CN102623874A - Laser source device for coherent Raman scattering microscope system and production method of laser source device - Google Patents
Laser source device for coherent Raman scattering microscope system and production method of laser source device Download PDFInfo
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- CN102623874A CN102623874A CN2012100978848A CN201210097884A CN102623874A CN 102623874 A CN102623874 A CN 102623874A CN 2012100978848 A CN2012100978848 A CN 2012100978848A CN 201210097884 A CN201210097884 A CN 201210097884A CN 102623874 A CN102623874 A CN 102623874A
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Abstract
The invention relates to a laser source device for a coherent Raman scattering microscope system. The laser source device comprises an ultrashort pulse fiber laser, a light beam splitter, a tunable continuous light semiconductor laser, an optical fiber amplifier, a first light beam combiner, a first nonlinear crystal, a second nonlinear crystal, a second light beam combiner, an optical delay line and a polarizer, wherein two split light beams are respectively used as Stokes light in a coherent Raman scattering process and pump light of a parametric amplifier; the optical fiber amplifier is used for amplifying output light of the continuous light semiconductor laser; the first light beam combiner is used for combining the pump light and seed light of the parametric amplifier in a space; the first nonlinear crystal and the second nonlinear crystal are used for sequentially receiving the light beam of the first light beam combiner, and the two nonlinear crystals are respectively used as a parametric amplifier and a frequency doubler; the second light beam combiner is used for combining the Stokes light and the output light of the frequency doubler in a space; the optical delay line is arranged in the light path of the Stokes light and used for carrying out light path adjustment on the Stokes light before the light beam combination of the second light beam combiner; and the polarizer is used for adjusting the polarization state.
Description
Technical field
The invention belongs to the micro-field of nonlinear optics, particularly relate to a kind of laser light-source device and production method of coherent Raman scattering microscopic system.
Background technology
Coherent Raman scattering is micro-; Comprise coherent anti-stokes raman scattering (Coherent anti-Stokes Raman Scattering; CARS) micro-and stimulated Raman scattering (Stimulated Raman Scattering; SRS) micro-, have the mark of need not, high sensitivity, can realize advantage such as three-dimensional imaging potential application is arranged in biomedical imaging field in real time.
Yet the advantage of relevant Raman microtechnic is a cost with its complicated exciting light source.For realizing the coherent Raman scattering micro-imaging, need to adopt two bundle ultrashort light pulses time synchronized, tunable wave length, high-octane to encourage.When the wavelength difference of two bundle exciting lights overlapped with the characteristic Raman peaks of certain material in the biological sample, the Raman scattering signal was greatly strengthened, and produced the coherent Raman scattering signal.Take all factors into consideration factors such as the sample penetration degree of depth, system's transmitance and system complexity in the reality, generally stokes light is chosen near the 1040nm, and pump light is chosen as wavelength-tunable in 690nm～990nm scope.
The progress of relevant Raman microtechnic is limited by the development of exciting light source; Related content can be referring to document " relevant Stokes Raman scattering microscopy: the chemical imaging of biology and medical science (Conor L.Evans and X.Sunney Xie; Coherent anti-Stokes Raman scattering microscopy:chemical imaging for biology and medicine; Annu.Rev.Anal.Chem., 1:883 909 (2008)) ".How to solve the stationary problem between two bundle excitation pulses, affect system cost and complexity.Initial people adopt the scheme of two solid state lasers of phase locking, have obtained synchronous laser pulse, but its feedback control circuit very complicated, involve great expense.Subsequently, the optical parametric oscillator scheme of solid state laser and synchronous pump thereof occurred, can directly obtain lock-out pulse, but wherein optical parametric oscillator has still needed feedback control circuit, system configuration is complicated, cost is expensive.In addition, time lens (Time lens) technology also is used to obtain lock-out pulse, but it needs complicated feedback control circuit equally, and the pulse train that is produced has bigger noise floor.It is thus clear that such scheme all fails to effectively reduce system cost and complexity.
People such as Chao-Yu Chung have proposed a kind of scheme (Chao-Yu Chung, Yen-Yin Lin, Kuo-Yu Wu that obtains the driving pulse of CARS microscopic system with the parametric amplifier of solid state laser and pumping thereof; Wan-Yu Tai; Shi-Wei Chu, Yao-Chang Lee, Yeukuang Hwu; Yin-Yu Lee; Coherent anti-Stokes Raman scattering microscopy using a single-pass picoseconds supercontinuum-seeded optical parametric amplifier, Opt Express 18 (6), 6116-6122 (2010)).Near infrared light (1064nm) pulse part that in this scheme solid state laser is produced is coupled into photonic crystal fiber and produces super continuous spectrums, thereby seed light (about 800nm) is provided for parametric amplifier.Remainder is then after frequency multiplication, as the pump light (532nm) of parametric amplifier.In the said process, the new wavelength pulse that is produced (about 800nm) is synchronous with former near-infrared pulse (1064nm) automatically, so need not feedback control circuit.But because the power spectral density of super continuous spectrums is little, with its kind period of the day from 11 p.m. to 1 a.m as parametric amplifier, the conversion efficiency of parametric process is low, has reduced the power output of parametric amplifier.In addition, adopted solid state laser to produce near-infrared pulse (1064nm) in this system, complex structure, cost an arm and a leg.
Therefore, need the urgent technical problem that solves of those skilled in the art to propose a kind of effective measures exactly at present, compact conformation, LASER Light Source with low cost are provided for coherent Raman scattering is micro-.
Summary of the invention
The present invention provides a kind of laser light-source device of coherent Raman scattering microscopic system, with the problems referred to above of the micro-LASER Light Source of the existing Raman scattering that solves.The present invention also provides a kind of production method of LASER Light Source of coherent Raman scattering microscopic system.
In order to address the above problem, the invention discloses a kind of laser light-source device of coherent Raman scattering microscopic system, comprising:
Ultrashort pulse fiber laser and to the beam splitter of the output light beam splitting of ultrashort pulse fiber laser, the two-beam after the beam splitting is respectively as the stokes light of coherent Raman scattering process and the pump light of parametric amplifier;
Tunable continuous light semiconductor laser and the fiber amplifier that the output light of tunable continuous light semiconductor laser is amplified, the light after the amplification is called the seed light of parametric amplifier;
The seed light of said pump light and parametric amplifier is closed the first light beam bundling device of bundle in the space;
Receive first nonlinear crystal and second nonlinear crystal of the first light beam bundling device light beam in order, two nonlinear crystals are respectively as parametric amplifier and frequency multiplier;
The output light of said stokes light and frequency multiplier is closed the second light beam bundling device of bundle in the space;
The polarizer that the optical delay line that is arranged in the light path of stokes light and before the second light beam bundling device closes bundle, stokes light is carried out the light path adjustment respectively and polarization state are adjusted.
Optional, said ultrashort pulse fiber laser is femtosecond pulse fiber laser or Picopulse optical fiber laser.
Optional, said ultrashort pulse fiber laser is ultrashort pulse ytterbium-doping optical fiber laser or ultrashort pulse neodymium-doped fiber laser.
Optional, said beam splitter energy splitting ratio 1: 3, wherein the light beam of 1/4th energy is as stokes light, and the light beam of 3/4ths energy is as pump light.
Optional, said tunable continuous light semiconductor laser output wavelength scope is 1510nm to 1640nm.
Optional, said fiber amplifier is an erbium-doped fiber amplifier.
Optional; Also comprise the 1/1st wave plate and the 1/2nd wave plate; First condenser lens and second condenser lens, said seed light is parallel through 1/2nd wave plate adjustment polarization state respectively with the pumping combiner before, and focuses on through two condenser lenses.
Optional, said first nonlinear crystal is a kind of in lithium triborate crystal, periodic polarized lithium columbate crystal, period polarized magnesium oxide doped lithium niobate crystal, the period polarized superlattice lithium tantalate;
Said second nonlinear crystal is a kind of in lithium triborate crystal, periodic polarized lithium columbate crystal, period polarized magnesium oxide doped lithium niobate crystal, the period polarized superlattice lithium tantalate.
Optional, said first nonlinear crystal and second nonlinear crystal all are arranged in the temperature controlling stove.
Optional, between said first nonlinear crystal and second nonlinear crystal, set gradually band pass filter and the 3rd condenser lens; Between said second nonlinear crystal and the second light beam bundling device, be provided with dichroic mirror; Wherein,
Said band pass filter is used to leach the pulsed light of the new Wavelength-converting of parametric amplifier gained, is projected to the 3rd condenser lens;
The pulsed light that said dichroic mirror is used for after the frequency multiplier frequency multiplication leaches, and is projected to the second light beam bundling device.
Optional, said polarizer is 1/2nd wave plates, is used to adjust the output light that the Stokes polarization state of light is parallel to second nonlinear crystal.
The present invention also provides the production method of the micro-LASER Light Source of a kind of coherent Raman scattering, comprising:
The output light of ultrashort pulse fiber laser is carried out beam splitting, and wherein a part is used to the stokes light that provides the coherent Raman scattering process required, and another part is as the pump light of parametric amplifier;
The output light of tunable continuous light semiconductor laser is amplified through fiber amplifier, and itself and pump light through the parametric amplifier of beam splitting are together focused to first nonlinear crystal carry out parameter and amplify;
To leach by the output pulse that parameter amplify the back gained, and focus to second nonlinear crystal and carry out frequency multiplication;
To leach by the pulsed light of frequency multiplication gained;
The light path and the polarization state of adjustment stokes light overlap the light pulse after said stokes light and the frequency multiplication in time, and polarization state parallels; And make the two at space coincidence.Can obtain the LASER Light Source of coherent Raman scattering microscopic system thus.
Compared with prior art; It is that parametric amplifier provides seed light that the laser light-source device of coherent Raman scattering microscopic system of the present invention adopts tunable continuous light semiconductor laser; Obtained lock-out pulse dexterously; And improved the transformation efficiency of parametric process, thereby reduced system cost and complexity; Adopt ultrashort pulse fiber laser to produce the required stokes light of coherent Raman scattering and the pump light of parametric amplifier, make system configuration compact, with low cost.
Description of drawings
Fig. 1 is the sketch map of one of them embodiment of the laser light-source device of coherent Raman scattering microscopic system of the present invention;
Fig. 2 is the thermal tuning curve of parametric amplifier MgO:PPLN under the different polarization cycles;
Fig. 3 is the thermal tuning curve of frequency-doubling crystal MgO:PPLN under the different polarization cycles.
Embodiment
For make above-mentioned purpose of the present invention, feature and advantage can be more obviously understandable, below in conjunction with accompanying drawing and embodiment the present invention done further detailed explanation.
Fig. 1 is the sketch map of one of them embodiment of the laser light-source device of coherent Raman scattering microscopic system of the present invention.
Please referring to Fig. 1, the present embodiment device comprises ultrashort pulse fiber laser 1-1, is used to produce the required stokes light of coherent Raman scattering process, and the pump light of parametric amplifier.
Beam splitter 2 is used for carrying out beam splitting according to the output light of certain power comparison ultrashort pulse fiber laser 1-1, produces described stokes light and pump light.
Optical delay line 3 is used for adjustment or compensation optical path difference.Polarizer 18 is used to adjust polarization state.
The first light beam bundling device 10 and the second light beam bundling device 5 are used for the light of two bundle different wave lengths is closed bundle in the space;
Tunable continuous light semiconductor laser 1-2 is used to obtain the seed light of parametric amplifier.Fiber amplifier 1-3 is used for the output of tunable continuous light semiconductor laser 1-2 is amplified, and the light after the amplification is called the seed light of parametric amplifier.
First nonlinear crystal 12, second nonlinear crystal 16 are respectively applied for and carry out that parameter amplifies, frequency multiplication.
When forming concrete light path, the device of present embodiment also comprises following device:
Band pass filter 13 will be leached by the pulse of the new Wavelength-converting of parametric amplifier gained.
The 1/1st wave plate 1 (wherein first and second of this specification just to the identical device of differentiation title, but not representes ordinal number), the 1/2nd wave plate 8 are used to adjust polarization state.
Dichroic mirror 17 is used for filtering.
First lens 6, second lens 9 and condenser lens 14 are used for light beam is focused on.
Optical fiber collimator 7 is used for output with the erbium-doped fiber amplifier 1-3 output that collimates.
Speculum 4 is used for reflected light path.
First temperature controlling stove 11 and second temperature controlling stove 15 are used to adjust and keep first nonlinear crystal 12 and second nonlinear crystal 16 in appropriate working temperature.
Example below in conjunction with concrete describes.
Said ultrashort pulse fiber laser 1-1 is ultrashort pulse ytterbium-doping optical fiber laser (also can be the ultrashort pulse neodymium-doped fiber laser) in the present embodiment, can obtain the output light of centre wavelength 1040nm, full width at half maximum～3ps, pulse energy 10nJ.It is carried out beam splitting through beam splitter 2 (splitting ratio 1: 3), and wherein pulse energy is the pump light of the part of 7.5nJ as parametric amplifier, and the part that another energy is 2.5nJ is as the required stokes light of coherent Raman scattering process.Ultrashort pulse fiber laser 1-1 can also be the picosecond laser of femto-second laser or other wave band.Need to prove that beam splitter 2 also can have other splitting ratio, be not limited to 1: 3.Can select the beam splitter of any splitting ratio according to actual needs.
Tunable continuous light semiconductor laser 1-2 is Agilent (Aglient) company, model 8164A, the laser of output wavelength 1510-1640nm.Fiber amplifier 1-3 is an erbium-doped fiber amplifier, is exported by optical fiber collimator 7 collimations through the light of its amplification, as the seed light of follow-up parametric amplifier.
The 1/1st wave plate 1 is adjusted above-mentioned pump light respectively with the 1/2nd wave plate 8 and is made that with the seed polarization state of light its polarization state is parallel; And adopt first lens 6 and second lens 9 to focus on; Close bundle to the first nonlinear crystal 12 through the first light beam bundling device 10 then, this first nonlinear crystal 12 is as parametric amplifier.What wherein, said first nonlinear crystal 12 can be in three lithium borate lbo crystals, periodic polarized lithium niobate PPLN crystal, period polarized doped with magnesia lithium niobate MgO:PPLN crystal, the period polarized superlattice lithium tantalate PPLST crystal is a kind of.Be specially multipolarization cycle MgO:PPLN crystal (its polarization cycle comprises 29.6um, 30um and 30.4um) in the present embodiment, select the waveguide of required polarization cycle and adjust first temperature controlling stove 11 to the proper temperature and carry out parameter and amplify (the thermal tuning curve of parametric amplifier MgO:PPLN is as shown in Figure 2 under the different polarization cycles).
To be leached by the 1510-1640nm output pulse of parametric amplifier gained through band pass filter 13, and adopt convergent lens 14 to focus to second nonlinear crystal 16, said second nonlinear crystal 16 is as frequency multiplier.Said second nonlinear crystal 16 can be in three lithium borate lbo crystals, periodic polarized lithium niobate PPLN crystal, period polarized doped with magnesia lithium niobate MgO:PPLN crystal, the period polarized superlattice lithium tantalate PPLST crystal a kind of.Be specially multipolarization cycle MgO:PPLN crystal (polarization cycle comprises 18.2um, 18.8um, 19.4um, 20.0um, 20.6um and 21.2um) in the present embodiment, select the waveguide of required polarization cycle and adjust second temperature controlling stove 15 to appropriate temperature and carry out frequency multiplication (the thermal tuning curve of frequency-doubling crystal MgO:PPLN is as shown in Figure 3 under the different polarization cycles).
To leach by dichroic mirror 17 by the pulsed light of the 755-820nm of gained after the frequency multiplier frequency multiplication.Light path through optical delay line 3 adjustment stokes lights overlaps above-mentioned two beam pulses in time.Adjust the polarizer 18 (polarizer is 1/2nd wave plates in the present embodiment) on the Stokes light path simultaneously, make that the polarization state of two beam pulses is parallel.And adopt the second light beam bundling device 5 to make light that dichroic mirror 17 leaches and stokes light at space coincidence.Promptly can be used as the micro-LASER Light Source of coherent Raman scattering after the coupling of two beam pulses, for example be coupled to microscope 1-5 and can carry out the CARS micro-imaging.
For the SRS micro-imaging, also need adopt acousto-optic modulator 19 (or electrooptic modulator) that stokes light is carried out intensity modulated, so that carry out coherent detection.Acousto-optic modulator 19 is controlled via the signal processing unit 1-7 and the signal generator that are connected with computer 1-6.Here be not described in detail.
The output wavelength of tuning tunable continuous light semiconductor laser (scope 1510 is to 1640nm), said apparatus can be to raman characteristic peak at 2579cm
-1To 3846cm
-1The sample of scope carries out the coherent Raman scattering micro-imaging.
Illustrate, (wherein the characteristic peak of CH2 key is at 2845cm like content of oil and grease in the desire testing biological specimen
-1Near), can the output wavelength of tunable continuous light semiconductor laser be arranged on 1605nm.With reference to Fig. 2, can select that polarization cycle is the waveguide of 30.4um in the MgO:PPLN crystal 12 for use, and 120 ℃ of its temperature are set, parametric amplifier can consume the energy of 1040nm pulse and obtain the 1605nm pulse this moment.With reference to figure 3, select that polarization cycle is the waveguide of 20.6um in the MgO:PPLN crystal 16 for use, and its temperature is set is 102.8 ℃, 1605nm pulse generation this moment frequency multiplication obtains the 802.5nm pulse.The part 1040nm pulse of beam splitting gained is overlapped on time, space with the new 802.5nm pulse that produces, just can be used for the CARS micro-imaging of grease.
It is thus clear that the device of the above embodiment of the present invention because pulse pump light carries out the parameter amplification to continuous seed light in the parametric amplifier, can obtain lock-out pulse in the seed light wavelength, so need not to consider the stationary problem between the two-beam automatically.And, can obtain high parameter transformation efficiency because seed light has the high power spectrum density continuously.
The device of the above embodiment of the present invention, adopting tunable continuous light semiconductor laser is that parametric amplifier provides seed light, can obtain lock-out pulse dexterously, has improved the transformation efficiency of parametric process simultaneously, has reduced system cost and complexity; Adopt ultrashort pulse fiber laser to produce the required stokes light of coherent Raman scattering and the pump light of parametric amplifier, system configuration is compact, with low cost.
Though the present invention with preferred embodiment openly as above; But it is not to be used for limiting the present invention; Any those skilled in the art are not breaking away from the spirit and scope of the present invention; Can make possible change and modification, so protection scope of the present invention should be as the criterion with the scope that claim of the present invention was defined.
Claims (12)
1. the laser light-source device of a coherent Raman scattering microscopic system is characterized in that comprising:
Ultrashort pulse fiber laser and to the beam splitter of the output light beam splitting of ultrashort pulse fiber laser, the two-beam after the beam splitting is respectively as the stokes light of coherent Raman scattering process and the pump light of parametric amplifier;
Tunable continuous light semiconductor laser and the fiber amplifier that the output light of tunable continuous light semiconductor laser is amplified, the light after the amplification is called the seed light of parametric amplifier;
The seed light of said pump light and parametric amplifier is closed the first light beam bundling device of bundle in the space;
Receive first nonlinear crystal and second nonlinear crystal of the first light beam bundling device light beam in order, two nonlinear crystals are respectively as parametric amplifier and frequency multiplier;
The output light of said stokes light and frequency multiplier is closed the second light beam bundling device of bundle in the space;
The polarizer that the optical delay line that is arranged in the light path of stokes light and before the second light beam bundling device closes bundle, stokes light is carried out the light path adjustment respectively and polarization state are adjusted.
2. the laser light-source device of coherent Raman scattering microscopic system as claimed in claim 1 is characterized in that: said ultrashort pulse fiber laser is femtosecond pulse fiber laser or Picopulse optical fiber laser.
3. the laser light-source device of coherent Raman scattering microscopic system as claimed in claim 1 is characterized in that: said ultrashort pulse fiber laser is ultrashort pulse ytterbium-doping optical fiber laser or ultrashort pulse neodymium-doped fiber laser.
4. the laser light-source device of coherent Raman scattering microscopic system as claimed in claim 1; It is characterized in that: said beam splitter energy splitting ratio 1: 3; Wherein the light beam of 1/4th energy is as the stokes light of coherent Raman scattering process, and the light beam of 3/4ths energy is as the pump light of parametric amplifier.
5. the laser light-source device of coherent Raman scattering microscopic system as claimed in claim 1 is characterized in that: said tunable continuous light semiconductor laser output wavelength scope is 1510nm to 1640nm.
6. the laser light-source device of coherent Raman scattering microscopic system as claimed in claim 5 is characterized in that: said fiber amplifier is an erbium-doped fiber amplifier.
7. the laser light-source device of coherent Raman scattering microscopic system according to claim 6; It is characterized in that: also comprise the 1/1st wave plate and the 1/2nd wave plate; First condenser lens and second condenser lens; Said seed light is parallel through 1/2nd wave plate adjustment polarization state respectively with the pumping combiner before, and focuses on through two condenser lenses.
8. the laser light-source device of coherent Raman scattering microscopic system as claimed in claim 1 is characterized in that: said first nonlinear crystal is a kind of in lithium triborate crystal, periodic polarized lithium columbate crystal, period polarized magnesium oxide doped lithium niobate crystal, the period polarized superlattice lithium tantalate;
Said second nonlinear crystal is a kind of in lithium triborate crystal, periodic polarized lithium columbate crystal, period polarized magnesium oxide doped lithium niobate crystal, the period polarized superlattice lithium tantalate.
9. the laser light-source device of coherent Raman scattering microscopic system according to claim 8 is characterized in that: said first nonlinear crystal and second nonlinear crystal all are arranged in the temperature controlling stove.
10. the laser light-source device of coherent Raman scattering microscopic system according to claim 1 is characterized in that: between said first nonlinear crystal and second nonlinear crystal, set gradually band pass filter and the 3rd condenser lens; Between said second nonlinear crystal and the second light beam bundling device, be provided with dichroic mirror; Wherein,
Said band pass filter is used to leach the pulsed light of the new Wavelength-converting of parametric amplifier gained, is projected to the 3rd condenser lens;
The pulsed light that said dichroic mirror is used for after the frequency multiplier frequency multiplication leaches, and is projected to the second light beam bundling device.
11. the laser light-source device of coherent Raman scattering microscopic system according to claim 1 is characterized in that: said polarizer is 1/2nd wave plates, is used to adjust the output light that the Stokes polarization state of light is parallel to second nonlinear crystal.
12. the production method of the LASER Light Source of a coherent Raman scattering microscopic system is characterized in that comprising:
The output light of ultrashort pulse fiber laser is carried out beam splitting, and wherein a part is used to the stokes light that provides the coherent Raman scattering process required, and another part is as the pump light of parametric amplifier;
The output light of tunable continuous light semiconductor laser is amplified through fiber amplifier, and itself and pump light through the parametric amplifier of beam splitting are together focused to first nonlinear crystal carry out parameter and amplify;
To leach by the output pulse that parameter amplify the back gained, and focus to second nonlinear crystal and carry out frequency multiplication;
To leach by the pulsed light of frequency multiplication gained;
The light path and the polarization state of adjustment stokes light overlap the light pulse after said stokes light and the frequency multiplication in time, and polarization state parallels; And make the two at space coincidence.Can obtain the LASER Light Source of coherent Raman scattering microscopic system thus.
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| CN108240979A (en) * | 2016-12-27 | 2018-07-03 | 深圳大学 | Coherent anti-stokes raman scattering micro imaging system and imaging method |
| CN108240979B (en) * | 2016-12-27 | 2023-10-27 | 深圳大学 | Coherent anti-stokes raman scattering microscopic imaging system and imaging method |
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| CN107991270B (en) * | 2017-12-28 | 2023-10-20 | 中国科学院苏州生物医学工程技术研究所 | Blood species identification system based on coherent anti-Stokes Raman spectrum |
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| CN108963748A (en) * | 2018-06-13 | 2018-12-07 | 上海理工大学 | Multi-functional coherent Raman scattering bio-imaging light source |
| CN108963748B (en) * | 2018-06-13 | 2020-07-17 | 上海理工大学 | Multifunctional coherent Raman scattering biological imaging light source |
| CN108964781A (en) * | 2018-08-13 | 2018-12-07 | 广州光智科技有限公司 | Multichannel coherent Raman scattering Optical devices and imaging system |
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