CN102805266B - Feed for improving digestive and immunologic ability of chicken - Google Patents
Feed for improving digestive and immunologic ability of chicken Download PDFInfo
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- CN102805266B CN102805266B CN201210297424XA CN201210297424A CN102805266B CN 102805266 B CN102805266 B CN 102805266B CN 201210297424X A CN201210297424X A CN 201210297424XA CN 201210297424 A CN201210297424 A CN 201210297424A CN 102805266 B CN102805266 B CN 102805266B
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Abstract
The invention provides feed for improving the digestive and immunologic ability of chicken, which comprises a feed carrier, choline chloride, lysine hydrochloride, phenylalanine dihydrochloride, pantothenic acid, clostridium butyricum, lactobacillus plantarum, sodium butyrate, stone powder, folic acid, riboflavin, vitamin E, vitamin K, glucolase, amylase, sodium selenate, magnesium sulfate and a Chinese herbal medicine composition additive. The feed has the beneficial effect that a digestion system and an immune system of the chicken can be improved, so that the feeding management and epidemic prevention works during the brooding period are better improved.
Description
Technical field
The present invention relates to technical field of animal, relate in particular to a kind of feed that improves chick digestion and immunocompetence.
Background technology
Chick refers to from going out the chicken of all age grade sections of shell to 7.Whether the health of chick is the basis that ensures the chicken production performance and guarantee the poultry economic benefit.The physiological property of chick has very big difference with becoming chicken, just gone out the young bird of shell because various physiological functions are unsound, the body heat regulation ability is low, have a low resistance, a little less than the digestive function, the stomach and intestine volume is little, and feed intake is limited, a little less than the muscular stomach grainding capacity, the digestive ferment secretion is insufficient, digestion power to nutriment is poor, and the adaptive capacity of environment is poor to external world, and sensitiveness is strong, premunition is poor, encroached on by various pathogenic microorganisms easily, death rate height, these physilogical characteristics have determined to carry out at brood time the importance of feeding and management and epidemic preventing working.
The imperfection that chick digestive system and immune system are grown with and the characteristics of growing, determined the early nutrition feed of chick to have the characteristics with the chicken difference uniqueness of growing up.Be generally the pathogenic microorganism of control chick opening material, add and have the antibiotic composition of immunologic function in feed, this not only is conducive to the absorption of yolk bag, make maternal antibody wherein, nutriment such as cholesterol and polyunsaturated fatty acid can better play a role, can promote digestive system and immune development, reduce the M ﹠ M of chick, but along with resistance strengthens, people have to strengthen the antibiotic using dosage or frequently change antibiotic, Western medicine and the chemicals residual serious contaminated environment in the chick body and influence the healthy of people, so having to seek, people can improve chick digestive system and immune material from Chinese herbal medicine and natural galenical, to replace Western medicine and antibiotic.
Compare with Western medicine, the characteristics of Chinese herbal medicine are natural sex and versatility, and natural sex is from wild or tame kind, are organic matter rather than artificial compound matter; Versatility comprises bidirectional modulation function, anti-microbial effect and the compound action of trophism, immunological enhancement, hormone-like effect, vitaminoid action, " adapting to former " effect, brilliance, in addition, it is secondary with the chemical sproof advantage of low, difficult generation that Chinese herbal medicine has poison, therefore, adopt Chinese herbal medicine to replace Western medicine and antibiotic to improve the emphasis of chick digestive system and the written people's research of immune system.
Summary of the invention
Technical problem to be solved by this invention provides a kind of novel feed that contains the herbal composite additive component, and this feed can improve chick digestive system and immune system, thereby well improves feeding and management and the epidemic preventing working of brood time.
In order to solve the problems of the technologies described above, the invention provides a kind of feed for raising chick immunocompetence, it comprises: feed vector, Choline Chloride, FE-5, phenylalanine hydrochloride, pantothenic acid, clostridium butyricum, Lactobacillus plantarum, sodium butyrate, stone flour, folic acid, riboflavin, vitamin E, vitamin K, glucolase, amylase, sodium selenate, magnesium sulfate and herbal composite additive.
Wherein, with respect to the feed vector of 100 weight portions, other each components contents are Choline Chloride 0.3 ~ 0.7 weight portion in the described feed, FE-5 0.7 ~ 1.3 weight portion, phenylalanine hydrochloride 0.5 ~ 1.0 weight portion, pantothenic acid 0.5 ~ 1.5 weight portion, clostridium butyricum 0.4 ~ 0.8 weight portion, Lactobacillus plantarum 0.6 ~ 1.0 weight portion, sodium butyrate 0.6 ~ 1.2 weight portion, stone flour 2 ~ 4 weight portions, folic acid 0.9 ~ 1.7 weight portion, riboflavin 0.6 ~ 1.2 weight portion, vitamin E 0.9 ~ 1.8 weight portion, vitamin K 0.5 ~ 1.5 weight portion, glucolase 0.4 ~ 0.8 weight portion, amylase 0.6 ~ 1.2 weight portion, sodium selenate 0.2 ~ 0.5 weight portion, magnesium sulfate 0.2 ~ 0.5 weight portion, the Chinese medicine composition content of additive is 8 ~ 10 weight portions.
Wherein, with respect to the feed vector of 100 weight portions, other each components contents are Choline Chloride 0.5 weight portion in the described feed, FE-5 1.1 weight portions, phenylalanine hydrochloride 0.8 weight portion, pantothenic acid 1.1 weight portions, clostridium butyricum 0.6 weight portion, Lactobacillus plantarum 0.8 weight portion, sodium butyrate 1.0 weight portions, stone flour 3 weight portions, folic acid 1.3 weight portions, riboflavin 0.9 weight portion, vitamin e1 .4 weight portion, vitamin K1 .0 weight portion, glucolase 0.6 weight portion, amylase 0.9 weight portion, sodium selenate 0.4 weight portion, magnesium sulfate 0.3 weight portion, the Chinese medicine composition content of additive is 9 weight portions.
Wherein, described herbal composite additive comprises wilsonii, climbing groundsel, gynostemma pentaphylla, giant knotweed, pollen pini, barrenwort, the seed of feather cockscomb, Fructus Hordei Germinatus, betel nut, dried orange peel, Divine Comedy, asafoetide, the Radix Astragali, the bighead atractylodes rhizome, the fruit of glossy privet, bush, Herba Lycopi, the root of herbaceous peony, reticulate millettia and saline cistanche.
In the described herbal composite additive, the weight fraction of each component is than being wilsonii 30 ~ 40 weight portions, climbing groundsel 14 ~ 24 weight portions, gynostemma pentaphylla 16 ~ 26 weight portions, giant knotweed 15 ~ 25 weight portions, pollen pini 24 ~ 34 weight portions, barrenwort 27 ~ 37 weight portions, the seed of feather cockscomb 8 ~ 18 weight portions, Fructus Hordei Germinatus 37 ~ 47 weight portions, betel nut 18 ~ 28 weight portions, dried orange peel 13 ~ 23 weight portions, Divine Comedy 23 ~ 33 weight portions, asafoetide 25 ~ 35 weight portions, the Radix Astragali 67 ~ 77 weight portions, the bighead atractylodes rhizome 49 ~ 59 weight portions, the fruit of glossy privet 43 ~ 53 weight portions, bush 23 ~ 33 weight portions, Herba Lycopi's 18 ~ 28 weight portions, the root of herbaceous peony 25 ~ 35 weight portions, reticulate millettia 26 ~ 36 weight portions and saline cistanche 16 ~ 26 weight portions.
In the described herbal composite additive, the weight fraction of each component is than also can be wilsonii 35 ~ 40 weight portions, climbing groundsel 19 ~ 24 weight portions, gynostemma pentaphylla 21 ~ 26 weight portions, giant knotweed 20 ~ 25 weight portions, pollen pini 29 ~ 34 weight portions, barrenwort 32 ~ 37 weight portions, the seed of feather cockscomb 13 ~ 18 weight portions, Fructus Hordei Germinatus 42 ~ 47 weight portions, betel nut 23 ~ 28 weight portions, dried orange peel 18 ~ 23 weight portions, Divine Comedy 28 ~ 33 weight portions, asafoetide 30 ~ 35 weight portions, the Radix Astragali 72 ~ 77 weight portions, the bighead atractylodes rhizome 54 ~ 59 weight portions, the fruit of glossy privet 48 ~ 53 weight portions, bush 28 ~ 33 weight portions, Herba Lycopi's 23 ~ 28 weight portions, the root of herbaceous peony 30 ~ 35 weight portions, reticulate millettia 31 ~ 36 weight portions and saline cistanche 21 ~ 26 weight portions.
Wherein, described basal feed composition can be one or more mixing in wheat, corn, barley, dregs of beans, peanut meal and the Chinese sorghum, the more preferably mixing of wheat, corn and peanut meal.
The present invention also provides the preparation method of above-mentioned feed, and it comprises:
The first step is ground into 30 orders ~ 50 purpose powder with each component in the feed vector, adds clostridium butyricum and Lactobacillus plantarum subsequently and mixes stirring, and ferment at constant temperature is 15 ~ 20 days under 25 ~ 30 ℃ temperature, obtains the fermented feed carrier;
Second step, each component in the described herbal composite additive is mixed in proportion, add the water with respect to 3 ~ 5 times of mixture qualities subsequently, decocted 2 ~ 4 hours, and filtered, obtain first extract, filter residue adds the water with respect to 1 ~ 3 times of its quality again, decocts 1 ~ 2 hour, filters, obtain second extract, extract is merged, decompression concentrates except anhydrating, obtain dried lotion, adopt the ultra micro flour mill to pulverize, grinding particle size 200 orders ~ 300 orders obtain Powdered Chinese herb feed additive;
In the 3rd step, fermented feed carrier, the Chinese herb feed additive of second step acquisition and other compositions in the described feed that the first step is obtained mix, and obtain mixture, add the water with respect to 3～5 times of mixture qualities, continue to stir 30 minutes ~ 1 hour;
The 4th step, the material that obtains in the 3rd step to be put into the steam modulator under 65 ℃～70 ℃ condition, carry out pre-gelatinization, the gelatinization degree of the feed that obtains is 45～55%;
The 5th step, the material of the 4th pre-gelatinization of step to be carried out steam and boils and push in twin (double) screw extruder, the temperature in the extruder is preferably 100～115 ℃, and pressure is adjusted to 0.5MPa～1.5MPa, is 95～98% until the gelatinization degree of feed;
The 6th step is with the described fodder compound of the dry acquisition of the material that obtains in the 5th step.
Beneficial effect of the present invention:
Feed provided by the invention can improve chick digestive system and immune system, thereby well improves feeding and management and the epidemic preventing working of brood time.
The specific embodiment
The chick growth blastoprolepsis, digestive organs are grown and are relatively lagged behind, and Chinese veterinarian thinks that The spleen and stomach provide the material basis of the acquired, main muscle and four limbs, be source of generating QI and blood, fail the precise and tiny of cloth diet, with nutrition the five internal organs six abdomen four limbs boness of the body collectively, therefore temper is strong transports, then diet multiplication, healthy tendency is from filling nutritional sufficiency, fleshiness is strong, otherwise the contracting of muscle committee, carcass is become thin, therefore, can reach strengthening the spleen and stomach by the Chinese herbal medicine that adds the treatment for relieving indigestion and constipation class among the present invention, digestant effect, the amylase that it is contained, protease etc. can be used as replenishing of the interior digestive ferment of chick body, can strengthen gastral wriggling simultaneously, produce short digestion, by adding the odor type medicinal herb components, fragrant odour can improve the local flavor of feed, stimulates gustatory nerve, reflectivity causes that appetite increases, thereby improves the digestive system of chick.
The traditional Chinese medical science is also thought, be rich in polysaccharide, alkaloid, saponin(e, organic acid, volatilization wet goods bioactivator in the Chinese herbal medicine, all have the effect that strengthens immunity, can promote the immunity of chicken to improve and reparation as the Chinese herbal medicine polysaccharide, the immune stimulatory organ is as growing of spleen, thymus gland, bursa of Fabricius etc.; Improve quantity and the vigor of immunocyte; Strengthen the lymphocytic conversion of T and rate of development; Improve spleen and serum antibody, hemolysin etc., be of value to humoral immunity; The formation of secretion that simultaneously can also the inducing cell factor and T cell, NK cell, complement, by these contained in Chinese herbal medicine immunologic active material activation body immune systems, excite immune response from different links, playing regulates the flow of vital energy helps digestion, invigorating blood circulation what, hemangiectasis, increase CBF, excitor nerve system, promote regeneration of erythrocytes, the effect that improves immunity of organisms.
Based on above-mentioned principle, the present invention adds Chinese herb feed additive in feed, by the wilsonii in the described Chinese herb feed additive, climbing groundsel, gynostemma pentaphylla, giant knotweed, pollen pini, barrenwort, the seed of feather cockscomb, the Radix Astragali, the bighead atractylodes rhizome, the fruit of glossy privet, bush, the Herba Lycopi, the root of herbaceous peony, the synergy of reticulate millettia and saline cistanche, improve the immunity of organisms of chick, improve the immune system of chick, pass through Fructus Hordei Germinatus, betel nut, dried orange peel, Divine Comedy, several compositions of asafoetide this this, strengthen gastral wriggling, produce short digestion, simultaneously, improve the local flavor of feed, stimulate gustatory nerve, reflectivity causes that appetite increases, thereby improves the digestive system of chick.
The invention provides a kind of feed for raising chick immunocompetence, it comprises: feed vector, Choline Chloride, FE-5, phenylalanine hydrochloride, pantothenic acid, clostridium butyricum, Lactobacillus plantarum, sodium butyrate, stone flour, folic acid, riboflavin, vitamin E, vitamin K, glucolase, amylase, sodium selenate, magnesium sulfate and above-mentioned herbal composite additive.
With respect to the feed vector of 100 weight portions, other each components contents are Choline Chloride 0.3 ~ 0.7 weight portion in the described feed, FE-5 0.7 ~ 1.3 weight portion, phenylalanine hydrochloride 0.5 ~ 1.0 weight portion, pantothenic acid 0.5 ~ 1.5 weight portion, clostridium butyricum 0.4 ~ 0.8 weight portion, Lactobacillus plantarum 0.6 ~ 1.0 weight portion, sodium butyrate 0.6 ~ 1.2 weight portion, stone flour 2 ~ 4 weight portions, folic acid 0.9 ~ 1.7 weight portion, riboflavin 0.6 ~ 1.2 weight portion, vitamin E 0.9 ~ 1.8 weight portion, vitamin K 0.5 ~ 1.5 weight portion, glucolase 0.4 ~ 0.8 weight portion, amylase 0.6 ~ 1.2 weight portion, sodium selenate 0.2 ~ 0.5 weight portion, magnesium sulfate 0.2 ~ 0.5 weight portion, the Chinese medicine composition content of additive is 8 ~ 10 weight portions.
With respect to the feed vector of 100 weight portions, other each components contents Choline Chloride 0.5 weight portion more preferably in the described feed, FE-5 1.1 weight portions, phenylalanine hydrochloride 0.8 weight portion, pantothenic acid 1.1 weight portions, clostridium butyricum 0.6 weight portion, Lactobacillus plantarum 0.8 weight portion, sodium butyrate 1.0 weight portions, stone flour 3 weight portions, folic acid 1.3 weight portions, riboflavin 0.9 weight portion, vitamin e1 .4 weight portion, vitamin K1 .0 weight portion, glucolase 0.6 weight portion, amylase 0.9 weight portion, sodium selenate 0.4 weight portion, magnesium sulfate 0.3 weight portion, the Chinese medicine composition content of additive is 9 weight portions.
Described basal feed composition can be one or more mixing in wheat, corn, barley, dregs of beans, peanut meal and the Chinese sorghum, the more preferably mixing of wheat, corn and peanut meal.
Clostridium butyricum can replenish the normal microorganism species in the enteron aisle; adjust or keep microecological balance in the enteron aisle; on chick intestines wall, grow surely; form the biological protection barrier, and produce organic acid, reduce enteron aisle pH value; suppress the harmful microbe breeding; improve immunoglobulin (Ig) and macrophage activity in the chick body, thereby strengthen the body's immunity of chick, strengthen resistance against diseases.
Described herbal composite additive comprises wilsonii, climbing groundsel, gynostemma pentaphylla, giant knotweed, pollen pini, barrenwort, the seed of feather cockscomb, Fructus Hordei Germinatus, betel nut, dried orange peel, Divine Comedy, asafoetide, the Radix Astragali, the bighead atractylodes rhizome, the fruit of glossy privet, bush, Herba Lycopi, the root of herbaceous peony, reticulate millettia and saline cistanche.
In the described herbal composite additive, the weight fraction of each component is than being wilsonii 30 ~ 40 weight portions, climbing groundsel 14 ~ 24 weight portions, gynostemma pentaphylla 16 ~ 26 weight portions, giant knotweed 15 ~ 25 weight portions, pollen pini 24 ~ 34 weight portions, barrenwort 27 ~ 37 weight portions, the seed of feather cockscomb 8 ~ 18 weight portions, Fructus Hordei Germinatus 37 ~ 47 weight portions, betel nut 18 ~ 28 weight portions, dried orange peel 13 ~ 23 weight portions, Divine Comedy 23 ~ 33 weight portions, asafoetide 25 ~ 35 weight portions, the Radix Astragali 67 ~ 77 weight portions, the bighead atractylodes rhizome 49 ~ 59 weight portions, the fruit of glossy privet 43 ~ 53 weight portions, bush 23 ~ 33 weight portions, Herba Lycopi's 18 ~ 28 weight portions, the root of herbaceous peony 25 ~ 35 weight portions, reticulate millettia 26 ~ 36 weight portions and saline cistanche 16 ~ 26 weight portions.
In the described herbal composite additive, the weight fraction of each component is than also can be wilsonii 35 ~ 40 weight portions, climbing groundsel 19 ~ 24 weight portions, gynostemma pentaphylla 21 ~ 26 weight portions, giant knotweed 20 ~ 25 weight portions, pollen pini 29 ~ 34 weight portions, barrenwort 32 ~ 37 weight portions, the seed of feather cockscomb 13 ~ 18 weight portions, Fructus Hordei Germinatus 42 ~ 47 weight portions, betel nut 23 ~ 28 weight portions, dried orange peel 18 ~ 23 weight portions, Divine Comedy 28 ~ 33 weight portions, asafoetide 30 ~ 35 weight portions, the Radix Astragali 72 ~ 77 weight portions, the bighead atractylodes rhizome 54 ~ 59 weight portions, the fruit of glossy privet 48 ~ 53 weight portions, bush 28 ~ 33 weight portions, Herba Lycopi's 23 ~ 28 weight portions, the root of herbaceous peony 30 ~ 35 weight portions, reticulate millettia 31 ~ 36 weight portions and saline cistanche 21 ~ 26 weight portions.
Each component pharmacology is as follows:
Wilsonii: flavor is hot, bitter, little sweet, warm in nature, go into spleen, kidney, the heart channel of Hang-Shaoyin, have and replenish qi to invigorate the spleen, tonify the kidney to relieve mental strain, the effect of dispelling rheumatism, be used for wind-cold-dampness arthralgia, lumbocrural pain, muscles and bones impotence soft, be slow in action, card such as body void is thin and weak, traumatic injury, fracture, oedema, beriberi, uncontrolled urination are itched, wilsonii helps the vigor of T cell and B cell and the performance of immunoregulatory activity, improves monocyte function, produce cell factor, effectively avoid the generation of chick LADA and anaphylactia.
Climbing groundsel: cold in nature, bitter is returned lung, Liver Channel, has clearing heat and detoxicating, as to make eye bright dampness removing effect, have cards such as carbuncle sore tumefacting virus, cold, fever, red eye, swell pain, dysentery, skin eczema, climbing groundsel has antibacterial activity to staphylococcus aureus, ETEC, shigella dysenteriae.
Gynostemma pentaphylla: cold in nature, flavor is sweet, returns lung, spleen, kidney channel, useful gas is calmed the nerves, and hypotensive effect is used for deficiency of vital energy and physically weak, and weak breath is weak; Vexed insomnia; High blood pressure, Light-headedness; Virus hepatitis; Tumor in digestive tract; The polysaccharide that chronic bronchitis, gynostemma pentaphylla are rich in can improve serum hemolysin content, and humoral immunity is had facilitation, and total saponin(e that gynostemma pentaphylla is rich in can promote lymphocyte transformation, improves the activity of DNA polysaccharide, promotes the synthetic of lymphocyte DNA.
Giant knotweed: mildly bitter flavor, cold nature is returned liver, courage, lung channel, has clearing heat and detoxicating, normalizing gallbladder to cure jaundice, expelling wind and removing dampness, the stasis of blood analgesic therapy of loosing, relieving cough and reducing sputum effect, be used for joint pain, jaundice with damp-heat pathogen is through closing wei lump in the abdomen, coughing with a lot of sputum, scald, injury from falling down, cards such as carbuncle sore tumefacting virus, giant knotweed can promote the immune organ of chick, as the raising of indexes such as thymus gland, spleen and the bursa of farbricius, improve protein metabolism, reduce blood lipid level and cholesterol levels.
Pollen pini: it is sweet, warm in nature to distinguish the flavor of, and returns liver, the spleen channel, has the effect of astringing to arrest bleeding, eliminating dampness and astringing sores, is used for traumatism and bleeding, eczema, impetigo, card such as skin erosion, pus are dripping.
Barrenwort: flavor is hot, sweet, warm in nature, goes into liver, kidney channel, has kidney-replenishing, strengthening the bones and muscles, and the wet effect of dispeling the wind is used for impotence due to deficiency of the kidney, seminal emission premature ejaculation, soft, the cold extremities with aversion to cold of waist knee impotence; Cards such as numbness and ache of cold dampness or spasm of limbs numbness, barrenwort is traditional tonifying kidney and strengthening yang Chinese medicine, is rich in flavone compound, has gonadotropic Effect, directly suppresses the bone absorption and promotes bone to form, and makes organism metabolism be in bone and forms the positive balance state that absorbs greater than bone.
The seed of feather cockscomb: bitter, cold nature is returned Liver Channel, has clearing liver-fire, and the effect of removing nebula cures mainly the hot hot eyes of liver, the living screen film of order, blurring of vision, cards such as hepatopyretic vertigo.
Fructus Hordei Germinatus: it is sweet to distinguish the flavor of, and property is flat, returns spleen, stomach warp, have promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite moves back the effect of newborn dissipate-swelling, cure mainly dyspepsia and do not disappear, abdominal distention and diarrhea rushes down, n and V, poor appetite, milk smoulders, cards such as swollen breasts, contain digestive ferment and B family vitamin in the Fructus Hordei Germinatus, hydrochloric acid in gastric juice and pepsic secretion are had facilitation, itself has aromatic odor Fructus Hordei Germinatus, can improve palatability, induce chick to search for food, promote digesting and assimilating of chick.
Betel nut: bitter, suffering, warm in nature, return stomach, large intestine channel, have desinsection, it is long-pending to disappear, promoting the circulation of qi, Li Shui, the effect of preventing malaria cures mainly abdominal pain due to enterositosis, the stagnant dysentery of rushing down, tenesmus, the oedema beriberi, cards such as malaria, betel nut can promote stomach motion, the secretion that improves motilin and vasoactive intestinal peptide.
Dried orange peel: warm in nature, flavor is hot, bitter; Return spleen, lung channel, be used for diseases such as fullness and oppression of chest and abdomen.The hot logical temperature of loosing of orange peel, fragrant odour is longer than and is regulated the flow of vital energy, and can go into the spleen lung, so can go diffusing sluggishness of lung-QI, again can promoting the circulation of qi wide in, be used for lung qi and gather around stagnant, chest diaphragm ruffian and completely reach cards such as the taste stagnation of the circulation of vital energy, abdominal fullness and distention.
Divine Comedy: Gan Xin, temperature; Go into spleen, stomach warp.Have strengthening the spleen and stomach, effect in the accent that helps digestion cures mainly retention of food and drink, feeling of stuffiness in chest abdominal distension, cards such as vomiting dysentery, Divine Comedy contain amounts of protein, fat, vitamin and necessary amino acid, mineral matter and volatile oil material, strengthening the spleen and stomach, short digestion increases metabolism, stimulate circulation, itself has aromatic odor Divine Comedy, can improve palatability, induces chick to search for food, strengthen the secretion of gastric juice and intestinal juice, promote digesting and assimilating of chick.
Asafoetide: bitter, suffering, warm in nature, return kidney, stomach warp, have disappear long-pending, diffusing ruffian, the effect of desinsection is used for carnivorous stagnant, the hemostasis abdominal mass, mass in abdomen, cards such as abdominal pain due to enterositosis, asafoetide can suppress oxidant and cellular oxidation be modified the cellular damage that causes, can suppress the cell nitric oxide release that oxidation is induced, promote cell proliferation.
The Radix Astragali: bitter, cold in nature, the thoughts of returning home, lung, stomach, courage, large intestine channel have heat-clearing and damp-drying drug, and purging intense heat and detonicating is antiabortive, the effect of hemostasis, the diarrhoea, dysentery, jaundice, the heat that cure mainly due to damp and hot are drenched; The cough with lung heat, thirsty pharyngalgia, also can be used for fetal movement with fever, the malicious fire-evil of heat is invaded the swollen card of sore carbuncle poison of excessive skin, the Radix Astragali comprises polysaccharide, monose, several amino acids and trace element, and wherein, amino acid and trace element can promote body protein metabolism and metabolic function significantly, promote growing of chick, improve the immunoregulation effect of chick.
The bighead atractylodes rhizome: it is sweet, bitter, warm in nature to distinguish the flavor of, and goes into spleen, stomach warp, and the sharp gas of tonifying spleen is arranged, eliminating dampness Li Shui, and strengthening exterior and reducing sweat, the effect that the fortune spleen is moisturized cures mainly ruffian due to the dysfunction of the spleen in transport, the QI failing to transform into body fluid and has one's mind filled with and rush down the phlegm and retained fluid oedema; The vexed lazy speech of the deficiency of qi in middle-jiao, metrorrhagia and metrostaxis, proctoptosis with chronic dysentery; Cards such as solid in the playing of deficiency of the spleen causing weakness of QI, abnormal sweating spontaneous perspiration, the bighead atractylodes rhizome can promote gastric secretion, strengthens the absorption of small intestine, and gastrointestinal function is had regulating action.
The fruit of glossy privet: it is sweet, bitter to distinguish the flavor of, and is slightly cold, and goes into liver, kidney channel, and strong liver kidney-nourishing is arranged, and the effect of removing heat to brighten vision is mainly used in treating liver-kidney Yin deficiency, and the head loses foster dizzy tinnitus, symptoms such as yin asthenia generating intrinsic heat.The fruit of glossy privet can promote leucocyte, strengthens the effect of immunologic function.
Bush: it is sweet, salty to distinguish the flavor of, and property is flat, and the thoughts of returning home, liver, the spleen channel have promoting blood circulation, and the effect of swelling and pain relieving cures mainly traumatic injury, the fracture injury of the tissues, and stasis swells and ache, and through closing dysmenorrhoea, postpartum, the stasis of blood hindered, and the chest ventral spine waits card bitterly.
The Herba Lycopi: bitter, suffering, slightly warm in nature, return liver, the spleen channel, effect: promoting blood circulation and removing blood stasis, line water detumescence is used for all cards of women's multiparity hemostasis, as through closing, dysmenorrhoea, postpartum blood stasis stomachache also is used for oedema, ascites, traumatic injury, cards such as the swollen sore of carbuncle.
The root of herbaceous peony: bitter, acid, cold nature is returned liver, the spleen channel, has nourishing blood for regulating menstruation, astringing YIN to stop sweating, easing the affected liver to relieve pain, the effect of suppressing liver-YANG, it is sallow to cure mainly the deficiency of blood, irregular menstruation, spontaneous perspiration, night sweat, hypochondriac pain, stomachache, four limbs contraction pain, the dizzy dizzy card that waits.
Reticulate millettia: bitter, sweet, warm in nature, return liver, kidney channel, hemangiectasis is arranged, enrich blood and invigorate blood circulation, menstruation regulating, the effect of stimulating the circulation of the blood and cause the muscles and joints to relax has the obvious suppression effect to platelet aggregation, promote animal kidney and the total phosphorus metabolism in uterus, curing mainly the treatment deficiency of blood has the irregular menstruation of silt, and limbs pain is meciless, cards such as soreness and weakness of waist and knees, pain.
Saline cistanche: it is sweet, salty, warm in nature to distinguish the flavor of, and goes into kidney, and large intestine channel has kidney-replenishing, benefiting essence-blood, the effect that relaxes bowel is used for decline of kidney-YANG, and the impotence and premature ejaculation of asthenia of essence and blood is infertile, soreness of waist and knee joint, Hiccough and deaf, frequent micturition urine number, the intestines of the suffering from a deficiency of the kidney deficiency of blood in dry and postpartum, the cards such as constipation that body fluid deficiency after being ill.
The present invention also provides the preparation method of above-mentioned feed, and it comprises:
The first step is ground into 30 orders ~ 50 purpose powder with each component in the feed vector, adds clostridium butyricum and Lactobacillus plantarum subsequently and mixes stirring, and ferment at constant temperature is 15 ~ 20 days under 25 ~ 30 ℃ temperature, obtains the fermented feed carrier;
Second step, each component in the described herbal composite additive is mixed in proportion, add the water with respect to 3 ~ 5 times of mixture qualities subsequently, decocted 2 ~ 4 hours, and filtered, obtain first extract, filter residue adds the water with respect to 1 ~ 3 times of its quality again, decocts 1 ~ 2 hour, filters, obtain second extract, extract is merged, decompression concentrates except anhydrating, obtain dried lotion, adopt the ultra micro flour mill to pulverize, grinding particle size 200 orders ~ 300 orders obtain Powdered Chinese herb feed additive;
In the 3rd step, fermented feed carrier, the Chinese herb feed additive of second step acquisition and other compositions in the described feed that the first step is obtained mix, and obtain mixture, add the water with respect to 3～5 times of mixture qualities, continue to stir 30 minutes ~ 1 hour;
The 4th step, the material that obtains in the 3rd step to be put into the steam modulator under 65 ℃～70 ℃ condition, carry out pre-gelatinization, the gelatinization degree of the feed that obtains is 45～55%;
The 5th step, the material of the 4th pre-gelatinization of step to be carried out steam and boils and push in twin (double) screw extruder, the temperature in the extruder is preferably 100～115 ℃, and pressure is adjusted to 0.5MPa～1.5MPa, is 95～98% until the gelatinization degree of feed;
The 6th step is with the described fodder compound of the dry acquisition of the material that obtains in the 5th step.
The present invention also provides above-mentioned Chinese medicine composition additive for the preparation of improving chick digestive system and immune Application in Food.
Below adopt embodiment to describe embodiments of the present invention in detail, how the application technology means solve technical problem to the present invention whereby, and the implementation procedure of reaching technique effect can fully understand and implements according to this.
Embodiment 1 feed 1
With the 3kg wheat, 6kg corn and 1kg peanut meal are ground into 50 purpose powder, add 60g clostridium butyricum and 80g Lactobacillus plantarum subsequently and mix stirring, ferment at constant temperature is 20 days under 30 ℃ temperature, obtain the fermented feed carrier, with wilsonii 70g, climbing groundsel 38g, gynostemma pentaphylla 42g, giant knotweed 40g, pollen pini 58g, barrenwort 64g, seed of feather cockscomb 26g, Fructus Hordei Germinatus 84g, betel nut 46g, dried orange peel 36g, Divine Comedy 56g, asafoetide 60g, Radix Astragali 144g, bighead atractylodes rhizome 108g, fruit of glossy privet 96g, bush 56g, Herba Lycopi 46g, root of herbaceous peony 60g, reticulate millettia 62g and saline cistanche 42g mix, the water that adds 5kg subsequently, decocted 3 hours, filter, obtain first extract, filter residue adds the water of 500g again, decocted 2 hours, filter, obtain second extract, extract is merged, decompression concentrates except anhydrating, obtain dried lotion, adopt the ultra micro flour mill to pulverize, grinding particle size 300 orders, obtain Powdered Chinese herb feed additive, with the fermented feed carrier 5kg that obtains previously, the 450g Chinese herb feed additive and the Choline Chloride 25g that obtain, FE-5 50g, phenylalanine hydrochloride 40g, pantothenic acid 50g, sodium butyrate 40g, stone flour 150g, folic acid 60g, riboflavin 50g, the 60g vitamin E, the 50g vitamin K, glucolase 30g, amylase 50g, sodium selenate 20g, magnesium sulfate 15g mixes, obtain mixture, the water that adds 20kg, continue to stir 1 hour, the material that obtains is put into the steam modulator under 70 ℃ condition, carry out pre-gelatinization, the gelatinization degree of the feed that obtains is 55%, the material of pre-gelatinization is carried out steam in twin (double) screw extruder boil and push, temperature in the extruder is preferably 100 ℃, pressure is adjusted to 1MPa, gelatinization degree until feed is 98%, the described feed 1 of dry acquisition.
Embodiment 2 feeds 2
With the 3kg wheat, 6kg corn and 1kg peanut meal are ground into 50 purpose powder, add 60g clostridium butyricum and 80g Lactobacillus plantarum subsequently and mix stirring, ferment at constant temperature is 20 days under 30 ℃ temperature, obtain the fermented feed carrier, with wilsonii 67g, climbing groundsel 41g, gynostemma pentaphylla 45g, giant knotweed 42g, pollen pini 62g, barrenwort 68g, seed of feather cockscomb 30g, Fructus Hordei Germinatus 88g, betel nut 50g, dried orange peel 42g, Divine Comedy 60g, asafoetide 35g, Radix Astragali 150g, bighead atractylodes rhizome 112g, fruit of glossy privet 98g, bush 60g, Herba Lycopi 52g, root of herbaceous peony 64g, reticulate millettia 66g and saline cistanche 47g mix, the water that adds 5kg subsequently, decocted 3 hours, filter, obtain first extract, filter residue adds the water of 500g again, decocted 2 hours, filter, obtain second extract, extract is merged, decompression concentrates except anhydrating, obtain dried lotion, adopt the ultra micro flour mill to pulverize, grinding particle size 300 orders, obtain Powdered Chinese herb feed additive, with the fermented feed carrier 5kg that obtains previously, the 450g Chinese herb feed additive and the Choline Chloride 25g that obtain, FE-5 50g, phenylalanine hydrochloride 40g, pantothenic acid 50g, sodium butyrate 40g, stone flour 150g, folic acid 60g, riboflavin 50g, the 60g vitamin E, the 50g vitamin K, glucolase 30g, amylase 50g, sodium selenate 20g, magnesium sulfate 15g mixes, obtain mixture, the water that adds 20kg, continue to stir 1 hour, the material that obtains is put into the steam modulator under 70 ℃ condition, carry out pre-gelatinization, the gelatinization degree of the feed that obtains is 55%, the material of pre-gelatinization is carried out steam in twin (double) screw extruder boil and push, temperature in the extruder is preferably 100 ℃, pressure is adjusted to 1MPa, gelatinization degree until feed is 98%, the described feed 2 of dry acquisition.
Clinical trial
1. animal used as test
300 SPF chick are purchased in academy of agricultural sciences, Shandong Province poultry institute, choose 60 and carry out toxicity test, remainingly are divided into three groups, every group each 80, are respectively first experimental group, second experimental group and control group.
2. experiment material
Control group is from the feed of the method preparation of 1 age in days feeding such as embodiment 1, institute's difference is not add Chinese herb feed additive, first experimental group is from the feed 1 of 1 age in days feeding embodiment, 1 preparation, second experimental group is from the feed 2 of 1 age in days feeding embodiment, 2 preparations, respectively when 5,10,15,20 ages in days every group cut open and kill 20, weigh, take a blood sample before cuing open extremely, separation of serum, get thymus gland, spleen, bursa of farbricius immune organ and weigh, and it is fixing to put into 2.5% neutral formalin fixer together with liver, duodenum, jejunum, ileum, cecal tonsil.
3. toxicity test
60 chick are divided into 2 groups, 30 every group, take the feed 1 of embodiment 1 preparation and the feed 2 of embodiment 2 preparations respectively, continuous 120 days, 24 hours each groups were lived and are killed 1/2 animal (male and female half and half) after the last administration, all the other 1/2 animals continue to observe 2 week the back live and kill.Duration of test is observed outward appearance, general behavior, food ration, the changes of weight of animal, takes feed 120 days and cuts out index inspections such as carrying out hematology (RBC, HB, granulophilocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, Histopathology in 2 weeks of feed.Result of the test shows: the animal general state of taking feed 1 is good, and outward appearance sign, behavioral activity, food-intake and body weight gain be no abnormal variation all; Hematological examination, blood biochemical, urine biochemical analysis are all in normal range (NR); The main organs histopathological examination shows no obvious abnormalities.These parameters cuts out feed and does not also see change after 2 weeks.This test did not have obvious influence to rat in continuous 120 days with feed 1 and feed 2, no clear and definite toxicity target organ and sensitive indicator, and convalescence observes and does not also see the retardance toxic reaction, and the security of prompting feed 1 and feed 2 clinical practices is higher.
4. the mensuration of immune organ index
After the weighing for the last time of feeding experiment, whenever repeat to select 1 chick near average weight and slaughter, win spleen and the bursa of farbricius respectively and claim fresh weight.
Thymus index (g/kg)=thymus gland fresh weight/live body is heavy
Index and spleen index (g/kg)=spleen fresh weight/live body is heavy
Bursa of farbricius index (g/kg)=bursa of farbricius fresh weight/live body is heavy.
5. digestion experiment
5 days testing periods, fresh excreta is collected on 15 ~ 20 age in days every hurdles every day, adds watery hydrochloric acid fixed nitrogen.Finish the back and mix 70 ℃ of oven dry.Preserve the feed sample simultaneously.National Standard Method is measured dry, crude protein, crude fat, calcium, phosphorus, the acid-insoluble ash equal size in feed, the chicken manure, is the agent of endogenous index with the acid-insoluble ash, calculates the apparent digestibility of feed nutrient.
6. data are handled
Use SAS/PC(6.0) software, carry out statistical analysis by the one-way analysis of variance method to the test data of every index.As significant difference, carry out multiple ratio with the q method of inspection.
7. result and analysis
7.1 feed is to the influence of chick daily ingestion amount
Table 1 feed is to the influence of chick daily ingestion amount
As can be seen from Table 1, compare with control group, the significant raising that the feed of employing Chinese herb feed additive of the present invention obtains aspect the daily ingestion amount of chick, thus proof has been improved the digestive system of chick.
7.2 feed is to the influence of chick thymus index
Table 2 feed is to the influence of chick thymus index
As can be seen from Table 2, experimental group thymus index mean value all is higher than control group at variant age in days section, thereby proves that it can improve the immunologic function of chick.
7.3 feed is to the influence of chick index and spleen index
Table 3 feed is to the influence of chick index and spleen index
As can be seen from Table 3, experimental group index and spleen index mean value all is higher than control group at variant age in days section, thereby proves that it can improve the immunologic function of chick.
7.4 feed is to the influence of chick bursa of farbricius index
Table 4 feed is to the influence of chick bursa of farbricius index
7.5 the apparent digestibility of nutritional labeling in the feed
The apparent digestibility of nutritional labeling in table 5 feed
As can be seen from Table 5, adopt the digestibility of feed crude fat of the present invention, crude protein, calcium and total phosphorus to significantly improve than control group.
This intellectual property of primary enforcement that all are above-mentioned is not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above only is preferred embodiment of the present invention, is not to be the restriction of the present invention being made other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not break away to any simple modification, equivalent variations and remodeling that above embodiment does, still belongs to the protection domain of technical solution of the present invention according to technical spirit of the present invention.
Claims (5)
1. feed that be used for to improve the chick immunocompetence, it is characterized in that, comprising: feed vector, Choline Chloride, FE-5, phenylalanine hydrochloride, pantothenic acid, clostridium butyricum, Lactobacillus plantarum, sodium butyrate, stone flour, folic acid, riboflavin, vitamin E, vitamin K, glucolase, amylase, sodium selenate, magnesium sulfate and herbal composite additive;
With respect to the feed vector of 100 weight portions, other each components contents are Choline Chloride 0.3 ~ 0.7 weight portion in the described feed, FE-5 0.7 ~ 1.3 weight portion, phenylalanine hydrochloride 0.5 ~ 1.0 weight portion, pantothenic acid 0.5 ~ 1.5 weight portion, clostridium butyricum 0.4 ~ 0.8 weight portion, Lactobacillus plantarum 0.6 ~ 1.0 weight portion, sodium butyrate 0.6 ~ 1.2 weight portion, stone flour 2 ~ 4 weight portions, folic acid 0.9 ~ 1.7 weight portion, riboflavin 0.6 ~ 1.2 weight portion, vitamin E 0.9 ~ 1.8 weight portion, vitamin K 0.5 ~ 1.5 weight portion, glucolase 0.4 ~ 0.8 weight portion, amylase 0.6 ~ 1.2 weight portion, sodium selenate 0.2 ~ 0.5 weight portion, magnesium sulfate 0.2 ~ 0.5 weight portion, the herbal composite content of additive is 8 ~ 10 weight portions;
Described feed vector is one or more mixing in wheat, corn, barley, dregs of beans, peanut meal and the Chinese sorghum;
Described herbal composite additive comprises wilsonii, climbing groundsel, gynostemma pentaphylla, giant knotweed, pollen pini, barrenwort, the seed of feather cockscomb, Fructus Hordei Germinatus, betel nut, dried orange peel, Divine Comedy, asafoetide, the Radix Astragali, the bighead atractylodes rhizome, the fruit of glossy privet, bush, Herba Lycopi, the root of herbaceous peony, reticulate millettia and saline cistanche;
In the described herbal composite additive, the parts by weight of each component are wilsonii 30 ~ 40 weight portions, climbing groundsel 14 ~ 24 weight portions, gynostemma pentaphylla 16 ~ 26 weight portions, giant knotweed 15 ~ 25 weight portions, pollen pini 24 ~ 34 weight portions, barrenwort 27 ~ 37 weight portions, the seed of feather cockscomb 8 ~ 18 weight portions, Fructus Hordei Germinatus 37 ~ 47 weight portions, betel nut 18 ~ 28 weight portions, dried orange peel 13 ~ 23 weight portions, Divine Comedy 23 ~ 33 weight portions, asafoetide 25 ~ 35 weight portions, the Radix Astragali 67 ~ 77 weight portions, the bighead atractylodes rhizome 49 ~ 59 weight portions, the fruit of glossy privet 43 ~ 53 weight portions, bush 23 ~ 33 weight portions, Herba Lycopi's 18 ~ 28 weight portions, the root of herbaceous peony 25 ~ 35 weight portions, reticulate millettia 26 ~ 36 weight portions and saline cistanche 16 ~ 26 weight portions.
2. feed as claimed in claim 1, it is characterized in that: with respect to the feed vector of 100 weight portions, other each components contents are Choline Chloride 0.5 weight portion in the described feed, FE-5 1.1 weight portions, phenylalanine hydrochloride 0.8 weight portion, pantothenic acid 1.1 weight portions, clostridium butyricum 0.6 weight portion, Lactobacillus plantarum 0.8 weight portion, sodium butyrate 1.0 weight portions, stone flour 3 weight portions, folic acid 1.3 weight portions, riboflavin 0.9 weight portion, vitamin e1 .4 weight portion, vitamin K1 .0 weight portion, glucolase 0.6 weight portion, amylase 0.9 weight portion, sodium selenate 0.4 weight portion, magnesium sulfate 0.3 weight portion, the herbal composite content of additive is 9 weight portions.
3. feed as claimed in claim 1, it is characterized in that: in the described herbal composite additive, the parts by weight of each component are wilsonii 35 ~ 40 weight portions, climbing groundsel 19 ~ 24 weight portions, gynostemma pentaphylla 21 ~ 26 weight portions, giant knotweed 20 ~ 25 weight portions, pollen pini 29 ~ 34 weight portions, barrenwort 32 ~ 37 weight portions, the seed of feather cockscomb 13 ~ 18 weight portions, Fructus Hordei Germinatus 42 ~ 47 weight portions, betel nut 23 ~ 28 weight portions, dried orange peel 18 ~ 23 weight portions, Divine Comedy 28 ~ 33 weight portions, asafoetide 30 ~ 35 weight portions, the Radix Astragali 72 ~ 77 weight portions, the bighead atractylodes rhizome 54 ~ 59 weight portions, the fruit of glossy privet 48 ~ 53 weight portions, bush 28 ~ 33 weight portions, Herba Lycopi's 23 ~ 28 weight portions, the root of herbaceous peony 30 ~ 35 weight portions, reticulate millettia 31 ~ 36 weight portions and saline cistanche 21 ~ 26 weight portions.
4. the preparation method of each described feed of claim 1 to 3 is characterized in that, comprising:
The first step is ground into 30 orders ~ 50 purpose powder with each component in the feed vector, adds clostridium butyricum and Lactobacillus plantarum subsequently and mixes stirring, and ferment at constant temperature is 15 ~ 20 days under 25 ~ 30 ℃ temperature, obtains the fermented feed carrier;
Second step, each component in the described herbal composite additive is mixed in proportion, add the water with respect to 3 ~ 5 times of mixture qualities subsequently, decocted 2 ~ 4 hours, and filtered, obtain first extract, filter residue adds the water with respect to 1 ~ 3 times of its quality again, decocts 1 ~ 2 hour, filters, obtain second extract, extract is merged, decompression concentrates except anhydrating, obtain dried lotion, adopt the ultra micro flour mill to pulverize, grinding particle size 200 orders ~ 300 orders obtain Powdered Chinese herb feed additive;
In the 3rd step, fermented feed carrier, the Chinese herb feed additive of second step acquisition and other compositions in the described feed that the first step is obtained mix, and obtain mixture, add the water with respect to 3～5 times of mixture qualities, continue to stir 30 minutes ~ 1 hour;
The 4th step, the material that obtains in the 3rd step to be put into the steam modulator under 65 ℃～70 ℃ condition, carry out pre-gelatinization, the gelatinization degree of the feed that obtains is 45～55%;
The 5th step, the material of the 4th pre-gelatinization of step to be carried out steam and boils and push in twin (double) screw extruder, the temperature in the extruder is 100～115 ℃, pressure is adjusted to 0.5MPa～1.5MPa, is 95～98% until the gelatinization degree of feed;
The 6th step is with the described feed of the dry acquisition of the material that obtains in the 5th step.
5. the herbal composite additive in the described feed of one of claim 1 to 3 is for the preparation of improving chick digestive system and immune Application in Food.
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Effective date of registration: 20170719 Address after: 261100 Shandong city of Weifang province Hanting Zhu District Subdistrict Office Community Beach (East intersection ring and Fu Ting Street East 800 meters) Patentee after: Weifang new hope six and feed Technology Co., Ltd. Address before: Laoshan District of Shandong city of Qingdao province Hongkong 266061 Road No. 362 Nonghaiyuan business building 3 floor Patentee before: Shandong New Hope Liuhe Group Co., Ltd. |