CN102552641B - Chinese herbal medicine formula for preventing and treating broiler colibacillosis - Google Patents
Chinese herbal medicine formula for preventing and treating broiler colibacillosis Download PDFInfo
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- CN102552641B CN102552641B CN201210054393.5A CN201210054393A CN102552641B CN 102552641 B CN102552641 B CN 102552641B CN 201210054393 A CN201210054393 A CN 201210054393A CN 102552641 B CN102552641 B CN 102552641B
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Abstract
The invention discloses a Chinese herbal medicine formula for preventing and treating broiler colibacillosis, which belongs to the technical field for breeding broilers. The Chinese herbal medicine formula provided by the invention comprises the components as follows: 12-15 g of cptis chinensis, 10-13 g of sanguisorba officinalis, 6-8 g of isatis root, 9-11 g of astragalus mongholicus, 9-11 g of folium isatidis, 9-11 g of aloes, 12-15 g of honeysuckle, 10-12 g of radix scutellariae and 10-12 g of liquorice. The Chinese herbal medicine is weighed according to the formula ratio; the weighed Chinese herbal medicine is decocted and boiled twice through adding water; the decocted liquid and boiled liquid are combined together to be concentrated into aqueous solution; each 1 mL of aqueous solution comprises 1 g of crude drug; and then the aqueous solution is disinfected and filled under a sterile condition. The Chinese herbal medicine formula provided by the invention is capable of improving the immunity and premonition of the broiler, and has no drug tolerance and drug residue. The treating cost for the broiler is reduced; the slaughter weight of the broiler is improved to over 23.8%; and the economic benefit and the social benefit of broiler breeding are improved.
Description
Technical field
The invention belongs to broiler breeding technical field, is a kind of Chinese herbal medicine additive, for preventing and treating broiler colibacillosis specifically.
Background technology
In prior art for the control of broiler colibacillosis, generally to be used alternatingly gentamycin, cephalosporin, three kinds of antibiotic of streptomycin, the consumption that by specification indicates is added to the water, allow chicken at twice (morning, afternoon each once) in 2h, freely drink, within every 10 days, drink 3 days.Its shortcoming is easily to produce drug resistance, causes weak curative effect; And after using, inevitably produce drug residue, affect broiler product quality, jeopardize food safety and human health.
Summary of the invention
The present invention easily produces the problem of drug resistance and drug residue in order to solve the medicine adopting in the therapeutic modality of the broiler colibacillosis using in prior art, propose a kind of Chinese herbal medicine formula and be used for preventing and treating broiler colibacillosis.
The formula of Chinese herbal medicine provided by the invention is: 10～12 grams, 12～15 grams of Rhizoma Coptidis, 10～13 grams of Radix Sanguisorbaes, 6～8 grams of Radix Isatidis, 9～11 grams of the Radixs Astragali, 9～11 grams of Folium Isatidiss, 9～11 grams of Aloes, 12～15 grams of Flos Loniceraes, 10～12 grams of Radix Scutellariaes and Radix Glycyrrhizae.
Preferably, Chinese herbal medicine formula is: 12 grams of Rhizoma Coptidis, 10 grams of Radix Sanguisorbaes, 6 grams of Radix Isatidis, 9 grams of the Radixs Astragali, 9 grams of Folium Isatidiss, 9 grams of Aloes, 12 grams of Flos Loniceraes, 10 grams of Radix Scutellariaes, 10 grams, Radix Glycyrrhizae.
In another preferred embodiment, Chinese herbal medicine formula is: 15 grams of Rhizoma Coptidis, 13 grams of Radix Sanguisorbaes, 8 grams of Radix Isatidis, 11 grams of the Radixs Astragali, 11 grams of Folium Isatidiss, 11 grams of Aloes, 15 grams of Flos Loniceraes, 12 grams of Radix Scutellariaes, 12 grams, Radix Glycyrrhizae.
Preparation method: Chinese herbal medicine is taken by formula proportion, decoct with water twice, collecting decoction, is condensed into every 1mL containing the water preparation of 1g crude drug, aseptic sterilization fill.
The invention has the advantages that:
(1) improve immunity and the premunition of broiler;
(2) have no drug resistance, drug residue free;
(3) reduce the medical expense of broiler;
(4) body weight of delivering for sale of broiler improves more than 23.8%, improves economic benefit and the social benefit of broiler breeding.
The specific embodiment
The invention provides a kind of Chinese herbal medicine formula of preventing and treating broiler colibacillosis, concrete Chinese herbal medicine comprises: 12～15 grams of Rhizoma Coptidis, 10～13 grams of Radix Sanguisorbaes, 6～8 grams of Radix Isatidis, 9～11 grams of the Radixs Astragali, 9～11 grams of Folium Isatidiss, 9～11 grams of Aloes, 12～15 grams of Flos Loniceraes, 10～12 grams of Radix Scutellariaes, 10～12 grams, Radix Glycyrrhizae.
Preparation method: Chinese herbal medicine is taken by formula proportion, put into marmite, add water 500ml and soak 1 hour, decoct 30-40 minute, pour out after first pass medicinal liquid, then add water 300ml continuation decoction 20-30 minute, pour out medicinal liquid.Merge medicinal liquid twice, be filled into and be with in graduated beaker, on electric furnace, continue heating, until be condensed into the water preparation that contains 1g crude drug in every 1mL decocting liquid, by medicinal liquid and Packaging Bottle autoclaving, in superclean bench, carry out fill, sealing.
embodiment 1:
Choosing Chinese herbal medicine formula is: 12 grams of Rhizoma Coptidis, 10 grams of Radix Sanguisorbaes, 6 grams of Radix Isatidis, 9 grams of the Radixs Astragali, 9 grams of Folium Isatidiss, 9 grams of Aloes, 12 grams of Flos Loniceraes, 10 grams of Radix Scutellariaes, 10 grams, Radix Glycyrrhizae.
Chinese herbal medicine is taken by formula proportion, put into marmite, add water 500ml and soak 1 hour, decoct 30-40 minute, pour out after first pass medicinal liquid, then add water 300ml continuation decoction 20-30 minute, pour out medicinal liquid.Merge medicinal liquid twice, be filled into and be with in graduated beaker, on electric furnace, continue heating, until be condensed into the water preparation that contains 1g crude drug in every 1mL decocting liquid (being medicinal liquid), by medicinal liquid and Packaging Bottle autoclaving, in superclean bench, carry out fill, sealing.The Chinese herbal and crude drugs preparations preparing is added to the water (water yield is determined by the number of elements of chicken and daily drink amount) in the ratio of 1ml/ pcs/day, at twice (upper and lower noon each with once) allow chicken freely drink, within every 9 days, drink 3 days (drinking inactive 2 days 1 day).
embodiment 2:
Choosing Chinese herbal medicine formula is: 15 grams of Rhizoma Coptidis, 13 grams of Radix Sanguisorbaes, 8 grams of Radix Isatidis, 11 grams of the Radixs Astragali, 11 grams of Folium Isatidiss, 11 grams of Aloes, 15 grams of Flos Loniceraes, 12 grams of Radix Scutellariaes, 12 grams, Radix Glycyrrhizae.
Chinese herbal medicine is taken by formula proportion, put into marmite, add water 500ml and soak 1 hour, decoct 30-40 minute, pour out after first pass medicinal liquid, add again water 300ml and continue to decoct 20-30 minute, merge twice decocting liquid (also claiming medicinal liquid), be filled into and be with in graduated beaker, on electric furnace, continue heating, until be condensed into the water preparation that contains 1g crude drug in every 1mL decocting liquid, by medicinal liquid and Packaging Bottle autoclaving, in superclean bench, carry out fill, sealing.The Chinese herbal and crude drugs preparations preparing is added to the water (water yield is determined by the number of elements of chicken and daily drink amount) in the ratio of 1ml/ pcs/day, at twice (upper and lower noon each with once) allow chicken freely drink, within every 9 days, drink 3 days (drinking inactive 2 days 1 day).Result shows, uses the broiler of Chinese herbal medicine formula provided by the invention, and immunity and premunition obviously improve, and the body weight of delivering for sale of broiler improves more than 23.8%.
Escherichia coli adopt plate dilution method to the in vitro tests of the sensitivity of Chinese herbal medicine formula provided by the invention, carry out two groups of tests, and first group is specially:
Get 1ml original liquid and add the 1st test tube; In the 2nd test tube, add respectively 0.5ml original liquid and 0.5ml normal saline to be diluted to the 4th test tube with coubling dilution; The 5th test tube is without medicine control tube.First respectively medicinal liquid is poured in aseptic plate, 60 ℃ of aseptic ordinary nutrient agars of rear impouring or maconkey agar, and rapid mix homogeneously, make flat board.With aseptic spreading rod, dip test and evenly coat planar surface with antibacterial, put in 37 ℃ of incubators and cultivate after 24h, observe and record result.
Second group is specially: at the 1st test tube, add 8ml original liquid, the 2nd test tube adds 4ml original liquid, the 3rd test tube adds 2ml original liquid, the 4th test tube adds 1ml original liquid, the 5th test tube is without medicine control tube, in 5 test tubes of the 2nd test tube to the, adds respectively 4ml, 6ml, 7ml and 8ml normal saline; Adopt the mode identical with first group to make flat board, in the incubator that coating antibacterial is rearmounted 37 ℃, cultivate after 24h, observe and record result.
Escherichia coli adopt paper disk method to the sensitivity tests of Chinese herbal medicine formula provided by the invention, by what filter out, to escherichia coli, have obvious inhibiting compound recipe, single medicinal material preparation to make respectively drug sensitive test paper, measure the size of inhibition zone.Method: the sterilizing filter paper that cut-off footpath is 0.6cm soaks 40min in original liquid, takes out standby.In the dull and stereotyped Zhong， sterile working that prepared, place drug sensitive test paper, 6 of every kind of medicine pastes, then put flat board and in 37 ℃ of incubators, cultivate the size of measuring inhibition zone after 24h, get its meansigma methods.
By having obvious inhibiting Chinese herbal medicine application paper disk method to measure it to colibacillary bacteriostasis to colibacillary growth in flat band method bacteriostatic test, the results are shown in Table 1.
Table 19 kind of Chinese herbal medicine is to colibacillary antibacterial result
Visible, the 9 kinds of Chinese herbal medicine (single, compound recipe) that filter out by plate dilution method all have inhibitory action in various degree to escherichia coli.Therefore, when carrying out paper disk method drug sensitive test with these 9 kinds of Chinese medicines, there is inhibition zone to occur.As can be seen from the results, under high concentration (1.0g crude drug/L), Rhizoma Coptidis, Radix Scutellariae, Radix Glycyrrhizae, Radix Isatidis, Aloe, Radix Sanguisorbae, the Radix Astragali, Folium Isatidis, Flos Lonicerae decoction liquor have obvious bacteriostasis, relevant with the concentration of antibacterial Chinese herbal medicine on the one hand, on the other hand, on flat board, be coated with colibacillary quantity and mode also influential.
At broiler jumpbogroup, carry out effect test, test group survival rate is 97.9%, and matched group survival rate is 98.4%, and difference is not remarkable.Test group is on average delivered body weight 2230g for sale, and matched group is on average delivered body weight 1800g for sale, and test group is significantly higher than matched group.
The Chinese herbal medicine formula screening in the present invention has antibiotic, antivirus action significantly, can improve immunity and the premunition of broiler, the successful of dual function is better than single antibiotic, have no drug resistance and nuisanceless incomparable characteristics and advantages especially, reduce medical expense, improved economic benefit and the social benefit of broiler breeding.
Claims (4)
1. the herbal composite of control broiler colibacillosis, is characterized in that: the component proportion of herbal composite is: 10～12 grams, 12～15 grams of Rhizoma Coptidis, 10～13 grams of Radix Sanguisorbaes, 6～8 grams of Radix Isatidis, 9～11 grams of the Radixs Astragali, 9～11 grams of Folium Isatidiss, 9～11 grams of Aloes, 12～15 grams of Flos Loniceraes, 10～12 grams of Radix Scutellariaes and Radix Glycyrrhizae; The preparation method of described herbal composite is: herbal component is taken by formula proportion, put into marmite, add water 500ml and soak 1 hour, decoct 30-40 minute, pour out after first pass medicinal liquid, then add water 300ml continuation decoction 20-30 minute, pour out medicinal liquid; Merge medicinal liquid twice, be filled into and be with in graduated beaker, on electric furnace, continue heating, until be condensed into the water preparation that contains 1g crude drug in every 1mL decocting liquid.
2. the herbal composite of control broiler colibacillosis according to claim 1, is characterized in that: the component proportion of herbal composite is: 12 grams of Rhizoma Coptidis, 10 grams of Radix Sanguisorbaes, 6 grams of Radix Isatidis, 9 grams of the Radixs Astragali, 9 grams of Folium Isatidiss, 9 grams of Aloes, 12 grams of Flos Loniceraes, 10 grams of Radix Scutellariaes, 10 grams, Radix Glycyrrhizae.
3. the herbal composite of control broiler colibacillosis according to claim 1, is characterized in that: the component proportion of herbal composite is: 15 grams of Rhizoma Coptidis, 13 grams of Radix Sanguisorbaes, 8 grams of Radix Isatidis, 11 grams of the Radixs Astragali, 11 grams of Folium Isatidiss, 11 grams of Aloes, 15 grams of Flos Loniceraes, 12 grams of Radix Scutellariaes, 12 grams, Radix Glycyrrhizae.
4. the preparation method of the herbal composite of control broiler colibacillosis according to claim 1, it is characterized in that: Chinese herbal medicine is taken by component proportion, put into marmite, adding water 500ml soaks 1 hour, decoct 30-40 minute, pour out after first pass medicinal liquid, then add water 300ml continuation decoction 20-30 minute, pour out medicinal liquid; Merge medicinal liquid twice, be filled into and be with in graduated beaker, on electric furnace, continue heating, until be condensed into the water preparation that contains 1g crude drug in every 1mL decocting liquid.
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| CN103156096B (en) * | 2013-04-02 | 2014-06-04 | 陈景河 | Pigeon feed additive |
| CN107296920A (en) * | 2017-06-28 | 2017-10-27 | 普定县陇泉湾养殖有限公司 | A kind of medicine for treating meat rabbit colibacillosis and preparation method thereof |
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| CN101209307A (en) * | 2006-12-25 | 2008-07-02 | 天津市润拓生物技术有限公司 | Chinese medicinal oral liquid with heat-clearing and detoxication, dampness-eliminating and dysentery-stopping efficacy |
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| CN101554414B (en) * | 2008-04-09 | 2011-04-27 | 北京大北农动物保健科技有限责任公司 | Traditional Chinese medicine mixture for treating livestock and poultry virosis and preparation method thereof |
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|---|---|---|---|---|
| CN1781522A (en) * | 2004-11-30 | 2006-06-07 | 王丙尧 | Chinese medicine composition for treating avian flu |
| CN101209307A (en) * | 2006-12-25 | 2008-07-02 | 天津市润拓生物技术有限公司 | Chinese medicinal oral liquid with heat-clearing and detoxication, dampness-eliminating and dysentery-stopping efficacy |
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