CN102641357A - 一种治疗高血压的药物及其制备方法 - Google Patents
一种治疗高血压的药物及其制备方法 Download PDFInfo
- Publication number
- CN102641357A CN102641357A CN2012101367822A CN201210136782A CN102641357A CN 102641357 A CN102641357 A CN 102641357A CN 2012101367822 A CN2012101367822 A CN 2012101367822A CN 201210136782 A CN201210136782 A CN 201210136782A CN 102641357 A CN102641357 A CN 102641357A
- Authority
- CN
- China
- Prior art keywords
- add
- filter
- ethanol
- pharmaceutical composition
- hours
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 33
- 206010020772 Hypertension Diseases 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 94
- 241000218628 Ginkgo Species 0.000 claims abstract description 20
- 235000011201 Ginkgo Nutrition 0.000 claims abstract description 20
- 235000008100 Ginkgo biloba Nutrition 0.000 claims abstract description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000002775 capsule Substances 0.000 claims abstract description 6
- 239000008187 granular material Substances 0.000 claims abstract description 6
- 239000006187 pill Substances 0.000 claims abstract description 5
- 239000003826 tablet Substances 0.000 claims abstract description 3
- 239000000706 filtrate Substances 0.000 claims description 30
- 238000001035 drying Methods 0.000 claims description 21
- 238000004064 recycling Methods 0.000 claims description 20
- 241000628997 Flos Species 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 16
- 239000008194 pharmaceutical composition Substances 0.000 claims description 14
- 241000345998 Calamus manan Species 0.000 claims description 10
- 230000006837 decompression Effects 0.000 claims description 10
- 239000000284 extract Substances 0.000 claims description 10
- 235000012950 rattan cane Nutrition 0.000 claims description 10
- 238000010992 reflux Methods 0.000 claims description 10
- 229940079593 drug Drugs 0.000 claims description 9
- 239000002671 adjuvant Substances 0.000 claims description 7
- 230000008569 process Effects 0.000 claims description 7
- 239000002552 dosage form Substances 0.000 claims description 6
- 230000001631 hypertensive effect Effects 0.000 claims description 5
- 239000000890 drug combination Substances 0.000 claims description 3
- 230000036772 blood pressure Effects 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 8
- 239000000463 material Substances 0.000 abstract description 5
- 208000007530 Essential hypertension Diseases 0.000 abstract description 2
- 239000002131 composite material Substances 0.000 abstract 4
- 239000004480 active ingredient Substances 0.000 abstract 2
- 230000001914 calming effect Effects 0.000 abstract 2
- 241000157373 Uncaria rhynchophylla Species 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 241000700159 Rattus Species 0.000 description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
- 230000002792 vascular Effects 0.000 description 9
- 210000004185 liver Anatomy 0.000 description 8
- 201000010099 disease Diseases 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- 210000003734 kidney Anatomy 0.000 description 5
- PQSUYGKTWSAVDQ-ZVIOFETBSA-N Aldosterone Chemical compound C([C@@]1([C@@H](C(=O)CO)CC[C@H]1[C@@H]1CC2)C=O)[C@H](O)[C@@H]1[C@]1(C)C2=CC(=O)CC1 PQSUYGKTWSAVDQ-ZVIOFETBSA-N 0.000 description 4
- PQSUYGKTWSAVDQ-UHFFFAOYSA-N Aldosterone Natural products C1CC2C3CCC(C(=O)CO)C3(C=O)CC(O)C2C2(C)C1=CC(=O)CC2 PQSUYGKTWSAVDQ-UHFFFAOYSA-N 0.000 description 4
- 102000002045 Endothelin Human genes 0.000 description 4
- 108050009340 Endothelin Proteins 0.000 description 4
- 229960002478 aldosterone Drugs 0.000 description 4
- FAKRSMQSSFJEIM-RQJHMYQMSA-N captopril Chemical compound SC[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O FAKRSMQSSFJEIM-RQJHMYQMSA-N 0.000 description 4
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 description 4
- 206010019233 Headaches Diseases 0.000 description 3
- CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 description 3
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- 208000002173 dizziness Diseases 0.000 description 3
- 231100000869 headache Toxicity 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 3
- 239000008108 microcrystalline cellulose Substances 0.000 description 3
- 229940016286 microcrystalline cellulose Drugs 0.000 description 3
- 208000037920 primary disease Diseases 0.000 description 3
- 230000000630 rising effect Effects 0.000 description 3
- 229910002027 silica gel Inorganic materials 0.000 description 3
- 239000000741 silica gel Substances 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 230000035488 systolic blood pressure Effects 0.000 description 3
- 102000005862 Angiotensin II Human genes 0.000 description 2
- 101800000733 Angiotensin-2 Proteins 0.000 description 2
- 229920001353 Dextrin Polymers 0.000 description 2
- 239000004375 Dextrin Substances 0.000 description 2
- PUQSUZTXKPLAPR-UJPOAAIJSA-N Gastrodin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(CO)C=C1 PUQSUZTXKPLAPR-UJPOAAIJSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- 229950006323 angiotensin ii Drugs 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 235000019425 dextrin Nutrition 0.000 description 2
- 230000035487 diastolic blood pressure Effects 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 210000002254 renal artery Anatomy 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 229910052709 silver Inorganic materials 0.000 description 2
- 239000004332 silver Substances 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 108010072661 Angiotensin Amide Proteins 0.000 description 1
- 108010011485 Aspartame Proteins 0.000 description 1
- 229940127291 Calcium channel antagonist Drugs 0.000 description 1
- 206010009346 Clonus Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- QGMRQYFBGABWDR-UHFFFAOYSA-M Pentobarbital sodium Chemical compound [Na+].CCCC(C)C1(CC)C(=O)NC(=O)[N-]C1=O QGMRQYFBGABWDR-UHFFFAOYSA-M 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 241001601725 Sthenias Species 0.000 description 1
- 208000009205 Tinnitus Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000003276 anti-hypertensive effect Effects 0.000 description 1
- 210000000709 aorta Anatomy 0.000 description 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
- 229960003438 aspartame Drugs 0.000 description 1
- 235000010357 aspartame Nutrition 0.000 description 1
- 239000000605 aspartame Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000002876 beta blocker Substances 0.000 description 1
- 229940097320 beta blocking agent Drugs 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000010241 blood sampling Methods 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000000480 calcium channel blocker Substances 0.000 description 1
- 229960000830 captopril Drugs 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000008753 endothelial function Effects 0.000 description 1
- 210000003038 endothelium Anatomy 0.000 description 1
- 239000002532 enzyme inhibitor Substances 0.000 description 1
- 229940125532 enzyme inhibitor Drugs 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000001077 hypotensive effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 229960002275 pentobarbital sodium Drugs 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- RZWIIPASKMUIAC-VQTJNVASSA-N thromboxane Chemical compound CCCCCCCC[C@H]1OCCC[C@@H]1CCCCCCC RZWIIPASKMUIAC-VQTJNVASSA-N 0.000 description 1
- 239000008853 tianma gouteng Substances 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000003845 vascular endothelial function Effects 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims (6)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2012101367822A CN102641357B (zh) | 2012-05-07 | 2012-05-07 | 一种治疗高血压的药物及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2012101367822A CN102641357B (zh) | 2012-05-07 | 2012-05-07 | 一种治疗高血压的药物及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102641357A true CN102641357A (zh) | 2012-08-22 |
CN102641357B CN102641357B (zh) | 2013-08-21 |
Family
ID=46654601
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2012101367822A Active CN102641357B (zh) | 2012-05-07 | 2012-05-07 | 一种治疗高血压的药物及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN102641357B (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104013875A (zh) * | 2014-05-16 | 2014-09-03 | 王康琪 | 一种降血压黑膏药及其制备方法 |
CN104906426A (zh) * | 2015-06-26 | 2015-09-16 | 苗怡文 | 一种治疗原发性高血压的中药制剂及其制备方法 |
CN113546116A (zh) * | 2021-07-19 | 2021-10-26 | 河南省中医药研究院 | 一种具有降压功效的中药提取物的制备方法 |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0872243A1 (en) * | 1996-03-12 | 1998-10-21 | Teh-Shan Chang | Herb composition, herbal paste and herbal plaster made from the same |
JPH11209274A (ja) * | 1998-01-22 | 1999-08-03 | Bae O-Sung | 疾病治療用喫煙物 |
CN1555868A (zh) * | 2004-01-09 | 2004-12-22 | 张桂英 | 一种降血压中药及其制备方法 |
CN1686458A (zh) * | 2005-05-13 | 2005-10-26 | 成都九芝堂金鼎药业有限公司 | 一种中药组合物、其制备方法及其用途 |
JP2006045168A (ja) * | 2004-08-09 | 2006-02-16 | Kao Corp | S100a8発現調節剤 |
KR20080045770A (ko) * | 2006-11-21 | 2008-05-26 | 김우원 | 노인성질환치료예방용 한방떡의 제조방법 및 그 제조된한방떡 |
CN102258714A (zh) * | 2011-07-07 | 2011-11-30 | 周建国 | 一种用于治疗高血压的中药胶囊 |
CN102423354A (zh) * | 2011-11-01 | 2012-04-25 | 文登市口腔医院米山路口腔诊所 | 一种治疗高血压病的中药 |
-
2012
- 2012-05-07 CN CN2012101367822A patent/CN102641357B/zh active Active
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0872243A1 (en) * | 1996-03-12 | 1998-10-21 | Teh-Shan Chang | Herb composition, herbal paste and herbal plaster made from the same |
JPH11209274A (ja) * | 1998-01-22 | 1999-08-03 | Bae O-Sung | 疾病治療用喫煙物 |
CN1555868A (zh) * | 2004-01-09 | 2004-12-22 | 张桂英 | 一种降血压中药及其制备方法 |
JP2006045168A (ja) * | 2004-08-09 | 2006-02-16 | Kao Corp | S100a8発現調節剤 |
CN1686458A (zh) * | 2005-05-13 | 2005-10-26 | 成都九芝堂金鼎药业有限公司 | 一种中药组合物、其制备方法及其用途 |
KR20080045770A (ko) * | 2006-11-21 | 2008-05-26 | 김우원 | 노인성질환치료예방용 한방떡의 제조방법 및 그 제조된한방떡 |
CN102258714A (zh) * | 2011-07-07 | 2011-11-30 | 周建国 | 一种用于治疗高血压的中药胶囊 |
CN102423354A (zh) * | 2011-11-01 | 2012-04-25 | 文登市口腔医院米山路口腔诊所 | 一种治疗高血压病的中药 |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104013875A (zh) * | 2014-05-16 | 2014-09-03 | 王康琪 | 一种降血压黑膏药及其制备方法 |
CN104013875B (zh) * | 2014-05-16 | 2018-07-06 | 王康琪 | 一种降血压黑膏药及其制备方法 |
CN104906426A (zh) * | 2015-06-26 | 2015-09-16 | 苗怡文 | 一种治疗原发性高血压的中药制剂及其制备方法 |
CN113546116A (zh) * | 2021-07-19 | 2021-10-26 | 河南省中医药研究院 | 一种具有降压功效的中药提取物的制备方法 |
CN113546116B (zh) * | 2021-07-19 | 2022-08-30 | 河南省中医药研究院 | 一种具有降压功效的中药提取物的制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN102641357B (zh) | 2013-08-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN100366280C (zh) | 一种治疗高血压的药物组合物及其制备方法和用途 | |
CN102895432A (zh) | 开心散新剂型处方工艺及其制备方法 | |
CN101810806B (zh) | 一种用于治疗高泌乳素血症的药物及其制备方法 | |
CN102641357B (zh) | 一种治疗高血压的药物及其制备方法 | |
CN1943757B (zh) | 一种治疗偏头痛的中药组合物及其制备方法 | |
CN107648479B (zh) | 一种用于治疗高血压的中药组方及其制品 | |
CN102657736B (zh) | 一种治疗类风湿性关节炎的药物组合物及其制备方法 | |
CN101104056B (zh) | 一种治疗肺痈症的药物及其制备方法 | |
CN1943756B (zh) | 一种治疗高血压的中药组合物及其制备方法 | |
CN102058786B (zh) | 一种治疗高血压的中药组合物及其制备方法 | |
CN1943755B (zh) | 一种治疗高血压的中药组合物及其制备方法 | |
CN104337909B (zh) | 一种含九香虫的治疗痛风的中药组合物 | |
CN105833043A (zh) | 一种中药组合物在制备治疗原发性高血压药物中的用途 | |
CN105853766A (zh) | 一种中药制剂在制备治疗原发性高血压药物中的用途 | |
CN106563076B (zh) | 一种治疗胃病的药物及其制作方法 | |
CN104435079A (zh) | 一种治疗痛风的中药组合物 | |
CN104337898B (zh) | 一种含郁李仁的治疗痛风的中药组合物 | |
CN103142923A (zh) | 一种治疗冠心病的复方蒙药制剂 | |
CN107913315A (zh) | 一种治疗难治性高血压的中药组合物及其制备方法 | |
CN102988636B (zh) | 一种含有硝苯地平和中药提取物的药物组合物 | |
CN102895433A (zh) | 读书丸新剂型处方工艺及其制备方法 | |
CN102886017A (zh) | 一种治疗***的中药 | |
CN105169090B (zh) | 一种天麻杜仲复方药物组合物 | |
CN105362703A (zh) | 一种治疗原发性高血压的中药组合物及其制备方法 | |
CN102552399B (zh) | 一种清热平肝的中药组合物及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: CHEN XIUMEI Effective date: 20130717 |
|
C41 | Transfer of patent application or patent right or utility model | ||
C53 | Correction of patent of invention or patent application | ||
CB03 | Change of inventor or designer information |
Inventor after: Liu Jianwei Inventor after: Chen Xiumei Inventor after: Sun Zhiqiang Inventor before: Sun Zhiqiang |
|
COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: SUN ZHIQIANG TO: LIU JIANWEI CHEN XIUMEI SUN ZHIQIANG |
|
TA01 | Transfer of patent application right |
Effective date of registration: 20130717 Address after: 250031, unit 5, building 1, central garden, 17 West Industrial and commercial road, Tianqiao District, Shandong, Ji'nan, 402 Applicant after: Sun Zhiqiang Applicant after: Chen Xiumei Address before: 250031, unit 5, building 1, central garden, 17 West Industrial and commercial road, Tianqiao District, Shandong, Ji'nan, 402 Applicant before: Sun Zhiqiang |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Free format text: FORMER OWNER: CHEN XIUMEI Effective date: 20141103 Owner name: SANLI PHARMACEUTICAL CO., LTD., GUIZHOU Free format text: FORMER OWNER: SUN ZHIQIANG Effective date: 20141103 |
|
C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 250031 JINAN, SHANDONG PROVINCE TO: 550003 GUIYANG, GUIZHOU PROVINCE |
|
TR01 | Transfer of patent right |
Effective date of registration: 20141103 Address after: 550003 No. 104 Fu Lu, Yunyan District, Guizhou, Guiyang Patentee after: Guizhou Sanli Pharmacy Ltd. Address before: 250031, unit 5, building 1, central garden, 17 West Industrial and commercial road, Tianqiao District, Shandong, Ji'nan, 402 Patentee before: Sun Zhiqiang Patentee before: Chen Xiumei |
|
C56 | Change in the name or address of the patentee |
Owner name: GUIZHOU SANLI PHARMACEUTICAL CO., LTD. Free format text: FORMER NAME: SANLI PHARMACEUTICAL CO., LTD., GUIZHOU |
|
CP01 | Change in the name or title of a patent holder |
Address after: 550003 No. 104 Fu Lu, Yunyan District, Guizhou, Guiyang Patentee after: Guizhou three power Pharmacy stock Co., Ltd Address before: 550003 No. 104 Fu Lu, Yunyan District, Guizhou, Guiyang Patentee before: Guizhou Sanli Pharmacy Ltd. |
|
C56 | Change in the name or address of the patentee | ||
CP02 | Change in the address of a patent holder |
Address after: Xia Yun Industrial Park Guizhou city Anshun province Pingba District 561100 Patentee after: Guizhou three power Pharmacy stock Co., Ltd Address before: 550003 No. 104 Fu Lu, Yunyan District, Guizhou, Guiyang Patentee before: Guizhou three power Pharmacy stock Co., Ltd |