CN102702198B - 一种咖啡因甲化母液清洁处理的工艺及其设备 - Google Patents
一种咖啡因甲化母液清洁处理的工艺及其设备 Download PDFInfo
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- CN102702198B CN102702198B CN201210186868.6A CN201210186868A CN102702198B CN 102702198 B CN102702198 B CN 102702198B CN 201210186868 A CN201210186868 A CN 201210186868A CN 102702198 B CN102702198 B CN 102702198B
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- caffeine
- mother liquor
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- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 title claims abstract description 85
- 229960001948 caffeine Drugs 0.000 title claims abstract description 85
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 title claims abstract description 85
- 239000012452 mother liquor Substances 0.000 title claims abstract description 71
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- MLIREBYILWEBDM-UHFFFAOYSA-N cyanoacetic acid Chemical compound OC(=O)CC#N MLIREBYILWEBDM-UHFFFAOYSA-N 0.000 description 16
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 15
- 229960001701 chloroform Drugs 0.000 description 12
- 238000000746 purification Methods 0.000 description 11
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 10
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- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 2
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- 229960000278 theophylline Drugs 0.000 description 2
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- 241001284615 Frangula californica Species 0.000 description 1
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- 238000005554 pickling Methods 0.000 description 1
- ZFBGNQYKWSPQDQ-UHFFFAOYSA-N piperazine;sodium Chemical compound [Na].C1CNCCN1 ZFBGNQYKWSPQDQ-UHFFFAOYSA-N 0.000 description 1
- QHTPSODXPLCXJB-UHFFFAOYSA-N piperazine;urea Chemical class NC(N)=O.C1CNCCN1 QHTPSODXPLCXJB-UHFFFAOYSA-N 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
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- 239000002699 waste material Substances 0.000 description 1
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
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CN201210186868.6A CN102702198B (zh) | 2012-06-07 | 2012-06-07 | 一种咖啡因甲化母液清洁处理的工艺及其设备 |
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CN201210186868.6A CN102702198B (zh) | 2012-06-07 | 2012-06-07 | 一种咖啡因甲化母液清洁处理的工艺及其设备 |
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CN102702198A CN102702198A (zh) | 2012-10-03 |
CN102702198B true CN102702198B (zh) | 2014-05-28 |
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CN104478148A (zh) * | 2014-12-05 | 2015-04-01 | 山东新华制药股份有限公司 | 咖啡因成品母液的处理工艺 |
CN115572296B (zh) * | 2022-09-20 | 2023-11-21 | 青岛科技大学 | 一种降低咖啡因制品吸光度指数的方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2737793A1 (de) * | 1977-08-22 | 1979-03-08 | Peter Siegfried | Verfahren zur entcoffeinierung von rohkaffee |
CN101704818A (zh) * | 2009-12-22 | 2010-05-12 | 陈学玺 | 甲化母液吸附分离提取咖啡因的方法 |
CN201520670U (zh) * | 2009-09-16 | 2010-07-07 | 石药集团新诺威制药股份有限公司 | 一种咖啡因含氰废水的处理装置 |
CN101781066A (zh) * | 2010-03-23 | 2010-07-21 | 哈尔滨工业大学 | 咖啡因生产废水的处理方法 |
-
2012
- 2012-06-07 CN CN201210186868.6A patent/CN102702198B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2737793A1 (de) * | 1977-08-22 | 1979-03-08 | Peter Siegfried | Verfahren zur entcoffeinierung von rohkaffee |
CN201520670U (zh) * | 2009-09-16 | 2010-07-07 | 石药集团新诺威制药股份有限公司 | 一种咖啡因含氰废水的处理装置 |
CN101704818A (zh) * | 2009-12-22 | 2010-05-12 | 陈学玺 | 甲化母液吸附分离提取咖啡因的方法 |
CN101781066A (zh) * | 2010-03-23 | 2010-07-21 | 哈尔滨工业大学 | 咖啡因生产废水的处理方法 |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: SHANDONG XINHUA PHARMACEUTICAL CO., LTD. Effective date: 20130502 |
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C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20130502 Address after: 266061 Shandong Province, Qingdao city Laoshan District Songling Road No. 99 Applicant after: Qingdao University of Science & Technology Applicant after: Shandong Xinhua Pharmaceutical Co., Ltd. Address before: 266061 Shandong Province, Qingdao city Laoshan District Songling Road No. 99 Applicant before: Qingdao University of Science & Technology |
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