CN102920612A - Broad-spectrum antibacterial cosmetic antiseptic and application thereof - Google Patents
Broad-spectrum antibacterial cosmetic antiseptic and application thereof Download PDFInfo
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- CN102920612A CN102920612A CN2012103124435A CN201210312443A CN102920612A CN 102920612 A CN102920612 A CN 102920612A CN 2012103124435 A CN2012103124435 A CN 2012103124435A CN 201210312443 A CN201210312443 A CN 201210312443A CN 102920612 A CN102920612 A CN 102920612A
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Abstract
The invention discloses a broad-spectrum antibacterial cosmetic antiseptic comprising the components of, by mass: 8-12% of caprylhydroxamic acid, 38-45% of phenethyl alcohol, and 46-54% of methylpropanediol. The antiseptic provided by the invention has the advantages that: (1) the antiseptic has broad-spectrum antibacterial activity, and can effectively inhibit Gram-negative and positive bacteria, yeasts and molds; (2) the antiseptic does not contain traditional antiseptic and bactericide, and is a cosmetic-use complex system completely satisfying a concept of no antiseptic addition; and the antiseptic has low irritation and high safety; and (3) the antiseptic has good compatibility with most of cosmetic raw materials; and the antibacterial capability of the antiseptic is not affected by surfactant, proteins and Chinese herbal medicine additives in cosmetics.
Description
Technical field
The invention belongs to the household chemicals field, be specifically related to a kind of broad-spectrum antiseptic cosmetics preservative and application thereof.
Background technology
Everybody has a love of beauty, and human just have continuous pursuit since ancient times to the cosmetics that beautify self.Cosmetics of a great variety, quality is also uneven.In order to improve the shelf-life of cosmetics, usually all can adopt antiseptic at present.Traditional preservatives mainly contains following several: (1) formaldehyde and formaldehyde releaser, shortcoming are to have potential carcinogenecity; (2) Bu Luobuer, shortcoming is easily to form Carcinogenic Nitrosamines; (3) organic halogen composition, shortcoming are potential sensitizations, (4) parabens, and shortcoming is potential estrogen and androgen and relevant with mastocarcinoma, the product of parabens is forbidden or limited the use of to European Union's suggestion original text.
Summary of the invention
Goal of the invention: in order to overcome the deficiencies in the prior art, the object of the present invention is to provide a kind of broad-spectrum antiseptic cosmetics preservative and application thereof that has antibacterial and the splendid inhibition of fungus.
Technical scheme: in order to solve the problems of the technologies described above, the technical solution adopted in the present invention is: a kind of broad-spectrum antiseptic cosmetics preservative (PrzvFree
TM1840) component that, comprises following mass percent: caprylhydroxamic acid (claiming again the N-hydroxyl positive caprylamide) 8-12%, phenethanol 38-45%, methyl propanediol 46-54%.
Wherein, caprylhydroxamic acid (CHA) adopts this content energy potent mould fungus inhibition---growth of Aspergillus niger (A.Niger), and antibacterial principle: CHA is to Fe
2+And Fe
3+The efficient selective chelation is arranged, in the iron ion constrained environment, the growth restriction of mycete; Ferrum is the key element of growth of microorganism, and Microbiological release chelating agen (siderophores) is caught Fe from environment
3+And it is converted into Fe
2+CHA chelating Fe
3+Stability constant high, can prevent that mycete (A.Niger) from obtaining ferrum element; And it is still effective when pH value is neutral, is antibacterial desirable organic acid; Also have the effect alive of short chain table: as ethohexadiol, it also has the best carbon chain lengths (C8) that can promote the membrane structure degraded.
Only so that dissociated state is not scattered in the organism, organic acid could be attacked mycete (A.Niger) as organic acid CHA.
CHA is unique organic acid that keeps unionized state in acidity to neutral whole process.
Phenethanol adopts this content energy anti-bacteria and saccharomycetic growth, and zest is little, is basic flavor of raw material.
Methyl propanediol is almost non-toxic, to skin and eyes nonirritant, is the wide solvent of safe handling scope.
The methyl propanediol fusing point is very low, can keep liquid condition under the low temperature very much, so can guarantee can keep flowability under the low temperature state by its composite product.Its high boiling point can reduce the loss of alcohol in the production process simultaneously, and its high-flash makes process safer.The branched structure of methyl propanediol is difficult for crystallization and makes product have good bin stability in course of reaction.
Adopt the content of said components and each component, caprylhydroxamic acid, phenethanol fully are dissolved in the methyl propanediol.
Described cosmetics preservative (PrzvFree
TM1840) application in the preparation cosmetics, described antiseptic (PrzvFree
TM1840) addition is to be 0.7～1.2%.
Described antiseptic (PrzvFree
TM1840) the pH value scope of application is 2～8.
Add described antiseptic (PrzvFree
TM1840) after, heating is no more than 2 hours in the time of 90 ℃, and heating is no more than 6 hours in the time of 60 ℃.
When described cosmetics are the cosmetics of surfactant system, add described antiseptic (PrzvFree below 60 ℃ in the cooling later stage
TM1840).
Antiseptic (PrzvFree of the present invention
TM1840) can be used for emulsification system, anhydrous formulations and surfactant washing system are such as cream frost, emulsion, bath oil, shampoo and color make-up etc.; Also can be used for opaque products.It can add water, can add under room temperature or high-temperature condition, does O/W emulsion, cream frost and also can add after system emulsifying.The pH value scope of application is: 2～8, neutral to the alkali condition with the increase of pH value, activity weakens gradually.The high temperature long-time operation is avoided in suggestion, causes the evaporation of phenethanol in case heat time heating time is long.Be no more than 2hr under 90 ℃, be no more than 6hr under 60 ℃.At surfactant systems such as shampoo, bath oils, can add below 60 ℃ in the cooling later stage.This product also can be used for the cleaning product of transparent surface activating agent system.
Use aborning deionized water, add an amount of chelating agen (such as EDTA-2Na), avoid running into copper ion and iron ion, to overcome contingent metachromatism as far as possible.
Antiseptic of the present invention opaque phenomenon (for normal physical phenomenon) may occur, a little transparent rear use of preheating when low temperature.
Beneficial effect: compared with prior art, advantage of the present invention is: 1) tool broad spectrum antibiotic activity of the present invention, energy establishment gram negative bacteria, positive bacteria, yeast and mycete; 2) not containing traditional preservatives and antibacterial, is the compound system that can support " without adding antiseptic " concept for cosmetics fully, and zest is low, and is safe; 3) fine with most cosmetic material compatibility; Its bacteriostasis is not subjected to the impact of surfactant in the cosmetics, protein and Chinese herbal medicine additive.
The specific embodiment
The present invention is further described below by specific embodiment; should be pointed out that for the person of ordinary skill of the art, under the prerequisite that does not break away from the principle of the invention; can also make some modification and improvement, these also should be considered as belonging to protection scope of the present invention.
Embodiment 1: a kind of cosmetics preservative, mainly the component by following mass percent forms: caprylhydroxamic acid 10%, phenethanol 40%, methyl propanediol 50%.
The present invention can replace traditional preservatives and apply in the cosmetics, and another characteristics of antiseptic of the present invention are still efficiently antibacterial in the pH value neutral environment, and the effect of other most of antiseptic substitutes is not very desirable in this environment.
The application of antiseptic in preparation hair conditioner among the embodiment 1, specific as follows:
The prescription of hair conditioner such as following table 1:
Table 1 hair conditioner
Operating procedure:
1, the composition except TC-1214 and TC-1233 in the oil-phase component is heated to 75 ℃ for subsequent use;
2, dispersed with stirring in cationic hydroxyethyl cellulose, the HEC adding water pot is even, be heated to 70-75 ℃;
3, when water is heated to 70-75 ℃, the oil phase that obtains in step 1) under stirring adds in the emulsifying pot; After oil phase adds, the beginning emulsifying;
4, cooling down is to 55-60 ℃, and the pH value that sampling detects this moment is 4.65, with homogeneous mixture and the antiseptic (PrzvFree of TC-1214 and TC-1233
TM1840) add in the emulsifying pot, but homogenizing 3 minutes;
5, continue to be cooled to 40-45 ℃, add the P.O., the essence that disperseed with deionized water in advance, stir and got final product discharging in 10-15 minute.
Embodiment 2: substantially the same manner as Example 1, difference is preservative substance formula: caprylhydroxamic acid 8%, phenethanol 45%, methyl propanediol 47%.
The application of antiseptic in preparation anhydrous formulations makeup remover among the embodiment 2, specific as follows:
The prescription of makeup remover such as following table 2:
Table 2 makeup remover
Embodiment 3: substantially the same manner as Example 1, difference is preservative substance formula: caprylhydroxamic acid 12%, phenethanol 38%, methyl propanediol 50%.
The application of antiseptic in the preparation emulsification system among the embodiment 3, specific as follows:
The prescription of antiallergic moisturiser such as following table 3:
Table 3 antiallergic moisturiser
Operating procedure:
1., accurately take by weighing each raw material of A phase (oil phase), the heated and stirred dissolving, temperature is controlled at 80 ± 2 ℃; (annotate: the suggestion cyclopentasiloxane adds before oil, water emulsifying);
2., B phase (water): after 1,2 premixings are uniformly dispersed mutually with B, add in the deionized water, heated and stirred is to fully dissolving, to about 90 ℃, stopped heating, other composition of adding B phase, continue to stir, until fully dissolving, temperature is controlled at about 85 ℃ and gets final product before the emulsifying;
3., oil phase sucks first in the emulsifying pot, sucking water under constantly stirring, open homogenizing and carry out emulsifying 15min;
4., when cooling to 60 ℃, improve the scraper plate mixing speed, 1 of adding C phase; Then 48 ℃ add 1 and 2 in mutually of D, stir;
5., when treating that temperature drops to 45 ℃～50 ℃ mastic receipts cream, stop to stir discharging.Sampling Detection, pH value: 6.50.
Embodiment 4: substantially the same manner as Example 1, difference is preservative substance formula: caprylhydroxamic acid 8%, phenethanol 38%, methyl propanediol 54%.
The application of antiseptic in the preparation table surfactant system among the embodiment 4, specific as follows:
The prescription of anti-dandruff submissive shampoo such as following table 4:
The anti-dandruff submissive shampoo of table 4
Operating procedure:
1, C-14-S is scattered in obtains C-14-S solution in the deionized water;
2, TC-8025 is added in the C-14-S solution again, add again EDTA-2Na and obtain mixed liquor, mixed liquor is joined in the pot;
3, again AESA, LSA are added in the pot, be heated to 75-80 ℃ of dissolving;
4, again pearlescent flake, CMEA, cetostearyl alcohol, TC-23 are mixed, are heated to 80 ℃, under stirring, add in the pot, mixed 15-20 minute;
5, be cooled to 50 ℃, add successively TC-1352 emulsified silicone oil, CAB-35 and antiseptic, essence;
6, get after appropriate amount of deionized water disperses P.O., in the adding system;
7, stir afterwards with Fructus Citri Limoniae acid for adjusting pH value to 6.0-6.5, be adjusted to qualified rear discharging.
Embodiment 5: the prescription of antiseptic is identical with embodiment 1.
The application of antiseptic in preparation emulsification system (low pH value prescription), specific as follows:
Prescription such as the following table 5 of the U.S. black frost of DHA:
The U.S. black frost of table 5 DHA
Final products pH value: 2.50
Operating procedure:
1., accurately take by weighing each raw material of A phase (oil phase), the heated and stirred dissolving, temperature is controlled at 80 ± 2 ℃;
2., B phase (water): with B mutually each heating raw materials be stirred to fully dissolving, to 90 ± 2 ℃, stopped heating, temperature is controlled at 80 ± 3 ℃ and gets final product before the emulsifying;
3., oil phase sucks first in the emulsifying pot, sucking water under constantly stirring, open homogenizing and carry out emulsifying 15min;
4., when cooling to 48 ℃, improve the scraper plate mixing speed, 1,2 of adding C phase, continuation stirring;
5., treat that temperature drops to when being lower than 40 ℃, add the D phase, stir the sampling Detection pH value: 2.50, discharging.
The application of antiseptic in preparation meta-alkalescence soap base bath oil system (high pH value prescription) among the embodiment 6, specific as follows:
The prescription of antipruritic skin-active bath oil such as following table *:
The antipruritic skin-active bath oil of table 6 (light)
Final products pH value: 8.0
Operating procedure is as follows:
One, 3 in mutually of A added in the load weighted deionized water, heated and stirred is dissolved to transparent, adds 1 in mutually of A again, and temperature is controlled at 80 ~ 85 ℃, adds 4 in mutually of A again; Behind CL, add 11,5,6,7 in mutually of A, until completely dissolved, behind insulated and stirred, the reaction 40-50min, add successively 8,9,12 in mutually of A, insulation, stir 20min, add 10,13 in mutually of A, stir 5min after, open cooling water temperature;
Add B phase 1,2,3 when two, cooling to 48 ℃, stir 15 minutes after the Uniform Dispersion dissolving, the sampling Detection pH value is: 8.0.
Embodiment 7: the preservation challenge test
Through check, detect use amount of the present invention according to criterion BP 2009APPX.XVI C/EP 6.25.1.3: 1.0%, this use amount makes reference with anticorrosion challenge result of the test, because when doing the preservation challenge test be 1% concentration of usefulness.
Its preservation challenge result of the test in cosmetics sees table 7 for details;
Table 7
Can draw to draw a conclusion from upper table:
Antibacterial: reduce 3 orders of magnitude (99.9%) in 14 days, lose growth in 28 days;
Yeast and mold: reduce 1 order of magnitude (99%) in 14 days, lose growth in 28 days;
The minimal inhibitory concentration result of the test of caprylhydroxamic acid (CHA) sees Table 8:
Table 8
The result shows, CHA to the Aspergillus niger minimal inhibitory concentration is: 0.078%
Above-mentioned cosmetics preservative does not contain traditional preservatives and antibacterial, and it becomes to be grouped into to antibacterial and the multi-functional of the splendid inhibition of fungus by having, and is the compound system that can support " without adding antiseptic " concept for cosmetics fully.This product has broad spectrum antibiotic activity, energy establishment gram negative bacteria, positive bacteria, yeast and mycete, and the adding of caprylhydroxamic acid (CHA) more strengthens its mould fungus inhibition effect.
Embodiment 8: toxicology test
One, material and animal
1, tested material and preparation: sample is liquid, takes by weighing sample 1000,2150,4640,10000,21500mg, adds pure water to 20ml, and fully mixing is mixed with tested material.
2, animal and feedstuff: 40 of healthy ICR mices, the cleaning level, body weight 18.3-22.0g, male and female half and half are provided by Nanjing Medical University's Experimental Animal Center; The animal feed source: the two lion laboratory animal feed technology Services Co., Ltd in Suzhou provide;
3, experimental condition: SPF level laboratory animal environment, occupancy permit number: SYXK (Soviet Union) 2007-0020 number: ambient temperature: 22 ± 2 ℃, relative humidity 40-70%, the animal adaptation 3d that in feeding environment, quarantine before the test, aquesterilisa is freely drunk.
Two, test method:
Horn method.The animal overnight fasting, with laboratory animal female by body weight be randomized into 2150,4640,10000,21500mg/kg.b.wt, 4 dosage groups; Male by body weight be randomized into 1000,2150,4640,10000mg/kg.b.wt, 4 dosage groups, gavage of each dosage group per os, capacity is 20ml/kg.b.wt, 4h feed after the administration, 14 days observation periods, observe also poisoning manifestations, death toll and the death time of itemized record animal.The animal of putting to death with humanity that is poisoned to death carries out the gross anatomy inspection immediately.
Three, result of the test
About 15min after the male and female mice contamination occurs according to fast, the prostrate poisoning manifestations such as motionless of the breathing heart rate of dosage, and death occurs in the 0.5h-2d, recovers gradually behind the surviving animals 3d, and gross anatomy shows no obvious abnormalities.
Four, conclusion (of pressure testing)
This sample is to female mice acute oral LD
50Value is 5840(4390-7940) mg/kg.b.wt, the nontoxic level in true border is to male mice acute oral LD
50Value is 4300(2950-6260) mg/kg.b.wt, belong to low toxicity level.
Embodiment 9: single-use skin zest, corrosion test
Materials and methods:
1, tested material: sample is liquid, directly as tested material.
2, animal and feeding environment: healthy without 4 of skin disease New Zealand white rabbit, regular grade, kind warren, Nanjing provides, the quality certification number: SCXK (Soviet Union) 2007-0004 number, body weight 2.1-2.8kg.The laboratory animal environmental facility quality certification number: SYXK (Soviet Union) 2007-0020 number: ambient temperature: 22 ± 2 ℃, relative humidity 40-70%, feed resource and card number: Jiangsu Province work in coordination with the medical bioengineering company limited, and the A that revives raises new word (2002) No. 009.
3, test method: 24h before the test, family's rabbit back spinal column diamond wool to be cut, the unhairing scope respectively is 3cm*3cm.During test, get tested material approximately 0.5ml spread upon on the side skin of unhairing, application area 2.5cm*2.5cm covers with two-layer gauze and one deck preservative film, fixes with nonirritant adhesive plaster and binder, opposite side skin in contrast.Application time 4h, application is washed residual tested material off with warm water after finishing, 1h, 24h, 48h, 72h observe dermoreaction after removing tested material, by table 1 scoring in " cosmetics health standard ", carry out the skin irritation strength grading by table 2 in " cosmetics health standard " when experiment finishes.
4, result of the test:
Have no zest and other toxic actions, tested material is nonirritant to the Rabbits with Acute skin irritation.The irritant reaction integration sees the following form.
Tested material is to Rabbits with Acute irritation test result
Embodiment 10: acute ocular zest, corrosion test
One, material and animal:
1, tested material: sample is liquid, and the highest working concentration is 1.2%(stock solution: pure water preparation), get stock solution 1.2ml add pure water to the abundant mixing of 100ml as tested material.
2, animal and feeding environment: 3 of healthy adult New Zealand white rabbit, regular grade, kind warren, Nanjing provides, the quality certification number: SCXK (Soviet Union) 2007-0004 number, body weight 2.4-2.8kg tests 3d in experimental situation, 24h checks eyes before the test, gets without ophthalmic person and tests.The laboratory animal environmental facility quality certification number: SYXK (Soviet Union) 2007-0020 number: ambient temperature: 22 ± 2 ℃, relative humidity 40-70%, feed resource and card number: Jiangsu Province work in coordination with the medical bioengineering company limited, and the A that revives raises new word (2002) No. 009.
Two, test method
Get tested material 0.1ml and directly splash in the rabbit one branch hole conjunctival sac, closed eyelid 1s does not wash, another eye is not processed and is made own control, 1h, 24h, 48h, 72h, 4d, 7d observe behind eye drip, a record eye irritant reaction, and behind 24h each the time drop fluorescein sodium check.When finishing, experiment carries out the skin irritation strength grading by table 3 in " cosmetics health standard ".
Three, result of the test
Have no zest other toxic actions in addition, the irritant reaction integration sees the following form.
The highest working concentration of this sample is that 1.2% pair of Rabbits with Acute eye irritation is microstimulation.
Claims (6)
1. a broad-spectrum antiseptic cosmetics preservative is characterized in that, comprises the component of following mass percent: caprylhydroxamic acid 8-12%, phenethanol 38-45%, methyl propanediol 46-54%.
2. the application of broad-spectrum antiseptic cosmetics preservative claimed in claim 1 in the preparation cosmetics.
3. the application of broad-spectrum antiseptic cosmetics preservative claimed in claim 2 in the preparation cosmetics is characterized in that the addition of described antiseptic is to be 0.7～1.2%.
4. the application of broad-spectrum antiseptic cosmetics preservative claimed in claim 2 in the preparation cosmetics is characterized in that the pH value scope of application of described antiseptic is 2～8.
5. broad-spectrum antiseptic cosmetics preservative claimed in claim 2 is characterized in that in the application of preparation in the cosmetics, add described antiseptic after, heating is no more than 2 hours in the time of 90 ℃, heating is no more than 6 hours in the time of 60 ℃.
6. the application of broad-spectrum antiseptic cosmetics preservative claimed in claim 2 in the preparation cosmetics is characterized in that, when described cosmetics are the cosmetics of surfactant system, adds described antiseptic below 60 ℃ in the cooling later stage.
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| CN104586679A (en) * | 2014-12-22 | 2015-05-06 | 广州环亚化妆品科技有限公司 | Preservative-free mask composition and preparation method thereof |
| CN105342869A (en) * | 2015-09-02 | 2016-02-24 | 张愉 | Composition with anticorrosion effect and preparation method and application thereof |
| CN105411923A (en) * | 2015-12-03 | 2016-03-23 | 南京斯拜科生化实业有限公司 | Natural broad-spectrum anticorrosion composition containing grapefruit seed extract and application thereof |
| CN105935342A (en) * | 2015-08-19 | 2016-09-14 | 珠海姗拉娜化妆品有限公司 | Composition containing substitute for existing preservative in cosmetics |
| CN107595662A (en) * | 2016-02-10 | 2018-01-19 | 伊诺莱克斯投资公司 | Reduce the cooperative compositions, preparation and correlation technique of UV-induced lipid peroxidation |
| CN107714497A (en) * | 2017-11-29 | 2018-02-23 | 诺斯贝尔化妆品股份有限公司 | A kind of no added preservative used for cosmetic |
| CN109541195A (en) * | 2018-11-22 | 2019-03-29 | 苏州纳工坊健康科技有限公司 | Fungicide Oral toxicity safety testing method and sterilization agent storage device |
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| CN104586679A (en) * | 2014-12-22 | 2015-05-06 | 广州环亚化妆品科技有限公司 | Preservative-free mask composition and preparation method thereof |
| CN105935342A (en) * | 2015-08-19 | 2016-09-14 | 珠海姗拉娜化妆品有限公司 | Composition containing substitute for existing preservative in cosmetics |
| CN105342869A (en) * | 2015-09-02 | 2016-02-24 | 张愉 | Composition with anticorrosion effect and preparation method and application thereof |
| CN105411923B (en) * | 2015-12-03 | 2018-11-02 | 南京斯拜科生化实业有限公司 | Natural broad spectrum preservation composition containing grapefruit seed extract and its application |
| WO2017092177A1 (en) * | 2015-12-03 | 2017-06-08 | 南京斯拜科生化实业有限公司 | Natural broad-spectrum preservative composition comprising grapefruit seed extract and use thereof |
| CN105411923A (en) * | 2015-12-03 | 2016-03-23 | 南京斯拜科生化实业有限公司 | Natural broad-spectrum anticorrosion composition containing grapefruit seed extract and application thereof |
| US10342236B2 (en) | 2015-12-03 | 2019-07-09 | Spec-Chem Industry Inc. | Natural broad-spectrum preservative composition containing citrus grandis fruit extract and its use |
| CN107595662A (en) * | 2016-02-10 | 2018-01-19 | 伊诺莱克斯投资公司 | Reduce the cooperative compositions, preparation and correlation technique of UV-induced lipid peroxidation |
| CN107595662B (en) * | 2016-02-10 | 2022-03-01 | 伊诺莱克斯投资公司 | Synergistic compositions, formulations and related methods for reducing ultraviolet-induced lipid peroxidation |
| CN107714497A (en) * | 2017-11-29 | 2018-02-23 | 诺斯贝尔化妆品股份有限公司 | A kind of no added preservative used for cosmetic |
| CN112867770A (en) * | 2018-10-26 | 2021-05-28 | 宝洁公司 | Absorbent article having graphic printed with preservative-free ink and method of making the same |
| CN112888751A (en) * | 2018-10-26 | 2021-06-01 | 宝洁公司 | Absorbent article having graphic printed with preservative-free ink and method of making the same |
| CN112888751B (en) * | 2018-10-26 | 2023-01-20 | 宝洁公司 | Absorbent article having graphic printed with preservative-free ink and method of making the same |
| CN109541195A (en) * | 2018-11-22 | 2019-03-29 | 苏州纳工坊健康科技有限公司 | Fungicide Oral toxicity safety testing method and sterilization agent storage device |
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| CN110840765A (en) * | 2019-12-12 | 2020-02-28 | 陕西省石油化工研究设计院 | Antiseptic and bactericidal composition and preparation method thereof |
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Application publication date: 20130213 |