CN102993214B - 一种头孢菌素的脱色方法 - Google Patents
一种头孢菌素的脱色方法 Download PDFInfo
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- CN102993214B CN102993214B CN201210521746.8A CN201210521746A CN102993214B CN 102993214 B CN102993214 B CN 102993214B CN 201210521746 A CN201210521746 A CN 201210521746A CN 102993214 B CN102993214 B CN 102993214B
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- exchange resin
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- 238000000034 method Methods 0.000 title claims abstract description 33
- 229930186147 Cephalosporin Natural products 0.000 title abstract description 8
- 229940124587 cephalosporin Drugs 0.000 title abstract description 8
- 150000001780 cephalosporins Chemical class 0.000 title abstract description 8
- 229920005989 resin Polymers 0.000 claims abstract description 97
- 239000011347 resin Substances 0.000 claims abstract description 97
- 239000007788 liquid Substances 0.000 claims abstract description 35
- 239000003957 anion exchange resin Substances 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims abstract description 15
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims abstract description 8
- 235000015497 potassium bicarbonate Nutrition 0.000 claims abstract description 8
- 239000011736 potassium bicarbonate Substances 0.000 claims abstract description 8
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims abstract description 8
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000001257 hydrogen Substances 0.000 claims description 34
- 229910052739 hydrogen Inorganic materials 0.000 claims description 34
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims description 28
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 27
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 24
- 230000008929 regeneration Effects 0.000 claims description 20
- 238000011069 regeneration method Methods 0.000 claims description 20
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 18
- 239000008367 deionised water Substances 0.000 claims description 18
- 229910021641 deionized water Inorganic materials 0.000 claims description 18
- 230000007704 transition Effects 0.000 claims description 16
- 239000003463 adsorbent Substances 0.000 claims description 15
- 235000012538 ammonium bicarbonate Nutrition 0.000 claims description 10
- -1 carbonic acid Hydrogen Chemical class 0.000 claims description 8
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 8
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 8
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 claims description 5
- 229910000013 Ammonium bicarbonate Inorganic materials 0.000 claims description 5
- 239000001099 ammonium carbonate Substances 0.000 claims description 5
- 238000004061 bleaching Methods 0.000 claims description 3
- 238000001179 sorption measurement Methods 0.000 claims description 3
- 125000001302 tertiary amino group Chemical group 0.000 claims description 3
- 230000000274 adsorptive effect Effects 0.000 claims description 2
- 239000000049 pigment Substances 0.000 claims description 2
- 229920006395 saturated elastomer Polymers 0.000 claims description 2
- 125000000524 functional group Chemical group 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract description 75
- 230000000694 effects Effects 0.000 abstract description 12
- 230000002255 enzymatic effect Effects 0.000 abstract description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract description 5
- 230000008901 benefit Effects 0.000 abstract description 3
- 238000005336 cracking Methods 0.000 abstract 1
- 230000001131 transforming effect Effects 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
- 238000002834 transmittance Methods 0.000 description 15
- 229920001429 chelating resin Polymers 0.000 description 12
- 150000001450 anions Chemical class 0.000 description 8
- 238000003776 cleavage reaction Methods 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- 230000007017 scission Effects 0.000 description 7
- 230000007613 environmental effect Effects 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 4
- 238000004587 chromatography analysis Methods 0.000 description 4
- 239000003456 ion exchange resin Substances 0.000 description 4
- 229920003303 ion-exchange polymer Polymers 0.000 description 4
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 3
- HSHGZXNAXBPPDL-HZGVNTEJSA-N 7beta-aminocephalosporanic acid Chemical compound S1CC(COC(=O)C)=C(C([O-])=O)N2C(=O)[C@@H]([NH3+])[C@@H]12 HSHGZXNAXBPPDL-HZGVNTEJSA-N 0.000 description 3
- NVIAYEIXYQCDAN-CLZZGJSISA-N 7beta-aminodeacetoxycephalosporanic acid Chemical compound S1CC(C)=C(C(O)=O)N2C(=O)[C@@H](N)[C@@H]12 NVIAYEIXYQCDAN-CLZZGJSISA-N 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 230000001276 controlling effect Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 238000007634 remodeling Methods 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 108010010803 Gelatin Proteins 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 238000011426 transformation method Methods 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 238000004042 decolorization Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000001728 nano-filtration Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000011017 operating method Methods 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 229960004249 sodium acetate Drugs 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000003245 working effect Effects 0.000 description 1
- 150000003952 β-lactams Chemical class 0.000 description 1
Landscapes
- Treatment Of Liquids With Adsorbents In General (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (7)
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CN201210521746.8A CN102993214B (zh) | 2012-12-07 | 2012-12-07 | 一种头孢菌素的脱色方法 |
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CN201210521746.8A CN102993214B (zh) | 2012-12-07 | 2012-12-07 | 一种头孢菌素的脱色方法 |
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CN102993214A CN102993214A (zh) | 2013-03-27 |
CN102993214B true CN102993214B (zh) | 2015-01-28 |
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Families Citing this family (1)
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CN117599860B (zh) * | 2024-01-23 | 2024-03-26 | 欧尚元智能装备有限公司 | 一种头孢脱色***及工艺 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3983108A (en) * | 1975-02-10 | 1976-09-28 | Merck & Co., Inc. | Antibiotic purification process |
US4205165A (en) * | 1977-12-06 | 1980-05-27 | Glaxo Group Limited | Processing of cephalosporin C |
EP0167651A1 (en) * | 1983-05-09 | 1986-01-15 | Antibioticos, S.A. | Process for producing 3-cephem-4-carboxylic acid derivatives substituted in 3-position |
CN1531539A (zh) * | 2001-04-19 | 2004-09-22 | ��ŷ�����¶����ǹɷ�����˾ | 用α-酮酸衍生物制备头孢烷酸衍生物的酶促方法 |
CN101875660A (zh) * | 2009-04-29 | 2010-11-03 | 上海医药工业研究院 | 从头孢菌素c发酵液中分离纯化脱乙酰头孢菌素c的方法 |
-
2012
- 2012-12-07 CN CN201210521746.8A patent/CN102993214B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3983108A (en) * | 1975-02-10 | 1976-09-28 | Merck & Co., Inc. | Antibiotic purification process |
US4205165A (en) * | 1977-12-06 | 1980-05-27 | Glaxo Group Limited | Processing of cephalosporin C |
EP0167651A1 (en) * | 1983-05-09 | 1986-01-15 | Antibioticos, S.A. | Process for producing 3-cephem-4-carboxylic acid derivatives substituted in 3-position |
CN1531539A (zh) * | 2001-04-19 | 2004-09-22 | ��ŷ�����¶����ǹɷ�����˾ | 用α-酮酸衍生物制备头孢烷酸衍生物的酶促方法 |
CN101875660A (zh) * | 2009-04-29 | 2010-11-03 | 上海医药工业研究院 | 从头孢菌素c发酵液中分离纯化脱乙酰头孢菌素c的方法 |
Non-Patent Citations (6)
Title |
---|
Mixed-Mode Anion-Cation Exchange/Hydrophilic Interaction Liquid Chromatography-Electrospray Mass Spectrometry as an Alternative to Reversed Phase for Small Molecule Drug Discovery;Mark A. Strege,等;《Anal. Chem.》;20000824;第72卷(第19期);第4629-4633页,参见全文 * |
于海军.去乙酰头孢菌素C的分离及相关化合物的合成.《天津大学博士学位论文》.2007,正文第20页第2-3段. * |
去乙酰头孢菌素C的分离及相关化合物的合成;于海军;《天津大学博士学位论文》;20070515;正文第20页第2-3段 * |
头孢菌素C生产工艺改进的研究V.大孔树脂吸附法提取头孢菌素C;赵凤生,等;《医药工业》;19871028;第18卷(第10期);第440页3,4部分 * |
用离子交换纯化明胶的一些建议;张涛,等;《明胶科学与技术》;20050930;第25卷(第3期);第153页右栏2部分 * |
赵凤生,等.头孢菌素C生产工艺改进的研究V.大孔树脂吸附法提取头孢菌素C.《医药工业》.1987,第18卷(第10期),第440页3,4部分. * |
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Effective date of registration: 20190320 Address after: 510000 self compiled G1-201, 39 Rui he road, Whampoa District, Guangzhou, Guangdong Patentee after: GUANGZHOU LIXIN PHARMACEUTICALS CO.,LTD. Address before: No. 229 Taibai Road, Xi'an, Shaanxi, Shaanxi Patentee before: Northwest University |
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Denomination of invention: Method for decoloring cephalosporin Effective date of registration: 20190628 Granted publication date: 20150128 Pledgee: Senbao Branch of Guangzhou Bank Co.,Ltd. Pledgor: GUANGZHOU LIXIN PHARMACEUTICALS CO.,LTD. Registration number: 2019440000243 |
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Denomination of invention: A decolorization method of cephalosporins Effective date of registration: 20200813 Granted publication date: 20150128 Pledgee: Senbao Branch of Guangzhou Bank Co.,Ltd. Pledgor: GUANGZHOU LIXIN PHARMACEUTICALS Co.,Ltd. Registration number: Y2020440000231 |
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Denomination of invention: A decolorization method of cephalosporin Effective date of registration: 20210830 Granted publication date: 20150128 Pledgee: Tianhe sub branch of Bank of Guangzhou Co.,Ltd. Pledgor: GUANGZHOU LIXIN PHARMACEUTICALS Co.,Ltd. Registration number: Y2021980008655 |
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