CN102626097A - Bactericidal composition containing famoxadone - Google Patents
Bactericidal composition containing famoxadone Download PDFInfo
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- CN102626097A CN102626097A CN2012100845102A CN201210084510A CN102626097A CN 102626097 A CN102626097 A CN 102626097A CN 2012100845102 A CN2012100845102 A CN 2012100845102A CN 201210084510 A CN201210084510 A CN 201210084510A CN 102626097 A CN102626097 A CN 102626097A
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Abstract
The invention discloses an agricultural bactericidal composition which contains famoxadone and fungicides preventing and treating oomycetes. The bactericidal composition comprises an effective active ingredient composed of first active ingredient famoxadone and second active ingredient fungicides preventing and treating oomycetes, selected from one of fluopicolide and iprovalicarb; and the weight ratio of the first active ingredient to the second active ingredient is 1:5-15:1. The composition can be prepared into a water dispersible granule, wettable powder, a suspending agent and a flowable concentrate for seed coating allowed in agriculture. The bactericidal composition has the beneficial effects that components are reasonable, the sterilizing effect is good, the pesticide use cost is low, and the activity and the sterilizing effect of the bactericidal composition are not simply superposed by the activities of all the components; and compared with the present single preparation, the bactericidal composition not only has remarkable sterilizing effect, but also has remarkable synergistic effect, has no pollution to crops, is good in safety and conforms to the safety requirements of pesticide preparations. The bactericidal composition has remarkable prevention and treatment effect on crop downy mildew, epidemic diseases, cataplexy diseases and downy blight.
Description
Technical field
The present invention relates to a kind of bactericidal composition, particularly Yi Zhong oxazole bacterium ketone and fluorine pyrrole bacterium amine or the composite bactericidal composition of iprovalicarb belong to technical field of compounded pesticide.
Background technology
The English common name famoxadone of oxazole bacterium ketone, molecular formula C
22H
18N
2O
4, chemical name: 3-anilino--5-methyl-5-(4-Phenoxyphenyl)-1,3-azoles quinoline-2,4-diketone.It is a kind of new and effective, wide-spectrum bactericide; Its mechanism of action is the mitochondria electron transfer inhibitor; Have protection, treat, root out, infiltration, systemic activity; There is not cross resistance with the phenyl amide series bactericidal agent, suitable crop such as wheat, barley, pea, beet, rape, grape, potato, melon, capsicum, tomato, fruit tree etc.Be mainly used in the important disease of preventing and treating in Ascomycetes, Basidiomycetes, the Oomycete such as powdery mildew, rust, glume blight, net blotch, downy mildew, late blight etc.Have lipophilicity, spray easy adhesion the on the crop leaf, resistance of rainwater washing against, but its use cost is high, uses separately to be difficult to the large tracts of land popularization.
Oomycete belongs to Mycophyta, is the Mastigomycotina guiding principle, and Oomycete mainly contains pythium spp, phytophthora, downy mildew etc., often causes downy mildew, eqpidemic disease, damping off of crop etc.Prevent and treat this type disease medicament commonly used dimethomorph, metalaxyl, Propamocarb, phosethyl-Al, fluorine pyrrole bacterium amine, iprovalicarb etc. and mixture thereof are arranged.
Fluorine pyrrole bacterium amine, English common name fluopicolide, chemical name: 2,6-two chloro-N (3-chloro-5-trifluoromethyl-2-pyridine radicals) methyl) benzamide.Fluorine pyrrole bacterium amine is botanical fungicide, and protectiveness is good, permeability is strong, and the Oomycete disease is had higher biologically active, has good control efficiency.Can conduct from leaves of plants basal orientation blade tip direction.To crop and Environmental security, be specially adapted to high-quality, green vegetables production.
Iprovalicarb; English common name Iprovalicarb; Chemical name: [two-methyl isophthalic acid-(4-tolyl) ethylamino formoxyl]-propyl group]-carbamic acid isopropyl ester; Iprovalicarb is the amino-acid ester analog derivative, has unique brand-new biomimetic features, makes its mechanism of action be different from the bactericide that other prevent and treat Oomycete.Its mechanism of action is act on fungal cell wall and protein synthetic, can suppress infecting and sprouting of spore, can suppress mycelial growth simultaneously, causes its distortion, death.Have good treatment and eradicant action to Peronosporaceae and the fungus-caused disease of Phytophthora.
The inventor finds through test; The different De oxazole of mechanism of action bacterium ketone and fluorine pyrrole bacterium amine or iprovalicarb is composite, have obvious synergistic effect, can significantly improve treatment, protection control efficiency, reduce spraying times and dosage; Reduce the control cost, to crop safety.
Summary of the invention
The object of the present invention is to provide a kind of component reasonable, synergistic effect is remarkable, and bactericidal effect is good, and drug cost is low, is difficult for developing immunity to drugs, to the agricultural bactericidal composition of crop safety.
Another object of the present invention is to provide the application of above-mentioned composition on control crops downy mildew, eqpidemic disease, damping off, peronospora tabacina.
In order to overcome the defective of existing single preparation, technical scheme of the present invention is to solve like this:
A) a property one-tenth alive divides oxazole bacterium ketone;
B) second active component fluorine pyrrole bacterium amine or the iprovalicarb;
The weight ratio of first active component and second active component is 1:5～15:1, be preferably? 1:2～2:1.
The cumulant of first active component and second active component (weight sum) is 5%～90% of a said composition total weight, is preferably 10%～70%.
The preparation formulation that the bactericidal composition of oxazole bacterium ketone of the present invention and fluorine pyrrole bacterium amine or iprovalicarb can be prepared according to method known in those skilled in the art is water dispersible granules, wetting powder, suspending agent, suspension seed-coating agent.
For water dispersible granules, those skilled in the art are familiar with the use corresponding adjuvants and accomplish the present invention very much.In dispersant such as polycarboxylate, lignosulfonates, the alkylnaphthalene sulfonate one or more; In wetting agent such as alkyl sulfate, alkylsulfonate, the naphthalene sulfonate one or more; In disintegrant such as ammonium sulfate, urea, sucrose, the glucose one or more; In binding agent such as diatomite, corn starch, PVA, carboxymethyl (ethyl) cellulose family one or more; Filler such as diatomite, kaolin, white carbon, fine particle calcium carbonate, talcum powder, attapulgite, potter's clay one or more.
To wetting powder, spendable auxiliary agent has: in dispersant such as polycarboxylate, lignosulfonates, the alkylnaphthalene sulfonate one or more; In wetting agent such as alkyl sulfate, alkylsulfonate, the naphthalene sulfonate one or more; Filler such as ammonium sulfate, urea, sucrose, glucose, diatomite, kaolin, white carbon, fine particle calcium carbonate, talcum powder, attapulgite, potter's clay one or more.
To suspending agent, spendable auxiliary agent has: among dispersant such as polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate (dispersing agent NNO), the TERSPERSE 2020 (U.S. Huntsman Corporation produces, the alkyl naphthalene sulfonic acid salt) one or more; Alkyl phenol formaldehyde resin polyoxyethylene ether), farming breast 2201, this dish-60# (common name: Span60), Tween-60 # (common name: the polyoxyethylene sorbitan stearate), agricultural newborn 1601# (common name: triphen ethyl-phenol polyoxyethylene polyoxypropylene block polymer), among the TERSPERSE 4894 (U.S. Huntsman Corporation product) one or more emulsifier such as Nongru-700 # (common name:; Among wetting agent such as alkylphenol-polyethenoxy base ether formaldehyde condensation products sulphate, alkylphenol-polyethenoxy base ether phosphate, phenethyl phenol polyethenoxy base ether phosphate, alkyl sulfate, alkylsulfonate, naphthalene sulfonate, the TERSPERSE 2500 (U.S. Huntsman Corporation product) one or more; In thickener such as xanthans, polyvinyl alcohol, bentonite, the aluminium-magnesium silicate one or more; In preservative such as formaldehyde, benzoic acid, the Sodium Benzoate one or more; In stabilizing agent such as epoxidized soybean oil, epoxychloropropane, the triphenyl phosphate one or more; Antifoaming agent such as organic silicon defoamer; In antifreezing agent such as ethylene glycol, propane diols, glycerine, urea, inorganic salts such as the sodium chloride one or more; Water is deionized water.
To suspension seed-coating agent; Spendable auxiliary agent has: binding agent such as polysaccharose macromolecular compound (soluble starch, polypropylene graft copolymer, xanthan gum, microorganism mucilage), cellulose derivatives (hydroxypropyl methylcellulose, sodium carboxymethylcellulose, ethyl cellulose), seaweeds such as sodium alginate, agar; Rosin, paraffin, gelatin, pectin; The water-soluble composite of polyvinyl alcohol, polyethylene glycol, polyvinyl acetate, polyacrylamide, polyvinylpyrrolidone and polyhydric alcohol polymer, in the inorganic binder (aluminium-magnesium silicate, clay, waterglass, gypsum) one or more; Among dispersant such as polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate, the TERSPERSE 2020 (U.S. Huntsman Corporation produces, the alkyl naphthalene sulfonic acid salt) one or more; Alkyl phenol formaldehyde resin polyoxyethylene ether), farming breast 2201, this dish-60# (common name: sorbitan monostearate), emulsifier T-60 (common name: the sorbitan monostearate APEO), agricultural newborn 1601# (common name: phenethyl phenol polyoxyethylene poly-oxygen propylene aether), among the TERSPERSE 4894 (U.S. Huntsman Corporation product) one or more emulsifier such as Nongru-700 # (common name:; Among wetting agent such as alkylphenol-polyethenoxy base ether formaldehyde condensation products sulphate, alkylphenol-polyethenoxy base ether phosphate, phenethyl phenol polyethenoxy base ether phosphate, alkyl sulfate, alkylsulfonate, naphthalene sulfonate, the TERSPERSE 2500 (U.S. Huntsman Corporation product) one or more; In thickener such as xanthans, polyvinyl alcohol, the bentonite one or more; In preservative such as formaldehyde, benzoic acid, the Sodium Benzoate one or more; Antifoaming agent such as organic silicon defoamer; In antifreezing agent such as ethylene glycol, propane diols, glycerine, urea, inorganic salts such as the sodium chloride one or more; Water is deionized water.
Component of the present invention is reasonable, and treatment adds protective effect, and bactericidal effect is good, and drug cost is low, and its active and bactericidal effect is not the simple superposition of each composition activity, but significant synergistic effect is arranged, and is good to crop safety, meets the security requirement of pesticidal preparations.The present invention has the better prevention effect to control crops downy mildew, eqpidemic disease, damping off, peronospora tabacina.
Embodiment
In order to prevent and treat vegetables, the fruit tree downy mildew in the agricultural production, inventor Yi oxazole bacterium ketone and fluorine pyrrole bacterium amine or iprovalicarb have carried out mutual composite synergy research, and concrete grammar is:
It is tested object that bacterium of downy mildew of cucumber (Pseudoperonospora cubensis) is adopted in test.Test used former medicine by the preparation of technology department of Shanggezhilu Biosciences Co., Ltd., Shaanxi, and former medicine is mixed with the test medicine that needs, test method is with reference to " the agricultural industry criteria NY/T1156.3-2006 of the People's Republic of China (PRC) ".At first single agent and each Mixed Pharmacy being provided with 5 variable concentrations gradient oxazole bacterium ketone concentration is 4 mg/L, 8 mg/L, 16 mg/L, 32 mg/L, 64 mg/L, and fluorine pyrrole bacterium amine, iprovalicarb and each mixture concentration are 2 mg/L, 4 mg/L, 8 mg/L, 16 mg/L, 32 mg/L.Test target bacterium is to pick up from the field bacterium of downy mildew of cucumber blade of 4 leaves～6 leaf positions from up to down; Wash the Pseudoperonospora cubensis sporangium of vacuum side of blade with 4 ℃ of distilled water; Be made into suspension (concentration is controlled at every milliliter of 1 * 105～1 * 107 sporangium), deposit under 4 ℃ subsequent use; Soup is evenly sprayed in the healthy leaves back side, treat the soup natural air drying after, each is handled blade and blade goes up dorsad, by being emitted on behind the marks for treatment in the box of preserving moisture.Test is established the processing that does not contain medicament and is made blank.Be inoculated in vacuum side of blade with ready fresh sporangia suspension drop 10 μ L.4 of every blade inoculations, every processing are no less than 5 leaves.The protectiveness test is the 24h inoculation after chemicals treatment, and the therapeutic test is the 24h inoculation before processing.Ware lid on the inoculation bonnet places climatic cabinate or the humidistat of illumination is arranged, the continuous illumination in every day/dark 12h alternately, temperature is 17 ℃～22 ℃, cultivates under the condition of relative moisture more than 90%.Look and handle and measurement of blank incidence and record scab diameter, unit is a millimeter (mm), calculates control efficiency.The EC of each medicament is obtained in linear regression analysis between the probit value through control efficiency and the logarithm value of series concentration
50Value with the co-toxicity coefficient (CTC) of the abundant method calculating of Sun Yun mixture, is estimated the activity of confession reagent agent to germ with this.
The co-toxicity coefficient of mixture (CTC value) calculates by following formula:
In the formula:
ATI-----mixture actual measurement toxicity index;
S---standard bactericide LC
50, unit is every liter (mg/L) of milligram;
The LC of M---mixture
50, unit is every liter (mg/L) of milligram;
TTI=TI
A×P
A+?TI
B×P
B
In the formula:
The theoretical toxicity index of TTI---mixture;
TI
A---A medicament toxicity index;
P
A---the percentage composition of A medicament in mixture, unit are percentage (%);
TI
B---B medicament toxicity index;
P
B---the percentage composition of B medicament in mixture, unit are percentage (%);
In the formula:
CTC---co-toxicity coefficient;
ATI---mixture actual measurement toxicity index;
The theoretical toxicity index of TTI---mixture;
The co-toxicity coefficient of complex preparation (CTC)>=120 shows as synergistic effect; CTC≤80 show as antagonism; 80＜CTC＜120 show as summation action.
Toxicity Determination result shows that: oxazole bacterium ketone and fluorine pyrrole bacterium amine or iprovalicarb are that 1:5～15:1 uses with bacterium of downy mildew of cucumber is had virulence preferably with the weight ratio, all have significant synergistic effect.
Be the eqpidemic disease in the control agricultural production, inventor Yi oxazole bacterium ketone and fluorine pyrrole bacterium amine or iprovalicarb carry out composite each other synergy research, and concrete grammar is:
Subjects is tomato early blight bacterium (Alternaria solani).Test used former medicine by the preparation of technology department of Shanggezhilu Biosciences Co., Ltd., Shaanxi, and former medicine is mixed with the test medicine that needs, test method is with reference to " the agricultural industry criteria NY/T1156.2-2006 of the People's Republic of China (PRC) ".At first single agent and each Mixed Pharmacy being provided with 5 variable concentrations gradient oxazole bacterium ketone concentration is 4 mg/L, 8 mg/L, 16 mg/L, 32 mg/L, 64 mg/L, and fluorine pyrrole bacterium amine, iprovalicarb and each mixture concentration are 1 mg/L, 2 mg/L, 4 mg/L, 8 mg/L, 16 mg/L.If the clear water contrast repeats 3 times.Adopt the mycelial growth rate method, with cultured pathogen, under aseptic condition, using diameter is 5 mm card punch, cuts the bacterium cake from colony edge, with transfer needle the bacterium cake is connected on the culture medium flat plate of different drug concentrations, puts in 26 ℃ of incubators and cultivates 72h; The inspection colony diameter calculates the percentage that each chemicals treatment suppresses mycelial growth, and the EC of each medicament is obtained in the linear regression analysis between the probit value through inhibiting rate and the logarithm value of series concentration
50Value, with the co-toxicity coefficient (CTC) of the abundant method calculating of Sun Yun mixture, computing formula is estimated the activity of confession reagent agent to germ with the downy mildew toxicity test with this.
The co-toxicity coefficient of complex preparation (CTC)>=120 shows as synergistic effect; CTC≤80 show as antagonism; 80＜CTC＜120 show as summation action.
Toxicity Determination result shows: oxazole bacterium ketone and fluorine pyrrole bacterium amine (or iprovalicarb), is that 1:5～15:1 uses with early blight of tomato is had virulence preferably with the weight ratio, and significant synergistic effect is all arranged.
Below in conjunction with embodiment the present invention is described further:
FORMULATION EXAMPLE 1
Take by weighing 28% oxazole bacterium ketone, 14% fluorine pyrrole bacterium amine, 4% Morwet D-425 (alkyl naphthalene sulfonic acid condensation polymer sodium salt, Akzo Nobel N.V. produces), 3% dispersing agent NNO (alkylnaphthalene sulfonate formaldehyde condensation products), 2% Nekal BX (nekal), 2%K-12 (lauryl sodium sulfate), 3% corn starch, 5% sucrose, kaolin adds to 100% weight portion.The method of the frequent regulation of above-mentioned raw materials water intaking dispersible granule is promptly mixed, ultra micro comminution by gas stream, mixing, granulation step are produced 42% oxazole bacterium ketone fluorine pyrrole bacterium amine water dispersible granules.
FORMULATION EXAMPLE 2
Take by weighing 55% oxazole bacterium ketone, 35% fluorine pyrrole bacterium amine, 1% TERSPERSE 2700 (polycarboxylate, U.S. Huntsman Corporation produces), 1% dispersing agent NNO (alkylnaphthalene sulfonate formaldehyde condensation products), 1% Nekal BX (nekal), 1%K-12 (lauryl sodium sulfate), 1% carboxymethyl cellulose, diatomite adds to 100% weight portion.The method of the frequent regulation of above-mentioned raw materials water intaking dispersible granule is promptly mixed, ultra micro comminution by gas stream, mixing, granulation step are produced 90% oxazole bacterium ketone fluorine pyrrole bacterium amine water dispersible granules.
FORMULATION EXAMPLE 3
Take by weighing 48% oxazole bacterium ketone, 12% iprovalicarb, 4% TERSPERSE 2700 (polycarboxylate, U.S. Huntsman Corporation produces), 2% dispersing agent NNO (alkylnaphthalene sulfonate formaldehyde condensation products), 2% Nekal BX (nekal), 2%K-12 (lauryl sodium sulfate), 3% corn starch, 5% sulphur ammonium, attapulgite adds to 100% weight portion.The method of the frequent regulation of above-mentioned raw materials water intaking dispersible granule is promptly mixed, ultra micro comminution by gas stream, mixing, granulation step are produced 60% oxazole bacterium ketone iprovalicarb water dispersible granules.
FORMULATION EXAMPLE 4
Take by weighing 20% oxazole bacterium ketone, 20% iprovalicarb, 3% TERSPERSE 2700 (polycarboxylate, U.S. Huntsman Corporation produces), 3% dispersing agent NNO (alkylnaphthalene sulfonate formaldehyde condensation products), 2% Nekal BX (nekal), 2%K-12 (lauryl sodium sulfate), 1% carboxymethyl cellulose, 5% urea, diatomite adds to 100% weight portion.The method of the frequent regulation of above-mentioned raw materials water intaking dispersible granule is promptly mixed, ultra micro comminution by gas stream, mixing, granulation step are produced 40% oxazole bacterium ketone iprovalicarb water dispersible granules.
FORMULATION EXAMPLE 5
Take by weighing 10% oxazole bacterium ketone, 50% fluorine pyrrole bacterium amine, 5% calcium lignosulfonate, 2% Nekal BX (nekal), 2%K-12 (lauryl sodium sulfate), 5% white carbon black, kaolin and add to 100% weight portion.Above-mentioned raw materials makes 60% oxazole bacterium ketone fluorine pyrrole bacterium amine wetting powder through mixing behind the comminution by gas stream.
FORMULATION EXAMPLE 6
Take by weighing 45% oxazole bacterium ketone, 3% fluorine pyrrole bacterium amine, 4% calcium lignosulfonate, 3% TERSPERSE 2700 (polycarboxylate, U.S. Huntsman Corporation produces), 2% Nekal BX (nekal), 2%K-12 (lauryl sodium sulfate), 3% white carbon black, fine particle calcium carbonate adds to 100% weight portion.Above-mentioned raw materials makes 48% oxazole bacterium ketone fluorine pyrrole bacterium amine wetting powder through mixing behind the comminution by gas stream.
FORMULATION EXAMPLE 7
Take by weighing 49% oxazole bacterium ketone, 7% iprovalicarb, 4% calcium lignosulfonate, 4% dispersing agent NNO (alkylnaphthalene sulfonate formaldehyde condensation products), 2% Nekal BX (nekal), 2%K-12 (lauryl sodium sulfate), 3% white carbon black, attapulgite and add to 100% weight portion.Above-mentioned raw materials makes 56% oxazole bacterium ketone iprovalicarb wetting powder through mixing behind the comminution by gas stream.
FORMULATION EXAMPLE 8
Take by weighing 40% oxazole bacterium ketone, 8% iprovalicarb, 4% calcium lignosulfonate, 3% TERSPERSE 2700 (polycarboxylate, U.S. Huntsman Corporation produces), 2% Nekal BX (nekal), 2%K-12 (lauryl sodium sulfate), 3% white carbon black, fine particle calcium carbonate adds to 100% weight portion.Above-mentioned raw materials makes 48% oxazole bacterium ketone iprovalicarb wetting powder through mixing behind the comminution by gas stream.
FORMULATION EXAMPLE 9
Take by weighing 10% oxazole bacterium ketone, 20% fluorine pyrrole bacterium amine, 4%TERSPERSE 4894 (U.S. Huntsman Corporation product), 1.5%TERSPERSE 2500 (U.S. Huntsman Corporation product), 2%TERSPERSE 2020 (U.S. Huntsman Corporation product), 1% aluminium-magnesium silicate, 0.2% xanthans, 5% ethylene glycol, 0.5% formaldehyde, 0.5% silicone defoaming agent (trade name: s-29 Nanjing "four news" (new ideas applied chemistry article company produces), 2% triphenyl phosphate, deionized water adds to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making 30% oxazole bacterium ketone fluorine pyrrole bacterium amine suspending agent behind the sand mill sand milling.
FORMULATION EXAMPLE 10
Take by weighing 42% oxazole bacterium ketone, 7% fluorine pyrrole bacterium amine, 5%TERSPERSE 4894 (U.S. Huntsman Corporation product), 2%TERSPERSE 2500 (U.S. Huntsman Corporation product), 3%TERSPERSE 2020 (U.S. Huntsman Corporation product), 0.2% xanthans, 5% propane diols, 0.5% benzoic acid, 1% epoxychloropropane, 0.5% silicone defoaming agent (trade name: s-29 Nanjing "four news" (new ideas applied chemistry article company produces), 1% epoxychloropropane, deionized water adds to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making 49% oxazole bacterium ketone fluorine pyrrole bacterium amine suspending agent behind the sand mill sand milling.
FORMULATION EXAMPLE 11
Take by weighing 7% oxazole bacterium ketone, 3% iprovalicarb, 2%TERSPERSE 2020 (U.S. Huntsman Corporation product), 2% this dish-60#, 2% Tween-60 #, 1%TERSPERSE 2500 (U.S. Huntsman Corporation product), 0.5% white carbon, 0.3% xanthans, 5% ethylene glycol, 0.5% benzoic acid, 0.5% silicone defoaming agent (trade name: s-29 Nanjing "four news" (new ideas applied chemistry article company produces), 1% epoxychloropropane, deionized water adds to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making 10% oxazole bacterium ketone iprovalicarb suspending agent behind the sand mill sand milling.
FORMULATION EXAMPLE 12
Take by weighing 33% oxazole bacterium ketone, 11% iprovalicarb, 1%TERSPERSE 2020 (U.S. Huntsman Corporation product), 3% agricultural newborn 1601#, 2% agricultural newborn 2201#, 1%TERSPERSE 2500 (U.S. Huntsman Corporation product), 0.3% xanthans, 5% ethylene glycol, 0.5% formaldehyde, 0.5% silicone defoaming agent (trade name: s-29 Nanjing "four news" (new ideas applied chemistry article company produces), 1% epoxychloropropane, deionized water adds to 100% weight portion.High speed shear is disperseed 30min, with making 44% oxazole bacterium ketone iprovalicarb suspending agent behind the sand mill sand milling.
Embodiment 13
Take by weighing 24% oxazole bacterium ketone, 8% fluorine pyrrole bacterium amine, 1%TERSPERSE 2700 (polycarboxylate, U.S. Huntsman Corporation produces), 1%TERSPERSE 2500 (U.S. Huntsman Corporation products), 3% TERSPERSE 4894 (U.S. Huntsman Corporation product), 2.0% polyvinylpyrrolidone, 0.2% xanthans, 5% ethylene glycol, 0.3% benzoic acid, (trade name: s-29 Nanjing "four news" (new ideas applied chemistry article company product) deionized water adds to 100% weight portion to 0.5% silicone defoaming agent.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making 32% oxazole bacterium ketone fluorine pyrrole bacterium amine suspension seed-coating agent behind the sand mill sand milling.
Embodiment 14
Take by weighing 14% oxazole bacterium ketone, 7% iprovalicarb, 3%TERSPERSE 4894 (U.S. Huntsman Corporation product), 2%TERSPERSE 2500 (U.S. Huntsman Corporation product), 1%TERSPERSE 2020 (U.S. Huntsman Corporation product), 1.0% hydroxypropyl methylcellulose, 0.5% bentonite, 5% ethylene glycol, 0.3% Sodium Benzoate, 0.5% silicone defoaming agent (trade name: s-29 Nanjing "four news" (new ideas applied chemistry article company produces) deionized water and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making 21% oxazole bacterium ketone iprovalicarb suspension seed-coating agent behind the sand mill sand milling.
Biological Examples 1: control cotton in seedling stage damping off field trial
2011 in Shaanxi Province Weinan City carried out FORMULATION EXAMPLE 13 (32% oxazole bacterium ketone fluorine pyrrole bacterium amine suspension seed-coating agent), FORMULATION EXAMPLE 14 (21% oxazole bacterium ketone iprovalicarb suspension seed-coating agent) control cotton in seedling stage damping off field trial, verified that this medicament is to the control efficiency of cotton damping off, effective dose and to the safety of cotton.Test is located at the Weinan City Dengcheng County, and the experimental field physical features is smooth, and soil is clay, and fertility is better-than-average, pH value 7.3, and the duration of test rich water quality management is medium.
Test medicine and dosage are: 32% oxazole bacterium ketone fluorine pyrrole bacterium amine suspension seed-coating agent 70g/100kg seed, 60g/100kg seed, 50g/100kg seed; 21% oxazole bacterium ketone iprovalicarb suspension seed-coating agent 80g/100kg seed, 70g/100kg seed, 60g/100kg seed; 20% oxazole bacterium ketone suspending agent 200g/100kg seed; 10% fluorine pyrrole bacterium amine suspending agent 100g/100kg seed, 10% iprovalicarb suspending agent 100g/100kg seed.Other establishes clear water contrast, and every processing repeats for 4 times, every sub-district area 30 ㎡, and totally 40 sub-districts, district's group is arranged at random.
Dressing and seed dressing method: each handles medicine, kind amount by 4 repetitions (120 ㎡); Earlier with the medicament thin up that weighs up; Amount of water is pressed the 1500mL/100kg seed and is calculated, and then soup is slowly poured on the seed of getting ready, and the limit bevelling stirs and makes soup be evenly distributed to every the surface of the seed; Vexed kind 12 hours is dried fully in the cool then and is broadcast.The quantitative hand slide of artificial trench digging method is adopted in sowing.
Investigation and statistical method are handled back the 20th d and are checked disease seedling rate and the influence to emerging and growing, and calculate control efficiency.
Preventive effect (%)=(contrasting the sick seedling rate of disease seedling rate-processing)/contrast death rate * 100
Field test results shows: 32% oxazole bacterium ketone fluorine pyrrole bacterium amine suspension seed-coating agent, 21% oxazole bacterium ketone iprovalicarb suspension seed-coating agent have than remarkable prevention effect the cotton damping off.These two kinds of medicaments are pressed 70g/100kg seed, 60g/100kg seed respectively, and 80g/100kg seed, 70g/100kg seed consumption are respectively 89.05%, 86.22% and 90.25%, 87.16% to the preventive effect of cotton damping off.Obviously be superior to 20% oxazole bacterium ketone suspending agent 200g/100kg seed, 10% fluorine pyrrole bacterium amine suspending agent 100g/100kg seed, the 10% iprovalicarb suspending agent 100g/100kg seed treatment preventive effect to the cotton damping off, preventive effect difference reaches utmost point significance level (seeing table 3 for details).
Duration of test is observed, and each chemicals treatment is not emerged and grown cotton and exerts an influence.
After result of the test Biao Ming oxazole bacterium ketone and fluorine pyrrole bacterium amine or iprovalicarb are mixed, obviously having improved the control efficiency to the cotton damping off, reduced dosage and drug cost, to cotton growth safety, is the desirable medicament of control cotton damping off.
Biological Examples 2: control peronophythora litchi field trial
Carried out FORMULATION EXAMPLE 1 (42% oxazole bacterium ketone fluorine pyrrole bacterium amine water dispersible granules), FORMULATION EXAMPLE 12 (44% oxazole bacterium ketone iprovalicarb suspending agent) control peronophythora litchi field trial in 2011 in Conghua City, Guangdong Province, verified that this medicament is to the control efficiency of peronophythora litchi, effective dose and to the safety of lichee.Test method is with reference to " GB/T 17980.100-2004 pesticide field efficacy medicine test criterion (two) the bactericidal agent for preventing and treating peronophythora litchi test of pesticide effectiveness ".Trial crops is a lichee, and controlling object is peronophythora litchi (Peronophythora litchic).The test kind is a glutinous rice wrapped in lotus leaves, the age of tree 12 years, and growing way is general.Experimental field be the level land, soil is red soil, and fertility is general, experimental field the cultivation condition uniformity.
Test medicine and dosage are: 3000 times, 3500 times, 4000 times of 42% oxazole bacterium ketone fluorine pyrrole bacterium amine water dispersible granules; 3000 times, 3500 times, 4000 times of 44% oxazole bacterium ketone iprovalicarb suspending agents; 1000 times of 20% oxazole bacterium ketone suspending agents; 1000 times of 10% fluorine pyrrole bacterium amine suspending agents, 1000 times of 10% iprovalicarb suspending agents.Other establishes blank, and every processing 4 times repeats, 3 trees in every sub-district, and totally 40 sub-districts, district's group is arranged at random.With agricultural HD-400 type sprayer even spraying.Lichee young fruit period and each dispenser of fruit expanding period 1 time, dispenser is 2 times altogether.
Investigation and statistical method:
Before gathering, carry out the disease index investigation, each sub-district random searching 2 strain, East, West, South, North, middle sampling are pressed in every strain, investigate 30 of fruits at every, and the total fruit of record investigation number, disease fruit number at different levels calculate disease index.
Sick fruit stage division:
0 grade: anosis;
1 grade: scab accounts for the fruit area below 10%;
3 grades: scab accounts for fruit area 11%～25%;
5 grades: scab accounts for fruit area 26%～50%;
7 grades: scab accounts for the fruit area more than 50%.
Disease index and control efficiency computational methods:
Diseased fruit rate (%)=(the total fruit of investigation number/disease fruit number) * 100
Disease index=[∑ (sick fruit number * relative level numerical value at different levels)/(the total fruit of investigation number * 7)] * 100
Control efficiency (%)=[(contrast disease index-processing disease index)/contrast disease index] * 100
Security survey and to the influence of other biological: sprayed behind the medicine the 1st day at every turn and medicine after some days, each handles the influence to lichee to observe medicament.
Field test results shows; 42% oxazole bacterium ketone fluorine pyrrole bacterium amine water dispersible granules, 44% oxazole bacterium ketone iprovalicarb suspending agent have good control efficiency to peronophythora litchi; Each dilutes 3000 times, 3500 times, 4000 times sprayings, investigation before the results after the dispenser second time, and diseased fruit rate is than the apparent reduction of illumination; Preventive effect is respectively 86.15%, 82.04%, 76.32% and 87.28%, 83.60%, 78.65%; Obviously be superior to 1000 times of 20% oxazole bacterium ketone suspending agents, 1000 times of 10% fluorine pyrrole bacterium amine suspending agents, the preventive effect that 10% iprovalicarb suspending agent is 1000 times.
Through each sub-district preventive effect is carried out biostatistics analysis (seeing table 4); Significance of difference comparative result shows: on 0.05 level with 0.01 level on the significance of difference consistent; Significant difference between 3000 times, 3500 times, 4000 times of the 42% oxazole bacterium ketone fluorine pyrrole bacterium amine water dispersible granules; Significant difference between 3000 times, 3500 times, 4000 times of the 44% oxazole bacterium ketone iprovalicarb suspending agents; Three variable concentrations of these two kinds of medicaments all with 1000 times of 20% oxazole bacterium ketone suspending agents, difference is extremely remarkable between 1000 times of the 10% fluorine pyrrole bacterium amine suspending agents, 1000 times of 10% iprovalicarb suspending agents.
Duration of test is observed, each chemicals treatment not to the flower of lichee, really, leaf produces the poisoning phenomenon.
After result of the test Biao Ming oxazole bacterium ketone and fluorine pyrrole bacterium amine, iprovalicarb are mixed, obviously having improved the control efficiency to peronophythora litchi, reduced dosage and drug cost, to lichee growth safety, is the desirable medicament of control peronophythora litchi.
Claims (6)
1. bactericidal composition that contains oxazole bacterium ketone is characterized in that comprising:
A) a property one-tenth alive divides oxazole bacterium ketone;
B) second active component fluorine pyrrole bacterium amine or the iprovalicarb;
The weight ratio of first active component and second active component is 1:5 ~ 15:1.
2. according to the bactericidal composition of the said Han oxazole of claim 1 bacterium ketone, it is characterized in that: the weight ratio of first active component and second active component is 1:2 ~ 2:1.
3. according to the bactericidal composition of claim 1 or 2 said Han oxazole bacterium ketone, it is characterized in that: the cumulant of first active component and second active component is 5%～90% of a said composition total weight.
4. according to the bactericidal composition of the said Han oxazole of claim 3 bacterium ketone, it is characterized in that: the cumulant of first active component and second active component is 10%～70% of a said composition total weight.
5. according to the bactericidal composition of the said Han oxazole of claim 1 bacterium ketone, it is characterized in that: said combination dosage form is water dispersible granules, wetting powder, suspending agent or suspension seed-coating agent.
6. the application of the bactericidal composition of the said Han oxazole of claim 1 bacterium ketone on control crops downy mildew, eqpidemic disease, damping off, peronospora tabacina.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102845441A (en) * | 2012-10-08 | 2013-01-02 | 陕西省蒲城美尔果农化有限责任公司 | Bactericidal composition containing iprovalicarb and famoxadone |
| CN104957170A (en) * | 2012-09-06 | 2015-10-07 | 陕西美邦农药有限公司 | Sterilization composition containing zoxamide |
| CN113841701A (en) * | 2021-10-29 | 2021-12-28 | 江西劲农作物保护有限公司 | Suspending agent for preventing and treating potato late blight |
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| CN1610504A (en) * | 2001-08-24 | 2005-04-27 | 拜尔农作物科学股份公司 | Fungicide active substance combinations |
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| US5453531A (en) * | 1990-08-25 | 1995-09-26 | Bayer Aktiengesellschaft | Substituted valinamide derivatives |
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| CN104957170A (en) * | 2012-09-06 | 2015-10-07 | 陕西美邦农药有限公司 | Sterilization composition containing zoxamide |
| CN102845441A (en) * | 2012-10-08 | 2013-01-02 | 陕西省蒲城美尔果农化有限责任公司 | Bactericidal composition containing iprovalicarb and famoxadone |
| CN113841701A (en) * | 2021-10-29 | 2021-12-28 | 江西劲农作物保护有限公司 | Suspending agent for preventing and treating potato late blight |
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Application publication date: 20120808 |