CN102696599A - Concentrated compound peroxyacetic acid and quaternary ammonium salt disinfection solution - Google Patents
Concentrated compound peroxyacetic acid and quaternary ammonium salt disinfection solution Download PDFInfo
- Publication number
- CN102696599A CN102696599A CN2012101817010A CN201210181701A CN102696599A CN 102696599 A CN102696599 A CN 102696599A CN 2012101817010 A CN2012101817010 A CN 2012101817010A CN 201210181701 A CN201210181701 A CN 201210181701A CN 102696599 A CN102696599 A CN 102696599A
- Authority
- CN
- China
- Prior art keywords
- quaternary ammonium
- ammonium salt
- acid
- thimerosal
- concentrated compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention relates to concentrated compound peroxyacetic acid and quaternary ammonium salt disinfection solution, which comprises the following components in percent by weight: 5-10 of peroxyacetic acid, 5-20 of quaternary ammonium salt, 1-5 of ethanol, 0.5-2 of ethylenediamine tetraacetic acid disodium, 0.5-1 of benzotriazole, 0.1-0.5 of inorganic acid and balance of water. The preparation method of the concentrated compound peroxyacetic acid and quaternary ammonium salt disinfection solution comprises the steps of: adding the ethylenediamine tetraacetic acid disodium and the benzotriazole into the water according to the content and agitating for dissolution; adding the ethanol and evenly agitating and mixing; and adding the quaternary ammonium salt and agitating for dissolution; adding the peroxyacetic acid, then adding the inorganic acid, agitating for dissolution and evenly mixing to obtain the concentrated compound peroxyacetic acid and quaternary ammonium salt disinfection solution. The concentrated compound peroxyacetic acid and quaternary ammonium salt disinfection solution has the advantages of stable product performance and good disinfection effect, and can be widely used for environmental disinfection and sterilization of public places.
Description
Technical field
The present invention relates to thimerosal, relate in particular to a kind of compound quaternary ammonium salt thimerosal.
Background technology
Peracetic acid is a kind of strong oxidizer, can kill bacteria, fungi, virus and gemma, can be widely used in the sterilization of utensil, air and environment.The advantage that Peracetic acid is the most outstanding is finally to be decomposed into acetic acid, water and oxygen after it uses, and can not stay any harmful substance, and environment is not formed pollution, is a kind of environment-friendly type disinfectant.Yet Peracetic acid character is unstable, also brings very big inconvenience to its application.
Quaternary ammonium salt is a kind of poor efficiency bactericide, and its mechanism of action is through cation electrostatic force, hydrogen bond force, is adsorbed onto on the electronegative bacterial body, and generating chamber's inhibition effect suppresses bacterial respiratory; The alkyl chain of quaternary ammonium salt can change the permeability of microbial film simultaneously, causes the dissolving and the death of cell.The advantage of quaternary ammonium salt is safety low-poison, as cationic surfactant, has cleaning action.The shortcoming of quaternary ammonium salt mainly is if long-term use separately is easy to generate pesticide resistance.
Summary of the invention
The present invention is intended to overcome poor stability, the weak shortcoming of quaternary ammonium salt bactericide power of low concentration Peracetic acid, and a kind of concentrated compound peracetic acid quaternary ammonium salt thimerosal is provided.The preparation technology of the compound peracetic acid quaternary ammonium salt thimerosal that the present invention concentrates is simple, and product property is stable, and bactericidal action is strong.
A kind of concentrated compound peracetic acid quaternary ammonium salt thimerosal is characterized in that it comprises each component of following each percetage by weight:
Peracetic acid, 5-10;
Quaternary ammonium salt, 5-20;
Ethanol, 1-5;
Disodium ethylene diamine tetraacetate, 0.5-2;
Benzotriazole, 0.5-1;
Inorganic acid, 0.1-0.5;
Water, surplus.
Described thimerosal is characterized in that, said quaternary ammonium salt is C
12-C
16Zephiran or C
8-C
10Two alkyl-dimethyl ammonium chlorides.
Described thimerosal is characterized in that, said quaternary ammonium salt can be C
12-C
16The zephiran list is used or C
8-C
10Two alkyl-dimethyl ammonium chloride lists are used or C
12-C
16Zephiran and C
8-C
10Two alkyl-dimethyl ammonium chlorides share.
Described thimerosal is characterized in that, said inorganic acid is phosphoric acid or boric acid.
The preparation method of described thimerosal is: by said content and component, disodium ethylene diamine tetraacetate and benzotriazole are added to the water stirring and dissolving; Add ethanol, mix; Add quaternary ammonium salt, stirring and dissolving; Add Peracetic acid, add inorganic acid again, stirring and dissolving mixes, and promptly gets described concentrated compound peracetic acid quaternary ammonium salt thimerosal.
Described thimerosal is characterized in that, said thimerosal is 100 times of uses of dilute with water.
Compound peracetic acid quaternary ammonium salt thimerosal of the present invention utilizes the sterilizing power of Peracetic acid and the close microbial performance of quaternary ammonium salt, and The combined is used, the performance synergistic function.Ethanol is a kind of micromolecular compound, has short osmosis, can help Peracetic acid to penetrate in the microbial body.The present invention adopts disodium ethylene diamine tetraacetate as the complexing of metal ion agent, gets rid of the decomposition facilitation of metal ion to Peracetic acid.The present invention adopts benzotriazole as corrosion inhibiter, suppresses the corrosivity of Peracetic acid.The present invention simultaneously adopts the inorganic acid of irreducibility to come adjustment of acidity pH value, helps to improve the stability of Peracetic acid.
Embodiment
Below, in conjunction with specific embodiment, further specify the present invention:
A kind of concentrated compound peracetic acid quaternary ammonium salt thimerosal is characterized in that it comprises each component of following each percetage by weight:
Peracetic acid, 5-10;
Quaternary ammonium salt, 5-20;
Ethanol, 1-5;
Disodium ethylene diamine tetraacetate, 0.5-2;
Benzotriazole, 0.5-1;
Inorganic acid, 0.1-0.5;
Water, surplus.
Described thimerosal is characterized in that, said quaternary ammonium salt is C
12-C
16Zephiran or C
8-C
10Two alkyl-dimethyl ammonium chlorides.
Described thimerosal is characterized in that, said quaternary ammonium salt can be C
12-C
16The zephiran list is used or C
8-C
10Two alkyl-dimethyl ammonium chloride lists are used or C
12-C
16Zephiran and C
8-C
10Two alkyl-dimethyl ammonium chlorides share.
Described thimerosal is characterized in that, said inorganic acid is phosphoric acid or boric acid.
The preparation method of described thimerosal is: by said content and component, disodium ethylene diamine tetraacetate and benzotriazole are added to the water stirring and dissolving; Add ethanol, mix; Add quaternary ammonium salt, stirring and dissolving; Add Peracetic acid, add inorganic acid again, stirring and dissolving mixes, and promptly gets described concentrated compound peracetic acid quaternary ammonium salt thimerosal.
Described thimerosal is characterized in that, said thimerosal is 100 times of uses of dilute with water.
Embodiment 1
Disodium ethylene diamine tetraacetate 10 grams and benzotriazole 5 grams are joined in the 702 gram water stirring and dissolving; Add ethanol 30 grams, mix; Add dodecyl benzyl dimethyl ammonium chloride 200 grams, stirring and dissolving; Add Peracetic acid 50 grams, add phosphoric acid 3 grams again, stirring and dissolving mixes, and promptly gets described concentrated compound peracetic acid quaternary ammonium salt thimerosal.
Embodiment 2
Disodium ethylene diamine tetraacetate 5 grams and benzotriazole 10 grams are joined in the 754 gram water stirring and dissolving; Add ethanol 50 grams, mix; Add octyl-decyl dimethyl benzyl ammonium chloride 100 grams, stirring and dissolving; Add Peracetic acid 80 grams, add phosphoric acid 1 gram again, stirring and dissolving mixes, and promptly gets described concentrated compound peracetic acid quaternary ammonium salt thimerosal.
Embodiment 3
Disodium ethylene diamine tetraacetate 20 grams and benzotriazole 7 grams are joined in the 808 gram water stirring and dissolving; Add ethanol 10 grams, mix; Add dodecyl benzyl dimethyl ammonium chloride 30 grams and octyl-decyl dimethyl benzyl ammonium chloride 20 grams, stirring and dissolving; Add Peracetic acid 100 grams, add phosphoric acid 5 grams again, stirring and dissolving mixes, and promptly gets described concentrated compound peracetic acid quaternary ammonium salt thimerosal.
Get above-mentioned each embodiment; 100 times of dilute with waters adopt carrier quantitative germicidal test, under 19-21 ℃ of condition; It is equal that effect 1min on average kills logarithm value to staphylococcus aureus>5.0; It is equal that effect 1min on average kills logarithm value to Escherichia coli>5.0, it is equal that effect 1min on average kills logarithm value to pseudomonas aeruginosa>5.0, it is equal that effect 1min on average kills logarithm value to Candida albicans>4.0.
Get above-mentioned each embodiment, adopt 54 ℃ of accelerated stability tests of depositing 14 days, active o content rate of descent equal < 10%.
Like the compound peracetic acid quaternary ammonium salt thimerosal that concentrates that above-mentioned embodiment makes, product property is stable, and bactericidal effect is good, can be widely used in the environment sterilizing of each public place.
Claims (3)
1. concentrated compound peracetic acid quaternary ammonium salt thimerosal is characterized in that it comprises each component of following percetage by weight:
Peracetic acid, 5-10;
Quaternary ammonium salt, 5-20;
Ethanol, 1-5;
Disodium ethylene diamine tetraacetate, 0.5-2;
Benzotriazole, 0.5-1;
Phosphoric acid or boric acid, 0.1-0.5;
Water, surplus;
Said quaternary ammonium salt is C
12-C
16Zephiran or C
8-C
10In two alkyl-dimethyl ammonium chlorides one or both.
2. the preparation method of thimerosal according to claim 1 is: by said content and component, disodium ethylene diamine tetraacetate and benzotriazole are added to the water stirring and dissolving; Add ethanol, mix; Add quaternary ammonium salt, stirring and dissolving; Add Peracetic acid, add inorganic acid again, stirring and dissolving mixes, and promptly gets described concentrated compound peracetic acid quaternary ammonium salt thimerosal.
3. thimerosal according to claim 1 and 2 is characterized in that, said thimerosal is 100 times of uses of dilute with water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101817010A CN102696599A (en) | 2012-06-05 | 2012-06-05 | Concentrated compound peroxyacetic acid and quaternary ammonium salt disinfection solution |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101817010A CN102696599A (en) | 2012-06-05 | 2012-06-05 | Concentrated compound peroxyacetic acid and quaternary ammonium salt disinfection solution |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102696599A true CN102696599A (en) | 2012-10-03 |
Family
ID=46889903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012101817010A Pending CN102696599A (en) | 2012-06-05 | 2012-06-05 | Concentrated compound peroxyacetic acid and quaternary ammonium salt disinfection solution |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102696599A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103719142A (en) * | 2012-10-10 | 2014-04-16 | 俞致健 | Disinfectant as well as preparation method and application thereof |
| WO2018075089A1 (en) * | 2016-10-21 | 2018-04-26 | Ecolab Usa Inc. | REDUCED INHALATION HAZARD OF QUATERNARY AMMONIUM COMPOUNDS-pH DRIVEN PHYSIOLOGICAL RESPONSE |
| US10426162B2 (en) | 2016-08-11 | 2019-10-01 | Ecolab Usa Inc. | Interaction between antimicrobial quaternary compounds and anionic surfactants |
| CN111513067A (en) * | 2020-04-29 | 2020-08-11 | 江苏斯微特医药科技有限公司 | Compound alcohol-oxygen-sugar disinfectant |
| CN113181395A (en) * | 2021-04-30 | 2021-07-30 | 新疆维吾尔自治区人民医院 | Clinical laboratory covering type sterilization device and control method thereof |
| US11406103B2 (en) | 2016-03-01 | 2022-08-09 | Ecolab Usa Inc. | Sanitizing rinse based on quat-anionic surfactant synergy |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090202656A1 (en) * | 2008-02-08 | 2009-08-13 | Gimvang Bo H | Antimicrobial coating |
| CN101507430A (en) * | 2009-03-31 | 2009-08-19 | 中国检验检疫科学研究院 | Freezeproof foam disinfectant and preparation method thereof |
| CN101810171A (en) * | 2010-04-20 | 2010-08-25 | 云南大学 | Novel environmentally-friendly corrosion-resistance peracetic acid disinfectant |
| CN102037959A (en) * | 2010-12-29 | 2011-05-04 | 广东环凯微生物科技有限公司 | Method for preparing stable peracetic acid disinfectant |
-
2012
- 2012-06-05 CN CN2012101817010A patent/CN102696599A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090202656A1 (en) * | 2008-02-08 | 2009-08-13 | Gimvang Bo H | Antimicrobial coating |
| CN101507430A (en) * | 2009-03-31 | 2009-08-19 | 中国检验检疫科学研究院 | Freezeproof foam disinfectant and preparation method thereof |
| CN101810171A (en) * | 2010-04-20 | 2010-08-25 | 云南大学 | Novel environmentally-friendly corrosion-resistance peracetic acid disinfectant |
| CN102037959A (en) * | 2010-12-29 | 2011-05-04 | 广东环凯微生物科技有限公司 | Method for preparing stable peracetic acid disinfectant |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103719142A (en) * | 2012-10-10 | 2014-04-16 | 俞致健 | Disinfectant as well as preparation method and application thereof |
| CN103719142B (en) * | 2012-10-10 | 2015-09-16 | 俞致健 | A kind of disinfectant and preparation method thereof and application |
| US11406103B2 (en) | 2016-03-01 | 2022-08-09 | Ecolab Usa Inc. | Sanitizing rinse based on quat-anionic surfactant synergy |
| US10426162B2 (en) | 2016-08-11 | 2019-10-01 | Ecolab Usa Inc. | Interaction between antimicrobial quaternary compounds and anionic surfactants |
| US11044907B2 (en) | 2016-08-11 | 2021-06-29 | Ecolab Usa Inc. | Interaction between antimicrobial quaternary compounds and anionic surfactants |
| US11839209B2 (en) | 2016-08-11 | 2023-12-12 | Ecolab Usa Inc. | Interaction between antimicrobial quaternary compounds and anionic surfactants |
| WO2018075089A1 (en) * | 2016-10-21 | 2018-04-26 | Ecolab Usa Inc. | REDUCED INHALATION HAZARD OF QUATERNARY AMMONIUM COMPOUNDS-pH DRIVEN PHYSIOLOGICAL RESPONSE |
| CN111513067A (en) * | 2020-04-29 | 2020-08-11 | 江苏斯微特医药科技有限公司 | Compound alcohol-oxygen-sugar disinfectant |
| CN113181395A (en) * | 2021-04-30 | 2021-07-30 | 新疆维吾尔自治区人民医院 | Clinical laboratory covering type sterilization device and control method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102696599A (en) | Concentrated compound peroxyacetic acid and quaternary ammonium salt disinfection solution | |
| CN101933521B (en) | Preparation and application thereof of sterilization composition | |
| CN101810171B (en) | Novel environmentally-friendly corrosion-resistance peracetic acid disinfectant | |
| US10226048B2 (en) | Disinfecting detergent | |
| CN109777639B (en) | Preparation for disinfecting and cleaning hard surface of air conditioner and general objects and preparation method thereof | |
| US8940792B2 (en) | Antimicrobial composition and methods for using same | |
| CN103843817A (en) | Hydrogen peroxide and peracetic acid mixed disinfectant and preparation method thereof | |
| CN102696674A (en) | Low-concentration hydrogen peroxide disinfectant and preparation method thereof | |
| CN1788564A (en) | Sterilization disinfectant and application thereof | |
| CN111700822A (en) | Skin disinfectant and preparation method thereof | |
| CN101785460B (en) | O-phthalaldehyde disinfectant and preparation method thereof | |
| CN108477209A (en) | A kind of thimerosal and preparation method thereof | |
| JPH03501581A (en) | How to control biological contamination in recirculating water supply systems | |
| CN112022732A (en) | Hand-washing-free disinfectant and preparation method thereof | |
| CN102326534A (en) | Method for preparing chlorine-containing disinfectant fluid | |
| CN101785477A (en) | Polyoxyethylene nonyl phenyl ether iodine complex disinfecting solution and preparation method thereof | |
| CN104336014A (en) | Composite double-long-chain hyamine disinfectant | |
| CN104488862A (en) | Anion-cation surface-active agent compounded disinfectant technology | |
| US8778370B2 (en) | Method and composition for inhibiting growth of microorganisms in industrial process waters in the presence of anionic anti-fouling additives | |
| CN107079907A (en) | A kind of cationic anionic surfactant combination disinfectant technology | |
| CN101606534B (en) | Bromine-containing disinfecting agent | |
| CN107079925A (en) | Deodorization and sterilization hydro-peening liquid clean may just as well excellent and available for gas-solid liquid environment | |
| JP7073593B1 (en) | Antibacterial, antifungal, antiviral disinfectant composition | |
| CN103355315B (en) | Composition acted on Biocidal and application thereof | |
| WO2014153293A1 (en) | Methods and apparatuses related to treatment in milking facilities |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20121003 |