CN102961786A - Porous silicon rubber film for artificial skin - Google Patents
Porous silicon rubber film for artificial skin Download PDFInfo
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- CN102961786A CN102961786A CN2012104904966A CN201210490496A CN102961786A CN 102961786 A CN102961786 A CN 102961786A CN 2012104904966 A CN2012104904966 A CN 2012104904966A CN 201210490496 A CN201210490496 A CN 201210490496A CN 102961786 A CN102961786 A CN 102961786A
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Abstract
The invention discloses a porous silicon rubber film for artificial skin and a preparation method thereof. The preparation method is characterized by comprising the following steps of: adding a silicon rubber precursor, a non-solvent or a pore-foaming agent and a volatile solvent into a mixer provided with a stirrer and a thermometer in a certain proportion, and stirring for 10-20 minutes at the room temperature or dispersing for 5-10 minutes by using an ultrasonic wave of 200-300W to obtain a film-forming solution; standing to defoam the film-forming solution for 3-6 hours or defoaming the film-forming solution for 20-50 minutes at a vacuum degree of 0.6-0.8MPa, and then spin-coating or blade-coating the solution on a template to form the film or curtain-coating the solution in a die to form the film; then standing the template or the die for 2-60min at a temperature of 25-60 DEG C, and removing the solvent in the liquid film through volatilization; curing and shaping the silicon rubber precursor with the non-solvent or the pore-foaming agent after the removal of the solvent at a temperature of 100-150 DEG C; and removing the non-solvent or the pore-foaming agent in the cured silicon rubber film by soaking or extracting the solvent for 3-4 days, wherein the solvent is changed each day in the soaking or extracting process. The bore diameter of the prepared porous silicon rubber film ranges from 500 nanometers to 140 microns, and the prepared porous silicon rubber film is used for manufacturing the artificial skin.
Description
Technical field
The invention belongs to the material applied technical field, be specifically related to a kind of porous silicon rubber film for artificial skin.
Background technology
Skin is the organ of human body maximum, is the natural cover for defense of protection body.For serious skin injury patient, a large amount of losses of body fluid and wound infection are the principal elements that threatens patient's life.Prepare a kind of have some strength, toughness, the waterproof and breathable performance seems particularly important near the artificial skin of real skin, can alleviate patient's misery, saves patient's life.
Medical grade silicon rubber, have higher temperature tolerance, resistance to oxidation, hydrophobicity, flexibility, permeability, ageing-resistant transparency height, physiology inertia, with a series of good characteristics such as tissue and blood adhesion, biocompatibility be good, nontoxic, tasteless, not carcinogenic.The medical products such as the artificial peritoneum of preparation, artificial knuckle, soft tissue expander, artificial skin have been widely used in.
First commercial artificial skin is people's inventions such as Yannas in the world.1977, Yannas disclosed a kind of double-layered artificial skin of non-activity cell in patent US 4060081.Lower floor is cross-linked to form the support with certain hole by type i collagen albumen (tendon) and the aminopolysaccharide (chondroitin sulfate) of extraction cattle, its aperture is 30-120 um, porosity is up to 98%, can allow histiocyte, macrophage, lymph corpuscle and blood tubule to generate, do not have immunological rejection between this layer and the human body, can in body fluid, not dissolve and degrade; The upper strata is comprised of nontoxic silicon rubber film, can resist the intrusion of extraneous antibacterial, and the evaporation of control wound aqueous vapor makes the moisture-vapor transmission of whole artificial skin be controlled at 0.1 ~ 1 mg/cm
2/ hr.But this artificial skin also existent defect when clinical use: can not life-time service, mechanical strength is relatively poor, the silicone rubber on upper strata will be removed easy infection and additionally increased patient's misery in the treatment later stage; The upper strata silicon rubber film is dense film, and breathability does not reach the level of real skin.
2009, the double-layered artificial skin of a kind of Biobrane of being similar to has been described among people's patent US 2009/0232878 A1 such as Woodroof.Bottom is the knitting nylon net with even distribution hole; The upper strata is that thickness is the silicone rubber perforated membrane of 25 um, and the aperture is about 0.75 ~ 1.05 mm, and its hole is that the method by vacuum drawn makes.Its aperture and porosity be large than Biobrane artificial skin all, can give good protection to cutaneous lesion.Yet this artificial skin is the same with Biorane, can not be used for the deep third degree damage, and can not forever use.The aperture of silicon rubber film is too large, can not resist extraneous antibacterial fully and invade the effect that does not also have waterproof.
Prepare the suitable and regulatable porous silicon rubber film in a kind of aperture and seem particularly important.
The method for preparing at present porous polymer material mainly contains: phase separation method, nuclear track method, filler crush method, pulling method, porogen leach method and freeze-drying etc.Wherein to leach method technique simple and be widely used for porogen.Used porogen can be that solid also can be liquid.
The people such as Jess Paul Fuller disclose a kind of preparation method of the porous silicon rubber for cell and tissue growth in patent US 6,900,055 B1.With silicone rubber predecessor and porogen mechanical mixture, then solidify first, remove at last the various silastic products that porogen has just obtained having loose structure.Wherein porogen is the inorganic metal salt through grinding, such as metal halide, metal carbonate or alkali metal bicarbonate salt etc.Selected silicone rubber is take cold curing as best, to prevent the decomposition of porogen under hot conditions.Also can add some other fillers in the silicone rubber simultaneously, make goods have electric conductivity such as metal dust or white carbon black.
Have following shortcoming with solid as porogen: the particle diameter of solid porogen is difficult for reaching nanoscale, and the more long-pending more large easier reunion of small specific surface of particle diameter, and difficult preparation has the porous silicon rubber of small-bore.On the other hand, the viscosity of film forming liquid is wanted suitably in preparation silicon rubber thin membrane process, and more film forming of solid porogen adding fluid viscosity is certain to larger, is difficult for the high silicone rubber membrane of preparation thin thickness porosity.
When making porogen with liquid, by simple mechanical type mixing porogen is dispersed in the matrix, need in system, adds emulsifying agent or surfactant, be unlikely to phase-splitting.Yet the 3rd component that in most cases adds is difficult for removing and some has toxicity to organism.
The people such as Fabrice Axisa have described a kind of method for preparing porous elastomers at U.S. Pat. No.2010/0075056 A1, and the problem above successfully having solved can be used for the preparation of medical grade silicon rubber and elastic polyurethane porous body material.Liquid silastic presoma and firming agent and porogen water, glycerol or Mel high-speed stirred under vacuum condition are prepared into homodisperse emulsion, then pass through the method film forming of spin-coating film or blade coating film forming, remove porogen after silicone rubber solidifies, obtaining the aperture is the porous silicon rubber film that 2 ~ 5 um have intercommunicating pore.Yet this preparation technology is comparatively complicated, and the too high generation heat effect of speed of agitator can make silicone rubber solidify in advance, is difficult for being processed into the porous silicon rubber of respective shapes after the curing.Porous silicon rubber film aperture with the method preparation is too large, will not have the effect of resisting extraneous bacterial invasion, the wound easy infection if be used for artificial skin.
Summary of the invention
Can not effectively resist too greatly the problems such as extraneous bacterial invasion for the existing aperture that is used for artificial skin, the invention provides a kind of porous silicon rubber film for artificial skin.The present invention is little for the porous silicon rubber film aperture of artificial skin, can effectively resist the invasion of extraneous antibacterial, and it is simple that its preparation method has technique, and energy consumption is low, and cost is low, and film thickness holds manageable advantage.
A kind of porous silicon rubber film for artificial skin, the initiation material of this porous membrane is composed of the following components, counts by weight:
20 ~ 40 parts of silicone rubber predecessors,
35 ~ 80 parts of solvents,
0.5 ~ 40 part of non-solvent or porogen.
Described silicone rubber predecessor is the medical grade add-on type liquid silicon rubber, and described solvent is the effumability solvent, the difficult volatilization of described non-solvent or porogen.Add-on type liquid silicon rubber is to contain the vinyl polysiloxane to make base polymer, and the polysiloxane that contains the Si-H key is made cross-linking agent, under the platinum catalyst effect, and crosslinking curing and getting.
Its preparation method comprises following processing step: with 35 ~ 80 parts of 20 ~ 40 parts of silicone rubber predecessors, non-solvent or 0.5 ~ 40 part of porogen and solvents, add in the blender with agitator and thermometer, at room temperature mechanical agitation or ultra-sonic dispersion obtain film forming liquid; Adopt solvent evaporates to induce the phase separation method film forming, make the porous silicon rubber film of in the micro-or nano size scope, regulating in the aperture.
Described porous silicon rubber film, its preparation method comprise following concrete technology step:
1) with 20 ~ 40 parts of silicone rubber predecessor, 0.5 ~ 40 part of non-solvent or porogen, 35 ~ 80 parts of solvents add in the blender with agitator and thermometer, at room temperature mechanical agitation 10 ~ 20 min or disperse 5 ~ 10 min at ultrasonic 200 ~ 300 W obtain film forming liquid;
2) be 0.6 ~ 0.8 MPa deaeration, 20 ~ 50 min with above-mentioned film forming liquid standing and defoaming 3 ~ 6 h or vacuum;
3) with the film forming liquid after the above-mentioned deaeration spin coating or blade coating film forming on template, liquid embryophoric membrane thickness is 100 ~ 1000 um, or in mould casting film-forming, the thickness of liquid embryophoric membrane is 1 ~ 2 mm;
4) step 3) is scribbled the template of liquid embryophoric membrane or the mould of liquid embryophoric membrane is housed, 25 ~ 60 ° of C place 2 ~ 60 min in temperature, and the solvent evaporates in the liquid embryophoric membrane is removed;
5) the silicone rubber predecessor embryophoric membrane that contains non-solvent or porogen with the step 4) desolventizing solidifies 10 ~ 30 min molding at 100 ~ 150 ° of C of temperature, obtains silicon rubber film;
6) silicon rubber film that step 5) is obtained is at 40 ~ 70 ° of C of temperature, removed non-solvent or porogen in 3 ~ 4 days through solvent soaking or extracting, soak or extractive process in every day change solvent one time, take out again silicon rubber film, obtain the porous silicon rubber film of in the micro-or nano size scope, regulating in the aperture after the oven dry.
Described solvent is at least a in normal hexane, normal heptane, pentane, normal octane, positive nonane, toluene or the dimethylbenzene.
Described non-solvent or porogen are at least a in vaseline, liquid paraffin, alkylphenol polyoxyethylene (OP-10), Triton X-100 (emulsifying agent TX-10), sorbitan fatty acid ester (Span), polyoxyethylene sorbitan carboxylic ester (Tween), cetyl trimethyl ammonium bromide (CTAB), polyvinylpyrrolidone (PVP), glyceryl monostearate, starch, sodium citrate, lecithin, chitin, sodium chloride or the calcium carbonate.
Described non-solvent or porogen are at least a in vaseline, liquid paraffin, Span-20 (Span-20), Tween-40 (Tween-40), lecithin, cetyl trimethyl ammonium bromide (CTAB), sodium citrate or the glyceryl monostearate.
The material of described template or mould is any in glass, politef or the polyester.
Described medical add-on type liquid silicon rubber can be at 100 ~ 150 ° of C curing moldings of temperature.
Described porous silicon rubber film surface hole defect Uniform Dispersion, its average pore size are 500 nm ~ 140 μ m.
The present invention has following advantage:
1) the present invention adopts solvent evaporates to induce the film forming that is separated, and non-solvent or porogen leach the method pore-forming, the porous silicon rubber film even aperture distribution that obtains and adjustable.
2) preparation technology of porous silicon rubber film of the present invention is simple, and energy consumption is low, and film thickness is controlled easily.
3) do not produce waste gas and waste liquid in the preparation process of porous silicon rubber film of the present invention, environmentally friendly.
4) average pore size of porous silicon rubber film surface hole defect of the present invention is 500 nm ~ 140 μ m, and the aperture is little, is used for the invasion that artificial skin can be resisted extraneous antibacterial, and wound is easy infection not.
Description of drawings
Fig. 1 is the porous silicon rubber film electron scanning micrograph of embodiment 1 preparation;
Fig. 2 is the porous silicon rubber film optical electron microscope photo of embodiment 2 preparations;
Fig. 3 is the porous silicon rubber film electron scanning micrograph of embodiment 3 preparations;
Fig. 4 is the porous silicon rubber film optical electron microscope photo of embodiment 4 preparations;
Fig. 5 is the porous silicon rubber film electron scanning micrograph of embodiment 5 preparations;
Fig. 6 is the porous silicon rubber film electron scanning micrograph of embodiment 6 preparations;
Fig. 7 is the porous silicon rubber film electron scanning micrograph of embodiment 7 preparations;
Fig. 8 is the porous silicon rubber film optical electron microscope photo of embodiment 8 preparations.
The specific embodiment
Medical grade add-on type liquid silicon rubber used in following examples is commercially available, such as DOW CORNING SILASTIC Q7-4840 BioMedical Grade Liquid Silicone Rubber Parts A and B, or the medical grade add-on type liquid silicon rubber of Shenzhen Kai Wote organosilicon material company limited production, other reagent is also all bought from the market.
Embodiment 1
25 g medical grade add-on type liquid silicon rubbers, 5 g liquid paraffin and 2 g Span-80 are added in the 68 g normal hexane, stir 20 min under the room temperature and obtain film forming liquid, standing and defoaming 3 h.With coating device film forming liquid is coated on the polyfluortetraethylene plate, thickness is 800 um, and is placed on 40 min in 25 ° of C environment, and solvent evaporates causes being separated.Then polyfluortetraethylene plate is put into 100 ° of C baking ovens, the silicone rubber predecessor solidifies 20 min molding.The silicon rubber film that contains liquid paraffin and Span-80 after solidifying is immersed in 65 ° of C normal hexane 3 days, changes solvent every day one time.Take out silicon rubber film after 3 days, be immersed in successively in ethanol and the deionized water, obtain the porous silicon rubber film after the oven dry.The porous silicon rubber film surface texture that makes as shown in Figure 1, silicon rubber film surface hole defect Uniform Dispersion, the aperture is about 500 nm.
20 g medical grade add-on type liquid silicon rubbers, 2 g Span-20 are added in the 78 g pentanes, and ultrasonic 200 W disperse 5 min to obtain film forming liquid under the room temperature, standing and defoaming 6 h.Get 4 g film forming liquid and be spun on the glass plate, rotating speed 600 rpm, thickness is 100 um, and is placed on 2 min in 60 ° of C environment, solvent evaporates causes being separated.Then the glass plate plate is put into 120 ° of C baking ovens, the silicone rubber predecessor solidifies 15 min molding.The silicon rubber film that contains Span-20 after solidifying is immersed in 40 ° of C pentanes 4 days, changes solvent every day one time.Take out silicon rubber film after 4 days, be immersed in successively in ethanol and the deionized water, obtain the porous silicon rubber film after the oven dry.The porous silicon rubber film surface texture that makes as shown in Figure 2, the aperture is about 800 nm.
Embodiment 3
25 g medical grade add-on type liquid silicon rubbers, 0.5 g Tween-40 are added in the 80 g normal heptane, stir 10 min under the room temperature and obtain film forming liquid, vacuum is 0.6 MPa deaeration, 20 min.Film at polyester sheet with coating device, thickness is 500 um, and is placed on 30 min in 25 ° of C environment, and solvent evaporates causes being separated.Then polyester sheet is put into 100 ° of C baking ovens, the silicone rubber predecessor solidifies 20 min molding.The silicon rubber film that contains Tween-40 after solidifying is immersed in 65 ° of C normal heptane 4 days, changes solvent every day one time.Take out silicon rubber film after 4 days, be immersed in successively in ethanol and the deionized water, obtain the porous silicon rubber film after the oven dry.The porous silicon rubber film surface texture that makes as shown in Figure 3, silicon rubber film surface hole defect Uniform Dispersion, the aperture is about 1 um.
Embodiment 4
30 g medical grade add-on type liquid silicon rubbers, 5 g vaseline are added in the 60 g normal octanes, and ultrasonic 300 W disperse 10 min to obtain film forming liquid under the room temperature, and vacuum is 0.8 MPa deaeration, 20 min.Film at polyfluortetraethylene plate with coating device, thickness is 500 um, and is placed on 10 min in 60 ° of C environment, and solvent evaporates causes being separated.Then polyfluortetraethylene plate is put into 150 ° of C baking ovens, the silicone rubber predecessor solidifies 10 min molding.The silicon rubber film that contains vaseline after solidifying is immersed in 70 ° of C normal octanes 3 days, changes solvent every day one time.Take out silicon rubber film after 3 days, be immersed in successively in ethanol and the deionized water, obtain the porous silicon rubber film after the oven dry.The porous silicon rubber film surface texture that makes as shown in Figure 4, the aperture is about 6 um.
Embodiment 5
40 g medical grade add-on type liquid silicon rubbers, 20 g liquid paraffin are added in the 40 g toluene, stir 20 min under the room temperature and obtain film forming liquid, leave standstill 5 h deaerations.Film at polyester sheet with coating device, thickness is 800 um, and is placed on 20 min in 60 ° of C environment, and solvent evaporates causes being separated.Then polyester sheet is put into 100 ° of C baking ovens, the silicone rubber predecessor solidifies 20 min molding.The silicon rubber film that contains liquid paraffin after solidifying is immersed in 60 ° of C toluene 4 days, changes solvent every day one time.Take out silicon rubber film after 4 days, be immersed in successively in ethanol and the deionized water, obtain the porous silicon rubber film after the oven dry.The porous silicon rubber film surface texture that makes as shown in Figure 5, the aperture is about 20 um.
Embodiment 6
25 g medical grade add-on type liquid silicon rubbers, 40 g liquid paraffin are added in the 35 g normal hexane, and ultrasonic 250 W disperse 8 min to obtain film forming liquid under the room temperature, leave standstill 4 h deaerations.Film at polyfluortetraethylene plate with coating device, thickness is 800 um, and is placed on 30 min in 25 ° of C environment, and solvent evaporates causes being separated.Then polyfluortetraethylene plate is put into 150 ° of C baking ovens, the silicone rubber predecessor solidifies 10 min molding.With the extracting 4 days in 50 ° of C normal hexane of the silicon rubber film that contains liquid paraffin after solidifying.Take out silicon rubber film after 4 days, be immersed in successively in ethanol and the deionized water, obtain the porous silicon rubber film after the oven dry.The porous silicon rubber film surface texture that makes as shown in Figure 6, the aperture is about 25 um.
Embodiment 7
25 g medical grade add-on type liquid silicon rubbers, 20 g liquid paraffin are added in the 55 g normal hexane, stir 20 min under the room temperature and obtain film forming liquid, leave standstill 3 h deaerations.Pour solution in politef mould casting film-forming, thickness is 1200 um, and is placed on 60 min in 25 ° of C environment, and solvent evaporates causes being separated.Then the politef mould is put into 130 ° of C baking ovens, the silicone rubber predecessor solidifies 30 min molding.With extracting in the 70 ° of C normal hexane of the silicon rubber film that contains liquid paraffin after solidifying 3 days.Take out silicon rubber film after 3 days, be immersed in successively in ethanol and the deionized water, obtain the porous silicon rubber film after the oven dry.The porous silicon rubber film surface texture that makes as shown in Figure 7, the aperture is about 140 um.
Embodiment 8
25 g medical grade add-on type liquid silicon rubbers, 2 g lecithin are added in the 73 g normal hexane, and ultrasonic 300 W disperse 10 min to obtain film forming liquid under the room temperature, and vacuum is 0.7 MPa deaeration, 40 min.Film at polyfluortetraethylene plate with coating device, thickness is 600 um, and is placed on 40 min in 25 ° of C environment, and solvent evaporates causes being separated.Then polyfluortetraethylene plate is put into 130 ° of C baking ovens, the silicone rubber predecessor solidifies 20 min molding.The silicon rubber film that contains lecithin after solidifying is immersed in 65 ° of C normal hexane 4 days, changes solvent every day one time.Take out silicon rubber film after 4 days, be immersed in successively in ethanol and the deionized water, obtain the porous silicon rubber film after the oven dry.The porous silicon rubber film surface texture that makes as shown in Figure 8, the aperture is about 800 nm.
Embodiment 9
25 g medical grade add-on type liquid silicon rubbers, 1.5 g cetyl trimethyl ammonium bromide (CTAB) are added in the 60 g normal hexane, stir 10 min under the room temperature and obtain film forming liquid, leave standstill 3 h deaerations.Film at polyfluortetraethylene plate with coating device, thickness is 700 um, and is placed on 30 min in 25 ° of C environment, and solvent evaporates causes being separated.Then polyfluortetraethylene plate is put into 100 ° of C baking ovens, the silicone rubber predecessor solidifies 20 min molding.The silicon rubber film that contains cetyl trimethyl ammonium bromide (CTAB) after solidifying is immersed in 65 ° of C normal hexane 4 days, changes solvent every day one time.Take out silicon rubber film after 4 days, be immersed in successively in ethanol and the deionized water, obtain the porous silicon rubber film after the oven dry.
Embodiment 10
30 g medical grade add-on type liquid silicon rubbers, 2 g glyceryl monostearate are added in the 80 g normal hexane, stir 15 min under the room temperature and obtain film forming liquid, leave standstill the 4h deaeration.Pour solution in politef mould casting film-forming, thickness is 1 mm, and is placed on 10 min in 60 ° of C environment, and solvent evaporates causes being separated.Then the politef mould is put into 100 ° of C baking ovens, the silicone rubber predecessor solidifies 20 min molding.The silicon rubber film that contains glyceryl monostearate after solidifying is immersed in 55 ° of C normal hexane 4 days, changes solvent every day one time.Take out silicon rubber film after 4 days, be immersed in successively in ethanol and the deionized water, obtain the porous silicon rubber film after the oven dry.
Embodiment 11
30 g medical grade add-on type liquid silicon rubbers, 10 g sodium citrate powder are added in the 60 g normal hexane, and ultrasonic 300 W disperse 10 min film forming liquid under the room temperature, and vacuum is 0.8 MPa deaeration, 50 min.Pour gained solution in politef mould casting film-forming, thickness is 2 mm, and is placed on 60 min in 30 ° of C environment, and solvent evaporates causes being separated.Then the politef mould is put into 130 ° of C baking ovens, the silicone rubber predecessor solidifies 20 min molding.The silicon rubber film that contains sodium citrate after solidifying is immersed in 40 ° of C water 4 days, changes solvent every day one time.Take out silicon rubber film after 4 days, obtain the porous silicon rubber film after the oven dry.
Claims (8)
1. porous silicon rubber film that is used for artificial skin is characterized in that the initiation material of this porous membrane is composed of the following components, counts by weight:
20 ~ 40 parts of silicone rubber predecessors,
35 ~ 80 parts of solvents,
0.5 ~ 40 part of non-solvent or porogen,
Described silicone rubber predecessor is the medical grade add-on type liquid silicon rubber, and described solvent is the effumability solvent, the difficult volatilization of described non-solvent or porogen;
Its preparation method comprises following processing step: with 35 ~ 80 parts of 20 ~ 40 parts of silicone rubber predecessors, non-solvent or 0.5 ~ 40 part of porogen and solvents, in the blender of adding with agitator and thermometer, at room temperature mechanical agitation or ultra-sonic dispersion obtain film forming liquid; Adopt solvent evaporates to induce the phase separation method film forming, make the porous silicon rubber film of in the micro-or nano size scope, regulating in the aperture.
2. porous silicon rubber film according to claim 1 is characterized in that, its preparation method comprises following concrete technology step:
1) with in 20 ~ 40 parts of silicone rubber predecessors, non-solvent or 0.5 ~ 40 part of porogen and the blender of 35 ~ 80 parts of addings of solvent with agitator and thermometer, at room temperature mechanical agitation 10 ~ 20 min or disperse 5 ~ 10 min at ultrasonic 200 ~ 300 W obtain film forming liquid;
2) be 0.6 ~ 0.8 MPa deaeration, 20 ~ 50 min with above-mentioned film forming liquid standing and defoaming 3 ~ 6 h or vacuum;
3) with the film forming liquid after the above-mentioned deaeration spin coating or blade coating film forming on template, liquid embryophoric membrane thickness is 100 ~ 1000 um, or in mould casting film-forming, the thickness of liquid embryophoric membrane is 1 ~ 2 mm;
4) step 3) is scribbled the template of liquid embryophoric membrane or the mould of liquid embryophoric membrane is housed, 25 ~ 60 ° of C place 2 ~ 60 min in temperature, and the solvent evaporates in the liquid embryophoric membrane is removed;
5) the silicone rubber predecessor embryophoric membrane that contains non-solvent or porogen with the step 4) desolventizing solidifies 10 ~ 30 min molding at 100 ~ 150 ° of C of temperature, obtains silicon rubber film;
6) silicon rubber film that step 5) is obtained is at 40 ~ 70 ° of C of temperature, removed non-solvent or porogen in 3 ~ 4 days through solvent soaking or extracting, soak or extractive process in every day change solvent one time, take out again silicon rubber film, obtain the porous silicon rubber film of in the micro-or nano size scope, regulating in the aperture after the oven dry.
3. porous silicon rubber film according to claim 1 and 2 is characterized in that, described solvent is any in normal hexane, normal heptane, pentane, normal octane, positive nonane, toluene or the dimethylbenzene.
4. porous silicon rubber film according to claim 1 and 2, it is characterized in that described non-solvent or porogen are at least a in vaseline, liquid paraffin, alkylphenol polyoxyethylene (OP-10), Triton X-100 (emulsifying agent TX-10), sorbitan fatty acid ester (Span), polyoxyethylene sorbitan carboxylic ester (Tween), cetyl trimethyl ammonium bromide (CTAB), polyvinylpyrrolidone (PVP), glyceryl monostearate, starch, sodium citrate, lecithin, chitin, sodium chloride or the calcium carbonate.
5. porous silicon rubber film according to claim 4, it is characterized in that described non-solvent or porogen are at least a in vaseline, liquid paraffin, Span-20, Tween-40, lecithin, cetyl trimethyl ammonium bromide (CTAB), sodium citrate or the glyceryl monostearate.
6. preparation method according to claim 2 is characterized in that, the material of described template or mould is any in glass, politef or the polyester.
7. porous silicon rubber film according to claim 1 and 2 is characterized in that, described medical add-on type liquid silicon rubber can be at 100 ~ 150 ° of C curing moldings of temperature.
8. one of according to claim 1-7 described porous silicon rubber film is characterized in that, described porous silicon rubber film surface hole defect Uniform Dispersion, and its average pore size is 500 nm ~ 140 μ m.
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