CN102603740B - Synthetic method of 4-nitro-7-azaindole - Google Patents
Synthetic method of 4-nitro-7-azaindole Download PDFInfo
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- CN102603740B CN102603740B CN201210051382.1A CN201210051382A CN102603740B CN 102603740 B CN102603740 B CN 102603740B CN 201210051382 A CN201210051382 A CN 201210051382A CN 102603740 B CN102603740 B CN 102603740B
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Abstract
The invention relates to the field of synthesis of medicament intermediates, in particular to a synthetic method of 4-nitro-7-azaindole. A preparation method disclosed by the invention is characterized by comprising the following steps of: I, reacting 1H-pyrrolo[2,3-b]pyridine-3-carbosylate serving as a raw material with m-chloroperoxybenzoic acid to obtain a compound VII; II, undergoing a nitration reaction to obtain a compound VIII; III, performing decarboxylation under the condition of dilute sulfuric acid to obtain a compound IV; and IV, removing an N-oxide under the action of PCl3 to obtain a compound I. The preparation method disclosed by the invention has the advantages of mild reaction conditions, high yield in each step, easiness for post-treatment, easiness for operating and suitability for industrial mass production.
Description
Technical field
The present invention relates to the synthetic field of pharmaceutical intermediate, be specifically related to the synthetic method of 4-nitro-7-azaindole.
Background technology
4-nitro-7-azaindole is a kind of very useful pharmaceutical intermediate.Be applied to recently in synthetic nucleosides compounds, the nucleosides in nucleic acid is formed with ribose or ribodesose condensation by (N1) of 4-nitro-7-azaindole or 4-amino-7-azaindole.Novel nucleoside compound has antiviral activity, for the preparation of antiviral, so 4-nitro-7-azaindole will be very crucial intermediate.
For the preparation of 4-nitro-7-azaindole, bibliographical information related compound method is as follows:
Method is by J.Med.Chem.1982,25,1258-1261 report,
Reagent and productive rate: (a) metachloroperbenzoic acid (m-CPBA), methylene dichloride (DCM), 60%; (b) trifluoroacetic acid (TFA), nitrosonitric acid, 60%; (c) phosphorus trichloride, ethyl acetate, 80%.
The synthetic method of this report has the following disadvantages: intermediate compound IV does not possess the feasibility of extensive preparation because existing isomer V to be difficult to the shortcomings such as separation and purification, overall yield be low.
Summary of the invention
The object of this invention is to provide a kind of efficient, synthetic method of possessing 4-nitro-7-azaindole that extensive preparation is worth.Mainly solve that existing 4-nitro-7-azaindole yield is low, intermediate is difficult to purifying, cannot scale operation etc. technical problem.
Preparation method of the present invention, reacts with metachloroperbenzoic acid and obtains compound VI I for raw material with 1H-pyrrolo-[2,3-b] pyridine-3-carboxylic acid methyl esters; Second step obtains compound VI II through nitration reaction; The 3rd one-step hydrolysis decarboxylation obtains compound IV; The 4th step is at PCl
3under effect, de-N-oxide compound, obtains Compound I.
Reaction formula is as follows:
Wherein reaction conditions: d: oxidation; E: nitrated; F: hydrolysis decarboxylation; G: with PCl
3reaction.
The preferred metachloroperbenzoic acid of oxidation step oxygenant used.Temperature of reaction can be carried out at normal temperatures, preferably 0～30 ℃.
Nitration reaction is preferably under nitration mixture condition, to carry out, preferably 65～90 ℃ of temperature of reaction.
Described nitration mixture preferably in the vitriol oil or trifluoroacetic acid a kind of be selected from a kind of mixture in concentrated nitric acid or nitrosonitric acid.Wherein compound VI I: the mol ratio of concentrated nitric acid or nitrosonitric acid is 1: 2～1: 7.
In hydrolysis decarboxylation step, preferably add dilute sulphuric acid or concentrated hydrochloric acid.The concentration of dilute sulphuric acid preferably 10%～50%, is weight percentage.Compound VI II: the mol ratio of dilute sulphuric acid or concentrated hydrochloric acid is 1: 4～1: 7.Preferably 70～100 ℃ of hydrolysis decarboxylation temperature of reaction.
G step reaction temperature room temperature, also can be 0～74 ℃, preferably 10～30 ℃.
Preparation method's reaction conditions of the present invention is gentleer, and every step productive rate is all higher, and total recovery can reach 60% left and right.And aftertreatment is simple, easy to operate, be applicable to industrialized production.
Embodiment
Embodiment 1
Compound VI I's is synthetic
In 25L reaction flask, add compound VI 1100g (6.25mol, 1.0eq), 15L EA, lower the temperature 0 ℃, add 2000g m-CPBA (8.11mol, 1.30eq), stirred overnight at room temperature in batches, LC-MS monitoring reacts completely, filter, EA washing obtains compound VI I 1100g, yield 91%.
1H?NMR(400MHz，DMSO-d6)：8.21(d，1H)，8.12(s，1H)，7.92(d，1H)，7.22(d，1H)，3.82(s，1H)。
Compound VI II's is synthetic
10L four-hole bottle, adds compound VI I 550g (2.86mol, 1.0eq), vitriol oil 1.5L, and 70-80 ℃ of reaction 1.5h of concentrated nitric acid 1L heating, after reacting completely, reaction solution is poured in frozen water, separates out a large amount of solids, filters, and directly carries out next step.
1HNMR?(400MHz，DMSO-d6)：8.41(d，1H)，8.30(s，1H)，7.85(d，1H)，3.57(s，3H)。
Synthesizing of compound IV
10L four-hole bottle, adds compound VI II 600g (2.53mol, 1.0eq), dilute sulphuric acid 5L, reflux, venting in a large number in heat-processed, produce yellow solid, entirely molten after backflow, after back flow reaction 3h, react completely, reaction solution is cooled to-10 ℃, ammoniacal liquor regulates PH to 4 left and right, separates out a large amount of yellow solids, and filtering drying obtains compound IV yellow solid 374g.Two step yields: 73.2%.
1H?NMR(400MHz，DMSO-d6)：8.31(d，1H)，8.03(d，1H)，7.82(d，1H)，7.04(d，1H)。
Synthesizing of Compound I
10L four-hole bottle, adds EA 5L, and compound IV 720g (4.019mol, 1.0eq) stirs, and solid can not be entirely molten, and frozen water is cooled to 0 ℃, drips PCl
3(1269g, 9.24mol, 2.3eq.), adds rear stirring 30min, is warming up to 25 ℃ and stirs 2h, reacts completely.Reaction solution is flutterred in ice, stirs, and separates out a large amount of solids, and strong aqua adjusts PH to be greater than 4, filters, and filter cake is dried and obtained glassy yellow solid 576.5g, yield: 88%, and purity: 99%.
1H?NMR(400MHz，DMSO-d)：12.58(s，1H)，8.51(d，1H)，7.96(dd，1H)，7.91(d，1H)，7.00(s，1H)。
Claims (6)
1. a preparation method for compound (I), comprising:
Wherein reaction conditions: d: oxidation; E: nitrated; F: hydrolysis decarboxylation; G: with PCl
3reaction,
Wherein nitration reaction is to carry out under nitration mixture condition, 65～90 ℃ of temperature of reaction, described nitration mixture be selected from the vitriol oil or trifluoroacetic acid a kind of be selected from a kind of mixture in concentrated nitric acid or nitrosonitric acid, and compound VI I: the mol ratio of concentrated nitric acid or nitrosonitric acid is 1: 2～1: 7.
2. the preparation method of claim 1, wherein oxidation step oxygenant used is metachloroperbenzoic acid.
3. the preparation method of claim 1, wherein hydrolysis decarboxylation step adds dilute sulphuric acid or concentrated hydrochloric acid.
4. the preparation method of claim 3, wherein the concentration of dilute sulphuric acid is 10%～50%, is weight percentage.
5. the preparation method of claim 3, wherein compound VI II: the mol ratio of dilute sulphuric acid or concentrated hydrochloric acid is 1: 4～1: 7.
6. the preparation method of claim 1, wherein hydrolysis decarboxylation temperature of reaction is 70～100 ℃.
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| CN105777747A (en) * | 2016-04-05 | 2016-07-20 | 叶芳 | 4-chloro-7-azaindole and preparation method thereof |
| CN109694343B (en) * | 2018-12-19 | 2020-07-28 | 帕潘纳(北京)科技有限公司 | Decarboxylation method of heterocyclic carboxylic acid compounds |
| CN112574095A (en) * | 2020-12-21 | 2021-03-30 | 常州大学 | Novel method for nitrifying isatin derivative |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004111048A1 (en) * | 2003-06-12 | 2004-12-23 | Sanofi-Aventis Deutschland Gmbh | 3-(guanidinocarbonyl)heterocycle derivatives, preparation process and intermediates of this process, their use as medicaments, and pharmaceutical compositions including them |
| WO2005058891A1 (en) * | 2003-12-09 | 2005-06-30 | Bayer Healthcare Ag | Pyrrolopyridine-substituted benzol derivatives for treating cardiovascular diseases |
| WO2005097790A1 (en) * | 2004-04-08 | 2005-10-20 | Bayer Healthcare Ag | Hetaryloxy-substituted phenylamino pyrimidines as rho kinase inhibitors |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004111048A1 (en) * | 2003-06-12 | 2004-12-23 | Sanofi-Aventis Deutschland Gmbh | 3-(guanidinocarbonyl)heterocycle derivatives, preparation process and intermediates of this process, their use as medicaments, and pharmaceutical compositions including them |
| WO2005058891A1 (en) * | 2003-12-09 | 2005-06-30 | Bayer Healthcare Ag | Pyrrolopyridine-substituted benzol derivatives for treating cardiovascular diseases |
| WO2005097790A1 (en) * | 2004-04-08 | 2005-10-20 | Bayer Healthcare Ag | Hetaryloxy-substituted phenylamino pyrimidines as rho kinase inhibitors |
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Address after: 210061 Nanjing high tech Industrial Development Zone, Jiangsu Province Road, No. 10 Patentee after: PHARMABLOCK (NANJING) R&D CO., LTD. Address before: 210061 Nanjing high tech Industrial Development Zone, Jiangsu Province Road, No. 10 Patentee before: Nanjing Medical Stone and Medicine Research and Development Co., Ltd. |