CN103054029A - 按年龄配制的婴儿营养*** - Google Patents
按年龄配制的婴儿营养*** Download PDFInfo
- Publication number
- CN103054029A CN103054029A CN2013100228070A CN201310022807A CN103054029A CN 103054029 A CN103054029 A CN 103054029A CN 2013100228070 A CN2013100228070 A CN 2013100228070A CN 201310022807 A CN201310022807 A CN 201310022807A CN 103054029 A CN103054029 A CN 103054029A
- Authority
- CN
- China
- Prior art keywords
- infant formula
- formula
- lactalbumin
- infant
- protein content
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 235000016709 nutrition Nutrition 0.000 title claims abstract description 9
- 230000035764 nutrition Effects 0.000 title claims abstract description 8
- 235000013350 formula milk Nutrition 0.000 claims abstract description 111
- 235000018102 proteins Nutrition 0.000 claims abstract description 27
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 27
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 27
- 102000004407 Lactalbumin Human genes 0.000 claims description 53
- 108090000942 Lactalbumin Proteins 0.000 claims description 53
- 235000013305 food Nutrition 0.000 claims description 42
- 239000002775 capsule Substances 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 20
- 238000002360 preparation method Methods 0.000 claims description 20
- 235000020243 first infant milk formula Nutrition 0.000 claims description 15
- 230000001228 trophic effect Effects 0.000 claims description 10
- 102000010445 Lactoferrin Human genes 0.000 claims description 5
- 108010063045 Lactoferrin Proteins 0.000 claims description 5
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 claims description 5
- 235000021242 lactoferrin Nutrition 0.000 claims description 5
- 229940078795 lactoferrin Drugs 0.000 claims description 5
- 239000006041 probiotic Substances 0.000 claims description 3
- 235000018291 probiotics Nutrition 0.000 claims description 3
- 102000007544 Whey Proteins Human genes 0.000 abstract description 14
- 108010046377 Whey Proteins Proteins 0.000 abstract description 14
- 239000005862 Whey Substances 0.000 abstract description 12
- 102000011632 Caseins Human genes 0.000 abstract description 5
- 108010076119 Caseins Proteins 0.000 abstract description 5
- 239000005018 casein Substances 0.000 abstract description 4
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 abstract description 4
- 235000021240 caseins Nutrition 0.000 abstract description 4
- 230000007423 decrease Effects 0.000 abstract 2
- 239000000203 mixture Substances 0.000 description 29
- WQZGKKKJIJFFOK-FPRJBGLDSA-N beta-D-galactose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-FPRJBGLDSA-N 0.000 description 25
- 150000001875 compounds Chemical class 0.000 description 17
- 150000001720 carbohydrates Chemical class 0.000 description 10
- 235000014633 carbohydrates Nutrition 0.000 description 10
- 150000002632 lipids Chemical class 0.000 description 10
- 102000004190 Enzymes Human genes 0.000 description 9
- 108090000790 Enzymes Proteins 0.000 description 9
- 229940088598 enzyme Drugs 0.000 description 9
- 235000021255 galacto-oligosaccharides Nutrition 0.000 description 9
- 150000003271 galactooligosaccharides Chemical class 0.000 description 9
- 235000009508 confectionery Nutrition 0.000 description 8
- 229910052500 inorganic mineral Inorganic materials 0.000 description 8
- 239000011707 mineral Substances 0.000 description 8
- 229930003231 vitamin Natural products 0.000 description 8
- 235000013343 vitamin Nutrition 0.000 description 8
- 239000011782 vitamin Substances 0.000 description 8
- 229940088594 vitamin Drugs 0.000 description 8
- 150000003722 vitamin derivatives Chemical class 0.000 description 8
- 238000006640 acetylation reaction Methods 0.000 description 7
- 230000007062 hydrolysis Effects 0.000 description 6
- 238000006460 hydrolysis reaction Methods 0.000 description 6
- 244000005700 microbiome Species 0.000 description 6
- 239000000758 substrate Substances 0.000 description 6
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 5
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 5
- 239000004472 Lysine Substances 0.000 description 5
- 235000020256 human milk Nutrition 0.000 description 5
- 210000004251 human milk Anatomy 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 235000013406 prebiotics Nutrition 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 235000019197 fats Nutrition 0.000 description 4
- 239000008101 lactose Substances 0.000 description 4
- 229920001542 oligosaccharide Polymers 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 241000186604 Lactobacillus reuteri Species 0.000 description 3
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 3
- 239000004473 Threonine Substances 0.000 description 3
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 description 3
- 210000000481 breast Anatomy 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000000855 fermentation Methods 0.000 description 3
- 230000004151 fermentation Effects 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 235000021125 infant nutrition Nutrition 0.000 description 3
- 229940001882 lactobacillus reuteri Drugs 0.000 description 3
- 230000000813 microbial effect Effects 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 150000002482 oligosaccharides Chemical class 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 241000901050 Bifidobacterium animalis subsp. lactis Species 0.000 description 2
- 241001608472 Bifidobacterium longum Species 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 2
- 241000186605 Lactobacillus paracasei Species 0.000 description 2
- 241000218588 Lactobacillus rhamnosus Species 0.000 description 2
- OVRNDRQMDRJTHS-BKJPEWSUSA-N N-acetyl-D-hexosamine Chemical compound CC(=O)NC1C(O)O[C@H](CO)C(O)C1O OVRNDRQMDRJTHS-BKJPEWSUSA-N 0.000 description 2
- SQVRNKJHWKZAKO-LUWBGTNYSA-N N-acetylneuraminic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)CC(O)(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-LUWBGTNYSA-N 0.000 description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
- 239000005642 Oleic acid Substances 0.000 description 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 2
- 102000004357 Transferases Human genes 0.000 description 2
- 108090000992 Transferases Proteins 0.000 description 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 2
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 2
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 229940009289 bifidobacterium lactis Drugs 0.000 description 2
- 229940009291 bifidobacterium longum Drugs 0.000 description 2
- 235000020247 cow milk Nutrition 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 230000003301 hydrolyzing effect Effects 0.000 description 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 2
- 230000006651 lactation Effects 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- LWGJTAZLEJHCPA-UHFFFAOYSA-N n-(2-chloroethyl)-n-nitrosomorpholine-4-carboxamide Chemical compound ClCCN(N=O)C(=O)N1CCOCC1 LWGJTAZLEJHCPA-UHFFFAOYSA-N 0.000 description 2
- 229940060155 neuac Drugs 0.000 description 2
- CERZMXAJYMMUDR-UHFFFAOYSA-N neuraminic acid Natural products NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO CERZMXAJYMMUDR-UHFFFAOYSA-N 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 2
- 235000021119 whey protein Nutrition 0.000 description 2
- SECPZKHBENQXJG-FPLPWBNLSA-N (Z)-Palmitoleic acid Natural products CCCCCC\C=C/CCCCCCCC(O)=O SECPZKHBENQXJG-FPLPWBNLSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 102000030902 Galactosyltransferase Human genes 0.000 description 1
- 108060003306 Galactosyltransferase Proteins 0.000 description 1
- 102000051366 Glycosyltransferases Human genes 0.000 description 1
- 108700023372 Glycosyltransferases Proteins 0.000 description 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
- 102000002268 Hexosaminidases Human genes 0.000 description 1
- 108010000540 Hexosaminidases Proteins 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 description 1
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 1
- 102000008192 Lactoglobulins Human genes 0.000 description 1
- 108010060630 Lactoglobulins Proteins 0.000 description 1
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 239000005913 Maltodextrin Substances 0.000 description 1
- 229920002774 Maltodextrin Polymers 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000009793 Milk Hypersensitivity Diseases 0.000 description 1
- 102000014171 Milk Proteins Human genes 0.000 description 1
- 108010011756 Milk Proteins Proteins 0.000 description 1
- 201000010859 Milk allergy Diseases 0.000 description 1
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- 235000021319 Palmitoleic acid Nutrition 0.000 description 1
- 108010019160 Pancreatin Proteins 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 235000019485 Safflower oil Nutrition 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 108010073771 Soybean Proteins Proteins 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 238000010793 Steam injection (oil industry) Methods 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 235000019486 Sunflower oil Nutrition 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 229930003448 Vitamin K Natural products 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- MNCUCCJMXIWMJJ-OWOJBTEDSA-N [(e)-2-thiocyanatoethenyl] thiocyanate Chemical compound N#CS\C=C\SC#N MNCUCCJMXIWMJJ-OWOJBTEDSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- IXWNIYCPCRHGAE-DFZOHVKFSA-N alpha-D-GalNAc-(1->3)-D-Gal Chemical compound CC(=O)N[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@H]1[C@@H](O)[C@@H](CO)OC(O)[C@@H]1O IXWNIYCPCRHGAE-DFZOHVKFSA-N 0.000 description 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 229940114079 arachidonic acid Drugs 0.000 description 1
- 235000021342 arachidonic acid Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 229940071604 biogaia Drugs 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229960005069 calcium Drugs 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 235000013351 cheese Nutrition 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 239000011651 chromium Substances 0.000 description 1
- SECPZKHBENQXJG-UHFFFAOYSA-N cis-palmitoleic acid Natural products CCCCCCC=CCCCCCCCC(O)=O SECPZKHBENQXJG-UHFFFAOYSA-N 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 235000004626 essential fatty acids Nutrition 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000021323 fish oil Nutrition 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 150000008272 galactosaminides Chemical class 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 230000007366 host health Effects 0.000 description 1
- 239000000413 hydrolysate Substances 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- JCQLYHFGKNRPGE-FCVZTGTOSA-N lactulose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 JCQLYHFGKNRPGE-FCVZTGTOSA-N 0.000 description 1
- 229960000511 lactulose Drugs 0.000 description 1
- PFCRQPBOOFTZGQ-UHFFFAOYSA-N lactulose keto form Natural products OCC(=O)C(O)C(C(O)CO)OC1OC(CO)C(O)C(O)C1O PFCRQPBOOFTZGQ-UHFFFAOYSA-N 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 235000020778 linoleic acid Nutrition 0.000 description 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 1
- 229960004488 linolenic acid Drugs 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 229940035034 maltodextrin Drugs 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
- 239000011733 molybdenum Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 239000002777 nucleoside Substances 0.000 description 1
- 125000003835 nucleoside group Chemical group 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 229940055695 pancreatin Drugs 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000007065 protein hydrolysis Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 235000019710 soybean protein Nutrition 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/30—Dietetic or nutritional methods, e.g. for losing weight
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/16—Agglomerating or granulating milk powder; Making instant milk powder; Products obtained thereby
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/19—Dairy proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pediatric Medicine (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Dairy Products (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
本发明涉及按年龄配制的婴儿营养***。具体而言，本发明涉及包含乳清蛋白和酪蛋白的蛋白源用于向婴儿提供按年龄配制的营养***的用途，其中所述的***包含2种婴儿配方食品，每一种适合于不同年龄的婴儿并且每一种包含蛋白源，其中每一种配方食品的乳清蛋白和酪蛋白的比例在100:0至40:60的范围内选择并且根据婴儿年龄而降低，每一种配方食品的蛋白含量在1.5-3.0g蛋白/100千卡的范围内选择并且根据婴儿年龄而降低。
Description
本申请为2008年11月26日提交的、发明名称为“按年龄配制的婴儿营养***”的PCT申请PCT/EP2008/066202的分案申请，所述PCT申请进入中国国家阶段的日期为2010年5月25日，申请号为200880117695.4。
技术领域
本发明涉及按年龄配制的婴儿营养***。
背景技术
对人乳的组分的研究已经进行了多年并且至今仍未完成。然而，已知人乳的组成随着哺乳期进程而发生可见的变化。例如，如
等人在Am J Clin Nutr1976;29:1127-33中所述，在整个哺乳期期间人乳的蛋白含量降低，同时乳糖含量升高。
对所有婴儿都推荐母乳喂养。然而，在某些情况下，母乳喂养由于医学上的原因而出现不足或不成功，或者母亲选择不进行母乳喂养。针对这些情况已经开发出了婴儿配方食品。常规的婴儿配方食品分为2类，早期配方食品，用于从出生到4-6个月龄的婴儿，其为该年龄组提供完全营养；和所谓的后期配方食品，用于4-6个月龄到12个月龄的婴儿，其在断奶进程的过程中与逐渐加量的其他食物例如婴儿谷类和水果泥(puréed fruits)、蔬菜和其他食物一起组合来喂养婴儿。许多可从商业上购买到的婴儿配方食品是基于牛乳蛋白并且含有乳清蛋白和/或酪蛋白，但其他可购买到的婴儿配方食品是基于大豆蛋白。当同时存在乳清蛋白和酪蛋白时，两者之间的比例可以在90:10和10:90之间变化。
通常，婴儿配方食品的蛋白含量在1.8和3.5g/100千卡之间，早期配方食品的蛋白含量趋向于该范围的下限，后期配方食品的蛋白含量趋向于该范围的上限。例如，Nestlé
早期婴儿配方食品的蛋白含量是1.83g/100千卡和Nestlé
后期婴儿配方食品的蛋白含量是3.1g/100千卡。
为了在生命的最初几个月内不完全进行母乳喂养的婴儿的利益，需要继续开发在其营养特性方面尽可能复制人乳的婴儿配方食品。
发明内容
本发明提供了包含乳清蛋白和酪蛋白的蛋白源用于向婴儿提供按年龄配制的营养***的用途，其中所述的***包含两种婴儿配方食品，每一种适合于不同年龄的婴儿，并且每一种包含蛋白源，其中每一种配方食品的乳清蛋白和酪蛋白的比例在100:0至40:60的范围内选择并且根据婴儿年龄而降低，每一种配方食品的蛋白含量在1.5-3.0g蛋白/100千卡的范围内选择并且根据婴儿年龄而降低。
本发明涵盖了用于从出生至2个月的婴儿的按年龄配制的营养***，该***包含第一婴儿配方食品和第二婴儿配方食品，第一婴儿配方食品具有包含乳清蛋白和任选的酪蛋白的蛋白源、并且具有在100:0和60:40之间的乳清蛋白和酪蛋白的比例以及2.0-3.0g蛋白/100千卡的蛋白含量，第二婴儿配方食品具有包含乳清蛋白和酪蛋白的蛋白源、并且具有在70:30和50:50之间的乳清蛋白和酪蛋白的比例以及1.8-2.0g蛋白/100千卡的蛋白含量，条件是第二配方食品的蛋白含量或乳清蛋白和酪蛋白的比例的任意一者或两者低于第一配方食品。
本发明还涵盖了向在生命的最初6个月内的婴儿提供营养的方法，该方法包含在生命的最初1至8周的至少部分的时间内给婴儿喂第一婴儿配方食品和在生命的最初6个月的剩余时间的至少部分时间内给婴儿喂第二婴儿配方食品，第一婴儿配方食品具有包含乳清蛋白和任选的酪蛋白的蛋白源、并且具有在100:0和60:40之间的乳清蛋白和酪蛋白的比例和2.0-3.0g蛋白/100千卡的蛋白含量，第二婴儿配方食品具有包含乳清蛋白和酪蛋白的蛋白源、并且具有在70:30和50:50之间的乳清蛋白和酪蛋白的比例和1.7-2.1g蛋白/100千卡的蛋白含量，条件是第二配方食品的蛋白含量或乳清蛋白和酪蛋白的比例的任意一者或两者低于第一配方食品。
在本说明书中，下列术语具有以下的含义：
“婴儿”是指12个月龄以下的儿童；
“婴儿配方食品”是指针对在生命最初6个月内的婴儿的完全营养的食品。
除非另有说明，否则全部百分数均以重量计。
本发明提供包含乳清蛋白和酪蛋白的蛋白源用于向婴儿提供按年龄配制的营养***的用途。该***包含至少2种婴儿配方食品，每一种配方食品具有根据婴儿年龄在100:0至40:60、优选70:30至50:50的范围内选择的乳清蛋白和酪蛋白的比例，以及根据婴儿年龄在1.5-3.0g蛋白/100千卡、优选1.8-2.5g蛋白/100千卡的范围内选择的蛋白含量。乳清蛋白和酪蛋白的比例和蛋白含量都随着婴儿年龄的增加而降低。因此，本发明的按年龄配制的营养***可以包含例如用于在生命的前2周内的婴儿的第一婴儿配方食品，其乳清蛋白和酪蛋白的比例为70:30和蛋白含量为2.5g蛋白/100千卡；用于在生命的接下来的6周内的婴儿的第二婴儿配方食品，其乳清蛋白和酪蛋白的比例为60:40和蛋白含量为2.0g蛋白/100千卡；和用于在生命的第3至第6个月内的婴儿的第三婴儿配方食品，其乳清蛋白和酪蛋白的比例为60:40和蛋白含量为1.8g蛋白/100千卡。
这种按年龄配制的营养***可以另外包含具有50:50的乳清蛋白和酪蛋白的比例和1.8g蛋白/100千卡的蛋白含量的第四婴儿配方食品。该配方食品适合于在生命的第二个6个月内的婴儿。
用于本发明的婴儿配方食品也可以添加生物活性的乳清蛋白质，即乳铁蛋白。已知乳铁蛋白尤其促进新生儿胃肠道的生长和发育成熟。优选地，用于本发明的婴儿配方食品的乳铁蛋白含量也随着婴儿年龄的增加而降低，并且充当以评价配方食品的蛋白含量为目的的蛋白质的一部分，和充当以计算配方食品的乳清蛋白和酪蛋白的比例为目的的乳清蛋白质的一部分。用于本发明的婴儿配方食品的乳铁蛋白含量优选为0.1-1.5克/升、更优选0.3-1.0克/升。
用于本发明的按年龄配制的营养***的婴儿配方食品可以进一步包含碳水化合物源和脂质源。配方食品的碳水化合物含量和脂质含量的任意一者也可以作为婴儿年龄的函数而变化，优选碳水化合物含量和脂质含量二者都这样变化。通常来说，并且至少对于从出生到6个月龄的婴儿来说，碳水化合物含量可以随着婴儿年龄的增加而升高，例如9.0-12.0g碳水化合物/100千卡、优选10.1-11.6g碳水化合物/100千卡，并且脂质含量可以随着婴儿年龄的增加而降低，例如6.0-4.5g脂质/100千卡、优选5.6-5.1g脂质/100千卡。
蛋白质的类型被认为对本发明并不重要，条件是应当满足必需氨基酸含量的最低要求并且满足对乳清蛋白和酪蛋白的比例和蛋白含量的要求。因此，可以使用基于乳清蛋白、酪蛋白及其混合物的蛋白源。关于乳清蛋白，可以使用酸乳清或甜乳清或其混合物，并且希望以任何比例的α-乳白蛋白和β-乳球蛋白。
乳清蛋白可以是改良的甜乳清。甜乳清可以容易地从制作奶酪的副产品得到，并且经常用于制备基于牛乳的婴儿配方食品。然而，甜乳清包括被称为酪蛋白-糖-巨肽(CGMP)的成分，该成分不合需要地富含苏氨酸并且缺乏色氨酸。从甜乳清中除去CGMP，得到苏氨酸含量更接近人乳的苏氨酸含量的蛋白质。该改良的甜乳清可以添加那些含量较低的氨基酸(主要是组氨酸和色氨酸)。从甜乳清中除去CGMP的方法记载于EP880902中，
并且基于该改良的甜乳清的婴儿配方食品记载于WO01/11990中。
蛋白质可以是完整的或水解的或者完整的和水解的蛋白质的混合物。可以希望它提供部分水解的蛋白质(水解度在2到20%之间)，例如用于认为有发生牛乳过敏风险的婴儿。如果需要水解的蛋白质，水解过程可以按需要和如本领域中已知的进行。例如，通过如EP322589中所述的分两步进行酶水解乳清部分，可以制备乳清蛋白水解产物。对于被广泛水解的蛋白质，使用Alcalase2.4L(EC940459)、然后使用Neutrase0.5L(可从NovoNordisk Ferment AG获得)、然后在55℃使用胰酶，可以使乳清蛋白经历三重水解。如果用作原料的乳清部分基本上不含乳糖，则蛋白质在水解过程中经历少得多的赖氨酸阻断。这使得赖氨酸阻断的程度从按赖氨酸总重计为约15%降到按赖氨酸总重计小于约10%；例如按赖氨酸总重计约7%，这极大地改善了蛋白源的营养质量。
用于本发明的婴儿配方食品可以含有碳水化合物源。可以使用任何常规用于婴儿配方食品中的碳水化合物源，例如乳糖、蔗糖、麦芽糖糊精、淀粉及其混合物，但优选的碳水化合物源是乳糖。
用于本发明的婴儿配方食品可以含有脂质源。该脂质源可以是任何适用于婴儿配方食品的脂质或脂肪。优选的脂肪源包括乳脂、棕榈油酸甘油酯、高油酸的葵花油和高油酸的红花油。也可以加入必需脂肪酸亚油酸和α-亚麻酸，例如加入少量的含有大量有效的花生四烯酸和二十二碳六烯酸的油，例如鱼油或微生物油类。脂质源优选具有约5:1至约15:1、例如约8:1至约10:1的n-6与n-3脂肪酸的比例。
用于本发明的婴儿配方食品也可以含有全部被认为是每日饮食中所必需的并且是营养上显著量的维生素和矿物质。已经对某些维生素和矿物质确立了最低要求。任选地存在于婴儿配方食品中的矿物质、维生素和其他营养素的实例包括维生素A、维生素B1、维生素B2、维生素B6、维生素B12、维生素E、维生素K、维生素C、维生素D、叶酸、肌醇、烟酸、生物素、泛酸、胆碱、钙、磷、碘、铁、镁、铜、锌、锰、氯化物、钾、钠、硒、铬、钼、牛磺酸和L-肉碱。矿物质通常以盐的形式加入。特定的矿物质和其他的维生素的存在和量根据目标婴儿群体而变化。
婴儿配方食品也可以包含至少一种益生菌菌株。益生菌是对宿主的健康或幸福有益的微生物细胞制剂或微生物细胞组分。合适的益生菌菌株包括鼠李糖乳酸杆菌(Lactobacillus rhamnosus)ATCC53103(可从芬兰的Valio Oy获得，商标为LGG)、鼠李糖乳杆菌CGMCC1.3724、类干酪乳杆菌(Lactobacillus paracasei)CNCM I-2116、罗伊氏乳杆菌(Lactobacillusreuteri)ATCC55730和罗伊氏乳杆菌DSM17938(可从BioGaia AB获得)、乳双歧杆菌(Bifidobacterium lactis)CNCM I-3446(尤其是由丹麦ChristianHansen公司出售，商标为Bb12)和长双歧杆菌(Bifidobacterium longum)ATCC BAA-999(由日本的Morinaga Milk Industry有限公司出售，商标为BB536)。如果存在益生菌，其量同样优选作为婴儿年龄的函数而变化。通常来说，益生菌含量可以随着婴儿年龄的增加而升高，例如10e3-10e12cfu/g配方食品、更优选10e4-10e8cfu/g配方食品(干重)。
婴儿配方食品也可以含有至少一种益生元，其量为0.3-10%。益生元是不可消化的食物成分，其通过选择性地刺激一种或有限数目的细菌在结肠内的生长和/或活性来有益地影响宿主，从而改善宿主健康。该成分是不可消化的，其含义是指该成分在胃或小肠内不被分解和吸收，从而完整地到达结肠，并在此被有益的细菌选择性地发酵。益生元的实例包括某些低聚糖，例如低聚果糖(FOS)和低聚半乳糖(GOS)。可以使用益生元的组合，例如90%GOS和10%短链低聚果糖(例如以
为商标销售的产品)，或90%GOS和10%菊糖(例如以
为商标销售的产品)。
特别优选的益生元是低聚半乳糖、N-乙酰化低聚糖和唾液酸化的低聚糖的混合物，其中，N-乙酰化低聚糖占低聚糖混合物的0.5-4.0%，低聚半乳糖占低聚糖混合物的92.0-98.5%，唾液酸化的低聚糖占低聚糖混合物的1.0-4.0%。该混合物在下文中称为“CMOS-GOS”。优选地，用于本发明的组合物含有按干物质重量计为2.5-15.0重量%的CMOS-GOS，条件是组合物包含至少0.02重量%的N-乙酰化低聚糖、至少2.0重量%的低聚半乳糖和至少0.04重量%的唾液酸化的低聚糖。
合适的N-乙酰化低聚糖包括GalNAcα1,3Galβ1,4Glc和Galβ1,6GalNAcα1,3Galβ1,4Glc。通过氨基葡糖苷酶和/或氨基半乳糖苷酶对N-乙酰-葡萄糖和/或N-乙酰-半乳糖的作用可以制备N-乙酰化低聚糖。同样地，出于该目的，可以使用N-乙酰-半乳糖转移酶和/或N-乙酰-葡糖转移酶。也可以通过使用相应的酶(重组的或天然的)的发酵工艺和/或微生物发酵来制备N-乙酰化低聚糖。在后一种情况中，微生物可以表达其天然的酶和底物或者可以被改造成产生相应的底物和酶。可以使用单一的微生物培养物或混合的培养物。可以用起始于任何聚合度(DP)(从DP=1起)的受体底物来形成N-乙酰化低聚糖。如在Wrodnigg,T.M.;Stutz,A.E.(1999)Angew.Chem.Int.Ed.38:827-828中所述，另一种选择是游离的或者连接在低聚糖(例如乳果糖)上的酮-己糖(例如果糖)化学转化为N-乙酰己糖胺或含有低聚糖的N-乙酰己糖胺。
合适的低聚半乳糖包括Galβ1,6Gal、Galβ1,6Galβ1,4Glc、Galβ1,6Galβ1,6Glc、Galβ1,3Galβ1,3Glc、Galβ1,3Galβ1,4Glc、Galβ1,6Galβ1,6Galβ1,4Glc、Galβ1,6Galβ1,3Galβ1,4Glc、Galβ1,3Galβ1,6Galβ1,4Glc、Galβ1,3Galβ1,3Galβ1,4Glc、Galβ1,4Galβ1,4Glc和Galβ1,4Galβ1,4Galβ1,4Glc。合成的低聚半乳糖，例如Galβ1,6Galβ1,4Glc、Galβ1,6Galβ1,6Glc、Galβ1,3Galβ1,4Glc、Galβ1,6Galβ1,6Galβ1,4Glc、Galβ1,6Galβ1,3Galβ1,4Glc和Galβ1,3Galβ1,6Galβ1,4Glc、Galβ1,4Galβ1,4Glc和Galβ1,4Galβ1,4Galβ1,4Glc及其混合物，可以以商标
和
购买得到。其他的低聚糖供应商是Dextra Laboratories、Sigma-AldrichChemie GmbH和Kyowa Hakko Kogyo有限公司。或者，可以用特定的糖基转移酶(例如半乳糖转移酶)来制备中性的低聚糖。
合适的唾液酸化的低聚糖包括NeuAcα2,3Galβ1,4Glc和NeuAcα2,6Galβ1,4Glc。通过色谱或过滤技术可以从天然来源(例如动物乳)中分离出这些唾液酸化的低聚糖。或者，它们也可以通过使用特异性的唾液酸基转移酶的生物技术(通过基于发酵工艺的酶(重组的或天然的酶)或者通过微生物发酵工艺)来进行生产。在后一种情况中，微生物可以表达其天然的酶和底物或者可以被改造成产生相应的底物和酶。可以使用单一的微生物培养物或混合的培养物。通过从任何聚合度(DP)开始(从DP=1起)的受体底物可以形成唾液酸-寡糖。
婴儿配方食品可以任选地含有其他可能具有有益效果的物质，例如核苷酸、核苷等。
可以用任何合适的方法制备用于本发明的婴儿配方食品。例如，通过将蛋白源、碳水化合物源和脂肪源以适当的比例混合到一起，可以制备婴儿配方食品。如果使用，乳化剂可以包含在混合物之中。此时可以加入维生素和矿物质，但通常稍后才加入以防止热降解。在混合之前，可以将任何亲脂性的维生素、乳化剂等溶解于脂肪源中。然后可以混入水(优选经历了反渗透的水)，从而形成液体混合物。
随后，液体混合物可以进行热处理以降低细菌量。例如，液体混合物可以快速加热至约80℃至约110℃的温度持续约5秒至约5分钟。这可以通过蒸汽喷射或通过热交换器(例如板式换热器)来进行。
然后，液体混合物可以冷却至约60℃至约85℃；例如通过快速冷却。然后可以使液体混合物匀化；例如分2个阶段，第一阶段约7MPa至约40MPa，第二阶段约2MPa至约40MPa。然后可以进一步冷却匀化的混合物，以加入任何热敏感的组分，例如维生素和矿物质。此时，将匀化的混合物的pH和固体含量方便地进行标准化。
将匀化的混合物转移至合适的干燥装置中，例如喷雾干燥器或冷冻干燥器，并且转化为粉末。粉末应当具有低于约5重量%的含水量。
如果想要加入益生菌，可以按照任何合适的方法对其进行培养和制备，从而通过例如冷冻干燥或喷雾干燥加入到婴儿配方食品中。或者，可以从专业的供应商(例如Christian Hansen和Morinaga)处购买到用于加入食品(例如婴儿配方食品)中的已制成适宜形式的细菌制品。通过干法混合，可以将细菌制品加入到粉末状的婴儿配方食品中。
本发明涵盖了用于从出生至2个月的婴儿的按年龄配制的营养***，该***包含第一婴儿配方食品和第二婴儿配方食品，第一婴儿配方食品具有包含乳清蛋白和任选的酪蛋白的蛋白源、并且具有在100:0和60:40之间的乳清蛋白和酪蛋白的比例和2.0-3.0g蛋白/100千卡的蛋白含量，第二婴儿配方食品具有包含乳清蛋白和酪蛋白的蛋白源、并且具有在70:30和50:50之间的乳清蛋白和酪蛋白的比例和1.8-2.0g蛋白/100千卡的蛋白含量。
本发明涵盖了向在生命的最初6个月内的婴儿提供营养的方法，该方法包含在生命的最初1至8周的至少部分的时间内给婴儿喂第一婴儿配方食品和在生命的最初6个月的剩余时间的至少部分时间内给婴儿喂第二婴儿配方食品，第一婴儿配方食品具有包含乳清蛋白和任选的酪蛋白的蛋白源、并且具有在100:0和60:40之间的乳清蛋白和酪蛋白的比例和2.0-3.0g蛋白/100千卡的蛋白含量，第二婴儿配方食品具有包含乳清蛋白和酪蛋白的蛋白源、并且具有在70:30和50:50之间的乳清蛋白和酪蛋白的比例和1.7-2.1g蛋白/100千卡的蛋白含量，条件是第二配方食品的蛋白含量或乳清蛋白和酪蛋白的比例的任意一者或两者低于第一配方食品。
优选地，本发明的方法包含在生命的约最初2至4周内给婴儿喂第一婴儿配方食品，然后再给婴儿喂第二婴儿配方食品，第一婴儿配方食品具有在80:20和60:40之间的乳清蛋白和酪蛋白的比例和2.0-3.0g蛋白/100千卡的蛋白含量，第二婴儿配方食品具有在70:30和50:50之间的乳清蛋白和酪蛋白的比例和1.8-2.0g蛋白/100千卡的蛋白含量。甚至更优选地，对2-4周到约2个月龄喂第二婴儿配方食品和在婴儿生命的最初6个月的剩余时间内喂第三婴儿配方食品，第三婴儿配方食品具有在70:30和50:50之间的乳清蛋白和酪蛋白的比例和1.8-2.0g蛋白/100千卡的蛋白含量，其中第三配方食品的蛋白含量或乳清蛋白和酪蛋白的比例的任意一者或两者低于第二配方食品。
本发明的按年龄配制的营养***特别适合用于采用一次性胶囊来制备单次服用的婴儿配方的方法中，每个一次性胶囊含有单位剂量的浓缩形式的配方食品并且配有包含在胶囊中的开口装置，从而允许重构的配方食品直接从胶囊流入接收容器(例如奶瓶)中。该方法记载于WO2006/077259中。可以将不同的配方食品包装到各个胶囊中并且以多个包装的形式(其含有足够数量的胶囊以满足例如婴儿一周的需要)提供给消费者。合适的胶囊构造在WO2003/059778中公开。
胶囊可以含有粉末形式或浓缩液形式的婴儿配方食品，在这两种情况下，都可用适量的水进行重构。胶囊中的婴儿配方食品的组成和量都可以按照婴儿的年龄而变化。如果需要，可以提供不同大小的胶囊，用来制备用于不同年龄的婴儿的婴儿配方食品。
应当理解，提供胶囊或其他的单元(例如棒状包装或小药囊)，使父母或其他的看护者有机会使婴儿的喂养方案更加接近于“黄金标准”，即，按照需要进行母乳喂养的婴儿，其中每个胶囊或其他的单元含有接近适合特定年龄的婴儿需求而制备单次服用的婴儿配方食品所需要的足量的婴儿配方食品。换句话说，相对而言，因为与制备婴儿配方食品的常规方法相比，制备该食品的一餐更快并且更加方便，而且因为该食品更适合于相关年龄的婴儿的需要，所以父母或其他的看护者可发现更容易根据婴儿所需来喂养婴儿。尽管通常认为直到约6个月大的婴儿需要每4个小时喂一次，但是在不同的婴儿之间、甚至在同一婴儿的最初6个月内不同发育阶段之间的需求实际上有很大的差异。
以下仅通过举例说明的方式给出本发明的按年龄配制的营养***的实例。如本领域技术人员所理解的，除了以下具体描述的成分，所举例的婴儿配方食品也可含有这类产品中常见的其它成分，特别是包括维生素和矿物质。
具体实施方式
实施例1
实施例2
Claims (10)
1.向婴儿提供营养的方法，该方法包含：
-在生命的最初2至4周的时间内给所述婴儿喂第一婴儿配方食品，第一婴儿配方食品具有在80:20和60:40之间的乳清蛋白和酪蛋白的比例的蛋白源和2.0-3.0g蛋白/100千卡的蛋白含量，接着
-给所述婴儿喂第二婴儿配方食品，第二婴儿配方食品具有在70:30和50:50之间的乳清蛋白和酪蛋白的比例和1.8-2.0g蛋白/100千卡的蛋白含量，
-条件是第二配方食品的蛋白含量或乳清蛋白和酪蛋白的比例的任意一者或两者低于第一配方食品。
2.根据权利要求1的方法，其中所述第二婴儿配方食品在2-4周到约2个月龄喂给婴儿，并且其中第三婴儿配方食品具有在70:30和50:50之间的乳清蛋白和酪蛋白的比例和1.8-2.0g蛋白/100千卡的蛋白含量，并且其中第三配方食品的蛋白含量或乳清蛋白和酪蛋白的比例的任意一者或两者低于第二配方食品，并且其中在婴儿生命的最初6个月的剩余时间内喂第三婴儿配方食品。
3.根据权利要求2的方法，其包含第四婴儿配方食品，第四婴儿配方食品具有50:50的乳清蛋白和酪蛋白的比例和1.8g蛋白/100千卡的蛋白含量，其中所述第四婴儿配方食品在生命的第二个6个月期间喂给婴儿。
4.根据权利要求1-3中任意一项的方法，其还包括：
-采用一次性胶囊来制备单次服用的婴儿配方食品，每个一次性胶囊含有单位剂量的浓缩形式的配方食品并且配有包含在胶囊中的开口装置，从而允许重构的配方食品直接从胶囊流入接收容器例如婴儿奶瓶中。
5.用于婴儿的按年龄配制的营养***，该***包含：
-用于在生命的最初2至4周的时间内的第一婴儿配方食品，第一婴儿配方食品具有在80:20和60:40之间的乳清蛋白和酪蛋白的比例的蛋白源和2.0-3.0g蛋白/100千卡的蛋白含量，和
-第二婴儿配方食品，其具有在70:30和50:50之间的乳清蛋白和酪蛋白的比例和1.8-2.0g蛋白/100千卡的蛋白含量，
-条件是第二配方食品的蛋白含量或乳清蛋白和酪蛋白的比例的任意一者或两者低于第一配方食品。
6.根据权利要求5的***，其中所述第一和/或第二婴儿配方食品包含益生菌菌株。
7.根据权利要求5或6的***，其中所述第一和/或第二婴儿配方食品包含乳铁蛋白。
8.根据权利要求5-7中任意一项的***，其中所述的婴儿配方食品装在一次性胶囊中，每个一次性胶囊含有单位剂量的浓缩形式的配方食品并且配有包含在胶囊中的开口装置，从而允许重构的配方食品直接从胶囊流入接收容器例如婴儿奶瓶中。
9.根据权利要求5-8中任意一项的***，其包含具有在70:30和50:50之间的乳清蛋白和酪蛋白的比例和1.8-2.0g蛋白/100千卡的蛋白含量的第三婴儿配方食品，并且其中第三配方食品的蛋白含量或乳清蛋白和酪蛋白的比例的任意一者或两者低于第二配方食品，并且其中在婴儿生命的最初6个月的剩余时间内喂第三婴儿配方食品。
10.根据权利要求9的***，其包含第四婴儿配方食品，第四婴儿配方食品具有50:50的乳清蛋白和酪蛋白的比例和1.8g蛋白/100千卡的蛋白含量。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07121541 | 2007-11-26 | ||
| EP07121541.2 | 2007-11-26 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200880117695.4A Division CN101873806B (zh) | 2007-11-26 | 2008-11-26 | 按年龄配制的婴儿营养*** |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103054029A true CN103054029A (zh) | 2013-04-24 |
| CN103054029B CN103054029B (zh) | 2015-06-24 |
Family
ID=39616454
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200880117695.4A Active CN101873806B (zh) | 2007-11-26 | 2008-11-26 | 按年龄配制的婴儿营养*** |
| CN201310016987.1A Active CN103039793B (zh) | 2007-11-26 | 2008-11-26 | 按年龄配制的婴儿营养*** |
| CN201310017499.2A Active CN103005453B (zh) | 2007-11-26 | 2008-11-26 | 按年龄配制的婴儿营养*** |
| CN201310022807.0A Active CN103054029B (zh) | 2007-11-26 | 2008-11-26 | 按年龄配制的婴儿营养*** |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200880117695.4A Active CN101873806B (zh) | 2007-11-26 | 2008-11-26 | 按年龄配制的婴儿营养*** |
| CN201310016987.1A Active CN103039793B (zh) | 2007-11-26 | 2008-11-26 | 按年龄配制的婴儿营养*** |
| CN201310017499.2A Active CN103005453B (zh) | 2007-11-26 | 2008-11-26 | 按年龄配制的婴儿营养*** |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US20110195144A1 (zh) |
| EP (5) | EP2224826B1 (zh) |
| JP (1) | JP2011504365A (zh) |
| KR (1) | KR20100103468A (zh) |
| CN (4) | CN101873806B (zh) |
| AU (1) | AU2008328864B2 (zh) |
| BR (1) | BRPI0819445A2 (zh) |
| CA (1) | CA2706636A1 (zh) |
| ES (3) | ES2681215T3 (zh) |
| MX (2) | MX2010005586A (zh) |
| MY (1) | MY160434A (zh) |
| RU (1) | RU2463810C2 (zh) |
| UA (1) | UA103180C2 (zh) |
| WO (1) | WO2009068549A1 (zh) |
| ZA (1) | ZA201004529B (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108135190A (zh) * | 2015-09-28 | 2018-06-08 | 雀巢产品技术援助有限公司 | 性别特异性合成营养组合物以及包含这类组合物的营养体系产品 |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8498729B2 (en) | 2008-08-29 | 2013-07-30 | Smp Logic Systems Llc | Manufacturing execution system for use in manufacturing baby formula |
| EP2452574A1 (en) * | 2010-11-15 | 2012-05-16 | Nestec S.A. | Age-tailored nutritional formula with particularly adapted caloric density for young infants |
| CN107646976A (zh) * | 2009-10-28 | 2018-02-02 | 维利奥有限公司 | 乳清蛋白产品及其制备方法 |
| MX348895B (es) * | 2009-10-29 | 2017-07-03 | Nestec Sa | Composiciones nutricionales que comprenden lactoferrina y probióticos y kits de partes de los mismos. |
| EP2404507A1 (en) | 2010-07-08 | 2012-01-11 | Nestec S.A. | Array of age-tailored nutritional formula with optimum fat content |
| EP2452571A1 (en) | 2010-11-15 | 2012-05-16 | Nestec S.A. | Array of complementary infant/young child nutritional compositions |
| EP2452573A1 (en) * | 2010-11-15 | 2012-05-16 | Nestec S.A. | Age-tailored nutritional composition with animal fats and vegetable fats |
| EP2452575A1 (en) | 2010-11-15 | 2012-05-16 | Nestec S.A. | Array of age-tailored nutritional formula with probiotics |
| EP2452572A1 (en) | 2010-11-15 | 2012-05-16 | Nestec S.A. | Age-tailored nutritional formula with particularly adapted caloric density for infants and children |
| US20120135103A1 (en) * | 2010-11-30 | 2012-05-31 | Mead Johnson Nutrition Company | Staged Infant Feeding Regimen To Promote Healthy Development And Growth |
| CN103327828B (zh) * | 2010-12-29 | 2016-05-11 | Mjn美国控股有限责任公司 | 使用营养组合物抑制病原体的方法 |
| US8648036B2 (en) | 2010-12-29 | 2014-02-11 | Mead Johnson Nutrition Company | Use of nutritional compositions including lactoferrin and one or more prebiotics in inhibiting adhesion of pathogens in the gastrointestinal tract |
| US8968722B2 (en) | 2010-12-29 | 2015-03-03 | Mead Johnson Nutrition Company | Milk-based nutritional compositions containing lactoferrin and uses thereof |
| EP2658389A1 (en) * | 2010-12-29 | 2013-11-06 | MJN U.S. Holdings LLC | Use of nutritional compositions including lactoferrin in supporting resistance to diseases and conditions |
| US20120171328A1 (en) * | 2011-01-05 | 2012-07-05 | Dattatreya Banavara | Composition comprising heat labile milk proteins and process for preparing same |
| FI124323B (fi) | 2011-02-18 | 2014-06-30 | Valio Oy | Maitopohjainen tuote ja menetelmä sen valmistamiseksi |
| EP2514435A1 (en) * | 2011-04-19 | 2012-10-24 | Nestec S.A. | Infant formula for use in the prevention of cardiovascular diseases |
| JP2014516589A (ja) | 2011-06-20 | 2014-07-17 | エイチ．ジェイ．ハインツ カンパニー | プロバイオティック組成物及び方法（ｐｒｏｂｉｏｔｉｃｃｏｍｐｏｓｉｔｉｏｎａｎｄｍｅｔｈｏｄｓ） |
| MX2011007872A (es) * | 2011-07-26 | 2013-01-29 | Nucitec Sa De Cv | Composicion nutrimental para niños que presentan reflujo, colico y/o estreñimiento. |
| US20140271562A1 (en) * | 2011-10-18 | 2014-09-18 | Nestec S.A. | Composition for use in brain growth and/or cognitive and/or psychomotor development |
| AU2012351604A1 (en) * | 2011-12-14 | 2014-06-19 | Nestec S.A. | Methods for predicting age-or developmental stage-appropriate foods for children |
| EP2797431A1 (en) * | 2011-12-27 | 2014-11-05 | Abbott Laboratories | Reduced calorie infant formulas containing specific whey to casein ratios |
| MX2012010487A (es) * | 2012-09-11 | 2014-03-26 | Nucitec Sa De Cv | Composicion de nutrimientos y sustancias bioactivas que favorecen el crecimiento y que disminuyen la intolerancia y los efectos adversos en infantes prematuros. |
| AU2013316685B2 (en) * | 2012-09-12 | 2016-06-30 | Nestec S.A. | Thick textured acidified dairy or dairy-like products and methods for producing same |
| US20140087025A1 (en) * | 2012-09-12 | 2014-03-27 | Nestec S.A. | Thickened dairy or dairy-like products and methods for producing same |
| MX2015012205A (es) | 2013-03-13 | 2016-05-26 | Prolacta Bioscience Inc | Productos de leche humana altos en grasa. |
| WO2014195351A1 (en) * | 2013-06-07 | 2014-12-11 | Nestec S.A. | Method and system for determining replenishment information |
| CN106231924A (zh) * | 2013-11-29 | 2016-12-14 | 雀巢产品技术援助有限公司 | 按年龄定制的具有不同蛋白质含量的营养组合物 |
| ES2729757T3 (es) | 2013-11-29 | 2019-11-06 | Nestle Sa | Uso de composiciones nutritivas que tienen un reducido contenido de proteínas |
| WO2015085551A1 (en) * | 2013-12-12 | 2015-06-18 | Nestec S.A. | Array of age-tailored nutritional formulae with optimum mineral nutrient content |
| US20160316808A1 (en) * | 2013-12-12 | 2016-11-03 | Nestec S.A. | Synthetic nutritional compositions especially adapted for male and female infants and young children |
| US11357249B2 (en) | 2013-12-12 | 2022-06-14 | Societe Des Produits Nestle S.A. | Synthetic milk compositions comprising n-6 eicosatrienoic acid and polar lipids for infants younger and older than three months for healthy establishment of cognitive function |
| WO2015086176A1 (en) * | 2013-12-12 | 2015-06-18 | Nestec S.A. | Synthetic milk compositions for infants less than three months old and for infants and children more than three months for ensuring optimal growth and preventing obesity |
| WO2015085557A1 (en) * | 2013-12-12 | 2015-06-18 | Nestec S.A. | Array of age-tailored infant formula with optimum protein content and lactose content |
| US20160309768A1 (en) | 2013-12-12 | 2016-10-27 | Nestec S.A. | Synthetic milk compositions for optimal growth and development and prevention of obesity in male and female infant and children |
| WO2015085555A1 (en) * | 2013-12-12 | 2015-06-18 | Nestec S.A. | Array of age-tailored infant formula with optimum protein content and lactose content |
| MX2016007561A (es) * | 2013-12-12 | 2016-10-03 | Nestec Sa | Sistema de embalaje para composicion nutricional infantil con dispositivos de dosificacion. |
| WO2015085549A1 (en) * | 2013-12-12 | 2015-06-18 | Nestec S.A. | An age-tailored nutrition system for an infant |
| WO2015154262A1 (en) * | 2014-04-09 | 2015-10-15 | Nestle (China) Ltd. | Gender specific synthetic nutritional compositions and nutritional systems comprising them. |
| WO2015154263A1 (en) * | 2014-04-09 | 2015-10-15 | Nestle (China) Ltd. | Gender specific synthetic nutritional compositions and nutritional systems comprising them |
| WO2015154260A1 (en) * | 2014-04-09 | 2015-10-15 | Nestle (China) Ltd. | Gender specific synthetic nutritional compositions and nutritional systems comprising them. |
| WO2015154265A1 (en) | 2014-04-09 | 2015-10-15 | Nestle (China) Ltd. | Gender specific synthetic nutritional compositions and nutritional systems comprising them |
| ES2725464T3 (es) * | 2014-09-25 | 2019-09-24 | Nestle Sa | Sistema de fórmula infantil con niveles adaptativos de oligosacáridos de leche humana (OLH) |
| EP3240429A4 (en) * | 2014-12-30 | 2018-12-05 | Prolacta Bioscience, Inc. | Methods of preventing and treating bronchopulmonary dysplasia using high fat human milk products |
| RU2018110559A (ru) | 2015-08-27 | 2019-09-27 | Нестек С.А. | Искусственные питательные композиции, оптимизированные для младенцев определенных возрастов, и содержащие их системы питания |
| RU2018110560A (ru) * | 2015-08-27 | 2019-09-27 | Нестек С.А. | Дифференцированные по полу искусственные питательные композиции и содержащие их системы питания |
| RU2601623C1 (ru) * | 2015-09-02 | 2016-11-10 | Федеральное государственное бюджетное научное учреждение "Научный центр здоровья детей" (ФГБНУ НЦЗД) | Молочные смеси для вскармливания детей первого года жизни |
| AU2015410707A1 (en) * | 2015-09-28 | 2018-01-18 | Société des Produits Nestlé S.A. | Gender specific synthetic nutritional compositions and nutritional systems comprising them |
| EP3397064A4 (en) * | 2015-12-30 | 2019-10-30 | Prolacta Bioscience, Inc. | HUMAN MILK PRODUCTS USEFUL IN PRE- AND POST-OPERATIVE CARE |
| EP3706586A1 (en) | 2017-11-09 | 2020-09-16 | Société des Produits Nestlé S.A. | An array of age-tailored nutritional formula for infants and young children for use in the prevention of sub-optimal body composition |
| US11197917B2 (en) | 2017-12-01 | 2021-12-14 | ByHeart, Inc. | Formulations for nutritional support in subjects in need thereof |
| JP7338978B2 (ja) * | 2019-02-01 | 2023-09-05 | 雪印メグミルク株式会社 | 乳幼児用栄養組成物 |
| JP2021065164A (ja) * | 2019-10-24 | 2021-04-30 | 森永乳業株式会社 | 乳児用栄養組成物 |
| AU2022226958A1 (en) * | 2021-02-24 | 2023-09-14 | Milk Care Co., Inc. | Infant formulas containing human breast milk proteins |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993016601A1 (en) * | 1992-02-26 | 1993-09-02 | The Boots Company Plc | Infant feed |
| US20040228955A1 (en) * | 2002-01-16 | 2004-11-18 | Jean-Luc Denisart | Closed capsule with opening means |
| CN1829452A (zh) * | 2003-06-23 | 2006-09-06 | 雀巢技术公司 | 婴儿或较大婴儿配方代乳品 |
| CN1852665A (zh) * | 2003-09-18 | 2006-10-25 | 阿尔拉食品公司 | 婴儿配方乳品 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4977137B1 (en) * | 1987-06-03 | 1994-06-28 | Baylor College Medicine | Lactoferrin as a dietary ingredient promoting the growth of the gastrointestinal tract |
| ATE84680T1 (de) | 1987-12-23 | 1993-02-15 | Nestle Sa | Verfahren zur herstellung eines molkeeiweisshydrolysates und eines hypoallergenen nahrungsmittels. |
| US5405637A (en) * | 1993-06-30 | 1995-04-11 | Bristol-Myers Squibb Company | Milk protein partial hydrolysate and infant formula containing same |
| JPH07111860A (ja) * | 1993-10-20 | 1995-05-02 | Morinaga Milk Ind Co Ltd | ミネラル成分を調整した乳蛋白質組成物 |
| CN1129524A (zh) * | 1994-09-09 | 1996-08-28 | 哈尔滨松花江第二乳品厂 | 婴幼儿阶段奶粉 |
| DE19510765A1 (de) * | 1995-03-24 | 1996-09-26 | Alexander Buehlbaecker | Verfahren zur Herstellung von Frühgeborenen-, Säuglings- und Diätnahrung |
| JP3789146B2 (ja) * | 1995-03-27 | 2006-06-21 | 雪印乳業株式会社 | オリゴ糖含有栄養組成物 |
| CN1128103A (zh) * | 1995-07-31 | 1996-08-07 | 浙江乳鸽宝保健品总公司 | 含活性双歧杆菌奶粉及其制造方法 |
| US5635199A (en) * | 1995-10-27 | 1997-06-03 | Nestec Ltd. | Support of pediatric patients |
| JP2968751B2 (ja) * | 1997-04-10 | 1999-11-02 | 明治乳業株式会社 | 母乳類似脂質組成物配合育児用調製乳 |
| EP0880902A1 (fr) | 1997-05-27 | 1998-12-02 | Nestlé Produkte AG | Procédé de traitement d'une matiére première lactosérique |
| MXPA01010778A (es) * | 1999-04-29 | 2003-08-20 | Nestle Sa | Composicion para una formula para infantes, que tiene un bajo contenido de treonina. |
| GB9923048D0 (en) * | 1999-09-29 | 1999-12-01 | Nestle Sa | Composition comprising casein protein and whey protein |
| EP1062873A1 (en) * | 1999-12-13 | 2000-12-27 | N.V. Nutricia | Improved infant formula, protein hydrolysate for use in such an infant formula, and method for producing such a hydrolysate |
| JP2002306125A (ja) * | 2001-04-12 | 2002-10-22 | Morinaga Milk Ind Co Ltd | プロバイオティクスを含有する包装容器入り乳幼児用栄養組成物 |
| ES2324913T3 (es) * | 2003-02-10 | 2009-08-19 | University College London | Sistema de alimentacion para bebes. |
| RU2379975C2 (ru) * | 2003-09-18 | 2010-01-27 | Арла Фудс Амба | Добавка в состав для детского питания |
| CN101703360A (zh) * | 2005-01-24 | 2010-05-12 | 雀巢技术公司 | 营养组合物制备方法 |
| MX2007012697A (es) * | 2005-04-13 | 2008-01-14 | Nestec Sa | Formula para infantes con probioticos. |
| BRPI0618261A2 (pt) * | 2005-11-04 | 2011-08-23 | Arla Foods Amba | concentrado e composição derivados de um produto de leite enriquecido em sialil-lactose que ocorre naturalmente, processo para preparação dos mesmos e produto |
| US20070243290A1 (en) * | 2006-04-18 | 2007-10-18 | Melody Thompson | Method of tailoring infant formulas to individual nutritional needs prior to use |
-
2008
- 2008-11-26 WO PCT/EP2008/066202 patent/WO2009068549A1/en active Application Filing
- 2008-11-26 ES ES11193309.9T patent/ES2681215T3/es active Active
- 2008-11-26 RU RU2010126149/13A patent/RU2463810C2/ru active
- 2008-11-26 EP EP08854301.2A patent/EP2224826B1/en active Active
- 2008-11-26 CN CN200880117695.4A patent/CN101873806B/zh active Active
- 2008-11-26 AU AU2008328864A patent/AU2008328864B2/en active Active
- 2008-11-26 CN CN201310016987.1A patent/CN103039793B/zh active Active
- 2008-11-26 JP JP2010534501A patent/JP2011504365A/ja active Pending
- 2008-11-26 BR BRPI0819445A patent/BRPI0819445A2/pt not_active Application Discontinuation
- 2008-11-26 ES ES10187102T patent/ES2715312T3/es active Active
- 2008-11-26 EP EP10187102.8A patent/EP2272381B1/en active Active
- 2008-11-26 CN CN201310017499.2A patent/CN103005453B/zh active Active
- 2008-11-26 ES ES08854301T patent/ES2715300T3/es active Active
- 2008-11-26 EP EP11193309.9A patent/EP2433507B1/en active Active
- 2008-11-26 MX MX2010005586A patent/MX2010005586A/es active IP Right Grant
- 2008-11-26 EP EP11193307.3A patent/EP2433506A3/en not_active Withdrawn
- 2008-11-26 CN CN201310022807.0A patent/CN103054029B/zh active Active
- 2008-11-26 EP EP12163842.3A patent/EP2476322A3/en not_active Withdrawn
- 2008-11-26 MX MX2011011095A patent/MX348901B/es unknown
- 2008-11-26 KR KR1020107011392A patent/KR20100103468A/ko not_active Application Discontinuation
- 2008-11-26 UA UAA201007612A patent/UA103180C2/ru unknown
- 2008-11-26 CA CA2706636A patent/CA2706636A1/en not_active Abandoned
- 2008-11-26 MY MYPI2010002061A patent/MY160434A/en unknown
- 2008-11-26 US US12/743,963 patent/US20110195144A1/en not_active Abandoned
-
2010
- 2010-06-25 ZA ZA2010/04529A patent/ZA201004529B/en unknown
-
2013
- 2013-10-09 US US14/049,487 patent/US20140037788A1/en not_active Abandoned
- 2013-10-09 US US14/049,344 patent/US20140037787A1/en not_active Abandoned
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993016601A1 (en) * | 1992-02-26 | 1993-09-02 | The Boots Company Plc | Infant feed |
| US20040228955A1 (en) * | 2002-01-16 | 2004-11-18 | Jean-Luc Denisart | Closed capsule with opening means |
| CN1829452A (zh) * | 2003-06-23 | 2006-09-06 | 雀巢技术公司 | 婴儿或较大婴儿配方代乳品 |
| CN1852665A (zh) * | 2003-09-18 | 2006-10-25 | 阿尔拉食品公司 | 婴儿配方乳品 |
Non-Patent Citations (8)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108135190A (zh) * | 2015-09-28 | 2018-06-08 | 雀巢产品技术援助有限公司 | 性别特异性合成营养组合物以及包含这类组合物的营养体系产品 |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101873806B (zh) | 按年龄配制的婴儿营养*** | |
| CN106714583A (zh) | 具有自适应水平的人乳寡糖(hmo)的婴儿配方食品体系 | |
| AU2014361225B2 (en) | Array of age-tailored infant formula with optimum protein content and lactose content | |
| CN103209601A (zh) | 一组互补的婴儿/幼儿营养组合物 | |
| CN103209604A (zh) | 具有特别适于婴幼儿和儿童的热量密度的依年龄定制的营养配方产品 | |
| AU2014361225A1 (en) | Array of age-tailored infant formula with optimum protein content and lactose content | |
| AU2013406461A1 (en) | Liquid milk fortifier composition with relatively high lipid content | |
| TW201208582A (en) | Array of age-tailored nutritional formula with optimum fat content | |
| AU2014361231A1 (en) | An age-tailored nutrition system for an infant | |
| EP3079506A1 (en) | An age-tailored nutrition system for an infant | |
| CN103906435A (zh) | 用于促进镁吸收和/或镁保留的组合物 | |
| AU2014361227B2 (en) | Array of age-tailored infant formula with optimum protein content and lactose content | |
| AU2014361227A1 (en) | Array of age-tailored infant formula with optimum protein content and lactose content | |
| CN105979795A (zh) | 按年龄定制的、矿物质营养素含量最合适的营养配方食品系列产品 | |
| TW201304695A (zh) | 一系列依年齡特製之含有益生菌之營養配方 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20190724 Address after: Vevey Patentee after: SOCIETE DES PRODUITS NESTLE S. A. Address before: Vevey Patentee before: Nestle Products Technical Assistance Co., Ltd. |
|
| TR01 | Transfer of patent right |