CN102696883B - Feed additive and application of feed additive - Google Patents

Feed additive and application of feed additive Download PDF

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Publication number
CN102696883B
CN102696883B CN201210168684.7A CN201210168684A CN102696883B CN 102696883 B CN102696883 B CN 102696883B CN 201210168684 A CN201210168684 A CN 201210168684A CN 102696883 B CN102696883 B CN 102696883B
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feed
feed additive
animal
addictive
lauric monoglyceride
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CN102696883A (en
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冯凤琴
宋飞
张辉
袁祎琳
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Hangzhou Kangyuan Food Science & Technology Co Ltd
Zhejiang University ZJU
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Hangzhou Kangyuan Food Science & Technology Co Ltd
Zhejiang University ZJU
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Abstract

The invention discloses a feed additive and an application of the feed additive. The feed additive comprises the following ingredients in percentage by weight: 20 to 60 percent of monoglyceride laurate, 10 to 40 percent of calcium propionate and 0 to 50 percent of feed carriers. The feed additive disclosed by the invention is added into feed raw materials, the feed is prepared in a stirring mixing or extruding granulation mode, the growth propagation of mycetes can be effectively inhabited, the storage period of the feed in the damp and hot season is prolonged, and in addition, the effects of inhabiting the bacteria, resisting viruses, reducing the use of antibiotics in the feed, promoting the animal growth and improving the animal survival rate and the disease resistance capability are realized; and meanwhile, the feed additive has the advantages that the cost is low, the process is simple, the operation is convenient, the safety is high, and the feed additive is suitable for practical production.

Description

A kind of feed addictive and application thereof
Technical field
The present invention relates to feed additive field, particularly relate to a kind of feed addictive and application thereof.
Background technology
There are two most distinct issues in current China feedstuff industry: (1) feed is mouldy.Especially in the south of humidity, the shelf-life of feed only has more than ten day, even if with the addition of conventional mould inhibitor calcium propionate, effect is also undesirable.(2) antibiotic abuse.Although add the survival rate that antibiotic can improve brood in feed, and play growth promoting effects effect to letting animals feed, the food-safety problems such as the resistance to the action of a drug can be caused.Although the Ministry of Agriculture has prohibited the application of multiple powerful antibiotic in feed, but once arrive disease multiple season, owing to being difficult to find bacteriostatic agent more more effective than antibiotic at present on the market, even if Feed Manufacturing manufacturer does not add, cultivation factory staff still can add antibiotic to ensure the survival rate of animal in feed.Therefore, develop efficient, safe Midew preventive for feed and antivirus somatotropic agent, be feed additive industry trend of the times (Zhang Qi .2010. China pig feed industry market As-Is analysis and prediction. feed wide-angle, 4,14-16.).
Except mould inhibitor and antivirus somatotropic agent, in some special animal feeds are as pig starter feed, also generally add food emulsifier, its main purpose: one is the digestibility improving feed fat, and then reach the object promoting piglet growth, improve breeding performonce fo animals.Because feed fat is in the alimentary canal of animal, first chylomicron must be emulsified into, could absorb in digested road afterwards, but weanling pig gut development is incomplete, bile salt and lipase hyposecretion, be difficult to carry out good emulsification and absorption (Cera KR to fat, Mahan DC, Cross RF, Reinhart GA, Whitmoyer RE.1988.Effect of age, weaning and postweaning diet on small intestinal growth and jejunal morphology in young swine.Journal of Animal Science, 66, 574-584., Li DF, Thaler RC, Nelssen JL, Harmon DL, Allee GL, Weeden TL.1990.Effect of fat sources and combinations on starter pig performance, nutrient digestibility and intestinal morphology.Journal of Animal Science, 68,3694-3704.), and emulsifying agent can promote or accelerate the emulsification of fat, be conducive to the absorption and digestion of fat.Two is make an addition in substitute breast milk, to ensure being uniformly distributed of various nutritional labeling (especially liposoluble constituent) in substitute breast milk.Three is in the feed processing technology sprayed afterwards in employing, can ensure lipid material being uniformly distributed in spray coating liquor, strengthen atomizing effect, improve coating quality.
Lauric monoglyceride is natural to be present in human milk, also be the intermediate product of coconut oil metabolism in vivo, derive from the lauric monoglyceride that the laurate of natural oil and glycerine obtain through esterification, its 26S Proteasome Structure and Function is identical with naturally occurring, the safety of generally acknowledging in the world, nontoxic, polyfunctional food additive, there is excellent emulsification function and broad-spectrum antibacterial activity, be widely used in varieties of food items, in cosmetics and medical product, that the GRAS(of U.S. FDA identification It is generally accepted safety) based food additive, also be the security classes additive of ministry of Health of China approved for varieties of food items.Domestic and international the experimental results shows, lauric monoglyceride has good inhibitory action (see table 1) to common animals pathogenic bacteria such as staphylococcus aureus, streptococcus, Listeria, Bacillus cereus, can also suppress the mould such as aspergillus niger, mould and protozoic growth and breeding.Long-term absorption lauric monoglyceride can not produce drug resistance, also micro-ecological environment (the Isaacs CE of animal intestinal can not be destroyed, Thormar is role of milkderived antimicrobial lipids as antiviral and antibacterial agents.Advances in Experimental Medicine and Biology H.1991.The, 310, 159-165.), and also have certain effect (Kabara JJ.1993.Medium-chain fatty acids and esters.In:Davidson PM to raising animal body immunity, Branen JK, editors.Antimicrobials in foods.2nd ed.New York:Marcel Dekker Inc.).
Table 1 lauric monoglyceride is to the minimum inhibitory concentration (μ g/ml) of common pathogen
Strain name pH=5.7 pH=7.2
Listeria monocytogenes 12.5 12.5
Staphylococcus aureus 8.0 12.5
Streptococcus fecalis 12.5 25.0
Beta hemolytic streptococcus - 12.50
Bacillus cereus - 25.0
Especially, lauric monoglyceride can also suppress or stop influenza virus, respiratory system syncytiam virus (Charles E.I.et al.1995), herpes simplex virus, blister stomatitis virus (Halldor Thormar et al.1987) and people's immunodeficiency virus (Qingsheng Li etc., Glycerol monolaurate prevents mucosal SIV transmission, Nature, Vol 458,2009) infection to animal body such as, plays prevention and auxiliary therapeutic action to animal viral disease.
Summary of the invention
The invention provides a kind of feed addictive, make an addition in animal feed, feed mold, emulsified fat can be prevented, and reduce antibiotic use, highly effective and safe; With this feed feeding animals, animal digesting and assimilating feed can be promoted, prevent and treat viral disease, promote growth of animal, improve animal immunizing power and survival rate.
A kind of feed addictive, by weight percentage, comprising:
Lauric monoglyceride 20-60%
Calcium propionate 10-40%
Feed vector 0-50%.
Lauric monoglyceride has fungus-resistant, antiviral functions; Meanwhile, or a kind of excellent food emulsifying agent, the digestibility of feed fat can be improved; And laurate belongs to medium chain fatty acid, there is the metabolic pathway in animal body different from LCFA, can the digested absorption of speed faster, realize the object of quick energy supply, this to brood grow and the raising of survival rate particularly important.
Calcium propionate is conventional Midew preventive for feed, its effective form really playing mildew-proof function is propionic acid, therefore must after sour environment calcium propionate be converted into propionic acid, just can there is good anti-mold effect (Yin Yan, Li Chenbo, Zeng Yelin, Wang Tian .2011. calcium propionate and the application in animal productiong thereof. feed industry, 32,15-17.).And lauric monoglyceride does not have dissociation, its fungistatic effect is hardly by the impact of pH change, all effective in pH4-8 scope.Two kinds of raw materials according to the above ratio with the use of, good synergy can be played.
Preferably, by weight percentage, described feed addictive comprises:
Lauric monoglyceride 30-55%
Calcium propionate 15-35%
Feed vector 20-50%.
More preferably, by weight percentage, described feed addictive comprises:
Lauric monoglyceride 30-40%
Calcium propionate 15-20%
Feed vector 40-50%.
Calcium propionate is typical ionic mould inhibitor, can dissolve completely in water, is reduced into propanoic acid molecules and acts on fungal cell and play a role in slant acidity environment; And lauric monoglyceride is nonionic mould inhibitor, in water, solubility is lower, is slowly scattered in water plays bacteria mildew-proof effect with molecular forms.According to each material rate formula feed additive of this preferred version, the synergistic function of lauric monoglyceride and calcium propionate is best.
The monoester content of described lauric monoglyceride is preferably 40-95%.Lauric monoglyceride is generally that laurate and glycerine synthesized by esterification under certain condition, diester and the generation of three esters is often attended by its course of reaction, diester and three esters do not have bacteriostasis, and monoesters has been the main component of mildew-proof function, therefore, the lauric monoglyceride that monoester content is higher can play better mildew-proof function.
The particle diameter of described lauric monoglyceride is preferably 20-100 order, and the lauric monoglyceride of this particle size range is conducive to dispersed in feed and digesting and assimilating in animal intestinal, effectively can improve the biologically active of feed addictive.Described calcium propionate or the particle diameter of feed vector are preferably 20-100 order, are beneficial to mixing between raw material.
Described feed vector can be soluble carrier or insoluble carrier; Wherein, soluble carrier can be at least one in maltodextrin, glucose and soluble starch; Insoluble carrier can be at least one in corncob material, albumen powder, wheatfeed, oily chaff, rice bran and zeolite powder.Feed vector can carry active component (lauric monoglyceride and calcium propionate), is conducive to lauric monoglyceride and is uniformly dispersed in feed, and have good chemical stability and adsorptivity, and it is Edible material.
Described feed addictive can be prepared by the following method: raw material being crushed to respectively particle diameter is 20-100 order, mixes, obtains feed addictive.
Present invention also offers a kind of animal feed, containing above-mentioned feed addictive.This animal feed not easily goes mouldy, grease emulsifying is effective, highly effective and safe, does not need to add antibiotic and can be directly used in feeding animals, can effectively improve animal immunizing power and survival rate, prevent and treat viral disease, promote growth of animal.
Described animal feed can be domestic animals and fowls feed or aquatic animal feed, and domestic animals and fowls can be pig, chicken or duck, and aquatic livestock can be fish or shrimps; Be preferably the aquatic livestock of immature domestic animals and fowls or easily morbidity; The fish being more preferably immature pig, chicken or easily falling ill.Test proves, compares adults, and feed addictive of the present invention is better to the diseases prevention of the aquatic livestock of immature domestic animals and fowls or easily morbidity, growth-promoting effect.
The addition of described feed addictive in animal feed is preferably 0.1-0.4% by weight percentage.Can reach good mildew-resistant, diseases prevention, growth-promoting effect under this addition, and mouthfeel is suitable, animal capable accepts, and does not affect animal and normally takes food.
Present invention also offers a kind of preparation method of animal feed, comprising: above-mentioned feed addictive is added in feedstuff, by be uniformly mixed or extruder grain mode obtains animal feed.Preferably, extruder grain mode is adopted to prepare described animal feed.The treatment temperature of extruder grain mode is higher, adopts which, is conducive to the higher lauric monoglyceride of fusing point and dissolves better, be scattered in animal feed.
Described extruder grain can adopt comminutor to carry out.
The present invention for primary raw material, take feed vector as auxiliary material, according to the composite obtained feed addictive of suitable ratio with lauric monoglyceride and calcium propionate.According to correlation test result, in damp and hot season, under normal temperature, after the feed being added with feed addictive of the present invention is preserved 45 days, fungi count all specify lower than " forage health standard GB 13078-2001 " 4.5 × 10 4; Do not adding under any antibiotic condition, institute's domesticated animal hair color, the incidence of disease and weightening finish all significantly improve than the contrast not adding feed addictive of the present invention.Meanwhile, result of the test shows, by lauric monoglyceride and the composite use of calcium propionate, can produce good synergistic function.
Raw materials of feed additives of the present invention is easy to get, prepare simple, security is good; Made an addition in feed, had concurrently the function of Midew preventive for feed, antivirus somatotropic agent, emulsifying agent, namely be there is fungus-resistant, emulsified fat, minimizing even eliminated the several functions such as antibiotic usage, the few but Be very effective of use amount; Adopt the feed being added with this feed addictive to feed and raise animal, animal effectively can be promoted the digesting and assimilating of feed (particularly feed fat), improve animal immunizing power (particularly effectively can prevent and treat viral disease), promote growth of animal, and effectively improve the survival rate of animal, be particularly useful for the aquatic livestocks such as the fish of the domestic animals and fowls animals such as immature pig, chicken or easily morbidity.
Detailed description of the invention
According to the following example, the present invention may be better understood.But the material proportion described by embodiment and the implementation result on different animals only for illustration of the present invention, and should can not limit the present invention described in detail in claims yet.
Embodiment 1
In the present embodiment, the weight ratio of lauric monoglyceride (monoester content is 70%), calcium propionate and feed vector (maltodextrin) is 3:2:5.
(1) each raw material being all crushed to particle diameter is 30 orders, then mixes according to aforementioned proportion, obtains feed addictive;
(2) feed addictive is joined in the feedstuff (formula and nutritional labeling are in table 2) of pig starter feed with 0.1% addition, then carry out extruder grain by comminutor, obtained pig starter feed.
Comparative example 1 does not add feed addictive, directly the feedstuff of pig starter feed is carried out extruder grain by comminutor, obtained pig starter feed.
Comparative example 2 substitutes feed addictive with Bacitracin Zinc, joins in the feedstuff of pig starter feed according to 50mg/kg addition, then carries out extruder grain by comminutor, obtained pig starter feed.
Mildew test and result
After the pig starter feed of comparative example 1 is stored 45 days summer, mould assay is 1.2 × 10 5.After the pig starter feed of embodiment 1 is stored 45 days summer, find that feed does not go mouldy, mould assay is 2.2 × 10 4(lower than " forage health standard GB 13078-2001 " specifies 4.5 × 10 4).Show that the feed addictive of embodiment 1 can effectively prevent pig starter feed from going mouldy.
Animal experiment and result
In swine disease multiple season, to feed respectively weanling pig 1 month with the pig starter feed of comparative example 1-2 and embodiment 1.Result shows, and adopts the pig starter feed of embodiment 1, and piglet feed is normal, hair color light, ight soil is fine and smooth, does not have punishment in advance phenomenon, and the speed of growth is accelerated, build elongates obviously, the incidence of disease and weightening finish all close with the piglet of comparative example 2 (checking through t, p>0.05).Meanwhile, compare ratio 1, piglet daily gain improves 15%, and feed conversion rate improves 20%.Show to adopt the feed addictive of embodiment 1 can reach the result of use of common antibiotics Bacitracin Zinc, and greatly reduce antibiotic use, obtained feed highly effective and safe more, effectively can promote piglet growth.
Table 2 piglet diet (feedstuff) formula and nutritional labeling
Embodiment 2
In the present embodiment, the weight ratio 3:3:4 of lauric monoglyceride (monoester content is 90%), calcium propionate and feed vector (rice bran).
(1) each raw material being all crushed to particle diameter is 30 orders, then mixes according to aforementioned proportion, obtains feed addictive;
(2) feed addictive is joined in chicken feed (formula and nutritional labeling are in table 3 and table 4) with 0.2% addition, then carry out extruder grain by comminutor, obtained chicken feed.
Comparative example 3 does not add feed addictive, directly the feedstuff of chicken feed is carried out extruder grain by comminutor, obtained chicken feed.
Comparative example 4 substitutes feed addictive with Bacitracin Zinc, joins in the feedstuff of chicken feed according to 80mg/kg addition, then carries out extruder grain by comminutor, obtained chicken feed.
Mildew test and result
After the chicken feed of comparative example 3 is stored 45 days summer, mould assay is 2.2 × 10 5.After the chicken feed of embodiment 2 is stored 45 days summer, find that feed does not go mouldy, mould assay is 3.6 × 10 4(lower than " forage health standard GB 13078-2001 " specifies 4.5 × 10 4).Show that the feed addictive of embodiment 2 can effectively prevent chicken feed from going mouldy.
Animal experiment and result
Feeding dorking and laying hen is distinguished with the chicken feed of comparative example 3-4 and embodiment 2.Result shows, and adopts the chicken feed of embodiment 2, and chicken feed is normal, weightening finish and the death rate all close with the chicken of comparative example 4 (checking through t, p>0.05).Meanwhile, compare ratio 3, the broiler chicken death rate on average declines 1%, and daily gain on average increases by 2.5%; Laying rate of laying hen improves 3.5%, and broken soft egg number reduces 1%, and inhibits the laying rate decrease speed of laying hen.Show to adopt the feed addictive of embodiment 2 can reach the result of use of common antibiotics Bacitracin Zinc, and greatly reduce antibiotic use, obtained feed highly effective and safe more, effectively can promote that chicken grows and lays eggs.
Table 3 daily ration of broiler (feedstuff) is filled a prescription
Table 4 layer diets (feedstuff) is filled a prescription
Embodiment 3
In the present embodiment, the weight ratio of lauric monoglyceride (monoester content is 40%), calcium propionate and feed vector (rice bran) is 7:3:10.
(1) each raw material being all crushed to particle diameter is 20 orders, then mixes according to aforementioned proportion, obtains feed addictive;
(2) feed addictive is joined in piglet feed (formula and nutritional labeling are in table 5) with 0.3% addition, then carry out extruder grain by comminutor, obtained piglet feed.
Comparative example 5 does not add feed addictive, directly the feedstuff of piglet feed is carried out extruder grain by comminutor, obtained piglet feed.
Comparative example 6 substitutes feed addictive with Bacitracin Zinc, joins in the feedstuff of piglet feed according to 50mg/kg addition, then carries out extruder grain by comminutor, obtained piglet feed.
Mildew test and result
After the piglet feed of comparative example 5 is stored 45 days summer, mould assay is 1.7 × 10 5.After the piglet feed of embodiment 3 is stored 45 days summer, find that feed does not go mouldy, mould assay is 9.0 × 10 3(lower than " forage health standard GB 13078-2001 " specifies 4.5 × 10 4).Show that the feed addictive of embodiment 3 can effectively prevent piglet feed from going mouldy.
Animal experiment and result
In swine disease multiple season, to feed respectively piggy 1 month with the piglet feed of comparative example 5-6 and embodiment 3.Result shows, and adopts the piglet feed of embodiment 3, and piggy feed is normal, hair color light, without diarrhoea phenomenon, the incidence of disease and weightening finish all close with the piggy of comparative example 6 (checking through t, p>0.05).Meanwhile, compare ratio 5, piggy average daily gain improves 7%, and feed conversion rate improves 25%, within 10 days, delivers for sale in advance.Show to adopt the feed addictive of embodiment 3 can reach the result of use of common antibiotics Bacitracin Zinc, and greatly reduce antibiotic use, obtained feed highly effective and safe more, can effectively promote that piggy grows.
The little swine rations of table 5 (feedstuff) is filled a prescription
Embodiment 4
In the present embodiment, the weight ratio of lauric monoglyceride (monoester content is 70%), calcium propionate and feed vector (maltodextrin) is 3:2:5.
(1) each raw material being all crushed to particle diameter is 25 orders, then mixes according to aforementioned proportion, obtains feed addictive;
(2) feed addictive is joined in feed of grass carp (formula and nutritional labeling are in table 6) with 0.3% addition, then carry out extruder grain by comminutor, obtained feed of grass carp.
Comparative example 7 does not add feed addictive, directly the feedstuff of feed of grass carp is carried out extruder grain by comminutor, obtained feed of grass carp.
Comparative example 8 substitutes feed addictive with Bacitracin Zinc, joins in the feedstuff of feed of grass carp according to 50mg/kg addition, then carries out extruder grain by comminutor, obtained feed of grass carp.
Mildew test and result
After the feed of grass carp of comparative example 7 is stored 45 days summer, mould assay is 1.9 × 10 5.After the feed of grass carp of embodiment 4 is stored 45 days summer, find that feed does not go mouldy, mould assay is 7.9 × 10 3(lower than " forage health standard GB 13078-2001 " specifies 4.5 × 10 4).Show that the feed addictive of embodiment 4 can effectively prevent feed of grass carp from going mouldy.
Animal experiment and result
To feed respectively grass carp with the feed of grass carp of comparative example 7-8 and embodiment 4.Result shows, and adopts the feed of grass carp of embodiment 4, and fish feed is normal, weightening finish and survival rate all close with the fish of comparative example 8 (checking through t, p>0.05).Meanwhile, compare ratio 7, grass carp survival rate improves 7%, and average growth rate improves 12%, and efficiency of feed utilization improves 12%.Show to adopt the feed addictive of embodiment 4 can reach the result of use of common antibiotics Bacitracin Zinc, and greatly reduce antibiotic use, obtained feed highly effective and safe more, effectively can promote Growth of Grass Carps Ctenopharyngodon Idellus.
Table 6 grass carp daily ration (feedstuff) is filled a prescription

Claims (2)

1. a feed addictive, is characterized in that, preparation method is: the weight ratio of lauric monoglyceride, calcium propionate and maltodextrin is 3:2:5, and wherein, the monoester content in lauric monoglyceride is 70%;
It is 30 orders that each raw material is all crushed to particle diameter, then mixes according to aforementioned proportion, obtains feed addictive.
2. an animal feed, is characterized in that, preparation method is: joined in the feedstuff of pig starter feed with 0.1% addition by feed addictive as claimed in claim 1, then carries out extruder grain by comminutor, obtained pig starter feed; Wherein, formula and the nutritional labeling of described feedstuff are as shown in the table:
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Inventor after: Feng Fengqin

Inventor after: Jiang Zengliang

Inventor after: Song Fei

Inventor after: Zhang Hui

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Free format text: CORRECT: INVENTOR; FROM: FENG FENGQIN SONG FEI ZHANG HUI YUAN YILIN TO: FENG FENGQIN JIANG ZENGLIANG SONG FEI ZHANG HUI YUAN YILIN