CN103039992A - Composition for relieving fatigue and nutritious food thereof - Google Patents
Composition for relieving fatigue and nutritious food thereof Download PDFInfo
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- CN103039992A CN103039992A CN2013100246420A CN201310024642A CN103039992A CN 103039992 A CN103039992 A CN 103039992A CN 2013100246420 A CN2013100246420 A CN 2013100246420A CN 201310024642 A CN201310024642 A CN 201310024642A CN 103039992 A CN103039992 A CN 103039992A
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Abstract
The invention discloses a composition for relieving fatigue and a nutritious food of the composition. Based on part by weight, the composition comprises 5-10 of pawpaw ultrafine powder, 3-8 of polygonum cuspidate ultrafine powder and 4-9 of data ultrafine powder; and the formula of the composition is reasonable, and the raw materials are ultrafine powders and contain several functional components or functional factors of natural plants. The composition has high in-vivo biological utilization and good fatigue relief effect, and has the functions of enhancing the mitochondrial respiratory and ATP synthesis, maintaining the in-vivo oxidation-stress balance state, increasing muscle protein synthesis, restoring muscle electrophysiological excitability and improving the muscle metabolic capability.
Description
Technical field
The present invention relates to field of food, particularly a kind of composition of fatigue-relieving also relates to the nutraceutical that contains said composition.
Background technology
Fatigue is also referred to as " chronic fatigue syndrome " (CFS), shows as a kind of sense of discomfort of subjectivity.Modern's life pressure is large, and rhythm of life is fast, easily occurs tired.CFS symptom standard: the overweight fatigue that is difficult for releasing that causes of muscle power or mental load; The muscle weakness that does not have clear and definite reason; The insomnia ubiquity, or dreaminess and early awakening are arranged; Alliteration, giddy or headache; Absent minded, failure of memory; Poor appetite; Shoulder is uncomfortable, the chest girdle sensation, or lumbago is arranged, the myalgia of delocalization and arthralgia are without clear and definite rheumatism or trauma history; Interest is depressed, anxiety or anxiety, fear; Interest goes down or loses; Hypogona dism; Low-heat; There are girdle sensation in dry throat, pharyngalgia or throat.Have 2 main standard or add up simple symptom standard more than 8, can be diagnosed as CFS.The tired reason that occurs is more, had do more physical exercises, long time continuous working, stress, sleep deprivation, visual fatigue and Other diseases factor cause.After tired the generation, human body all exists some general character to change aspect physiology, biochemistry and the metabolism, increase such as the vivo oxidation stress level, free radical increases, the Muscle Mitochondria respiratory function descends and ATP generates minimizing, and myoelectrical activity weakens, and the muscle metabolism ability descends, immunologic function (comprising cellular immunity, the innate immunity and humoral immunity) reduces, abnormal glucose metabolism.Therefore, by improving particularly mitochondrial respiratory function of muscle metabolism, promote ATP synthetic, the balance the body oxidative stress status improves immunologic function and is and thinks at present the important channel of fatigue-relieving.
The curable product of fatigue-relieving or the main component of health food are medicine mostly at present, such as caffeine, by the human nerve mental symptom is alleviated in the adjusting of nervous system and internal system.Although have good fatigue-relieving effect, can't avoid the long-term drug side-effect that exists of using.
Summary of the invention
One of purpose of the present invention is to provide the composition of fatigue-relieving, and prescription is reasonable, good absorbing effect, and bioavilability is high.For achieving the above object, technical scheme is:
A kind of composition of fatigue-relieving comprises following component by weight:
Pawpaw Ultramicro-powder 5-10 part;
Giant knotweed Ultramicro-powder 3-8 part;
Date Ultramicro-powder 4-9 part.
Preferably, comprise by weight following component:
8 parts of pawpaw Ultramicro-powders;
5 parts of giant knotweed Ultramicro-powders;
6 parts of date Ultramicro-powders.
Preferably, also comprise by weight following component: taurine 0.3-1.0 part.
Preferred, also comprise by weight following component: 0.6 part of taurine.
Most preferred; comprise by weight following component: 20 parts of pawpaw Ultramicro-powders; 10 parts of giant knotweed Ultramicro-powders, 10 parts of date Ultramicro-powders, 0.6 part of taurine; 30 parts in carbohydrate; 2.1 parts of Valines, 2.7 parts of L-Leus, 1.7 parts of ILEs; 1.5 parts of L-arginines, 0.7 part of 0.7 part of Pidolidone and L-ASPARTIC ACID.
The particle diameter of pawpaw Ultramicro-powder, giant knotweed Ultramicro-powder and date Ultramicro-powder is the 2-3 micron among the present invention.
Two of purpose of the present invention is to provide the nutraceutical of the composition of fatigue-relieving, and technical scheme is:
The nutraceutical that contains the composition of described fatigue-relieving.
Beneficial effect of the present invention: the composition of fatigue-relieving disclosed by the invention, take pawpaw, giant knotweed and date Ultramicro-powder as primary raw material, prescription rationally contains multiple efficacies composition or function factor in the composition, and bioavilability is high in vivo; Said composition can also with other needed by human nutritional labeling assembly, form the fatigue-relieving nutraceutical; Contain multiple phytochemical with antifatigue biological effectiveness in the nutraceutical product, have and strengthen mitochondrial respiratory and ATP is synthetic, keep vivo oxidation-stress poised state, increase muscle protein synthetic, recover muscle electricity physiology excitability, improve muscle metabolism ability etc.
The preparation of Ultramicro-powder utilizes the technique that the air-flow crushing machinery of flash distillation and many times of velocities of sound (above 3.08 Mach) combines among the present invention, pawpaw particle behind the flash-evaporation dehydration is pulverized, fully make plant cell wall breaking, nutritive effect composition wherein can freely discharge at human body alimentary canal, need not pass through traditional making beating filter residue or enzymolysis and extraction juice, keep the original nutritional labeling of pawpaw and functional components, and all dietary fibers of fruit and the refining losses of antioxidant content minimum degree have been kept, this technique can reduce the particle diameter of pawpaw Ultramicro-powder greatly, and minimum grain size reaches 2 microns; In addition, the papaya powder of this technique preparation is different from traditional extraction drying powder of spraying, and process procedure is few, and is little to the antioxidant composition heat loss, keeps whole pawpaw dry components, and the effect activity is high, and need not add any processing aid.
The specific embodiment
In order to make the purpose, technical solutions and advantages of the present invention clearer, the below is described in detail the preferred embodiments of the present invention.
Raw material is processed:
The preparation of pawpaw Ultramicro-powder: pawpaw is made pulp with beater, flash distillation to water content is lower than 8% fast, then the granularity that is crushed to particle is less than 3mm, the pawpaw particle is lower than in temperature under-140 ℃ of conditions again and pulverizes by airslide disintegrating mill, the air velocity of airslide disintegrating mill is greater than 3.08 Mach, be crushed to granularity for less than 3 microns, get the pawpaw Ultramicro-powder.
The preparation of giant knotweed Ultramicro-powder: with giant knotweed beater homogenate, flash distillation to water content is lower than 8% fast, then the granularity that is crushed to particle is less than 3mm, the giant knotweed particle is lower than in temperature under-140 ℃ of conditions again and pulverizes by airslide disintegrating mill, the air velocity of airslide disintegrating mill is greater than 3.08 Mach, be crushed to granularity for less than 3 microns, get the giant knotweed Ultramicro-powder.
The preparation of date Ultramicro-powder: will make pulp with beater after the Removing Kernel for Date, flash distillation to water content is lower than 8% fast, then the granularity that is crushed to particle is less than 3mm, large jujube granule is lower than in temperature under-140 ℃ of conditions again and pulverizes by airslide disintegrating mill, the air velocity of airslide disintegrating mill is greater than 3.08 Mach, be crushed to granularity for less than 3 microns, get the date Ultramicro-powder.
Except using above-mentioned method to prepare Ultramicro-powder, also can use the additive method preparation of Ultramicro-powder, be that the 2-3 micron all can be realized goal of the invention as long as satisfy granularity.
Embodiment 1
A kind of composition of fatigue-relieving comprises by weight:
8 parts of pawpaw Ultramicro-powders;
5 parts of giant knotweed Ultramicro-powders;
6 parts of date Ultramicro-powders.
Said components is mixed in proportion, and to add general food filler ad pond om be 100 parts, get the fatigue-relieving nutraceutical.In the every 100g fatigue-relieving of the gained nutraceutical, contain pawpaw Ultramicro-powder 8g, giant knotweed Ultramicro-powder 5g, date Ultramicro-powder 6g.
Embodiment 2
A kind of composition of fatigue-relieving comprises by weight:
5 parts of pawpaw Ultramicro-powders;
3 parts of giant knotweed Ultramicro-powders;
4 parts of date Ultramicro-powders.
Said components is mixed in proportion, and to add general food filler ad pond om be 100 parts, get the fatigue-relieving nutraceutical.In the every 100g fatigue-relieving of the gained nutraceutical, contain pawpaw Ultramicro-powder 5g, giant knotweed Ultramicro-powder 3g, date Ultramicro-powder 4g.
Embodiment 3
A kind of composition of fatigue-relieving comprises by weight:
5 parts of pawpaw Ultramicro-powders;
8 parts of giant knotweed Ultramicro-powders;
9 parts of date Ultramicro-powders.
Said components is mixed in proportion, and to add general food filler ad pond om be 100 parts, get the fatigue-relieving nutraceutical.In the every 100g fatigue-relieving of the gained nutraceutical, contain pawpaw Ultramicro-powder 5g, giant knotweed Ultramicro-powder 8g, date Ultramicro-powder 9g.
Embodiment 4
A kind of fatigue-relieving composition comprises by weight:
10 parts of pawpaw Ultramicro-powders;
8 parts of giant knotweed Ultramicro-powders;
9 parts of date Ultramicro-powders;
0.3 part of taurine.
Said components is mixed in proportion, and adding general food filler ad pond om is 100 parts, gets the composition of fatigue-relieving.In the every 100g fatigue-relieving of the gained nutraceutical, contain pawpaw Ultramicro-powder 10g, giant knotweed Ultramicro-powder 8g, date Ultramicro-powder 9g and taurine 300mg.
Embodiment 5
A kind of composition of fatigue-relieving comprises by weight:
10 parts of pawpaw Ultramicro-powders;
8 parts of giant knotweed Ultramicro-powders;
4 parts of date Ultramicro-powders;
1 part of taurine.
Said components is mixed in proportion, and adding general food filler ad pond om is 100 parts, gets the composition of fatigue-relieving.In the every 100g fatigue-relieving of the gained nutraceutical, contain pawpaw Ultramicro-powder 10g, giant knotweed Ultramicro-powder 8g, date Ultramicro-powder 4g and taurine 1g.
Embodiment 6
A kind of composition of fatigue-relieving comprises by weight:
5 parts of pawpaw Ultramicro-powders;
8 parts of giant knotweed Ultramicro-powders;
9 parts of date Ultramicro-powders;
0.6 part of taurine.
Said components is mixed in proportion, and adding general food filler ad pond om is 100 parts, gets the composition of fatigue-relieving.In the every 100g fatigue-relieving of the gained nutraceutical, contain pawpaw Ultramicro-powder 5g, giant knotweed Ultramicro-powder 8g, date Ultramicro-powder 9g and taurine 600mg.
Embodiment 7
A kind of composition of fatigue-relieving; comprise by weight: 5 parts of pawpaw Ultramicro-powders; 8 parts of giant knotweed Ultramicro-powders, 9 parts of date Ultramicro-powders, 1 part of taurine; 30 parts in carbohydrate; 2.1 parts of Valines, 2.7 parts of L-Leus, 1.7 parts of ILEs; 1.5 parts of L-arginines, 0.7 part of 0.7 part of Pidolidone and L-ASPARTIC ACID.
Said components is mixed in proportion, and adding general food filler ad pond om is 100 parts, gets the composition of fatigue-relieving.In the every 100g fatigue-relieving of the gained nutraceutical, contain pawpaw Ultramicro-powder 5g, giant knotweed Ultramicro-powder 8g, date Ultramicro-powder 9g; taurine 1g, carbohydrate 30g, Valine 2.1g, L-Leu 2.7g; ILE 1.7g, L-arginine 1.5g, Pidolidone 0.7g and L-ASPARTIC ACID 0.7g.
Embodiment 8
A kind of composition of fatigue-relieving contains pawpaw Ultramicro-powder 10g in the 100g composition, giant knotweed Ultramicro-powder 3g; date Ultramicro-powder 6g, taurine 300mg, carbohydrate 30g; Valine 2.1g, L-Leu 2.7g, ILE 1.7g; L-arginine 1.5g, Pidolidone 0.7g, L-ASPARTIC ACID 0.7g; vitamin B1 0.35mg, vitamin B2 0.35mg, vitamin B6 0.3mg; vitamin C 7mg, pantothenic acid 1mg, nicotinic acid 1.5mg; biotin 25 μ g; sodium 45 mg, potassium 16 mg, calcium 72 mg; phosphorus 80mg; chlorine 215 mg, iron 1.3mg and zinc 5 mg, surplus is food filler commonly used.
Food filler commonly used among the present invention can be starch, and animal protein or vegetable protein also can be antioxidant or fumet commonly used in the food.
In the composition of the fatigue-relieving of embodiment 1-3, pawpaw contains pawpaw polyphenol, oleanolic acid, organic acid and flavone compound, be called as " hundred benefits are fruit ", " emperor of fruit ", " ten thousand longevity melons ", the effect of reinforcing spleen to promote digestion, anti-epidemic disease desinsection, removing heat to expel wind, liver protecting is arranged.Be rich in jujube polysaccharide, jujube CAMP, jujube triterpenic acid, dietary fiber in the date, can improve liver metabolism and digestive function, enhance strong immunity, improve endocrine, antifatigue, Traditional Chinese medical theory thinks that date can tonifying middle-Jiao and Qi, nourishing blood and tranquilization, be used for insufficiency of the spleen food few, weak loose stool.Giant knotweed contains abundant polyphenolic plant chemicals-resveratrol as important Chinese medicine food materials, and resveratrol has multiple significant biological effectiveness, comprises antitumor, cardiovascular protection, anti-ageing, balance the body substance metabolism functions.
Added taurine in the composition of the fatigue-relieving of embodiment 4-6 as a seed amino acid, improved retinal function, played a significant role in the alleviation visual fatigue.
Utilize the fatigue-relieving nutraceutical of embodiment 1 preparation that the BABL/c mouse is carried out zoopery, be divided into 4 groups, 8 every group.Experiment grouping: this product intervention group of various dose (100mg/ days, 200mg/ days, 400mg/ days) and control group, intervention time detects index after 7 days: (1) Loaned swimming test, reaction physical fatigue; (2) Morris water maze laboratory, reaction cognitive function and mental fatigue.The Loaned swimming test result is as shown in table 1:
Table 1 mouse swimming power exhausts the time
| Group | Dosage (mg/ days) | Swimming time (s) | Rate elongation (%) |
| Control group | / | 215.3±17.5 | / |
| Low dose group | 100 | 261.7±27.0 * | 21.5 |
| Middle dosage group | 200 | 308.7±17.4 ** | 43.4 |
| High dose exists | 400 | 329.0±13.5 ** | 52.8 |
Annotate:
*P＜0.05,
*(Mean ± S.E. M., n=8) compared with control group in P＜0.01
As shown in Table 1, intervene a week after, with control group relatively, the animal swimming power time that exhausts obviously prolongs, basic, normal, high dosage group rate elongation is respectively 21.5%, 43.4% and 52.8%.
The result is as shown in table 2 for the Morris water maze laboratory:
Table 2 orientation navigation is tested incubation period
| Group | Dosage (mg/ days) | The 1st day | The 2nd day | The 3rd day | The 4th day | The 5th day |
| Control group | / | 45.2±3.5 | 30.1±5.5 | 31.2±3.8 | 25.8±1.3 | 22.6±1.6 |
| Low dose group | 100 | 43.1±2.0 | 29.8±1.9 | 17.9±3.5 * | 16.6±1.3 * | 15.5±1.1 * |
| Middle dosage group | 200 | 42.2±4.3 | 26.2±2.3 | 16.5±2.0 ** | 13.2±0.8 ** | 10.4±0.9 ** |
| High dose group | 400 | 41.5±3.5 | 25.6±4.0 * | 13.3±1.7 ** | 11.4±1.5 ** | 9.8±1.0 ** |
Annotate:
*P＜0.05,
*(Mean ± S.E. M., n=8) compared with while phase point control group in P＜0.01
As shown in Table 2, compare with control group, rose in the 2nd day, the orientation navigation time of high dose group significantly descends, and the result has statistical significance (P＜0.05); From the 3rd day, the orientation navigation time of basic, normal, high dosage group all significantly descended, and the result has statistical significance (P＜0.05).Brainfag is effectively restored after the bearing reaction mouse invented food.
In sum, the fatigue-relieving nutraceutical of the present invention's preparation can alleviating physical fatigue and mental fatigue.Usage and consumption: oral and tube feed all can, take after reconstituting with warm water.Every 50g adds warm water 200mL, stirring and dissolving.Use as the general population, the suggestion consumption is each 10g, and is one day 2 times, once particularly important before sleeping.Special operating personnel can a 20g, one day 2 times.
Explanation is at last, above embodiment is only unrestricted in order to technical scheme of the present invention to be described, although by invention has been described with reference to the preferred embodiments of the present invention, but those of ordinary skill in the art is to be understood that, can make various changes to it in the form and details, and not depart from the spirit and scope of the present invention that appended claims limits.
Claims (6)
1. the composition of a fatigue-relieving is characterized in that, comprises by weight following component:
Pawpaw Ultramicro-powder 5-10 part;
Giant knotweed Ultramicro-powder 3-8 part;
Date Ultramicro-powder 4-9 part.
2. the composition of described fatigue-relieving according to claim 1 is characterized in that, comprises by weight following component:
8 parts of pawpaw Ultramicro-powders;
5 parts of giant knotweed Ultramicro-powders;
6 parts of date Ultramicro-powders.
3. the composition of described fatigue-relieving according to claim 1 is characterized in that, also comprises by weight following component: taurine 0.3-1.0 part.
4. the composition of described fatigue-relieving according to claim 3 is characterized in that, also comprises by weight following component: 0.6 part of taurine.
5. the composition of each described fatigue-relieving according to claim 1-4; it is characterized in that, comprise by weight following component: 20 parts of pawpaw Ultramicro-powders, 10 parts of giant knotweed Ultramicro-powders; 10 parts of date Ultramicro-powders; 0.6 part of taurine, 30 parts in carbohydrate, 2.1 parts of Valines; 2.7 parts of L-Leus; 1.7 parts of ILEs, 1.5 parts of L-arginines, 0.7 part of 0.7 part of Pidolidone and L-ASPARTIC ACID.
6. the nutraceutical that contains the composition of each described fatigue-relieving of claim 1-5.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101954070A (en) * | 2009-07-13 | 2011-01-26 | 陈洁 | Preparation method of composition of nano SOD and vegetable drugs and health-care food or extracts thereof |
| CN101669938B (en) * | 2008-09-11 | 2012-07-11 | 上海体育科学研究所 | Nutrient composition for eliminating exercise-induced fatigue |
| CN101856122B (en) * | 2010-05-25 | 2012-12-19 | 中国人民解放军第三军医大学 | Anti-fatigue composite nutrient and preparation method thereof |
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2013
- 2013-01-23 CN CN2013100246420A patent/CN103039992A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101669938B (en) * | 2008-09-11 | 2012-07-11 | 上海体育科学研究所 | Nutrient composition for eliminating exercise-induced fatigue |
| CN101954070A (en) * | 2009-07-13 | 2011-01-26 | 陈洁 | Preparation method of composition of nano SOD and vegetable drugs and health-care food or extracts thereof |
| CN101856122B (en) * | 2010-05-25 | 2012-12-19 | 中国人民解放军第三军医大学 | Anti-fatigue composite nutrient and preparation method thereof |
Non-Patent Citations (2)
| Title |
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| 刘艳等: "白藜芦醇生物学作用及其在抗运动性疲劳中的应用前景", 《中国临床康复》, vol. 10, no. 19, 20 May 2006 (2006-05-20) * |
| 钱丽丽等: "试论中医缓解体力疲劳保健食品的特色", 《山西中医》, vol. 25, no. 3, 31 March 2009 (2009-03-31) * |
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Application publication date: 20130417 |