CN102813902A - Drug for treating stomach and intestine diseases and method for preparing drug for treating stomach and intestine disease - Google Patents

Drug for treating stomach and intestine diseases and method for preparing drug for treating stomach and intestine disease Download PDF

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CN102813902A
CN102813902A CN2012103193581A CN201210319358A CN102813902A CN 102813902 A CN102813902 A CN 102813902A CN 2012103193581 A CN2012103193581 A CN 2012103193581A CN 201210319358 A CN201210319358 A CN 201210319358A CN 102813902 A CN102813902 A CN 102813902A
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李大坤
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Abstract

The invention relates to a drug for treating stomach and intestine diseases and a method for preparing the drug for treating stomach and intestine diseases, wherein the drug is specifically a Chinese herbal drug which is prepared from radix bupleuri, agilawood, hippophae rhamnoides, pawpaw, endothelium corneum gigeriae galli, pepper, codonopsis pilosula, cinnamon, liquorice, dried ginger, Chinese angelica, divine comedy and other Chinese herbal medicines. The drug is prepared finely from the pure Chinese herbal medicines, and has the good functions of regulating a balance of yin and yang, tonifying spleen, warming stomach, nourishing liver, tonifying kidney, relieving spasm, regulating vital energy, dispelling melancholy, removing coldness, expelling toxin, making acid, resisting gastric ulcer, enhancing gastric motility, aiding digestion, stopping bleeding, preventing vomiting, curing diarrhea and abirritating. A patient does not need to avoid certain food when taking the drug for treating stomach and intestine diseases, so the nutrition of the patient is balanced, the treatment and health are benefited, and the drug can treat both stomach and intestine diseases.

Description

A kind of medicine of treating gastroenteropathy and preparation method thereof
Technical field
The present invention relates to a kind of medicine of treating gastroenteropathy, specifically is the Chinese medicine medicine of former section preparation with Chinese herbal medicine.
Background technology
Gastroenteropathy is commonly encountered diseases, a frequently-occurring disease clinically; The pathogeny more complicated; Because the type of morbidity is different separately, common clinically gastropathy has acute gastritis, chronic gastritis, superficial gastritis, atrophic gastritis, gastric ulcer, peptic ulcer, stomach neurosis, gastroptosis, duodenal ulcer, gastric cancer or the like.The morbidity in youth, middle-aged population of gastric ulcer and superficial gastritis is commonplace, and atrophic gastritis, gastric ulcer are again the precancerous lesions of gastric cancer; Gastroptosis is very general in driver's occupation, and other various gastropathy are fallen ill also a lot in old, young crowd, and clinical symptoms mainly shows as in gastralgia, acid regurgitation, dyspepsia or the like.The staff that several kinds of industries are arranged in population of China, the gastropathy sickness rate is very high: like driver, field man, purchasing agent etc.; Also has the part crowd, because of disorderly (excessively) causes gastrointestinal function not normal with prescription drugs, crapulence, gluttony, nervous etc.
At present, both at home and abroad to the Drug therapy of gastroenteropathy, exist following not enough: treat single; The medicine of treatment gastropathy can not be treated intestinal tract disease, and the medicine of treatment intestinal tract disease can not be treated gastropathy, also need aviod certain food during the treatment; Therefore; Cause patient's nutritional imbalance, be unfavorable for treatment, be unfavorable for health.
Summary of the invention
The object of the present invention is to provide during a kind of treatment gastroenteropathy need not dieting, gastropathy, intestinal tract disease is double controls, and can treat the medicine that gastroenteropathy again can analgesic treatment gastroenteropathy.
Another object of the present invention is to provide manufacturing method for above mentioned medicine.
Solution of the present invention derives from stone bridge town, Xiangyang county Tian Shi family; It is the sick century-old ancient prescription (mainly treating the cholera disease period) of treatment cholera in the Qing Dynasty; The applicant in conjunction with the utilization practice in over one hundred year, improves research and development with reference to modern pharmacology achievement in research and pathological principle.
In the present invention, except that other explanations were arranged, the ratio that is adopted was weight ratio.
Medicine of the present invention is to process (consumption is a weight portion) by following component
Radix Bupleuri 5-35 part Lignum Aquilariae Resinatum 5-35 part Fructus Hippophae 5-35 part
Fructus Chaenomelis 5-35 part Endothelium Corneum Gigeriae Galli 5-35 part Pericarpium Zanthoxyli 5-35 part
Radix Codonopsis 5-35 part Cortex Cinnamomi 5-35 part Radix Glycyrrhizae 5-35 part
Rhizoma Zingiberis 5-35 part Radix Angelicae Sinensis 5-35 part Massa Medicata Fermentata 5-35 part.
The formula optimization weight proportion scope of preparation medicine of the present invention is:
Radix Bupleuri 10-35 part Lignum Aquilariae Resinatum 15-35 part Fructus Hippophae 15-35 part
Fructus Chaenomelis 10-35 part Endothelium Corneum Gigeriae Galli 15-35 part Pericarpium Zanthoxyli 5-35 part
Radix Codonopsis 5-35 part Cortex Cinnamomi 5-35 part Radix Glycyrrhizae 5-35 part
Rhizoma Zingiberis 5-35 part Radix Angelicae Sinensis 5-35 part Massa Medicata Fermentata 10-35 part.
The optimum weight proportioning of medicine of the present invention is:
15 parts of 25 portions of Fructus Hippophaes of 15 portions of Lignum Aquilariae Resinatum of Radix Bupleuri
5 parts in 15 portions of Pericarpium Zanthoxylies of 15 parts of Endothelium Corneum Gigeriae Galli of Fructus Chaenomelis
5 parts in 5 portions of Radix Glycyrrhizaes of 10 portions of Cortex Cinnamomis of Radix Codonopsis
15 parts of 5 parts of Massa Medicata Fermentata of 5 parts of Radix Angelicae Sinensis of Rhizoma Zingiberis.
Said Massa Medicata Fermentata is Massa Medicata Fermentata again.
Above-mentioned each component is processed production of medicine method of the present invention is:
1, earlier Radix Codonopsis, Pericarpium Zanthoxyli are distinguished parching to brown with low baking temperature; 2, the extracting liquorice sheet is fried with low baking temperature and is done; 3, Radix Bupleuri is fried with rice vinegar and is done (rice vinegar: Radix Bupleuri weight ratio 1:7-20); 4, Lignum Aquilariae Resinatum, Fructus Hippophae, Massa Medicata Fermentata, Cortex Cinnamomi, Radix Angelicae Sinensis, Rhizoma Zingiberis, Endothelium Corneum Gigeriae Galli, Fructus Chaenomelis and said medicine are crushed to 120 order fine powders; 5, the above-mentioned fine powder that mixes is incubated 10 minutes down at 110 ℃, and then 20 minutes sterilizings of 100-105 ℃ of maintenance of cooling, powder processed.
Above-mentioned powder can be processed on solid block dosage form, pill, tablet, electuary and any pharmaceutics dosage form.To satisfy different patients' needs.
Clinical drug of the present invention uses the result to show.
1, the present invention adopts pure purification of tcm to form, and each component all meets the regulation of doctor's politics and law rule, and it is to utilize the comprehensive function of the Chinese herbal medicine of respectively distinguishing the flavor of to cure the disease, and does not contain chemicals, and is harmless to human non-toxic.Need not decoct, not have obvious bitterness sense, certain nutrition is arranged, taking convenience meets the state food safety law.
2, have good adjusting equilibrium between yin and yang, spleen invigorating, stomach warming, nourishing the liver, the kidney invigorating, spasmolytic, regulate the flow of vital energy, resolving depression, cold expelling, toxin expelling, antacid, anti-gastric-ulcer, strengthen gastric motility, aid digestion, hemostasis, preventing or arresting vomiting, antidiarrheal and analgesic activity.
3, dysentery, acute diarrhea patient per hour take a ball with salt water, and recovery from illness in 4 hours needn't be infused.
4, analgesia is equivalent to tramadol hydrochloride injection; Gastric hemorrhage obviously is superior to YUNNAN BAIYAO.
5, treating different diseases with the same therapeutic principle: the pure Chinese herbal medicine of this side, integration of edible and medicinal herbs, all-ages, take medicine of the present invention for the patient that gastroenteropathy is arranged and can cure the disease, the patient of no gastroenteropathy takes medicine of the present invention and can keep healthy.1 of middle-aged and elderly people every day help health, and the effect of YIN nourishing and YANG strengthening is arranged; Existing clinical practice proof the present invention (Rong Kun belalumas) have relieving spasm to stop pain, antidiarrheal, hemostasis, preventing or arresting vomiting rapidly, wide, the instant effect of treatment, can replace the effect of multiple medicine, have no side effect, esophagitis, gastroenteropathy are all had specially good effect; Particularly treat the patient of gastrorrhagia, separated muscular spasm, drunk, glutton has the effect of getting instant result after the use; This medicine can be treated diarrhoea, dysentery and treated constipation again.
The present invention is owing to need not aviod certain food during the treatment gastroenteropathy, and nutrition ability balance helps treatment like this, helps health.Whole world medicine person generally acknowledges, the not pain relieving of medicine of curing the disease, and the analgesic medicine is not cured the disease, and this law has been broken by the present invention, and this medicine is that pain relieving is cured the disease again.
For showing the therapeutic effect of medicine of the present invention to gastroenteropathy; Since 1992; The present invention's (clinical title Rong Kun belalumas or Rong Kun belalumas honeyed pill, stomach relax ball, belalumas, belalumas ball) is through system's clinical observation for many years, treatment patient hundreds of thousands person-time, and effective percentage is more than 90%.It is clinical to have finished first phase, and effective percentage is more than 98%, and cure rate is more than 95%; Drug effect (animal) result of the test is: anti-gastric-ulcer is 1.5 times of cimetidine; Antidiarrheal obviously is superior to the hydrochloric acid berberine; Gastric motility obviously is superior to domperidone tablet (motilium).Clinical practice proves: patient's " food stagnation, drunk " clinical comparison, effect of the present invention obviously is superior to the effect of JIANWEI XIAOSHI PIAN.Acute toxicity (animal) result of the test is: give 20 white mice high capacity perfusion 7 days by the dosage of 43.2 gram/kilograms (be equivalent to be grown up dosage 100 times), white mice all survives as a result, and body weight increases to some extent, all through testing.
It is following that existing selection record case 314 examples complete, that can supply analyze are carried out efficacy analysis:
Pharmacological effect and toxicity test result:
Check-up through statistical means, X 2=5.07, p<0.05, two groups of significant differences of men and women.
Check-up through statistical means, X 2=23.883, p<0.01, difference is extremely remarkable
Right, including dysentery, including a variety of gastrointestinal diseases have more than 90% efficacy against other diseases associated with gastrointestinal symptom control more than 85% rate of Ti.
Figure 356541DEST_PATH_IMAGE003
☆ complication: refer to the symptom of digestive tract that acute, chronic hepatitis, liver cirrhosis, cholelithiasis and other diseases cause.
Figure 155869DEST_PATH_IMAGE004
Check-up through statistical means, X 2=16.46, p<0.01, difference is meaning extremely significantly.
The present invention treats the hundreds of thousands patient, analyzes so that more complete medical history record 314 examples to be arranged, and wherein cures 299 examples, cure rate 95.2%, effective 310 examples, effective percentage 98.7%.Women's cure rate is 96.6%, a little more than male 94.2%, possibly live life bad and practises with the male and pass through, and is relevant like, smoking, excessive drinking, erratic diet.Suffer from diseases (more than 90%) such as acute gastroenteritis, dyspepsia because of treatment child polyphyly, child's cure rate is up to 100%.Find also in the investigation and interview that " Rong Kun belalumas " has unique therapeutic effect to the dyspepsia of child below 8 years old, diarrhoea, stomachache, nausea and vomiting etc.; It is poor that good year group is organized than younger ones in an age group; Main cause maybe be because patient's sick time be long, and stomach intestinal tissue's infringement is heavier.
Because to gastrointestinal mucosal, especially gastric mucosa has powerful protection and promotes the healing effect, the present invention is to acute or chronic gastritis, gastric and duodenal ulcers, and acute chronic enteritis is good, and cure rate is more than 90%.It has fabulous curative effect to acute enteritis, and obviously former to be used to treat the cholera disease relevant with " Rong Kun belalumas " ancient prescription; The multiple digestive tract complication that gastroptosis and various diseases are occurred together also has obvious therapeutic effect or mitigation like stomachache, gastrorrhagia, diarrhoea, nausea and vomiting, singultus and gastric perforation of being suitable for expectant treatment etc.; Acute, chronic hepatitis early stage liver cirrhosis etc. there is the auxiliary treatment effect.The chronic colitis therapeutic effect is compared and will be differed from; And when being used to treat gastroptosis; As the effect that do not have additional nutrients simultaneously then also can variation, and in addition, also observe a kind of special efficacy of " Rong Kun belalumas ": the cancer patient implements in the chemotherapy process; Taking this medicine has the effect of obvious protection gastrointestinal granulosa, and the gastrointestinal side effect that chemotherapeutics is caused disappears.
The specific embodiment
Embodiment 1:
Take by weighing raw material (weight portion) by following proportioning
15 parts of 25 portions of Fructus Hippophaes of 25 portions of Lignum Aquilariae Resinatum of Radix Bupleuri
5 parts in 10 portions of Pericarpium Zanthoxylies of 25 parts of Endothelium Corneum Gigeriae Galli of Fructus Chaenomelis
5 parts in 10 portions of Radix Glycyrrhizaes of 15 portions of Cortex Cinnamomis of Radix Codonopsis
10 parts of 8 parts of Massa Medicata Fermentata of 5 parts of Radix Angelicae Sinensis of Rhizoma Zingiberis.
Earlier Radix Codonopsis, Pericarpium Zanthoxyli are distinguished parching to brown with low baking temperature; Extracting liquorice is fried with low baking temperature and is done; Radix Bupleuri is fried with rice vinegar and is done (rice vinegar: the Radix Bupleuri weight ratio is 1:7-20); Medicines such as Lignum Aquilariae Resinatum, Fructus Hippophae, Massa Medicata Fermentata, Cortex Cinnamomi, Radix Angelicae Sinensis, Rhizoma Zingiberis, Endothelium Corneum Gigeriae Galli, Fructus Chaenomelis and above-mentioned Radix Codonopsis, Pericarpium Zanthoxyli, Radix Glycyrrhizae, Radix Bupleuri are crushed to 120 order fine powders; The above-mentioned fine powder that mixes is incubated 10 minutes down at 110 ℃, and then 20 minutes sterilizings of 100-105 ℃ of maintenance of cooling, powder processed.
Embodiment 2: take by weighing raw material (weight portion) by following proportioning
15 parts of 25 portions of Fructus Hippophaes of 20 portions of Lignum Aquilariae Resinatum of Radix Bupleuri
5 parts in 10 portions of Pericarpium Zanthoxylies of 20 parts of Endothelium Corneum Gigeriae Galli of Fructus Chaenomelis
5 parts in 6 portions of Radix Glycyrrhizaes of 5 portions of Cortex Cinnamomis of Radix Codonopsis
10 parts of 8 parts of Massa Medicata Fermentata of 5 parts of Radix Angelicae Sinensis of Rhizoma Zingiberis.
Embodiment 3: take by weighing raw material (weight portion) by following proportioning
15 parts of 25 portions of Fructus Hippophaes of 15 portions of Lignum Aquilariae Resinatum of Radix Bupleuri
5 parts in 10 portions of Pericarpium Zanthoxylies of 10 parts of Endothelium Corneum Gigeriae Galli of Fructus Chaenomelis
5 parts in 6 portions of Radix Glycyrrhizaes of 5 portions of Cortex Cinnamomis of Radix Codonopsis
8 parts of 8 parts of Massa Medicata Fermentata of 5 parts of Radix Angelicae Sinensis of Rhizoma Zingiberis.
Embodiment 4: take by weighing raw material (weight portion) by following proportioning
15 parts of 20 portions of Fructus Hippophaes of 15 portions of Lignum Aquilariae Resinatum of Radix Bupleuri
5 parts in 10 portions of Pericarpium Zanthoxylies of 8 parts of Endothelium Corneum Gigeriae Galli of Fructus Chaenomelis
5 parts in 4 portions of Radix Glycyrrhizaes of 3 portions of Cortex Cinnamomis of Radix Codonopsis
8 parts of 5 parts of Massa Medicata Fermentata of 5 parts of Radix Angelicae Sinensis of Rhizoma Zingiberis.
Embodiment 5: take by weighing raw material (weight portion) by following proportioning
13 parts of 10 portions of Fructus Hippophaes of 10 portions of Lignum Aquilariae Resinatum of Radix Bupleuri
5 parts in 8 portions of Pericarpium Zanthoxylies of 8 parts of Endothelium Corneum Gigeriae Galli of Fructus Chaenomelis
5 parts in 4 portions of Radix Glycyrrhizaes of 3 portions of Cortex Cinnamomis of Radix Codonopsis
8 parts of 5 parts of Massa Medicata Fermentata of 5 parts of Radix Angelicae Sinensis of Rhizoma Zingiberis.
Embodiment 6: take by weighing raw material (weight portion) by following proportioning
8 parts of 10 portions of Fructus Hippophaes of 10 portions of Lignum Aquilariae Resinatum of Radix Bupleuri
5 parts in 8 portions of Pericarpium Zanthoxylies of 5 parts of Endothelium Corneum Gigeriae Galli of Fructus Chaenomelis
5 parts in 4 portions of Radix Glycyrrhizaes of 3 portions of Cortex Cinnamomis of Radix Codonopsis
5 parts of 3 parts of Massa Medicata Fermentata of 2 parts of Radix Angelicae Sinensis of Rhizoma Zingiberis.
Production method is following:
Earlier Radix Codonopsis, Pericarpium Zanthoxyli are distinguished parching to brown with low baking temperature; 2, the extracting liquorice sheet is fried with low baking temperature and is done; 3, Radix Bupleuri is fried with rice vinegar and is done (rice vinegar: Radix Bupleuri weight ratio 1:7-20); 4, Lignum Aquilariae Resinatum, Fructus Hippophae, Massa Medicata Fermentata, Cortex Cinnamomi, Radix Angelicae Sinensis, Rhizoma Zingiberis, Endothelium Corneum Gigeriae Galli, Fructus Chaenomelis and said medicine are crushed to 120 order fine powders; 5, the above-mentioned fine powder that mixes is incubated 10 minutes down at 110 ℃, and then cooling kept 20 minutes for 100-105 ℃.

Claims (6)

1. medicine of treating gastroenteropathy, it is characterized in that: it is the medicament of being processed by the following weight proportion raw material:
Radix Bupleuri 5-35 part Lignum Aquilariae Resinatum 5-35 part Fructus Hippophae 5-35 part
Fructus Chaenomelis 5-35 part Endothelium Corneum Gigeriae Galli 5-35 part Pericarpium Zanthoxyli 5-35 part
Radix Codonopsis 5-35 part Cortex Cinnamomi 5-35 part Radix Glycyrrhizae 5-35 part
Rhizoma Zingiberis 5-35 part Radix Angelicae Sinensis 5-35 part Massa Medicata Fermentata 5-35 part.
2. the medicine of treatment gastroenteropathy according to claim 1, wherein the weight proportion of each raw material is:
Radix Bupleuri 10-35 part Lignum Aquilariae Resinatum 15-35 part Fructus Hippophae 15-35 part
Fructus Chaenomelis 10-35 part Endothelium Corneum Gigeriae Galli 15-35 part Pericarpium Zanthoxyli 5-35 part
Radix Codonopsis 5-35 part Cortex Cinnamomi 5-35 part Radix Glycyrrhizae 5-35 part
Rhizoma Zingiberis 5-35 part Radix Angelicae Sinensis 5-35 part Massa Medicata Fermentata 10-35 part.
3. the medicine of treatment gastroenteropathy according to claim 1, wherein the weight proportion of each raw material is:
15 parts of 25 portions of Fructus Hippophaes of 15 portions of Lignum Aquilariae Resinatum of Radix Bupleuri
5 parts in 15 portions of Pericarpium Zanthoxylies of 15 parts of Endothelium Corneum Gigeriae Galli of Fructus Chaenomelis
5 parts in 5 portions of Radix Glycyrrhizaes of 10 portions of Cortex Cinnamomis of Radix Codonopsis
15 parts of 5 parts of Massa Medicata Fermentata of 5 parts of Radix Angelicae Sinensis of Rhizoma Zingiberis.
4. according to the medicine of claim 1,2 or 3 described treatment gastroenteropathys, the said medicament of its characteristic is a said dosage form on any pharmaceutics.
5. the medicine of treatment gastroenteropathy according to claim 4 is characterized in that said medicament is powder, piece agent or honeyed pill.
6. the method for preparing of the medicine of the said treatment gastroenteropathy of claim 5 is characterized in that: earlier Radix Codonopsis, Pericarpium Zanthoxyli are distinguished parching to brown with low baking temperature; Extracting liquorice is fried with low baking temperature and is done; Radix Bupleuri is fried with rice vinegar and is done, and rice vinegar: the Radix Bupleuri weight ratio is 1:7-20; Medicines such as Lignum Aquilariae Resinatum, Fructus Hippophae, Massa Medicata Fermentata, Cortex Cinnamomi, Radix Angelicae Sinensis, Rhizoma Zingiberis, Endothelium Corneum Gigeriae Galli, Fructus Chaenomelis and above-mentioned Radix Codonopsis, Pericarpium Zanthoxyli, Radix Glycyrrhizae, Radix Bupleuri are crushed to 120 order fine powders; The above-mentioned fine powder that mixes is incubated 10 minutes down at 110 ℃, and then 20 minutes sterilizings of 100-105 ℃ of maintenance of cooling, powder processed.
CN2012103193581A 2012-09-03 2012-09-03 Drug for treating stomach and intestine diseases and method for preparing drug for treating stomach and intestine disease Pending CN102813902A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103405701A (en) * 2012-09-03 2013-11-27 李大坤 Medicine for treating gastrointestinal diseases and preparation method thereof
CN105233239A (en) * 2015-11-20 2016-01-13 门源县雪草木生物药业有限公司 Application of medicine composition to preparation of medicine for treating gastric ulcer
CN112472754A (en) * 2019-09-11 2021-03-12 潘秀刚 Medicine for treating gastrointestinal diseases in digestive system department

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104491793A (en) * 2014-12-13 2015-04-08 李洋 Traditional Chinese medicine composition for treating dysentery, preparation method and application
CN104491809A (en) * 2014-12-23 2015-04-08 陈晨 Traditional Chinese medicine for treating gastrointestinal complications
CN114159392A (en) * 2021-12-08 2022-03-11 冯兴奎 Traditional Chinese medicine powder for treating gastroenteritis

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CN1282610A (en) * 1999-07-30 2001-02-07 李大坤 Medicine for treating gastrointestinal tract diseases and preparation method thereof
CN101703734A (en) * 2009-09-24 2010-05-12 苟于洋 Chinese medicinal preparation for treating gastrosis

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CN102793907B (en) * 2012-09-03 2013-09-18 李大坤 Medicament for treating oral ulcer (decay) and preparation method thereof
CN102813902A (en) * 2012-09-03 2012-12-12 李大坤 Drug for treating stomach and intestine diseases and method for preparing drug for treating stomach and intestine disease

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CN1178108A (en) * 1996-09-28 1998-04-08 郑文学 Weixiandan as medicine for gastropathy
CN1282610A (en) * 1999-07-30 2001-02-07 李大坤 Medicine for treating gastrointestinal tract diseases and preparation method thereof
CN101703734A (en) * 2009-09-24 2010-05-12 苟于洋 Chinese medicinal preparation for treating gastrosis

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103405701A (en) * 2012-09-03 2013-11-27 李大坤 Medicine for treating gastrointestinal diseases and preparation method thereof
CN103405701B (en) * 2012-09-03 2016-12-28 李大坤 A kind of medicine treating gastroenteropathy and preparation method thereof
CN105233239A (en) * 2015-11-20 2016-01-13 门源县雪草木生物药业有限公司 Application of medicine composition to preparation of medicine for treating gastric ulcer
CN112472754A (en) * 2019-09-11 2021-03-12 潘秀刚 Medicine for treating gastrointestinal diseases in digestive system department

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Application publication date: 20121212