CN102918041A - 碳青霉烯衍生物或其水合物的晶型及其制备方法与用途 - Google Patents
碳青霉烯衍生物或其水合物的晶型及其制备方法与用途 Download PDFInfo
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- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical class [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 206010041925 Staphylococcal infections Diseases 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 description 1
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- HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical compound OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 description 1
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- 239000012895 dilution Substances 0.000 description 1
- IEJIGPNLZYLLBP-UHFFFAOYSA-N dimethyl carbonate Chemical compound COC(=O)OC IEJIGPNLZYLLBP-UHFFFAOYSA-N 0.000 description 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 150000002118 epoxides Chemical class 0.000 description 1
- FCZCIXQGZOUIDN-UHFFFAOYSA-N ethyl 2-diethoxyphosphinothioyloxyacetate Chemical compound CCOC(=O)COP(=S)(OCC)OCC FCZCIXQGZOUIDN-UHFFFAOYSA-N 0.000 description 1
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- 238000010438 heat treatment Methods 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
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- 239000007791 liquid phase Substances 0.000 description 1
- 229960002721 mafenide acetate Drugs 0.000 description 1
- DMJNNHOOLUXYBV-PQTSNVLCSA-N meropenem Chemical compound C=1([C@H](C)[C@@H]2[C@H](C(N2C=1C(O)=O)=O)[C@H](O)C)S[C@@H]1CN[C@H](C(=O)N(C)C)C1 DMJNNHOOLUXYBV-PQTSNVLCSA-N 0.000 description 1
- 229960002260 meropenem Drugs 0.000 description 1
- 208000015688 methicillin-resistant staphylococcus aureus infectious disease Diseases 0.000 description 1
- UZKWTJUDCOPSNM-UHFFFAOYSA-N methoxybenzene Substances CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 description 1
- 239000011812 mixed powder Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- KVBGVZZKJNLNJU-UHFFFAOYSA-N naphthalene-2-sulfonic acid Chemical class C1=CC=CC2=CC(S(=O)(=O)O)=CC=C21 KVBGVZZKJNLNJU-UHFFFAOYSA-N 0.000 description 1
- 230000007135 neurotoxicity Effects 0.000 description 1
- 231100000228 neurotoxicity Toxicity 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 230000004260 plant-type cell wall biogenesis Effects 0.000 description 1
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- 238000012545 processing Methods 0.000 description 1
- 150000003235 pyrrolidines Chemical class 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
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- 239000002689 soil Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 239000002132 β-lactam antibiotic Substances 0.000 description 1
- 229940124586 β-lactam antibiotics Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
公开了一种式(I)所示的碳青霉烯类衍生物(4R，5S，6S)-3-[(3S，5S)-5-[(4-氨基磺酰基苯-1-基甲基)胺甲酰基]-3-吡咯烷基]硫基-6-[(R)-1-羟乙基]-4-甲基-7-氧代-1-氮杂双环[320]庚-2-烯-2-羧酸或其水合物的晶型，其制备方法，其在制备用于治疗和/或预防感染性疾病的药物中的应用，以及包含该晶型的药物组合物。
Description
PCT国内申请，说明书已公开。
Claims (1)
- PCT国内申请，权利要求书已公开。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011800253620A CN102918041A (zh) | 2010-05-21 | 2011-05-20 | 碳青霉烯衍生物或其水合物的晶型及其制备方法与用途 |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010178970 CN102250095A (zh) | 2010-05-21 | 2010-05-21 | 碳青霉烯衍生物或其水合物的晶型及其制备方法 |
| CN201010178970.2 | 2010-05-21 | ||
| CN201110104082.0 | 2011-04-25 | ||
| CN201110104082 | 2011-04-25 | ||
| PCT/CN2011/000874 WO2011143935A1 (zh) | 2010-05-21 | 2011-05-20 | 碳青霉烯衍生物或其水合物的晶型及其制备方法与用途 |
| CN2011800253620A CN102918041A (zh) | 2010-05-21 | 2011-05-20 | 碳青霉烯衍生物或其水合物的晶型及其制备方法与用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102918041A true CN102918041A (zh) | 2013-02-06 |
Family
ID=44991188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011800253620A Pending CN102918041A (zh) | 2010-05-21 | 2011-05-20 | 碳青霉烯衍生物或其水合物的晶型及其制备方法与用途 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US20130079322A1 (zh) |
| CN (1) | CN102918041A (zh) |
| WO (1) | WO2011143935A1 (zh) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8318716B2 (en) * | 2009-12-31 | 2012-11-27 | Kbp Biosciences Co., Ltd. | Carbapenem derivatives |
| WO2011150679A1 (zh) * | 2010-06-03 | 2011-12-08 | 山东轩竹医药科技有限公司 | 碳青霉烯类衍生物或其水合物的晶型及其制备方法与用途 |
| WO2015167148A1 (ko) * | 2014-04-28 | 2015-11-05 | 제이더블유중외제약 주식회사 | 도리페넴의 신규한 결정 및 이의 제조방법 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1259949A (zh) * | 1997-06-16 | 2000-07-12 | 麦克公司 | 稳定化碳青霉烯中间体及其合成用途 |
| CN1372560A (zh) * | 1999-07-06 | 2002-10-02 | 三共株式会社 | 结晶性1－甲基碳青霉烯化合物 |
| US20040063931A1 (en) * | 2001-01-16 | 2004-04-01 | William John M. | Process for carbapenem synthesis |
| CN101372489A (zh) * | 2007-06-28 | 2009-02-25 | 山东轩竹医药科技有限公司 | 含有巯基吡咯烷甲酰胺苄基的碳青霉烯衍生物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101333218B (zh) * | 2007-06-28 | 2011-05-18 | 山东轩竹医药科技有限公司 | 甲酰胺烷基苯取代的巯基吡咯烷碳青霉烯化合物 |
| US8318716B2 (en) * | 2009-12-31 | 2012-11-27 | Kbp Biosciences Co., Ltd. | Carbapenem derivatives |
| WO2011150679A1 (zh) * | 2010-06-03 | 2011-12-08 | 山东轩竹医药科技有限公司 | 碳青霉烯类衍生物或其水合物的晶型及其制备方法与用途 |
-
2011
- 2011-05-20 WO PCT/CN2011/000874 patent/WO2011143935A1/zh active Application Filing
- 2011-05-20 CN CN2011800253620A patent/CN102918041A/zh active Pending
- 2011-05-20 US US13/699,550 patent/US20130079322A1/en not_active Abandoned
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1259949A (zh) * | 1997-06-16 | 2000-07-12 | 麦克公司 | 稳定化碳青霉烯中间体及其合成用途 |
| CN1372560A (zh) * | 1999-07-06 | 2002-10-02 | 三共株式会社 | 结晶性1－甲基碳青霉烯化合物 |
| US20040063931A1 (en) * | 2001-01-16 | 2004-04-01 | William John M. | Process for carbapenem synthesis |
| CN101372489A (zh) * | 2007-06-28 | 2009-02-25 | 山东轩竹医药科技有限公司 | 含有巯基吡咯烷甲酰胺苄基的碳青霉烯衍生物 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20130079322A1 (en) | 2013-03-28 |
| WO2011143935A1 (zh) | 2011-11-24 |
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