Summary of the invention
Up to now, also do not find the report of any relevant pharmaceutical composition of the present invention, therefore still there is expectation in human Chinese medicine preparation to the early stage habitual abortion of curative effect better healing, the inventor is through repeatedly research, finally find the Chinese medicine preparation of the early stage habitual abortion for the treatment of of better efficacy, finished the present invention.The object of the invention provides little, the treating both the principal and secondary aspects of a disease of a kind of side effect, can more effectively treat the Chinese medicine preparation of early stage habitual abortion.
The consumption of ingredients part of the present invention is that inventor's process gropes to sum up to get for a long time in a large number, and the each component consumption all has preferably curative effect in following weight parts:
6~18 parts in Radix Rehmanniae Preparata, 20~60 parts of Semen Cuscutae, 12~36 parts of Fructus Corni, 20~60 parts of Herba Taxillis, 18~54 parts of Radix Dipsacis, 12~36 parts of Cortex Eucommiae (parched), 30~90 parts of the Radixs Astragali, 20~60 parts of Radix codonopsis pilosulae, 12~36 parts in Poria, 10~30 parts of Rhizoma Atractylodis Macrocephalae preparatas, 18~54 parts of Rhizoma dioscoreae (parched)s, 6~18 parts of Radix Angelicae Sinensis, 18~54 parts of Radix Paeoniae Alba (parched)s, 12~36 parts in Colla Corii Asini, 12~36 parts of Chinese toon root white skins.
Medicament selection Radix Rehmanniae Preparata of the present invention, Semen Cuscutae, Fructus Corni, Herba Taxilli, Radix Dipsaci, Cortex Eucommiae (parched), the Radix Astragali, Radix codonopsis pilosulae, Poria, Rhizoma Atractylodis Macrocephalae preparata, Rhizoma dioscoreae (parched), Radix Angelicae Sinensis, Radix Paeoniae Alba (parched), Colla Corii Asini, Chinese toon root white skin make up, with these drug regimens so that each efficacy of drugs produces synergism.Radix Rehmanniae Preparata, Semen Cuscutae, Fructus Corni, Herba Taxilli, Radix Dipsaci, Cortex Eucommiae (parched) the kidney warming are mended congenital kidney with solid feotus vitality in the side; The spleen of Radix codonopsis pilosulae, Poria, Rhizoma Atractylodis Macrocephalae preparata, Rhizoma dioscoreae (parched), Radix Angelicae Sinensis benefiting QI and nourishing blood benefit day after tomorrow is with the fetus nourishing body; The Radix Paeoniae Alba (parched) relieving spasm to stop pain; Colla Corii Asini, Chinese toon root white skin removing heat from blood, astringent or styptic treatment for spontaneous sweating, hemostasis.All medicine compatibilities are played altogether kidney and spleen invigorating, benefiting QI and nourishing blood, are admittedly rushed antiabortive effect.Modern pharmacological research proof Tu SIZI, parasitism, Radix Dipsaci etc. have short luteal function, promote the effect of Progesterone Secretion, can regulate and improve hormonal system, thereby promote the growth of uterus and fetus to send out; Radix codonopsis pilosulae, Poria, Rhizoma Atractylodis Macrocephalae preparata, the Cortex Eucommiae, the Radix Paeoniae Alba, the Radix Astragali etc. can suppress the uterine smooth muscle spontaneous contractions, and immunoregulation effect is arranged.
Take a broad view of full side, treating both the principal and secondary aspects of a disease, warm and not dry, tonify without causing stagnation.Compared with prior art, the present invention have letter, just, test, honest and clean, side effect is little, treating both the principal and secondary aspects of a disease, the patient is easy to accept, and can more effectively treat the advantage of early stage habitual abortion, clinic is applied.
The specific embodiment
The Chinese medicine preparation of the early stage habitual abortion for the treatment of of the present invention is to be made by the crude drug of following weight portion:
6~18 parts in Radix Rehmanniae Preparata, 20~60 parts of Semen Cuscutae, 12~36 parts of Fructus Corni, 20~60 parts of Herba Taxillis, 18~54 parts of Radix Dipsacis, 12~36 parts of Cortex Eucommiae (parched), 30~90 parts of the Radixs Astragali, 20~60 parts of Radix codonopsis pilosulae, 12~36 parts in Poria, 10~30 parts of Rhizoma Atractylodis Macrocephalae preparatas, 18~54 parts of Rhizoma dioscoreae (parched)s, 6~18 parts of Radix Angelicae Sinensis, 18~54 parts of Radix Paeoniae Alba (parched)s, 12~36 parts in Colla Corii Asini, 12~36 parts of Chinese toon root white skins.
The present invention takes by weighing according to the said medicine weight proportion, mixes, pulverizes, sieves, sterilizing, and wine is general to be made as ball such as Firmiana simplex seed is large; The present invention can also take by weighing according to the said medicine weight proportion, mixes, pulverizes, sieves, sterilizing, makes capsule.
Medicine major function of the present invention and therapeutic domain
1, major function:
Kidney and spleen invigorating, benefiting QI and nourishing blood, admittedly rush antiabortive.
2, therapeutic domain:
Be applicable to betide three months habitual abortions in the past.
3, usage and consumption
Each 9g, every day 2 times is from finding that the early pregnancy clothes were to pregnant three months.The period in a medicine nutrition that is careful in one's diet keeps happy, avoids overworked, prohibitive life.
Further set forth the beneficial effect of the Chinese medicine preparation of the early stage habitual abortion for the treatment of of the present invention below by test example, these test examples comprise the clinical observation on the therapeutic effect test of the Chinese medicine preparation of the early stage habitual abortion for the treatment of of the present invention.
[
Test example] clinical observation of Chinese medicine preparation of the early stage habitual abortion for the treatment of of the present invention
1, physical data
Accept outpatient service patient diagnosed 85 examples for medical treatment, the patient is divided into two groups at random, treatment group 45 examples give Drug therapy of the present invention, and wherein the age minimum is 30 years old, maximum 42 years old; The parity of previously miscarrying: 2 tires, 22 examples, 3 tires, 12 examples, 4 tires, 8 examples, 5 tires, 3 examples; The shortest 5 weeks in pregnant week, the longest 8 weeks; A small amount of colporrhagia 12 examples; Waist abdomen pain 20 examples; Asymptomatic 13 examples.Matched group 40 examples give the dydrogesterone treatment.Wherein the age minimum is 28 years old, maximum 40 years old; The parity of previously miscarrying: 2 tires, 20 examples, 3 tires, 12 examples, 4 tires, 6 examples, 5 tires, 2 examples; The shortest 6 weeks in pregnant week, the longest 8 weeks; A small amount of colporrhagia 13 examples; Waist abdomen pain 17 examples; Asymptomatic 10 examples.Two groups of patients learn processing by statistics at aspects such as age, parity, pregnant week, clinical symptoms, without significant difference (t check, P value<0.5), have comparability.
2, diagnostic criteria
The card Standardization of diagnosis and curative effect of curing the desease among People's Republic of China's Chinese medicine industry standard of all cases with reference to State Administration of Traditional Chinese Medicine's issue is determined diagnosis.
3, Therapeutic Method
Therapeutic Method is under the voluntary prerequisite of patient, the patient is divided into two groups at random, and treatment group 45 examples are taken Drug therapy of the present invention, each 9g, and every day 2 times is oral.Matched group 40 examples are taken dydrogesterone treatment, each 10mg, and every day 2 times is oral.More than treatment is all from finding that the early pregnancy clothes were to pregnant three months.
4, efficacy assessment standard criterion of therapeutical effect:
Recovery from illness: clinical symptom disappearance, the ultrasound diagnosis fetal development is normal, and through following up a case by regular visits to, gestation reached more than 28 weeks, or the intrauterine pregnancy,delivered normal infant.
Produce effects: clinical symptoms obviously alleviates, and the ultrasound diagnosis fetal development is normal, and gestation reached more than 28 weeks.
Take a turn for the better: clinical symptoms makes moderate progress, and the ultrasound diagnosis fetal development is normal.
Invalid: clinical symptoms increases the weight of after the treatment, and the ultrasound diagnosis embryo stops to send out or educating dysplasia, stops before 28 weeks in original pregnant month miscarriage or gestation.
5. results and analysis (seeing Table 1)
Table 1 liang group curative effect relatively
The treatment group curative effect obviously is better than matched group as can be seen from Table 1, and its total effective rate (91.1%) is apparently higher than matched group (75%).
Model case:
Example 1. Liu, the woman, 31 years old, the explosion-proof producer in Nanyang belonged to institute.First visit on May 20 in 2006.Readme once had history of spontaneous abortion 2 times, all at pregnant about 50 days.Existing menolipsis 40 days, chemical examination urine HCG(+), sense waist abdomen pendant pain has a small amount of vaginal hemorrhage.The B ultrasonic prompting is in utero pregnant.Diagnosis: 1. habitual abortion 2. threatened abortions.Give drug oral of the present invention, transference cure after 1 week, the check visible tire bud of B ultrasonic and primitive heart tube are beaten after two weeks.Continued clothes to pregnant 3 months, and ultrasound diagnosis prompting fetal development meets pregnant week.Drug withdrawal is followed up a case by regular visits to after 1 year and is cutd open the palace on February 10th, 2007 and produce childbirth one boy baby that lives.
Example 2. mountains, woman, 35 years old, the little family members in Nanyang eight institute.First visit on July 20 in 2006.Readme once had history of spontaneous abortion 3 times, all at pregnant about 40 days.Existing menolipsis 38 days, chemical examination urine HCG(+), the B ultrasonic prompting is in utero pregnant.Diagnosis: habitual abortion.Give drug oral of the present invention, clothes were to pregnant 3 months, and ultrasound diagnosis prompting fetal development is normal.Drug withdrawal is followed up a case by regular visits to after 1 year in suitable childbirth one boy baby alive on April 24th, 2007.
Example 3. high certain, woman, 38 years old, No. 23, Memorial Temple to Medical Sage street, Nanyang.First visit on August 20 in 2007.Readme once had history of spontaneous abortion 2 times, all at pregnant about 50 days.Existing menolipsis 34 days, chemical examination urine HCG(+), sense waist abdomen pendant pain.Diagnosis: 1. habitual abortion 2. threatened abortions.Give drug oral of the present invention, transference cure after 1 week, the B ultrasonic prompting is in utero pregnant.Continued clothes to pregnant 3 months, and ultrasound diagnosis prompting fetal development meets pregnant week.Drug withdrawal is followed up a case by regular visits to after 1 year in premature labor on April 20 in 2008 one girl baby alive.
Example 4. neat certain, woman, 35 years old, Nanyang medicine all No. 18.First visit on January 13 in 2008.Readme once had history of spontaneous abortion 3 times, all about pregnant February.Existing menolipsis 52 days, chemical examination urine HCG(+), the B ultrasonic prompting is in utero pregnant.Soreness of waist stomachache appears in cause fatigue in a day.Diagnosis: 1. habitual abortion 2. threatened abortions.Give drug oral of the present invention, sx↓ after 1 week, transference cure after two weeks, the check visible tire bud of B ultrasonic and primitive heart tube are beaten.Continued clothes to pregnant 3 months, and ultrasound diagnosis prompting fetal development is normal.Drug withdrawal is followed up a case by regular visits to after 1 year and is cutd open the palace on October 22nd, 2008 and produce childbirth one girl baby that lives.
Example 5. Guo, woman, 40 years old, Xinhua Lu, Nanyang this mansion of agate.JIUYUE in 2008 first visit on the 10th.Readme once had history of spontaneous abortion 4 times, all about pregnant February.Once did the inspections such as chromosome, blood group, agnogenio.Existing menolipsis 42 days, chemical examination urine HCG(+), the B ultrasonic prompting is in utero pregnant.Diagnosis: habitual abortion.Give drug oral of the present invention, the check visible tire bud of B ultrasonic and primitive heart tube are beaten after two weeks.Continued clothes to pregnant 3 months, and ultrasound diagnosis prompting fetal development is normal.Patient age is large, and history of spontaneous abortion is once arranged 4 times, continues to take and consolidates curative effect January.Follow up a case by regular visits to after 1 year, give birth to a girl baby alive on May 2nd, 2009 because of the premature rupture of fetal membrane premature labor.
Example 6. Zhangs, woman, 42 years old, family members institute of Nanyang Local Tax Bureau.First visit on May 13 in 2008.Readme once had history of spontaneous abortion 3 times, all about pregnant 6 weeks.Existing menolipsis 34 days, chemical examination urine HCG(+).Have hemorrhage on a small quantity, the coffee sample.Diagnosis: 1. habitual abortion 2. threatened abortions.Give drug oral of the present invention, stopped bleeding after 1 week, the clothes that continue were to pregnant 3 months, and ultrasound diagnosis prompting fetal development is normal.Drug withdrawal was followed up a case by regular visits to after 1 year, cutd open the palace on February 10th, 2009 and produced childbirth one boy baby alive.
Example 7. rivers, woman, 36 years old, family members institute of Nanyang Alcohol Plant.First visit on March 10 in 2008.Readme once had history of spontaneous abortion 2 times, all at pregnant about 40 days.Existing menolipsis 35 days, chemical examination urine HCG(+).Diagnosis: habitual abortion.Give drug oral of the present invention, the check visible tire bud of B ultrasonic and primitive heart tube are beaten after 3 weeks.Continued clothes to pregnant 3 months, and ultrasound diagnosis prompting fetal development is normal.Follow up a case by regular visits to after 1 year, cutd open the palace on the 15th in December in 2008 and produce childbirth one girl baby alive.
Example 8. Liu, woman, 32 years old, Wolong District Xie village, Nanyang village people.First visit on April 25 in 2009.Readme once had history of spontaneous abortion 3 times, all at pregnant about 50 days.Existing menolipsis 40 days, chemical examination urine HCG(+), the B ultrasonic prompting is in utero pregnant.Diagnosis: habitual abortion.Give drug oral of the present invention, clothes were to pregnant 3 months, and ultrasound diagnosis prompting fetal development is normal.Follow up a case by regular visits to after 1 year, in suitable childbirth one girl baby alive on February 5th, 2010.
Example 9. Zhangs, woman, 38 years old, Wancheng District Huang Tai people from hilllock, Nanyang.First visit on March 15 in 2008.Readme once had history of spontaneous abortion 3 times, all about pregnant 5 weeks.Existing menolipsis 43 days, chemical examination urine HCG(+), the ultrasound diagnosis prompting is in utero pregnant.The sense lumbago has hemorrhage on a small quantity in the time of over 2 days.Diagnosis: 1. habitual abortion 2. threatened abortions.Give drug oral of the present invention, stopped bleeding after 1 week, 2 all low back alleviation of pain are light, and the check visible tire bud of B ultrasonic and primitive heart tube are beaten.Continued clothes to pregnant 3 months, and ultrasound diagnosis prompting fetal development is normal.Follow up a case by regular visits to after 1 year, cutd open the palace on the 10th in December in 2008 and produce childbirth one girl baby alive.
Example 10. Zhangs, woman, 41 years old, Wancheng District Wa Dian people from town, Nanyang.First visit on January 18 in 2008.Readme marry 8 years infertile, once made test-tube baby, all in spontaneous abortion in pregnant February.1 week after this embryo implants, prevent miscarriage in hospital, require to take traditional Chinese medicine treatment.Diagnosis: 1. habitual abortion.Give drug oral of the present invention, clothes were to pregnant 3 months, and ultrasound diagnosis prompting fetal development is normal.Continue to take and consolidate curative effect February.Follow up a case by regular visits to after 1 year, cut open the palace on October 2nd, 2008 and produce childbirth one girl baby alive.
Further specify the Chinese medicine preparation of the early stage habitual abortion for the treatment of of the present invention below by embodiment.
Embodiment 1:
The Chinese medicine preparation of the early stage habitual abortion for the treatment of of the present invention is to be made by the crude drug of following weight portion:
6 parts in Radix Rehmanniae Preparata, 20 parts of Semen Cuscutae, 12 parts of Fructus Corni, 20 parts of Herba Taxillis, 18 parts of Radix Dipsacis, 12 parts of Cortex Eucommiae (parched), 30 parts of the Radixs Astragali, 20 parts of Radix codonopsis pilosulae, 12 parts in Poria, 10 parts of Rhizoma Atractylodis Macrocephalae preparatas, 18 parts of Rhizoma dioscoreae (parched)s, 6 parts of Radix Angelicae Sinensis, 18 parts of Radix Paeoniae Alba (parched)s, 12 parts in Colla Corii Asini, 12 parts of Chinese toon root white skins.
Embodiment 2:
The Chinese medicine preparation of the early stage habitual abortion for the treatment of of the present invention is to be made by the crude drug of following weight portion:
9 parts in Radix Rehmanniae Preparata, 30 parts of Semen Cuscutae, 18 parts of Fructus Corni, 30 parts of Herba Taxillis, 27 parts of Radix Dipsacis, 18 parts of Cortex Eucommiae (parched), 45 parts of the Radixs Astragali, 30 parts of Radix codonopsis pilosulae, 18 parts in Poria, 15 parts of Rhizoma Atractylodis Macrocephalae preparatas, 27 parts of Rhizoma dioscoreae (parched)s, 9 parts of Radix Angelicae Sinensis, 27 parts of Radix Paeoniae Alba (parched)s, 18 parts in Colla Corii Asini, 18 parts of Chinese toon root white skins.
Embodiment 3:
The Chinese medicine preparation of the early stage habitual abortion for the treatment of of the present invention is to be made by the crude drug of following weight portion:
12 parts in Radix Rehmanniae Preparata, 40 parts of Semen Cuscutae, 24 parts of Fructus Corni, 40 parts of Herba Taxillis, 36 parts of Radix Dipsacis, 24 parts of Cortex Eucommiae (parched), 60 parts of the Radixs Astragali, 40 parts of Radix codonopsis pilosulae, 24 parts in Poria, 20 parts of Rhizoma Atractylodis Macrocephalae preparatas, 36 parts of Rhizoma dioscoreae (parched)s, 12 parts of Radix Angelicae Sinensis, 36 parts of Radix Paeoniae Alba (parched)s, 24 parts in Colla Corii Asini, 24 parts of Chinese toon root white skins.
Embodiment 4:
The Chinese medicine preparation of the early stage habitual abortion for the treatment of of the present invention is to be made by the crude drug of following weight portion:
15 parts in Radix Rehmanniae Preparata, 50 parts of Semen Cuscutae, 30 parts of Fructus Corni, 50 parts of Herba Taxillis, 45 parts of Radix Dipsacis, 30 parts of Cortex Eucommiae (parched), 75 parts of the Radixs Astragali, 50 parts of Radix codonopsis pilosulae, 30 parts in Poria, 25 parts of Rhizoma Atractylodis Macrocephalae preparatas, 45 parts of Rhizoma dioscoreae (parched)s, 15 parts of Radix Angelicae Sinensis, 45 parts of Radix Paeoniae Alba (parched)s, 30 parts in Colla Corii Asini, 30 parts of Chinese toon root white skins.
Embodiment 5:
The Chinese medicine preparation of the early stage habitual abortion for the treatment of of the present invention is to be made by the crude drug of following weight portion:
18 parts in Radix Rehmanniae Preparata, 60 parts of Semen Cuscutae, 36 parts of Fructus Corni, 60 parts of Herba Taxillis, 54 parts of Radix Dipsacis, 36 parts of Cortex Eucommiae (parched), 90 parts of the Radixs Astragali, 60 parts of Radix codonopsis pilosulae, 36 parts in Poria, 30 parts of Rhizoma Atractylodis Macrocephalae preparatas, 54 parts of Rhizoma dioscoreae (parched)s, 18 parts of Radix Angelicae Sinensis, 54 parts of Radix Paeoniae Alba (parched)s, 36 parts in Colla Corii Asini, 36 parts of Chinese toon root white skins.