CN102600453B - 硫酸粘杆菌素预混剂制备方法 - Google Patents
硫酸粘杆菌素预混剂制备方法 Download PDFInfo
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- CN102600453B CN102600453B CN 201210075530 CN201210075530A CN102600453B CN 102600453 B CN102600453 B CN 102600453B CN 201210075530 CN201210075530 CN 201210075530 CN 201210075530 A CN201210075530 A CN 201210075530A CN 102600453 B CN102600453 B CN 102600453B
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- colistine sulfate
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- ZESIAEVDVPWEKB-ORCFLVBFSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(3s,6s,9s,12s,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-h Chemical compound OS(O)(=O)=O.OS(O)(=O)=O.CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O ZESIAEVDVPWEKB-ORCFLVBFSA-N 0.000 title abstract 4
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- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 44
- YKQOSKADJPQZHB-RGYSVOEGSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(6r,9s,12r,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydr Chemical compound CCC(C)CCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)C([C@@H](C)O)NC(=O)[C@@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O YKQOSKADJPQZHB-RGYSVOEGSA-N 0.000 claims description 44
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- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 4
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- 229960003346 colistin Drugs 0.000 description 2
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- JORAUNFTUVJTNG-BSTBCYLQSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(3s,6s,9s,12s,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-h Chemical compound CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O JORAUNFTUVJTNG-BSTBCYLQSA-N 0.000 description 2
- XDJYMJULXQKGMM-UHFFFAOYSA-N polymyxin E1 Natural products CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O XDJYMJULXQKGMM-UHFFFAOYSA-N 0.000 description 2
- KNIWPHSUTGNZST-UHFFFAOYSA-N polymyxin E2 Natural products CC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O KNIWPHSUTGNZST-UHFFFAOYSA-N 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 241000588832 Bordetella pertussis Species 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 239000003674 animal food additive Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 238000009360 aquaculture Methods 0.000 description 1
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- 239000012752 auxiliary agent Substances 0.000 description 1
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- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
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CN 201210075530 CN102600453B (zh) | 2012-03-21 | 2012-03-21 | 硫酸粘杆菌素预混剂制备方法 |
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CN102600453A CN102600453A (zh) | 2012-07-25 |
CN102600453B true CN102600453B (zh) | 2013-09-18 |
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Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103641893B (zh) * | 2013-11-18 | 2016-08-24 | 宁夏泰瑞制药股份有限公司 | 一种从硫酸粘杆菌素菌渣中回收硫酸粘杆菌素的方法 |
CN104397361A (zh) * | 2014-12-12 | 2015-03-11 | 无锡正大畜禽有限公司 | 一种饲料用纳米级硫酸粘杆菌素预混剂的制备方法 |
CN106039283A (zh) * | 2016-08-24 | 2016-10-26 | 浙江升华拜克生物股份有限公司 | 一种硫酸粘杆菌素预混剂的制备方法 |
CN108432949B (zh) * | 2018-03-13 | 2021-06-18 | 河北圣雪大成制药有限责任公司 | 一种节能环保的土霉素钙的生产设备及制备方法 |
CN112005904A (zh) * | 2020-08-25 | 2020-12-01 | 江西增鑫科技股份有限公司 | 一种乳化猪饲养***及其饲养方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1238673A1 (en) * | 1999-12-14 | 2002-09-11 | Asahi Kasei Kabushiki Kaisha | Colistin sulfate granules |
CN101869188A (zh) * | 2010-06-11 | 2010-10-27 | 濮阳泓天威药业有限公司 | 那西肽预混剂的制备方法 |
CN102258765A (zh) * | 2011-07-11 | 2011-11-30 | 浙江升华拜克生物股份有限公司 | 一种硫酸粘杆菌素预混剂的制备方法 |
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2012
- 2012-03-21 CN CN 201210075530 patent/CN102600453B/zh not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1238673A1 (en) * | 1999-12-14 | 2002-09-11 | Asahi Kasei Kabushiki Kaisha | Colistin sulfate granules |
CN101869188A (zh) * | 2010-06-11 | 2010-10-27 | 濮阳泓天威药业有限公司 | 那西肽预混剂的制备方法 |
CN102258765A (zh) * | 2011-07-11 | 2011-11-30 | 浙江升华拜克生物股份有限公司 | 一种硫酸粘杆菌素预混剂的制备方法 |
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Effective date of registration: 20190115 Address after: 310000 Room F, 9/F, Building A, Paradise Software Park, No. 3 Xidoumen Road, Xihu District, Hangzhou City, Zhejiang Province Patentee after: ZHEJIANG ZHEJIANG UNIVERSITY SUNSHINE TECHNOLOGY CO.,LTD. Address before: 226005 No. 98 Yuejiang Road, Nantong City, Jiangsu Province Patentee before: JIANGSU SEL BIOCHEMISTRY Co.,Ltd. |
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Effective date of registration: 20210825 Address after: 310000 block a, 9 / F, building a, Paradise Software Park, No. 3, xidoumen Road, Xihu District, Hangzhou City, Zhejiang Province Patentee after: Hangzhou Shangni Biotechnology Co.,Ltd. Address before: 310000 Room F, 9/F, Building A, Paradise Software Park, No. 3 Xidoumen Road, Xihu District, Hangzhou City, Zhejiang Province Patentee before: ZHEJIANG ZHEJIANG UNIVERSITY SUNSHINE TECHNOLOGY Co.,Ltd. |
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Effective date of registration: 20211108 Address after: 226000 Building 2, No. 128, Changhe Road, Nantong, Jiangsu Province Patentee after: JIANGSU SEL BIOCHEMISTRY Co.,Ltd. Address before: 310000 block a, 9 / F, building a, Paradise Software Park, No. 3, xidoumen Road, Xihu District, Hangzhou City, Zhejiang Province Patentee before: Hangzhou Shangni Biotechnology Co.,Ltd. |
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Granted publication date: 20130918 |