CN102631523B - Drug with effects of clearing damp and relieving detoxify and killing parasites and relieving itching, as well as preparation method of drug - Google Patents
Drug with effects of clearing damp and relieving detoxify and killing parasites and relieving itching, as well as preparation method of drug Download PDFInfo
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- CN102631523B CN102631523B CN 201210142860 CN201210142860A CN102631523B CN 102631523 B CN102631523 B CN 102631523B CN 201210142860 CN201210142860 CN 201210142860 CN 201210142860 A CN201210142860 A CN 201210142860A CN 102631523 B CN102631523 B CN 102631523B
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- killing parasites
- relieving itching
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- 239000003814 drug Substances 0.000 title claims abstract description 29
- 208000003251 Pruritus Diseases 0.000 title claims abstract description 17
- 229940079593 drug Drugs 0.000 title claims abstract description 15
- 230000007803 itching Effects 0.000 title claims abstract description 11
- 244000045947 parasite Species 0.000 title claims abstract description 11
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 230000000694 effects Effects 0.000 title abstract description 3
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 claims abstract description 6
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 5
- 102000002322 Egg Proteins Human genes 0.000 claims description 9
- 108010000912 Egg Proteins Proteins 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 8
- 241001161070 Calomela Species 0.000 claims description 6
- 210000002969 egg yolk Anatomy 0.000 claims description 6
- 235000013345 egg yolk Nutrition 0.000 claims description 6
- 235000013601 eggs Nutrition 0.000 claims description 6
- 241000287828 Gallus gallus Species 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 210000004681 ovum Anatomy 0.000 claims description 3
- 235000011837 pasties Nutrition 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 2
- 201000004624 Dermatitis Diseases 0.000 abstract description 8
- 208000010668 atopic eczema Diseases 0.000 abstract description 6
- 206010043866 Tinea capitis Diseases 0.000 abstract description 2
- 206010067197 Tinea manuum Diseases 0.000 abstract description 2
- 230000001154 acute effect Effects 0.000 abstract description 2
- 210000002683 foot Anatomy 0.000 abstract description 2
- 229910052753 mercury Inorganic materials 0.000 abstract description 2
- 201000004647 tinea pedis Diseases 0.000 abstract description 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- 241000244987 Daiswa polyphylla Species 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 1
- 229940075397 calomel Drugs 0.000 abstract 1
- ZOMNIUBKTOKEHS-UHFFFAOYSA-L dimercury dichloride Chemical compound Cl[Hg][Hg]Cl ZOMNIUBKTOKEHS-UHFFFAOYSA-L 0.000 abstract 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 1
- 239000002674 ointment Substances 0.000 description 5
- 206010040882 skin lesion Diseases 0.000 description 5
- 231100000444 skin lesion Toxicity 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- CZCUIGLMMGPMLC-UHFFFAOYSA-N 5,8-dihydroxy-2-(4-methylpentyl)naphthalene-1,4-dione Chemical compound C1=CC(O)=C2C(=O)C(CCCC(C)C)=CC(=O)C2=C1O CZCUIGLMMGPMLC-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 206010015150 Erythema Diseases 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 241001071917 Lithospermum Species 0.000 description 2
- 206010039509 Scab Diseases 0.000 description 2
- WNFXUXZJJKTDOZ-HNNXBMFYSA-N [(1s)-1-(5,8-dihydroxy-1,4-dioxonaphthalen-2-yl)-4-methylpent-3-enyl] acetate Chemical compound C1=CC(O)=C2C(=O)C([C@@H](OC(C)=O)CC=C(C)C)=CC(=O)C2=C1O WNFXUXZJJKTDOZ-HNNXBMFYSA-N 0.000 description 2
- 206010000496 acne Diseases 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 231100000321 erythema Toxicity 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- WNFXUXZJJKTDOZ-UHFFFAOYSA-N shikonin acetate Natural products C1=CC(O)=C2C(=O)C(C(OC(C)=O)CC=C(C)C)=CC(=O)C2=C1O WNFXUXZJJKTDOZ-UHFFFAOYSA-N 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 241001480043 Arthrodermataceae Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 201000006082 Chickenpox Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- BVRYLTBIGIAADD-MRXNPFEDSA-N Isobutylshikonin Chemical compound C1=CC(O)=C2C(=O)C([C@@H](CC=C(C)C)OC(=O)C(C)C)=CC(=O)C2=C1O BVRYLTBIGIAADD-MRXNPFEDSA-N 0.000 description 1
- 241000533950 Leucojum Species 0.000 description 1
- 206010024438 Lichenification Diseases 0.000 description 1
- 241000187654 Nocardia Species 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- 241000130764 Tinea Species 0.000 description 1
- 241000223238 Trichophyton Species 0.000 description 1
- 241000223229 Trichophyton rubrum Species 0.000 description 1
- 206010046980 Varicella Diseases 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000019504 cigarettes Nutrition 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 230000037304 dermatophytes Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- BVRYLTBIGIAADD-UHFFFAOYSA-N isobutyryl shikonin Natural products C1=CC(O)=C2C(=O)C(C(CC=C(C)C)OC(=O)C(C)C)=CC(=O)C2=C1O BVRYLTBIGIAADD-UHFFFAOYSA-N 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 229940040145 liniment Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention relates to a drug with effects of clearing damp and relieving detoxify and killing parasites and relieving itching, which is prepared from the following bulk drugs in parts by weight: 10-30 of Rhizoma Coptidis, 10-40 of mercury, 1-10 of borneol, 1-10 of calomel, 5-20 of Pericarpium Zanthoxyli, 10-30 of Paris Polyphylla and 5-30 of Radix Arnebiae. The invention also relates to a preparation method of the drug. The drug provided by the invention is suitable for curing acute eczema, subacute eczema, chronic eczema, tinea capitis, tinea manus and pedis and the like.
Description
Technical field
The present invention relates to tcm field, relate in particular to medicament of a kind of damp eliminating detoxifcation, killing parasites for relieving itching and preparation method thereof.
Background technology
Eczema is because the skin lesion disease that wind, heat, dry, wet invasion and attack skin cause shows as the pleomorphism erythra, has erythema, pimple, water scar, sepage, knot to be crazy about, to soak into, to chap etc., and pruritus is obvious; After chickenpox is scratched, form rotten to the corn face, and obvious sepage is arranged; During with infection, inflammation is more obvious; Wound surface has a large amount of purulent secretions or pus crusts, and pus gathers under the crust.
Summary of the invention
The medicament that the purpose of this invention is to provide a kind of damp eliminating detoxifcation, killing parasites for relieving itching.
The present invention also aims to provide the medicaments preparation method of this damp eliminating detoxifcation, killing parasites for relieving itching.
In order to realize purpose of the present invention, the invention provides the medicament of a kind of damp eliminating detoxifcation, killing parasites for relieving itching, it is characterized in that it is to be made by weight by following bulk drugs: Rhizoma Coptidis 10-30 part, hydrargyrum 10-40 part, Borneolum Syntheticum 1-10 part, Calomelas 1-10 part, Pericarpium Zanthoxyli 5-20 part, Rhizoma Paridis 10-30 part and Radix Arnebiae (Radix Lithospermi) 5-30 part.
Preferably, the medicament of damp eliminating detoxifcation of the present invention, killing parasites for relieving itching is to be made by weight by following bulk drugs: 10 parts of 15 parts of Rhizoma Coptidis, 10 parts of hydrargyrums, 3 parts of Borneolum Syntheticums, 5 parts of Calomelass, 10 parts in Pericarpium Zanthoxyli, 15 parts of Rhizoma Paridis and Radix Arnebiae (Radix Lithospermi)s.
In this article, Calomelas is flaky crystal, and shape is like snowflake.Color is white, and silvering is arranged.Body is light, and hands is twisted with the fingers and easily is broken into white powder., sheet pure white with the Calomelas powder be big, become clear, be acicular crystal, light weight, no mercury bead person for good.Water insoluble and sour, be placed on the iron plate and heat, then gradually become yellow, turn to blue or green cigarette at last, leave no trace.Hydro-oxidation potassium liquid is separated out the black oxidation mercurous, add the ammonia jolting it, then become black.Its to trichophyton, permitted dermatophytess such as blue achorion, Du's big belly microspore tinea bacterium difficult to understand, epidermophyton rubrum, star-shaped nocardia in various degree inhibitory action all arranged.
Radix Arnebiae (Radix Lithospermi) (formal name used at school: Lithospermum erythrorhizon) be the plant of Boraginaceae Lithospermum.Have another name called mountain Radix Arnebiae (Radix Lithospermi), Zi Dan, Radix Arnebiae (Radix Lithospermi), be distributed in the ground such as Liaoning, Shanxi, Hunan, Gansu, Shandong, Hubei, Guangxi, Sichuan, Shaanxi, Guizhou, Jiangxi, Hebei, Henan of Japan, Korea and China's Mainland, grow in 50 meters of height above sea level to 2,500 meters area, be grown in patana, at present as yet not by artificial introducing and planting more.Be a kind of of Chinese herbal medicine, uproot spring and autumn, removes residual stem and earth (not washing with water, in case fade), dries or the low baking temperature oven dry, gives birth to and use.The root of Radix Arnebiae (Radix Lithospermi) all contains pigment, Acetyl-shikonin Acetylshikonin, alkannan, isobutyryl shikonin etc. with spending.
Preferably, medicament of the present invention is unguentum, egg ointment, ointment or liniment.
The present invention also provides the medicaments preparation method of a kind of damp eliminating detoxifcation, killing parasites for relieving itching, and this method comprises:
1) gets Rhizoma Coptidis, hydrargyrum, Borneolum Syntheticum, Calomelas, Pericarpium Zanthoxyli, Rhizoma Paridis and Radix Arnebiae (Radix Lithospermi), pulverize, cross 120 mesh sieves, obtain the crude drug powder behind the autoclave sterilization; And
2) egg is boiled, remove Ovum crusta Gallus domesticus and albumen, egg yolk is put into pot, decoct with high heat earlier, use instead then and at a simmerly become black so that oil is eliminated to egg yolk, cooling adds 1) in the crude drug powder that obtains to be modulated into pasty state.
Term " intense fire " and " slow fire " are the Chinese materia medica nouns, when boiling medicine how first force hereinafter, i.e. slow fire behind the first very hot oven.In this article, " intense fire " is 80 ℃ and decocts, and " slow fire " is 60 ℃ and decocts.
Medicament of the present invention is suitable for treating acute eczema, subacute eczema and chronic eczema, tinea capitis, tinea manus and pedis etc.
The specific embodiment
Below the invention will be further described for the description by the specific embodiment, but this is not to be limitation of the present invention, those skilled in the art are according to basic thought of the present invention, can make various modifications or improvement, but only otherwise break away from basic thought of the present invention, all within the scope of the present invention.
The preparation of embodiment 1 egg ointment of the present invention
Get Rhizoma Coptidis 15 grams, Borneolum Syntheticum 3 grams, Calomelas 5 grams, Pericarpium Zanthoxyli 10 grams, Rhizoma Paridis 15 grams and Radix Arnebiae (Radix Lithospermi) 10 grams, pulverize, add hydrargyrum 10 grams, cross 120 mesh sieves, obtain the crude drug powder behind the autoclave sterilization.Get 15 pieces in egg (800 gram), boil, remove Ovum crusta Gallus domesticus and albumen, egg yolk is put into pot, decoct 2 minutes with high heat earlier, use slow fire then instead and decoct 10 minutes, become black so that oil is eliminated to egg yolk, cooling adds 1) in the crude drug powder that obtains to be modulated into pasty state.
Experimental example
Diagnostic criteria
All patients all observe and add up by unified scientific research and design, and reference " new Chinese medicine clinical research guideline " eczema diagnostic criteria (Ministry of Health of the People's Republic of China. new Chinese medicine clinical research guideline [S] .1997,91-93.).Clinical symptoms is local erythema, pimple, squama, incrustation, part lichenification, violent pruritus.
Choose patient's 50 examples that meet above-mentioned standard, male 25 examples, women 25 examples; Age 18-54 year, average 34.5 years old.
During use, use normal saline to clean the affected part earlier, use the egg ointment of preparation among the embodiment 1 to be applied to the affected part equably then, be as the criterion to cover the affected part fully.Sooner or later respectively be coated with 1 time every day, is coated with 5 days continuously.
Criterion of therapeutical effect
Cure: skin lesion all disappears, the pruritus transference cure.Produce effects: skin lesion obviously disappears or major part disappears, and pruritus obviously alleviates.Effectively: skin lesion partly disappears, and the pruritus symptom makes moderate progress.Invalid: skin lesion disappears not obvious or does not disappear, and pruritus is not seen and alleviated or clinical symptoms worsens.
Through 5 days treatment, all patients all met the criterion of therapeutical effect of healing, and did not find tangible untoward reaction in the therapeutic process.
Claims (2)
1. the medicament of a damp eliminating detoxifcation, killing parasites for relieving itching is characterized in that it is to be made by weight by following bulk drugs: 10 parts of 15 parts of Rhizoma Coptidis, 10 parts of hydrargyrums, 3 parts of Borneolum Syntheticums, 5 parts of Calomelass, 10 parts in Pericarpium Zanthoxyli, 15 parts of Rhizoma Paridis and Radix Arnebiae (Radix Lithospermi)s.
2. the medicaments preparation method of the described damp eliminating detoxifcation of claim 1, killing parasites for relieving itching, this method comprises:
1) gets Rhizoma Coptidis, hydrargyrum, Borneolum Syntheticum, Calomelas, Pericarpium Zanthoxyli, Rhizoma Paridis and Radix Arnebiae (Radix Lithospermi), pulverize, cross 120 mesh sieves, obtain the crude drug powder behind the autoclave sterilization; And
2) egg is boiled, remove Ovum crusta Gallus domesticus and albumen, egg yolk is put into pot, decoct with high heat earlier, use instead then and at a simmerly become black so that oil is eliminated to egg yolk, cooling adds 1) in the crude drug powder that obtains to be modulated into pasty state.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210142860 CN102631523B (en) | 2012-05-10 | 2012-05-10 | Drug with effects of clearing damp and relieving detoxify and killing parasites and relieving itching, as well as preparation method of drug |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210142860 CN102631523B (en) | 2012-05-10 | 2012-05-10 | Drug with effects of clearing damp and relieving detoxify and killing parasites and relieving itching, as well as preparation method of drug |
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| Publication Number | Publication Date |
|---|---|
| CN102631523A CN102631523A (en) | 2012-08-15 |
| CN102631523B true CN102631523B (en) | 2013-07-10 |
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| CN 201210142860 Expired - Fee Related CN102631523B (en) | 2012-05-10 | 2012-05-10 | Drug with effects of clearing damp and relieving detoxify and killing parasites and relieving itching, as well as preparation method of drug |
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| CN113925907B (en) * | 2020-11-14 | 2023-09-15 | 四川省川科中医药产业发展有限公司 | Antibacterial, anti-inflammatory and antiallergic composition, and preparation method and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100360160C (en) * | 2005-08-31 | 2008-01-09 | 赵运荣 | Medicine for treating dermatosis and its prepn |
| CN100488518C (en) * | 2006-02-17 | 2009-05-20 | 林则都 | Psoriasis and eczema-treating Chinese traditional medicine |
| CN102048850A (en) * | 2010-12-24 | 2011-05-11 | 国药控股深圳中药有限公司 | Traditional Chinese medicine external preparation for curing infantile eczema and preparing method thereof |
-
2012
- 2012-05-10 CN CN 201210142860 patent/CN102631523B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100360160C (en) * | 2005-08-31 | 2008-01-09 | 赵运荣 | Medicine for treating dermatosis and its prepn |
| CN100488518C (en) * | 2006-02-17 | 2009-05-20 | 林则都 | Psoriasis and eczema-treating Chinese traditional medicine |
| CN102048850A (en) * | 2010-12-24 | 2011-05-11 | 国药控股深圳中药有限公司 | Traditional Chinese medicine external preparation for curing infantile eczema and preparing method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 周丹.川椒冰片油治疗阴囊湿疹.《四川中医》.1990,第11卷43. |
| 川椒冰片油治疗阴囊湿疹;周丹;《四川中医》;19901130;第11卷;43 * |
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