CN103025733B - 碳青霉烯类衍生物或其水合物的晶型及其制备方法与用途 - Google Patents
碳青霉烯类衍生物或其水合物的晶型及其制备方法与用途 Download PDFInfo
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- CN103025733B CN103025733B CN201180026651.2A CN201180026651A CN103025733B CN 103025733 B CN103025733 B CN 103025733B CN 201180026651 A CN201180026651 A CN 201180026651A CN 103025733 B CN103025733 B CN 103025733B
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- DMJNNHOOLUXYBV-PQTSNVLCSA-N meropenem Chemical compound C=1([C@H](C)[C@@H]2[C@H](C(N2C=1C(O)=O)=O)[C@H](O)C)S[C@@H]1CN[C@H](C(=O)N(C)C)C1 DMJNNHOOLUXYBV-PQTSNVLCSA-N 0.000 description 1
- 229960002260 meropenem Drugs 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000011812 mixed powder Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 229940038384 octadecane Drugs 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000004260 plant-type cell wall biogenesis Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- FVSKHRXBFJPNKK-UHFFFAOYSA-N propionitrile Chemical compound CCC#N FVSKHRXBFJPNKK-UHFFFAOYSA-N 0.000 description 1
- 238000012207 quantitative assay Methods 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 150000003952 β-lactams Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Description
Claims (15)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201180026651.2A CN103025733B (zh) | 2010-06-03 | 2011-06-01 | 碳青霉烯类衍生物或其水合物的晶型及其制备方法与用途 |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
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CN201010190636.9 | 2010-06-03 | ||
CN 201010190636 CN102267996A (zh) | 2010-06-03 | 2010-06-03 | 碳青霉烯类衍生物或其水合物的晶型及其制备方法 |
CN2010101906369 | 2010-06-03 | ||
CN201110104082.0 | 2011-04-25 | ||
CN2011101040820 | 2011-04-25 | ||
CN201110104082 | 2011-04-25 | ||
PCT/CN2011/000925 WO2011150679A1 (zh) | 2010-06-03 | 2011-06-01 | 碳青霉烯类衍生物或其水合物的晶型及其制备方法与用途 |
CN201180026651.2A CN103025733B (zh) | 2010-06-03 | 2011-06-01 | 碳青霉烯类衍生物或其水合物的晶型及其制备方法与用途 |
Publications (2)
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CN103025733A CN103025733A (zh) | 2013-04-03 |
CN103025733B true CN103025733B (zh) | 2015-11-25 |
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CN201180026651.2A Active CN103025733B (zh) | 2010-06-03 | 2011-06-01 | 碳青霉烯类衍生物或其水合物的晶型及其制备方法与用途 |
Country Status (4)
Country | Link |
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US (1) | US8822445B2 (zh) |
CN (1) | CN103025733B (zh) |
HK (1) | HK1179616A1 (zh) |
WO (1) | WO2011150679A1 (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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US8318716B2 (en) * | 2009-12-31 | 2012-11-27 | Kbp Biosciences Co., Ltd. | Carbapenem derivatives |
CN102918041A (zh) * | 2010-05-21 | 2013-02-06 | 山东轩竹医药科技有限公司 | 碳青霉烯衍生物或其水合物的晶型及其制备方法与用途 |
US9840506B2 (en) | 2014-04-28 | 2017-12-12 | Jw Pharmaceutical Corporation | Crystal of doripenem, and preparation method therefor |
Citations (7)
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CN1372560A (zh) * | 1999-07-06 | 2002-10-02 | 三共株式会社 | 结晶性1-甲基碳青霉烯化合物 |
CN1432016A (zh) * | 2000-03-31 | 2003-07-23 | 盐野义制药株式会社 | 吡咯烷硫卡培南衍生物的新型结晶 |
CN1486318A (zh) * | 2001-01-16 | 2004-03-31 | 用于碳青霉烯合成的改进方法 | |
CN101119997A (zh) * | 2005-02-15 | 2008-02-06 | 盐野义制药株式会社 | 碳青霉烯衍生物的制备方法及其中间体结晶 |
CN101180271A (zh) * | 2005-03-22 | 2008-05-14 | 第一三共株式会社 | 具有1-烷基吡咯烷结构的碳青霉烯衍生物的制备方法 |
CN101372489A (zh) * | 2007-06-28 | 2009-02-25 | 山东轩竹医药科技有限公司 | 含有巯基吡咯烷甲酰胺苄基的碳青霉烯衍生物 |
CN102250095A (zh) * | 2010-05-21 | 2011-11-23 | 山东轩竹医药科技有限公司 | 碳青霉烯衍生物或其水合物的晶型及其制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8318716B2 (en) * | 2009-12-31 | 2012-11-27 | Kbp Biosciences Co., Ltd. | Carbapenem derivatives |
CN102918041A (zh) * | 2010-05-21 | 2013-02-06 | 山东轩竹医药科技有限公司 | 碳青霉烯衍生物或其水合物的晶型及其制备方法与用途 |
-
2011
- 2011-06-01 WO PCT/CN2011/000925 patent/WO2011150679A1/zh active Application Filing
- 2011-06-01 CN CN201180026651.2A patent/CN103025733B/zh active Active
- 2011-06-01 US US13/701,704 patent/US8822445B2/en active Active
-
2013
- 2013-06-06 HK HK13106724.5A patent/HK1179616A1/zh unknown
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CN1372560A (zh) * | 1999-07-06 | 2002-10-02 | 三共株式会社 | 结晶性1-甲基碳青霉烯化合物 |
CN1432016A (zh) * | 2000-03-31 | 2003-07-23 | 盐野义制药株式会社 | 吡咯烷硫卡培南衍生物的新型结晶 |
CN1486318A (zh) * | 2001-01-16 | 2004-03-31 | 用于碳青霉烯合成的改进方法 | |
CN101119997A (zh) * | 2005-02-15 | 2008-02-06 | 盐野义制药株式会社 | 碳青霉烯衍生物的制备方法及其中间体结晶 |
CN101180271A (zh) * | 2005-03-22 | 2008-05-14 | 第一三共株式会社 | 具有1-烷基吡咯烷结构的碳青霉烯衍生物的制备方法 |
CN101372489A (zh) * | 2007-06-28 | 2009-02-25 | 山东轩竹医药科技有限公司 | 含有巯基吡咯烷甲酰胺苄基的碳青霉烯衍生物 |
CN102250095A (zh) * | 2010-05-21 | 2011-11-23 | 山东轩竹医药科技有限公司 | 碳青霉烯衍生物或其水合物的晶型及其制备方法 |
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Also Published As
Publication number | Publication date |
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CN103025733A (zh) | 2013-04-03 |
HK1179616A1 (zh) | 2013-10-04 |
WO2011150679A1 (zh) | 2011-12-08 |
US8822445B2 (en) | 2014-09-02 |
US20130090325A1 (en) | 2013-04-11 |
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