CN102600049B - Medical unhairing spray and purpose of medical unhairing spray - Google Patents

Medical unhairing spray and purpose of medical unhairing spray Download PDF

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CN102600049B
CN102600049B CN201210076954.1A CN201210076954A CN102600049B CN 102600049 B CN102600049 B CN 102600049B CN 201210076954 A CN201210076954 A CN 201210076954A CN 102600049 B CN102600049 B CN 102600049B
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phase
spray
medical
depilation
skin
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CN102600049A (en
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徐克之
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Nanjing Yafang Pharmaceutical Co ltd
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Abstract

The invention discloses a medical unhairing spray. Through the medical unhairing spray provided by the invention, the existing and traditional skin preservation technology and products can be replaced, the unconventional traditional skin preservation can be fast, efficiently, safely and conveniently carried on operation receivers, the sterilization and the skin preservation succeed in one step, the infection rate of the skin preservation parts and the operation cuts is greatly reduced, and meanwhile, the operation risk is also reduced.

Description

Medical depilation spray and uses thereof
Technical field:
The present invention relates to medical depilation spray, belong to medicine, medical instruments field.
Background technology:
Preserved skin is exactly that the skin of operative region is carried out to chaeta removal, clean, sterilization, to guarantee to perform the operation, carries out smoothly and reduce postoperative infection.(because of a large amount of antibacterials in skin, hair, understand contamination of incision, cause postoperative infection, hair is not removed also can cause otch internal memory foreign body, cause infection of incisional wound, disunion).Preserved skin method can be divided into conventional traditional preserved skin and unconventional traditional preserved skin, and at present, what China adopted is conventional traditional razor preserved skin method, and its shortcoming is a lot, but because of without preserved skin substitute technology and product, so use till today always.
Figure BSA00000688252900011
Figure BSA00000688252900012
The shortcoming of conventional traditional preserved skin method:
1, razor preserved skin can cause skin histology damage, the visible trickle wound of skin histology, hyperemia, ooze out, redness, patient's pain is felt bad, but also can cause the infection of preserved skin position and operative incision, the infection rate of conventional traditional preserved skin is 5.6%, has greatly increased the risk of operation.
2, razor preserved skin complicated operation, time-consuming, take a lot of work, require great effort, particularly skinfold place has destroyed skin barrier, skin injury, wound infection rate is high; Department of obstetrics and gynecology, urology department, oxter preserved skin operate difficult.
According to < < Guideline For Prevention of Surgical Wound Infections > > (prevention of surgical wound infection guide) and U.S. peri-operation period registered nurse association (AORN) research report of the Center for Disease Control CDC, using the infection rate of the SSI of razor preserved skin is 5.6%, and use the SSI infection rate of depilatory preserved skin, be only 0.6%, so, Dispoable medical depilation spray preserved skin can reduce the infection rate of operative site greatly, also be unique method and the approach that reduces NIR.
Summary of the invention:
One aspect of the present invention relates to a kind of medical depilation spray, it is characterized in that the composition that contains following weight proportioning:
1. medical depilation spray, is characterized in that the composition that contains following weight proportioning: (%) formula: (%)
A phase (oil phase) B phase (water)
High viscosity white oil 2.0-5.0 carbamide 5.0-10.0
Silicone oil 1.0-4.0 sodium pyrosulfite 0.2-0.4
Emulsifying agent 4.0-8.0 60% potassium hydroxide solution 3.0-7.0
16-18 alcohol 4.0-8.0 carbomer Carbopol 934 0.1-0.3
Stearic acid 1.0-3.0 glycerol 3.0-7.0
Essence 0-0.4 propylene glycol 3.0-7.0
Methyl p-hydroxybenzoate 0.1-0.3 deionized water adds to 100
Ethyl hydroxybenzoate 0.5-1.0
C phase (chemical agent phase) D phase (biological agent phase)
Three hydration calcium mercaptoacetate 6.0-15.0 triclosan or quaternary ammonium salt 0.1-3
Calcium hydroxide 0.8-1.5 neutral red bisabolol 0.2-0.4
E phase (plant extract phase/skin protection phase)
Mentholum 0.1-0.3
Vitamin E 0.5-1.5
Aloe extraction solution 3.0-7.0
F phase (propellant)
Normal butane, iso-butane and/or n-propane 7-10 or Compressed Gas (nitrogen) 10-30 or dimethyl ether 20-25 or fluoric ether 7-15
In a preferred embodiment of the present invention, described emulsifying agent is A25.
In a preferred embodiment of the present invention, described depilatory agent is three hydration calcium mercaptoacetates.
In a preferred embodiment of the present invention, described propellant is normal butane, iso-butane and/or n-propane 7-10 or Compressed Gas (nitrogen) 10-30 or dimethyl ether 20-25 or fluoric ether 7-15.
In a preferred embodiment of the present invention, antibacterial is triclosan and quaternary ammonium salt derivative, complex (polyquaternary ammonium salt, organosilicon quaternary ammonium salt, bi-quaternary ammonium salt polysiloxanes 0.1% one 3%).
In a preferred embodiment of the present invention, anti-sensitizer is neutral red bisabolol 0.2%-0.4%.
In a preferred embodiment of the present invention, described medical depilation spray, is characterized in that the composition that contains following weight proportioning: (%)
A phase (oil phase) B phase (water)
High viscosity white oil 2.0-5.0 carbamide 5.0-10.0
Silicone oil 1.0-4.0 sodium pyrosulfite 0.2-0.4
Emulsifying agent 4.0-8.0 60% potassium hydroxide solution 3.0-7.0
16-18 alcohol 4.0-8.0 carbomer Carbopol 934 0.1-0.3
Stearic acid 1.0-3.0 glycerol 3.0-7.0
Essence 0-0.4 propylene glycol 3.0-7.0
Methyl p-hydroxybenzoate 0.1-0.3 deionized water adds to 100
Ethyl hydroxybenzoate 0.5-1.0
C phase (chemical agent phase) D phase (biological agent phase)
Three hydration calcium mercaptoacetate 6.0-15.0 triclosan or quaternary ammonium salt 0.1-3
Calcium hydroxide 0.8-1.5 neutral red bisabolol 0.2-0.4
E phase (plant extract phase/skin protection phase)
Mentholum 0.1-0.3
Vitamin E 0.5-1.5
Aloe extraction solution 3.0-7.0
F phase (propellant)
Normal butane, iso-butane and/or n-propane 7-10 or Compressed Gas (nitrogen) 10-30 or dimethyl ether 20-25 or fluoric ether 7-15
The preparation method of depilation spray of the present invention, comprises the steps: that A phase (oil phase) and B phase (water) are heated to respectively more than 80 ℃, then B phase (water) is slowly added in A phase (oil phase) to stirring, homogenizing; Add successively C phase (chemicals phase), D phase (medicine phase), E phase (plant extract phase/skin protection phase); Quantitative filling is to aluminium pot, and evacuation, is filled with F phase (propellant), sealing.
The present invention also relates to a kind of disposable depilation spray suit on the other hand, and it comprises the above-mentioned medical depilation spray of 25ml-100ml, disposable glove, a pasteurization towelette.
The invention still further relates to the application of above-mentioned medical depilation spray in operation preserved skin (depilation, sterilization).
The present invention can replace existing traditional preserved skin technology and product, it can be fast, effectively, safety, quickly patient is carried out to unconventional traditional preserved skin, sterilization, preserved skin be success once, greatly reduces the infection rate of preserved skin position and operative incision, has also reduced the risk of operation simultaneously.
The specific embodiment:
Formula: (%)
A phase (oil phase) B phase (water)
High viscosity white oil 2.0-5.0 carbamide 5.0-10.0
Silicone oil 1.0-4.0 sodium pyrosulfite 0.2-0.4
Emulsifying agent 4.0-8.0 60% potassium hydroxide solution 3.0-7.0
16-18 alcohol 4.0-8.0 carbomer Carbopol 934 0.1-0.3
Stearic acid 1.0-3.0 glycerol 3.0-7.0
Essence 0-0.4 propylene glycol 3.0-7.0
Methyl p-hydroxybenzoate 0.1-0.3 deionized water adds to 100
Ethyl hydroxybenzoate 0.5-1.0
C phase (chemical agent phase) D phase (biological agent phase)
Three hydration calcium mercaptoacetate 6.0-15.0 triclosan or quaternary ammonium salt 0.1-3
Calcium hydroxide 0.8-1.5 neutral red bisabolol 0.2-0.4
E phase (plant extract phase/skin protection phase)
Mentholum 0.1-0.3
Vitamin E 0.5-1.5
Aloe extraction solution 3.0-7.0
F phase (propellant)
Normal butane, iso-butane and/or n-propane 7-10 or Compressed Gas (nitrogen) 10-30 or dimethyl ether 20-25 or fluoric ether 7-15
Compound method: 1, A phase (oil phase) and B phase (water) are respectively heated to 85 ℃, then slowly adds B phase (water) in A phase (oil phase), stirring, homogenizing;
2, add successively C phase (chemicals phase), D phase (medicine phase), E phase (plant extract phase/skin protection phase);
3, quantitative filling is to aluminium pot, and evacuation, is filled with F phase (gas phase), sealing.
the unit of each composition is G, can be also KG, is the content of percentage ratio.Wherein A-F is mutually the order adding successively and purpose classification
Research group use Dispoable medical depilation spray preserved skin, routine shave mao preserved skin respectively (every group of 50 rats) 100 rats have been carried out to the experiment of animal preserved skin pain stimulation, preserved skin depilation experiment, preserved skin depilation hair growth experiment after ten days, preserved skin depilation position is back, Dispoable medical depilation spray using dosage is 8g, preserved skin area 5cm 2, be 8 minutes action time, experimental studies have found that:
Figure BSA00000688252900061
Figure BSA00000688252900071
Research group use Dispoable medical depilation spray preserved skin, routine shave mao preserved skin respectively (every group of 50 rats) 100 rats have been carried out to the experiment of animal preserved skin pain stimulation, preserved skin depilation experiment, preserved skin depilation hair growth experiment after ten days, preserved skin depilation position is back, Dispoable medical depilation spray using dosage is 8g, preserved skin area 5cm 2, be 8 minutes action time, experimental studies have found that:
Adopt medical depilation spray of the present invention, preserved skin position is without pain, and preserved skin position is thoroughly clean, does not stay dead angle, do not seal hair follicle, only rupture hair, depilation after hair follicle root of hair is had no adverse effects, depilation group grows new hair again after ten days, physiological function is normal.
Figure BSA00000688252900072
Should be understood that; the above-mentioned specific embodiment is only exemplary explanation, rather than limitation of the present invention, for those of ordinary skills; can be improved according to the above description or convert, and all these improvement and conversion all should belong to the protection domain of claims of the present invention.

Claims (5)

1. medical depilation spray, is characterized in that the composition that contains following weight proportioning %:
Formula:
Figure FSB0000114654420000011
C phase D phase
Three hydration calcium mercaptoacetate 6.0-15.0 triclosan or quaternary ammonium salt 0.1-3
Calcium hydroxide 0.8-1.5 neutral red bisabolol 0.2-0.4
Figure FSB0000114654420000012
F phase
Normal butane, iso-butane and/or n-propane 7-10 or compressed nitrogen 10-30 or dimethyl ether 20-25 or fluoric ether 7-15.
2. medical depilation spray, is characterized in that the composition that contains following weight proportioning %:
Formula:
Figure FSB0000114654420000021
C phase D phase
Three hydration calcium mercaptoacetate 6.0-15.0 triclosan or quaternary ammonium salt 0.1-3
Calcium hydroxide 0.8-1.5 neutral red bisabolol 0.2-0.4
F phase
Normal butane, iso-butane and/or n-propane 7-10 or compressed nitrogen 10-30 or dimethyl ether 20-25 or fluoric ether 7-15.
3. medical depilation spray according to claim 1 and 2, is characterized in that described emulsifying agent is A25.
4. Dispoable medical depilation spray is set with, and it comprises the medical depilation spray described in 25ml-100ml claim 1-3 any one, disposable glove, a pasteurization towelette.
5. the preparation method of the depilation spray described in claim 1 or 2, comprises the steps: that A phase and B are heated to respectively more than 80 ℃ mutually, then B is slowly added mutually A mutually in, stir, homogenizing; Add successively C phase, D phase, E phase; Quantitative filling is to aluminium pot, and evacuation, is filled with F phase, sealing.
CN201210076954.1A 2012-03-22 2012-03-22 Medical unhairing spray and purpose of medical unhairing spray Expired - Fee Related CN102600049B (en)

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CN102988236B (en) * 2012-11-30 2015-06-24 哈尔滨医科大学 Skin preparation solution used when head skin is prepared before neurosurgery operation and preparation method and application thereof
RU2657520C2 (en) * 2016-11-07 2018-06-14 Павел Александрович Громенко Cosmetic composition for removal of undesirable hair on the body of a person
CN114767563A (en) * 2022-05-09 2022-07-22 广州睿新生物科技有限公司 Mild and mild quick-acting depilatory composition and application thereof

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GB2415135A (en) * 2004-06-15 2005-12-21 Reckitt Benckiser Improvements in and relating to depilatory compositions
CN101756816A (en) * 2008-11-12 2010-06-30 曲磊 Calcium thioglycollate hair removal foam
GB0900582D0 (en) * 2009-01-15 2009-02-11 Reckitt & Colman Overseas Tropical composition
WO2011103233A1 (en) * 2010-02-17 2011-08-25 The Procter & Gamble Company Effective depilatory article
CN102058488A (en) * 2010-11-11 2011-05-18 广州市好迪化妆品有限公司 Low-pressure type propellant and application thereof
CN102166169A (en) * 2010-11-29 2011-08-31 吴克 Follicle shrinking and unhairing cream

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