CN102703329B - 一株高效转化黄姜中皂苷生产薯蓣皂苷元的菌株及其应用 - Google Patents
一株高效转化黄姜中皂苷生产薯蓣皂苷元的菌株及其应用 Download PDFInfo
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- CN102703329B CN102703329B CN 201210167132 CN201210167132A CN102703329B CN 102703329 B CN102703329 B CN 102703329B CN 201210167132 CN201210167132 CN 201210167132 CN 201210167132 A CN201210167132 A CN 201210167132A CN 102703329 B CN102703329 B CN 102703329B
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- diosgenin
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- saponin
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- fusarium proliferatum
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- WQLVFSAGQJTQCK-UHFFFAOYSA-N diosgenin Natural products CC1C(C2(CCC3C4(C)CCC(O)CC4=CCC3C2C2)C)C2OC11CCC(C)CO1 WQLVFSAGQJTQCK-UHFFFAOYSA-N 0.000 title claims abstract description 29
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- 150000007949 saponins Chemical class 0.000 title claims abstract description 8
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- 244000062245 Hedychium flavescens Species 0.000 claims description 13
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims description 7
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
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- 238000006243 chemical reaction Methods 0.000 abstract description 9
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- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 description 8
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
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- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 4
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- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 4
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- SURQXAFEQWPFPV-UHFFFAOYSA-L iron(2+) sulfate heptahydrate Chemical compound O.O.O.O.O.O.O.[Fe+2].[O-]S([O-])(=O)=O SURQXAFEQWPFPV-UHFFFAOYSA-L 0.000 description 4
- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 4
- WRUGWIBCXHJTDG-UHFFFAOYSA-L magnesium sulfate heptahydrate Chemical compound O.O.O.O.O.O.O.[Mg+2].[O-]S([O-])(=O)=O WRUGWIBCXHJTDG-UHFFFAOYSA-L 0.000 description 4
- 229940061634 magnesium sulfate heptahydrate Drugs 0.000 description 4
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- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 3
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- DPDMMXDBJGCCQC-UHFFFAOYSA-N [Na].[Cl] Chemical compound [Na].[Cl] DPDMMXDBJGCCQC-UHFFFAOYSA-N 0.000 description 3
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 3
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 3
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- 239000004382 Amylase Substances 0.000 description 1
- 102000013142 Amylases Human genes 0.000 description 1
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- 241000228212 Aspergillus Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
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- 235000019418 amylase Nutrition 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 230000000703 anti-shock Effects 0.000 description 1
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- 229940111205 diastase Drugs 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 206010014599 encephalitis Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
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CN 201210167132 CN102703329B (zh) | 2012-05-28 | 2012-05-28 | 一株高效转化黄姜中皂苷生产薯蓣皂苷元的菌株及其应用 |
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CN 201210167132 CN102703329B (zh) | 2012-05-28 | 2012-05-28 | 一株高效转化黄姜中皂苷生产薯蓣皂苷元的菌株及其应用 |
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CN102703329A CN102703329A (zh) | 2012-10-03 |
CN102703329B true CN102703329B (zh) | 2013-10-23 |
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Publication number | Priority date | Publication date | Assignee | Title |
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CN103114047B (zh) * | 2013-02-03 | 2014-09-24 | 江南大学 | 一株高效转化黄姜皂苷的菌株及其应用 |
CN103103154B (zh) * | 2013-02-03 | 2014-08-27 | 江南大学 | 一株高效转化黄姜皂苷为薯蓣皂苷元的菌种及其应用 |
CN104232724A (zh) * | 2014-07-11 | 2014-12-24 | 华南理工大学 | 一种微生物转化法制备黄姜薯蓣皂素的方法 |
CN112322687B (zh) * | 2017-04-05 | 2022-02-11 | 中国医学科学院医药生物技术研究所 | 用于制备薯蓣皂苷元的菌剂及其应用 |
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CN101270337A (zh) * | 2008-05-21 | 2008-09-24 | 中国农业大学 | 一种利用盾叶薯蓣内生镰孢菌寡糖提高培养细胞薯蓣皂苷元产率的方法 |
CN102154123B (zh) * | 2011-03-16 | 2013-04-10 | 都晓伟 | 穿龙薯蓣内生真菌及其应用 |
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PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C53 | Correction of patent of invention or patent application | ||
CB03 | Change of inventor or designer information |
Inventor after: Shi Jinsong Inventor after: Ma Yang Inventor after: Zhang Jiajia Inventor after: Li Heng Inventor after: Li Hui Inventor after: Zhang Dandan Inventor after: Xu Zhenghong Inventor before: Shi Jinsong Inventor before: Zhang Jiajia Inventor before: Li Heng Inventor before: Li Hui Inventor before: Zhang Dandan Inventor before: Xu Zhenghong |
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COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: SHI JINSONG ZHANG JIAJIA LI HENG LI HUI ZHANG DANDAN XU ZHENGHONG TO: SHI JINSONG MA YANG ZHANG JIAJIA LI HENG LI HUI ZHANG DANDAN XU ZHENGHONG |
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C14 | Grant of patent or utility model | ||
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CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20131023 |