CN102629066A - Laser source device of coherent anti-Stokes Raman scattering microscopic system and production method thereof - Google Patents
Laser source device of coherent anti-Stokes Raman scattering microscopic system and production method thereof Download PDFInfo
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- CN102629066A CN102629066A CN201210097993XA CN201210097993A CN102629066A CN 102629066 A CN102629066 A CN 102629066A CN 201210097993X A CN201210097993X A CN 201210097993XA CN 201210097993 A CN201210097993 A CN 201210097993A CN 102629066 A CN102629066 A CN 102629066A
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Abstract
The invention discloses a laser source device of coherent anti-Stokes Raman scattering microscopic system, which comprises: an ultrashort pulse fiber laser for providing the pumping light of a parametric amplifier and the Stokes light required by the process of coherent anti-Stokes Raman scattering process; a tunable continuous light semiconductor laser and a fiber amplifier for amplifying the output light of the tunable continuous light semiconductor laser, wherein the light amplified is regarded as the seed light of the parametric amplifier; a light beam combiner for spatially combing the pumping light and the seed light of the parametric amplifier; a first nonlinear crystal and a second nonlinear crystal for sequentially receiving the light beams from the light beam combiner, wherein the two nonlinear crystals are respectively regarded as the parametric amplifier and the frequency multiplier for the seed light; a collimating focusing device arranged between the first nonlinear crystal and the second nonlinear crystal and a collimating device arranged behind the second nonlinear crystal; and a low-pass filter arranged behind the collimating device and used for filtering out the pumping light and the Stokes light required by the process of coherent anti-Stokes Raman scattering.
Description
Technical field
The invention belongs to the micro-field of nonlinear optics, particularly relate to a kind of device and production method of LASER Light Source of coherent anti-stokes raman scattering microscopic system.
Background technology
Coherent Raman scattering is micro-; Comprise coherent anti-stokes raman scattering (Coherent anti-Stokes Raman Scattering; CARS) micro-and stimulated Raman scattering (Stimulated Raman Scattering; SRS) micro-, have the mark of need not, high sensitivity, can realize advantage such as three-dimensional imaging potential application is arranged in biomedical imaging field in real time.
Yet the advantage of relevant Raman microtechnic is a cost with its complicated exciting light source.For realizing the coherent Raman scattering micro-imaging, need to adopt two bundle ultrashort light pulses time synchronized, tunable wave length, high-octane to encourage.When the wavelength difference of two bundle exciting lights overlapped with the characteristic Raman peaks of certain material in the biological sample, the Raman scattering signal was greatly strengthened, and produced the coherent Raman scattering signal.Take all factors into consideration factors such as the sample penetration degree of depth, system's transmitance and system complexity in the reality, generally stokes light is chosen near the 1040nm, and pump light is chosen as wavelength-tunable in 690nm～990nm scope.
The progress of relevant Raman microtechnic is limited by the development of exciting light source; Related content can be referring to document " relevant Stokes Raman scattering microscopy: the chemical imaging of biology and medical science (Conor L.Evans and X.Sunney Xie; Coherent anti-Stokes Raman scattering microscopy:chemical imaging for biology and medicine; Annu.Rev.Anal.Chem., 1:883 909 (2008)) ".How to solve the stationary problem between two bundle excitation pulses, affect system cost and complexity.Initial people adopt the scheme of two solid state lasers of phase locking, have obtained synchronous laser pulse, but its feedback control circuit very complicated, involve great expense.Subsequently, the optical parametric oscillator scheme of solid state laser and synchronous pump thereof occurred, can directly obtain synchronizing pulse, but wherein optical parametric oscillator has still needed feedback control circuit, system architecture is complicated, cost is expensive.In addition, time lens (Time lens) technology also is used to obtain synchronizing pulse, but it needs complicated feedback control circuit equally, and the train of impulses that is produced has bigger noise floor.It is thus clear that such scheme all fails to effectively reduce system cost and complexity.
People such as Chao-Yu Chung have proposed a kind of scheme (Chao-Yu Chung, Yen-Yin Lin, Kuo-Yu Wu that obtains the driving pulse of CARS microscopic system with the parameter amplifier of solid state laser and pumping thereof; Wan-Yu Tai; Shi-Wei Chu, Yao-Chang Lee, Yeukuang Hwu; Yin-Yu Lee; Coherent anti-Stokes Raman scattering microscopy using a single-pass picoseconds supercontinuum-seeded optical parametric amplifier, Opt Express 18 (6), 6116-6122 (2010)).Near infrared light (1064nm) pulse part that in this scheme solid state laser is produced is coupled into photonic crystal fiber and produces super continuous spectrums, thereby seed light (about 800nm) is provided for parameter amplifier.Remainder is then after frequency multiplication, as the pump light (532nm) of parameter amplifier.In the said process, the new wavelength pulse that is produced (about 800nm) is synchronous with former near infrared pulse (1064nm) automatically, so need not feedback control circuit.But because the power spectrum density of super continuous spectrums is little, with its kind period of the day from 11 p.m. to 1 a.m as parameter amplifier, the conversion efficiency of parametric process is low, has reduced the output power of parameter amplifier.In addition, adopted solid state laser to produce near infrared pulse (1064nm) in this system, complex structure, cost an arm and a leg.
In addition, all need adopt pump light and the Stokes photosynthetic bundle of dichroscope in the such scheme, the two is excited so that sample is carried out conllinear at space coincidence CARS.And the pump light of CARS and the compensation of the optical path difference between stokes light also need be introduced optical delay line, go up the driving pulse that overlaps with the acquisition time.The introducing of above-mentioned space optical path can increase system complexity undoubtedly, reduce the stability of system.
Therefore, need the urgent technical matters that solves of those skilled in the art to propose a kind of effective measures exactly at present, compact conformation, LASER Light Source with low cost are provided for coherent Raman scattering is micro-.
Summary of the invention
The present invention provides a kind of laser light-source device of coherent anti-stokes raman scattering microscopic system, with the problems referred to above of the LASER Light Source of the existing Raman scattering microscopic system that solves.The present invention provides the production method of the micro-LASER Light Source of a kind of coherent anti-stokes raman scattering simultaneously.
In order to address the above problem, the invention discloses a kind of laser light-source device of coherent anti-stokes raman scattering microscopic system, comprising:
The ultrashort pulse fiber laser of parameter amplifier pump light and the required stokes light of coherent anti-stokes raman scattering process is provided;
Tunable continuous light semiconductor laser and the fiber amplifier that the output light of tunable continuous light semiconductor laser is amplified, the light after the amplification is as the seed light of parameter amplifier;
The seed light of said pump light and parameter amplifier is closed the light beam bundling device of bundle in the space;
First nonlinear crystal of receiving beam bundling device light beam and second nonlinear crystal in order, two nonlinear crystals as the parameter amplifier and the frequency multiplier of seed light, selectively amplify and frequency multiplication different-waveband seed light parameter respectively;
Be arranged at collimation focus device and second nonlinear crystal collimating element afterwards between first nonlinear crystal and second nonlinear crystal; The seed light response that said collimation focus device amplifies wave band to parameter during work, collimating element is to the seed light response of frequency multiplication wave band;
Be arranged at said collimating element low-pass filter afterwards, leach required pump light of coherent anti-stokes raman scattering process and stokes light, can obtain the micro-LASER Light Source of coherent Raman scattering.
Optional, said ultrashort pulse fiber laser is femtosecond pulse fiber laser or Picopulse optical fiber laser.
Optional, said ultrashort pulse fiber laser is ultrashort pulse ytterbium-doping optical fiber laser or ultrashort pulse neodymium-doped fiber laser.
Optional, said tunable continuous light semiconductor laser output wavelength scope is 1510nm to 1640nm.
Optional, said fiber amplifier is an Erbium-Doped Fiber Amplifier (EDFA).
Optional; Also comprise the 1/1st wave plate and the 1/2nd wave plate; First condenser lens and second condenser lens, said seed light is parallel through 1/2nd wave plate adjustment polarization state respectively with the pumping combiner before, and focuses on through two condenser lenses.
Optional, said first nonlinear crystal is a kind of in lithium triborate crystal, periodic polarized lithium columbate crystal, period polarized magnesium oxide doped lithium niobate crystal, the period polarized superlattice lithium tantalate;
Said second nonlinear crystal is a kind of in lithium triborate crystal, periodic polarized lithium columbate crystal, period polarized magnesium oxide doped lithium niobate crystal, the period polarized superlattice lithium tantalate.
Optional, said first nonlinear crystal and second nonlinear crystal all are arranged in the temperature controlling stove, and the temperature of adjustment temperature controlling stove is to realize phase matching.
Optional, said low-pass filter is low pass filters or dichroscope.
The present invention also provides the production method of the micro-LASER Light Source of a kind of coherent anti-stokes raman scattering, comprising:
The output light of tunable continuous light semiconductor laser is amplified through fiber amplifier, as seed light;
With the output light of ultrashort pulse fiber laser as pump light;
Said seed light and pump light are together focused to first nonlinear crystal, and the wave band that has selection that seed light is needed by this first nonlinear crystal carries out the parameter amplification;
The output pulse and the remaining pump light pulse of gained focus to second nonlinear crystal in the lump after will being amplified by parameter, and frequency multiplication is carried out in the output pulse after parameter is amplified;
To leach also collimation by the pulse and the remaining pump light pulse of frequency multiplication gained, can obtain the LASER Light Source of coherent anti-stokes raman scattering microscopic system.
Compared with prior art; It is that parameter amplifier provides seed light that the laser light-source device of coherent anti-stokes raman scattering microscopic system of the present invention adopts tunable continuous light semiconductor laser; Can obtain synchronizing pulse dexterously; Improve the transformation efficiency of parametric process simultaneously, reduced system cost and complexity; Reach the scheme of its output being carried out frequency multiplication through the employing parameter amplifier, the driving pulse that directly obtains the space, overlaps on the time, and need not to introduce the additional space light path, simplify system architecture, increased system stability; Adopt ultrashort pulse fiber laser to produce the required stokes light of coherent Raman scattering and the pump light of parameter amplifier, system architecture is compact, with low cost.
Description of drawings
Fig. 1 is the synoptic diagram of one of them embodiment of the laser light-source device of coherent anti-stokes raman scattering microscopic system of the present invention;
Fig. 2 is the thermal tuning curve of parameter amplifier MgO:PPLN under the different polarization cycles;
Fig. 3 is the thermal tuning curve of frequency-doubling crystal MgO:PPLN under the different polarization cycles.
Embodiment
For make above-mentioned purpose of the present invention, feature and advantage can be more obviously understandable, below in conjunction with accompanying drawing and embodiment the present invention done further detailed explanation.
Fig. 1 is the synoptic diagram of one of them embodiment of the laser light-source device of coherent anti-stokes raman scattering microscopic system of the present invention.
Please referring to Fig. 1, the present embodiment device comprises ultrashort pulse fiber laser 1-1, is used to produce the pump light of parameter amplifier, and provides the coherent anti-stokes raman scattering process required stokes light.
Light beam bundling device 7 is used for the light of two bundle different wave lengths is closed bundle in the space;
Tunable continuous light semiconductor laser 1-2 is used to obtain the seed light of parameter amplifier.Fiber amplifier 1-3 is used for the output of tunable continuous light semiconductor laser 1-2 is amplified, and the light after the amplification is called the seed light of parameter amplifier.
First nonlinear crystal 9, second nonlinear crystal 13 are respectively applied for and carry out that parameter amplifies, frequency multiplication.
Lens 10 and 11 are formed the collimation focus devices, the focusing that collimates of the seed light after being used for first nonlinear crystal, 9 parameters are amplified.
Collimation lens 14 is used for the frequency doubled light and the former residual pump light of second nonlinear crystal, 13 frequency multiplication gained are collimated.
Low-pass filter 15 is used for the not seed light of frequency multiplication wave band of filtering.
When forming concrete light path, the device of present embodiment also comprises following device:
Catoptron 1 is used for reflected light path, changes ultrashort pulse fiber laser 1-1 output direction of light, so that whole optical path is more compact, this catoptron 1 can certainly be set.
The 1/1st wave plate 2 (wherein first and second of this instructions just to the identical device of differentiation title, but not representes ordinal number), the 1/2nd wave plate 5 are used to adjust polarization state.
First lens 3, second lens 6 are used for light beam is focused on.
Optical fiber collimator 4 is used for output with the Erbium-Doped Fiber Amplifier (EDFA) 1-3 output that collimates.
First temperature controlling stove 8 and second temperature controlling stove 12 are used to adjust and keep first nonlinear crystal 9 and second nonlinear crystal 13 in appropriate working temperature, obtain maximum conversion efficient to realize phase matching.
Example below in conjunction with concrete describes.
Said ultrashort pulse fiber laser 1-1 is ultrashort pulse ytterbium-doping optical fiber laser (also can be the ultrashort pulse neodymium-doped fiber laser) in the present embodiment, can obtain the output light of centre wavelength 1040nm, full width at half maximum～3ps, pulse energy 10nJ.As the pump light of parameter amplifier 9, and provide the coherent anti-stokes raman scattering process required stokes light.Ultrashort pulse fiber laser 1-1 can also be the picosecond laser of femto-second laser or other wave band.
Tunable continuous light semiconductor laser 1-2 is Agilent (Aglient) company, model 8164A, the laser instrument of output wavelength 1510-1640nm.Fiber amplifier 1-3 is an Erbium-Doped Fiber Amplifier (EDFA), is exported by optical fiber collimator 4 collimations through the light of its amplification, as the seed light of follow-up parameter amplifier.
The 1/1st wave plate 2 is adjusted above-mentioned pump light respectively with the 1/2nd wave plate 5 and is made that with the seed polarization state of light its polarization state is parallel; And adopt first lens 3 and second lens 6 to focus on; Close bundle to the first nonlinear crystal 9 through light beam bundling device 7 then, this first nonlinear crystal 9 is as parameter amplifier.What wherein, said first nonlinear crystal 9 can be in three lithium borate lbo crystals, periodic polarized lithium niobate PPLN crystal, period polarized doped with magnesia lithium niobate MgO:PPLN crystal, the period polarized superlattice lithium tantalate PPLST crystal is a kind of.Be specially multipolarization cycle MgO:PPLN crystal (its polarization cycle comprises 29.6um, 30um and 30.4um) in the present embodiment, select the waveguide of required polarization cycle and adjust first temperature controlling stove 8 to the proper temperature and carry out parameter and amplify (the thermal tuning curve of parameter amplifier MgO:PPLN is as shown in Figure 2 under the different polarization cycles).
After scioptics 10 will be collimated by the output light of parameter amplifier, adopt lens 11 that light beam is focused to second nonlinear crystal 13.Said second nonlinear crystal 13 is as frequency multiplier.Said second nonlinear crystal 13 can be in three lithium borate lbo crystals, periodic polarized lithium niobate PPLN crystal, period polarized doped with magnesia lithium niobate MgO:PPLN crystal, the period polarized superlattice lithium tantalate PPLST crystal a kind of.Be specially multipolarization cycle MgO:PPLN crystal (polarization cycle comprises 18.2um, 18.8um, 19.4um, 20.0um, 20.6um and 21.2um) in the present embodiment, select the waveguide of required polarization cycle and adjust second temperature controlling stove 15 to appropriate temperature and carry out frequency multiplication (the thermal tuning curve of frequency-doubling crystal MgO:PPLN is as shown in Figure 3 under the different polarization cycles).Can obtain to contain the pulse of 775nm to 820nm.
To collimate with collimation lens 14 by the output gloss of frequency-doubling crystal, and employing low-pass filter 15 leaches the pulse that contains wavelength 775nm to 820nm, reaches wavelength 1040nm.Wherein, said low-pass filter 15 is low pass filters or dichroscope.
Amplifying and frequency multiplication because the polarization cycle of first nonlinear crystal and second nonlinear crystal only carries out parameter to seed light, and pump light is not changed, is the pulse of 1040nm so the output light after low-pass filter 15 also comprises wavelength.
Promptly can be used as the micro-LASER Light Source of coherent Raman scattering after will containing the pulse coupling of pulse and wavelength 1040nm of 775nm to 820nm, for example be coupled to microscope 1-4 and can carry out the CARS micro-imaging.Behind signal processing unit 1-5, transfer to computing machine 1-6 and can carry out the visual processing of Denging micro-imaging.
The output wavelength (scope 1510-1640nm) of tuning tunable continuous light semiconductor laser 1-2, said apparatus can be to raman characteristic peak at 2579cm
-1To 3846cm
-1The sample of scope carries out the coherent Raman scattering micro-imaging.
Be illustrated below, (wherein the characteristic peak of CH2 key is at 2845cm like content of oil and grease in the desire testing biological specimen
-1Near), can the output wavelength of tunable continuous light semiconductor laser be arranged on 1605nm.With reference to Fig. 2, can select that polarization cycle is the waveguide of 30.4um in the MgO:PPLN crystal 9 for use, and its temperature is set is 120 ℃, parameter amplifier can consume the energy of 1040nm pulse and obtain 1605nm pulse (wherein the group velocity mismatch of the two is 111fs/mm) this moment.With reference to figure 3, select that polarization cycle is the waveguide of 20.6um in the MgO:PPLN crystal 13 for use, and its temperature is set is 102.8 ℃, 1605nm pulse generation this moment frequency multiplication obtains the 802.5nm pulse.And the 1040nm pulse do not change (the group velocity mismatch between itself and frequency doubled light is 164fs/mm, before having compensated in the parameter amplifier walk from).Lens 14 collimations are adopted in 802.5nm pulse that frequency multiplication obtained and 1040nm pulse, and adopt low-pass filter 15 to leach the pulse of 802.5nm and 1040nm, can obtain the synchronizing pulse of time, space coincidence, because the CARS micro-imaging of grease.
Thus it is clear that, in the device of present embodiment,, can obtain synchronizing pulse automatically in the seed light wavelength, so need not to consider the stationary problem between the two-beam because pulse pump light carries out the parameter amplification to continuous seed light in the parameter amplifier.And, can obtain high parameter transformation efficiency because seed light has the high power spectral density continuously.
And; When remaining pump light pulse is transmitted in frequency-doubling crystal with the seed optical pulse that is obtained through the parameter amplification in the lump in the parameter amplifier; Because the polarization cycle of frequency-doubling crystal or temperature only are arranged on seed optical pulse is carried out frequency multiplication, and the pump light pulse does not change.So the pump light pulse is experienced identical light path with the pulse of frequency multiplication gained, the two coincidence on the space, and need not adjustment; In addition; In the parameter amplifier pump light pulse and the parameter that produces amplify to walk to leave between the seed optical pulse of back; Can compensate pump light pulse in the frequency-doubling crystal and produce to walk to leave between the frequency multiplication afterpulse; So make to be similar in time with the pump light pulse to overlap, and need not to compensate optical path difference through the frequency-doubling crystal afterpulse.
To sum up, in the method for the present invention, adopting tunable continuous light semiconductor laser is that parameter amplifier provides seed light, can obtain synchronizing pulse dexterously, has improved the transformation efficiency of parametric process simultaneously, has reduced system cost and complexity; Reach the scheme of its output being carried out frequency multiplication through the employing parameter amplifier, the driving pulse that directly obtains the space, overlaps on the time, and need not to introduce the additional space light path, simplify system architecture, increased system stability; Adopt ultrashort pulse fiber laser to produce the required stokes light of coherent Raman scattering and the pump light of parameter amplifier, system architecture is compact, with low cost.
Though the present invention with preferred embodiment openly as above; But it is not to be used for limiting the present invention; Any those skilled in the art are not breaking away from the spirit and scope of the present invention; Can make possible change and modification, so protection scope of the present invention should be as the criterion with the scope that claim of the present invention was defined.
Claims (10)
1. the laser light-source device of a coherent anti-stokes raman scattering microscopic system is characterized in that comprising:
The ultrashort pulse fiber laser of parameter amplifier pump light and the required stokes light of coherent anti-stokes raman scattering process is provided;
Tunable continuous light semiconductor laser and the fiber amplifier that the output light of tunable continuous light semiconductor laser is amplified, the light after the amplification is as the seed light of parameter amplifier;
The seed light of said pump light and parameter amplifier is closed the light beam bundling device of bundle in the space;
First nonlinear crystal of receiving beam bundling device light beam and second nonlinear crystal in order, two nonlinear crystals as the parameter amplifier and the frequency multiplier of seed light, selectively amplify and frequency multiplication different-waveband seed light parameter respectively;
Be arranged at collimation focus device and second nonlinear crystal collimating element afterwards between first nonlinear crystal and second nonlinear crystal; The seed light response that said collimation focus device amplifies wave band to parameter during work, collimating element is to the seed light response of frequency multiplication wave band;
Be arranged at said collimating element low-pass filter afterwards, leach required pump light of coherent anti-stokes raman scattering process and stokes light, can obtain the micro-LASER Light Source of coherent Raman scattering.
2. the laser light-source device of coherent anti-stokes raman scattering microscopic system as claimed in claim 1 is characterized in that: said ultrashort pulse fiber laser is femtosecond pulse fiber laser or Picopulse optical fiber laser.
3. the laser light-source device of coherent anti-stokes raman scattering microscopic system as claimed in claim 1 is characterized in that: said ultrashort pulse fiber laser is ultrashort pulse ytterbium-doping optical fiber laser or ultrashort pulse neodymium-doped fiber laser.
4. the laser light-source device of coherent anti-stokes raman scattering microscopic system as claimed in claim 1 is characterized in that: said tunable continuous light semiconductor laser output wavelength scope is 1510nm to 1640nm.
5. the laser light-source device of coherent anti-stokes raman scattering microscopic system as claimed in claim 1 is characterized in that: said fiber amplifier is an Erbium-Doped Fiber Amplifier (EDFA).
6. the laser light-source device of coherent anti-stokes raman scattering microscopic system according to claim 1; It is characterized in that: also comprise the 1/1st wave plate and the 1/2nd wave plate; First condenser lens and second condenser lens; Said seed light is parallel through 1/2nd wave plate adjustment polarization state respectively with the pumping combiner before, and focuses on through two condenser lenses.
7. the laser light-source device of coherent anti-stokes raman scattering microscopic system as claimed in claim 1 is characterized in that: said first nonlinear crystal is a kind of in lithium triborate crystal, periodic polarized lithium columbate crystal, period polarized magnesium oxide doped lithium niobate crystal, the period polarized superlattice lithium tantalate;
Said second nonlinear crystal is a kind of in lithium triborate crystal, periodic polarized lithium columbate crystal, period polarized magnesium oxide doped lithium niobate crystal, the period polarized superlattice lithium tantalate.
8. the laser light-source device of coherent anti-stokes raman scattering microscopic system according to claim 7; It is characterized in that: said first nonlinear crystal and second nonlinear crystal all are arranged in the temperature controlling stove, and the temperature of adjustment temperature controlling stove is to realize phase matching.
9. the laser light-source device of coherent anti-stokes raman scattering microscopic system according to claim 1 is characterized in that: said low-pass filter is low pass filters or dichroscope.
10. the production method of the LASER Light Source of a coherent anti-stokes raman scattering microscopic system is characterized in that comprising:
The output light of tunable continuous light semiconductor laser is amplified through fiber amplifier, as seed light;
With the output light of ultrashort pulse fiber laser as pump light;
Said seed light and pump light are together focused to first nonlinear crystal, and the wave band that has selection that seed light is needed by this first nonlinear crystal carries out the parameter amplification;
The output pulse and the remaining pump light pulse of gained focus to second nonlinear crystal in the lump after will being amplified by parameter, and frequency multiplication is carried out in the output pulse after parameter is amplified;
To leach also collimation by the pulse and the remaining pump light pulse of frequency multiplication gained, can obtain the LASER Light Source of coherent anti-stokes raman scattering microscopic system.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104283105A (en) * | 2014-10-17 | 2015-01-14 | 中国科学院上海光学精密机械研究所 | Method for compensating for phase mismatching caused by temperature variation through harmonic wave conversion device |
| CN104834149A (en) * | 2015-04-15 | 2015-08-12 | 天津大学 | Single-fiber-type CARS excitation source device and realization method based on two-stage non-linear tuning |
| CN108240979A (en) * | 2016-12-27 | 2018-07-03 | 深圳大学 | Coherent anti-stokes raman scattering micro imaging system and imaging method |
| CN111193176A (en) * | 2018-11-14 | 2020-05-22 | 方砾琳 | High-precision laser frequency adjusting and stabilizing system |
| CN111224311A (en) * | 2019-11-21 | 2020-06-02 | 中国航空制造技术研究院 | Hundred-nanosecond-level fast-switching dual-wavelength Raman laser |
| CN111934165A (en) * | 2020-08-26 | 2020-11-13 | 中国工程物理研究院激光聚变研究中心 | Ultrashort pulse generation method based on flight focus and plasma back Raman scattering |
| CN112285094A (en) * | 2020-12-30 | 2021-01-29 | 武汉光谷航天三江激光产业技术研究院有限公司 | CARS spectrum detection system and method based on line width adjustment |
| CN113552071A (en) * | 2021-08-26 | 2021-10-26 | 天津大学 | Photoacoustic imaging system |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100046039A1 (en) * | 2008-08-22 | 2010-02-25 | President And Fellows Of Harvard College | Microscopy imaging system and method employing stimulated raman spectroscopy as a contrast mechanism |
| WO2010071682A2 (en) * | 2008-12-20 | 2010-06-24 | Purdue Research Foundation | A multimodal platform for nonlinear optical microscopy and microspectroscopy |
| US20110282166A1 (en) * | 2009-12-18 | 2011-11-17 | The Regents Of The University Of California | System and Method for Efficient Coherence Anti-Stokes Raman Scattering Endoscopic and Intravascular Imaging and Multimodal Imaging |
-
2012
- 2012-04-05 CN CN201210097993.XA patent/CN102629066B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100046039A1 (en) * | 2008-08-22 | 2010-02-25 | President And Fellows Of Harvard College | Microscopy imaging system and method employing stimulated raman spectroscopy as a contrast mechanism |
| WO2010071682A2 (en) * | 2008-12-20 | 2010-06-24 | Purdue Research Foundation | A multimodal platform for nonlinear optical microscopy and microspectroscopy |
| US20110282166A1 (en) * | 2009-12-18 | 2011-11-17 | The Regents Of The University Of California | System and Method for Efficient Coherence Anti-Stokes Raman Scattering Endoscopic and Intravascular Imaging and Multimodal Imaging |
Non-Patent Citations (1)
| Title |
|---|
| SIMON LEFRANCOIS, LINGJIE KONG, DIMITRE OUZOUNOV,ET.AL: "《High-power picosecond fiber lasers for Raman microscopies》", 《PROC.OF SPIE》 * |
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| CN104283105B (en) * | 2014-10-17 | 2017-06-06 | 中国科学院上海光学精密机械研究所 | Cause the compensation method of phase mismatch to temperature change for harmonic conversion device |
| CN104834149A (en) * | 2015-04-15 | 2015-08-12 | 天津大学 | Single-fiber-type CARS excitation source device and realization method based on two-stage non-linear tuning |
| CN104834149B (en) * | 2015-04-15 | 2017-10-13 | 天津大学 | Single fiber type CARS excitation source apparatus and implementation method based on the non-linear tuning of twin-stage |
| CN108240979A (en) * | 2016-12-27 | 2018-07-03 | 深圳大学 | Coherent anti-stokes raman scattering micro imaging system and imaging method |
| CN108240979B (en) * | 2016-12-27 | 2023-10-27 | 深圳大学 | Coherent anti-stokes raman scattering microscopic imaging system and imaging method |
| CN111193176A (en) * | 2018-11-14 | 2020-05-22 | 方砾琳 | High-precision laser frequency adjusting and stabilizing system |
| CN111224311A (en) * | 2019-11-21 | 2020-06-02 | 中国航空制造技术研究院 | Hundred-nanosecond-level fast-switching dual-wavelength Raman laser |
| CN111934165A (en) * | 2020-08-26 | 2020-11-13 | 中国工程物理研究院激光聚变研究中心 | Ultrashort pulse generation method based on flight focus and plasma back Raman scattering |
| CN111934165B (en) * | 2020-08-26 | 2021-09-07 | 中国工程物理研究院激光聚变研究中心 | Ultrashort pulse generation method based on flight focus and plasma back Raman scattering |
| CN112285094A (en) * | 2020-12-30 | 2021-01-29 | 武汉光谷航天三江激光产业技术研究院有限公司 | CARS spectrum detection system and method based on line width adjustment |
| CN113552071A (en) * | 2021-08-26 | 2021-10-26 | 天津大学 | Photoacoustic imaging system |
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