CN102349531A - Bactericidal composition containing coumoxystrobin and benzimidazole bactericide - Google Patents
Bactericidal composition containing coumoxystrobin and benzimidazole bactericide Download PDFInfo
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- CN102349531A CN102349531A CN2011102695656A CN201110269565A CN102349531A CN 102349531 A CN102349531 A CN 102349531A CN 2011102695656 A CN2011102695656 A CN 2011102695656A CN 201110269565 A CN201110269565 A CN 201110269565A CN 102349531 A CN102349531 A CN 102349531A
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Abstract
The invention discloses a bactericidal composition containing coumoxystrobin and benzimidazole bactericide. The bactericidal composition comprises the coumoxystrobin serving as an active ingredient and the benzimidazole bactericide selected from thiophanatemethyl, carbendazol or benomyl; and the weight ratio of the coumoxystrobin to the benzimidazole bactericide is 1:1-1:50. The composition can be prepared into agriculturally allowable water dispersible granules, wettable powder or suspension. The composition has reasonable components, good bactericidal effect and low application cost, and the activity and the bactericidal effect of the composition are not simply superposed activity and bactericidal effect of the components; compared with the conventional single preparation, the composition has the advantages of remarkable bactericidal effect, remarkable synergy, retarded resistance, low preparation residue, no pollution to crops, good safety and accordance with the safety requirement of the pesticide preparation; and the composition has remarkable effect of preventing and controlling apple ring rot, anthracnose, rot, rice sheath blight, rice blast and wheat scab.
Description
Technical field
The present invention relates to a kind of bactericidal composition that contains SYP-3375; Contain SYP-3375 as first active component particularly a kind of comprising; Be selected from of bactericidal composition and the application thereof of the benzimidazole germicide of thiophanate-methyl, carbendazim, benomyl, belong to technical field of compounded pesticide as second active component.
Background technology
The methoxy acrylic acid series bactericidal agent is a bactericide kind newly developed in recent years, is a big milestone in the bactericide field.Methoxy acrylic bactericide has unique mechanism of action, and it stops the ATP of cell synthetic through the electronics transmission of pinning between cytochrome b and the c1, thereby suppresses its mitochondrial respiratory and bring into play bacteriostasis.The bacterial strain that 14-demethylation enzyme inhibitor, benzamides, dicarboxylic dihydrazides amine and benzimidazole is produced resistance is effective.Have protection, treat, root out, infiltration, systemic activity, and can be in plant corpus, degraded very soon in soil and the water.Although this series bactericidal agent mechanism of action is unique, pathogen is also very fast to the speed that it produces resistance, and use cost is high, promotes the use of so limited the large tracts of land of methoxy acrylic acid series bactericidal agent.
SYP-3375 is a kind of methoxy-methyl acrylate compounds, English common name: coumoxystrobin, and chemical name: (E)-2-(2-((3-butyl-4-methyl-coumarin-7-Ji-oxygen base) methyl) phenyl)-3-methoxy-methyl acrylate.Have protection and therapeutic action; Be a kind of disinfectant use in agriculture of high-efficiency broad spectrum, to by mastigomycetes, combine plant disease that bacterium, sac fungi, basidiomycetes and imperfect fungus cause such as sclerotinia rot of colza, apple valsa canker, cucumber downy mildew, rice blast, sigatoka, alternaria leaf spot of apple etc. that good preventive effect is arranged.
Benzimidazole germicide is to be one type of organic bactericide of parent with the benzimidazole ring that bactericidal activity is arranged, and inhales bactericidal activity in nearly all this compounds all shows, wherein representative compound has benomyl, carbendazim, thiophanate-methyl etc.The sixties in 20th century, these series bactericidal agent series of products successively came out.Fungicidal spectrum is wide, and is better to effects such as botrytis, sickle-like bacteria, sclerotinite, verticillium sp, rhizoctonias except that oomycetes, but uses for many years, and multiple pathogen develops immunity to drugs to it.
Thiophanate-methyl has another name called thiophanate methyl, English common name Thiophanate-Methyl, and chemical name: 1,2-pair-(3-carbethoxyl group-a-ghiourea group) benzene.Thiophanate-methyl belongs to benzimidazole, is to inhale the low toxicity bactericide in a kind of broad spectrum activity, can prevent and treat the various crop disease, has interior suction, prevention and therapeutic action.It is converted into carbendazim in plant corpus, the formation of spindle influences cell division in the mitosis of interference bacterium.
Carbendazim has another name called carbendazol, carbendazol.English common name carbendazim, chemical name: N-(2-benzimidazolyl)-methyl carbamate.Carbendazim is a kind of broad-spectrum germicide, inhales treatment and protective effect in having, and various crop is had control efficiency by the disease that fungi (like imperfect fungus, sac fungi) causes.The mechanism of action is the formation of spindle in the mitosis of disturbing bacterium, thereby influences cell division.Can be used for foliar spray, seed treatment and soil treatment etc.
Benomyl has another name called benomyl, English common name benomyl, chemical name: 1-n-butyl amine base formyl-methyl 2-benzimidazolecarbamate.Benomyl is a kind of efficient, wide spectrum, systemic fungicide, effects such as having protection, treat and root out, and the multiple diseases that can be used for preventing and treating crops such as vegetables, fruit tree, rice wheat is used always and is made seed dressing, spraying and soil treatment.
Although SYP-3375 is a kind of disinfectant use in agriculture of high-efficiency broad spectrum, it is as methoxy acrylic ester compounds, and the mechanism of action is single, and upward long-term repeated use germ is used in the field can produce resistance, cause preventive effect to reduce, and use cost is high.Above-mentioned benzimidazole germicide thiophanate-methyl, carbendazim, benomyl have used for many years; Pathogen has produced very big resistance to it; It is increasing to use dosage separately, uses resistance to strengthen year by year for many years, the patent report that does not also have these three kinds of agricultural chemicals and SYP-3375 to be mixed at present.The inventor finds through test; SYP-3375 and benzimidazole germicide that the mechanism of action is different are composite; Has obvious synergistic effect; Can significantly improve control efficiency, minimizing spraying times and the dosage of treatment, protection; Slow down the generation of germ resistance; Reduce the control cost, high to crop safety.
Summary of the invention
The object of the present invention is to provide a kind of component reasonable, synergistic effect is remarkable, and bactericidal effect is good, and drug cost is low, is difficult for developing immunity to drugs, to the bactericidal composition of crop safety.
Another object of the present invention is to provide above-mentioned composition in the application that prevents and treats on ring rot of apple, anthracnose, rot, rice sheath blight disease, rice blast, the wheat scab.
In order to overcome the defective of existing single preparation, technical scheme of the present invention is to solve like this:
A) the first active component SYP-3375;
B) the second active component benzimidazole germicide is selected from a kind of in thiophanate-methyl, carbendazim, the benomyl;
The weight ratio of first active component and second active component is 1:1～1:50, is preferably 1:1～1:30, most preferably is 1:2～1:30.
The cumulant of first active component and second active component is 5%～90% of a said composition total weight, is preferably 10%～60%, and the size of active component cumulant is also closely related with formulation, as the active component cumulant of suspending agent, is no more than 50%.
The preparation formulation that a kind of bactericidal composition that contains SYP-3375 and benzimidazole germicide of the present invention can be prepared according to the known method of those skilled in the art of the present technique is water dispersible granules, wetting powder, suspending agent.
For water dispersible granules, those skilled in the art are familiar with the use corresponding adjuvants and accomplish the present invention very much.In dispersant such as polycarboxylate, lignosulfonates, the alkylnaphthalene sulfonate one or more; In wetting agent such as alkyl sulfate, alkylsulfonate, the naphthalene sulfonate one or more; In disintegrant such as ammonium sulfate, urea, sucrose, the glucose one or more; In binding agent such as diatomite, corn starch, PVA, carboxymethyl (ethyl) cellulose family one or more; Filler such as diatomite, kaolin, white carbon, fine particle calcium carbonate, talcum powder, attapulgite, potter's clay one or more.
To wetting powder, spendable auxiliary agent has: in dispersant such as polycarboxylate, lignosulfonates, the alkylnaphthalene sulfonate one or more; In wetting agent such as alkyl sulfate, alkylsulfonate, the naphthalene sulfonate one or more; Filler such as ammonium sulfate, urea, sucrose, glucose, diatomite, kaolin, white carbon, fine particle calcium carbonate, talcum powder, attapulgite, potter's clay one or more.
To suspending agent, spendable auxiliary agent has: among dispersant such as polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate (dispersing agent NNO), the TERSPERSE 2020 (U.S. Huntsman Corporation produces, the alkyl naphthalene sulfonic acid salt) one or more; Alkyl phenol formaldehyde resin polyoxyethylene ether), agricultural newborn 2201#, this dish-60# (common name: Span60), Tween-60 # (common name: the polyoxyethylene sorbitan stearate), agricultural newborn 1601# (common name: triphen ethyl-phenol polyoxyethylene polyoxypropylene block polymer), among the TERSPERSE 4894 (U.S. Huntsman Corporation product) one or more emulsifier such as Nongru-700 # (common name:; Among wetting agent such as alkylphenol-polyethenoxy base ether formaldehyde condensation products sulphate, alkylphenol-polyethenoxy base ether phosphate, phenethyl phenol polyethenoxy base ether phosphate, alkyl sulfate, alkylsulfonate, naphthalene sulfonate, the TERSPERSE 2500 (U.S. Huntsman Corporation product) one or more; In thickener such as xanthans, polyvinyl alcohol, bentonite, the aluminium-magnesium silicate one or more; In preservative such as formaldehyde, benzoic acid, the Sodium Benzoate one or more; In stabilizing agent such as epoxychloropropane, the triphenyl phosphate one or more; Defoamer such as organic silicon defoamer; In antifreezing agent such as ethylene glycol, propane diols, glycerine, urea, inorganic salts such as the sodium chloride one or more; Water is deionized water.
Component of the present invention is reasonable; Treatment adds protective effect; Bactericidal effect is good; Reduce the medication number of times, drug cost is low, and its active and bactericidal effect is not the simple superposition of each composition activity; But significant synergistic effect is arranged; Slow down the generation of resistance, good to crop safety, meet the security requirement of pesticidal preparations.The present invention has the better prevention effect to ring rot of apple, anthracnose, rot, rice sheath blight disease, rice blast, wheat scab.
Embodiment
In order to prevent and treat the ring rot of apple in the agricultural production, the inventor is with SYP-3375 and benzimidazole germicide: thiophanate-methyl, carbendazim, benomyl have carried out mutual composite synergy research, and concrete grammar is:
It is tested object that ring rot of apple bacterium (Macrophoma kawatsukai Hara) is adopted in test.The former medicine of test medicine SYP-3375 adopts Jilin eight to reach the former medicine that agricultural chemicals Co., Ltd produces, the former medicine that benzimidazole germicide thiophanate-methyl, the former medicine of benomyl adopt Jiangsu Lam Fung Biological Chemical Co., Ltd, carbendazim active compound to adopt Guangxin, Anhui farmingization limited company to produce.By technology department of Shanggezhilu Biosciences Co., Ltd., Shaanxi former medicine is mixed with the test medicine that needs, test method is with reference to " the agricultural industry criteria NY/T1156.2-2006 of the People's Republic of China (PRC) ".At first single agent and each Mixed Pharmacy are provided with 5 variable concentrations gradients (on preliminary experiment result's basis, different with proportioning according to different medicament combinations, the concentration gradient setting is also different, and bacteriostasis rate is set by geometric progression) in 5%～90% scope.If the clear water contrast repeats 3 times.Adopt the mycelial growth rate method, with cultured pathogen, under aseptic condition, using diameter is 5 mm card punch, cuts the bacterium cake from colony edge, with transfer needle the bacterium cake is connected on the culture medium flat plate of different drug concentrations, puts in 26 ℃ of incubators and cultivates 72h; The inspection colony diameter calculates the percentage that each chemicals treatment suppresses mycelial growth, and the EC of each medicament is obtained in the linear regression analysis between the probit value through inhibiting rate and the logarithm value of series concentration
50Value with the co-toxicity coefficient (CTC) of the abundant method calculating of Sun Yun mixture, is estimated the activity of confession reagent agent to germ with this.
The co-toxicity coefficient of complex preparation (CTC)>=120 shows as synergistic effect; CTC≤80 show as antagonism; 80＜CTC＜120 show as summation action.
Toxicity Determination result shows: SYP-3375 and benzimidazole germicide: a kind of in thiophanate-methyl, carbendazim, the benomyl is that 1:1～1:50 uses with ring rot of apple is had virulence preferably with the weight ratio, and significant synergistic effect is all arranged.
In order to prevent and treat the apple anthracnose in the agricultural production; The inventor is with SYP-3375 and benzimidazole germicide: thiophanate-methyl, carbendazim, benomyl have carried out mutual composite synergy research; It is tested object that apple anthrax bacteria (Gleosporium fructigenum Berk) is adopted in test; Test medicine is identical with above-mentioned experiment, and test method is with reference to " the agricultural industry criteria NY/T1156.2-2006 of the People's Republic of China (PRC) ".At first single agent and each Mixed Pharmacy are provided with 5 variable concentrations gradients (on preliminary experiment result's basis, different with proportioning according to different medicament combinations, the concentration gradient setting is also different, and bacteriostasis rate is set by geometric progression) in 5%～90% scope.If the clear water contrast repeats 3 times.Adopt the mycelial growth rate method, with cultured pathogen, under aseptic condition, using diameter is 5 mm card punch, cuts the bacterium cake from colony edge, with transfer needle the bacterium cake is connected on the culture medium flat plate of different drug concentrations, puts in 26 ℃ of incubators and cultivates 72h; The inspection colony diameter calculates the percentage that each chemicals treatment suppresses mycelial growth, and the EC of each medicament is obtained in the linear regression analysis between the probit value through inhibiting rate and the logarithm value of series concentration
50Value with the co-toxicity coefficient (CTC) of the abundant method calculating of Sun Yun mixture, is estimated the activity of confession reagent agent to germ with this.
Toxicity Determination result shows: SYP-3375 and benzimidazole germicide: a kind of in thiophanate-methyl, carbendazim, the benomyl is that 1:1～1:50 uses with apple anthracnose is had virulence preferably with the weight ratio, and significant synergistic effect is all arranged.
In order to prevent and treat the apple valsa canker in the agricultural production; The inventor is with SYP-3375 and benzimidazole germicide: thiophanate-methyl, carbendazim, benomyl have carried out mutual composite synergy research; Subjects: apple valsa canker (Cytospora mandshurica); Test medicine is identical with above-mentioned experiment, and test method is with reference to " the agricultural industry criteria NY/T1156.2-2006 of the People's Republic of China (PRC) ".At first single agent and each Mixed Pharmacy are provided with 5 variable concentrations gradients (on preliminary experiment result's basis, different with proportioning according to different medicament combinations, the concentration gradient setting is also different, and bacteriostasis rate is set by geometric progression) in 5%～90% scope.Molten good PDA medium is cooled to 60-70 ℃; Press design flow and add quantitative pharmacy, process the toxic medium that contains different doses, repeat 3 times; After treating that it fully cools off; The inoculation diameter is the Valsa mali sheet of 0.5cm, places and cultivates (25 ℃ ± 1 ℃ of temperature) in the incubator, investigates in 5 days; Measure the colony growth diameter of each processing respectively; And the calculating bacteriostasis rate, the EC of each medicament is obtained in the linear regression analysis between the probit value through inhibiting rate and the logarithm value of series concentration
50Value with the co-toxicity coefficient (CTC) of the abundant method calculating of Sun Yun mixture, is estimated the activity of confession reagent agent to germ with this.
Toxicity Determination result shows: SYP-3375 and benzimidazole germicide: a kind of in thiophanate-methyl, carbendazim, the benomyl is that 1:1～1:50 uses with apple canker is had virulence preferably with the weight ratio, and significant synergistic effect is all arranged.
In order to prevent and treat the rice sheath blight disease in the agricultural production; The inventor is with SYP-3375 and benzimidazole germicide: thiophanate-methyl, carbendazim, benomyl have carried out mutual composite synergy research; Subjects is Rhizoctonia solani Kuhn (Rhizoctonia solani); Test medicine is identical with above-mentioned experiment; By technology department of Shanggezhilu Biosciences Co., Ltd., Shaanxi former medicine is mixed with the test medicine that needs, test method is with reference to " the agricultural industry criteria NY/T1156.2-2006 of the People's Republic of China (PRC) ".At first single agent and each Mixed Pharmacy are provided with 5 variable concentrations gradients (on preliminary experiment result's basis, different with proportioning according to different medicament combinations, the concentration gradient setting is also different, and bacteriostasis rate is set by geometric progression) in 5%～90% scope.If the clear water contrast repeats 3 times.Adopt the mycelial growth rate method, with cultured pathogen, the use diameter is 5 mm card punch under aseptic condition, cuts the bacterium cake from colony edge, with transfer needle the bacterium cake is connected on the culture medium flat plate of different drug concentrations, puts in 27 ℃, saturated humidity incubator and cultivates; When treating that the control group bacterium colony covers with, measure colony diameter, calculate the percentage that each chemicals treatment suppresses mycelial growth, the EC of each medicament is obtained in the linear regression analysis between the probit value through inhibiting rate and the logarithm value of series concentration
50Value with the co-toxicity coefficient (CTC) of the abundant method calculating of Sun Yun mixture, is estimated the activity of confession reagent agent to germ with this.
Toxicity Determination result shows: SYP-3375 and benzimidazole germicide: a kind of in thiophanate-methyl, carbendazim, the benomyl is that 1:1～1:50 uses with rice sheath blight disease is had virulence preferably with the weight ratio, and significant synergistic effect is all arranged.
In order to prevent and treat the rice blast in the agricultural production; The inventor is with SYP-3375 and benzimidazole germicide: thiophanate-methyl, carbendazim, benomyl have carried out mutual composite synergy research; Subjects is Pyricularia oryzae (Pyriculariagrisea); Test medicine is identical with above-mentioned experiment; By technology department of Shanggezhilu Biosciences Co., Ltd., Shaanxi former medicine is mixed with the test medicine that needs, test method is with reference to " the agricultural industry criteria NY/T1156.2-2006 of the People's Republic of China (PRC) ".At first single agent and each Mixed Pharmacy are provided with 5 variable concentrations gradients (on preliminary experiment result's basis, different with proportioning according to different medicament combinations, the concentration gradient setting is also different, and bacteriostasis rate is set by geometric progression) in 5%～90% scope.If the clear water contrast repeats 3 times.Adopt the mycelial growth rate method, with cultured pathogen, the use diameter is 5 mm card punch under aseptic condition, cuts the bacterium cake from colony edge, with transfer needle the bacterium cake is connected on the culture medium flat plate of different drug concentrations, puts in 27 ℃, saturated humidity incubator and cultivates; When treating that the control group bacterium colony covers with, measure colony diameter, calculate the percentage that each chemicals treatment suppresses mycelial growth, the EC of each medicament is obtained in the linear regression analysis between the probit value through inhibiting rate and the logarithm value of series concentration
50Value with the co-toxicity coefficient (CTC) of the abundant method calculating of Sun Yun mixture, is estimated the activity of confession reagent agent to germ with this.
Toxicity Determination result shows: SYP-3375 and benzimidazole germicide: a kind of in thiophanate-methyl, carbendazim, the benomyl is that 1:1～1:50 uses with Pyricularia oryzae is had virulence preferably with the weight ratio, and significant synergistic effect is all arranged.
In order to prevent and treat the wheat scab in the agricultural production; The inventor is with SYP-3375 and benzimidazole germicide: thiophanate-methyl, carbendazim, benomyl have carried out mutual composite synergy research; Subjects is wheat scab (Fusarium graminearum); Test medicine is identical with above-mentioned experiment; By technology department of Shanggezhilu Biosciences Co., Ltd., Shaanxi former medicine is mixed with the test medicine that needs, test method is with reference to " the agricultural industry criteria NY/T1156.2-2006 of the People's Republic of China (PRC) ".At first single agent and each Mixed Pharmacy are provided with 5 variable concentrations gradients (on preliminary experiment result's basis, different with proportioning according to different medicament combinations, the concentration gradient setting is also different, and bacteriostasis rate is set by geometric progression) in 5%～90% scope.If the clear water contrast repeats 3 times.Adopt the mycelial growth rate method, with cultured pathogen, the use diameter is 5 mm card punch under aseptic condition, cuts the bacterium cake from colony edge, with transfer needle the bacterium cake is connected on the culture medium flat plate of different drug concentrations, puts in 27 ℃, saturated humidity incubator and cultivates; When treating that the control group bacterium colony covers with, measure colony diameter, calculate the percentage that each chemicals treatment suppresses mycelial growth, the EC of each medicament is obtained in the linear regression analysis between the probit value through inhibiting rate and the logarithm value of series concentration
50Value with the co-toxicity coefficient (CTC) of the abundant method calculating of Sun Yun mixture, is estimated the activity of confession reagent agent to germ with this.
Toxicity Determination result shows: SYP-3375 and benzimidazole germicide: one of thiophanate-methyl, carbendazim, benomyl are that 1:1～1:50 uses with wheat scab is had virulence preferably with the weight ratio, and significant synergistic effect is all arranged.
Below in conjunction with FORMULATION EXAMPLE and biological Examples content of the present invention is described further.
FORMULATION EXAMPLE 1
Take by weighing 10% SYP-3375,60% thiophanate-methyl, 3% TERSPERSE 2700 (polycarboxylate, U.S. Huntsman Corporation produces), 2% dispersing agent NNO (alkylnaphthalene sulfonate formaldehyde condensation products), 3% Nekal BX (nekal), 2% K-12 (lauryl sodium sulfate), 3% diatomite, 5% glucose, kaolin adds to 100% weight portion.The method of the frequent regulation of above-mentioned raw materials water intaking dispersible granule is promptly mixed, ultra micro comminution by gas stream, mixing, granulation step are produced 70% SYP-3375 thiophanate-methyl water dispersible granules.
FORMULATION EXAMPLE 2
Take by weighing 1.5% SYP-3375,75% thiophanate-methyl, 3% TERSPERSE 2700,3% dispersing agent NNO, 2% Nekal BX, 1%K-12,1% carboxymethyl cellulose, 3% urea, diatomite adds to 100% weight portion.The method of the frequent regulation of above-mentioned raw materials water intaking dispersible granule is promptly mixed, ultra micro comminution by gas stream, mixing, granulation step are produced 76.5% SYP-3375 thiophanate-methyl water dispersible granules.
FORMULATION EXAMPLE 3
Take by weighing 8% SYP-3375,40% thiophanate-methyl, 4% TERSPERSE 2700,2% dispersing agent NNO, 2% Nekal BX, 2%K-12,3% corn starch, 5% ammonium sulfate, attapulgite adds to 100% weight portion.The method of the frequent regulation of above-mentioned raw materials water intaking dispersible granule is promptly mixed, ultra micro comminution by gas stream, mixing, granulation step are produced 48% SYP-3375 thiophanate-methyl water dispersible granules.
FORMULATION EXAMPLE 4
Take by weighing 10% SYP-3375,80% carbendazim, 3% Morwet D-425 (alkyl naphthalene sulfonic acid condensation polymer sodium salt, Akzo Nobel N.V. produces), 1%K-12,2% ammonium sulfate, diatomite adds to 100% weight portion.The method of the frequent regulation of above-mentioned raw materials water intaking dispersible granule is promptly mixed, ultra micro comminution by gas stream, mixing, granulation step are produced 90% SYP-3375 carbendazim water dispersing granule.
FORMULATION EXAMPLE 5
Take by weighing 20% SYP-3375,60% carbendazim, 3% TERSPERSE 2700,3% dispersing agent NNO, 2% Nekal BX, 2%K-12,1% carboxymethyl cellulose, 3% sucrose, diatomite adds to 100% weight portion.The method of the frequent regulation of above-mentioned raw materials water intaking dispersible granule is promptly mixed, ultra micro comminution by gas stream, mixing, granulation step are produced 80% SYP-3375 carbendazim water dispersing granule.
FORMULATION EXAMPLE 6
Take by weighing 15% SYP-3375,35% carbendazim, 3% TERSPERSE 2700,2% dispersing agent NNO, 1% Nekal BX, 1%K-12,2% corn starch, 3% ammonium sulfate, attapulgite adds to 100% weight portion.The method of the frequent regulation of above-mentioned raw materials water intaking dispersible granule is promptly mixed, ultra micro comminution by gas stream, mixing, granulation step are produced 50% SYP-3375 carbendazim water dispersing granule.
FORMULATION EXAMPLE 7
Take by weighing 30% SYP-3375,30% benomyl, 3% TERSPERSE 2700,2% dispersing agent NNO, 3% Nekal BX, 2%K-12,5% glucose, diatomite soil adds to 100% weight portion.The method of the frequent regulation of above-mentioned raw materials water intaking dispersible granule is promptly mixed, ultra micro comminution by gas stream, mixing, granulation step are produced 60% SYP-3375 benomyl water dispersible granules.
FORMULATION EXAMPLE 8
Take by weighing 5% SYP-3375,45% benomyl, 3% TERSPERSE 2700,3% dispersing agent NNO, 2% Nekal BX, 1%K-12,1% carboxymethyl cellulose, 3% urea, diatomite adds to 100% weight portion.The method of the frequent regulation of above-mentioned raw materials water intaking dispersible granule is promptly mixed, ultra micro comminution by gas stream, mixing, granulation step are produced 50% SYP-3375 benomyl water dispersible granules.
FORMULATION EXAMPLE 9
Take by weighing 15% SYP-3375,45% benomyl, 3% TERSPERSE 2700,2% dispersing agent NNO, 3% Nekal BX, 2%K-12,3% diatomite, 5% glucose, kaolin adds to 100% weight portion.The method of the frequent regulation of above-mentioned raw materials water intaking dispersible granule is promptly mixed, ultra micro comminution by gas stream, mixing, granulation step are produced 60% SYP-3375 benomyl water dispersible granules.
FORMULATION EXAMPLE 10
Take by weighing 10% SYP-3375,80% thiophanate-methyl, 2% sodium lignin sulfonate, 2% dispersing agent NNO, 1% Nekal BX, 1%K-12, attapulgite and add to 100% weight portion.Above-mentioned raw materials makes 90% SYP-3375 thiophanate-methyl wetting powder through mixing behind the comminution by gas stream.
FORMULATION EXAMPLE 11
Take by weighing 20% SYP-3375,40% thiophanate-methyl, 4% calcium lignosulfonate, 3% TERSPERSE 2700,2% Nekal BX, 2%K-12,3% white carbon black, fine particle calcium carbonate adds to 100% weight portion.Above-mentioned raw materials makes 60% SYP-3375 thiophanate-methyl wetting powder through mixing behind the comminution by gas stream.
FORMULATION EXAMPLE 12
Take by weighing 30% SYP-3375,50% carbendazim, 3% calcium lignosulfonate, 3% dispersing agent NNO, 2% Nekal BX, 2%K-12, white carbon black adds to 100% weight portion.Above-mentioned raw materials makes 80% SYP-3375 carbendazol wettable powder through mixing behind the comminution by gas stream.
FORMULATION EXAMPLE 13
Take by weighing 10% SYP-3375,40% carbendazim, 4% calcium lignosulfonate, 3% TERSPERSE 2700,2% Nekal BX, 2%K-12,3% white carbon black, fine particle calcium carbonate adds to 100% weight portion.Above-mentioned raw materials makes 50% SYP-3375 carbendazol wettable powder through mixing behind the comminution by gas stream.
FORMULATION EXAMPLE 14
Take by weighing 8% SYP-3375,42% benomyl, 4% dispersing agent NNO, 2% Nekal BX, 2%K-12, attapulgite and add to 100% weight portion.Above-mentioned raw materials makes 50% SYP-3375 benomyl wetting powder through mixing behind the comminution by gas stream.
FORMULATION EXAMPLE 15
Take by weighing 20% SYP-3375,50% benomyl, 5% calcium lignosulfonate, 2% Nekal BX, 2%K-12, white carbon black adds to 100% weight portion.Above-mentioned raw materials makes 70% SYP-3375 benomyl wetting powder through mixing behind the comminution by gas stream.
FORMULATION EXAMPLE 16
Take by weighing 10% SYP-3375,40% thiophanate-methyl, 4%TERSPERSE 4894 (U.S. Huntsman Corporation product), 1.5%TERSPERSE 2500 (U.S. Huntsman Corporation product), 2%TERSPERSE 2020 (U.S. Huntsman Corporation product), 1% aluminium-magnesium silicate, 0.2% xanthans, 5% ethylene glycol, 0.5% formaldehyde, 0.5% silicone defoaming agent (trade name: s-29 Nanjing "four news" (new ideas applied chemistry article company produces), 2% triphenyl phosphate, deionized water adds to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with the SYP-3375 thiophanate-methyl suspending agent that makes 50% behind the sand mill sand milling.
FORMULATION EXAMPLE 17
Take by weighing 20% SYP-3375,20% thiophanate-methyl, 5%TERSPERSE 4894,2%TERSPERSE 2500,1%TERSPERSE 2020,0.2% xanthans, 5% propane diols, 0.5% benzoic acid, 1% epoxychloropropane, 0.5% silicone defoaming agent, 1% epoxychloropropane, deionized water and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with the SYP-3375 thiophanate-methyl suspending agent that makes 40% behind the sand mill sand milling.
FORMULATION EXAMPLE 18
Take by weighing 8% SYP-3375,42% carbendazim, 2%TERSPERSE 2020,2% this dish-60#, 2% Tween-60 #, 1%TERSPERSE 2500,0.5% white carbon, 0.3% xanthans, 5% ethylene glycol, 0.5% benzoic acid, 0.5% silicone defoaming agent, 1% epoxychloropropane, deionized water and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with the SYP-3375 carbendazim suspending agent that makes 50% behind the sand mill sand milling.
FORMULATION EXAMPLE 19
Take by weighing 20% SYP-3375,30% carbendazim, 1%TERSPERSE 2020,3% agricultural newborn 1601#, 2% agricultural newborn 2201#, 1%TERSPERSE 2500,0.3% xanthans, 5% ethylene glycol, 0.5% formaldehyde, 0.5% silicone defoaming agent, 1% epoxychloropropane, deionized water and add to 100% weight portion.High speed shear is disperseed 30min, with the SYP-3375 carbendazim suspending agent that makes 50% behind the sand mill sand milling.
FORMULATION EXAMPLE 20
Take by weighing 5% SYP-3375,5% benomyl, 4%TERSPERSE 4894,1.5%TERSPERSE 2500,1%TERSPERSE 2020,1% aluminium-magnesium silicate, 5% ethylene glycol, 0.5% formaldehyde, 0.5% silicone defoaming agent, 1% epoxychloropropane, deionized water and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making 10% SYP-3375 benomyl suspending agent behind the sand mill sand milling.
FORMULATION EXAMPLE 21
Take by weighing 15% SYP-3375,25% benomyl, 3%TERSPERSE 4894,1.5%TERSPERSE 2500,1%TERSPERSE 2020,0.2% xanthans, 5% propane diols, 0.5% benzoic acid, 0.5% silicone defoaming agent, 1% epoxychloropropane, deionized water and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making 40% SYP-3375 benomyl suspending agent behind the sand mill sand milling.
Biological Examples 1: prevent and treat the ring rot of apple field trial
Carried out FORMULATION EXAMPLE 1 (70% SYP-3375 thiophanate-methyl water dispersible granules), FORMULATION EXAMPLE 13 (50% SYP-3375 carbendazol wettable powder), FORMULATION EXAMPLE 21 (40% SYP-3375 benomyl suspending agent) in 2010 in suburb, Tai, Shandong and prevented and treated the ring rot of apple field trial, verified that these several medicaments are to the control efficiency of ring rot of apple, effective dose and to the safety of apple.Test method is with reference to " pesticide field efficacy medicine test criterion GB/T 17980.118-2004 ".Trial crops is an apple tree, and controlling object is an apple wheel line decayed fruit sick (Macrophoma kawatsukai).Test is located at Tai, Shandong Province Taishan District, and soil is loam, and physical features is smooth, and soil fertility is even, pH value 6.5, and fertility is better, experimental field the cultivation condition uniformity.Test medicine and dosage are: 1800 times, 2100 times, 2500 times of 70% SYP-3375 thiophanate-methyl water dispersible granules; 1500 times, 1800 times, 2000 times of 50% SYP-3375 carbendazol wettable powders; 2000 times, 2300 times, 2500 times of 40% SYP-3375 benomyl suspending agents; 2000 times of 20% SYP-3375 suspending agents; 800 times of 70% thiophanate-methyl wetting powders; 600 times of 50% carbendazol wettable powders, 600 times of 50% benomyl wetting powders.Other establishes blank, and every processing 4 times repeats, 3 trees in every sub-district, and totally 64 sub-districts, district's group is arranged at random.Adopting conventional spray-on process, is May 8 in the ring rot of apple their early stage, executes medicine the 1st time, and June 9, July 22, each spray test medication on August 22 1 time are sprayed medicine 4 times altogether.Evenly spray each position of tree body, comprise limb, fruit and positive and negative blade, drenched degree of being by soup with limb, fruit and leave dual sides.
Investigation and statistical method, investigation drug effect in gathering before, 1 strain tree is investigated in every sub-district, east, south, west, north, on, in following 6 orientation get 6 points, investigate 30 fruits at every, every tree is investigated 180 fruits, writes down really number of ring spot.Behind each spray medicine behind the 1st day and the medicine some days, each handled the influence to fruit and blade to observe medicament.
Through each sub-district preventive effect is carried out biostatistics analysis (seeing table 7); Significance of difference comparative result shows: on 0.05 level with 0.01 level on the significance of difference consistent; Difference is not remarkable between 2300 times of 1800 times of the 70% SYP-3375 thiophanate-methyl water dispersible granules, 1500 times of 50% SYP-3375 carbendazol wettable powders, 2000 times of 40% SYP-3375 benomyl suspending agents, 40% SYP-3375 benomyl suspending agent, respectively handles differences with other and all reaches utmost point significance level; Difference is not remarkable between 2300 times of 2100 times of the 70% SYP-3375 thiophanate-methyl water dispersible granules, 1800 times of 50% SYP-3375 carbendazol wettable powders, 40% SYP-3375 benomyl suspending agent, respectively handles differences with other and all reaches utmost point significance level; Difference is not remarkable between 600 times of 2500 times of the 70% SYP-3375 thiophanate-methyl water dispersible granules, 2000 times of 50% SYP-3375 carbendazol wettable powders, 2500 times of 40% SYP-3375 benomyl suspending agents, 2000 times of 20% SYP-3375 suspending agents, 800 times of 70% thiophanate-methyl wetting powders, 50% benomyl wetting powder, respectively handles differences with other and all reaches utmost point significance level; Difference is not remarkable between 600 times of 800 times of 70% thiophanate-methyl wetting powders and 50% carbendazol wettable powders, respectively handles differences with other and all reaches utmost point significance level.
Field test results shows: 70% SYP-3375 thiophanate-methyl water dispersible granules, 50% SYP-3375 carbendazol wettable powder, 40% SYP-3375 benomyl suspending agent have than remarkable prevention effect ring rot of apple.1800 times, 2100 times of 70% SYP-3375 thiophanate-methyl water dispersible granules; 1500 times, 1800 times of 50% SYP-3375 carbendazol wettable powders; 2000 times, 2300 times of 40% SYP-3375 benomyl suspending agents obviously are better than the control efficiency of 2000 times of 20% SYP-3375 suspending agents, 800 times of 70% thiophanate-methyl wetting powders, 600 times of 50% carbendazol wettable powders, 600 times of 50% benomyl wetting powders.
To the security survey of apple tree, to observe in some days behind the 1st day and the medicine behind the spray medicine, each test is handled not to be had the poisoning phenomenon to fruit, blade and takes place.
Result of the test has obviously improved the control efficiency to ring rot of apple after showing that SYP-3375 and thiophanate-methyl, carbendazim, benomyl are mixed, and has reduced dosage and drug cost, to apple development safety, is the desirable medicament of control apple tree ring spot.
Biological Examples 2: prevent and treat the rice sheath blight disease field trial
Carried out FORMULATION EXAMPLE 3 (48% SYP-3375 thiophanate-methyl water dispersible granules), FORMULATION EXAMPLE 14 (50% SYP-3375 benomyl wetting powder), FORMULATION EXAMPLE 19 (50% SYP-3375 carbendazim suspending agent) in 2010 in the changde, hunan city and prevented and treated the rice sheath blight disease field trial, verified that these several medicaments are to the control efficiency of paddy rice ring spot, effective dose and to the safety of paddy rice.Trial crops is a paddy rice, and controlling object is rice sheath blight disease (Rhizoctonia solani).Test is located at the changde, hunan province suburban area, soil pH value 7.0, and fertility is better, the content of organic matter about 1.80%, experimental field cultivation condition uniformity.
Test medicine and dosage are: 48% SYP-3375 thiophanate-methyl water dispersible granules 35g/667 ㎡, 30g/667 ㎡, 25g/667 ㎡; 50% SYP-3375 benomyl wetting powder 35g/667 ㎡, 30g/667 ㎡, 25g/667 ㎡; 50% SYP-3375 carbendazim suspending agent 18g/667 ㎡, 15g/667 ㎡, 12g/667 ㎡; 20% SYP-3375 suspending agent 20g/667 ㎡; 70% thiophanate-methyl wetting powder 90g/667 ㎡; 50% carbendazol wettable powder 100g/667 ㎡, 50% benomyl wetting powder 100g/667 ㎡.Other establishes blank, and every processing 4 times repeats, every sub-district area 50 ㎡, and totally 64 sub-districts, district's group is arranged at random.Adopt conventional spray-on process, mu dispenser liquid 60 kg.Paddy rice is in the not phase of tillering during dispenser for the first time, is total to dispenser three times July 16, July 23, July 30.
Investigation and statistical method according to rice leaf sheath and blade damage symptom grading, are unit with the strain, 5 samplings of every sub-district diagonal, and every some investigation links to each other 5 clumps, totally 25 clumps, writes down total strain number, diseased plant number and sick progression.10 d carry out efficacy survey behind the medicine for the third time, and investigation once altogether.The classification of rice sheath blight disease and drug effect are calculated and are undertaken by GB/T17980.20-2000.
Disease index grade standard to be checked the mark:
0 grade: complete stool is anosis;
1 grade: quaterfoil and following each leaf sheath thereof, blade morbidity (is first blade with sword-like leave);
3 grades: the 3rd blade and following each leaf sheath thereof, blade morbidity;
5 grades: the tenth blade and following each leaf sheath thereof, blade morbidity;
7 grades: sword-like leave blade and following each leaf sheath thereof, blade morbidity;
9 grades: the complete stool morbidity, withered ahead of time.
The disease index computational methods:
Disease index=Σ (the sick numbers of sheets at different levels * relative level numerical value)/investigate total number of sheets * 9 * 100%
Disease index * 100% after control efficiency (%)=(disease index after disease index after the dispenser of blank district-chemicals treatment district dispenser)/blank district dispenser
Security survey: sprayed behind the medicine the 1st day at every turn and medicine after some days, observe medicament and respectively handle the influence of paddy rice.
Through each sub-district preventive effect is carried out biostatistics analysis (seeing table 8); Significance of difference comparative result shows: on 0.05 level with 0.01 level on the significance of difference consistent; Difference is not remarkable between 48% SYP-3375 thiophanate-methyl water dispersible granules 35g/667 ㎡, 50% SYP-3375 benomyl wetting powder 35g/667 ㎡, the 50% SYP-3375 carbendazim suspending agent 18g/667 ㎡, respectively handles differences with other and all reaches utmost point significance level; Difference is not remarkable between 48% SYP-3375 thiophanate-methyl water dispersible granules 30g/667 ㎡, 50% SYP-3375 benomyl wetting powder 30g/667 ㎡, the 50% SYP-3375 carbendazim suspending agent 15g/667 ㎡, respectively handles differences with other and all reaches utmost point significance level; Difference is not remarkable between 48% SYP-3375 thiophanate-methyl water dispersible granules 25g/667 ㎡, 50% SYP-3375 benomyl wetting powder 25g/667 ㎡, 50% SYP-3375 carbendazim suspending agent 12g/667 ㎡, 20% SYP-3375 suspending agent 20g/667 ㎡, the 50% benomyl wetting powder 100g/667 ㎡, respectively handles differences with other and all reaches utmost point significance level; Difference is not remarkable between 70% thiophanate-methyl wetting powder 90g/667 ㎡, the 50% carbendazol wettable powder 100g/667 ㎡, respectively handles differences with other and all reaches utmost point significance level.
Field test results shows: 48% SYP-3375 thiophanate-methyl water dispersible granules, 50% SYP-3375 benomyl wetting powder, 50% SYP-3375 carbendazim suspending agent have than remarkable prevention effect rice sheath blight disease.48% SYP-3375 thiophanate-methyl water dispersible granules 35g/667 ㎡, 30g/667 ㎡; 50% SYP-3375 benomyl wetting powder 35g/667 ㎡, 30g/667 ㎡, 50% SYP-3375 carbendazim suspending agent 18g/667 ㎡, 15g/667 ㎡ obviously are better than the control efficiency of 20% SYP-3375 suspending agent 20g/667 ㎡, 70% thiophanate-methyl wetting powder 90g/667 ㎡, 50% carbendazol wettable powder 100g/667 ㎡, 50% benomyl wetting powder 100g/667 ㎡.
To the security survey of paddy rice, to observe in some days behind the 1st day and the medicine behind the spray medicine, each test is handled not to be had the poisoning phenomenon to paddy rice and takes place.
Result of the test has obviously improved the control efficiency to rice sheath blight disease after showing that SYP-3375 and thiophanate-methyl, carbendazim, benomyl are mixed, and has reduced dosage and drug cost, to paddy growth safety, is the desirable medicament of preventing and treating rice sheath blight disease.
Biological Examples 3: prevent and treat the wheat scab field trial
2011 in the Huai Huaiyin District has carried out FORMULATION EXAMPLE 1 (70% SYP-3375 thiophanate-methyl water dispersible granules), FORMULATION EXAMPLE 18 (50% SYP-3375 carbendazim suspending agent), FORMULATION EXAMPLE 21 (40% SYP-3375 benomyl suspending agent) and has prevented and treated the wheat scab field trial, verified that these several medicaments are to the control efficiency of paddy rice ring spot, effective dose and to the safety of wheat.Trial crops is a wheat, and controlling object is wheat scab (Cn'bberelN z (Schw.) Petch).Experimental field preceding crop is a paddy rice.Soil stickiness, soil organic matter content is medium, and pH 7.1, the equal normal management of wheat before and after the test, wheat was gathered in the crops June 15.
Test medicine and dosage are: 70% SYP-3375 thiophanate-methyl water dispersible granules 40g/667 ㎡, 35g/667 ㎡, 30g/667 ㎡; 50% SYP-3375 carbendazim suspending agent 45g/667 ㎡, 35g/667 ㎡, 25g/667 ㎡; 40% SYP-3375 benomyl suspending agent 25g/667 ㎡, 20g/667 ㎡, 15g/667 ㎡; 20% SYP-3375 suspending agent 25g/667 ㎡; 50% thiophanate-methyl suspending agent 150g/667 ㎡; 50% carbendazol wettable powder 125g/667 ㎡, 50% benomyl wetting powder 100g/667 ㎡.Other establishes blank, and every processing 4 times repeats, every sub-district area 33.3 ㎡, and totally 64 sub-districts, district's group is arranged at random.Adopt conventional spray-on process, mu dispenser liquid 50 kg.The same manner dispenser 1 time is again adopted in Sheng phase wheat flowering beginning (April 28) beginning dispenser for the first time at interval behind the 7d.
Investigation and statistical method, each sub-district disease index of 14d investigation adopts 5 sampling modes after the 2nd dispenser, and every some 5O fringe calculates disease tassel yield, disease index and control efficiency respectively.
Disease index is pressed following mode classification:
1 grade: sick small ear is less than total fringe 1/4;
2 grades: sick small ear accounts for total fringe 1/4～1/2;
3 grades: sick small ear accounts for total fringe 1/2～3/4;
4 grades: sick small ear accounts for total fringe and works energetically 3/4.
The disease index computational methods:
Disease tassel yield=sick spike number/investigate total spike number * 100%
Disease index=Σ (sick spike numbers at different levels * relative level numerical value)/investigate total spike number * 4 * 100%
Disease index * 100% after control efficiency (%)=(disease index after disease index after the dispenser of blank district-chemicals treatment district dispenser)/blank district dispenser.
Field test results shows: 70% SYP-3375 thiophanate-methyl water dispersible granules 40g/667 ㎡; 35g/667 ㎡ is 88.65% and 83.41% to the wheat scab preventive effect; 50% SYP-3375 carbendazim suspending agent 45g/667 ㎡; 35g/667 ㎡ is 89.44% and 84.18% to the wheat scab preventive effect; 40% SYP-3375 benomyl suspending agent 25g/667 ㎡; 20g/667 ㎡ is 90.11% and 84.88% to the wheat scab preventive effect, obviously is better than 20% SYP-3375 suspending agent 25g/667 ㎡ (79.87%); 50% thiophanate-methyl suspending agent 150g/667 ㎡ (74.26%); 50% carbendazol wettable powder 125g/667 ㎡ (75.95%); 50% benomyl wetting powder 100g/667 ㎡ (78.47%) is to the preventive effect of wheat scab.Duration of test is observed, and each chemicals treatment does not produce the poisoning phenomenon to wheat.
Result of the test has obviously improved the control efficiency to wheat scab after showing that SYP-3375 and thiophanate-methyl, carbendazim, benomyl are mixed, and has reduced dosage and drug cost, to wheat growth safety, is the desirable medicament of preventing and treating wheat scab.
In sum; Composition of the present invention is to adopt two kinds of active component compound schemes; Its activity and bactericidal effect are not the simple superposition of each composition activity, compare with existing single preparation, except that having significant bactericidal effect; And significant synergistic effect arranged; Slow down the generation of resistance, the preparation less residue, pollution-free to crop; Safety is good, meets the security requirement of pesticidal preparations.
Claims (8)
1. bactericidal composition that contains SYP-3375 and benzimidazole germicide is characterized in that comprising:
A) the first active component SYP-3375;
B) second active component is a benzimidazole germicide, is selected from a kind of in thiophanate-methyl, carbendazim, the benomyl;
The weight ratio of first active component and second active component is 1:1～1:50.
2. according to the said bactericidal composition that contains SYP-3375 and benzimidazole germicide of claim 1, it is characterized in that: the weight ratio of first active component and second active component is 1:1～1:30.
3. according to the said bactericidal composition that contains SYP-3375 and benzimidazole germicide of claim 2, it is characterized in that: the weight ratio of first active component and second active component is 1:2～1:30.
4. according to one of any said bactericidal composition that contains SYP-3375 and benzimidazole germicide of claim 1 to 3, it is characterized in that: the cumulant of first active component and second active component is 5%～90% of a said composition total weight.
5. according to the said bactericidal composition that contains SYP-3375 and benzimidazole germicide of claim 4, it is characterized in that: the cumulant of first active component and second active component is 10%～60% of a said composition total weight.
6. according to the said bactericidal composition that contains SYP-3375 and benzimidazole germicide of claim 1, it is characterized in that: said composition can be mixed with agricultural and go up any formulation that allows.
7. according to the said bactericidal composition that contains SYP-3375 and benzimidazole germicide of claim 6, it is characterized in that: said composition is water dispersible granules, wetting powder or suspending agent.
8. according to the said purposes of bactericidal composition in preventing and treating ring rot of apple, anthracnose, rot, rice sheath blight disease, rice blast, wheat scab that contains SYP-3375 and benzimidazole germicide of claim 1.
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| CN103053572A (en) * | 2012-09-21 | 2013-04-24 | 吉林省八达农药有限公司 | Agricultural antifungal composition containing coumoxystrobin and thiophanate-methyl |
| CN105165856A (en) * | 2015-10-26 | 2015-12-23 | 广西南宁益土生物科技有限责任公司 | Bactericide containing carbendazim and cinnamaldehyde |
| CN110495461A (en) * | 2018-05-19 | 2019-11-26 | 安徽省农业科学院植物保护与农产品质量安全研究所 | A kind of bactericidal composition containing coumoxystrobin and probenazole |
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| CN1915019A (en) * | 2005-08-17 | 2007-02-21 | 浙江化工科技集团有限公司 | Composition of bactericide |
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Cited By (3)
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| CN103053572A (en) * | 2012-09-21 | 2013-04-24 | 吉林省八达农药有限公司 | Agricultural antifungal composition containing coumoxystrobin and thiophanate-methyl |
| CN105165856A (en) * | 2015-10-26 | 2015-12-23 | 广西南宁益土生物科技有限责任公司 | Bactericide containing carbendazim and cinnamaldehyde |
| CN110495461A (en) * | 2018-05-19 | 2019-11-26 | 安徽省农业科学院植物保护与农产品质量安全研究所 | A kind of bactericidal composition containing coumoxystrobin and probenazole |
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