CN101869188A - 那西肽预混剂的制备方法 - Google Patents
那西肽预混剂的制备方法 Download PDFInfo
- Publication number
- CN101869188A CN101869188A CN201010198227A CN201010198227A CN101869188A CN 101869188 A CN101869188 A CN 101869188A CN 201010198227 A CN201010198227 A CN 201010198227A CN 201010198227 A CN201010198227 A CN 201010198227A CN 101869188 A CN101869188 A CN 101869188A
- Authority
- CN
- China
- Prior art keywords
- nosiheptide
- western peptide
- preparation
- mycelium
- western
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- FPTCMHOCGKKRGQ-WYOWUDGCSA-N Multhiomycin Natural products CC=C1NC(=O)[C@@H](NC(=O)c2csc(n2)c3cc(O)c(nc3c4csc(n4)[C@H]5CSC(=O)c6[nH]c7cccc(COC(=O)[C@@H](O)C[C@H](NC(=O)c8csc1n8)c9nc(cs9)C(=O)N5)c7c6C)c%10nc(cs%10)C(=O)N[C@@H](C)C(=O)N)[C@H](C)O FPTCMHOCGKKRGQ-WYOWUDGCSA-N 0.000 title claims abstract description 80
- 101800003864 Nosiheptide Proteins 0.000 title claims abstract description 80
- 229950006423 nosiheptide Drugs 0.000 title claims abstract description 80
- 238000002360 preparation method Methods 0.000 title claims abstract description 47
- MQWDKYHFGBWGQZ-JQTJYXGUSA-N nosiheptide Chemical compound N([C@H](C(=O)N\C(C=1SC=C(N=1)C(=O)N[C@@H]1CC(O)C(=O)OCC=2C=CC=C3NC(=C(C3=2)C)C(=O)SC[C@H](NC(=O)C=2N=C1SC=2)C=1SC=C(N=1)C1=N2)=C/C)[C@@H](C)O)C(=O)C(N=3)=CSC=3C1=CC(=O)\C2=C1/NC(C(=O)NC(=C)C(N)=O)=CS1 MQWDKYHFGBWGQZ-JQTJYXGUSA-N 0.000 title claims abstract 30
- 239000000843 powder Substances 0.000 claims abstract description 73
- 239000000047 product Substances 0.000 claims abstract description 51
- 238000001035 drying Methods 0.000 claims abstract description 44
- 238000000855 fermentation Methods 0.000 claims abstract description 17
- 230000004151 fermentation Effects 0.000 claims abstract description 17
- 239000000853 adhesive Substances 0.000 claims abstract description 14
- 230000001070 adhesive effect Effects 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 238000002156 mixing Methods 0.000 claims abstract description 8
- 239000012065 filter cake Substances 0.000 claims abstract description 5
- 238000003756 stirring Methods 0.000 claims abstract description 4
- 238000005550 wet granulation Methods 0.000 claims abstract description 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 131
- 239000003795 chemical substances by application Substances 0.000 claims description 66
- 238000001914 filtration Methods 0.000 claims description 39
- 239000012530 fluid Substances 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 17
- 239000007788 liquid Substances 0.000 claims description 15
- 239000000463 material Substances 0.000 claims description 10
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 8
- 239000008187 granular material Substances 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 5
- 235000010627 Phaseolus vulgaris Nutrition 0.000 claims description 4
- 244000046052 Phaseolus vulgaris Species 0.000 claims description 4
- 229920002472 Starch Polymers 0.000 claims description 4
- 229910021536 Zeolite Inorganic materials 0.000 claims description 4
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical group [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 4
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 4
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 claims description 4
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 4
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 4
- 239000008107 starch Substances 0.000 claims description 4
- 235000019698 starch Nutrition 0.000 claims description 4
- 239000010457 zeolite Substances 0.000 claims description 4
- OBMZMSLWNNWEJA-XNCRXQDQSA-N C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 Chemical compound C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 OBMZMSLWNNWEJA-XNCRXQDQSA-N 0.000 claims description 3
- 229920000881 Modified starch Polymers 0.000 claims description 3
- 101710176384 Peptide 1 Proteins 0.000 claims description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 3
- 241001052560 Thallis Species 0.000 claims description 3
- 238000010564 aerobic fermentation Methods 0.000 claims description 3
- 230000001580 bacterial effect Effects 0.000 claims description 3
- 238000007908 dry granulation Methods 0.000 claims description 3
- 239000006052 feed supplement Substances 0.000 claims description 3
- 238000010899 nucleation Methods 0.000 claims description 3
- 229920002401 polyacrylamide Polymers 0.000 claims description 3
- 210000004243 sweat Anatomy 0.000 claims description 3
- 238000002255 vaccination Methods 0.000 claims description 3
- 240000008042 Zea mays Species 0.000 claims description 2
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims description 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 2
- 235000005822 corn Nutrition 0.000 claims description 2
- 235000013312 flour Nutrition 0.000 claims description 2
- 238000007873 sieving Methods 0.000 claims description 2
- 235000015099 wheat brans Nutrition 0.000 claims description 2
- 230000008901 benefit Effects 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 239000003960 organic solvent Substances 0.000 abstract description 4
- 238000003825 pressing Methods 0.000 abstract 2
- 239000008394 flocculating agent Substances 0.000 abstract 1
- OQAOHXRUMXWDLQ-ATVZKCIHSA-N N-(3-amino-3-oxoprop-1-en-2-yl)-2-[(1S,18S,21Z,28S,30S)-21-ethylidene-9,30-dihydroxy-18-[(1R)-1-hydroxyethyl]-40-methyl-16,19,26,31,42,46-hexaoxo-32-oxa-3,13,23,43,49-pentathia-7,17,20,27,45,51,52,53,54,55-decazanonacyclo[26.16.6.12,5.112,15.122,25.138,41.147,50.06,11.034,39]pentapentaconta-2(55),4,6,8,10,12(54),14,22(53),24,34(39),35,37,40,47,50-pentadecaen-8-yl]-1,3-thiazole-4-carboxamide Chemical compound C\C=C1/NC(=O)[C@@H](NC(=O)c2csc(n2)-c2cc(O)c(nc2-c2csc(n2)[C@@H]2CSC(=O)c3[nH]c4cccc(COC(=O)[C@@H](O)C[C@H](NC(=O)c5csc1n5)c1nc(cs1)C(=O)N2)c4c3C)-c1nc(cs1)C(=O)NC(=C)C(N)=O)[C@@H](C)O OQAOHXRUMXWDLQ-ATVZKCIHSA-N 0.000 description 51
- 230000003115 biocidal effect Effects 0.000 description 11
- 229910052751 metal Inorganic materials 0.000 description 7
- 239000002184 metal Substances 0.000 description 7
- 239000002245 particle Substances 0.000 description 7
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical class [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 6
- 244000005700 microbiome Species 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 238000005469 granulation Methods 0.000 description 5
- 230000003179 granulation Effects 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 230000004888 barrier function Effects 0.000 description 4
- 239000000706 filtrate Substances 0.000 description 4
- 238000005265 energy consumption Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000001238 wet grinding Methods 0.000 description 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
- 241000192125 Firmicutes Species 0.000 description 2
- NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000010534 mechanism of action Effects 0.000 description 2
- YKQOSKADJPQZHB-RGYSVOEGSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(6r,9s,12r,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydr Chemical compound CCC(C)CCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)C([C@@H](C)O)NC(=O)[C@@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O YKQOSKADJPQZHB-RGYSVOEGSA-N 0.000 description 2
- 238000004062 sedimentation Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000001694 spray drying Methods 0.000 description 2
- 239000000273 veterinary drug Substances 0.000 description 2
- RPABDKTXMKOGKI-OYTUFZPASA-N 6-methyl-n-[2-[(2s,5s,8s,11s,14s,17s,20s,23s)-8,11,14,20-tetrakis(2-aminoethyl)-5-[(1r)-1-hydroxyethyl]-17,23-bis(2-methylpropyl)-3,6,9,12,15,18,21,24-octaoxo-1,4,7,10,13,16,19,22-octazacyclotetracos-2-yl]ethyl]octanamide Chemical compound CCC(C)CCCCC(=O)NCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H]([C@@H](C)O)NC1=O RPABDKTXMKOGKI-OYTUFZPASA-N 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 108010078777 Colistin Proteins 0.000 description 1
- MIKUYHXYGGJMLM-GIMIYPNGSA-N Crotonoside Natural products C1=NC2=C(N)NC(=O)N=C2N1[C@H]1O[C@@H](CO)[C@H](O)[C@@H]1O MIKUYHXYGGJMLM-GIMIYPNGSA-N 0.000 description 1
- NYHBQMYGNKIUIF-UHFFFAOYSA-N D-guanosine Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(CO)C(O)C1O NYHBQMYGNKIUIF-UHFFFAOYSA-N 0.000 description 1
- 102000008153 Peptide Elongation Factor Tu Human genes 0.000 description 1
- 108010049977 Peptide Elongation Factor Tu Proteins 0.000 description 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 1
- 241000187762 Streptomyces actuosus Species 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000003674 animal food additive Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000000701 coagulant Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229940029575 guanosine Drugs 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 229920000620 organic polymer Polymers 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 239000003910 polypeptide antibiotic agent Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
Landscapes
- Peptides Or Proteins (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2010101982273A CN101869188B (zh) | 2010-06-11 | 2010-06-11 | 那西肽预混剂的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2010101982273A CN101869188B (zh) | 2010-06-11 | 2010-06-11 | 那西肽预混剂的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101869188A true CN101869188A (zh) | 2010-10-27 |
CN101869188B CN101869188B (zh) | 2011-06-08 |
Family
ID=42994418
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2010101982273A Active CN101869188B (zh) | 2010-06-11 | 2010-06-11 | 那西肽预混剂的制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN101869188B (zh) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102210630A (zh) * | 2011-06-02 | 2011-10-12 | 浙江汇能动物药品有限公司 | 一种制备那西肽预混剂颗粒的***及方法 |
CN102258765A (zh) * | 2011-07-11 | 2011-11-30 | 浙江升华拜克生物股份有限公司 | 一种硫酸粘杆菌素预混剂的制备方法 |
CN102600453A (zh) * | 2012-03-21 | 2012-07-25 | 江苏赛奥生化有限公司 | 硫酸粘杆菌素预混剂制备方法 |
CN104351483A (zh) * | 2014-11-13 | 2015-02-18 | 河北圣雪大成制药有限责任公司 | 一种全发酵土霉素钙颗粒剂的制备方法 |
CN104367989A (zh) * | 2014-10-21 | 2015-02-25 | 河南牧翔动物药业有限公司 | 一种水包油型硫酸新霉素、那西肽纳米乳抗菌药物 |
CN104621360A (zh) * | 2015-03-11 | 2015-05-20 | 河北圣雪大成制药有限责任公司 | 一种杆菌肽锌预混剂的制备方法 |
CN104719634A (zh) * | 2015-02-10 | 2015-06-24 | 河北圣雪大成制药有限责任公司 | 一种制备那西肽预混剂的方法 |
CN105198958A (zh) * | 2015-09-29 | 2015-12-30 | 浙江汇能动物药品有限公司 | 一种那西肽精粉的提取方法 |
CN108440557A (zh) * | 2018-03-30 | 2018-08-24 | 内蒙古拜克生物有限公司 | 一种盐霉素发酵液的预处理方法 |
CN110575532A (zh) * | 2018-06-08 | 2019-12-17 | 上海莫息生物科技有限公司 | 一种那西肽可溶性粉及其制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1899599A (zh) * | 2005-07-19 | 2007-01-24 | 复旦大学 | 一种制备那西肽预混剂的方法 |
CN101302247A (zh) * | 2008-06-24 | 2008-11-12 | 浙江汇能动物药品有限公司 | 一种提取那西肽粗品的方法 |
CN101624418A (zh) * | 2009-08-03 | 2010-01-13 | 安徽省皖北药业股份有限公司 | 那西肽粉的制备方法 |
-
2010
- 2010-06-11 CN CN2010101982273A patent/CN101869188B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1899599A (zh) * | 2005-07-19 | 2007-01-24 | 复旦大学 | 一种制备那西肽预混剂的方法 |
CN101302247A (zh) * | 2008-06-24 | 2008-11-12 | 浙江汇能动物药品有限公司 | 一种提取那西肽粗品的方法 |
CN101624418A (zh) * | 2009-08-03 | 2010-01-13 | 安徽省皖北药业股份有限公司 | 那西肽粉的制备方法 |
Non-Patent Citations (2)
Title |
---|
《养猪》 20091031 杨帆 新型饲料添加剂那西肽在养猪生产中的应用 9-11 1-10 , 第5期 2 * |
《药物生物技术》 20041231 韩果红等 兽用抗生素诺西肽(nosiheptide)的研究进展 406-409 1-10 , 第6期 2 * |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102210630B (zh) * | 2011-06-02 | 2014-01-15 | 浙江汇能动物药品有限公司 | 一种制备那西肽预混剂颗粒的***及方法 |
CN102210630A (zh) * | 2011-06-02 | 2011-10-12 | 浙江汇能动物药品有限公司 | 一种制备那西肽预混剂颗粒的***及方法 |
CN102258765A (zh) * | 2011-07-11 | 2011-11-30 | 浙江升华拜克生物股份有限公司 | 一种硫酸粘杆菌素预混剂的制备方法 |
CN102258765B (zh) * | 2011-07-11 | 2013-09-04 | 浙江升华拜克生物股份有限公司 | 一种硫酸粘杆菌素预混剂的制备方法 |
CN102600453A (zh) * | 2012-03-21 | 2012-07-25 | 江苏赛奥生化有限公司 | 硫酸粘杆菌素预混剂制备方法 |
CN102600453B (zh) * | 2012-03-21 | 2013-09-18 | 江苏赛奥生化有限公司 | 硫酸粘杆菌素预混剂制备方法 |
CN104367989A (zh) * | 2014-10-21 | 2015-02-25 | 河南牧翔动物药业有限公司 | 一种水包油型硫酸新霉素、那西肽纳米乳抗菌药物 |
CN104351483A (zh) * | 2014-11-13 | 2015-02-18 | 河北圣雪大成制药有限责任公司 | 一种全发酵土霉素钙颗粒剂的制备方法 |
CN104719634A (zh) * | 2015-02-10 | 2015-06-24 | 河北圣雪大成制药有限责任公司 | 一种制备那西肽预混剂的方法 |
CN104719634B (zh) * | 2015-02-10 | 2018-08-24 | 河北圣雪大成制药有限责任公司 | 一种制备那西肽预混剂的方法 |
CN104621360A (zh) * | 2015-03-11 | 2015-05-20 | 河北圣雪大成制药有限责任公司 | 一种杆菌肽锌预混剂的制备方法 |
CN105198958A (zh) * | 2015-09-29 | 2015-12-30 | 浙江汇能动物药品有限公司 | 一种那西肽精粉的提取方法 |
CN108440557A (zh) * | 2018-03-30 | 2018-08-24 | 内蒙古拜克生物有限公司 | 一种盐霉素发酵液的预处理方法 |
CN108440557B (zh) * | 2018-03-30 | 2019-03-15 | 内蒙古拜克生物有限公司 | 一种盐霉素发酵液的预处理方法 |
CN110575532A (zh) * | 2018-06-08 | 2019-12-17 | 上海莫息生物科技有限公司 | 一种那西肽可溶性粉及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN101869188B (zh) | 2011-06-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101869188B (zh) | 那西肽预混剂的制备方法 | |
CN101880202B (zh) | 一种用于提高农牧业产量的添加剂 | |
CN103980040B (zh) | 一种双藻寡糖颗粒肥及其制备方法 | |
CN101862443B (zh) | 恩拉霉素预混剂的制备方法 | |
CN104757273B (zh) | 一种制备颗粒型苏氨酸产品的工艺 | |
CN101508605B (zh) | 生物有机肥料及其制备方法 | |
CN103073363B (zh) | 一种活性全营养多维配方有机肥料及其制造方法 | |
CN103772038A (zh) | 一种天然海藻有机肥的生产方法 | |
CN106578702B (zh) | 一种鱼饲料的制备方法 | |
CN104151023A (zh) | 一种菌剂发酵型有机肥料及其制备方法 | |
CN103708973A (zh) | 一种土壤修复活性有机肥的制备方法及其产品和应用 | |
CN101879142B (zh) | 马度米星铵预混剂的制备方法 | |
CN112568241A (zh) | 一种杀虫颗粒剂及其制备工艺 | |
CN107555612A (zh) | 一种水产养殖环境专用净化剂及其制备工艺 | |
CN108543060B (zh) | 一种提高恩拉霉素预混剂稳定性的方法 | |
CN113372171A (zh) | 用于玉米的全元生物有机肥及其制备方法 | |
CN104543413B (zh) | 一种阿维拉霉素预混剂的制备方法 | |
CN105995224A (zh) | 一种多功能水产养殖水体改良剂的制备方法 | |
CN113057258B (zh) | 一种环保有机猪饲料及其制备方法 | |
CN107197708A (zh) | 一种海藻发酵复合改性硫酸盐有机营养土的制备方法 | |
CN101253931A (zh) | 一种复合抗结块剂及其制备方法 | |
CN113841815A (zh) | 一种浮性发酵软颗粒饲料养殖扣蟹的方法 | |
CN113773143A (zh) | 芒果专用微生物缓释复合肥及其制备方法 | |
CN105124249A (zh) | 一种可自降解的水产混养饲料及其制备方法 | |
CN105348018A (zh) | 一种水稻专用酵素有机复混肥及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Preparation of nasiheptide premix Effective date of registration: 20210308 Granted publication date: 20110608 Pledgee: Puyang branch of Bank of Zhengzhou Co.,Ltd. Pledgor: PUYANG HOTWAY PHARMACEUTICALS Co.,Ltd. Registration number: Y2021980001498 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20220526 Granted publication date: 20110608 Pledgee: Puyang branch of Bank of Zhengzhou Co.,Ltd. Pledgor: PUYANG HOTWAY PHARMACEUTICALS Co.,Ltd. Registration number: Y2021980001498 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Preparation of nasitide premix Effective date of registration: 20220608 Granted publication date: 20110608 Pledgee: Postal Savings Bank of China Limited by Share Ltd. Puyang branch Pledgor: PUYANG HOTWAY PHARMACEUTICALS Co.,Ltd. Registration number: Y2022980007339 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20230512 Granted publication date: 20110608 Pledgee: Postal Savings Bank of China Limited by Share Ltd. Puyang branch Pledgor: PUYANG HOTWAY PHARMACEUTICALS Co.,Ltd. Registration number: Y2022980007339 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Preparation method of Naxi peptide premix Effective date of registration: 20230517 Granted publication date: 20110608 Pledgee: Postal Savings Bank of China Limited by Share Ltd. Puyang branch Pledgor: PUYANG HOTWAY PHARMACEUTICALS Co.,Ltd. Registration number: Y2023980040671 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Granted publication date: 20110608 Pledgee: Postal Savings Bank of China Limited by Share Ltd. Puyang branch Pledgor: PUYANG HOTWAY PHARMACEUTICALS Co.,Ltd. Registration number: Y2023980040671 |