CN102552871A - 一种鞣酸蛋白酵母咀嚼片及其生产方法 - Google Patents
一种鞣酸蛋白酵母咀嚼片及其生产方法 Download PDFInfo
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- CN102552871A CN102552871A CN2011104130443A CN201110413044A CN102552871A CN 102552871 A CN102552871 A CN 102552871A CN 2011104130443 A CN2011104130443 A CN 2011104130443A CN 201110413044 A CN201110413044 A CN 201110413044A CN 102552871 A CN102552871 A CN 102552871A
- Authority
- CN
- China
- Prior art keywords
- yeast
- tablet
- add
- tannalbin
- milk essence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 240000004808 Saccharomyces cerevisiae Species 0.000 title claims abstract description 32
- 239000007910 chewable tablet Substances 0.000 title claims abstract description 24
- 229940068682 chewable tablet Drugs 0.000 title claims abstract description 24
- 238000004519 manufacturing process Methods 0.000 title abstract description 7
- 229940043432 albumin tannate Drugs 0.000 title abstract 4
- NUJGJRNETVAIRJ-UHFFFAOYSA-N octanal Chemical compound CCCCCCCC=O NUJGJRNETVAIRJ-UHFFFAOYSA-N 0.000 title abstract 4
- 239000008267 milk Substances 0.000 claims abstract description 24
- 235000013336 milk Nutrition 0.000 claims abstract description 24
- 210000004080 milk Anatomy 0.000 claims abstract description 24
- 239000003826 tablet Substances 0.000 claims abstract description 23
- 239000000463 material Substances 0.000 claims abstract description 22
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 20
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims abstract description 15
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims abstract description 15
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims abstract description 15
- 238000000034 method Methods 0.000 claims abstract description 12
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 11
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims abstract description 10
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 7
- 229930006000 Sucrose Natural products 0.000 claims abstract description 7
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims abstract description 5
- 238000000576 coating method Methods 0.000 claims description 23
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- 239000007779 soft material Substances 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- 239000008213 purified water Substances 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 7
- 230000001476 alcoholic effect Effects 0.000 claims description 6
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- 230000009747 swallowing Effects 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 11
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- 230000000052 comparative effect Effects 0.000 description 9
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- 230000000694 effects Effects 0.000 description 5
- ZEMPKEQAKRGZGQ-AAKVHIHISA-N 2,3-bis[[(z)-12-hydroxyoctadec-9-enoyl]oxy]propyl (z)-12-hydroxyoctadec-9-enoate Chemical compound CCCCCCC(O)C\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CC(O)CCCCCC)COC(=O)CCCCCCC\C=C/CC(O)CCCCCC ZEMPKEQAKRGZGQ-AAKVHIHISA-N 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- 230000007774 longterm Effects 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 3
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- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 description 1
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- 206010014418 Electrolyte imbalance Diseases 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 239000001263 FEMA 3042 Substances 0.000 description 1
- 235000016623 Fragaria vesca Nutrition 0.000 description 1
- 240000009088 Fragaria x ananassa Species 0.000 description 1
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 1
- 208000019637 Infantile Diarrhea Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- XINCECQTMHSORG-UHFFFAOYSA-N Isoamyl isovalerate Chemical compound CC(C)CCOC(=O)CC(C)C XINCECQTMHSORG-UHFFFAOYSA-N 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
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- 235000018290 Musa x paradisiaca Nutrition 0.000 description 1
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 229910000323 aluminium silicate Inorganic materials 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 229910052797 bismuth Inorganic materials 0.000 description 1
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 208000019902 chronic diarrheal disease Diseases 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 230000000741 diarrhetic effect Effects 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000003223 protective agent Substances 0.000 description 1
- 230000006920 protein precipitation Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 235000000112 undernutrition Nutrition 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
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CN201110413044.3A CN102552871B (zh) | 2011-12-13 | 2011-12-13 | 一种鞣酸蛋白酵母咀嚼片及其生产方法 |
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CN201110413044.3A CN102552871B (zh) | 2011-12-13 | 2011-12-13 | 一种鞣酸蛋白酵母咀嚼片及其生产方法 |
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CN102552871A true CN102552871A (zh) | 2012-07-11 |
CN102552871B CN102552871B (zh) | 2016-05-04 |
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CN201110413044.3A Active CN102552871B (zh) | 2011-12-13 | 2011-12-13 | 一种鞣酸蛋白酵母咀嚼片及其生产方法 |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102961732A (zh) * | 2012-11-22 | 2013-03-13 | 青岛绿曼生物工程有限公司 | 治疗家兔肠炎的组合物及其制备方法 |
CN106720379A (zh) * | 2016-12-05 | 2017-05-31 | 中国科学院兰州化学物理研究所 | 一种驼血多肽奶片及其制备方法 |
CN108159390A (zh) * | 2016-12-07 | 2018-06-15 | 康芝药业股份有限公司 | 一种含有鞣酸蛋白的散剂 |
CN108523133A (zh) * | 2018-03-28 | 2018-09-14 | 广州富诺营养科技有限公司 | 一种益生菌复合微粒及其制备方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102475721A (zh) * | 2010-11-22 | 2012-05-30 | 大连创达技术交易市场有限公司 | 一种保健用益生菌口服液 |
-
2011
- 2011-12-13 CN CN201110413044.3A patent/CN102552871B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102475721A (zh) * | 2010-11-22 | 2012-05-30 | 大连创达技术交易市场有限公司 | 一种保健用益生菌口服液 |
Non-Patent Citations (1)
Title |
---|
叶国英: "鞣酸蛋白酵母散治疗婴幼儿秋季腹泻疗效观察", 《海峡药学》, vol. 21, no. 8, 31 December 2009 (2009-12-31), pages 131 * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102961732A (zh) * | 2012-11-22 | 2013-03-13 | 青岛绿曼生物工程有限公司 | 治疗家兔肠炎的组合物及其制备方法 |
CN102961732B (zh) * | 2012-11-22 | 2016-04-27 | 青岛绿曼生物工程有限公司 | 治疗家兔肠炎的组合物及其制备方法 |
CN106720379A (zh) * | 2016-12-05 | 2017-05-31 | 中国科学院兰州化学物理研究所 | 一种驼血多肽奶片及其制备方法 |
CN108159390A (zh) * | 2016-12-07 | 2018-06-15 | 康芝药业股份有限公司 | 一种含有鞣酸蛋白的散剂 |
CN108523133A (zh) * | 2018-03-28 | 2018-09-14 | 广州富诺营养科技有限公司 | 一种益生菌复合微粒及其制备方法 |
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CN102552871B (zh) | 2016-05-04 |
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Address after: 570216 Haikou Road, Nanhai District, Hainan, No. 168, No. Patentee after: HAINAN HONZ PHARMACEUTICAL Co.,Ltd. Address before: 570216 Haikou Road, Nanhai District, Hainan, No. 168, No. Patentee before: Honz Pharmaceutical Co.,Ltd. |
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Denomination of invention: Tannic protein yeast chewable tablet and its production method Effective date of registration: 20220708 Granted publication date: 20160504 Pledgee: Industrial Bank Co.,Ltd. Haikou Branch Pledgor: HAINAN HONZ PHARMACEUTICAL Co.,Ltd. Registration number: Y2022980010136 |
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