CN102824238A - Schlemm tube expansion bracket and combined body thereof - Google Patents
Schlemm tube expansion bracket and combined body thereof Download PDFInfo
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- CN102824238A CN102824238A CN2012101984460A CN201210198446A CN102824238A CN 102824238 A CN102824238 A CN 102824238A CN 2012101984460 A CN2012101984460 A CN 2012101984460A CN 201210198446 A CN201210198446 A CN 201210198446A CN 102824238 A CN102824238 A CN 102824238A
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Abstract
The invention relates to a Schlemm tube expansion bracket and a combined body of the Schlemm tube expansion bracket. The expansion bracket is a hollow cylindrical shell; the cylindrical surface is formed by a continuous round curve loop bent and folded from an alloy wire; the surface of the alloy wire is coated with a coating of 10-50 microns, and the coating comprises an adhesive bottom layer and a drug layer. The tube expansion bracket disclosed by the invention can reduce the damage to the wall of a Schlemm tube, reduces restenosis and multiplication occurrence rate of a cavity of the Schlemm tube, and has good soft performance. The Schlemm tube expansion bracket disclosed by the invention can effectively and lastingly release the drug on a narrow lesion site, and guarantees local precise drug delivery of a target lesion point while reducing a serious damage on the wall of the Schlemm tube caused by the bracket wall, and therefore, the restenosis occurrence rate of the Schlemm tube can be effectively reduced, thereby achieving the purposes of promoting aqueous humour discharge, reducing intraocular tension and treating glaucoma.
Description
Technical field
The present invention relates to a kind of ophthalmic support, especially relate to and a kind ofly be used for inserting that ophthalmic executes Lai Mushi pipe (Schlemm) executes Lai Mushi pipe (Schlemm) expandable stent and assembly thereof.
Background technology
Glaucoma is a kind of very serious public health disease, and glaucoma is a kind of optic nerve sick (optic nerve disease) more specifically, and it is not smooth that it is generally the ophthalmic aqueous humor drainage, produces intraocular pressure and raises.Pressure in the eyes raises, and makes optic nerve injury, and field range is dwindled.When there is lasting high intraocular pressure in the patient, can cause the patient blind.
Eyes are hollow-core construction, comprise the transparent fluid that is called " aqueous humor ".Aqueous humor is formed in the back room of eyes through the speed of corpus ciliare with about 2.5 microlitre per minutes.The fluid that produces with suitable constant speed is process around the crystalline lens again, and gets in the anterior chamber of eyes through the pupil opening in the iris.In case in the anterior chamber, this fluid is discharged eyes through two different routes.In " uvea sclera (uveoscleral) " route, fluid filters between capsulociliary muscle fiber.This route accounts for about 10 of the aqueous humor that flows out human body.The major avenues of approach of flowing out the aqueous humor of human body is through " tubule " route, and this route relates to trabecular reticulum and Schlemm pipe (executing the Lai Mushi pipe).
Trabecular reticulum and execute Lai Mushi pipe (Schlemm) junction between iris and sclera.Trabecular reticulum is the wedge structure that extends around the periphery of eyes.It comprises the collagen bundle that is arranged to three-dimensional screen shape structure, and this collagen bundle aligns with the cell monolayer that is called trabecular meshwork cell.The outer wall of trabecular reticulum overlaps with the inwall of executing Lai Mushi pipe (Schlemm).Executing Lai Mushi pipe (Schlemm) is the tubular structure that extends around the periphery of cornea.In the adult, think execute Lai Mushi pipe (Schlemm) by at a distance from being divided into a series of independently closed end pipes.
The aqueous humor fluid is crossed the inwall of executing Lai Mushi pipe (Schlemm) and is got in this pipe through the space between the girder bundle, and gets into the episcleral veins system through collecting conduit from a series of (about 25) that execute Lai Mushi pipe (Schlemm) discharge.Under normal circumstances, the generation of aqueous humor equals the discharge of aqueous humor, and intraocular pressure remains in the scope of 15 to 21 mmHg quite consistently.In glaucoma, high unusually through the resistance of tubule outflow system.
In primary open-angle glaucoma (this primary open-angle glaucoma is modal glaucoma form), think that unusual resistance is the outside and the inwall of executing Lai Mushi pipe (Schlemm) along trabecular reticulum.Primary open-angle glaucoma accounts for whole glaucomatous about 85 percent.The glaucoma of other form (for example angle sealing glaucoma and supervention property glaucoma) also relates to through executing effluenting of (Schlemm) path of Lai Mushi pipe and reducing, but the resistance increase is owing to other reason, for example mechanical obstruction, inflammation remains, cell obstruction etc.
Owing to increase resistance, will accumulate the aqueous humor fluid, because aqueous humor can not enough be discharged soon.When fluid accumulation, the intraocular pressure (IOP) in the eyes raises.Elevated IOP will be compressed the neural axon in the optic nerve, also possibly influence the blood vessel of optic nerve is supplied with.Optic nerve sends vision to brain from eyes.Feasible glaucoma treatment method only reduces intraocular pressure at present.
Glaucomatous clinical treatment adopts progressively mode.Drug therapy normally first treatment is selected.Can be topical or oral administration, the effect of these medicines is to reduce the aqueous humor generation, and perhaps they are used to increase discharge.Present obtainable medicine has a lot of serious adverse, comprising: congestive heart disease, rapid breathing, hypertension, depression, nephrolith, aplastic anemia, sexual dysfunction and death.The compliance of medicine is a subject matter, according to estimates, surpasses half the glaucoma patient and does not follow their orthochronous dosage, thereby cause the fluctuation of intraocular pressure, causes optic nerve injury and defect of visual field.
When reducing intra-ocular pressure power, carry out laser trabeculoplasty when under medication usually.In laser trabeculoplasty, the heat energy that is produced by laser is applied on a plurality of discontinuity poinies in the trabecular reticulum.According to thinking, laser energy stimulates the metabolism of trabecular meshwork cell with certain mode, and changes the extracellular material in trabecular reticulum.In about patient of 80 percent, the flow of aqueous humor output increases, and IOP reduces.But, this effect can not continue the long period usually, and 50 percent patient developed into high pressure in 5 years.Laser surgery can not be reused usually.In addition, the laser trabeculoplasty transplantation can not effectively be treated the patient's who is lower than 50 years old primary open-angle glaucoma, can not effectively treat angle sealing glaucoma and a lot of supervention property glaucomas.When the laser trabeculoplasty transplantation can not fully reduce pressure, will carry out filtration surgery so.Through filtration surgery, form the hole at sclera and angular zone.This hole makes aqueous humor leave eyes through optional route.
It is trabeculectomy that glaucoma patient carries out processing mode the most usually, and this art formula can form artificial aqueous humor outflow pathway.Yet trabeculectomy can form the scarring of scleral flap, makes the artificial aqueous humor that forms flow out pathway closure, thereby causes that intraocular pressure raises once more, particularly for child and early youth.Successfully carrying out in the eyes of trabeculectomy at first, in three to five years, 80 percent will be owing to the scarring that filters passage lost efficacy after operation.Trabeculectomy has produced the path that makes aqueous humor go out ocular surface.Simultaneously, it has produced and has made the path of living in ocular surface and superciliary antibacterial entering eyes usually.When this thing happens, the interior eye infections of ophthalmia in possibly being called.Endophthalmitis causes permanent and bigger vision loss usually.
In addition, existing aqueous humor drainage device also can form the aqueous humor outflow pathway and reduce intraocular pressure.Aqueous humor drainage device is to be silicone tube, and an end of this silicone tube is installed on plastics (polypropylene or other synthetic) plate.For the aqueous humor part flow arrangement, in conjunctiva, form otch, thereby expose sclera.Plastic plate is sewn on the eyes posterior face, usually the crossing the line line.The hole of through thickness is formed in the eyes at the edge place through pin usually.Pipe inserts in the eyes through this hole.The outside of pipe is covered by donor sclera or pericardium.Put back to conjunctiva, and closure of incisions tightly.The aqueous humor part flow arrangement has a lot of complication.The wall that thickens of the scar tissue that forms around plastic plate provides certain resistance to outflow, much will limit reducing of eyes pressure in the eyes.In a lot of eyes,, therefore form hypotonia because it is also unrestricted to flow through the fluid stream of pipe.Absorbable stitching thread on a lot of doctor's surrounding tube subsystems, and wait for that this stitching thread dissolves after operation, this time is enough to form the scar cell around plate.Some device is included in the pressure sensitive valve in the pipe, but these valves can not be worked well.Operation is carried out in posterior orbit, and a lot of patients form eye muscle imbalance and diplopia after operation.For the aqueous humor part flow arrangement of prior art, produced the passage that makes in the antibacterial entering eyes, and possibly produce endophthalmitis.
Most of problem of existing glaucoma treatment device and processing is because aqueous humor is discharged to ocular surface from inside ofeye.Therefore, need the more system of accordance with physiology, discharge so that increase from the aqueous humor fluid of anterior chamber in executing Lai Mushi pipe (Schlemm).At most of glaucoma philtrum, resistance problem is to execute between Lai Mushi pipe (Schlemm) and the anterior chamber.Occur narrow or when subsiding, can cause the aqueous humor drainage obstacle, thereby intraocular pressure raises, and causes glaucoma when executing Lai Mushi pipe (Schlemm) chamber.
Summary of the invention
A kind of ophthalmic of inserting that The present invention be directed to aqueous humor drainage technology and provide is executed and is executed Lai Mushi pipe (Schlemm) support and assembly thereof in the Lai Mushi pipe (Schlemm); So that the increase aqueous humor to the outflow of executing Lai Mushi pipe (Schlemm), is used for glaucoma treatment from the anterior chamber.Technical scheme of the present invention is: a kind of Lai Mushi of executing pipe (Schlemm) expandable stent; Said expandable stent is the hollow housing of the face of cylinder or drum type face; Said housing is provided with passage; The overall diameter of housing is 0.2MM to 0.5MM, and shell length is 0.5MM to 4MM, and the wall thickness of housing is 0.04MM to 0.06MM.
Said housing is through circumferential skewing, the axial formed curve of inflection constitute the face of cylinder or drum type face repeatedly by tinsel; The curve of the said formation face of cylinder or drum type face is by co-axial alternate and right-handed screw ring and backpitch ring that put constitute; The lineal measure of the lineal measure of said right-handed screw ring and said backpitch ring is greater than said face of cylinder girth and less than two times of said face of cylinder girth; One end of the said right-handed screw ring that each is adjacent and the other end of said backpitch ring constitute one and flow back to folded tooth; The other end of the said right-handed screw ring that each is adjacent and an end of said backpitch ring constitute another and flow back to folded tooth; Said one flow back to folded tooth crown and the said crown that another flows back to folded tooth in opposite directions; Whenever flow back to and constitute teeth groove between the folded tooth, one of which row's inflection tooth and the teeth groove and inflection tooth each other corresponding also mutual embedding of teeth groove with another row, the smooth circle in the two ends of said cylinder sigmoid curves is blunt.
Said tinsel is made by titanium magnesium alloy or cochrome, and the shape of its cross section is circle, semicircle, ellipse, half elliptic or rectangle.
Said housing is a RF; This RF; Comprise a plurality of wavy annular supporting constructions unit, the annular supports construction unit is arranged in regular turn, and each is arranged between the corresponding crest of annular supports construction unit and is close; Each arrange between the corresponding trough of annular supports construction unit away from, between the crest that is close through the rod member connection.
A kind of Lai Mushi pipe (Schlemm) expandable stent of executing; Said expandable stent is a face of cylinder hollow housing; The said face of cylinder is to form successive circular curve circle by crooked 360 degree backs of an alloy silk circular arc and then crooked 360 degree of inflection circular arc to constitute; It is the expand end of diameter greater than the alloy filament diameter that said alloy silk has an end at least; Said alloy silk surface has and is coated with 10 microns coatings to 50 micron thick; Said coating comprises bonding bottom and medicine layer, and said medicine layer is that mitomycin, heparin mix, a kind of in the rapamycin, paclitaxel, polylactic acid poly ethanol copolymer, Merlon, phosphocholine, vinylpyrrolidone copolymer, fluoropolymer, styrene-isobutene .-styrene, polyethylene ethylene acetic acid.
Said bonding bottom is that the alloy silk is sticking attached to alloy silk surface through in containing the solution of bonding agent, soaking, drying; The thickness of said bonding bottom is 1/5th to 1/3rd of coating layer thickness, and said medicine layer is that the mode through ultrasonic atomization is coated on the bonding bottom.
The alloy wire ring that the said face of cylinder distributes and the spacing of alloy wire ring are 20 microns to 50 microns.
Said alloy silk is titanium magnesium alloy silk or cochrome silk.
A kind of Lai Mushi pipe (Schlemm) expandable stent assembly of executing; Comprise a face of cylinder hollow housing support and a support pushing body; The said face of cylinder is to form successive circular curve circle by crooked 360 degree backs of an alloy silk circular arc and then crooked 360 degree of inflection circular arc to constitute; It is the expand end of diameter greater than the alloy filament diameter that said alloy silk has an end at least, and said support pushing body is held face of cylinder hollow housing support.
Said support pushing body is a cylinder; A cylindrical end is a conical head; The cylindrical other end is provided with the baffle ring of projection; The diameter of baffle ring is provided with the convexity that connects rope yarn greater than 20 microns of face of cylinder hollow housing stent diameters on the outer face of baffle ring, face of cylinder hollow housing is inserted in cylinder and forms support assembly until pushing up baffle ring.
Said support pushing body is a cylindrical casing, and the end sealing of cylindrical casing is provided with the convexity that connects rope yarn on Closed End, and face of cylinder hollow housing inserts cylindrical casing and forms support assembly.
The present invention compared with prior art has following beneficial effect:
The Lai Mushi of executing pipe (Schlemm) expandable stent of the present invention can reduce cradle wall to executing the grievous injury that Lai Mushi pipe (Schlemm) wall causes; Reduce the incidence rate of restenosis and propagation; And have less prepackage diameter and better submissive performance, can and can arrive the far-end of executing Lai Mushi pipe (Schlemm) through the serious narrow Lai Mushi of executing pipe (Schlemm) zone.In addition; The Lai Mushi of executing of the present invention pipe (Schlemm) expandable stent can be with medicine effectively, discharge at the stenotic lesion position enduringly; Guarantee the local accurately administration of target lesion point in to the grievous injury of executing Lai Mushi pipe (Schlemm) wall and causing reducing cradle wall, therefore can more effectively reduce to execute the incidence rate of Lai Mushi pipe (Schlemm) restenosis, promote the aqueous humor eliminating thereby reach; Reduce intraocular pressure, treat glaucomatous purpose.
Description of drawings
Do further explain below in conjunction with accompanying drawing and embodiments of the invention:
Fig. 1 is the structural representation of the embodiment of the invention 1;
Fig. 2 is the structural representation of the embodiment of the invention 2;
Fig. 3 is the expanded view of Fig. 2;
Fig. 4 is the structural representation of the embodiment of the invention 3;
Fig. 5 is the decomposition texture sketch map of the embodiment of the invention 4;
Fig. 6 is the combinative structure sketch map of the embodiment of the invention 4;
Fig. 7 is the decomposition texture sketch map of the embodiment of the invention 5;
Fig. 8 is the combinative structure sketch map of the embodiment of the invention 5;
Fig. 9 is an elasticity microtubular sketch map;
Figure 10 is the sketch map that operation the present invention executes Lai Mushi pipe (Schlemm) expandable stent.
The specific embodiment
Embodiment 1;
As shown in Figure 1; A kind of Lai Mushi pipe (Schlemm) expandable stent of executing, said expandable stent is the hollow housing 1 on the face of cylinder, said housing is provided with passage 2; The overall diameter of housing is 0.2MM to 0.5MM; Shell length is 0.5MM to 4MM, and warding off of housing is thick in 0.04MM to 0.06MM, and said housing also can be the drum type face.
Said housing is through circumferential skewing, the axial formed curve of inflection constitute the face of cylinder or drum type face repeatedly by tinsel; The curve of the said formation face of cylinder or drum type face is by co-axial alternate and the right-handed screw ring put 3 constitutes with backpitch ring 4; The lineal measure of the lineal measure of said right-handed screw ring and said backpitch ring is greater than said face of cylinder girth and less than two times of said face of cylinder girth; One end of the said right-handed screw ring that each is adjacent and the other end of said backpitch ring constitute one and flow back to folded tooth 5; The other end of the said right-handed screw ring that each is adjacent and an end of said backpitch ring constitute another and flow back to folded tooth 6; Said one flow back to folded tooth crown and the said crown that another flows back to folded tooth in opposite directions; Whenever flow back to and constitute teeth groove between the folded tooth, one of which row's inflection tooth and the teeth groove and inflection tooth each other corresponding also mutual embedding of teeth groove with another row, the smooth circle in the two ends of said cylinder sigmoid curves is blunt.
The two ends of said cylindrical so or drum type face sigmoid curves are to being provided with the face of cylinder or drum type face inflection is converted into the blunt small circle ring of smooth circle 7.
The crown of said inflection tooth is a circular arc and to the face of cylinder or drum type in-plane bending.
Said tinsel is made by titanium magnesium alloy or cochrome, and the shape of its cross section is circle, semicircle, ellipse, half elliptic or rectangle.
Embodiment 2;
Referring to Fig. 2 and Fig. 3, the said housing of the another kind of structure of the present invention is a RF 8, this RF; Comprise a plurality of wavy annular supporting constructions unit 9; The annular supports construction unit is arranged in regular turn, and each is arranged between the corresponding crest of annular supports construction unit and is close, each arrange between the corresponding trough of annular supports construction unit away from; Connect through rod member 10 between the crest that is close, said rod member be shaped as C shape or W shape.
Among embodiment 1 and the embodiment 2, said housing is coated with the high molecular nanometer coating of being made up of the tissue growth inhibitor.
Embodiment 3;
A kind of Lai Mushi pipe (Schlemm) expandable stent of executing; As shown in Figure 4; Said expandable stent is a face of cylinder hollow housing; The said face of cylinder is to form successive circular curve circle 12 by alloy silk 11 a circular arcs bending 360 degree backs and then crooked 360 degree of inflection 11-1 circular arc to constitute, and this kind structure is higher than the face of cylinder intensity that the winding of single line circulation circular arc forms; Said alloy silk have at least an end be diameter greater than the terminal 11-2 of expanding of alloy filament diameter, this expands end and can fix a rope very easily, this rope is used for the convenient support that takes out; In order to make support have the function of carrying medicine and slowly discharging; Have on said alloy silk surface and to be coated with 10 microns coatings to 20 micron thick; Said coating comprises bonding bottom and medicine layer; Bonding bottom is used for medicine is bonded in the alloy silk, common bonding bottom uses be non-degradation polymer as: fluoride or degradable polymer are like polylactic acid, and above-mentioned two kinds of bonding bottoms are except helping to be bonded in medicine on the alloy silk; Also have the control drug release time, make medicine reach the effect of slow release; Said medicine layer is that mitomycin, heparin mix, a kind of in the rapamycin, paclitaxel, polylactic acid poly ethanol copolymer, Merlon, phosphocholine, vinylpyrrolidone copolymer, fluoropolymer, styrene-isobutene .-styrene, polyethylene ethylene acetic acid.
Among the embodiment; Said bonding bottom is through in containing the solution of bonding agent, soaking, dry attached to alloy silk surface with the alloy silk; The thickness of said bonding bottom is 1/5th to 1/3rd of coating layer thickness, and said medicine layer is that the mode through ultrasonic atomization is coated on the bonding bottom.
Among the embodiment, the alloy wire ring that the said face of cylinder distributes and the spacing 11-3 of alloy wire ring are 20 microns to 50 microns, and the best is 30 microns.
Among the embodiment, said alloy silk is titanium magnesium alloy silk or cochrome silk.
Like Fig. 5 and shown in Figure 6; A kind of Lai Mushi pipe (Schlemm) expandable stent assembly of executing; Comprise a face of cylinder hollow housing support and a support pushing body 18; The said face of cylinder be by behind crooked 360 degree of alloy silk circular arc then inflection more crooked 360 degree of circular arc form successive circular curve circle and constitute, it is the expand end of diameter greater than the alloy filament diameter that said alloy silk has an end at least; In the present embodiment; Said support pushing body is a cylinder; A cylindrical end is conical head 18-1, and the cylindrical other end is provided with the baffle ring 18-2 of projection, and the diameter of baffle ring is greater than 20 microns of face of cylinder hollow housing stent diameters; On the outer face of baffle ring, be provided with the protruding 18-3 that connects rope yarn, face of cylinder hollow housing is inserted in cylinder and forms support assembly until pushing up baffle ring.Lai Mushi pipe (Schlemm) expandable stent is executed in the very convenient placement of this kind assembly; And after placement, be easy to the support pushing body is taken out; Described support pushing body can use and gather tetrafluoro rod processing and fabricating; Under very little diameter, gather tetrafluoro rod good toughness but also have extraordinary flexibility.
Referring to Fig. 7 and Fig. 8; In the present embodiment, said support pushing body is a cylindrical casing 19, and the end sealing of cylindrical casing is provided with the protruding 19-1 that connects rope yarn on Closed End, and face of cylinder hollow housing inserts cylindrical casing and forms support assembly.Lai Mushi pipe (Schlemm) expandable stent is executed in the also very convenient placement of this kind assembly; Conical head is implanted during placement at present; And after placement, catch the rope yarn that is connected cylindrical sleeve to be easy to the support pushing body is taken out; Described support pushing body can use and gather tetrafluoro rod processing and fabricating, under very little diameter, gathers tetrafluoro rod good toughness but also has extraordinary flexibility.
The use of the foregoing description such as Fig. 9 and shown in Figure 10; Before the operation; Be ready to be provided with conical head 18-1 the support pushing body, execute Lai Mushi pipe (Schlemm) expandable stent 14 execute the combination of Lai Mushi pipe (Schlemm) expandable stent, prolene suture 13 and elasticity microtubular; The elasticity microtubular is made up of polypropylene material, and end expands, and can be used for fixing traction sutures.Microtubular diameter 100um; Length is 10cm; Mainly act as: microtubular earlier gets into and executes Lai Mushi pipe (Schlemm) chamber through executing Lai Mushi pipe (Schlemm) chamber broken ends of fractured bone, thereby carries out predilation and (promptly get into from the broken ends of fractured bone of executing Lai Mushi pipe (Schlemm) chamber, after executing Lai Mushi pipe (Schlemm) chamber 360 degree executing Lai Mushi pipe (Schlemm) chamber; Pass from the same broken ends of fractured bone); To execute the terminal suture of Lai Mushi pipe (Schlemm) expandable stent then and expand terminal linking to each other, oppositely extract microtubular out, and will execute Lai Mushi pipe (Schlemm) expandable stent and bring the correct position of executing Lai Mushi pipe (Schlemm) chamber into microtubular.
When [0040] performing the operation, with 2% lignocaine+0.75% bupivacaine equivalent ball week anesthesia.Doing the top is the substrate conjunctival flap with the fornices.Do 1/ 3 thick, 5.0 * 5.5 mm size limbus of corneae substrate shallow-layer scleral flap.Leading edge reaches 1mm in the transparency cornea, makes the trapezoidal Deep Layer of Sclera lobe of 3.5 * 4.0mm, and thickness reaches and can see the black tunica uvea thoroughly by the sclera bed.Cross scleral spur concentric circular fiber; Cut open and execute Lai Mushi pipe (Schlemm); The wall of regarding sb. as an outsider separates suddenly, continues to be separated to 0.5 mm in the transparency cornea forward on the posterior elastic membrane surface, wipes out the Deep Layer of Sclera lobe; Remove and execute Lai Mushi pipe (Schlemm) inwall and adjacent tubing, aqueous humor slowly oozes out.Do the long radial incision of 2mm at the trailing edge of the excessive band of corneoscleral junction, successively deepen, until seeing that limpid aqueous humor flows out from otch sidewall one pore, be that executing Lai Mushi manages (Schlemm) broken ends of fractured bone here.Lai Mushi pipe (Schlemm) 16 broken ends of fractured bone are executed in the head end insertion of elasticity microtubular 15; Injecting viscoelastic agent simultaneously; Get into from an end and to execute Lai Mushi pipe (Schlemm), when elasticity microtubular head end around executing Lai Mushi pipe (Schlemm) week when the other end passes, an end that will pass the said Lai Mushi of executing pipe (Schlemm) expandable stent suture is fastened at the elasticity microtubular and is expanded head end 15-1; Along with the elasticity microtubular oppositely withdraws from when executing Lai Mushi pipe (Schlemm); Execute in the Lai Mushi pipe (Schlemm) fastening to bring at the suture of elasticity microtubular head end, this suture hauls conical head, conical head is being pushed away execute Lai Mushi pipe (Schlemm) enlargement of pipe support that it is inserted and executes in Lai Mushi pipe (Schlemm) chamber; When all withdrawing from, the elasticity microtubular executes Lai Mushi pipe (Schlemm); And when executing Lai Mushi pipe (Schlemm) expandable stent and arriving the precalculated position, haul the vertical suture of taper dop and conical head is pulled out execute Lai Mushi pipe (Schlemm), the terminal slip-knot of making a call to of suture; Be embedded in Deep Layer of Sclera lobe below, sew up airtight scleral flap at last.Perhaps work as patient's appearance to executing the unconformable symptom of Lai Mushi pipe (Schlemm) expandable stent when patient's intraocular pressure situation is stable.Can do the top again is the substrate conjunctival flap with the fornices, opens shallow-layer and Deep Layer of Sclera lobe, searches out scleral flap below slip-knot, holds the draught line 17 of executing Lai Mushi pipe (Schlemm) expandable stent, it is pulled out execute Lai Mushi pipe (Schlemm) chamber.
Claims (10)
1. execute Lai Mushi pipe (Schlemm) expandable stent for one kind; It is characterized in that: said expandable stent is the hollow housing of the face of cylinder or drum type face; Said housing is provided with passage; The overall diameter of housing is 0.2MM to 0.5MM, and shell length is 0.5MM to 4MM, and the wall thickness of housing is 0.04MM to 0.06MM.
2. Lai Mushi pipe (Schlemm) expandable stent of executing according to claim 1; It is characterized in that: said housing is through circumferential skewing, the axial formed curve of inflection constitute the face of cylinder or drum type face repeatedly by tinsel; The curve of the said formation face of cylinder or drum type face is by co-axial alternate and right-handed screw ring and backpitch ring that put constitute; The lineal measure of the lineal measure of said right-handed screw ring and said backpitch ring is greater than said face of cylinder girth and less than two times of said face of cylinder girth; One end of the said right-handed screw ring that each is adjacent and the other end of said backpitch ring constitute one and flow back to folded tooth; The other end of the said right-handed screw ring that each is adjacent and an end of said backpitch ring constitute another and flow back to folded tooth, said one flow back to folded tooth crown and the said crown that another flows back to folded tooth in opposite directions, whenever flow back to and constitute teeth groove between the folded tooth; One of which row's inflection tooth and the teeth groove and inflection tooth each other corresponding also mutual embedding of teeth groove with another row, the smooth circle in the two ends of said cylinder sigmoid curves is blunt.
3. Lai Mushi pipe (Schlemm) expandable stent of executing according to claim 1; It is characterized in that: said housing is a RF, and this RF comprises a plurality of wavy annular supporting constructions unit; The annular supports construction unit is arranged in regular turn; Each is arranged between the corresponding crest of annular supports construction unit and is close, each arrange between the corresponding trough of annular supports construction unit away from, between the crest that is close through the rod member connection.
4. execute Lai Mushi pipe (Schlemm) expandable stent for one kind; It is characterized in that: said expandable stent is a face of cylinder hollow housing; The said face of cylinder is to form successive circular curve circle by crooked 360 degree backs of an alloy silk circular arc and then crooked 360 degree of inflection circular arc to constitute; It is the expand end of diameter greater than the alloy filament diameter that said alloy silk has an end at least; Said alloy silk surface has and is coated with 10 microns coatings to 50 micron thick; Said coating comprises bonding bottom and medicine layer, and said medicine layer is that mitomycin, heparin mix, a kind of in the rapamycin, paclitaxel, polylactic acid poly ethanol copolymer, Merlon, phosphocholine, vinylpyrrolidone copolymer, fluoropolymer, styrene-isobutene .-styrene, polyethylene ethylene acetic acid.
5. a kind of Lai Mushi pipe (Schlemm) expandable stent of executing according to claim 4; It is characterized in that: said bonding bottom is through in containing the solution of bonding agent, soaking, dry attached to alloy silk surface with the alloy silk; The thickness of said bonding bottom is 1/5th to 1/3rd of coating layer thickness, and said medicine layer is that the mode through ultrasonic atomization is coated on the bonding bottom.
6. a kind of Lai Mushi pipe (Schlemm) expandable stent of executing according to claim 4, it is characterized in that: the alloy wire ring that the said face of cylinder distributes and the spacing of alloy wire ring are 20 microns to 50 microns.
7. a kind of Lai Mushi pipe (Schlemm) expandable stent of executing according to claim 4, it is characterized in that: said alloy silk is titanium magnesium alloy silk or cochrome silk.
8. execute Lai Mushi pipe (Schlemm) expandable stent assembly for one kind; It is characterized in that: said assembly comprises a face of cylinder hollow housing support and a support pushing body; The said face of cylinder is to form successive circular curve circle by crooked 360 degree backs of an alloy silk circular arc and then crooked 360 degree of inflection circular arc to constitute; It is the expand end of diameter greater than the alloy filament diameter that said alloy silk has an end at least, and said support pushing body is held face of cylinder hollow housing support.
9. a kind of Lai Mushi pipe (Schlemm) expandable stent assembly of executing according to claim 8; It is characterized in that: said support pushing body is a cylinder; A cylindrical end is a conical head, and the cylindrical other end is provided with the baffle ring of projection, and the diameter of baffle ring is greater than 20 microns of face of cylinder hollow housing stent diameters; On the outer face of baffle ring, be provided with the convexity that connects rope yarn, face of cylinder hollow housing is inserted in cylinder until pushing up baffle ring.
10. a kind of Lai Mushi pipe (Schlemm) expandable stent assembly of executing according to claim 8; It is characterized in that: said support pushing body is a cylindrical casing; The one end sealing of cylindrical casing; On Closed End, be provided with the convexity that connects suture, face of cylinder hollow housing inserts cylindrical casing.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210198446.0A CN102824238B (en) | 2011-06-16 | 2012-06-16 | Schlemm tube expansion bracket and combined body thereof |
| CN201410141744.5A CN103932841B (en) | 2011-06-16 | 2012-06-16 | One is executed Lai Mushi and is managed (Schlemm) expandable stent and assembly thereof |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110162424.4 | 2011-06-16 | ||
| CN201110162424 | 2011-06-16 | ||
| CN201210198446.0A CN102824238B (en) | 2011-06-16 | 2012-06-16 | Schlemm tube expansion bracket and combined body thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410141744.5A Division CN103932841B (en) | 2011-06-16 | 2012-06-16 | One is executed Lai Mushi and is managed (Schlemm) expandable stent and assembly thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102824238A true CN102824238A (en) | 2012-12-19 |
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| CN201210198446.0A Active CN102824238B (en) | 2011-06-16 | 2012-06-16 | Schlemm tube expansion bracket and combined body thereof |
| CN201410141744.5A Active CN103932841B (en) | 2011-06-16 | 2012-06-16 | One is executed Lai Mushi and is managed (Schlemm) expandable stent and assembly thereof |
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| CN201410141744.5A Active CN103932841B (en) | 2011-06-16 | 2012-06-16 | One is executed Lai Mushi and is managed (Schlemm) expandable stent and assembly thereof |
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| CN106214295A (en) * | 2016-01-20 | 2016-12-14 | 沈晨阳 | A kind of it is applicable to the arterial vascular Biodegradable vascular scaffold with tapering |
| CN105726203A (en) * | 2016-02-04 | 2016-07-06 | 张绍丹 | Schlemm tube probing and flushing support sleeve and use method thereof |
| WO2018121340A1 (en) * | 2016-12-31 | 2018-07-05 | 先健科技(深圳)有限公司 | Absorbable stent |
| CN108969800A (en) * | 2017-06-05 | 2018-12-11 | 上海交通大学 | The preparation method of Wholly-degradable magnesium alloy bracket drug-carried coat with protective layer |
| CN114555019A (en) * | 2019-07-22 | 2022-05-27 | 安特雷克公司 | Method and apparatus for increasing aqueous drainage of the eye |
| CN110744763A (en) * | 2019-09-23 | 2020-02-04 | 铜仁学院 | Nano biomedical product preparation system and method |
| WO2021150962A1 (en) * | 2020-01-24 | 2021-07-29 | W. L. Gore & Associates, Inc. | Sustained-release matrices for adventitial or periadventitial neural ablation and uses thereof |
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| CN113367885A (en) * | 2020-03-10 | 2021-09-10 | 成都普道尔生物科技有限公司 | Glaucoma drainage tube, material thereof and implantation device |
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| CN103932841B (en) | 2015-08-12 |
| CN102824238B (en) | 2014-07-09 |
| CN103932841A (en) | 2014-07-23 |
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Effective date of registration: 20220708 Address after: 1 dongjiaomin lane, Dongcheng District, Beijing Patentee after: BEIJING TONGREN HOSPITAL, CAPITAL MEDICAL University Address before: 100730 No. 1 East Lane, Beijing, Dongcheng District Patentee before: Wang Ningli |