CN103041128B - Bitter almond and perilla leaf pectoral syrup and preparation method thereof - Google Patents
Bitter almond and perilla leaf pectoral syrup and preparation method thereof Download PDFInfo
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- CN103041128B CN103041128B CN201310032323.4A CN201310032323A CN103041128B CN 103041128 B CN103041128 B CN 103041128B CN 201310032323 A CN201310032323 A CN 201310032323A CN 103041128 B CN103041128 B CN 103041128B
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Abstract
The invention discloses a bitter almond and perilla leaf pectoral syrup and a preparation method thereof. The bitter almond and perilla leaf pectoral syrup comprises the following raw materials: perilla leaves, radix platycodi, bitter almond, radix scutellariae, herba ephedra, fritillaria thunbergii, simple syrup, sodium benzoate, ethylparaben and distilled water. The preparation method comprises the following steps of: extracting volatile oil in the perilla leaves through a steam distilling method; mixing the perilla leaf dregs after the oil extraction with the radix platycodi, the bitter almond, the radix scutellariae, the herba ephedra and the fritillaria thunbergii; adding water for the detection; filtrating, and mixing the filtrate; standing and precipitating; taking supernatant; adding the simple syrup, the sodium benzoate and the ethylparaben, and uniformly mixing; boiling; adding the volatile oil; adding the distilled water to the specified amount, thereby obtaining the bitter almond and perilla leaf pectoral syrup. The bitter almond and perilla leaf pectoral syrup provided by the invention is accurate in materials, high in effective component content and remarkable in efficacy. The preparation method of the bitter almond and perilla leaf pectoral syrup can extract effective components in medicinal materials maximally.
Description
Technical field
The present invention relates to a kind of cough syrup, specifically a kind of almond perilla anti-cough syrup, the invention still further relates to the preparation method of almond perilla anti-cough syrup.
Technical background
Chronic bronchitis is the chronic nonspecific inflammation of trachea, bronchial mucosa and surrounding tissue thereof, is one of China's commonly encountered diseases and frequently-occurring disease.Modern medicine is not yet completely clear about the definite cause of disease of chronic bronchitis and pathogenesis.It is generally acknowledged, in the time that Abwehrkraft des Koepers goes down, exist on the basis of sensitivity in various degree at air flue, have one or more exopathogenic factors to exist, comprise the factors such as infection, physics and chemistry allergy, weather, smoking, prolonged and repeated effect can develop into chronic bronchitis.What environment in recent years was polluted increases the weight of and antibiotic abuse, and the more aobvious power single-action of the infection of doctor trained in Western medicine and symptomatic treatment measure is micro-.
At present, almond perilla anti-cough syrup on the market, complicated process of preparation, and can not fully extract the effective ingredient in medical material, curative effect is not very desirable.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of almond perilla anti-cough syrup, and the accurate and effective component content of these almond perilla anti-cough syrup materials is high, evident in efficacy.Another technical problem that the present invention will solve is to provide the preparation method of this almond perilla anti-cough syrup, requires the method can farthest extract the effective ingredient in medical material.
For solving the problems of the technologies described above, the invention provides a kind of almond perilla anti-cough syrup, its preparation method comprises the following steps:
(1) extraction of volatile oil: Folium Perillae 50 g are placed in boiling flask, the distilled water that adds 12～18 times of Folium Perillae weight, is connected to volatile oil extractor on boiling flask, adds water to overflowing in round-bottomed flask in the arm of volatile oil extractor, on connect spherical condensation tube, soak 1～3 h, then start vapor distillation, after 3～6 h, stop distillation, place 0.5～2 h, oil to volatile oil extractor is limpid, collects respectively volatile oil and carries the residue after oil, for subsequent use;
(2) water extraction: Radix Platycodonis 30 g, Semen Armeniacae Amarum 30 g, Radix Scutellariae 20 g, Herba Ephedrae 30 g, Bulbus Fritillariae Thunbergii 20 g are mixed with the residue that step (1) Folium Perillae is carried after oil, add the distilled water of 8～12 times of mixture total weight amounts, heating decocts 1～3 time, after each decoction 1～2 h, filter, merge filtrate, the filtrate after merging is staticly settled to rear absorption supernatant, obtain the first supernatant, again by the first supernatant concentrating under reduced pressure, staticly settle, again draw and obtain the second supernatant;
(3) mix: in the second supernatant, add simple syrup 60 mL, sodium benzoate 0.33 g, ethyl hydroxybenzoate 0.05 g, after mix homogeneously, boil, then the volatile oil that adds step (1) to collect, adding distil water to 100 mL, stirs evenly and obtains almond perilla anti-cough syrup.
Folium Perillae main component, containing volatile oil, includes perillaldehyde, left-handed limonene and a small amount of australene.Folium Perillae pharmacological action has calmness, analgesia, antipyretic, antitussive, emesis, anti-bacteria and anti-virus, antiinflammatory, anti-allergic effects, for anemofrigid cold, and cough vomiting and nausea etc.
Semen Armeniacae Amarum contains amygdaloside, fatty oil, emulsin, amygdalase, prunase, estrone, alpha-estradiol, desmosterol etc.Pharmacological action has relieving cough and asthma, loosening bowel to relieve constipation, anti-inflammatory and antalgic, antitumor action, cures mainly cough and asthma, dryness of the intestine constipation etc.Amygdaloside can be hydrolyzed by enteric microorganism enzyme or the contained emulsin of Semen Armeniacae Amarum itself in vivo, produces micro-hydrocyanic acid and benzaldehyde, respiratory center is had to inhibitory action, the object of reach antitussive, relievining asthma.
Radix Platycodonis nature and flavor hardship, pungent, flat, returns lung meridian, has lung qi dispersing, sore-throat relieving, eliminates the phlegm, effect of evacuation of pus, for diseases such as cough with copious phlegm, smooth, pharyngalgia uncomfortable in chest, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.Radix Platycodonis mainly contains Radix Platycodi total saponins, also contains the compositions such as polysaccharide, sterols and glucosides thereof, fatty oil, fatty acid.Pharmacological action has and has eliminating phlegm and relieving cough, anti-inflammatory and antalgic, immunomodulating etc.
Herba Ephedrae contains the compositions such as ephedrine, d-pseudo-ephedrine, volatile oil, 2，3，5，6-tetramethylpyrazine L-α-terpinenol.Pharmacological action has cough-relieving, eliminates the phlegm, relievings asthma, diaphoresis, diuresis, antiallergic action, antiinflammatory, antipyretic, resisting pathogenic microbes, stimulating central nervous system system etc.
Bulbs of Fritillaria thunbergii Miq is containing peimine, peiminine, Propeimine, in addition also have four kinds of alkaloids that content is few: the not fragrant alkali of Peimidine, shellfish, peimisine and Peimitidine, modern pharmacological research shows that Bulbus Fritillariae Thunbergii pharmacological action has relieving cough and resolving phlegm, heat clearing away eliminating stagnation, lax tracheal smooth muscle, antalgic and inflammation relieving, antibacterial etc.
Radix Scutellariae contains the compositions such as baicalin, wogonoside, wogonin, baicalin, neobaicalein-I, neobaicalein-II, Yang Huangsu, has heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive effect.
In preparation method of the present invention, with the volatile oil in extraction by steam distillation Folium Perillae, by the control to amount of water, soak time, extraction time, can reach and be close to 100% extraction volatile oil, both ensure making full use of of raw material, improved again the active constituent content of almond perilla anti-cough syrup.
In preparation method of the present invention, with things such as the amygdalosides in water extraction method extraction residue a few herbs and Folium Perillae residue, by to amount of water, extraction time, the control of each extraction time, can farthest extract the active substance in Chinese medicinal material, further improve the content of almond perilla anti-cough syrup effective ingredient, and then improved the curative effect of almond perilla anti-cough syrup.
It is high that almond perilla anti-cough syrup provided by the invention has the accurate and effective component content of medication, and the feature that toxic and side effects is little has good curative effect to chronic bronchitis, is a kind of medicine of desirable treatment chronic bronchitis.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described.
In the present embodiment, the concrete consumption proportion of almond perilla anti-cough syrup each primary raw material used is: Folium Perillae 50 g, Radix Platycodonis 30 g, Semen Armeniacae Amarum 30 g, Radix Scutellariae 20 g, Herba Ephedrae 30 g, Bulbus Fritillariae Thunbergii 20 g, simple syrup 60 mL, sodium benzoate 0.33 g, ethyl hydroxybenzoate 0.05 g.
The preparation method of the almond perilla anti-cough syrup of the present embodiment comprises the following steps:
(1) extraction of volatile oil: take 50 g Folium Perillaes and be placed in boiling flask, the distilled water that adds 12～18 times of Folium Perillae weight, is connected to volatile oil extractor on boiling flask, adds water to overflowing in round-bottomed flask in the arm of volatile oil extractor, on connect spherical condensation tube, soak 1～3 h, start vapor distillation, after 3～6 h, stop distillation, place 0.5～2 h, oil to volatile oil extractor is limpid, collects respectively volatile oil and carries the residue after oil, for subsequent use;
(2) water extraction: take Semen Armeniacae Amarum 30 g, Radix Platycodonis 30 g, Herba Ephedrae 30 g, Bulbus Fritillariae Thunbergii 20 g, Radix Scutellariae 20 g, the residue of carrying after oil with step (1) Folium Perillae mixes, add the distilled water of 8～12 times of mixture total weight amounts, heating decocts 1～3 time, after each decocting time 1～2 h, filters, and merges filtrate, filtrate after merging staticly settles rear absorption supernatant, obtain the first supernatant, then by the first supernatant concentrating under reduced pressure, staticly settle, again draw and obtain the second supernatant;
(3) mix: in the second supernatant, add simple syrup 60mL, sodium benzoate 0.33 g, ethyl hydroxybenzoate 0.05 g, after mix homogeneously, boil, then the volatile oil that adds step (1) to collect, adding distil water to 100 mL, stirs evenly and obtains almond perilla anti-cough syrup.
In suitability for industrialized production, the almond perilla anti-cough syrup making is carried out to tinning, sealing, can sell patient's taking convenience.
In order to verify the curative effect of the made almond perilla anti-cough syrup of the present invention, further illustrate its beneficial effect by following contrast test:
1, strong aqua ammonia nebulization research almond perilla anti-cough syrup antitussive effect
Kunming mouse, body weight 18～22 g, male and female half and half, put in the airtight glass box of 4 L, evenly spray strong aqua ammonia aerosol to constant voltage in case with ultrasound atomizer, after 5 s, take out immediately, shrink and magnify or with coughing sound as index simultaneously taking mice abdominal muscle, observe and record cough number of times in mouse cough incubation period (being started to cough required time by spraying ammonia) and 2 min, after spraying, 2 not cough of min persons abandon.Qualified mice random packet after 2 days.
50 of qualified mices, arrange 5 groups: the high, medium and low dosage group of almond perilla anti-cough syrup, matched group (normal saline group).Every Mus gives medicinal liquid or normal saline by 0.2 mL/10 g, once a day, continuous 7 days, after last administration, 1 h puts mice respectively in airtight glass box, evenly sprays strong aqua ammonia aerosol with ultrasound atomizer to constant voltage in case, and spray time is about 10 s, spouting liquid approximately 3 mL, cause mouse cough reaction, record time and the interior mouse cough number of times of 2 min that cough appears in mice, test data represents with mean ± standard deviation.
Result of the test shows that the middle and high dosage group of almond perilla anti-cough syrup can obviously reduce mouse cough number of times; Meanwhile, high dose group, middle dosage group can obviously extend mice and draw and cough incubation period.In table 1.
Table 1
2, almond perilla anti-cough syrup phlegm-dispelling functions research
50 of mices, male and female half and half, body weight 18～22 g, are divided into 5 groups at random: the high, medium and low dosage group of almond perilla anti-cough syrup, matched group (normal saline group).Every Mus gives medicinal liquid or normal saline by 0.2 mL/10 g, once a day, continuous 7 days, after last administration after 30 min, phenol red physiological salt liquid 0.5 mL of every Mus lumbar injection 0.5%.Inject after phenol red liquid 30 min, de-cervical vertebra is put to death mice.Separate trachea, cut one section of trachea to trachea crotch from thyroid cartilage lower edge, put into the test tube of 2ml normal saline, after vortex oscillation device shakes 5 min, 20 min are washed in ultrasonic concussion, add 50 g/L sodium bicarbonate solution 1 mL, 1500 revs/min of centrifugal 10 min get supernatant, using 5% sodium bicarbonate as blank, in spectrophotometer, 546 nm places measure absorbance, with concentration known phenol red solution-absorbance regression equation calculation sample phenol red concentration.Test data represents with mean ± standard deviation.
Result of the test shows that almond perilla anti-cough syrup can increase phenol red output of mice.In table 2.
Table 2
3, almond perilla anti-cough syrup Study on Antiasthmatic
Kunming mouse, body weight 18～22g, male and female half and half, put in the airtight glass box of 4 L, with 2% acecoline and the quantitative constant-pressure atomization of 0.1% histamine mixed liquor (1:1) aerosol, after 5 s, take out immediately, record Cavia porcellus and start to exceed 120 s Cavia porcelluss incubation period and give up to occurring that panting property twitches the incubation period of falling, draw breathing heavily from accepting spraying.50 of qualified mices, male and female dual-purpose, is divided into 5 groups at random: the high, medium and low dosage group of almond perilla anti-cough syrup, matched group (normal saline group).Every Mus gives medicinal liquid or normal saline by 0.2 mL/10 g gavage, once a day, continuous 7 days, after last administration, 1 h puts mice respectively in the airtight glass box of volume 4 L, evenly sprays into 2% acecoline and 0.1% histamine mixed liquor (1:1) aerosol with ultrasound atomizer to constant voltage in case, and spray time is about 15 s, observing mice self-spray starts to asthma attack, dyspnea, until the time that tic is fallen breathes heavily incubation period as drawing, exceedes the 120 s persons of not falling and calculates by 120 s.Test data represents with mean ± standard deviation.
Result of the test shows that almond perilla anti-cough syrup high dose group, middle dosage group have obvious antiasthmatic effect.In table 3.
Table 3
4, almond perilla anti-cough syrup antiinflammatory action research
50 of mices, male and female half and half, body weight 18～22g, is divided into 5 groups at random: the high, medium and low dosage group of almond perilla anti-cough syrup, matched group (normal saline group).Every Mus gives medicinal liquid or positive drug by 0.2 mL/10 g, 1 h after administration, intravenous injection 0.5% azovan blue normal saline 0.1 mL/10 g, only, after 20 min, de-neck is put to death mice to lumbar injection 0.6% ethanol 0.2 mL/ immediately, cut off skin of abdomen muscle, divide and for several times wash abdominal cavity with 10 mL normal saline, suction pipe sucking-off cleaning mixture, after merging with 3000 revs/min of centrifugal 15 min, get supernatant and measure absorbance in 590 nm places, test data represents with mean ± standard deviation.
Result of the test shows that almond perilla anti-cough syrup high dose group can obviously suppress H
+induced mice abdominal cavity capillary tube blood vessel permeability increases.In table 4.Table 4
This test of pesticide effectiveness result has affirmed that almond perilla anti-cough syrup of the present invention has antitussive, eliminates the phlegm, relievings asthma and the effect of antiinflammatory, has significant curative effect to treatment chronic bronchitis.
Claims (1)
1. the preparation method of almond perilla anti-cough syrup, comprises the following steps:
(1) extraction of volatile oil: Folium Perillae 50 g are placed in boiling flask, the distilled water that adds 12～18 times of Folium Perillae weight, is connected to volatile oil extractor on boiling flask, adds water to overflowing in round-bottomed flask in the arm of volatile oil extractor, on connect spherical condensation tube, soak 1～3 h, then start vapor distillation, after 3～6 h, stop distillation, place 0.5～2 h, oil to volatile oil extractor is limpid, collects respectively volatile oil and carries the residue after oil, for subsequent use;
(2) water extraction: Radix Platycodonis 30 g, Semen Armeniacae Amarum 30 g, Radix Scutellariae 20 g, Herba Ephedrae 30 g, Bulbus Fritillariae Thunbergii 20 g are mixed with the residue that step (1) Folium Perillae is carried after oil, add the distilled water of 8～12 times of mixture total weight amounts, heating decocts 1～3 time, after each decoction 1～2 h, filter, merge filtrate, the filtrate after merging is staticly settled to rear absorption supernatant, obtain the first supernatant, again by the first supernatant concentrating under reduced pressure, staticly settle, again draw and obtain the second supernatant;
(3) mix: in the second supernatant, add simple syrup 60 mL, sodium benzoate 0.33 g, ethyl hydroxybenzoate 0.05 g, after mix homogeneously, boil, then the volatile oil that adds step (1) to collect, adding distil water to 100 mL, stirs evenly and obtains almond perilla anti-cough syrup.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1453026A (en) * | 2003-03-13 | 2003-11-05 | 红桃开集团股份有限公司 | Compound couth-relieving aster medicine and its prepn |
| CN1824097A (en) * | 2005-12-27 | 2006-08-30 | 广西桂西制药有限公司 | Chinese medicinal preparation for treating cough and its preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1453026A (en) * | 2003-03-13 | 2003-11-05 | 红桃开集团股份有限公司 | Compound couth-relieving aster medicine and its prepn |
| CN1824097A (en) * | 2005-12-27 | 2006-08-30 | 广西桂西制药有限公司 | Chinese medicinal preparation for treating cough and its preparation method |
Non-Patent Citations (2)
| Title |
|---|
| 张士勇等.杏苏止咳糖浆的药效学研究.《医药导报》.2012,第31卷(第1期),第10页左栏倒数第1-2段. |
| 杏苏止咳糖浆的药效学研究;张士勇等;《医药导报》;20120131;第31卷(第1期);第10页左栏倒数第1-2段 * |
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