CN102696625B - Sterilization composition containing difenoconazole and picoxystrobin and application of sterilization composition - Google Patents
Sterilization composition containing difenoconazole and picoxystrobin and application of sterilization composition Download PDFInfo
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- CN102696625B CN102696625B CN 201210224643 CN201210224643A CN102696625B CN 102696625 B CN102696625 B CN 102696625B CN 201210224643 CN201210224643 CN 201210224643 CN 201210224643 A CN201210224643 A CN 201210224643A CN 102696625 B CN102696625 B CN 102696625B
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- CN
- China
- Prior art keywords
- bactericidal composition
- zen
- bactericide
- phenylate
- azoles
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 59
- 230000001954 sterilising effect Effects 0.000 title abstract description 5
- 239000005818 Picoxystrobin Substances 0.000 title abstract description 3
- IBSNKSODLGJUMQ-SDNWHVSQSA-N picoxystrobin Chemical compound CO\C=C(\C(=O)OC)C1=CC=CC=C1COC1=CC=CC(C(F)(F)F)=N1 IBSNKSODLGJUMQ-SDNWHVSQSA-N 0.000 title abstract description 3
- 238000004659 sterilization and disinfection Methods 0.000 title abstract 4
- 239000005760 Difenoconazole Substances 0.000 title abstract 2
- BQYJATMQXGBDHF-UHFFFAOYSA-N difenoconazole Chemical compound O1C(C)COC1(C=1C(=CC(OC=2C=CC(Cl)=CC=2)=CC=1)Cl)CN1N=CN=C1 BQYJATMQXGBDHF-UHFFFAOYSA-N 0.000 title abstract 2
- 241000209140 Triticum Species 0.000 claims abstract description 48
- 235000021307 Triticum Nutrition 0.000 claims abstract description 46
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims abstract description 23
- 241000221785 Erysiphales Species 0.000 claims abstract description 20
- 230000000844 anti-bacterial effect Effects 0.000 claims description 49
- 150000003851 azoles Chemical class 0.000 claims description 35
- 239000003899 bactericide agent Substances 0.000 claims description 16
- 239000012752 auxiliary agent Substances 0.000 claims description 9
- 239000000375 suspending agent Substances 0.000 claims description 9
- 239000000839 emulsion Substances 0.000 claims description 7
- 239000004480 active ingredient Substances 0.000 claims description 6
- 239000004530 micro-emulsion Substances 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 238000009736 wetting Methods 0.000 claims description 6
- 239000003905 agrochemical Substances 0.000 claims description 4
- 239000004562 water dispersible granule Substances 0.000 claims description 4
- 201000010099 disease Diseases 0.000 abstract description 23
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 23
- 239000000575 pesticide Substances 0.000 abstract description 6
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- 238000002360 preparation method Methods 0.000 description 36
- 239000003814 drug Substances 0.000 description 31
- 230000003902 lesion Effects 0.000 description 20
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 15
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- 210000000481 breast Anatomy 0.000 description 14
- 239000000047 product Substances 0.000 description 13
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- 239000002270 dispersing agent Substances 0.000 description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 10
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- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid group Chemical group C(C1=CC=CC=C1)(=O)O WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 8
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- 229910019142 PO4 Inorganic materials 0.000 description 7
- -1 alkyl naphthalene sulfonic acid salt Chemical class 0.000 description 7
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 7
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- 238000000034 method Methods 0.000 description 7
- 239000010452 phosphate Substances 0.000 description 7
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 6
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 6
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- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical group CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 235000012211 aluminium silicate Nutrition 0.000 description 4
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 4
- 235000010233 benzoic acid Nutrition 0.000 description 4
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- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 4
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- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- 229920001732 Lignosulfonate Polymers 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical group OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 206010039509 Scab Diseases 0.000 description 3
- 150000008051 alkyl sulfates Chemical class 0.000 description 3
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- 239000004202 carbamide Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
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- PSZYNBSKGUBXEH-UHFFFAOYSA-M naphthalene-1-sulfonate Chemical compound C1=CC=C2C(S(=O)(=O)[O-])=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-M 0.000 description 3
- 229920005646 polycarboxylate Polymers 0.000 description 3
- PYODKQIVQIVELM-UHFFFAOYSA-M sodium;2,3-bis(2-methylpropyl)naphthalene-1-sulfonate Chemical compound [Na+].C1=CC=C2C(S([O-])(=O)=O)=C(CC(C)C)C(CC(C)C)=CC2=C1 PYODKQIVQIVELM-UHFFFAOYSA-M 0.000 description 3
- LRWZZZWJMFNZIK-UHFFFAOYSA-N 2-chloro-3-methyloxirane Chemical compound CC1OC1Cl LRWZZZWJMFNZIK-UHFFFAOYSA-N 0.000 description 2
- 241001480061 Blumeria graminis Species 0.000 description 2
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- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
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- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 2
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- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
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- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 description 1
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- DMAXMXPDVWTIRV-UHFFFAOYSA-N 2-(2-phenylethyl)phenol Chemical compound OC1=CC=CC=C1CCC1=CC=CC=C1 DMAXMXPDVWTIRV-UHFFFAOYSA-N 0.000 description 1
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- 229940054066 benzamide antipsychotics Drugs 0.000 description 1
- 150000003936 benzamides Chemical class 0.000 description 1
- DMSMPAJRVJJAGA-UHFFFAOYSA-N benzo[d]isothiazol-3-one Chemical compound C1=CC=C2C(=O)NSC2=C1 DMSMPAJRVJJAGA-UHFFFAOYSA-N 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
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- RYAGRZNBULDMBW-UHFFFAOYSA-L calcium;3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Ca+2].COC1=CC=CC(CC(CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O RYAGRZNBULDMBW-UHFFFAOYSA-L 0.000 description 1
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Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to a sterilization composition and an application thereof. The sterilization composition contains difenoconazole and picoxystrobin, and is used for preventing wheat powdery mildew and rust disease. The composition has an obvious synergistic effect on preventing agricultural diseases as compared with a single pesticide, and is contributed to overcoming and postponing the generation of pesticide resistance of bacteria.
Description
[technical field]
The invention belongs to technical field of pesticide.More specifically, the present invention relates to a kind of bactericidal composition that contains the two azoles of phenylate and ZEN 90160, also relate to the purposes of described bactericidal composition.
[background technology]
Wheat powdery mildew and rust are the important diseases on Wheat Production, can cause heavy losses to Wheat Production.Wheat powdery mildew (Blumeria graminis) is a kind of worldwide disease, in each main wheat producing countries, distribution is arranged all, and China's Along The Coast of Shandong Province, Sichuan, Guizhou, Yunnan occur general, causes harm also heavy.In recent years should disease northeastward, North China, northwest Mai Qu, the gesture that is on the rise is also arranged.This disease can be encroached on each organ of wheat plant overground part, but take blade and leaf sheath as main, when morbidity is heavy, grain husk shell and awns also can be injured.All can cause harm to the strain phase in seedling stage, main harm blade, the leaf sheath of also can causing harm when serious, stem stalk and fringe section.General face of blade scab is more than reverse side, and lower blade can heal when scab is many in flakes more than upper blade.And cause yellow leaf withered.After stem stalk and leaf sheath were injured, plant easily lodged; Wheat rust is again jaundice, and 3 kinds of yellow rust, black stem rust and leaf rust are arranged.That on China's Wheat Production, distribution is wide, propagation is fast, the important disease that hazard area is large.Wherein occur the most general and serious with stripe rust of wheat.After wheat generation rust, in body, nutrient is absorbed, and chlorophyll is destroyed, and a large amount of soruss are broken through wheat leaf, straw epidermis, have a strong impact on yield and quality of wheat.
The inventor studies discovery, bactericidal composition take the two azoles of phenylate and ZEN 90160 as active ingredient, be used for the control of wheat powdery mildew and rust, can delay the drug-fast generation of germ, improve actual preventive effect, enlarging fungicidal spectrum and reduce drug cost, is the important means of wheat diseases integrated control.
[summary of the invention]
[technical problem that will solve]
The purpose of this invention is to provide a kind of bactericidal composition that contains the two azoles of phenylate and ZEN 90160.
Another object of the present invention is to provide the purposes of described bactericidal composition.
[technical scheme]
The present invention is achieved through the following technical solutions.
The present invention relates to a kind of bactericidal composition that contains the two azoles of phenylate and ZEN 90160.This bactericidal composition contains following active component A and B:
A is the two azoles of phenylate with following structural formula:
The two azoles of phenylate (English common name: Difenodiconazole), chemical name: 2-[2-chloro-4-(4-chlorobenzene oxygen) phenyl]-1, two (1H-1,2,4-the triazol-1-yl)-2-propyl alcohol of 3-.CN 200610140836.7 discloses chemical structural formula, preparation method and the sterilizing use of the two azoles of phenylate, in present specification, this patent application is incorporated herein by reference in full.
B is ZEN 90160;
ZEN 90160 (Picoxystrobin) is the methoxy acrylic bactericide by Syngenta Co.,Ltd's exploitation, and a kind of mitochondrial respiratory inhibitor namely shifts by electronics between cytochrome b and C1 and suppresses mitochondrial breathing.Control is effective to the bacterial strain that 14-demethylation enzyme inhibitor, benzamides, three carboxyl acylamides and benzimidazole produce resistance.Have systemic activity and fumigation activity preferably, after dispenser, active ingredient can effectively be reallocated and fully be transmitted, so ZEN 90160 extremely has better therapeutic activity than commercial Fluoxastrobin and oxime bacterium.After crop was processed with ZEN 90160, output was high, quality good, particle is large and full.Be mainly used in preventing and treating the foliage disease of wheat class such as leaf blight, leaf rust, glume blight, brown spot, powdery mildew etc.
In this bactericidal composition, the weight ratio of component A and B component is 1:100 ~ 100:1.
Preferably, in this bactericidal composition, the weight ratio of component A and B component is 1:50～50:1.
More preferably, in this bactericidal composition, the weight ratio of component A and B component is 1:10～10:1.
The invention still further relates to the purposes of described bactericidal composition in control wheat powdery mildew and rust.
The present invention relates to a kind of bactericide.
This bactericide contains 0.1～90 above-mentioned bactericidal composition of % by weight and surplus is acceptable carrier and auxiliary agent on agricultural chemicals.
Preferably, this bactericide contains 3～80 above-mentioned bactericidal compositions of % by weight.
More preferably, this bactericide contains 15～70 above-mentioned bactericidal compositions of % by weight.
Except as otherwise noted, " % " involved in the present invention is " percentage by weight ".
Bactericide involved in the present invention can be mixed with the upper acceptable formulation of agricultural, preferred dosage form is suspending agent, aqueous emulsion, microemulsion, wetting powder or water dispersible granules.All these formulations all adopt method as well known to those skilled in the art to prepare by acceptable carrier and auxiliary agent on above-mentioned bactericidal composition and agricultural chemicals.
As for suspending agent type, those skilled in the art can adopt conventional preparation method to be obtained by these auxiliary agent preparations of dispersant, wetting agent, thickener, preservative, defoamer and antifreezing agent.
Described dispersant is selected from polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate or TERSPERSE 2425(U.S. Huntsman Corporation produces, the alkyl naphthalene sulfonic acid salt).
Described wetting agent is selected from the poly-basic ether formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkylphenol-polyethenoxy base ether phosphate, phenethyl phenol polyethenoxy base ether phosphate, alkyl sulfate, alkylsulfonate, naphthalene sulfonate or TERSPERSE 2500(U.S. Huntsman Corporation produces).
Described thickener is selected from xanthans, aluminium-magnesium silicate or bentonite.
Described preservative is selected from benzoic acid, Sodium Benzoate or BIT(1, the 2-benzisothiazole-3-ketone).
Described defoamer is silicone based defoamer.
Described antifreezing agent is selected from ethylene glycol, propane diols, glycerine, urea or inorganic salts such as sodium chloride.
Dispersant, wetting agent, thickener, preservative, defoamer and the antifreezing agent that uses during suspending agent type in preparation is all product sold in the market.
As for Water emulsion, those skilled in the art can adopt conventional preparation method to be obtained by these the main auxiliary agent preparations of emulsifier, solvent, stabilizing agent, antifreezing agent, thickener and preservative.
Described emulsifier is selected from Nonyl pheno (EO=10) ether phosphate, triphen ethyl-phenol polyoxyethylene ether phosphate (agriculture breast 600# phosphate), Nongru-700 #, agriculture breast 2201#, Span-60#, emulsifier T-60, TX-10, agriculture breast 1601#, agriculture breast 600# or agriculture breast 400#.
Described solvent is selected from dimethylbenzene, toluene, cyclohexanone or solvent naphtha (trade mark: S-150, S-180, S-200).
Described stabilizing agent is selected from triphenyl phosphite or epoxychloropropane.
Described antifreezing agent is selected from ethylene glycol, propane diols, glycerine, urea or inorganic salts such as sodium chloride.
Described thickener is selected from xanthans, bentonite or aluminium-magnesium silicate.
Described preservative is selected from BIT(1, the 2-benzisothiazole-3-ketone), benzoic acid or Sodium Benzoate.
Emulsifier, solvent, stabilizing agent, antifreezing agent, thickener and the preservative that uses during Water emulsion in preparation is all product sold in the market.
As for microemulsion dosage, those skilled in the art can adopt conventional preparation method to be obtained by these the main auxiliary agent preparations of emulsifier, cosolvent, solvent and stabilizing agent.
Described emulsifier is selected from calcium dodecyl benzene sulfonate (agriculture breast 500#), Nongru-700 #, agriculture breast 2201#, this dish-60#, Tween-80, TX-10, agriculture breast 1601, agriculture breast 600# or agriculture breast 400#.
Described cosolvent is selected from methyl alcohol, isopropyl alcohol, n-butanol or ethanol.
Described solvent is selected from cyclohexanone, 1-METHYLPYRROLIDONE, dimethylbenzene, toluene or solvent naphtha (trade mark: S-150, S-180, S-200).
Described stabilizing agent is selected from triphenyl phosphite or epoxychloropropane.
Emulsifier, cosolvent, solvent and the stabilizing agent that uses during microemulsion dosage in preparation is all product sold in the market.
As for the water-dispersible grain formulation, those skilled in the art can adopt conventional preparation method to be obtained by these the main auxiliary agent preparations of dispersant, wetting agent, disintegrant, binding agent and filler.
Described dispersant is selected from polycarboxylate, lignosulfonates or alkylnaphthalene sulfonate.
Described wetting agent is selected from polyoxyethylene alcohol, alkyl sulfate, alkylsulfonate or naphthalene sulfonate.
Described disintegrant is selected from ammonium sulfate, urea, sucrose, glucose, citric acid, succinic acid or sodium bicarbonate.
Described binding agent is selected from diatomite, corn starch, PVA, carboxymethyl (ethyl) cellulose family and microcrystalline cellulose class.
Described filler is selected from diatomite, kaolin, white carbon, fine particle calcium carbonate, sepiolite, talcum powder, attapulgite or potter's clay etc.
Dispersant, wetting agent, disintegrant, binding agent and the filler that uses when preparation water-dispersible grain formulation is all product sold in the market.
As for the wettable powder formulation, those skilled in the art can adopt conventional preparation method to be obtained by the main auxiliary agent preparation of dispersant, wetting agent and filler.
Described dispersant is selected from polycarboxylate, lignosulfonates or alkylnaphthalene sulfonate.
Described wetting agent is selected from alkyl sulfate, alkylsulfonate or naphthalene sulfonate.
Described filler is selected from diatomite, kaolin, white carbon, fine particle calcium carbonate, talcum powder, attapulgite or potter's clay etc.
Dispersant, wetting agent and the filler that uses when preparation wettable powder formulation is all product sold in the market.
Bactericidal composition of the present invention can provide with the finished product preparation form, and namely in composition, each material mixes; Also can provide with the single dose preparation, directly mix in bucket (tank) before using.Concentrate of the present invention usually and water be mixed to get the concentration of required active substance.
The invention still further relates to a kind of method of preventing and treating the wheat crop disease, before or after the wheat crop introduced disease, use above-mentioned bactericidal composition of the present invention or bactericide to the place of wheat and growth or storage.Application process is the conventional application process of agricultural chemicals, such as pouring, injection, spraying, dusting, broadcast sowing etc.
[beneficial effect]
The invention has the beneficial effects as follows:
(1) compare with single dose, bactericidal composition of the present invention has significant synergistic effect to disease, has improved bactericidal effect;
(2) reduce the medication number of times, reduce drug cost, environmental contamination reduction and residue of pesticide;
(3) composition is comprised of the active ingredient of different mechanism of action, and action site increases, and is conducive to overcome and delays the drug-fast generation of germ.
[embodiment]
Can understand better the present invention by following embodiment.The ratio of the active ingredient that relates in the application if no special instructions, should be understood to the weight ratio of the two azoles of phenylate and ZEN 90160.
One, biological activity determination
Embodiment 1: the two azoles of phenylate and the composite Toxicity Determination to wheat rust of ZEN 90160
Experiment target is designated as wheat leaf rust pathogen (Puccinia recondita), and wheat breed is for raising wheat No. 6, and every basin is selected approximately l0 strain wheat seeding, the 3-4 leaf phase to be grown to is standby, reagent agent and proportioning medicament are mixed with the liquid that presets concentration, and 4 repetitions are established in the processing of spraying, every processing.Get the wheat leaf blade that covers with the leaf rust bacterium after 24h, wash gently with sterile water and get surperficial fresh spore, filter with double gauze, making spore concentration is the suspension of 100,000/ml left and right, spray inoculation (pressure 0.1MPa).After connecing bacterium wheat seeding is under 20 ℃ of conditions, moisturizing one day, then put back to the greenhouse, and when contrasting abundant morbidity, carry out state of an illness investigation by field control effectiveness test criterion grade scale after the week, refer to calculate preventive effect by disease.Obtain EC with return law of the straight line
50
Investigation method and grade scale are as follows:
0 grade: anosis;
1 grade: lesion area accounts for below 5% of one-piece blade area;
3 grades: lesion area accounts for 6% ~ 25% of one-piece blade area;
5 grades: lesion area accounts for 26% ~ 50% of one-piece blade area;
7 grades: lesion area accounts for 51% ~ 75% of one-piece blade area;
9 grades: lesion area accounts for more than 76% of one-piece blade area.
The drug effect computational methods are as follows:
On the basis of chemical control efficient, carry out the data analysis statistics with " DPS data handling system " 3.11 professional versions, obtain regression line, EC
50, correlation coefficient.According to Sun Yunpei (Y-PSun) method (document ... ... each EC that processes that ..) will measure
50Be converted into actual poison exponent (ATI); According to the proportioning of mixture, calculate theoretical poison exponent (TTI), calculate the co-toxicity coefficient (CTC) of mixture by following formula.
The content (%) of toxicity index * A in mixed of theoretical mixed toxicity index (TTI)=A
The content (%) of toxicity index * B of+B in mixed
If co-toxicity coefficient greater than 120, shows the two azoles of phenylate and ZEN 90160 mixture, synergistic effect is arranged; If it is following that co-toxicity coefficient is starkly lower than 100(80), show that its mixture is antagonism; If co-toxicity coefficient is 100～120, show that its mixture is summation action.
The two azoles of phenylate and the composite Toxicity Determination to wheat rust of ZEN 90160 are listed in table 1.
Table 1: the two azoles of phenylate and the composite Toxicity Determination result to wheat rust of ZEN 90160
Embodiment 2: the two azoles of phenylate and the composite Toxicity Determination to wheat powdery mildew of ZEN 90160
Test target wheat powdery mildew (Erysiphe graminis) is cultivated by the long-term live body of this laboratory and is selected susceptible variety (raising wheat No. 6) potted plant, treat that seedling grows to 2 leaves～3 leaf phases, naturally, dries after spraying is processed, the fresh spore of Powdery Mildew that the wheat leaf blade of falling ill was produced in upper 24 hour is evenly shaken off to be inoculated on 2～3 potted plant wheat seedlings of leaf phase that chemicals treatment crosses.Postvaccinal examination material moves to 20 ℃, relative moisture 80% left and right controllable greenhouse glass room is interior cultivates.Note keeping basin soil moistening every day, investigate according to the classification of blank incidence about 7 days.With reference to the pesticide field efficacy medicine test criterion
(1) bactericidal agent for preventing and treating Cereal powdery mildew.
The investigation grade scale:
0 grade: anosis;
1 grade: lesion area accounts for below 5% of one-piece blade area;
3 grades: lesion area accounts for 6% ~ 15% of one-piece blade area;
5 grades: lesion area accounts for 16% ~ 25% of one-piece blade area;
7 grades: lesion area accounts for 26% ~ 50% of one-piece blade area;
9 grades: lesion area accounts for more than 50% of one-piece blade area.
Preventive effect and co-toxicity coefficient computational methods are identical with embodiment 1.
Two azoles of phenylate and ZEN 90160 is composite that the wheat powdery mildew Toxicity Determination be the results are shown in table 2.
Table 2: the two azoles of phenylate and the composite Toxicity Determination result to wheat powdery mildew of ZEN 90160
Can find out from embodiment 1 and 2 Toxicity Determination results (table 1 and 2), when the two azoles of phenylate and ZEN 90160 are mixed in its mass ratio is the scope of 100:1～1:100, they all greater than 120, show that the two azoles of phenylate and ZEN 90160 are mixed wheat powdery mildew and wheat rust are all had synergistic effect to the co-toxicity coefficient CTC of wheat powdery mildew and wheat rust.Wherein mass ratio is that in the scope of 20:1～1:20, synergistic effect is the most obvious.These results show, the two azoles of phenylate and ZEN 90160 are mixed and prevent and treat wheat powdery mildew and rust has reasonability and feasibility.
Two, Preparation Example
In all preparation proportionings, percentage composition is mass percent.
Embodiment 1: the preparation water dispersible granules
Concrete preparation method is as follows: by following formula rate; former medicine and dispersant, wetting agent, binding agent, filler etc. are mixed, obtain pulvis after air-flow crushing, add a certain amount of water to mix; carry out granulation in comminutor, then dry, screening namely gets granular product.
The two azoles of 40% phenylate-ZEN 90160 water dispersible granules preparation:
Take the two former medicines of azoles of 20% phenylate, the 20% former medicine of ZEN 90160,3%NNO(alkylnaphthalene sulfonate formaldehyde condensation products), 2% Nekal BX (nekal), 4%K-12(lauryl sodium sulfate), 5% carboxymethyl (ethyl) cellulose, 3% diatomite, 5% glucose, kaolin add to 100%.Mix, granulate after air-flow crushing.
Embodiment 2: the preparation suspending agent
Concrete preparation method is as follows: by following formula rate, take water as medium, former medicine, dispersant, suspending agent and antifreezing agent etc. joined shears 30min in high-shear emulsion machine, then with obtaining suspending agent after the sand mill sand milling.
The two azoles ZEN 90160 suspending agent preparations of 24% phenylate:
Take the two former medicines of azoles of 20% phenylate, the 4% former medicine of ZEN 90160,3%FS3000(phosphate type anion surfactant), 1%SXC(sulfonic acid type anion surfactant), 0.1% xanthans, 1% aluminium-magnesium silicate, 5% ethylene glycol, 0.15%BIT(1, the 2-benzisothiazole-3-ketone), 0.3% organically-modified silica alkane defoamer, deionized water adds to 100%.Make slurry, carry out sand milling, obtain product.
The two azoles ZEN 90160 suspending agent preparations of 30% phenylate:
Take the two former medicines of azoles of 15% phenylate, the 15% former medicine of ZEN 90160,4%FS3000,1%JFC(fatty alcohol-polyoxyethylene ether), 0.2% xanthans, aluminium-magnesium silicate 1%, 5% ethylene glycol, 0.3% benzoic acid, 0.5% organically-modified silica alkane defoamer, deionized water adds to 100%.Make slurry, carry out sand milling, obtain product.
Embodiment 3: the preparation wetting powder
Concrete preparation method is as follows: by following formula rate, with various auxiliary agents, filler, former medicine mix pulverize by Roughpulverizer after, enter airslide disintegrating mill and fully be pulverized and mixed and make wetting powder.
The two azoles ZEN 90160 wetting powder preparations of 50% phenylate:
Take the two former medicines of azoles of 40% phenylate, the 10% former medicine of ZEN 90160,3%NNO, 2% Nekal BX, 5% white carbon, fine particle calcium carbonate and add to 100%.Mix, obtain product after pulverizing.
The two azoles ZEN 90160 wetting powder preparations of 70% phenylate:
Take the two former medicines of azoles of 50% phenylate, the 20% former medicine of ZEN 90160,5% calcium lignosulfonate, 2% Nekal BX, 1%K-12, kaolin and add to 100%.Mix, obtain product after pulverizing.
Embodiment 4: the preparation microemulsion
The two azoles ZEN 90160 microemulsion preparations of 25% phenylate:
Take the two former medicines of azoles of 5% phenylate, the 20% former medicine of ZEN 90160,5% Nongru-700 #, 5% agriculture breast 500#, 6% agriculture breast 1601#, 15% cyclohexanone, 5%N-methyl pyrrolidone, 5% n-butanol, through dissolve complete and mix, deionized water adds to 100%.After stirring, obtain product.
Embodiment 5: the preparation aqueous emulsion
The two azoles aqueous emulsion preparations of 10% ZEN 90160 phenylate:
Take the 5% former medicine of ZEN 90160, the two former medicines of azoles of 5% phenylate, 3% agriculture breast 2201#, 1.5% Nonyl pheno (EO=10) ether phosphate, 2.5% agriculture breast 600# acid phosphatide, 20% cyclohexanone, 10% solvent naphtha S150, mixed dissolution obtains oil phase.With 5% ethylene glycol, 0.3% xanthans, 0.5% benzoic acid, deionized water adds to 100%, is made into water.Oil phase adds aqueous phase fully to mix, and after high-shear emulsifying, obtains product.
Three, field application test
Application Example 1: control wheat powdery mildew field control effectiveness test
The residential quarter of test medicine, contrast medicament and blank is processed and is adopted random district group to arrange, residential quarter area 20 square meters, 4 repetitions, each spraying control of booting stage and flowering initial stage 1 time.This tests the 7th day and investigation in 15 days of dispenser for the second time, adopts random five point samplings, gets 20 strains at every, upper 3 leaves (having boot leaf to comprise boot leaf) of the every strain of investigation.
The disease scale standard is as follows:
0 grade: without scab;
1 grade: lesion area accounts for below 5% of whole leaf area;
3 grades: lesion area accounts for 6% ~ 15% of whole leaf area;
5 grades: lesion area accounts for 16% ~ 25% of whole leaf area;
7 grades: lesion area accounts for 26% ~ 50% of whole leaf area;
9 grades: lesion area accounts for more than 51% of whole leaf area.
The drug effect computational methods:
According to investigation result, calculate disease index and preventive effect according to following (1), (2) formula.
In formula:
CK0, CK
1Be respectively the forward and backward disease index of blank district's dispenser;
PT
0, PT
1Be respectively the forward and backward disease index of chemicals treatment district's medicine.
Control wheat powdery mildew field control effectiveness test the results are shown in table 3.
Table 3: control wheat powdery mildew field control effectiveness test result
Application Example 2: prevent and treat the wheat rust field control effectiveness test
The residential quarter of test medicine, contrast medicament and blank is processed and is adopted random district group to arrange, residential quarter area 20 square meters, and 4 repetitions, this tests dispenser at the initial stage of a disease 1 time.After medicine, 30 days investigation drug effects, take 5 samplings of every residential quarter diagonal during investigation, and 20 leaves of every some investigation amount to 100 leaves, records the sick level of different disposal according to stage division, calculates disease index and control efficiency.
Grade scale:
0 grade: anosis
1 grade: lesion area accounts for below 5% of one-piece blade area;
3 grades: lesion area accounts for 6%～25% of one-piece blade area:
5 grades: lesion area accounts for the 26%-50% of one-piece blade area;
7 grades: lesion area accounts for 51%.75% of one-piece blade area;
9 grades: lesion area accounts for more than 76% of one-piece blade area.
According to investigation result, calculate disease index and anti-efficient according to following formula (1), (2).
In formula:
CK
0, CK
1Be respectively the forward and backward disease index of blank district's dispenser;
PT
0, PT
1Be respectively the forward and backward disease index of chemicals treatment district's medicine.
Prevent and treat the wheat rust field control effectiveness test and the results are shown in table 4.
Table 4: prevent and treat wheat rust field control effectiveness test result
Above-mentioned indoor biometrics and field control effectiveness test result clearly illustrate that, bactericidal composition of the present invention has following beneficial effect:
(1) compare with single dose, this bactericidal composition has significant synergistic effect to disease, has improved bactericidal effect;
(2) reduce the medication number of times, lower drug cost, environmental contamination reduction and residue of pesticide;
(3) composition is comprised of the active ingredient of different mechanism of action, and action site increases, and is conducive to overcome and delays the drug-fast generation of germ.All without obviously harmful effect, leaf look, growing way etc. are all normal to trial crops for the present composition, and safety is good, meets the security requirement of pesticidal preparations.Bactericidal composition of the present invention has good control efficiency to wheat powdery mildew and rust.
Claims (8)
1. bactericidal composition that contains the two azoles of phenylate and ZEN 90160, the active ingredient that it is characterized in that this bactericidal composition is component A and B:
A is the two azoles of phenylate with following structural formula:
B is ZEN 90160;
Wherein the weight ratio of component A and B component is 1:100～100:1.
2. bactericidal composition according to claim 1 is characterized in that in this bactericidal composition, the weight ratio of component A and B component is 1:50～50:1.
3. bactericidal composition according to claim 1 is characterized in that in this bactericidal composition, the weight ratio of component A and B component is 1:10～10:1.
4. bactericide is characterized in that this bactericide contains that in the claim 1-3 of 0.1～90 % by weight, the described bactericidal composition of any one claim and surplus are acceptable carrier and auxiliary agent on agricultural chemicals.
5. according to claim 4 bactericide is characterized in that this bactericide contains the described bactericidal composition of any one claim in the claim 1-3 of 3～80 % by weight.
6. according to claim 4 bactericide is characterized in that this bactericide contains the described bactericidal composition of any one claim in the claim 1-3 of 15～70 % by weight.
7. the described bactericide of any one claim according to claim 4-6, is characterized in that this bactericide is mixed with suspending agent, aqueous emulsion, microemulsion, wetting powder or water dispersible granules.
8. the purposes of the described bactericidal composition of any one claim in control wheat powdery mildew and rust according to claim 1-3.
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| US20150307459A1 (en) | 2012-11-27 | 2015-10-29 | Basf Se | Substituted 2-[phenoxy-phenyl]-1-[1,2,4]triazol-1-yl-ethanol Compounds and Their Use as Fungicides |
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Address after: 311106 No. 172, Zhangjiadun Road, Tangqi Town, Linping District, Hangzhou, Zhejiang Patentee after: Zhejiang Yulong Pharmaceutical Co.,Ltd. Address before: No. 172, zhangjiadun Road, Tangqi Town, Yuhang District, Hangzhou City, Zhejiang Province, 311106 Patentee before: Hangzhou Udragon Chemical Co.,Ltd. |
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