CN102895467A - Medicine composition, pill and application of medicine composition - Google Patents
Medicine composition, pill and application of medicine composition Download PDFInfo
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- CN102895467A CN102895467A CN201210445569XA CN201210445569A CN102895467A CN 102895467 A CN102895467 A CN 102895467A CN 201210445569X A CN201210445569X A CN 201210445569XA CN 201210445569 A CN201210445569 A CN 201210445569A CN 102895467 A CN102895467 A CN 102895467A
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Abstract
The invention provides a medicine composition. The medicine composition contains the following raw materials: angelica sinensis, fructus lycii, raw fallopian multiflora, eclipta alba, ligusticum chuanxiong hort, rhizoma cibotii, root of rehmannia, rehmannia glutinosa, dioscorea opposite, semen sesame nigrum, semen juglandis, fructus ligustri lucidi, cortex moutan, rhizoma alismatis and poria with hostwood. The invention further provides a pill which contains the medicine composition and the application of the medicine composition. The medicine composition provided by the invention can effectively treat alopecia.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition and pill and and use, more specifically the present invention relates to a kind of for prevention or the pharmaceutical composition of hair growth, contain the pill of this pharmaceutical composition, and pharmaceutical composition is for the preparation of the application in the medicine of prevention or hair growth.
Background technology
Alopecia refers to the phenomenon of alopecia.The hair that normally comes off all is the hair that is in catagen and resting stage, constantly is in dynamic equilibrium owing to enter catagen with the hair that newly enters trophophase, so can keep the hair of normal quantity, more than is exactly normal physiologic alopecia.The pathologic alopecia refers to unusual or excessive the coming off of hair.
According to the degree of alopecia, can be divided into alopecia totalis and alopecia areata.Alopecia totalis refers to that hair almost all or all comes off, and severe patient even whole body hair also all come off such as eyebrow, beard; Alopecia areata refers to that hair portion comes off, and forms the alopecia position of similar speckle.According to the development speed of alopecia, can be divided into defluxion and chronic alopecia.
No matter be alopecia totalis or alopecia areata, all patient's personal image caused some negative effects.In order to prevent or treat the pathologic alopecia, people develop various medicines, comprise the various medicines of for oral administration and external, but up to the present, also do not have a kind of medicine effectively to prevent or hair growth.
Summary of the invention
The object of the present invention is to provide a kind of pharmaceutical composition for prevention or hair growth.
Another object of the present invention provides pill and the application thereof that contains this pharmaceutical composition.
The invention provides a kind of pharmaceutical composition, said composition contains following raw material: Radix Angelicae Sinensis, Fructus Lycii, Radix Polygoni Multiflori, Herba Ecliptae, Rhizoma Chuanxiong, Rhizoma Cibotii, the Radix Rehmanniae, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Semen Sesami Nigrum, Semen Juglandis, Fructus Ligustri Lucidi, Cortex Moutan, Rhizoma Alismatis and Poria cum Radix Pini, wherein, with respect to the Radix Angelicae Sinensis of 100 weight portions
The content of Fructus Lycii can be the 10-1000 weight portion, is preferably the 30-500 weight portion;
The content of Radix Polygoni Multiflori can be the 10-1000 weight portion, is preferably the 30-500 weight portion;
The content of Herba Ecliptae can be the 10-1000 weight portion, is preferably the 30-500 weight portion;
The content of Rhizoma Chuanxiong can be the 10-1000 weight portion, is preferably the 30-500 weight portion;
The content of Rhizoma Cibotii can be the 10-1000 weight portion, is preferably the 30-500 weight portion;
The content of the Radix Rehmanniae can be the 10-1000 weight portion, is preferably the 30-500 weight portion;
The content of Radix Rehmanniae Preparata can be the 10-1000 weight portion, is preferably the 30-500 weight portion;
The content of Rhizoma Dioscoreae can be the 10-1000 weight portion, is preferably the 30-500 weight portion;
The content of Semen Sesami Nigrum can be the 10-1000 weight portion, is preferably the 30-500 weight portion;
The content of Semen Juglandis can be the 10-1000 weight portion, is preferably the 30-500 weight portion;
The content of Fructus Ligustri Lucidi can be the 10-1000 weight portion, is preferably the 30-500 weight portion;
The content of Cortex Moutan can be the 10-1000 weight portion, is preferably the 30-500 weight portion;
The content of Rhizoma Alismatis can be the 10-1000 weight portion, is preferably the 30-500 weight portion;
Poria cum Radix Pini's content can be the 10-1000 weight portion, is preferably the 30-500 weight portion.
Described raw material is preferably powder, and particle mean size can be the 80-150 order.
Radix Angelicae Sinensis is the dry root of umbelliferae angelica (Angelica sinensis (Oliv.) Diels).
Fructus Lycii is the dry mature fruit of matrimony vine of solanaceae plant (Lycium barbarum L.).
Radix Polygoni Multiflori is that the rhizome with Radix Polygoni Multiflori digs rear convection drying and forms.
Herba Ecliptae is the medicinal part of feverfew Herba Ecliptae (Eclipta prostrata L.).
Rhizoma Chuanxiong is the rhizome of samphire Rhizoma Chuanxiong (Ligusticum chuanxiong Hort.).
Rhizoma Cibotii is the dry rhizome of Dicksoniaceae plant Rhizoma Cibotii (Cibotium barometz (L.) J.Sm.).
The Radix Rehmanniae is the fresh or dry tuber of Scrophulariaceae herbaceos perennial Radix Rehmanniae (Rehmannia glutinosa Libosch.).
Radix Rehmanniae Preparata is that the tuber of Scrophulariaceae herbaceos perennial Radix Rehmanniae (Rehmannia glutinosa Libosch.) forms through the process of preparing Chinese medicine.
Rhizoma Dioscoreae is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae (Dioscorea opposita).
Semen Sesami Nigrum is the dry mature seed of Pedaliaceae plant sesame (Sesamum indicum L.).
Semen Juglandis is the dry mature seed of juglandaceae plant Semen Juglandis (Junglans regia L.).
Fructus Ligustri Lucidi is the dry mature fruit of Oleaceae plants Fructus Ligustri Lucidi (Ligustrum lucidum Ait.).
Cortex Moutan is the dry root bark of the perennial machaka plant of Ranunculaceae Paeonia suffruticosa (Paeonia suffruticosa Andr.).
Rhizoma Alismatis is the dry tuber of Alismataceae (Alismataceae) plant Rhizoma Alismatis Alisma orientale (Samuels) Juzep..
Poria cum Radix Pini is the sclerotium of the sleeping hole platymiscium Poria ((Poria cocos Schw.) Wolf) of Polyporaceae.
Above-mentioned various raw material can be bought the product that has cooked in market, also can obtain by the concocting method of routine, for example, can make with grinding by the medicinal part of plant being carried out drying.Dry method can or be dried naturally for oven dry, is preferably nature and dries.The method of grinding can be the Ginding process of field of Chinese medicines routine, and it is the 80-150 order that the condition optimization of grinding makes the particle mean size of described raw material.
Pharmaceutical composition of the present invention can make by described various raw materials are mixed.As long as the condition of mixing makes various raw material mix homogeneously.
Pharmaceutical composition of the present invention can prevent or the rational alopecia of curative effectively, and is all effective in cure to alopecia totalis, alopecia areata, defluxion and chronic alopecia, especially acute alopecia totalis.
Pill provided by the invention contains active component and adjuvant, and wherein, described active component is pharmaceutical composition provided by the invention.
Take the gross weight of pill as benchmark, the content of described active component can be the 10-90 % by weight, and the content of described adjuvant can be the 10-90 % by weight.
Described pill is preferably honeyed pill, and described Optimization of Adjuvant is Mel.
The preparation method of pill provided by the invention can comprise with active component and adjuvant mix, molding.
Take the gross weight of pill as benchmark, the consumption of described active component can be the 10-90 % by weight, and the consumption of described adjuvant can be the 10-90 % by weight.
Described Optimization of Adjuvant is Mel.The temperature of described mixing can be 100-130 ℃, and the time of mixing can be 10-60 minute.
The method of described molding can adopt the conventional forming method for the preparation of pill, for example the medicine piece that mixes formation can be put into pellet processing machine and become ball.
The invention provides described pharmaceutical composition for the preparation of the application in prevention or the medicine of hair growth.
Described alopecia can for alopecia totalis, alopecia areata, defluxion and chronic alopecia, be preferably acute alopecia totalis.
The specific embodiment
Below by embodiment the present invention is described in more detail.
The processing method of used raw material is as follows in following examples: will be ground to 120 orders after Radix Angelicae Sinensis, Fructus Lycii, Radix Polygoni Multiflori, Herba Ecliptae, Rhizoma Chuanxiong, Rhizoma Cibotii, the Radix Rehmanniae, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Semen Sesami Nigrum, Semen Juglandis, Fructus Ligustri Lucidi, Cortex Moutan, Rhizoma Alismatis and the Poria cum Radix Pini's drying respectively.
Embodiment 1-3
Embodiment 1-3 is for the preparation of pharmaceutical composition provided by the invention.
According to the consumption shown in the table 1 (all in weight portion) each raw material is mixed, make respectively pharmaceutical composition A 1 to A3.
Table 1
| Embodiment 1 | Embodiment 2 | Embodiment 3 | |
| The pharmaceutical composition numbering | ?A1 | ?A2 | ?A3 |
| Radix Angelicae Sinensis | ?100 | ?100 | ?100 |
| Fructus Lycii | ?50 | ?200 | ?400 |
| Radix Polygoni Multiflori | ?50 | ?200 | ?400 |
| Herba Ecliptae | ?50 | ?200 | ?400 |
| Rhizoma Chuanxiong | ?50 | ?200 | ?400 |
| Rhizoma Cibotii | ?50 | ?200 | ?400 |
| The Radix Rehmanniae | ?50 | ?200 | ?400 |
| Radix Rehmanniae Preparata | ?50 | ?200 | ?400 |
| Rhizoma Dioscoreae | ?50 | ?200 | ?400 |
| Semen Sesami Nigrum | ?50 | ?200 | ?400 |
| Semen Juglandis | ?50 | ?200 | ?400 |
| Fructus Ligustri Lucidi | ?50 | ?200 | ?400 |
| Cortex Moutan | ?50 | ?200 | ?400 |
| Rhizoma Alismatis | ?50 | ?200 | ?400 |
| Poria cum Radix Pini | ?50 | ?200 | ?400 |
Embodiment 4-6
Embodiment 4-6 is for the preparation of pill provided by the invention.
Mel is heated to 110 ℃, then the pharmaceutical composition A 1 to A3 that respectively embodiment 1-3 is prepared joins (A1 to A3 was respectively 1: 5,1: 1 and 5: 1 with the mass ratio of Mel) in the Mel, 110 ℃ of lower mixing 30 minutes, then naturally be cooled to join after the room temperature and make ball in the pellet processing machine, the kind of every ball is 3 grams, namely gets pill W1 to W3.
Embodiment 7-9
Embodiment 7-9 is used for illustrating the effect of pharmaceutical composition provided by the invention.
(1) to the therapeutic effect of acute alopecia totalis
Select the patient (20-60 year, 45 of male, 5 of women) of 60 acute alopecia totalis (the alopecia area is more than 90% in 2 months), be divided at random 3 treatment groups (every group of 20 patients).3 treatment groups are taken respectively pill W1 to W3, instructions of taking be every day sooner or later each once, each 5 balls, boiled water is oral.Observing effect after two months, the cure rate of 3 treatment groups is respectively 80%, 90% and 85%.Cure and to refer to that patient's alopecia area accounts for below 10% of the scalp gross area, cure rate refers to that the patient's that cures number accounts for the percentage ratio for the treatment of number.
(2) to the therapeutic effect of chronic alopecia areata
Select the patient (20-60 year, patient's alopecia area accounts for more than 20% of the scalp gross area, 70 of male, 20 of women) of 90 chronic alopecia areatas, be divided at random 3 treatment groups (every group of 30 patients).3 treatment groups are taken respectively pill W1 to W3, instructions of taking be every day sooner or later each once, each 5 balls, boiled water is oral.Observing effect after three months, the cure rate of 3 treatment groups is respectively 76.7%, 83.3% and 73.3%.Cure and to refer to that patient's alopecia area accounts for below 10% of the scalp gross area, cure rate refers to that the patient's that cures number accounts for the percentage ratio for the treatment of number.
From the result of above embodiment, pharmaceutical composition provided by the invention is hair growth effectively.
Claims (8)
1. pharmaceutical composition, said composition contains following raw material: Radix Angelicae Sinensis, Fructus Lycii, Radix Polygoni Multiflori, Herba Ecliptae, Rhizoma Chuanxiong, Rhizoma Cibotii, the Radix Rehmanniae, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Semen Sesami Nigrum, Semen Juglandis, Fructus Ligustri Lucidi, Cortex Moutan, Rhizoma Alismatis and Poria cum Radix Pini, wherein, with respect to the Radix Angelicae Sinensis of 100 weight portions
The content of Fructus Lycii is the 10-1000 weight portion;
The content of Radix Polygoni Multiflori is the 10-1000 weight portion;
The content of Herba Ecliptae is the 10-1000 weight portion;
The content of Rhizoma Chuanxiong is the 10-1000 weight portion;
The content of Rhizoma Cibotii is the 10-1000 weight portion;
The content of the Radix Rehmanniae is the 10-1000 weight portion;
The content of Radix Rehmanniae Preparata is the 10-1000 weight portion;
The content of Rhizoma Dioscoreae is the 10-1000 weight portion;
The content of Semen Sesami Nigrum is the 10-1000 weight portion;
The content of Semen Juglandis is the 10-1000 weight portion;
The content of Fructus Ligustri Lucidi is the 10-1000 weight portion;
The content of Cortex Moutan is the 10-1000 weight portion;
The content of Rhizoma Alismatis is the 10-1000 weight portion;
Poria cum Radix Pini's content is the 10-1000 weight portion.
2. compositions according to claim 1, wherein, with respect to the Radix Angelicae Sinensis of 100 weight portions,
The content of Fructus Lycii is the 30-500 weight portion;
The content of Radix Polygoni Multiflori is the 30-500 weight portion;
The content of Herba Ecliptae is the 30-500 weight portion;
The content of Rhizoma Chuanxiong is the 30-500 weight portion;
The content of Rhizoma Cibotii is the 30-500 weight portion;
The content of the Radix Rehmanniae is the 30-500 weight portion;
The content of Radix Rehmanniae Preparata is the 30-500 weight portion;
The content of Rhizoma Dioscoreae is the 30-500 weight portion;
The content of Semen Sesami Nigrum is the 30-500 weight portion;
The content of Semen Juglandis is the 30-500 weight portion;
The content of Fructus Ligustri Lucidi is the 30-500 weight portion;
The content of Cortex Moutan is the 30-500 weight portion;
The content of Rhizoma Alismatis is the 30-500 weight portion;
Poria cum Radix Pini's content is the 30-500 weight portion.
3. compositions according to claim 1 and 2, wherein, described raw material is powder, particle mean size is the 80-150 order.
4. pill, this pill contains active component and adjuvant, and wherein, described active component is the described pharmaceutical composition of any one among the claim 1-3.
5. pill according to claim 4, wherein, take the gross weight of pill as benchmark, the content of described active component is the 10-90 % by weight, the content of described adjuvant is the 10-90 % by weight.
6. according to claim 4 or 5 described pills, wherein, described pill is honeyed pill, and described adjuvant is Mel.
Among the claim 1-3 the described pharmaceutical composition of any one for the preparation of the application in prevention or the medicine of hair growth.
8. application according to claim 7, wherein, described alopecia is acute alopecia totalis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210445569.XA CN102895467B (en) | 2012-11-09 | 2012-11-09 | Medicine composition, pill and application of medicine composition |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210445569.XA CN102895467B (en) | 2012-11-09 | 2012-11-09 | Medicine composition, pill and application of medicine composition |
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| Publication Number | Publication Date |
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| CN102895467A true CN102895467A (en) | 2013-01-30 |
| CN102895467B CN102895467B (en) | 2014-03-12 |
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| CN201210445569.XA Active CN102895467B (en) | 2012-11-09 | 2012-11-09 | Medicine composition, pill and application of medicine composition |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142911A (en) * | 2013-03-14 | 2013-06-12 | 章磊 | Chinese medicine composition for treating alopecia and preparation method thereof |
| CN104367709A (en) * | 2014-11-19 | 2015-02-25 | 杜军伟 | Traditional Chinese medicine for treating alopecia |
| CN107441417A (en) * | 2017-07-12 | 2017-12-08 | 姚莲琴 | A kind of Anti-hair loss traditional Chinese medicine composition containing the root bark of shaggy-fruited dittany |
| CN111956712A (en) * | 2020-08-20 | 2020-11-20 | 李春晖 | Traditional Chinese medicine formula for treating alopecia areata |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100536885C (en) * | 2007-09-07 | 2009-09-09 | 吴法超 | Medicine for treating phalacrosis and restoring hair |
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2012
- 2012-11-09 CN CN201210445569.XA patent/CN102895467B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100536885C (en) * | 2007-09-07 | 2009-09-09 | 吴法超 | Medicine for treating phalacrosis and restoring hair |
Non-Patent Citations (2)
| Title |
|---|
| 刘燕婷，等: "中医治疗斑秃概述", 《实用中医药杂志》 * |
| 朱明芳: "斑秃的中医研究进展", 《湖南中医药导报》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142911A (en) * | 2013-03-14 | 2013-06-12 | 章磊 | Chinese medicine composition for treating alopecia and preparation method thereof |
| CN104367709A (en) * | 2014-11-19 | 2015-02-25 | 杜军伟 | Traditional Chinese medicine for treating alopecia |
| CN107441417A (en) * | 2017-07-12 | 2017-12-08 | 姚莲琴 | A kind of Anti-hair loss traditional Chinese medicine composition containing the root bark of shaggy-fruited dittany |
| CN111956712A (en) * | 2020-08-20 | 2020-11-20 | 李春晖 | Traditional Chinese medicine formula for treating alopecia areata |
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| Publication number | Publication date |
|---|---|
| CN102895467B (en) | 2014-03-12 |
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