CN102772396A - Cooperatively used combination type preparation for cleaning and sterilizing skin after being bitten or scratched by animals - Google Patents
Cooperatively used combination type preparation for cleaning and sterilizing skin after being bitten or scratched by animals Download PDFInfo
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- CN102772396A CN102772396A CN201210259183XA CN201210259183A CN102772396A CN 102772396 A CN102772396 A CN 102772396A CN 201210259183X A CN201210259183X A CN 201210259183XA CN 201210259183 A CN201210259183 A CN 201210259183A CN 102772396 A CN102772396 A CN 102772396A
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Abstract
The invention relates to a cooperatively used combination type preparation for cleaning and sterilizing skin after being bitten or scratched by animals. The purpose of the invention is to provide a cooperatively used combination type preparation for cleaning and sterilizing skin after being bitten or scratched by animals with the characteristics of simple preparation, good stability, ease use and good use effect. The technical solution provided by the invention is as follows: the cooperatively used combination type preparation for cleaning and sterilizing skin after being bitten or scratched by animals is characterized in that the combination type preparation comprises a weakly alkaline cleaner and a skin antibacterial spray; the raw materials of the weakly alkaline cleaner include benzalkonium chloride or benzalkonium bromide, 30% dodecyl dimethyl amine oxide solution and polysorbate 20; the raw materials of the skin antibacterial spray include benzalkonium bromide, or benzalkonium chloride, or chlorhexidine, or chlorhexidine acetate, or chlorhexidine hydrochloride, or chlorhexidine citrate, or 20% chlorhexidine gluconate solution and polysorbate 20. The preparation provided by the invention is applied to the treatments of cleaning and sterilizing the skin wounds after being bitten or scratched by dogs, cats and other animals.
Description
Technical field
The present invention relates to the antimicrobial preparation of a kind of cleaning, especially a kind ofly be used for animal and grab the antibiotic and combined preparation that is used of back skin clean that bites.Be applicable to animal bites such as dog, cat, the cleaning of the skin wound after scratching is cleaned, disinfecting, antimicrobial is handled.
Background technology
As perhaps be not sure of healthy rabies host animal (like mammals such as Canis familiaris L., cat, bat bats) by mad dog, doubtful mad dog accidentally and bite, scratch, lick and lick mucosa or damaged skin place; Have very big causing a disease or even fatal danger; Must not be careless, must handle rapidly.So all to be not sure of the animal of hurting sb.'s feelings be healthy animal, should carry out wound clean and use disinfecting, antimicrobial liquid to handle according to World Health Organization's guideline, will go to institute of professional medical mechanism to send for a doctor to handle then as soon as possible at once.
By Ministry of Public Health prevention and control of diseases office " flow chart is disposed in prevention after the rabies exposure " requirement; At present the commercially available prod has two kinds of methods 1. to use suds (or other alkalescence cleaning agent) and mobile clear water (or normal saline) alternately to clean a wound at least 15 minutes to the processing of wound, uses povidone iodine (or iodine tincture, ethanol) sterilization wound then.2. use suds (or other alkalescence cleaning agent) and mobile clear water (or normal saline) alternately to clean a wound at least 15 minutes, then with other disinfecting, antimicrobial agent sterilization wounds.Commercially available disinfecting, antimicrobial agent commonly used is generally cationic surfactants such as hibitane class (hibitane class), strand or double-chain quaternary ammonium salt class.
Yet there is following problem in the above-mentioned processing method: Diazolidinyl Urea mucosa when the iodine tincture in the first method, ethanol are used to have the skin of damaged wound and produce violent pain.Suds commonly used in the second method are anion surfactant; When the cationic surfactant in the disinfecting, antimicrobial agent runs into anion surfactant, can take place to neutralize to send out and answer; So that the curative effect of disinfecting, antimicrobial agent reduces even lost efficacy; Particularly clean thoroughly and have locally when residual when suds, this situation more is prone to take place.
Summary of the invention
The technical problem that the present invention will solve is: to the problem of above-mentioned existence; Provide a kind of and prepare easy, good stability, the easy to use and animal that is used for that result of use is good grabs the combined preparation that the back skin clean is antibiotic and be used that bites; Reduce to skin and mucous membrane irritation the problem of avoiding the zwitterion neutralization to cause the disinfecting, antimicrobial effect to reduce or lost efficacy.
The technical scheme that the present invention adopted is: be used for animal and grab the combined preparation that the back skin clean is antibiotic and be used that bites, it is characterized in that this combined preparation comprises alkalescence cleaning agent and skin antimicrobial spray:
1.1 the alkalescence cleaning agent that is used with the skin antimicrobial spray; Raw material comprises benzalkonium chloride or benzalkonium bromide, 30% dodecayl dimethyl amine oxide solution and polysorbate 20; Be by ratio of weight and the number of copies: 1.5 ~ 2.5 parts of BZK or benzalkonium bromides; 2.5 ~ 3.5 parts of 30% dodecayl dimethyl amine oxide solution, 0.5 ~ 1.5 part of polysorbate 20;
1.2 the preparation technology of said alkalescence cleaning agent is:
Add in 60 ℃ of an amount of purified water 1.2.1 take by weighing benzalkonium chloride or benzalkonium bromide in proportion, fully stirring makes it to dissolve fully, gets solution 1;
1.2.2 60% of the adding full dose purified water adds all the other raw materials of filling a prescription in preparing tank, stirring and dissolving gets solution 2;
1.2.3 solution 1 is added in the preparing tank, add purified water and be settled to full dose, stirring and evenly mixing gets intermediate;
1.2.4 detect character, pH value, the content of intermediate;
1.2.5 filtration, fill;
1.3 the skin antimicrobial spray that is used with the alkalescence cleaning agent; Raw material comprises the chlorhexidine gluconate solution and the polysorbate 20 of benzalkonium bromide or benzalkonium chloride, hibitane or chlorhexidine acetate or chlorhexidine hydrochloride or citric acid hibitane or 20%; Be by ratio of weight and the number of copies: 0.5 ~ 1.5 part of benzalkonium bromide or benzalkonium chloride; 20 ~ 30 parts of 3 ~ 7 parts of hibitane or chlorhexidine acetate or chlorhexidine hydrochloride or citric acid hibitane or 20% chlorhexidine gluconate solution, 1 ~ 3 part of polysorbate 20;
1.4 the preparation technology of said skin antimicrobial spray is:
Add in 60 ℃ of an amount of purified water 1.4.1 take by weighing benzalkonium bromide or benzalkonium chloride, fully stir and make it to dissolve fully by prescription, solution 1;
1.4.2 60% of the adding full dose purified water adds all the other raw materials of filling a prescription in preparing tank, stirring and dissolving gets solution 2;
1.4.3 solution 1 is added in the preparing tank, add purified water and be settled to full dose, stirring and evenly mixing gets intermediate;
1.4.4 detect character, pH value, the content of intermediate;
1.4.5 filtration, fill;
1.5 the alkalescence cleaning agent of fill and skin antimicrobial spray place in the same packing box respectively.
The HCl or the NaOH that also comprise 0.01mol/L in the prescription of step 1.1 and step 1.3 regulate alkalescence cleaning agent pH value to 6.5 ~ 9.0, regulate skin antimicrobial spray pH value to 5.5 ~ 8.5.
The invention has the beneficial effects as follows: alkalescence cleaning agent of the present invention and skin antimicrobial spray prepare easy, good stability, easy to use and animal bites such as dog, cat, scratch etc. are had good disinfecting, antimicrobial effect; To mucocutaneous non-stimulated, can not produce zwitterion neutralization send out should and reduce drug effect.After pH value regulator (HCl of 0.01mol/L or NaOH solution) was regulated, alkalescence cleaning agent and skin antimicrobial spray can store at steady quality in the room temperature storage 24 months for a long time.
The specific embodiment
Embodiment 1:
1. prepare the alkalescence cleaning agent
1, component:
Benzalkonium chloride 2g
30% dodecayl dimethyl amine oxide solution (OB-2) 3.33g
Polysorbate 20 1g
Purified water adds to 1000ml
2, processing step:
(1) benzalkonium chloride of getting in the component adds in 60 ℃ of an amount of purified water, fully stirs to make it to dissolve fully, gets solution 1;
(2) add the purified water of full dose 60% again in the preparing tank, add all the other raw materials in the component, stirring and dissolving, solution 2;
(3) solution 1 is added in the preparing tank, adds purified water and be settled to 1000ml, stirring and evenly mixing gets intermediate;
(4) intermediate detects (detect index: character is colourless or flaxen supernatant liquid, pH value, content), and the HCl or the NaOH solution that add 0.01mol/L are to regulate in pH value to 6.5 ~ 9.0 scopes;
(5) filtration, fill.
2. prepare the skin antimicrobial spray
1, component:
Benzalkonium bromide 1g
Hibitane 5g
Polysorbate 20 2g
Purified water adds to 1000ml
2, processing step:
(1) benzalkonium bromide of getting in the component adds in 60 ℃ of an amount of purified water, fully stirs to make it to dissolve fully, gets solution 1;
(2) purified water of adding full dose 60% in preparing tank adds all the other raw materials in the component, and stirring and dissolving gets solution 2;
(3) solution 1 is added in the preparing tank, adds purified water and be settled to 1000ml, stirring and evenly mixing gets intermediate;
(4) intermediate detects (detect index: character is colourless or flaxen supernatant liquid, pH value, content), and the HCl or the NaOH solution that add 0.01mol/L are to regulate in pH value to 5.5 ~ 8.5 scopes;
(5) filtration, fill.
Also available chlorhexidine acetate of hibitane or chlorhexidine hydrochloride or citric acid hibitane replace in the said components.
The alkalescence cleaning agent of fill and skin antimicrobial spray place in the same packing box respectively at last, warehouse-in.Animal bite such as dog, cat, be used this combined preparation after scratching, in time to wound clean cleaning, disinfecting, antimicrobial is handled.
Embodiment 2:
1. prepare the alkalescence cleaning agent
1, component:
Benzalkonium bromide 1.5g
30% dodecayl dimethyl amine oxide solution (OB-2) 2.5g
Polysorbate 20 0.5g
Purified water adds to 1000ml
2, processing step:
(1) get in 60 ℃ of purified water of benzalkonium bromide adding of recipe quantity, fully stirring makes it to dissolve fully, gets solution 1;
(2) purified water of adding full dose 60% in preparing tank adds all the other raw materials in the component, and stirring and dissolving gets solution 2;
(3) solution 1 is added in the preparing tank, add purified water and be settled to 1000ml, stirring and evenly mixing gets intermediate;
(4) intermediate detects (detect index: character is colourless or flaxen supernatant liquid, pH value, content), and the HCl or the NaOH solution that add 0.01mol/L are to regulate in pH value to 6.5 ~ 9.0 scopes;
(5) filtration, fill.
2. prepare the skin antimicrobial spray
1, component:
Benzalkonium chloride 0.5g
Chlorhexidine acetate 3g
Polysorbate 20 1g
Purified water adds to 1000ml
2, processing step:
(1) benzalkonium chloride of getting in the component adds in 60 ℃ of purified water, fully stirs to make it to dissolve fully, gets solution 1;
(2) purified water of adding full dose 60% in preparing tank adds all the other raw materials in the component, and stirring and dissolving gets solution 2;
(3) solution 1 is added in the preparing tank, add purified water and be settled to 1000ml, stirring and evenly mixing gets intermediate;
(4) intermediate detects (detect index: character is colourless or flaxen supernatant liquid, pH value, content), and the HCl or the NaOH solution that add 0.01mol/L are to regulate in pH value to 5.5 ~ 8.5 scopes;
(5) filtration, fill.
The alkalescence cleaning agent of fill and skin antimicrobial spray place in the same packing box respectively at last, warehouse-in.
Embodiment 3:
1. prepare the alkalescence cleaning agent
1, component:
Benzalkonium chloride 2.5g
30% dodecayl dimethyl amine oxide solution (OB-2) 3.5g
Polysorbate 20 1.5g
Purified water adds to 1000ml
2, processing step:
(1) benzalkonium chloride of getting in the component adds in 60 ℃ of purified water, fully stirs to make it to dissolve fully, gets solution 1;
(2) purified water of adding full dose 60% in preparing tank adds all the other raw materials in the component, and stirring and dissolving gets solution 2;
(3) solution 1 is added in the preparing tank, add purified water and be settled to 1000ml, stirring and evenly mixing gets intermediate;
(4) intermediate detects (detect index: character is colourless or flaxen supernatant liquid, pH value, content), and the HCl or the NaOH solution that add 0.01mol/L are to regulate in pH value to 6.5 ~ 9.0 scopes;
(5) filtration, fill.
2. prepare the skin antimicrobial spray
1, prescription:
Benzalkonium chloride 1.5g
20% chlorhexidine gluconate solution 25g
Polysorbate 20 3g
Purified water adds to 1000ml
2, processing step:
(1) benzalkonium chloride of getting in the component adds in 60 ℃ of purified water, fully stirs to make it to dissolve fully, gets solution 1;
(2) purified water of adding full dose 60% in preparing tank adds all the other raw materials in the component, and stirring and dissolving gets solution 2;
(3) solution 1 is added in the preparing tank, add purified water and be settled to 1000ml, stirring and evenly mixing gets intermediate;
(4) intermediate detects (detect index: character is colourless or flaxen supernatant liquid, pH value, content), and the HCl or the NaOH solution that add 0.01mol/L are to regulate in pH value to 5.5 ~ 8.5 scopes;
(5) filtration, fill.
The alkalescence cleaning agent of fill and skin antimicrobial spray place in the same packing box respectively at last, warehouse-in.
In the foregoing description, the cationic surfactant in the preparation skin antimicrobial spray can also be chlorhexidine hydrochloride or citric acid hibitane.
In the foregoing description, said benzalkonium chloride, benzalkonium bromide, dodecayl dimethyl amine oxide, hibitane or chlorhexidine acetate or chlorhexidine hydrochloride or citric acid hibitane or chlorhexidine gluconate, polysorbate 20 and purified water are the commercially available prod.
Benzalkonium chloride another name benzalkonium chloride, benzalkonium bromide another name benzalkonium bromide; Both are cationic surfactant class wide-spectrum bactericide; Can change antibacterial endochylema membrane permeability, thalline endochylema material is exosmosed, hinder its metabolism and a killing action; Stronger to the gram-positive bacteria effect, be usually used in the treatment of cleaning and sterilizing, wound and the burn infection of skin and mucosa and wound, the sterilization and the preservation of operating theater instruments tool.
Hibitane or chlorhexidine acetate or chlorhexidine gluconate or chlorhexidine hydrochloride or citric acid hibitane; Their corresponding another names are respectively hibitane, chlorhexidine acetate, chlorhexidine gluconate, chlorhexidine hydrochloride, citrate hibitane; Five kinds of hibitane are cationic surfactant; Broad-spectrum sterilization, bacteriostasis are arranged, and antimicrobial spectrum comprises Grain-positive and negative bacterium, fungus and some virus.After it is adsorbed in cell wall, change its surface texture and Osmotic balance, endochylema composition seepage can make endochylema solidify during high concentration, suppressed the reparation of cell wall, and this model of action is difficult for producing drug resistance, is used for hands, skin, mucosa, wound surface and sterilization of instruments.
The water of 18.02 article of purified water H2O hyoscine that to be drinking water make through the way of distillation, ion exchange, hyperfiltration or other suitable methods does not contain any additives.
Dodecayl dimethyl amine oxide, commodity are called OA-12, OB-2; Be a kind of amphoteric surfactant, be colourless transparent liquid, in acid medium, be cationic; In alkaline medium, be nonionic, foam that tool is good and detergency ability also have characteristics such as antibacterial and easily biological-degradable.
Polysorbate 20, the another name polysorbas20 is nonionic surfactant, has emulsifying and hydrotropy effect.
Claims (2)
1. be used for animal and grab the combined preparation that the back skin clean is antibiotic and be used that bites, it is characterized in that this combined preparation comprises alkalescence cleaning agent and skin antimicrobial spray:
1.1 the alkalescence cleaning agent that is used with the skin antimicrobial spray; Raw material comprises benzalkonium chloride or benzalkonium bromide, 30% dodecayl dimethyl amine oxide solution and polysorbate 20; Be by ratio of weight and the number of copies: 1.5 ~ 2.5 parts of BZK or benzalkonium bromides; 2.5 ~ 3.5 parts of 30% dodecayl dimethyl amine oxide solution, 0.5 ~ 1.5 part of polysorbate 20;
1.2 the preparation technology of said alkalescence cleaning agent is:
Add in 60 ℃ of an amount of purified water 1.2.1 take by weighing benzalkonium chloride or benzalkonium bromide in proportion, fully stirring makes it to dissolve fully, gets solution 1;
1.2.2 60% of the adding full dose purified water adds all the other raw materials of filling a prescription in preparing tank, stirring and dissolving gets solution 2;
1.2.3 solution 1 is added in the preparing tank, add purified water and be settled to full dose, stirring and evenly mixing gets intermediate;
1.2.4 detect character, pH value, the content of intermediate;
1.2.5 filtration, fill;
1.3 the skin antimicrobial spray that is used with the alkalescence cleaning agent; Raw material comprises the chlorhexidine gluconate solution and the polysorbate 20 of benzalkonium bromide or benzalkonium chloride, hibitane or chlorhexidine acetate or chlorhexidine hydrochloride or citric acid hibitane or 20%; Be by ratio of weight and the number of copies: 0.5 ~ 1.5 part of benzalkonium bromide or benzalkonium chloride; 20 ~ 30 parts of 3 ~ 7 parts of hibitane or chlorhexidine acetate or chlorhexidine hydrochloride or citric acid hibitane or 20% chlorhexidine gluconate solution, 1 ~ 3 part of polysorbate 20;
1.4 the preparation technology of said skin antimicrobial spray is:
Add in 60 ℃ of an amount of purified water 1.4.1 take by weighing benzalkonium bromide or benzalkonium chloride, fully stir and make it to dissolve fully by prescription, solution 1;
1.4.2 60% of the adding full dose purified water adds all the other raw materials of filling a prescription in preparing tank, stirring and dissolving gets solution 2;
1.4.3 solution 1 is added in the preparing tank, add purified water and be settled to full dose, stirring and evenly mixing gets intermediate;
1.4.4 detect character, pH value, the content of intermediate;
1.4.5 filtration, fill;
1.5 the alkalescence cleaning agent of fill and skin antimicrobial spray place in the same packing box respectively.
2. combined preparation according to claim 1 is characterized in that: also comprise HCl or the NaOH of 0.01mol/L in the prescription of step 1.1 and step 1.3, regulate alkalescence cleaning agent pH value to 6.5 ~ 9.0, regulate skin antimicrobial spray pH value to 5.5 ~ 8.5.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201210259183 CN102772396B (en) | 2012-07-25 | 2012-07-25 | Cooperatively used combination type preparation for cleaning and sterilizing skin after being bitten or scratched by animals |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201210259183 CN102772396B (en) | 2012-07-25 | 2012-07-25 | Cooperatively used combination type preparation for cleaning and sterilizing skin after being bitten or scratched by animals |
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| CN102772396B CN102772396B (en) | 2013-12-18 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104188848A (en) * | 2014-08-06 | 2014-12-10 | 杭州普瑞美克生物科技有限公司 | Cooperatively used combined bag for cleaning and disinfecting skin after dog and animal injuries |
| CN104958283A (en) * | 2015-06-02 | 2015-10-07 | 北京盛大康成医疗技术有限公司 | Alkalescence skin mucosa cleaning and disinfecting composition and preparing method and application thereof |
| US9403702B1 (en) * | 2015-06-13 | 2016-08-02 | A Better Life Worldwide, Llc | Commodity water purifier |
| CN107789209A (en) * | 2017-11-01 | 2018-03-13 | 上海展艺商贸有限公司 | Alkaline electrolyte water antimicrobial fluid and antibacterial wet tissue |
| CN109157646A (en) * | 2018-10-10 | 2019-01-08 | 杭州普瑞美克生物科技有限公司 | The preparation method of the clean negative antimicrobial spray of the stream of people and combined preparation |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1327382A (en) * | 1998-12-23 | 2001-12-19 | 伊迪亚股份公司 | Improved formulation for topical non-invasive application in vivo |
| US20110212035A1 (en) * | 2010-02-26 | 2011-09-01 | Collegium Pharmaceutical, Inc. | Emollient foams for treatment of dermatoses |
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2012
- 2012-07-25 CN CN 201210259183 patent/CN102772396B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1327382A (en) * | 1998-12-23 | 2001-12-19 | 伊迪亚股份公司 | Improved formulation for topical non-invasive application in vivo |
| US20110212035A1 (en) * | 2010-02-26 | 2011-09-01 | Collegium Pharmaceutical, Inc. | Emollient foams for treatment of dermatoses |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104188848A (en) * | 2014-08-06 | 2014-12-10 | 杭州普瑞美克生物科技有限公司 | Cooperatively used combined bag for cleaning and disinfecting skin after dog and animal injuries |
| CN104958283A (en) * | 2015-06-02 | 2015-10-07 | 北京盛大康成医疗技术有限公司 | Alkalescence skin mucosa cleaning and disinfecting composition and preparing method and application thereof |
| US9403702B1 (en) * | 2015-06-13 | 2016-08-02 | A Better Life Worldwide, Llc | Commodity water purifier |
| CN107789209A (en) * | 2017-11-01 | 2018-03-13 | 上海展艺商贸有限公司 | Alkaline electrolyte water antimicrobial fluid and antibacterial wet tissue |
| CN109157646A (en) * | 2018-10-10 | 2019-01-08 | 杭州普瑞美克生物科技有限公司 | The preparation method of the clean negative antimicrobial spray of the stream of people and combined preparation |
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| CN102772396B (en) | 2013-12-18 |
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