CN103071003B - Traditional Chinese medicine for promoting blood circulation, removing blood stasis and clearing and activating channels and collaterals - Google Patents
Traditional Chinese medicine for promoting blood circulation, removing blood stasis and clearing and activating channels and collaterals Download PDFInfo
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- CN103071003B CN103071003B CN 201310045350 CN201310045350A CN103071003B CN 103071003 B CN103071003 B CN 103071003B CN 201310045350 CN201310045350 CN 201310045350 CN 201310045350 A CN201310045350 A CN 201310045350A CN 103071003 B CN103071003 B CN 103071003B
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Abstract
The invention discloses a traditional Chinese medicine for promoting blood circulation, removing blood stasis and clearing and activating channels and collaterals. A prescription principle of principal, subordinate, adjuvant, and guide is taken; monkshood and radix aconiti agrestis are taken as principal drugs and are used for dispelling wind and eliminating dampness, penetrating channels and collaterals, and eliminating cold to stop pain; bile arisaema, frankincense and myrrh are taken as subordinate drugs and are used for expelling wind, relieving convulsion and relieving swelling and pain;root of common peony, red flower, ligusticum wallichii, radix achyranthis bidentatae, eucommia ulmoides and cassia twig are taken as adjuvant drugs and are used for removing heat to cool blood, invigorating the circulation of blood, promoting the circulation of qi, stimulating the menstrual flow and dispersing stagnate; and lumbricus is taken as guide drug and is used for adding the effects of clearing heat, eliminating wind, dredging collaterals and stopping pain and numbness. Through decocting with water and washout, the traditional Chinese medicine is capable of promoting blood circulation, removing blood stasis and clearing and activating channels and collaterals, so as to recover the muscle function and promote blood circulation and nerve conduction; the traditional Chinese medicine is an effective prescription for treating limb numbness caused by various reasons; the treating method belongs to a physical therapeutic method; and the method for treating an internal illness by external treatment by applying the traditional Chinese medicine and a modern pharmaceutical transdermal absorption theory are applied, so that the cutaneous absorption is quick, the bioavailability is high and no toxic side effect exists.
Description
Technical field
The present invention relates to the Chinese medicine of a kind of blood circulation promoting and blood stasis dispelling, dredge the meridian passage, is a kind of outer cleaning composition of Chinese herbal medicine, relates to the washout herbal composite that a variety of causes such as treating cerebrovascular sequelae, diabetic complication, rheumatism and rheumatoid disease causes numb hand and foot.Belong to technical field of Chinese medicines.
Background technology
Numb hand and foot is the disease with the symptom name, the phase class is in the various diseases of doctor trained in Western medicine: malnutrition disease (such as avitaminosis), metabolism and dyshormonia disease (such as diabetes, hypothyroidism etc.) and other diseases (such as infection, tumor), connective tissue disease (such as rheumatism, rheumatoid disease), the polyneuritis that in lysis, occurs, and peripheral lesion; Some articular strain disease is such as complication of wrist, tennis elbow, cervical vertebra/lumbar disease etc., also often take numbness, distending pain as cardinal symptom; Hypertension, the cerebrovascular disease that hyperlipidemia, cerebral arteriosclerosis cause, also often with numbness as main symptom or accompanied symptoms.
World Health Organization's statistics in 2010, world numbness of hands and feet patient gets over 200,000,000, and the increase of annual 10% speed, and wherein 30% numb patient is untimely because treating, finally paralysis or amputation.This disease main manifestations is brothers or numb limbs and tense tendons, can be with pain, and powerlessness, the extremity skin feel goes down or disappears.The lighter refers to that (toe) end is numb, and severe one may extend to whole palm and foot, extremity, even whole body.That patient's stolidity is stranded is swollen, joint stuffiness, motion are dumb, and conscious skin thickening is the same, insensitive etc.Above symptom frequentation is toward catching cold tired postemphasis.Primary disease is chronic progression, can continue the several years to ten more than year.
Motherland's medical science thinks that a numb card belongs to the pathological changes of QI and blood, and the complexity of common vital QI being weakened and pathogen being violent, simulataneous insufficiency and excessive changes clinically.How losing fortune because of the deficiency of vital energy, blood deficiency is not flourish, due to wind-damp numbness, expectorant stasis blocking stagnate.A numb card, take deficiency of qi and blood as this, wind-cold damp pathogen and expectorant, the stasis of blood is mark.Though the numb cause of disease has multiterminal, and its pathogenesis is all QI and blood and can not normally moves circulation so that the skin and flesh passages through which vital energy circulates lose support due to.Therefore, insufficiency of vital energy and blood, cold retardance, blood vessels are obstructed, QI and blood can not moisten that to support meridians are basic causes of disease of numb disease.
Doctor trained in Western medicine thinks that at present primary disease still belongs to difficult disease, lacks certainly curative effect, and comparatively speaking, effect is bad, and side effect is more.This external washout with traditional Chinese herbs therapy belongs to pure green physiotherapy, use method and the modern pharmacy Transdermal absorption of Chinese medicine inner disease outer treat theoretical, bioavailability is high, skin absorbs fast, the extremity blood flow that can increase sharply improves blood supply and supports, and helps nutrition and repair impaired limbs neural, have no side effect, enriched the modern treatment of numb treatment.
Summary of the invention
The object of the invention is to provide the Chinese medicine of a kind of blood circulation promoting and blood stasis dispelling, dredge the meridian passage, solves the deficiency that prior art exists, and the Chinese medicine of abundant treatment numb hand and foot.The percentage by weight of this ingredients composition is: Radix Aconiti, Radix Aconiti Kusnezoffii each 15 ~ 20%, Arisaema Cum Bile, Olibanum, Myrrha each 10 ~ 15%, Radix Paeoniae Rubra, Flos Carthami, Rhizoma Chuanxiong, Radix Achyranthis Bidentatae, the Cortex Eucommiae, Ramulus Cinnamomi each 5 ~ 10%, Pheretima 2 ~ 5%;
Radix Aconiti, Radix Aconiti Kusnezoffii: acrid in the mouth, warm in nature.Return liver, spleen, lung three warps.Expelling wind and removing dampness is arranged, cold expelling detumescence, the merit of antalgic.Can control anemofrigid-damp arthralgia, paralysis due to windstroke, tetanus, wind syndrome of head, coldness and pain in the epigastrium, carbuncle, furuncle etc." property of medicine opinion " record: black beak, its gas is sharp, the meridian dredging, sharp joint is sought footpath and is reached the footpath and direct reach disease institute.Modern pharmacological research, Radix Aconiti Kusnezoffii and Radix Aconiti effect are basic identical, and wherein contained alkaloid mainly suppresses motor nerve ending, and it has stronger analgesic activity.
Arisaema Cum Bile: bitter in the mouth is cold, little suffering, and is cool in nature.Return lung, liver, spleen channel.Have expelling wind and relieving convulsion, the merit of mass dissipating and swelling eliminating, dispelling wind and relieving convulsion.Give birth to and use external treatment carbuncle, snake bite and insect sting etc.Modern pharmacological research, Arisaema Cum Bile have calmness and analgesic activity, can obviously prolong the pentobarbital sodium length of one's sleep of mice; And hot plate method in mice shown that obvious analgesic activity is arranged.
Olibanum: property is hot, bitter, warm in nature.GUIXIN, liver, spleen channel.Have invigorate blood circulation, the merit of circulation of qi promoting, pain relieving.Can treat rheumatic arthralgia, traumatic injury, pharmacological research shows that this product has more significant analgesic activity. and multiple antibiotics is arranged, and strong bacteriostasis is arranged, can effectively kill infusorian etc.
Myrrha: bitter in the mouth, suffering, property is flat.Enter liver, spleen, the heart, kidney channel.Loose blood blood stasis removing is arranged, the merit of subduing swelling and relieving pain.Control traumatic injury, incised wound, muscles and bones, ulcer sore pain etc.Modern pharmacological research, contained eugenol in it has in various degree inhibitory action to multiple pathogenic dermatophytes.
Radix Paeoniae Rubra: bitter in the mouth, cold nature.Return Liver Channel.Function with clearing away heat and cooling blood, dissipating blood stasis for subsidence of swelling pain relieving.External cures mainly injury from falling down, carbuncle etc.Multiplex in the fever of the body of the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, carbuncle sore tumefacting virus.Modern pharmacological research, it has remarkable inhibitory action to blood clotting, and anti-thrombosis function is arranged, and thrombus formation time is obviously prolonged.The mechanism of Radix Paeoniae Rubra anticoagulant may with disturb hematoblastic energy metabolism, suppress the biosynthesis of TXA2 and improve in the platelet cAMP content etc. relevant.
Flos Carthami: acrid in the mouth, warm in nature.GUIXIN, Liver Channel.Promoting blood circulation to restore menstrual flow is arranged, the eliminating stasis to stop pain effect.Pharmaceutically safflower oil is widely used as the stabilizing agent of antioxidant and vitamin A, D.Applicable various varicosis, peripheral neuritis, blood circulation is bad, the diseases such as lower limb numbness.Modern pharmacological research, contained Carthamus yellow PARA FORMALDEHYDE PRILLS(91,95) foot swelling has obvious inhibitory action; The penetrating amount increase of the rat skin blood capillary that histamine is caused has obvious inhibitory action; Therefore, this medical instrument has obvious antiinflammatory action.
Rhizoma Chuanxiong: acrid in the mouth, warm in nature.Return liver, gallbladder, pericardium channel.Blood-activating and qi-promoting wind-expelling pain-stopping effect is arranged.Modern study is found, but this product anticoagulant and antithrombotic function.It alleviates thrombosis contraction in length, the dried wet weight of thrombosis; The ligustrazine that includes can significantly increase renal blood flow, alleviates Renal tissues damage, accelerates its repair process.
Radix Achyranthis Bidentatae: bitter in the mouth, sweet, sour, property is flat.Return liver, kidney channel.Invigorating the liver and kidney is arranged; Bone and muscle strengthening; Promoting blood circulation to restore menstrual flow, expelling wind and activating blood circulation; Blood stasis dispelling stimulates the menstrual flow; (blood) the descending merit of igniting.Cure mainly soreness of waist and knee joint; Flaccidity and weakness of the lower limbs; Traumatic injury; Carbuncle malignant boil etc." Bencao Jingshu " record: Radix Achyranthis Bidentatae, main cold-damp flaccidity syndrome and arthralgia syndrome, spasm of the limbs, gonalgia unable to flex and stretch the extremities person, the liver spleen is suffered from a deficiency of the kidney, then the heresy visitor of cold-damp form numbness, reach sick spasm of the limbs, the gonalgia unable to flex and stretch the extremities.This property of medicine is walked and descending, and it can be by cold-damp and eliminating impediment also must.Top capping liver then muscle is relaxed, the descending knee joint of then managing, and promoting the circulation of blood then pain ends.Modern pharmacological research, the contained ecdysterone of Radix Achyranthis Bidentatae has stronger protein synthesis facilitation, and anti-inflammatory and analgesic effect is arranged.
The Cortex Eucommiae: the little suffering of sweet in the mouth, warm in nature.Return liver, kidney channel.Many effects such as tool invigorating the liver and kidney, bone and muscle strengthening, blood pressure lowering.Shennong's Herbal is classified as top grade.Call it and " cure mainly waist and knee, invigorating middle warmer, beneficial vital essence, hard muscles and bones." both at home and abroad the expert Cortex Eucommiae composition has been carried out repeatedly careful research, Cortex Eucommiae free amino acid is few, a small amount of protein that contains, be with most foodstuffs like adequate proteins, namely can be hydrolyzed 8 seed amino acids that detect needed by human.15 kinds of contained mineral elements of the Cortex Eucommiae have been measured, the trace element such as zinc, copper, ferrum are wherein arranged, reach the macroelements such as calcium, phosphorus, potassium, magnesium, the 26S Proteasome Structure and Function of itself and human endocrine system, immunologic function system, growth promoter system has substantial connection, but such as the reparation of zinc acceleration of wound, ulcer, surgical wound etc., lymphocyte is played the short fissional effect of specificity.
Ramulus Cinnamomi: acrid in the mouth, sweet, warm in nature.GUIXIN, lung, urinary bladder channel.Promoting the flow of QI-blood by warming the meridian is arranged, expelling cold and relieving exterior syndrome; The effect of activating YANG and prormoting functioning of QI.Main arthralgia due to cold-dampnes; Extreme cold of the limbs etc.Modern pharmacological research, this medicine has weak analgesic activity, but the Ramulus Cinnamomi alcohol extract can suppress escherichia coli, bacillus subtilis and staphylococcus aureus external, to Staphylococcus albus, congratulate dysentery bacterium, Typhoid and paratyphoid first bacillus, streptococcus pneumoniae, aerobacteria, Bacillus proteus, anthrax bacillus, Salmonella enteritidis, vibrio cholera etc. inhibitory action (flat board dig a hole method) is also arranged. the Ramulus Cinnamomi decoct also has stronger inhibitory action to the Common Pathogenic dermatophytes.
Pheretima: acrid in the mouth, hardship, warm in nature.Return liver, spleen, heart channel.Li Shizhen (1518-1593 A.D.) is referred to as to have dredge the meridian passage in Compendium of Material Medica, the effect of blood circulation promoting and blood stasis dispelling, treatment Fengshi Guanjie pain, hemiplegia, Fengshi Guanjie pain, the diseases such as hemiplegia.External is coated with the diseases such as erysipelas, dermatitis rhus.Modern pharmacological research, this medicine has thrombolytic and anticoagulation, and the Pheretima decoct promotes Cryodesiccant Human Fibrinogen's cohesion that obvious antithrombase effect is arranged external to thrombin of beef.The external of Pheretima extracting solution is effective to local scleroderma, has the collagenase of specificity degrade collagen fiber through the biochemical analysis extract, and its curative effect is likely due to the local denatured collagen fiber degradation.
The side separates: this outer lotion is with take Radix Aconiti, Radix Aconiti Kusnezoffii as monarch drug, and expelling wind and removing dampness reaches meridians, dispersing cold for relieving pain thoroughly; Take Arisaema Cum Bile, Olibanum, Myrrha as minister, expelling wind and relieving convulsion reducing swelling and alleviating pain; Assistant is with Radix Paeoniae Rubra, Flos Carthami, Rhizoma Chuanxiong, Radix Achyranthis Bidentatae, the Cortex Eucommiae, Ramulus Cinnamomi, clearing away heat and cooling blood, and blood-activating and qi-promoting, dissipating blood stasis stimulates the menstrual flow; Pheretima is for making, to increase clearing heat for calming endogenous wind, the effect of collateral dredging stopping numbness pain.This herb mixture is by treating both the principal and the secondary aspects of a disease at the same time, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, and deficiency and excess is also transferred, but blood circulation promoting and blood stasis dispelling, dredge the meridian passage is uncomfortable with the treatment numb hand and foot.
The therapeutic mechanism of Chinese medicine of the present invention
External washout with traditional Chinese herbs, its effective ingredient directly arrive disease institute by acting on skin, and the pipe choking of dredging limbs peripheral blood increases blood flow, improves and supports, the performance curative effect.Its effect than after for oral administration by internal metabolism reach disease the effect that risen much bigger, behind the absorbing transmission from skin, very fast performance drug effect, enter blood circulation, Absorption And Metabolism in body, nutrition and impaired nerve and the blood vessel of reparation, toxin excretes, and side effect is little, is the advantage of external-use lotion.
The drug percutaneous skin penetrates into blood circulation two approach usually: 1) enter dermal tissue via horny layer and epidermal area, then absorbed by blood capillary, thereby enter blood circulation, usually also claim " epidermis approach ", this approach is the main path that medicine skin absorbs.In this approach, medicine can pass corneocyte itself and arrive active epidermis cell, but mainly is to arrive active epidermis via the corneocyte gap.Because the corneocyte gap is the lipid bilayer that is formed by various lipoid molecules, wherein exists hydrophilic district and hydrophobicity district.Nonpolar drug molecule is generally by way of hydrophobic region, and the polar medicine molecule mainly is to permeate by the hydrophilic district.2) by the accessory organ's tissue by skins such as sebaceous gland, sweat gland and hair follicles, generally also claim " appendages approach ", medicine is obviously faster than epidermis approach by the infiltration rate of skin " appendages ", but, its shared area only has about 0.1%, therefore, the effect of " appendages " approach is left in the basket in many instances.Yet water-soluble macromolecule medicine and ionic drug often are difficult to by being rich in the horny layer of lipoid, thereby " appendages " approach occupies critical role, namely become the percutaneous main path of ionic drug.
The drug application medicine at first arrives skin surface after discharging from preparation, the ingredient of dissolving is friction speed by its character and enters horny layer, and reaches the interface of active epidermis with diffusion way.Wherein, have some drugs to enter the active epidermis district of aqueous, some drugs enters hydrophobic epidermis district, continues diffusion and arrives corium, arrives at the human capillary vessel, enters at last blood circulation, plays a role.
The successful for the treatment of by Chinese herbs numb hand and foot of the present invention, bioavailability height, side effect is little.
The specific embodiment
Below in conjunction with the specific embodiment, the present invention will be further described.
Take by weighing Radix Aconiti 30g, Radix Aconiti Kusnezoffii 30g, Arisaema Cum Bile 20g, Olibanum 20g, Myrrha 15g, Radix Paeoniae Rubra 10g, Flos Carthami 10g, Rhizoma Chuanxiong 10g, Radix Achyranthis Bidentatae 10g, Cortex Eucommiae 10g, Ramulus Cinnamomi 10g, Pheretima 5g.Using method: by measuring above-mentioned Chinese medicine, add suitable quantity of water, soak after 30 minutes, then about 60 minutes of slow fire boiling is placed the affected part first the medicinal liquid top and is fumigated, and treats that medicinal liquid is cooled to preference temperature (do not scald and be advisable), soaks 30 minutes the affected part again.Every day 1 time, 10 days is a course for the treatment of.After the washout, dry skin, wind sheltering is cold.
Taboo: Chinese medicine composition is had the allergy sufferers forbidding.
Points for attention: anemia of pregnant woman's forbidding, idol has anaphylaxis.
Clinical data
For verifying its curative effect, show clinical data observation of curative effect report the test is as follows:
70 routine patients are I Out-patient Department and inpatient, male 40 examples wherein, women 30 examples; 25～67 years old age, average 43.72 years old; The course of disease 5 days～10 years.Be divided at random external washout with traditional Chinese herbs group (treatment group) by consultation time, oral vitamin B1, B12 organize (matched group).Treatment group male's 23 examples, women's 17 examples; Matched group male 18 examples, women's 12 examples; Clinical manifestation is simple hand anesthesia 17 examples, numb 24 examples of foot, numb 39 examples of hand anesthesia companion foot.Two groups at aspects such as sex, age, the state of an illness and the courses of disease without significant difference (P〉0.05), have comparability.
Therapeutic Method
Treatment group: give external washout with traditional Chinese herbs of the present invention, Chinese medicine is added suitable quantity of water, soak after 30 minutes, then about 60 minutes of slow fire boiling is placed the medicinal liquid top to the affected part first and is fumigated, and treats that medicinal liquid is cooled to preference temperature (do not scald and be advisable), soaks 30 minutes the affected part again.Every day 1 time, 10 days is a course for the treatment of, treats altogether 3 courses for the treatment of.After the washout, dry skin, wind sheltering is cold.
Matched group: oral vitamin B1 and methylcobalamin tablet, vitamin B1, each 10mg, every day 3 times, methylcobalamin tablet, each 0.5mg, every day 3 times, curative effect is 30 days.
More than two groups equal 10 days be a course for the treatment of, continued next course for the treatment of after three days at the interval, adds up curative effect after three courses for the treatment of.
Statistics curative effect after treatment finishes, parallel χ
2Check, P＜0.05 is for there being statistical significance.
Criterion of therapeutical effect
Cure: numb hand and foot disappears, and limb activity is convenient;
Produce effects; Numb hand and foot obviously alleviates, and slight paraesthesia is arranged, and does not affect walking and movable;
Effectively: numb hand and foot doing well,improving, paraesthesia are still more obvious, impact walking and movable;
Invalid: numb hand and foot is without improvement.
Therapeutic outcome
Table 1 liang group patient curative effect is (n=70) relatively
| Group | The example number | Cure | Produce effects | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 40 | 22 | 9 | 6 | 3 | 92.50 |
| Matched group | 30 | 9 | 6 | 7 | 8 | 73.33 |
By as seen from Table 1, two groups of effective percentage relatively, observation group obviously is better than matched group (χ
2=5.14, P＜0.05), difference has significant.
Clinical and experimental study proves that external washout with traditional Chinese herbs of the present invention has obvious therapeutic action to the symptom of numb hand and foot, can effectively improve symptom, and is reliable for effect, has no side effect, and is worthy to be popularized.
Claims (1)
1. a Chinese medicine preparation for the treatment of numb hand and foot is characterized in that: made by following crude drug: Radix Aconiti 30g, Radix Aconiti Kusnezoffii 30g, Arisaema Cum Bile 20g, Olibanum 20g, Myrrha 15g, Radix Paeoniae Rubra 10g, Flos Carthami 10g, Rhizoma Chuanxiong 10g, Radix Achyranthis Bidentatae 10g, Cortex Eucommiae 10g, Ramulus Cinnamomi 10g, Pheretima 5g; Preparation method is: by measuring above-mentioned Chinese medicine, add water, soaked slow fire boiling 60 minutes 30 minutes.
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| CN104491641A (en) * | 2014-12-29 | 2015-04-08 | 西安石油大学 | Fuming and washing medicine for promoting healing of pulled muscles |
| CN105456933A (en) * | 2015-12-23 | 2016-04-06 | 青岛友诚高新技术有限公司 | Traditional Chinese medicine capable of activating blood to remove stasis and clearing and activating channels and collaterals and preparation method of traditional Chinese medicine |
| CN106138637B (en) * | 2016-08-22 | 2020-01-07 | 陕西盘龙药业集团股份有限公司 | Traditional Chinese medicine composition for promoting blood circulation, removing blood stasis, resisting rheumatism and relieving pain and preparation method thereof |
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| CN1895642A (en) * | 2005-07-12 | 2007-01-17 | 侯保君 | Traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain and preparation method thereof |
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| CN1895642A (en) * | 2005-07-12 | 2007-01-17 | 侯保君 | Traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain and preparation method thereof |
Non-Patent Citations (2)
| Title |
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| 严婉英等.治痹十法.《河北中医》.1998,第20卷(第01期), |
| 治痹十法;严婉英等;《河北中医》;19980115;第20卷(第01期);30-31 * |
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