CN1025410C - 无创测量血糖浓度的方法和装置 - Google Patents
无创测量血糖浓度的方法和装置 Download PDFInfo
- Publication number
- CN1025410C CN1025410C CN90108775A CN90108775A CN1025410C CN 1025410 C CN1025410 C CN 1025410C CN 90108775 A CN90108775 A CN 90108775A CN 90108775 A CN90108775 A CN 90108775A CN 1025410 C CN1025410 C CN 1025410C
- Authority
- CN
- China
- Prior art keywords
- blood
- laser diode
- light
- millimeters
- measuring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Optics & Photonics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Emergency Medicine (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
无创测量血糖浓度的方法和装置。本发明使来自半导体二极管激光器的波长为1.3-1.9微米的电磁辐射线,通过皮肤传到血管。在那里光与血液中的不均匀成分相互作用,然后由血液漫反射。被反射的光将为血液主要成分的分子的特性振动所调制。该反射光被检测并以数字信号提供给单片微计算机。该单片微计算机根据该数字信号并参照储存在其存储器中的一条标定曲线算出血糖浓度。然后将该浓度值显示在数字显示器上。
Description
本发明涉及测量血糖浓度的方法和装置,具体涉及使用近红外辐射漫反射激光光谱测定法来测量血糖浓度的无创技术。
一般地说,糖尿病患者每天要使用便携式测量装置测量血糖浓度2至8次,该装置包括一个注射器(取血样)和试纸(测试血内葡萄糖量)。这就是众所周知的“酶”测法。
血糖浓度的酶测法因需抽血和费用高而不受欢迎。虽然现已引用基于试纸的、花费较少的方法,但是它们的精度较差并且仍然需要抽血。因此,业已进行研究以致力于解决这些问题。
人们希望提供一种准确而不需抽血的、测量血糖浓度的方法。
为此,本发明的一个目的是提供一种无创测量血糖浓度的技术,亦即为进行这项测量而无需抽血。
本发明的另一目的是提供一种方便而价廉、便携和容易使用的测量血糖浓度的装置。
本发明基于近红外照射漫反射激光光谱学,借助用无害电磁射线辐照血管来测量血糖浓度。本发明利用具有能穿过皮肤到达测量部位(例如血管)的波长的电磁波的辐照。由于皮肤主要是由水组成的,水几乎在整个红外光谱范围内吸收红外射线,因此在称为“水传输窗口”的红外光谱范围中只有某一窄小部分的射线能穿透皮肤。
直到最近,水传输窗口被认为只包含3-5μm之间的波长。然而,根据本发明人的调查研究,能够通过水传输窗口到达血管的波长包括1.3-1.9微米之间的波长。
据此,本发明使用了来自一个半导体二极管激光器的1.3-1.9微米波长射线的电磁波进行照射。当这些波长的电磁波照射皮肤时,光穿过皮肤到达血管,在那里光与血液的不均匀成分(heterogeneons componmt)相互作用。到达血液的光经由血液漫反射。被反射的光将为血液主要组分的分子的特性振动所调制。
在本发明中,上述被漫反射的光由一个汇集单元(integrating unit)来汇集。如上所述被汇集的光子(hγ)由一个检测器转换为电测值并将该值提供给一个处理装置(例如一个单片微计算机)。该单片微计算机利用精确的标定方法来计算血糖浓度。在本发明中近红外线辐照规定如下(根据国际理论与应用化学联合会(IUPAC)的规定)频率约为1013-3.75×1014赫兹,能量约为0.951-35.8(千卡/克分子),0.0412-1.55电子伏特;波长约为0.8-30微米。本发明基于有关描述用近红外辐射漫反射激光光谱测定法测量血糖分子振动运动的物理和化学原理。这种振动运动既包括转动运动也包括平移运动,还包括谐波振动和组合振动。在这些振动之中,谐波振动是主要的。
在本发明中包含的分析方法包括一个数学模型,该模型基于本发明人为了确定血糖浓度而改善的多线性回归分析和多变量分析。
多线性回归分析和多变量分析本身是众所周知的数字方法,无须多加解释。发明人参考过许多有关文献,其中有几种分析方法均可使用,然而发明人只用了一种数字方法,该方法是以多线性回归分析和多变量分析为基础的,特别是将这两种分析方法结合起来进行了改善。
用于本发明的数学算法是基于对上述两分析方法的改善,该改善表现为:
分析函数是:
Ci=f(P,T,I,Tm,Z,……)
其中Ci为血糖浓度;
P为激光二极管(针形二极管,pin diode)的输出功率;
T为透射量(transmission);
I为激光二极管所通的电流;
Tm为激光二极管(激光芯片,laserchip)的温度;
Z为在血糖无创分析中人体组织其他部分引起的可能“强度(intensity)”。
为计算血糖浓度,要用到操作参数P、T、Tm。
参数的变换量(transformation)
X≡P
Y≡I,Tm,T
Z≡其他部分的“强度”
于是得出
Ci=α+β·Xa/Xg·[1+∑γij·(Ya/Yg)j]+∑δij·(Za/Zg)j
这一方程是发明人正在应用的一些其他改善方法中的一个例子。
a)每次测量均提供了由确定的值X、Y和Z构成的一组数据。所有的原始数据Y、Z都作变换,使其正归化为X。例如:
Y′ i=Xmax-(Ymax-Yi)·(Xmax-Xmin/(Ymax-Ymin)
△Y=△X
b)为了校正,测量的数据(测量持续不到40秒,并包含约160个子数据)要作变换,使之正规化为:
1/n·
Qi
其中Qi=(
<math> <FROM>i = 1<TO>n<OF> </PRODUCT> </math> Rj)1/m(π为几何和)
而 Rj为Xj,Y′ j,Z′ j
c)为了校正,取自一个人或许多人的若干次测量数据要作变换,并再次按类似b)中所述的方式借助一些因子(发明人用算术和几何方法求得的)使其正规化。
第一次结果表明,在血糖浓度为40-400mg/dl的分析范围内,分析的相对估计误差小于0.05;另一方面,重复测量的相对精度值小于0.04。这两个值都涉及校正函数的浓度平均值。
上述估计的统计误差,是在与利用其他可靠的化学或生化方法而获得的数值进行比较而计算出来的。
以上可参看文献:V.V.Nalimov著的“The Application of Mathematical Statistics to Chemical Analysis”,Pergamon Press 1963。
本发明提供用以测量血糖浓度的一种方法和装置,它具有患者容易使用和化费最低的优点。本发明没有耗能部件并且是便携式的,能方便地在户外进行测试。本发明要比先有技术方便得多。此外,本发明不存在由长期使用注射器可能造成对身体的伤害等弊病。
本发明的测量装置可在短时间内不被人注意地测量血糖浓度。因而将使先有技术因其不便和昂贵终被废弃。
本发明的上述目的和其它目的通过采用无创技术测量血糖浓度而得以实现。该技术在于:
一个能源,例如电池,它通过电源开关给单片微计算机、数字显示器、激光二极管电源、检测器(如果需要的话),以及光学单元(如果需要的话)供电。该单片微计算机控制所述激光二极管电源,以使它以稳定的电压和温度逐步地给激光二极管供以电流。该激光二极管通过起动/复位开关发出所需波长的辐射。该单片微计算机操作时使由其控制的并驱动所述激光二极管电源的数/模(D/A)转换器将数字
控制信号转换为模拟控制信号。
于是,激光二极管电源使激光二极管发出适合于测量所需波长的光。来自激光二极管的光要经平行校准,或受光学上的控制、分开或组合。利用受光学控制的光照射邻近血管处的皮肤,穿过皮肤由血液吸收,分散和漫反射返回的光由一个汇集单元进行汇集。由该汇集单位收集的光子由检测器转换为模拟电信号。该模拟电信号被传送到一个前置放大器,在那里它被放大。将这个放大了的模拟电信号送到模/数(A/D)转换器将其转换为相应的数字信号,并将这个数字信号输出给单片微计算机。该单片微计算机根据该数字信号参照储存在该单片微计算机的存储器内的标定曲线来推算和计算血糖浓度,并将其显示在一个数字显示器上。
本发明采用无创技术测量血糖浓度的装置包括:单片微计算机,用以控制激光二极管电源,以便逐步地以稳定电压和温度给激光二极管供以电流。单片微计算机通过将一被检测值与储存在该微计算机的存储器内一标定曲线相比较来推算和计算血糖浓度;一个数/模转换器,将来自所述单片微计算机输出的数字控制信号转换为模拟控制信号,以控制给激光二极管供电的激光二极管电源,该激光二极管是进行血糖浓度测量的光源,它可包括多个激光二极管,用以根据激光二极管电源提供的电流发射不同波长的光,或相同波长的光;一个温度控制器,用以控制激光二极管的温度,它连接在激光二极管电源和激光二极管之间;一个光学单元,它平行校正激光二极管发出的光,或从光学上控制、分开或组合激光二极管的光;一个汇集单元,用以在光学单元来的光穿过皮肤照射血液时对由血液分散和漫反射的光进行汇集;一个检测器,用以将汇集单元收集的光子转换为一个电的模拟值,然后该值在前置放大器内被放大;一个模/数转换器,将电的模拟测量值转换为数字值;一个数字显示器,用以显示单片微计算机算
出的血糖浓度。
本发明的这些目的和特点以及其它的目的和特点将通过阅读下面参照附图的实施例就会明了附图中;
图1 示出本发明的血糖浓度测量装置的方框图;
图2 是图1所示装置的详细电路图。
下面,参照附图来描述本发明测量装置的最佳实施例。
参照图1,当电源开关1被接通时,电池(通常是4.5-9伏,尤其适合为6伏充电电池)给单片微计算机2供电,同时,该电源向数字显示器3、激光二极管电源4,以及光学单元6(需要时)供电。
当起动/复位开关8接通时,激光二极管电源4根据单片微计算机2提供的控制信号向激光二极管5供电,其结果是,当电流超过阈值电流时(约20毫安),激光二极管电流逐步增加。于是,激光二极管5就开始发射光线。
激光二极管5发出血糖浓度测量所需波长的光(例如:具有1.3-1.9微米波长的光,尤其是具有1.4-1.8微米波长的光或其它)。这个波长的取得是通过逐步增加这样的电流来实现的,该电流是根据激光二极管的特性以稳定的电压和温度在约为20-200毫安范围内提供的。在本发明中,激光二极管5包含1-30个二极管,每个二极管都能发射不同波长的光或相同波长的光。
来自激光二极管5中收集二极管(collective diodes)发射的光可由这些二极管同时发射,或各二极管依次顺序发射。在同时工作的情况下,长度就要被选定,例如用傅里叶变换来选取。
从激光二极管5的收集二极管输出的光施加到光学单元6并且被校正,或者使该光受光学控制、分开或组合。然后让该光经过一个汇集单元9,再在一个或多个方向上分光。
经过汇集单元9的光连续地照射对象的皮肤,或者连续照射到在
这种情况下事先准备好的一个参考测头组件上,在这里,该参考测头部件并不是必不可少的。
由血液吸收、分散或漫反射的光在由汇集单元9汇集之后由检测器7进行检测。该汇集单元呈球状或类似形状。在这里,汇集单元9长、宽、高的尺寸小于2.56厘米,合适的大小是小于1.28厘米,特别是小于0.64厘米。该汇集单元汇集由血液分散和反射的光。
如上所述检测的电模拟测量值由连接到该检测器7上的一个前置放大器进行放大。然后这个电模拟测量值由模/数转换器11转换为数字测量值。
接着,单片微计算机2通过将这个由模/数转换器11转换为数字测量值的信号与储存在该单片微计算机2的存储器内的一个标定曲线相比较,来计算该被测值。将该计算得出的数值显示在数字显示器3上。
上述测量装置的尺寸可以是:宽×长×高小于170毫米×80毫米×25毫米,合适的是小于150毫米×75毫米×22毫米,特别是小于130毫米×70毫米×20毫米。
光敏二极管适合作为检测器7,并且可以是锗检测器,更具体地说,可以是与一个前置放大器相连接的锗检测器。另外,光学单元6包括形成光的元件,它的尺寸小于0.5-5毫米(尤其小于2毫米),以便平行地聚光和漫射光。
再者,本发明并非局限于具有球状或类似形状的汇集单元9,而它还可以是椭圆形或半椭圆形或其它的形状。
在本发明中,该测头组件可与上述的测量装置分开。在这种情况下,激光二极管5发射的光可通过光纤传送给该组件,该组件与所述测量装置之间的距离是100-1000毫米,其中,包括合适的是500毫米,更具体地说,可以是300毫米。当然,该组件不能与所述测量装置
分开。
本发明不限于单片微计算机2与数/模转换器10和模/数转换器11分离,它也可以是包含在数/模转换器10和模/数转换器11之内的一个单片微计算机2。
此外,在本发明中,它可与辅助电路12一起使用,该辅助电路包括随机存储器RAM121和可擦可编程序只读存储器122,用以辅助单片微计算机2的一个操作。
本发明并不局限于血糖浓度的测量,例如,还可以用于胆甾醇浓度或酒精浓度的测量。
如上所述,根据本发明,提供了一种经济的无创方式测量血糖浓度的方法和装置,只要将该装置的测头组件放在人体的看得见血管的某一部位上便可容易地测出血糖浓度,而无须用诸如常规的注射器那样的器械。
Claims (8)
1、一种测量血糖浓度的方法,包括以下步骤:
通过电源开关让电池给处理装置、数字显示器、激光二极管电源、检测器以及光学单元供电;
控制所述处理装置以使所述激光二极管电源通过起动/复位开关以稳定的电压和温度逐渐地给所述激光二极管提供电流;
控制所述处理装置以使连接在所述处理装置与所述激光二极管电源之间的一个数/模转换器将数字控制信号转换为电控制信号;
借助于所述激光二极管电源,在所述激光二极管内发射有足以满足测量要求的波长的光,其中由所述激光二极管发射机的电磁辐射的波长是在近红外线区域内,尤其是1.3至1.9微米,特别是1.4至1.8微米;
校正由激光二极管发射的光,使之平行于相应的目标,或者光学控制、分开或组合所述激光二极管发出的光;
通过一个汇集单元使所述光学控制的光照射到一条血管上,以测量血糖浓度;
在光穿过皮肤到达血液之后,借助于上述汇集单元对由该血液吸收、散射和慢反射的光进行汇集;
在将上述汇集单元汇集的并由所述检测器检测的光子转换为电的模拟测量值以后,将连接在所述检测器的一个前置放大器所放大的信号传送给一个模/数转换器;
在由所述模/数转换器将所述电模拟测量值转换为数字测量值以后,将该信号传送到所述处理装置;
通过将储存在所述处理装置的存储区内的一条标定曲线与由所述模/数转换器转换的数字测量值相比较,推测和计算血糖浓度;
在所述数字显示器上显示计算出的血糖浓度。
2、根据权利要求1所述的测量血糖浓度的方法,其中所述测量方法是基于利用谐波振动和其它类型振动的组合以及由于振动、旋转和平移运动而引起在近红外辐射漫反射激光光谱学中血糖分子振动运动的物理原理和化学原理。
3、根据权利要求1所述的测量血糖浓度的方法,其中,通过将储存在所述处理装置的存储器内一标定曲线与由所述模/数转换器转换的数字测量值相比较来推测和计算血糖浓度的步骤是使用了诸如多线性回归分析和多变量分析的数学方法。
4、一种测量血糖浓度的装置,它包括:
处理装置,用以控制激光二极管电源提供给激光二极管的电流的流动以使电流以稳定的电压和温度等级逐步地施加,所述处理装置通过将检测器检测和转换的一个电的模拟测量值与储存在所述处理装置的存储器内的标定曲线相比较而推算和计算血糖浓度;
一个数/模转换器,通过将一个数字控制信号转换为模拟控制信号来控制激光二极管电源,其中所述激光二极管电源作为血糖浓度测量的一个光源作为血糖浓度测量的一个光源对所述激光二极管供以电源,所述激光二极管包括多个二极管,它们根据所述激光二极管电源提供的电流发出不同波长的发射光或者相同波长的发射光,其中由所述激光二极管发射的电磁辐射的波长是在近红外线区域内,尤其是1.3至1.9微米,特别是1.4至1.8微米;
一个温度控制器,用以控制所述激光二极管的温度,所述温度控制器连接在所述激光二极管电源与所述激光二极管之间;
一个光学单元,用以校正所述激光二极管所发射的光使之平行于相应的目标,并且光学地控制、分开或组合所述激光二极管所发射的光;
一个汇集单元,通过将由所述光学单元控制的光照射到一位糖尿病患者的作为测量部位的皮肤上,该汇集单元则汇集由血液散射和漫反射的光;
一个检测器,在将上述汇集单元汇集的光子转换为电模拟测量值以后,借助于与其连接的前置放大器放大一个信号;
一个模/数转换器,用以将所述电的模拟测量值转换为数字测量值;以及
一个数字显示器,用以显示所述推算和计算的血糖浓度。
5、根据权利要求4所述的测量血糖浓度的装置,其中由所述激光二极管发射的光同时通过皮肤照射血液,或者顺序地通过皮肤照射血液。
6、根据权利要求4所述的测量血糖浓度的装置,其中所述的汇集单位呈球状、椭圆形或半椭圆形或其它形状;以及
所述测量装置的宽×长×高小于130毫米×70毫米×20毫米,尤其适合于小于150毫米×75毫米×22毫米,更具体地说,适合于小于130毫米×70毫米×20毫米。
7、根据权利要求4所述的测量血糖浓度的装置,其中测头组件可借助于光纤与该测量装置分开,而且该组件与测量装置之间的距离是100-1000毫米,尤其适合于500毫米,更适合于300毫米。
8、根据权利要求4所述的测量血糖浓度的装置,其中使用一个光敏二极管作为所述检测器用以检测由所述汇集单元汇集的光子,并且使用一个锗检测器,更具体地说,使用一个连接到一前置放大器的锗检测器;
所述数/模转换器和模/数转换器是与所述处理装置分离的,或者包括在所述处理装置之内;以及
作为所述电源的是4.5至9伏的电池,尤其适合用6V的充电电池。
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR15584/89 | 1989-10-28 | ||
KR1019890015584A KR930011586B1 (ko) | 1989-10-28 | 1989-10-28 | 난-인베이시브 혈당농도 측정방법 및 그 장치 |
KR1019900011241A KR920002091A (ko) | 1990-07-24 | 1990-07-24 | 난-인베이시브 혈당농도 측정방법 및 그 장치 |
KR11241/90 | 1990-07-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1051297A CN1051297A (zh) | 1991-05-15 |
CN1025410C true CN1025410C (zh) | 1994-07-13 |
Family
ID=26628109
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN90108775A Expired - Fee Related CN1025410C (zh) | 1989-10-28 | 1990-10-27 | 无创测量血糖浓度的方法和装置 |
Country Status (9)
Country | Link |
---|---|
US (1) | US5267152A (zh) |
EP (1) | EP0426358B1 (zh) |
JP (2) | JPH03146032A (zh) |
CN (1) | CN1025410C (zh) |
AT (1) | ATE179874T1 (zh) |
CA (1) | CA2028261C (zh) |
DE (1) | DE69033104T2 (zh) |
HU (1) | HU213438B (zh) |
RU (1) | RU2122208C1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100427025C (zh) * | 2003-04-10 | 2008-10-22 | 宇东科技股份有限公司 | 一种测量血糖浓度的方法 |
Families Citing this family (202)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5237178A (en) * | 1990-06-27 | 1993-08-17 | Rosenthal Robert D | Non-invasive near-infrared quantitative measurement instrument |
US6066847A (en) * | 1989-01-19 | 2000-05-23 | Futrex Inc. | Procedure for verifying the accuracy of non-invasive blood glucose measurement instruments |
US5204532A (en) * | 1989-01-19 | 1993-04-20 | Futrex, Inc. | Method for providing general calibration for near infrared instruments for measurement of blood glucose |
US5362966A (en) * | 1990-06-27 | 1994-11-08 | Rosenthal Robert D | Measurement of finger temperature in near-infrared quantitative measurement instrument |
US5574283A (en) * | 1990-06-27 | 1996-11-12 | Futrex, Inc. | Non-invasive near-infrared quantitative measurement instrument |
US5324979A (en) * | 1990-09-26 | 1994-06-28 | Futrex, Inc. | Method and means for generating synthetic spectra allowing quantitative measurement in near infrared measuring instruments |
US5379774A (en) * | 1990-10-23 | 1995-01-10 | Sankyo Company Limited | Measurement of arterial elasticity and the frequency characteristic of the compliance of an artery |
FR2679337B1 (fr) * | 1991-07-17 | 1994-08-12 | Effets Biologiques Exercice | Procede non invasif de determination in vivo du taux de saturation en oxygene du sang arteriel, et dispositif mettant en óoeuvre le procede. |
JPH07508426A (ja) * | 1991-10-17 | 1995-09-21 | サイエンティフィック ジェネリクス リミテッド | 血液検体測定装置及びその方法 |
IL107396A (en) * | 1992-11-09 | 1997-02-18 | Boehringer Mannheim Gmbh | Method and apparatus for analytical determination of glucose in a biological matrix |
US5447159A (en) * | 1993-02-03 | 1995-09-05 | Massachusetts Institute Of Technology | Optical imaging for specimens having dispersive properties |
DE4337570A1 (de) * | 1993-11-04 | 1995-05-11 | Boehringer Mannheim Gmbh | Verfahren zur Analyse von Glucose in einer biologischen Matrix |
US5492118A (en) * | 1993-12-16 | 1996-02-20 | Board Of Trustees Of The University Of Illinois | Determining material concentrations in tissues |
US5497769A (en) * | 1993-12-16 | 1996-03-12 | I.S.S. (Usa) Inc. | Photosensor with multiple light sources |
US5529755A (en) * | 1994-02-22 | 1996-06-25 | Minolta Co., Ltd. | Apparatus for measuring a glucose concentration |
TW275570B (zh) * | 1994-05-05 | 1996-05-11 | Boehringer Mannheim Gmbh | |
DE9417612U1 (de) * | 1994-11-03 | 1995-01-05 | Kloth, Bernd, 22399 Hamburg | Probenabnahmegerät |
DE9418099U1 (de) * | 1994-11-15 | 1995-01-05 | Labor Laborgeräte + Analysensysteme Vertriebsgesellschaft mbH, 22926 Ahrensburg | Analysengerät |
US5752512A (en) * | 1995-05-10 | 1998-05-19 | Massachusetts Institute Of Technology | Apparatus and method for non-invasive blood analyte measurement |
SG38866A1 (en) * | 1995-07-31 | 1997-04-17 | Instrumentation Metrics Inc | Liquid correlation spectrometry |
US6240306B1 (en) | 1995-08-09 | 2001-05-29 | Rio Grande Medical Technologies, Inc. | Method and apparatus for non-invasive blood analyte measurement with fluid compartment equilibration |
US6025597A (en) * | 1995-10-17 | 2000-02-15 | Optiscan Biomedical Corporation | Non-invasive infrared absorption spectrometer for measuring glucose or other constituents in a human or other body |
US6040578A (en) * | 1996-02-02 | 2000-03-21 | Instrumentation Metrics, Inc. | Method and apparatus for multi-spectral analysis of organic blood analytes in noninvasive infrared spectroscopy |
US5747806A (en) * | 1996-02-02 | 1998-05-05 | Instrumentation Metrics, Inc | Method and apparatus for multi-spectral analysis in noninvasive nir spectroscopy |
US5666956A (en) * | 1996-05-20 | 1997-09-16 | Buchert; Janusz Michal | Instrument and method for non-invasive monitoring of human tissue analyte by measuring the body's infrared radiation |
KR0165522B1 (ko) * | 1996-05-23 | 1999-03-20 | 김광호 | 혈증성분 무혈진단을 위한 최적지점 검색장치및 이를 이용한 무혈진단기 |
US5903006A (en) * | 1996-05-31 | 1999-05-11 | Norihiro Kiuchi | Liquid concentration detecting apparatus |
US5871442A (en) | 1996-09-10 | 1999-02-16 | International Diagnostics Technologies, Inc. | Photonic molecular probe |
US6594510B2 (en) | 1996-09-10 | 2003-07-15 | Xoetronics Llc | Photonic molecular probe |
US5910109A (en) | 1997-02-20 | 1999-06-08 | Emerging Technology Systems, Llc | Non-invasive glucose measuring device and method for measuring blood glucose |
US5961451A (en) * | 1997-04-07 | 1999-10-05 | Motorola, Inc. | Noninvasive apparatus having a retaining member to retain a removable biosensor |
US7890158B2 (en) | 2001-06-05 | 2011-02-15 | Lumidigm, Inc. | Apparatus and method of biometric determination using specialized optical spectroscopy systems |
US6628809B1 (en) | 1999-10-08 | 2003-09-30 | Lumidigm, Inc. | Apparatus and method for identification of individuals by near-infrared spectrum |
WO1998058250A2 (en) * | 1997-06-16 | 1998-12-23 | Elan Corporation, Plc | Methods of calibrating and testing a sensor for in vivo measurement of an analyte and devices for use in such methods |
US6043492A (en) * | 1997-10-27 | 2000-03-28 | Industrial Technology Research Institute | Non-invasive blood glucose meter |
US6587705B1 (en) | 1998-03-13 | 2003-07-01 | Lynn Kim | Biosensor, iontophoretic sampling system, and methods of use thereof |
US7875440B2 (en) | 1998-05-01 | 2011-01-25 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
US6780591B2 (en) | 1998-05-01 | 2004-08-24 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
US6097975A (en) * | 1998-05-13 | 2000-08-01 | Biosensor, Inc. | Apparatus and method for noninvasive glucose measurement |
DE69910003T2 (de) | 1998-05-13 | 2004-04-22 | Cygnus, Inc., Redwood City | Überwachung physiologischer analyte |
EP1077636B1 (en) | 1998-05-13 | 2004-01-21 | Cygnus, Inc. | Signal processing for measurement of physiological analytes |
ATE220936T1 (de) | 1998-05-13 | 2002-08-15 | Cygnus Therapeutic Systems | Sammelvorrichtungen für transdermale probennahmesysteme |
CA2330629C (en) | 1998-05-13 | 2007-04-03 | Cygnus, Inc. | Method and device for predicting physiological values |
US6424851B1 (en) | 1998-10-13 | 2002-07-23 | Medoptix, Inc. | Infrared ATR glucose measurement system (II) |
DE19923658A1 (de) * | 1999-05-22 | 2000-11-23 | Infralytic Gmbh | Vorrichtung zum Messen des Organisationsgrades von Wasser in Säugetierkörpern |
US6818395B1 (en) | 1999-06-28 | 2004-11-16 | California Institute Of Technology | Methods and apparatus for analyzing polynucleotide sequences |
US6816605B2 (en) | 1999-10-08 | 2004-11-09 | Lumidigm, Inc. | Methods and systems for biometric identification of individuals using linear optical spectroscopy |
US6361960B1 (en) | 1999-11-09 | 2002-03-26 | Environmentally Sensitive Solutions, Inc. | Method and test kit for measuring concentration of a cleaning agent in a wash liquor |
DE19983992B4 (de) * | 1999-12-21 | 2009-07-23 | Valery Gennadevich Muzhikov | Verfahren zur Bestimmung von Blutcharakteristiken |
CA2404262C (en) * | 2000-03-29 | 2009-03-24 | University Of Virginia Patent Foundation | Method, system, and computer program product for the evaluation of glycemic control in diabetes from self-monitoring data |
US6549861B1 (en) | 2000-08-10 | 2003-04-15 | Euro-Celtique, S.A. | Automated system and method for spectroscopic analysis |
WO2002016905A2 (en) | 2000-08-21 | 2002-02-28 | Euro-Celtique, S.A. | Near infrared blood glucose monitoring system |
US6522903B1 (en) * | 2000-10-19 | 2003-02-18 | Medoptix, Inc. | Glucose measurement utilizing non-invasive assessment methods |
EP1368497A4 (en) | 2001-03-12 | 2007-08-15 | California Inst Of Techn | METHOD AND DEVICE FOR ANALYZING POLYNUCLEOTIDE SEQUENCES BY ASYNCHRONOUS BASE EXTENSION |
US6983176B2 (en) | 2001-04-11 | 2006-01-03 | Rio Grande Medical Technologies, Inc. | Optically similar reference samples and related methods for multivariate calibration models used in optical spectroscopy |
US7043288B2 (en) | 2002-04-04 | 2006-05-09 | Inlight Solutions, Inc. | Apparatus and method for spectroscopic analysis of tissue to detect diabetes in an individual |
US6862091B2 (en) | 2001-04-11 | 2005-03-01 | Inlight Solutions, Inc. | Illumination device and method for spectroscopic analysis |
US7126682B2 (en) | 2001-04-11 | 2006-10-24 | Rio Grande Medical Technologies, Inc. | Encoded variable filter spectrometer |
US6865408B1 (en) | 2001-04-11 | 2005-03-08 | Inlight Solutions, Inc. | System for non-invasive measurement of glucose in humans |
US6574490B2 (en) | 2001-04-11 | 2003-06-03 | Rio Grande Medical Technologies, Inc. | System for non-invasive measurement of glucose in humans |
EP1271096A1 (en) * | 2001-06-18 | 2003-01-02 | Electronic Systems S.P.A. | Process and device for contactless measurement of the thickness of non-metallic films by using an infrared semiconductor emitter |
US6989891B2 (en) | 2001-11-08 | 2006-01-24 | Optiscan Biomedical Corporation | Device and method for in vitro determination of analyte concentrations within body fluids |
JP4083689B2 (ja) * | 2002-03-22 | 2008-04-30 | アニマス テクノロジーズ エルエルシー | 分析物モニタリングデバイスの性能の改良 |
US6654125B2 (en) | 2002-04-04 | 2003-11-25 | Inlight Solutions, Inc | Method and apparatus for optical spectroscopy incorporating a vertical cavity surface emitting laser (VCSEL) as an interferometer reference |
US7027848B2 (en) | 2002-04-04 | 2006-04-11 | Inlight Solutions, Inc. | Apparatus and method for non-invasive spectroscopic measurement of analytes in tissue using a matched reference analyte |
US8175666B2 (en) * | 2002-04-26 | 2012-05-08 | Grove Instruments, Inc. | Three diode optical bridge system |
US7620212B1 (en) | 2002-08-13 | 2009-11-17 | Lumidigm, Inc. | Electro-optical sensor |
ES2456068T3 (es) | 2002-08-13 | 2014-04-21 | University Of Virginia Patent Foundation | Método, sistema y producto de programa informático para el procesamiento de datos de auto-supervisión de glucemia (SMBG) para mejorar la autogestión diabética |
US7233817B2 (en) * | 2002-11-01 | 2007-06-19 | Brian Yen | Apparatus and method for pattern delivery of radiation and biological characteristic analysis |
CN100406872C (zh) * | 2002-11-04 | 2008-07-30 | 天津市先石光学技术有限公司 | 复合光谱测量方法及其光谱检测仪器 |
CN1308740C (zh) * | 2002-11-22 | 2007-04-04 | 天津市先石光学技术有限公司 | 提高声光可调谐滤波器分光光学***信噪比的方法及装置 |
US7174198B2 (en) * | 2002-12-27 | 2007-02-06 | Igor Trofimov | Non-invasive detection of analytes in a complex matrix |
US20040138539A1 (en) * | 2003-01-07 | 2004-07-15 | Jay Paul R. | Non-invasive blood monitor |
ATE492001T1 (de) | 2003-04-04 | 2011-01-15 | Lumidigm Inc | Multispektralbiometriesensor |
US7539330B2 (en) | 2004-06-01 | 2009-05-26 | Lumidigm, Inc. | Multispectral liveness determination |
US7545963B2 (en) | 2003-04-04 | 2009-06-09 | Lumidigm, Inc. | Texture-biometrics sensor |
US7751594B2 (en) | 2003-04-04 | 2010-07-06 | Lumidigm, Inc. | White-light spectral biometric sensors |
US7394919B2 (en) | 2004-06-01 | 2008-07-01 | Lumidigm, Inc. | Multispectral biometric imaging |
US7668350B2 (en) | 2003-04-04 | 2010-02-23 | Lumidigm, Inc. | Comparative texture analysis of tissue for biometric spoof detection |
US7627151B2 (en) | 2003-04-04 | 2009-12-01 | Lumidigm, Inc. | Systems and methods for improved biometric feature definition |
US7460696B2 (en) | 2004-06-01 | 2008-12-02 | Lumidigm, Inc. | Multispectral imaging biometrics |
US7347365B2 (en) | 2003-04-04 | 2008-03-25 | Lumidigm, Inc. | Combined total-internal-reflectance and tissue imaging systems and methods |
US7633621B2 (en) * | 2003-04-11 | 2009-12-15 | Thornton Robert L | Method for measurement of analyte concentrations and semiconductor laser-pumped, small-cavity fiber lasers for such measurements and other applications |
US7283242B2 (en) * | 2003-04-11 | 2007-10-16 | Thornton Robert L | Optical spectroscopy apparatus and method for measurement of analyte concentrations or other such species in a specimen employing a semiconductor laser-pumped, small-cavity fiber laser |
US6958039B2 (en) | 2003-05-02 | 2005-10-25 | Oculir, Inc. | Method and instruments for non-invasive analyte measurement |
US6968222B2 (en) | 2003-05-02 | 2005-11-22 | Oculir, Inc. | Methods and device for non-invasive analyte measurement |
US6975892B2 (en) * | 2003-10-21 | 2005-12-13 | Oculir, Inc. | Methods for non-invasive analyte measurement from the conjunctiva |
US20040225206A1 (en) * | 2003-05-09 | 2004-11-11 | Kouchnir Mikhail A. | Non-invasive analyte measurement device having increased signal to noise ratios |
US7356365B2 (en) * | 2003-07-09 | 2008-04-08 | Glucolight Corporation | Method and apparatus for tissue oximetry |
JP2007533346A (ja) | 2003-08-15 | 2007-11-22 | アニマス・テクノロジーズ・リミテッド・ライアビリティ・カンパニー | 生理学的分析対象のモニタリングに使用するマイクロプロセッサ、デバイス、および方法 |
US7169560B2 (en) | 2003-11-12 | 2007-01-30 | Helicos Biosciences Corporation | Short cycle methods for sequencing polynucleotides |
US7263213B2 (en) | 2003-12-11 | 2007-08-28 | Lumidigm, Inc. | Methods and systems for estimation of personal characteristics from biometric measurements |
US20050137469A1 (en) * | 2003-12-17 | 2005-06-23 | Berman Herbert L. | Single detector infrared ATR glucose measurement system |
US7510849B2 (en) * | 2004-01-29 | 2009-03-31 | Glucolight Corporation | OCT based method for diagnosis and therapy |
JP3557425B1 (ja) * | 2004-02-17 | 2004-08-25 | 株式会社日立製作所 | 血糖値測定装置 |
JP3557424B1 (ja) * | 2004-02-17 | 2004-08-25 | 株式会社日立製作所 | 血糖値測定装置 |
ATE463584T1 (de) | 2004-02-19 | 2010-04-15 | Helicos Biosciences Corp | Verfahren zur analyse von polynukleotidsequenzen |
JP3590053B1 (ja) * | 2004-02-24 | 2004-11-17 | 株式会社日立製作所 | 血糖値測定装置 |
JP3590054B1 (ja) * | 2004-02-26 | 2004-11-17 | 株式会社日立製作所 | 血糖値測定装置 |
US20050192492A1 (en) * | 2004-02-27 | 2005-09-01 | Ok-Kyung Cho | Blood sugar level measuring apparatus |
CA2558239A1 (en) * | 2004-03-06 | 2005-09-22 | Calisto Medical, Inc. | Methods and devices for non-invasively measuring quantitative information of substances in living organisms |
US7635562B2 (en) | 2004-05-25 | 2009-12-22 | Helicos Biosciences Corporation | Methods and devices for nucleic acid sequence determination |
US7476734B2 (en) | 2005-12-06 | 2009-01-13 | Helicos Biosciences Corporation | Nucleotide analogs |
US7508965B2 (en) | 2004-06-01 | 2009-03-24 | Lumidigm, Inc. | System and method for robust fingerprint acquisition |
US8229185B2 (en) | 2004-06-01 | 2012-07-24 | Lumidigm, Inc. | Hygienic biometric sensors |
US20110163163A1 (en) * | 2004-06-01 | 2011-07-07 | Lumidigm, Inc. | Multispectral barcode imaging |
CN1297229C (zh) * | 2004-07-27 | 2007-01-31 | 天津大学 | 脉搏阻抗谱血糖或其他血液成分的无创检测装置及其检测方法 |
US8036727B2 (en) * | 2004-08-11 | 2011-10-11 | Glt Acquisition Corp. | Methods for noninvasively measuring analyte levels in a subject |
US7254429B2 (en) | 2004-08-11 | 2007-08-07 | Glucolight Corporation | Method and apparatus for monitoring glucose levels in a biological tissue |
US7822452B2 (en) | 2004-08-11 | 2010-10-26 | Glt Acquisition Corp. | Method for data reduction and calibration of an OCT-based blood glucose monitor |
US8787630B2 (en) | 2004-08-11 | 2014-07-22 | Lumidigm, Inc. | Multispectral barcode imaging |
WO2006086019A2 (en) * | 2004-10-21 | 2006-08-17 | Optiscan Biomedical Corporation | Methods of treating diabetes |
US7220549B2 (en) | 2004-12-30 | 2007-05-22 | Helicos Biosciences Corporation | Stabilizing a nucleic acid for nucleic acid sequencing |
US7482120B2 (en) | 2005-01-28 | 2009-01-27 | Helicos Biosciences Corporation | Methods and compositions for improving fidelity in a nucleic acid synthesis reaction |
US7801338B2 (en) | 2005-04-27 | 2010-09-21 | Lumidigm, Inc. | Multispectral biometric sensors |
US7409239B2 (en) * | 2005-05-05 | 2008-08-05 | The Hong Kong Polytechnic University | Method for predicting the blood glucose level of a person |
US9278159B2 (en) * | 2005-07-22 | 2016-03-08 | The Board Of Trustees Of The Leland Stanford Junior University | Light-activated cation channel and uses thereof |
US20090093403A1 (en) | 2007-03-01 | 2009-04-09 | Feng Zhang | Systems, methods and compositions for optical stimulation of target cells |
US10052497B2 (en) * | 2005-07-22 | 2018-08-21 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
US8926959B2 (en) * | 2005-07-22 | 2015-01-06 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
US9274099B2 (en) | 2005-07-22 | 2016-03-01 | The Board Of Trustees Of The Leland Stanford Junior University | Screening test drugs to identify their effects on cell membrane voltage-gated ion channel |
US9238150B2 (en) | 2005-07-22 | 2016-01-19 | The Board Of Trustees Of The Leland Stanford Junior University | Optical tissue interface method and apparatus for stimulating cells |
US7666593B2 (en) | 2005-08-26 | 2010-02-23 | Helicos Biosciences Corporation | Single molecule sequencing of captured nucleic acids |
CN100342825C (zh) * | 2005-11-28 | 2007-10-17 | 何宗彦 | 无创快速血糖检测方法及其检测仪 |
WO2007070642A2 (en) * | 2005-12-15 | 2007-06-21 | Helicos Biosciences Corporation | Methods for increasing accuracy of nucleic acid sequencing |
RU2477078C2 (ru) | 2006-01-05 | 2013-03-10 | Юниверсити Оф Вирджиния Пэйтент Фаундейшн | Способ, система и компьютерный программный продукт для оценки изменчивости содержания глюкозы в крови при диабете по данным самоконтроля |
US7397546B2 (en) | 2006-03-08 | 2008-07-08 | Helicos Biosciences Corporation | Systems and methods for reducing detected intensity non-uniformity in a laser beam |
US8175346B2 (en) | 2006-07-19 | 2012-05-08 | Lumidigm, Inc. | Whole-hand multispectral biometric imaging |
EP2041696B1 (en) | 2006-07-19 | 2020-11-18 | HID Global Corporation | Multibiometric multispectral imager |
US7995808B2 (en) | 2006-07-19 | 2011-08-09 | Lumidigm, Inc. | Contactless multispectral biometric capture |
US8355545B2 (en) | 2007-04-10 | 2013-01-15 | Lumidigm, Inc. | Biometric detection using spatial, temporal, and/or spectral techniques |
US7804984B2 (en) | 2006-07-31 | 2010-09-28 | Lumidigm, Inc. | Spatial-spectral fingerprint spoof detection |
US7801339B2 (en) | 2006-07-31 | 2010-09-21 | Lumidigm, Inc. | Biometrics with spatiospectral spoof detection |
US20100298764A1 (en) * | 2006-09-06 | 2010-11-25 | Ofer Yodfat | Fluid delivery system with optical sensing of analyte concentration levels |
DE202006021245U1 (de) | 2006-10-31 | 2014-03-28 | Valery Gennadievich Muzhikov | Einrichtung zur reflektorischen Korrektion von körperlichen Funktionsstörungen |
DE112006003871T5 (de) | 2006-10-31 | 2009-03-19 | Valery Gennadievich Muzhiko | Verfahren zur reflektorischen Korrektion der körperlichen Funktionsstörungen und Einrichtung zur Durchführung des Verfahrens |
US20080154513A1 (en) | 2006-12-21 | 2008-06-26 | University Of Virginia Patent Foundation | Systems, Methods and Computer Program Codes for Recognition of Patterns of Hyperglycemia and Hypoglycemia, Increased Glucose Variability, and Ineffective Self-Monitoring in Diabetes |
WO2008086470A1 (en) | 2007-01-10 | 2008-07-17 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
WO2008101128A1 (en) | 2007-02-14 | 2008-08-21 | The Board Of Trustees Of The Leland Stanford Junior University | System, method and applications involving identification of biological circuits such as neurological characteristics |
WO2008134135A2 (en) | 2007-03-21 | 2008-11-06 | Lumidigm, Inc. | Biometrics based on locally consistent features |
US10434327B2 (en) | 2007-10-31 | 2019-10-08 | The Board Of Trustees Of The Leland Stanford Junior University | Implantable optical stimulators |
US10035027B2 (en) | 2007-10-31 | 2018-07-31 | The Board Of Trustees Of The Leland Stanford Junior University | Device and method for ultrasonic neuromodulation via stereotactic frame based technique |
DE102008006245A1 (de) * | 2008-01-25 | 2009-07-30 | Nirlus Engineering Ag | Verfahren zur nichtinvasiven, optischen Bestimmung der Temperatur eines Mediums |
WO2009111542A2 (en) | 2008-03-04 | 2009-09-11 | Glucolight Corporation | Methods and systems for analyte level estimation in optical coherence tomography |
US20110004080A1 (en) | 2008-04-11 | 2011-01-06 | Glucovista, Llc | Method for non-invasive analysis of a substance concentration within a body |
JP5801188B2 (ja) | 2008-04-23 | 2015-10-28 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 標的細胞を光刺激するためのシステム、方法、および組成物 |
EP2278914A1 (en) * | 2008-05-19 | 2011-02-02 | Koninklijke Philips Electronics N.V. | Perfusion regulation device |
MX2010012986A (es) | 2008-05-29 | 2011-05-25 | Univ Leland Stanford Junior | Linea de celulas, sistema y metodo para control optico de mensajeros secundarios. |
MY162929A (en) | 2008-06-17 | 2017-07-31 | Univ Leland Stanford Junior | Apparatus and methods for controlling cellular development |
SG191593A1 (en) | 2008-06-17 | 2013-07-31 | Univ Leland Stanford Junior | Methods, systems and devices for optical stimulation of target cells using an optical transmission element |
WO2010006049A1 (en) | 2008-07-08 | 2010-01-14 | The Board Of Trustees Of The Leland Stanford Junior University | Materials and approaches for optical stimulation of the peripheral nervous system |
NZ602416A (en) | 2008-11-14 | 2014-08-29 | Univ Leland Stanford Junior | Optically-based stimulation of target cells and modifications thereto |
EP4043878A1 (en) | 2009-02-25 | 2022-08-17 | The University of Virginia Patent Foundation | Method, system and computer program product for cgm-based prevention of hypoglycemia via hypoglycemia risk assessment and smooth reduction insulin delivery |
US7896498B2 (en) * | 2009-03-30 | 2011-03-01 | Ottawa Hospital Research Institute | Apparatus and method for optical measurements |
WO2010138025A1 (ru) | 2009-05-28 | 2010-12-02 | Muzhikov Valery Gennadievich | Устройство для рефлекторной коррекции функциональных нарушений организма |
US8872908B2 (en) | 2009-08-26 | 2014-10-28 | Lumidigm, Inc | Dual-imager biometric sensor |
CN102018517A (zh) * | 2009-09-17 | 2011-04-20 | 林紫谊 | 非侵入式血糖仪 |
US8570149B2 (en) | 2010-03-16 | 2013-10-29 | Lumidigm, Inc. | Biometric imaging using an optical adaptive interface |
JP5866332B2 (ja) | 2010-03-17 | 2016-02-17 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 感光性イオンを通過させる分子 |
CA2816971A1 (en) | 2010-11-05 | 2012-05-10 | The Board Of Trustees Of The Leland Stanford Junior University | Light-activated chimeric opsins and methods of using the same |
CN106106368A (zh) | 2010-11-05 | 2016-11-16 | 斯坦福大学托管董事会 | 光控cns功能障碍 |
EP2635346B1 (en) | 2010-11-05 | 2017-03-29 | The Board of Trustees of the Leland Stanford Junior University | Optogenetic control of reward-related behaviors |
WO2012061684A1 (en) | 2010-11-05 | 2012-05-10 | The Board Of Trustees Of The Leland Stanford Junior University | Upconversion of light for use in optogenetic methods |
AU2011323228B2 (en) | 2010-11-05 | 2016-11-10 | The Board Of Trustees Of The Leland Stanford Junior University | Control and characterization of memory function |
CA2816990A1 (en) | 2010-11-05 | 2012-05-10 | The Board Of Trustees Of The Leland Stanford Junior University | Stabilized step function opsin proteins and methods of using the same |
US8696722B2 (en) | 2010-11-22 | 2014-04-15 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic magnetic resonance imaging |
WO2013090356A2 (en) | 2011-12-16 | 2013-06-20 | The Board Of Trustees Of The Leland Stanford Junior University | Opsin polypeptides and methods of use thereof |
CA2865296A1 (en) | 2012-02-21 | 2013-08-29 | Karl A. DEISSEROTH | Compositions and methods for treating neurogenic disorders of the pelvic floor |
KR101487737B1 (ko) * | 2012-03-21 | 2015-01-29 | 연세대학교 원주산학협력단 | 체내 직접 조사 가능한 레이저 침 시스템 |
WO2014143276A2 (en) | 2012-12-31 | 2014-09-18 | Omni Medsci, Inc. | Short-wave infrared super-continuum lasers for natural gas leak detection, exploration, and other active remote sensing applications |
US10660526B2 (en) | 2012-12-31 | 2020-05-26 | Omni Medsci, Inc. | Near-infrared time-of-flight imaging using laser diodes with Bragg reflectors |
WO2014105520A1 (en) * | 2012-12-31 | 2014-07-03 | Omni Medsci, Inc. | Near-infrared lasers for non-invasive monitoring of glucose, ketones, hba1c, and other blood constituents |
EP2938262A4 (en) | 2012-12-31 | 2016-08-24 | Omni Medsci Inc | SHORT-WAVE INFRARED SUPER CONTINUOUS LASER FOR THE EARLY RECOGNITION OF CARIES |
US9500635B2 (en) | 2012-12-31 | 2016-11-22 | Omni Medsci, Inc. | Short-wave infrared super-continuum lasers for early detection of dental caries |
EP2968997B1 (en) | 2013-03-15 | 2019-06-26 | The Board of Trustees of the Leland Stanford Junior University | Optogenetic control of behavioral state |
US9636380B2 (en) | 2013-03-15 | 2017-05-02 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic control of inputs to the ventral tegmental area |
CN105431046B (zh) | 2013-04-29 | 2020-04-17 | 小利兰·斯坦福大学托管委员会 | 用于靶细胞中的动作电位的光遗传学调节的装置、***和方法 |
CN105188533B (zh) | 2013-04-30 | 2018-09-14 | 雅培糖尿病护理公司 | 用于节能电气装置激活的***、装置以及方法 |
WO2015023782A1 (en) | 2013-08-14 | 2015-02-19 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for controlling pain |
US10441201B2 (en) * | 2013-08-27 | 2019-10-15 | The Trustees Of Princeton Univerisity | Noninvasive mid-infrared in vivo glucose sensor |
EP3175783B1 (de) * | 2014-01-07 | 2022-01-19 | Opsolution GmbH | Vorrichtung und verfahren zur bestimmung einer konzentration in einer probe |
US20160256088A1 (en) * | 2014-02-28 | 2016-09-08 | Tech4Life Enterprises Canada, Inc. | Device and mechanism for facilitating non-invasive, non-piercing monitoring of blood hemoglobin |
CN104188664B (zh) * | 2014-09-01 | 2016-03-30 | 苏州光环科技有限公司 | 血糖检测标定方法及*** |
EP4292529A3 (en) * | 2014-09-22 | 2024-03-20 | DexCom, Inc. | Method for mode switching |
KR102390874B1 (ko) | 2014-10-29 | 2022-04-26 | 삼성전자주식회사 | 혈당 측정기 및 그에 따른 혈당 측정 방법 |
CN104382605A (zh) * | 2014-12-19 | 2015-03-04 | 新乡医学院 | 一种用于大鼠血糖无创快速测定的方法 |
BR112017013630B1 (pt) * | 2014-12-22 | 2022-10-04 | Artem Sergeevich Adzhemov | Método para determinar de modo não invasivo a concentração de glicose no sangue |
CN104950104B (zh) * | 2015-06-12 | 2017-03-01 | 广州睿博医疗科技有限公司 | 四合一生理参数测量仪 |
WO2016209654A1 (en) | 2015-06-22 | 2016-12-29 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and devices for imaging and/or optogenetic control of light-responsive neurons |
CN105342574A (zh) * | 2015-12-11 | 2016-02-24 | 无限极(中国)有限公司 | 一种自动寻肌筋膜扳机点光学仪 |
CN106859666B (zh) * | 2017-02-15 | 2018-12-04 | 舒糖讯息科技(深圳)有限公司 | 一种血糖检测装置及其检测方法 |
US11294165B2 (en) | 2017-03-30 | 2022-04-05 | The Board Of Trustees Of The Leland Stanford Junior University | Modular, electro-optical device for increasing the imaging field of view using time-sequential capture |
CN107174258A (zh) * | 2017-06-02 | 2017-09-19 | 北京信息科技大学 | 血糖浓度预测方法 |
CN107505268A (zh) * | 2017-08-04 | 2017-12-22 | 中国科学院半导体研究所 | 血糖检测方法及*** |
AU2019223992B2 (en) | 2018-02-20 | 2022-03-10 | University Of Iowa Research Foundation | Therapeutic systems using magnetic and electric fields |
US11850440B2 (en) | 2019-08-22 | 2023-12-26 | University Of Iowa Research Foundation | Therapeutic systems using magnetic fields |
US11089981B2 (en) | 2018-07-23 | 2021-08-17 | Samsung Electronics Co., Ltd. | Methods and systems for performing universal calibration to non-invasively determine blood glucose concentration |
CN109846462B (zh) * | 2019-04-03 | 2021-07-16 | 小甑科技(深圳)有限公司 | 一种测量血糖的方法及*** |
RU2718258C1 (ru) * | 2019-07-02 | 2020-03-31 | Федеральное государственное автономное образовательное учреждение высшего образования "Санкт-Петербургский государственный электротехнический университет "ЛЭТИ" им. В.И. Ульянова (Ленина)" (СПбГЭТУ "ЛЭТИ") | Способ неинвазивного определения концентрации глюкозы в крови |
RU2746036C1 (ru) | 2020-08-11 | 2021-04-06 | Валерий Геннадьевич Мужиков | Способ количественной оценки активности акупунктурных каналов, система и модуль для его осуществления |
CN112370607B (zh) * | 2020-12-13 | 2022-08-05 | 李兴阳 | 一种胰岛素泵治疗仪 |
DE102021004609A1 (de) | 2021-09-11 | 2023-03-16 | Eques Consulting GmbH | Vorrichtung und damit durchführbares Verfahren zur non-invasiven Konzentrationsbestimmung von Komponenten im menschlichen Blutkreislauf und Verwendung des Verfahrens. |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU146906A1 (ru) * | 1961-07-14 | 1961-11-30 | В.А. Люхин | Прибор дл фотоплетизмографии |
DE2606991A1 (de) * | 1976-02-20 | 1977-08-25 | Nils Dr Med Kaiser | Geraet zur bestimmung des gehaltes von stoffwechselprodukten im blut |
JPS57124239A (en) * | 1981-01-26 | 1982-08-03 | Aloka Co Ltd | Biochemical component analysis apparatus by laser beam |
ATE26485T1 (de) * | 1981-09-15 | 1987-04-15 | Mueller Arno | Verfahren und vorrichtung zur quantitativen bestimmung geloester substanzen in ein- und mehrkomponentensystemen durch laserlichtstreuung. |
DE3328862A1 (de) * | 1982-09-16 | 1985-02-28 | Siemens AG, 1000 Berlin und 8000 München | Verfahren und vorrichtung zur gewebefotometrie, insbesondere zur quantitativen ermittlung der blut-sauerstoff-saettigung aus fotometrischen messwerten |
US4679562A (en) * | 1983-02-16 | 1987-07-14 | Cardiac Pacemakers, Inc. | Glucose sensor |
JPH0737946B2 (ja) * | 1983-08-05 | 1995-04-26 | 株式会社京都第一科学 | 体液成分を測定するとともにその検査データを保存管理する装置 |
JPS6075032A (ja) * | 1983-09-30 | 1985-04-27 | アロカ株式会社 | レ−ザ光による生化学成分分析装置 |
US4570638A (en) * | 1983-10-14 | 1986-02-18 | Somanetics Corporation | Method and apparatus for spectral transmissibility examination and analysis |
DE3477991D1 (en) * | 1984-05-04 | 1989-06-08 | Kurashiki Boseki Kk | Spectrophotometric apparatus for the non-invasive determination of glucose in body tissues |
US4655225A (en) * | 1985-04-18 | 1987-04-07 | Kurabo Industries Ltd. | Spectrophotometric method and apparatus for the non-invasive |
US4685463A (en) * | 1986-04-03 | 1987-08-11 | Williams R Bruce | Device for continuous in vivo measurement of blood glucose concentrations |
US4759369A (en) * | 1986-07-07 | 1988-07-26 | Novametrix Medical Systems, Inc. | Pulse oximeter |
US4913150A (en) * | 1986-08-18 | 1990-04-03 | Physio-Control Corporation | Method and apparatus for the automatic calibration of signals employed in oximetry |
US4714080A (en) * | 1986-10-06 | 1987-12-22 | Nippon Colin Co., Ltd. | Method and apparatus for noninvasive monitoring of arterial blood oxygen saturation |
GB8700061D0 (en) * | 1987-01-05 | 1987-02-11 | Whatman Reeve Angel Plc | Light absorption analyser |
JPH0827235B2 (ja) * | 1987-11-17 | 1996-03-21 | 倉敷紡績株式会社 | 糖類濃度の分光学的測定法 |
US4800885A (en) * | 1987-12-02 | 1989-01-31 | The Boc Group, Inc. | Blood constituent monitoring apparatus and methods with frequency division multiplexing |
US4882492A (en) * | 1988-01-19 | 1989-11-21 | Biotronics Associates, Inc. | Non-invasive near infrared measurement of blood analyte concentrations |
US5028787A (en) * | 1989-01-19 | 1991-07-02 | Futrex, Inc. | Non-invasive measurement of blood glucose |
US5077476A (en) * | 1990-06-27 | 1991-12-31 | Futrex, Inc. | Instrument for non-invasive measurement of blood glucose |
US5187368A (en) * | 1989-09-29 | 1993-02-16 | Glaxo Inc. | Detection method for liquids using near infrared spectra |
US4977591A (en) * | 1989-11-17 | 1990-12-11 | Nynex Corporation | Dual mode LMS nonlinear data echo canceller |
US5070874A (en) * | 1990-01-30 | 1991-12-10 | Biocontrol Technology, Inc. | Non-invasive determination of glucose concentration in body of patients |
US5054487A (en) * | 1990-02-02 | 1991-10-08 | Boston Advanced Technologies, Inc. | Laser systems for material analysis based on reflectance ratio detection |
-
1990
- 1990-10-22 CA CA002028261A patent/CA2028261C/en not_active Expired - Fee Related
- 1990-10-23 EP EP19900311596 patent/EP0426358B1/en not_active Expired - Lifetime
- 1990-10-23 AT AT90311596T patent/ATE179874T1/de not_active IP Right Cessation
- 1990-10-23 DE DE1990633104 patent/DE69033104T2/de not_active Expired - Fee Related
- 1990-10-24 JP JP2286941A patent/JPH03146032A/ja active Granted
- 1990-10-26 US US07/604,800 patent/US5267152A/en not_active Expired - Lifetime
- 1990-10-26 HU HU906914A patent/HU213438B/hu not_active IP Right Cessation
- 1990-10-26 RU SU4831608A patent/RU2122208C1/ru not_active IP Right Cessation
- 1990-10-27 CN CN90108775A patent/CN1025410C/zh not_active Expired - Fee Related
-
1997
- 1997-08-18 JP JP1997007317U patent/JP2588468Y2/ja not_active Expired - Lifetime
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100427025C (zh) * | 2003-04-10 | 2008-10-22 | 宇东科技股份有限公司 | 一种测量血糖浓度的方法 |
CN101368922B (zh) * | 2003-04-10 | 2010-12-15 | 宇系科技有限公司 | 判断血糖浓度的方法 |
Also Published As
Publication number | Publication date |
---|---|
DE69033104T2 (de) | 1999-10-28 |
ATE179874T1 (de) | 1999-05-15 |
EP0426358B1 (en) | 1999-05-12 |
JP2588468Y2 (ja) | 1999-01-13 |
JPH03146032A (ja) | 1991-06-21 |
CA2028261A1 (en) | 1991-04-29 |
US5267152A (en) | 1993-11-30 |
JPH10181U (ja) | 1998-08-25 |
HUT58145A (en) | 1992-01-28 |
HU213438B (en) | 1997-06-30 |
CA2028261C (en) | 1995-01-17 |
HU906914D0 (en) | 1991-05-28 |
EP0426358A1 (en) | 1991-05-08 |
DE69033104D1 (de) | 1999-06-17 |
JPH0581253B2 (zh) | 1993-11-12 |
CN1051297A (zh) | 1991-05-15 |
RU2122208C1 (ru) | 1998-11-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1025410C (zh) | 无创测量血糖浓度的方法和装置 | |
US6026314A (en) | Method and device for noninvasive measurements of concentrations of blood components | |
US8886268B2 (en) | Living body information measuring apparatus | |
AU749033B2 (en) | Apparatus and method for noninvasive glucose measurement | |
CN102438511B (zh) | 用于无创血糖检测的光谱分析设备和相关使用方法 | |
US8594758B2 (en) | Transmission fluorometer | |
CN1198085A (zh) | 用改进的光学界面进行无创伤血液成分测定的方法 | |
CN101052349A (zh) | 血糖值的非侵入测量装置 | |
CN1771885A (zh) | 利用光的透-反射测量血液成分的装置和方法 | |
CN1830386A (zh) | 低灌注下测量血氧的方法 | |
WO2009061367A2 (en) | Optical sensor for determining the concentration of an analyte | |
CN108181290B (zh) | 一种荧光定量分析仪 | |
US20080023634A1 (en) | Non-invasive detection of analytes in a comples matrix | |
WO2014081586A1 (en) | Non-invasive reagentless glucose determination | |
CN101263388A (zh) | 非侵入性检测人类受检体中葡萄糖的方法和设备 | |
CN1550213A (zh) | 测量待测物中成分浓度的方法和设备 | |
JPH09308623A (ja) | 無侵襲生化学計測装置 | |
US20130267799A1 (en) | Noninvasive measurement of analyte concentration using a fiberless transflectance probe | |
KR20090025958A (ko) | 체액 성분 측정용 비침습 프로브, 이를 포함하는 비침습적체액 성분 측정 시스템, 및 비침습적 체액 성분 측정 방법 | |
KR19990029222A (ko) | 혈중성분 농도의 무혈측정 방법 및 장치 | |
KR930011586B1 (ko) | 난-인베이시브 혈당농도 측정방법 및 그 장치 | |
KR920002091A (ko) | 난-인베이시브 혈당농도 측정방법 및 그 장치 | |
KR920002092A (ko) | 난-인베이시브 혈당농도 측정방법 및 그 장치 | |
CN219439128U (zh) | 一种眼表晚期糖基化终末产物检测装置 | |
CN108670269A (zh) | 一种基于光散射能量的人体无创血糖测量装置 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C15 | Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993) | ||
OR01 | Other related matters | ||
C19 | Lapse of patent right due to non-payment of the annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |