic.Return kidney, liver, lung meridian.Function: suppressing the hyperactive liver and subsiding YANG; Calm the nerves relieving convulsion; Hearing-improing and eyesight improving; Helping inspiration to relieve asthma.Magnetitum has obvious calmness and anticonvulsant action.
Concha Haliotidis: be the shell of Bao Ke animal Haliotis diversicolor, haliotis discus hannai Ino, ear Bao, sheep Bao etc.Nature and flavor are salty, and are cold.Enter liver, kidney channel.Effect: calming liver and clearing heat, removing nebula makes eye bright." Shandong Chinese herbal medicine handbook: the town liver, make eye bright, control dizzy.
Radix Glycyrrhizae: be glycyrrhizic legume Glycyrrhiza uralensis Fisch., the dry root and rhizome of Glycyrrhiza inflata Bat. Glycyrrhiza Inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza Glabra L..Nature and flavor are sweet, and are flat.GUIXIN, lung, spleen, stomach warp.Effect: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription." Japan hanako materia medica ": the peace soul is decided soul.Mend five kinds of strain and seven kinds of impairment, all are deficient, palpitation with fear, unhappy, forgetful.Logical nine orifices, sharp hundred arteries and veins, beneficial intensive culture gas, strengthening bone and muscle is separated cold and hot.
Medicine material consumption of the present invention is groped to sum up to draw through the inventor in a large number, and each raw material consumption is for all to have curative effect preferably in the following weight parts scope: Radix Astragali 25-35 part, Radix Codonopsis 13-23 part, Radix Salviae Miltiorrhizae 20-28 part, Poria 10-20 part, Fructus Schisandrae Chinensis 7-17 part, Radix Polygalae 20-28 part, Radix Platycodonis 10-20 part, Radix Angelicae Sinensis 13-23 part, Radix Glehniae 15-25 part, Radix Ophiopogonis 13-23 part, Semen Platycladi 10-20 part, Semen Ziziphi Spinosae 25-35 part, Radix Rehmanniae 25-35 part, Magnetitum 25-35 part, Concha Haliotidis 25-35 part, Radix Glycyrrhizae 6-12 part.
Wherein be preferably: 30 parts of the Radixs Astragali, 18 parts of Radix Codonopsis, 24 parts of Radix Salviae Miltiorrhizaes, 15 parts, Poria, 12 parts of Fructus Schisandrae Chinensis, 24 parts of Radix Polygalaes, 15 parts of Radix Platycodoniss, 18 parts of Radix Angelicae Sinensis, 20 parts of Radix Glehniaes, 18 parts of Radix Ophiopogonis, 15 parts of Semen Platycladi, 30 parts of Semen Ziziphi Spinosaes, 30 parts of Radix Rehmanniae, 30 parts of Magnetitums, 30 parts of Concha Haliotidis, 9 parts of Radix Glycyrrhizae.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into decoction.
Step 1, at first first put into container according to weight proportion weighing Magnetitum, Concha Haliotidis and boiled 20 minutes.
Step 2, then put into the step 1 container according to the weight proportion weighing Radix Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae, Poria, Fructus Schisandrae Chinensis, Radix Polygalae, Radix Platycodonis, Radix Angelicae Sinensis, Radix Glehniae, Radix Ophiopogonis, Semen Platycladi, Semen Ziziphi Spinosae, Radix Rehmanniae, Radix Glycyrrhizae and fry in shallow oil and got final product in 25-30 minute.
Medicine of the present invention has the relieving restlessness of clearing away heart-fire, and the effects such as mind tranquilizing and the heart calming, and determined curative effect have no side effect, and according to clinical 30 routine patients are observed statistics, uses 80%, two of one of the medicine of the present invention total effective rate course for the treatment of total effective rate course for the treatment of 92%.
The specific embodiment
Embodiment one, 25 parts of the Radixs Astragali, 13 parts of Radix Codonopsis, 20 parts of Radix Salviae Miltiorrhizaes, 10 parts, Poria, 7 parts of Fructus Schisandrae Chinensis, 20 parts of Radix Polygalaes, 10 parts of Radix Platycodoniss, 13 parts of Radix Angelicae Sinensis, 15 parts of Radix Glehniaes, 13 parts of Radix Ophiopogonis, 10 parts of Semen Platycladi, 25 parts of Semen Ziziphi Spinosaes, 25 parts of Radix Rehmanniae, 25 parts of Magnetitums, 25 parts of Concha Haliotidis, 6 parts of Radix Glycyrrhizae.
Embodiment two, 30 parts of the Radixs Astragali, 18 parts of Radix Codonopsis, 24 parts of Radix Salviae Miltiorrhizaes, 15 parts, Poria, 12 parts of Fructus Schisandrae Chinensis, 24 parts of Radix Polygalaes, 15 parts of Radix Platycodoniss, 18 parts of Radix Angelicae Sinensis, 20 parts of Radix Glehniaes, 18 parts of Radix Ophiopogonis, 15 parts of Semen Platycladi, 30 parts of Semen Ziziphi Spinosaes, 30 parts of Radix Rehmanniae, 30 parts of Magnetitums, 30 parts of Concha Haliotidis, 9 parts of Radix Glycyrrhizae.
Embodiment three, 35 parts of the Radixs Astragali, 23 parts of Radix Codonopsis, 28 parts of Radix Salviae Miltiorrhizaes, 20 parts, Poria, 17 parts of Fructus Schisandrae Chinensis, 28 parts of Radix Polygalaes, 20 parts of Radix Platycodoniss, 23 parts of Radix Angelicae Sinensis, 25 parts of Radix Glehniaes, 23 parts of Radix Ophiopogonis, 20 parts of Semen Platycladi, 35 parts of Semen Ziziphi Spinosaes, 35 parts of Radix Rehmanniae, 35 parts of Magnetitums, 35 parts of Concha Haliotidis, 12 parts of Radix Glycyrrhizae.
The below is the clinical statistics data that the patient uses medicine of the present invention:
One, physical data
Accept patient's totally 30 examples for medical treatment, male's 8 examples wherein, women's 22 examples, M-F 0.4: 1,40 years old mean age.
Two, diagnostic criteria: take in high spirits or irritability as main, and have following three (if only be irritability, needing four at least) at least
1, absent minded or shift with the border.
2, the language amount increases.
3, flight of thought (word speed speeds, speech is urged etc.), association accelerate or the experience of flight of ideas.
4, self evaluation is too high or exaggerate.
5, energetic, do not feel tired, activity increases, be difficult to peace and quiet, or constantly change one's plans and movable.
6, crude and rash behavior (as spend freely, irresponsibility or the behavior of ignoring the possible consequences etc.).
7, sleep needs to reduce.
8, hypersexuality.
Three, Therapeutic Method
According to drug weight proportioning of the present invention, weighting raw materials (daily dose), decocting, filter and remove residue services once sooner or later, and 20 is a course for the treatment of.
Four, efficacy assessment standard
Cure: language, manner, look are all recovered normally, can the normal process routine matter.
Take a turn for the better: look stable, language, manner normal, or be improved.
Do not heal: language, manner, look are all without improving.
Five, therapeutic outcome statistics
Wherein: total effective rate=cure rate+improvement rate
Model case and curative effect:
Case one, Rui, the female, at 28 years old age, the patient states every day and will work before computer seven or eight hours at least, sometimes feels suddenly very irritated, baffledly flies into a rage rumly, indiscriminately gas is given vent to it the colleague.Unsatisfactory will the letting loose a stream of savage invective suddenly of sometimes working even clapped desk and clapped chair.The patient takes Chinese medicine of the present invention after course for the treatment of, and language, manner recover normal, can work, and healing.
Case two, Chen, female, patient age 58 years old.Recent months, is glowing with health on the face, and all day is in high spirits, often dresss up very bright-coloured obviously, and the shopping of liking going window-shopping is spent money extravagantly, and buys a little unpractical things, and words are a lot, runs into the people and speaks and always speak unceasingly, and full of vitality, evening is busy to after midnight.The patient takes Chinese medicine of the present invention after two courses for the treatment of, and look stable, language, manner normal, and symptom is obviously improved, and takes a turn for the better.
Case three, Wu, the man, at 31 years old age, the patient did not have the appearance of obvious cause excited before 20 days, and words are many, spend money extravagantly, and spent 20,000 yuan to go Xinhua Bookstore to buy book, buy back home to be deposited in family and not see.Liable to fits of temper, usually because some minor matters do not comply with one's wishes just flies into a rage, curse and beat the family members, household's advice is thought containing oneself, usually to go out to stay out, insomnia is disorderly thought.The patient takes Chinese medicine of the present invention after two courses for the treatment of, language, manner normal, and symptom is clearly better.
Claims (3)
1. treat the Chinese medicine composition that mood disorders causes maniac access for one kind, it is characterized in that, this Chinese medicine composition is the ingredients by following weight portion: Radix Astragali 25-35 part, Radix Codonopsis 13-23 part, Radix Salviae Miltiorrhizae 20-28 part, Poria 10-20 part, Fructus Schisandrae Chinensis 7-17 part, Radix Polygalae 20-28 part, Radix Platycodonis 10-20 part, Radix Angelicae Sinensis 13-23 part, Radix Glehniae 15-25 part, Radix Ophiopogonis 13-23 part, Semen Platycladi 10-20 part, Semen Ziziphi Spinosae 25-35 part, Radix Rehmanniae 25-35 part, Magnetitum 25-35 part, Concha Haliotidis 25-35 part, Radix Glycyrrhizae 6-12 part.
2. treatment mood disorders described according to claims 1 causes the Chinese medicine composition of maniac access, it is characterized in that, by the ingredients of following weight portion: 30 parts of the Radixs Astragali, 18 parts of Radix Codonopsis, 24 parts of Radix Salviae Miltiorrhizaes, 15 parts, Poria, 12 parts of Fructus Schisandrae Chinensis, 24 parts of Radix Polygalaes, 15 parts of Radix Platycodoniss, 18 parts of Radix Angelicae Sinensis, 20 parts of Radix Glehniaes, 18 parts of Radix Ophiopogonis, 15 parts of Semen Platycladi, 30 parts of Semen Ziziphi Spinosaes, 30 parts of Radix Rehmanniae, 30 parts of Magnetitums, 30 parts of Concha Haliotidis, 9 parts of Radix Glycyrrhizae.
3. cause the preparation method of the Chinese medicine composition of maniac access according to claims 1 or 2 described treatment mood disorders, it is characterized in that:
Step 1, at first first put into container according to weight proportion weighing Magnetitum, Concha Haliotidis and boiled 20 minutes.
Step 2, then put into the step 1 container according to the weight proportion weighing Radix Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae, Poria, Fructus Schisandrae Chinensis, Radix Polygalae, Radix Platycodonis, Radix Angelicae Sinensis, Radix Glehniae, Radix Ophiopogonis, Semen Platycladi, Semen Ziziphi Spinosae, Radix Rehmanniae, Radix Glycyrrhizae and fry in shallow oil and got final product in 25-30 minute.
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| CN104906493A (en) * | 2015-06-10 | 2015-09-16 | 徐如阳 | Chinese herba preparation for treating mania |
| CN105412662A (en) * | 2015-12-15 | 2016-03-23 | 许五妮 | Traditional Chinese medicine for treating manic schizophrenia |
| CN115671201A (en) * | 2021-07-28 | 2023-02-03 | 上海中医药大学附属龙华医院 | Traditional Chinese medicine plaster for treating premature beat |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104906493A (en) * | 2015-06-10 | 2015-09-16 | 徐如阳 | Chinese herba preparation for treating mania |
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| CN115671201A (en) * | 2021-07-28 | 2023-02-03 | 上海中医药大学附属龙华医院 | Traditional Chinese medicine plaster for treating premature beat |
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Application publication date: 20130522 |