CN102940832A - Medicament for treating chronic bronchitis and preparation method thereof - Google Patents
Medicament for treating chronic bronchitis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicament for treating chronic bronchitis, which is prepared from the following raw medicines in parts by weight: 12 parts of prepared ephedra, 18 parts of gypsum, 12 parts of Chinese yam, 12 parts of hyacinth bletilla, 12 parts of prepared stemona root, 15 parts of prepared aster, 15 parts of prepared coltsfoot flower, 18 parts of hairyvein agrimony, 15 parts of fried burdock fruit, 15 parts of peucedanum root, 15 parts of swallowwort rhizome, 15 parts of prepared almond, 18 parts of balloon flower, 12 parts of dried orange peel, 18 parts of ophiopogon root, 18 parts of prepared lily, 15 parts of Chinese white olive, 15 parts of radix glehniae, 15 parts of prepared mulberry bark, 18 parts of fructus trichosanthis, 15 parts of mint, 15 parts of bulbus fritillariae cirrhosae, 15 parts of thunberg fritillary bulb, 18 parts of fried jujube kernel, 15 parts of blackberrylily rhizome, 15 parts of prepared schisandra, 15 parts of mulberry leaf and 6 parts of licorice. The traditional Chinese medicine preparation disclosed by the invention is mainly used for treating chronic bronchitis by oral administration; when administered orally, the liquid medicine is preferably heated to 37 DEG C; one dose of the medicament needs to be taken per day at twice, and one course of treatment lasts for 10 days; and an obvious curative effect can be obtained generally after 1-3 courses of treatment.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of chronic bronchitis and preparation method thereof.
Background technology
Chronic bronchitis is the chronic nonspecific inflammation of the trachea, bronchial mucosa and the surrounding tissue thereof that are caused by many factors, and clinical manifestation is repeatedly outbreak cough, expectoration or with panting; Be more common in old and middle-aged patients more than 40 years old, sickness rate increased with the age, and can progressively develop into obstructive emphysema, chronic pulmonary heart disease, had a strong impact on life in patients even caused death.Modern medicine thinks that the cause of disease of chronic bronchitis mainly is: 1, chemical factors makes the bronchus structure break ring, dysfunction, resistance such as smoking and descends and cause a disease; Chemical toxicant, dust and irritating smog etc. also can impel morbidity.2, intrinsic factor lowly reach autonomic nervous dysfunction and easily infected such as Pulmonary Defense Mechanism.3, infective agent, respiratory tract antibacterial or viral infection are the key factors that primary disease occurs and aggravates.4, irritated factor, the chronic bronchitis type of particularly panting is relevant with the irritated allergy that causes.
The categories such as " cough ", " phlegm retention " of the chronic bronchitis ownership traditional Chinese medical science, " the syndrome of dyspnea ".The traditional Chinese medical science thinks that the generation of primary disease and development have inside and outside two large factors, and exopathogenic factor is relevant with the invasion and attack of six climate exopathogens exopathogen, and endogenous cause of ill is not normal relevant with functions such as lung, spleen, kidneys then.Clinical syndrome differentiation can be divided into drink type, type of phlegm-heat stagnating in the lung, YIN-deficiency type of the lung and kidney, deficiency of both lung and spleen type, essential resistance of turbid phlegm type, Qi deficiency blood stasis type and deficiency type of QI of the lung and kidney in the exogenous cold.
At present, the treatment acute episode of chronic bronchitis phase is generally take infection, relieving cough and asthma, antiinflammatory as main method, but exist many shortcoming: at first, with regard to infection, infection is the major reason that causes acute episode of chronic bronchitis, but exists clinically the problems such as nosetiology is difficult to determine, pathogen drug resistance, allergy; Secondly, medicine for the treatment of cough and asthma exists again the possibility that causes disease to increase the weight of for for the patient of cardiovascular disease, and has the glucocorticoid of good antiinflammatory action, and its whole body ill effect has caused medical personnel's concern.The medicine of the treatment chronic bronchitis that therefore, research and development a kind ofly have no side effect, therapeutic effect is good is problem demanding prompt solution.
Summary of the invention
For above-mentioned prior art, the invention provides a kind ofly have no side effect, the medicine for the treatment of chronic bronchitis that therapeutic effect is good, and provide its preparation method.
The present invention is achieved by the following technical solutions:
A kind of medicine for the treatment of chronic bronchitis is to be made by the crude drug that comprises following weight portion: 9～12 parts in Herba Ephedrae processed, 15～18 parts in Gypsum Fibrosum, 9～12 parts of Rhizoma Dioscoreaes, 9～12 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 9～12 parts of Radix Stemonae, 12～15 parts of Radix Asteriss processed, 12～15 parts of Flos Farfaraees processed, 15～18 parts of Herba Agrimoniaes, 12～15 parts of Fructus Arctii (parched), 12～15 parts of Radix Peucedanis, 12～15 parts of Rhizoma Cynanchi Stauntoniis, 12～15 parts in Semen Armeniacae Amarum processed, 15～18 parts of Radix Platycodoniss, 9～12 parts of Pericarpium Citri Reticulataes, 15～18 parts of Radix Ophiopogonis, 15～18 parts of Bulbus Liliies processed, 12～15 parts of Fructus Canariis, 12～15 parts of Radix Glehniaes, 12～15 parts of Cortex Mori processed, 15～18 parts of Fructus Trichosanthis, 12～15 parts of Herba Menthaes, 12～15 parts of Bulbus Fritillariae Cirrhosaes, 12～15 parts of Bulbus Fritillariae Thunbergiis, 15～18 parts of Semen Ziziphi Spinosae (parched)s, 12～15 parts of Rhizoma Belamcandae, 12～15 parts of Fructus Schisandrae (processed), 12～15 parts on Folium Mori, 6～9 parts in Radix Glycyrrhizae.
Preferably, be to be made by the crude drug of following weight portion: 12 parts in Herba Ephedrae processed, 18 parts in Gypsum Fibrosum, 12 parts of Rhizoma Dioscoreaes, 12 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 12 parts of Radix Stemonae, 15 parts of Radix Asteriss processed, 15 parts of Flos Farfaraees processed, 18 parts of Herba Agrimoniaes, 15 parts of Fructus Arctii (parched), 15 parts of Radix Peucedanis, 15 parts of Rhizoma Cynanchi Stauntoniis, 15 parts in Semen Armeniacae Amarum processed, 18 parts of Radix Platycodoniss, 12 parts of Pericarpium Citri Reticulataes, 18 parts of Radix Ophiopogonis, 18 parts of Bulbus Liliies processed, 15 parts of Fructus Canariis, 15 parts of Radix Glehniaes, 15 parts of Cortex Mori processed, 18 parts of Fructus Trichosanthis, 15 parts of Herba Menthaes, 15 parts of Bulbus Fritillariae Cirrhosaes, 15 parts of Bulbus Fritillariae Thunbergiis, 18 parts of Semen Ziziphi Spinosae (parched)s, 15 parts of Rhizoma Belamcandae, 15 parts of Fructus Schisandrae (processed), 15 parts on Folium Mori, 6 parts in Radix Glycyrrhizae.
Further, also comprise the crude drug of following weight portion: 15～30 parts of Flos Loniceraes, 12～15 parts of Fructus Forsythiaes or/and 12～15 parts on rake leaf processed (if conditions of patients is relatively light, then these three kinds of crude drug can; If conditions of patients is comparatively serious, after then these three kinds of crude drug being added better clinical effectiveness is arranged).
Preferably, be to be made by the crude drug of following weight portion: 12 parts in Herba Ephedrae processed, 18 parts in Gypsum Fibrosum, 12 parts of Rhizoma Dioscoreaes, 12 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 12 parts of Radix Stemonae, 15 parts of Radix Asteriss processed, 15 parts of Flos Farfaraees processed, 15 parts of Flos Loniceraes, 18 parts of Herba Agrimoniaes, 15 parts of Fructus Arctii (parched), 15 parts of Radix Peucedanis, 15 parts of Rhizoma Cynanchi Stauntoniis, 15 parts in Semen Armeniacae Amarum processed, 18 parts of Radix Platycodoniss, 12 parts of Pericarpium Citri Reticulataes, 18 parts of Radix Ophiopogonis, 18 parts of Bulbus Liliies processed, 15 parts of Fructus Canariis, 12 parts of Fructus Forsythiaes, 15 parts of Radix Glehniaes, 15 parts of Cortex Mori processed, 12 parts on rake leaf processed, 18 parts of Fructus Trichosanthis, 15 parts of Herba Menthaes, 15 parts of Bulbus Fritillariae Cirrhosaes, 15 parts of Bulbus Fritillariae Thunbergiis, 18 parts of Semen Ziziphi Spinosae (parched)s, 15 parts of Rhizoma Belamcandae, 15 parts of Fructus Schisandrae (processed), 15 parts on Folium Mori, 6 parts in Radix Glycyrrhizae.
The preparation method of the medicine of described treatment chronic bronchitis is: get each crude drug, be immersed in the water together, be as the criterion with submergence, soak 30～90 minutes (preferred 30～60 minutes of summer, preferred 60～90 minutes of other season, override 60 minutes), then slow fire boiling is 20～30 minutes, filter and remove residue gets medicinal liquid, is the Chinese medicine preparation for the treatment of chronic bronchitis.
The property of medicine of the crude drug that the present invention is used is as follows:
Herba Ephedrae processed: feeble QI is fragrant, puckery, little hardship, temperature.Return lung, urinary bladder channel, nourishing the lung to arrest cough.
Gypsum Fibrosum: sweet in the mouth, suffering, Great Cold.Attach to the lung and stomach meridians, clearing away heat-fire, relieving restlessness is quenched the thirst.
Rhizoma Dioscoreae: sweet in the mouth is flat.Return spleen, lung, kidney channel, spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.
Pseudobulbus Bletillae (Rhizoma Bletillae): bitter in the mouth, sweet, puckery is slightly cold.Return lung, liver, stomach warp, astringing to arrest bleeding, detumescence and promoting granulation.
Radix Stemonae: it is sweet to distinguish the flavor of, and stickiness is slightly arranged, slightly focal spot.Return lung meridian, nourishing the lung to arrest cough.
Radix Asteris processed: sweet fragrance is arranged, and it is sweet to distinguish the flavor of.Return lung meridian, nourishing the lung to keep the adverse QI downward, stopping coughing and removing phlegm.
Flos Farfarae processed: acrid in the mouth, little hardship, temperature.Return lung meridian, nourishing the lung to keep the adverse QI downward, relieving cough and resolving phlegm.
Herba Agrimoniae: bitter in the mouth, puckery is flat.GUIXIN, Liver Channel, astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, detoxifcation, tonify deficiency.
Fructus Arctii (parched): acrid in the mouth, hardship, cold in nature, little have fragrance.Attach to the lung and stomach meridians dispelling wind and heat pathogens, lung qi dispersing rash, resolving toxin and disinhibiting the throat.
Radix Peucedani: bitter in the mouth, suffering are slightly cold.Return lung meridian, lowering the adverse-rising QI to resolve phlegm, loose wind heat clearing away.
Rhizoma Cynanchi Stauntonii: acrid in the mouth, hardship, tepor is returned lung meridian, sending down the abnormal ascending QI, expectorant, cough-relieving.
Semen Armeniacae Amarum processed: bitter in the mouth has special fragrance, tepor; Slightly poisonous.Return lung, large intestine channel, sending down the abnormal ascending QI relieving cough and asthma, loosening bowel to relieve constipation.
Radix Platycodonis: bitter in the mouth, suffering, flat, return lung meridian, open lung qi dispersing gas, the evacuation of pus of eliminating the phlegm.
Pericarpium Citri Reticulatae: bitter in the mouth, suffering, tepor.Return lung, spleen channel, regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.
Radix Ophiopogonis: sweet in the mouth, little hardship are slightly cold.GUIXIN, lung, stomach warp, YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.
Bulbus Lilii processed: sweet in the mouth, cold.GUIXIN, lung meridian, nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization.
Fructus Canarii: sweet in the mouth, acid, flat.Attach to the lung and stomach meridians, heat-clearing and toxic substances removing, sore-throat relieving promotes the production of body fluid.
Radix Glehniae: sweet in the mouth, little hardship are slightly cold.Attach to the lung and stomach meridians nourishing YIN and clearing away lung-heat, reinforcing stomach reg fluid.
Cortex Mori processed: sweet in the mouth, cold.Return lung meridian, eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.
Flos Lonicerae: sweet in the mouth, cold.Return lung, the heart, stomach warp, heat-clearing and toxic substances removing, dispelling wind and heat pathogens.
Fructus Trichosanthis: sweet in the mouth, little hardship, cold.Return lung, stomach, large intestine channel, clearing away heat and eliminating phlegm, is moisturized laxation at relieving stuffiness of the chest by dispersing aggregation of pathogens.
Herba Menthae: acrid in the mouth, cold.Return lung, Liver Channel, dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving, rash, soothing the liver circulation of qi promoting.
Bulbus Fritillariae Cirrhosae: bitter in the mouth, sweet is slightly cold.Return lung, heart channel, clearing heat and moistening lung, preventing phlegm from forming and stopping coughing, eliminating stagnation eliminating carbuncle.
Bulbus Fritillariae Thunbergii: bitter in the mouth, cold.Return lung, heart channel, clearing heat, eliminating phlegm, relieving cough, detoxicating and resolving stagnation of pathogens eliminating carbuncle.
Semen Ziziphi Spinosae (parched): slightly sweet flavor, slightly burnt odor gas, acid, flat.Return liver, gallbladder, heart channel, the tonifying liver that nourishes heart, mind tranquilizing and the heart calming, arresting sweating promotes the production of body fluid.
Fructus Forsythiae: bitter in the mouth is slightly cold.Return lung, the heart, small intestine meridian, heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens.
Rhizoma Belamcandae: bitter in the mouth, feeble QI suffering, cold.Return lung meridian, heat-clearing and toxic substances removing, expectorant, sore-throat relieving.
Fructus Schisandrae (processed): sweet in the mouth acid, temperature.Return lung, the heart, kidney channel, restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.
Rake leaf processed: bitter in the mouth, be slightly cold.Attach to the lung and stomach meridians clearing away lung-heat to relieve cough, stopping nausea and vomiting by lowering the adverse flow of QI.
Folium Mori sweet in the mouth, hardship, cold.Return lung, Liver Channel, dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving.
Radix Glycyrrhizae: sweet in the mouth is flat.GUIXIN, lung, spleen, stomach warp, invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
Chinese medicine preparation of the present invention, used 31 flavor Chinese medicines all can conveniently have been bought in pharmacy, and with low cost, preparation method is also simple, and the Chinese medicine preparation toxic and side effects of making is little, absorbs in digestive tract soon, absorb easily, short treating period, cure rate is high.Though flavour of a drug are many, prescription is rigorous, monarch, and compatibility is proper, and pathogenesis hits.The clinical bronchitis that is used for the treatment of reduces or has avoided the application of glucocorticoid, the toxicity that reduces to greatest extent or avoided producing in the therapeutic process.The hot temperature of Herba Ephedrae processed in the side, diffusing lung, relieving exterior syndrome and relievining asthma is let out clearly the heat of lung stomach to promote the production of body fluid at Gypsum Fibrosum hot sweet Great Cold, and two medicines match, can lung qi dispersing, again can heat clearing away, in the treatment of chronic bronchitis, play a major role, be monarch drug altogether; Chronic bronchitis is often shown effect because of being invaded by exogenous pathogen or is increased the weight of, so use Folium Mori, Radix Platycodonis, the Herba Menthae lung qi dispersing is with loose evil, in the course of disease a surname of lung to fall not normal be main pathogenesis, so select Radix Peucedani, Rhizoma Cynanchi Stauntonii, stir-baked SEMEN ARMENIACAE AMARUM, Folium Eriobotryae falls lung with relieving cough and asthma, expectorant is common pathological product, also be that chronic bronchitis is shown effect repeatedly, the prolonged key factor that does not heal, the Fang Zhongyong Cortex Mori, Fructus Trichosanthis, the Bulbus Fritillariae Thunbergii lung heat clearing is to reduce phlegm, so lung being a delicate viscus is with Radix Asteris processed, Flos Farfarae, the Radix Stemonae, Bulbus Fritillariae Cirrhosae, Bulbus Lilii, Radix Ophiopogonis, the Radix Glehniae yin nourishing is with lung moistening, upper 17 flavor medicine or a surnames, or fall, or clear, or profit, be ministerial drug altogether; Throat is the door of lung, reduces phlegm so add Rhizoma Belamcandae, Fructus Canarii, Fructus Arctii relieving sore-throat by clearing away heat, and chronic bronchitis can be handed over because of good and evil at Acute Exacerbation Period and strive, and so the poison of life in producing is with Flos Lonicerae, Fructus Forsythiae heat-clearing and toxic substances removing; With Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Agrimoniae promoting regeneration of the tissue and arresting bleeding, to help the reparation of air flue mucosa injury, sick for a long time lung qi easily consumes, so restrain lung qi with Fructus Schisandrae Chinensis, Semen Ziziphi Spinosae, based on Zang-Fu relationship, Fang Zhongjia transfers tonifying the lung spleen kidney, Pericarpium Citri Reticulatae spleen invigorating activating QI to eliminate phlegm with Rhizoma Dioscoreae, and upper 11 flavors are adjuvant drug altogether; Radix Glycyrrhizae can expelling phlegm for arresting cough, can relax the property of medicine again, for making medicine.
Take a broad view of full side, a surname for the functional disorder of lung is arranged, fall, have for the eliminating the phlegm, detoxify of pathological product, tonification for the healthy energy damage is arranged, moisten, have for the relevant conditioning medicine of internal organs.Suit the basic pathogenesis of chronic bronchitis, clinical with it, lung heat clearing and non-impairment of YANG, lung moistening and do not grow is greasyly eliminated the phlegm and is not given birth to dryly, astringes the lung and does not stay heresy.
Chinese medicine preparation of the present invention cures mainly chronic bronchitis, and is oral during treatment, when oral, preferably fluid temperature is heated to 37 ℃.Every day, potion was taken at twice, and 10 is a course for the treatment of.Can obtain significant curative effect general 1～3 course for the treatment of.
The specific embodiment
The present invention is further illustrated below in conjunction with embodiment.
A kind of medicine for the treatment of chronic bronchitis of embodiment 1 preparation
Prescription is: Herba Ephedrae 12 grams processed, Gypsum Fibrosum 18 grams, Rhizoma Dioscoreae 12 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 12 grams, Radix Stemonae 12 grams, Radix Asteris 15 grams processed, Flos Farfarae 15 grams processed, Herba Agrimoniae 18 grams, Fructus Arctii (parched) 15 grams, Radix Peucedani 15 grams, Rhizoma Cynanchi Stauntonii 15 grams, Semen Armeniacae Amarum 15 grams processed, Radix Platycodonis 18 grams, Pericarpium Citri Reticulatae 12 grams, restrain Radix Ophiopogonis 18, Bulbus Lilii 18 grams processed, Fructus Canarii 15 grams, Radix Glehniae 15 grams, Cortex Mori 15 grams processed, Fructus Trichosanthis 18 grams, Herba Menthae 15 grams, Bulbus Fritillariae Cirrhosae 15 grams, Bulbus Fritillariae Thunbergii 15 grams, Semen Ziziphi Spinosae (parched) 18 grams, Rhizoma Belamcandae 15 grams, Fructus Schisandrae (processed) 15 grams, Folium Mori 15 grams, Radix Glycyrrhizae 6 grams.(this is the consumption of potion).
Preparation method is: get each crude drug, immerse together in 1500 ml waters, soaked 60 minutes, then slow fire boiling is 30 minutes, and filter and remove residue gets about 500 milliliters of medicinal liquid, is the pharmaceutical preparation for the treatment of chronic bronchitis.
During treatment, oral, fluid temperature is heated to 37 ℃.Every day, potion was taken at twice, and each about 250 milliliters, 10 is a course for the treatment of.
A kind of pharmaceutical preparation for the treatment of chronic bronchitis of embodiment 2 preparations
Prescription is: Herba Ephedrae 9 grams processed, Gypsum Fibrosum 15 grams, Rhizoma Dioscoreae 12 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 12 grams, Radix Stemonae 12 grams, Radix Asteris 12 grams processed, Flos Farfarae 9 grams processed, Herba Agrimoniae 12 grams, Fructus Arctii (parched) 15 grams, Radix Peucedani 15 grams, Rhizoma Cynanchi Stauntonii 15 grams, Semen Armeniacae Amarum 15 grams processed, Radix Platycodonis 18 grams, Pericarpium Citri Reticulatae 12 grams, restrain Radix Ophiopogonis 9, Bulbus Lilii 15 grams processed, Fructus Canarii 12 grams, Radix Glehniae 15 grams, Cortex Mori 15 grams processed, Fructus Trichosanthis 15 grams, Herba Menthae 15 grams, Bulbus Fritillariae Cirrhosae 9 grams, Bulbus Fritillariae Thunbergii 15 grams, Semen Ziziphi Spinosae (parched) 15 grams, Rhizoma Belamcandae 15 grams, Fructus Schisandrae (processed) 12 grams, Folium Mori 12 grams, Radix Glycyrrhizae 3 grams.
Preparation method is: get each crude drug, immerse together in 1500 ml waters, soaked 30 minutes, then slow fire boiling is 30 minutes, and filter and remove residue gets about 500 milliliters of medicinal liquid, is the pharmaceutical preparation for the treatment of chronic bronchitis.
A kind of pharmaceutical preparation for the treatment of chronic bronchitis of embodiment 3 preparations
Prescription is: Herba Ephedrae 12 grams processed, Gypsum Fibrosum 18 grams, Rhizoma Dioscoreae 15 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 12 grams, Radix Stemonae 12 grams, Radix Asteris 15 grams processed, Flos Farfarae 15 grams processed, Flos Lonicerae 24 grams, Herba Agrimoniae 18 grams, Fructus Arctii (parched) 15 grams, Radix Peucedani 15 grams, Rhizoma Cynanchi Stauntonii 15 grams, Semen Armeniacae Amarum 15 grams processed, Radix Platycodonis 18 grams, Pericarpium Citri Reticulatae 12 grams, restrain Radix Ophiopogonis 18, Bulbus Lilii 18 grams processed, Fructus Canarii 15 grams, Radix Glehniae 15 grams, Cortex Mori 12 grams processed, Fructus Trichosanthis 18 grams, Herba Menthae 15 grams, Bulbus Fritillariae Cirrhosae 15 grams, Bulbus Fritillariae Thunbergii 15 grams, Semen Ziziphi Spinosae (parched) 18 grams, Rhizoma Belamcandae 15 grams, Fructus Schisandrae (processed) 15 grams, Folium Mori 15 grams, Radix Glycyrrhizae 9 grams.
Preparation method is: get each crude drug, immerse together in 1500 ml waters, soaked 90 minutes, then slow fire boiling is 30 minutes, and filter and remove residue gets about 500 milliliters of medicinal liquid, is the pharmaceutical preparation for the treatment of chronic bronchitis.
A kind of pharmaceutical preparation for the treatment of chronic bronchitis of embodiment 4 preparations
Prescription is: Herba Ephedrae 9 grams processed, Gypsum Fibrosum 18 grams, Rhizoma Dioscoreae 9 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 12 grams, Radix Stemonae 12 grams, Radix Asteris 15 grams processed, Flos Farfarae 15 grams processed, Herba Agrimoniae 18 grams, Fructus Forsythiae 15 grams, Fructus Arctii (parched) 15 grams, Radix Peucedani 15 grams, Rhizoma Cynanchi Stauntonii 15 grams, Semen Armeniacae Amarum 15 grams processed, Radix Platycodonis 18 grams, Pericarpium Citri Reticulatae 12 grams, restrain Radix Ophiopogonis 18, Bulbus Lilii 18 grams processed, Fructus Canarii 15 grams, Radix Glehniae 15 grams, Cortex Mori 15 grams processed, Fructus Trichosanthis 18 grams, Herba Menthae 15 grams, Bulbus Fritillariae Cirrhosae 15 grams, Bulbus Fritillariae Thunbergii 15 grams, Semen Ziziphi Spinosae (parched) 15 grams, Rhizoma Belamcandae 15 grams, Fructus Schisandrae (processed) 15 grams, Folium Mori 15 grams, rake leaf 12 grams processed, Radix Glycyrrhizae 9 grams.
Preparation method is: get each crude drug, immerse together in 1500 ml waters, soaked 60 minutes, then slow fire boiling is 30 minutes, and filter and remove residue gets about 500 milliliters of medicinal liquid, is the pharmaceutical preparation for the treatment of chronic bronchitis.
A kind of pharmaceutical preparation for the treatment of chronic bronchitis of embodiment 5 preparations
Prescription is: Herba Ephedrae 12 grams processed, Gypsum Fibrosum 18 grams, Rhizoma Dioscoreae 12 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 12 grams, Radix Stemonae 12 grams, Radix Asteris 15 grams processed, Flos Farfarae 15 grams processed, Flos Lonicerae 15 grams, Herba Agrimoniae 18 grams, Fructus Arctii (parched) 15 grams, Radix Peucedani 15 grams, Rhizoma Cynanchi Stauntonii 15 grams, Semen Armeniacae Amarum 15 grams processed, Radix Platycodonis 18 grams, Pericarpium Citri Reticulatae 12 grams, restrain Radix Ophiopogonis 18, Bulbus Lilii 18 grams processed, Fructus Canarii 15 grams, Fructus Forsythiae 12 grams, Radix Glehniae 15 grams, Cortex Mori 15 grams processed, rake leaf 12 grams processed, Fructus Trichosanthis 18 grams, Herba Menthae 15 grams, Bulbus Fritillariae Cirrhosae 15 grams, Bulbus Fritillariae Thunbergii 15 grams, Semen Ziziphi Spinosae (parched) 18 grams, Rhizoma Belamcandae 15 grams, Fructus Schisandrae (processed) 15 grams, Folium Mori 15 grams, Radix Glycyrrhizae 6 grams.
Preparation method is: get each crude drug, immerse together in 1500 ml waters, soaked 60 minutes, then slow fire boiling is 30 minutes, and filter and remove residue gets about 500 milliliters of medicinal liquid, is the pharmaceutical preparation for the treatment of chronic bronchitis.
Clinical data:
Patient's data: 120 routine chronic bronchitis people, Sex distribution sees Table 1.
The range of age of the routine chronic bronchitis people of table 1120
| Sex | The man | The woman |
| The example number | 72 | 48 |
| Percentage ratio | 60.00% | 40.00% |
120 routine chronic bronchitis people, age distribution sees Table 2.
The range of age of the routine chronic bronchitis people of table 2120
| Age (year) | 30~40 | 41~50 | 50~60 | 60~70 |
| The example number | 25 | 31 | 31 | 33 |
| Percentage ratio | 20.83% | 25.83% | 25.83% | 27.50% |
Therapeutic modality: all patients all take the Chinese medicine preparation of embodiment 1 preparation, when taking, with fluid temperature be heated to 37 ℃ oral.Every day, potion was taken at twice, and each about 250 milliliters, 10 is a course for the treatment of.It is withdrawal after the produce effects.
The standard of curative effect evaluation: " disease of tcm Standardization of diagnosis and curative effect " and the national chronic bronchitis clinical efficacy evaluation criteria formulated with reference to State Administration of Traditional Chinese Medicine: 1. produce effects: cough, expectorant, breathe heavily, the cardinal symptom basic controlling such as scorching or greatly alleviate, stable disease is without the recidivist; 2. effective: as to cough, expectorant, asthma shape and attack times minimizing; 3. invalid: as to cough, expectorant, asthma shape and attack times be all without the changer.As shown in table 5.
Therapeutic outcome: therapeutic outcome is shown in table 3, table 4, table 5.
The routine chronic bronchitis people of table 3120 curative effect table
| Produce effects | Take a turn for the better | Invalid | |
| The example number | 107 | 11 | 2 |
| Percentage ratio | 89.17% | 917% | 1.66% |
Table 4120 chronic bronchitis people shows the course for the treatment of
| The treatment natural law | 5～10 days | 11～15 days | 16～20 days | 21～30 days |
| The example number | 27 | 43 | 36 | 14 |
| Percentage ratio | 22.50% | 35.83% | 30.00% | 11.67% |
Information slip before and after the routine chronic bronchitis human therapy of table 5120
Clinical practice:
Totally 120 examples from patient in year March in March, 2010 to 2012 have been observed in this research.Be divided into two groups, test group 60 examples wherein, matched group 60 examples.
3.1 Therapeutic Method: 120 routine patients are divided into test group 60 examples, matched group 60 examples.
3.2 therapeutic modality:
Test group: all patients all take the Chinese medicine preparation of embodiment 1 preparation, when taking, with fluid temperature be heated to 37 ℃ oral.Every day, potion was taken at twice, and each about 250 milliliters, being used in conjunction 10 days is a course for the treatment of.It is withdrawal after the healing.
Matched group: Chinese patent medicine GANMAO QINGRE KELI, the peaceful granule of lung, or add the Western medicine oral antibiotic 10 days were one to observe the course for the treatment of.
3.3 observational technique:
3.3.1 inclusion criteria: meet modern medicine " chronic bronchitis " diagnostic criteria, and meet the traditional Chinese medical science " cough, pulmonary distension " diagnosis, the patient of dialectical genus " yin asthenia generating intrinsic heat is hindered in the hot Tianjin of expectorant ".
3.3.2 collection of data: the patient is paid a return visit, understand change of illness state, patient's medication onset time is added up, make comparison, and with reference to the Evaluation of Synthetic Effect of Holistic standard patient's four diagnostic methods situation, symptom integral are added up, draw the comprehensive therapeutic effect conclusion, compare.
3.4 observation index:
3.4.1 average onset time relatively
3.4.2 total effective rate relatively
3.4.36 it cure rate relatively
3.4.4 untoward reaction
3.5 statistical procedures:
3.5.1 onset time: as shown in table 6.
Table 6
Through t check, P＜0.01, test group average onset time obviously shortens than matched group.
3.5.2 clinical efficacy: as shown in table 7.
Table 7
Through X
2Check, P＜0.01, test group total effective rate and obvious effective rate all obviously are better than matched group.
3.5.3 untoward reaction:
Test group is seen 3 routine laxativeness, does not give special handling, all recovers normal defecation after the drug withdrawal of recovering.
3.6 therapeutic outcome:
By the medication efficacy analysis to test group and matched group, we reach a conclusion, use Chinese medicine preparation treatment chronic bronchitis of the present invention, emphysema, cough due to yin deficiency, phlegm dyspnea uncomfortable in chest, the diseases such as constipation, onset is rapid, and effective percentage, obvious effective rate significantly be better than general Chinese patent medicine and western medicine, has demonstrated fully the curative effect advantage of the exquisite compatibility of Chinese medicine.
Case Chen, man, 72 years old.The recurrent cough coughed up phlegm 30 years, increased the weight of to examine on November 12nd, 2011 in 5 days.The patient is over 30 years, the recurrent cough, coughs up phlegm, and increase the weight of winter, and once Multiple Hospitalization treatment is diagnosed as chronic bronchitis on inspection, and long-term the interruption used antibiotic, glucocorticoid and relieving cough and resolving phlegm medicine.5 days causes are suffered from cold and are caused above-mentioned symptom and increase the weight of, and yellow sputum is coughed up in cough, and matter is thick, be difficult to bring up, and companion's xerostomia, polydipsia, indigestion and loss of appetite, it is not smooth to defecate.Red tongue, yellow and thin fur, few Tianjin, thready and rolling pulse is number slightly.Blood test is conventional: WBC11.0*10
9/ L, C-XF shows: bronchitis also infects.Tcm diagnosis: cough (hinder in the hot Tianjin of expectorant); Control with clearing away lung-heat to relieve cough and act as expectorant.Medicine by embodiment 1 is treated, and is oral during treatment, and fluid temperature is heated to 37 ℃.Every day, potion was taken at twice, and each about 250 milliliters, 10 is a course for the treatment of.Period in a medicine advises it to drink more water, and takes a good rest the product that fasting is raw and cold, pungent, greasy.After taking medicine 7 days, cough obviously alleviates, and the expectorant complexion changed is white, and amount of expectoration reduces.The check routine blood test is without unusually.
Claims (5)
1. a medicine for the treatment of chronic bronchitis is characterized in that: be to be made by the crude drug that comprises following weight portion: 9～12 parts in Herba Ephedrae processed, 15～18 parts in Gypsum Fibrosum, 9～12 parts of Rhizoma Dioscoreaes, 9～12 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 9～12 parts of Radix Stemonae, 12～15 parts of Radix Asteriss processed, 12～15 parts of Flos Farfaraees processed, 15～18 parts of Herba Agrimoniaes, 12～15 parts of Fructus Arctii (parched), 12～15 parts of Radix Peucedanis, 12～15 parts of Rhizoma Cynanchi Stauntoniis, 12～15 parts in Semen Armeniacae Amarum processed, 15～18 parts of Radix Platycodoniss, 9～12 parts of Pericarpium Citri Reticulataes, 15～18 parts of Radix Ophiopogonis, 15～18 parts of Bulbus Liliies processed, 12～15 parts of Fructus Canariis, 12～15 parts of Radix Glehniaes, 12～15 parts of Cortex Mori processed, 15～18 parts of Fructus Trichosanthis, 12～15 parts of Herba Menthaes, 12～15 parts of Bulbus Fritillariae Cirrhosaes, 12～15 parts of Bulbus Fritillariae Thunbergiis, 15～18 parts of Semen Ziziphi Spinosae (parched)s, 12～15 parts of Rhizoma Belamcandae, 12～15 parts of Fructus Schisandrae (processed), 12～15 parts on Folium Mori, 6～9 parts in Radix Glycyrrhizae.
2. a kind of medicine for the treatment of chronic bronchitis according to claim 1 is characterized in that: be to be made by the crude drug of following weight portion: 12 parts in Herba Ephedrae processed, 18 parts in Gypsum Fibrosum, 12 parts of Rhizoma Dioscoreaes, 12 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 12 parts of Radix Stemonae, 15 parts of Radix Asteriss processed, 15 parts of Flos Farfaraees processed, 18 parts of Herba Agrimoniaes, 15 parts of Fructus Arctii (parched), 15 parts of Radix Peucedanis, 15 parts of Rhizoma Cynanchi Stauntoniis, 15 parts in Semen Armeniacae Amarum processed, 18 parts of Radix Platycodoniss, 12 parts of Pericarpium Citri Reticulataes, 18 parts of Radix Ophiopogonis, 18 parts of Bulbus Liliies processed, 15 parts of Fructus Canariis, 15 parts of Radix Glehniaes, 15 parts of Cortex Mori processed, 18 parts of Fructus Trichosanthis, 15 parts of Herba Menthaes, 15 parts of Bulbus Fritillariae Cirrhosaes, 15 parts of Bulbus Fritillariae Thunbergiis, 18 parts of Semen Ziziphi Spinosae (parched)s, 15 parts of Rhizoma Belamcandae, 15 parts of Fructus Schisandrae (processed), 15 parts on Folium Mori, 6 parts in Radix Glycyrrhizae.
3. a kind of medicine for the treatment of chronic bronchitis according to claim 1 is characterized in that: the crude drug that also comprises following weight portion: 15～30 parts of Flos Loniceraes, 12～15 parts of Fructus Forsythiaes are or/and 12～15 parts on rake leaf processed.
4. a kind of medicine for the treatment of chronic bronchitis according to claim 3 is characterized in that: be to be made by the crude drug of following weight portion: 12 parts in Herba Ephedrae processed, 18 parts in Gypsum Fibrosum, 12 parts of Rhizoma Dioscoreaes, 12 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 12 parts of Radix Stemonae, 15 parts of Radix Asteriss processed, 15 parts of Flos Farfaraees processed, 15 parts of Flos Loniceraes, 18 parts of Herba Agrimoniaes, 15 parts of Fructus Arctii (parched), 15 parts of Radix Peucedanis, 15 parts of Rhizoma Cynanchi Stauntoniis, 15 parts in Semen Armeniacae Amarum processed, 18 parts of Radix Platycodoniss, 12 parts of Pericarpium Citri Reticulataes, 18 parts of Radix Ophiopogonis, 18 parts of Bulbus Liliies processed, 15 parts of Fructus Canariis, 12 parts of Fructus Forsythiaes, 15 parts of Radix Glehniaes, 15 parts of Cortex Mori processed, 12 parts on rake leaf processed, 18 parts of Fructus Trichosanthis, 15 parts of Herba Menthaes, 15 parts of Bulbus Fritillariae Cirrhosaes, 15 parts of Bulbus Fritillariae Thunbergiis, 18 parts of Semen Ziziphi Spinosae (parched)s, 15 parts of Rhizoma Belamcandae, 15 parts of Fructus Schisandrae (processed), 15 parts on Folium Mori, 6 parts in Radix Glycyrrhizae.
5. each described a kind of preparation method for the treatment of the medicine of chronic bronchitis in the claim 1～4, it is characterized in that: get each crude drug, be immersed in the water together, soaked 30～90 minutes, then slow fire boiling is 20～30 minutes, filter and remove residue gets medicinal liquid, is the Chinese medicine preparation for the treatment of chronic bronchitis.
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| CN103550666A (en) * | 2013-11-06 | 2014-02-05 | 咸温东 | Medicine for treating chronic bronchitis |
| CN103638300A (en) * | 2013-12-05 | 2014-03-19 | 青岛中科菲力工程技术研发有限公司 | Sauropus spatulifolius beille lung-clearing syrup and preparation method thereof |
| CN103933433A (en) * | 2014-03-22 | 2014-07-23 | 李双双 | Traditional Chinese medicine composition for treating chronic trachitis |
| CN104257757A (en) * | 2014-10-15 | 2015-01-07 | 程振顺 | Medicine for treating bronchitis |
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| CN103550666A (en) * | 2013-11-06 | 2014-02-05 | 咸温东 | Medicine for treating chronic bronchitis |
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| CN104306918A (en) * | 2014-09-28 | 2015-01-28 | 苏州市天灵中药饮片有限公司 | Plaster for treating chronic bronchitis and preparation method thereof |
| CN104257757A (en) * | 2014-10-15 | 2015-01-07 | 程振顺 | Medicine for treating bronchitis |
| CN104524304A (en) * | 2015-01-09 | 2015-04-22 | 王乃伟 | Traditional Chinese medicine composition for treating bronchial inflammation |
| CN105106789A (en) * | 2015-09-01 | 2015-12-02 | 江淑芬 | Traditional Chinese medicine composition for treating chronic bronchitis and preparation method thereof |
| CN105343720A (en) * | 2015-11-29 | 2016-02-24 | 韦富林 | Cortex lycii radicis composition medicine for treating bronchitis |
| CN105816778A (en) * | 2016-05-10 | 2016-08-03 | 刘建波 | Traditional Chinese medicine oral solution for treating chromic bronchitis |
| CN106075231A (en) * | 2016-07-14 | 2016-11-09 | 郑州五行舒体商贸有限公司 | Lv Yuan nurses one's health draft film |
| CN108186957A (en) * | 2018-02-26 | 2018-06-22 | 济南百鸣生物制药有限公司 | A kind of Chinese medicine composition for treating poultry multi-pathogenesis respiratory disease and preparation method thereof |
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| CN110801504A (en) * | 2019-10-22 | 2020-02-18 | 刘易宗 | A Chinese medicinal composition for treating pulmonary diseases |
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