CN102526484B - Medicinal composition for decreasing blood sugar - Google Patents
Medicinal composition for decreasing blood sugar Download PDFInfo
- Publication number
- CN102526484B CN102526484B CN 201210034678 CN201210034678A CN102526484B CN 102526484 B CN102526484 B CN 102526484B CN 201210034678 CN201210034678 CN 201210034678 CN 201210034678 A CN201210034678 A CN 201210034678A CN 102526484 B CN102526484 B CN 102526484B
- Authority
- CN
- China
- Prior art keywords
- parts
- blood sugar
- medicinal composition
- diabetes
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000008280 blood Substances 0.000 title abstract description 20
- 210000004369 blood Anatomy 0.000 title abstract description 20
- 239000000203 mixture Substances 0.000 title abstract description 7
- 230000003247 decreasing effect Effects 0.000 title abstract description 5
- 239000003814 drug Substances 0.000 claims description 27
- 239000007788 liquid Substances 0.000 claims description 27
- 230000002218 hypoglycaemic effect Effects 0.000 claims description 12
- 239000008194 pharmaceutical composition Substances 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 3
- 241000219780 Pueraria Species 0.000 claims description 2
- 241000545442 Radix Species 0.000 claims description 2
- 241001530126 Scrophularia Species 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 7
- 244000241872 Lycium chinense Species 0.000 abstract description 3
- 235000015468 Lycium chinense Nutrition 0.000 abstract description 3
- 240000000249 Morus alba Species 0.000 abstract description 2
- 244000046146 Pueraria lobata Species 0.000 abstract description 2
- 235000012054 meals Nutrition 0.000 abstract description 2
- 241001061264 Astragalus Species 0.000 abstract 1
- 241000132012 Atractylodes Species 0.000 abstract 1
- 235000008708 Morus alba Nutrition 0.000 abstract 1
- 241000972672 Phellodendron Species 0.000 abstract 1
- 241000756042 Polygonatum Species 0.000 abstract 1
- 235000008737 Polygonatum biflorum Nutrition 0.000 abstract 1
- 235000010575 Pueraria lobata Nutrition 0.000 abstract 1
- 235000002226 Ranunculus ficaria Nutrition 0.000 abstract 1
- 244000081426 Ranunculus ficaria Species 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 235000006533 astragalus Nutrition 0.000 abstract 1
- 229940126678 chinese medicines Drugs 0.000 abstract 1
- 210000004233 talus Anatomy 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 17
- 239000012567 medical material Substances 0.000 description 16
- 206010012601 diabetes mellitus Diseases 0.000 description 13
- 229940079593 drug Drugs 0.000 description 13
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 9
- 241000700159 Rattus Species 0.000 description 9
- 239000008103 glucose Substances 0.000 description 9
- 206010037660 Pyrexia Diseases 0.000 description 8
- 238000004321 preservation Methods 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 230000007812 deficiency Effects 0.000 description 7
- 239000009636 Huang Qi Substances 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 5
- 210000002784 stomach Anatomy 0.000 description 5
- 206010011224 Cough Diseases 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 208000031971 Yin Deficiency Diseases 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 239000000706 filtrate Substances 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 239000013641 positive control Substances 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 230000035922 thirst Effects 0.000 description 4
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 4
- 206010012735 Diarrhoea Diseases 0.000 description 3
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 244000052769 pathogen Species 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- 210000000952 spleen Anatomy 0.000 description 3
- 206010007247 Carbuncle Diseases 0.000 description 2
- 206010021118 Hypotonia Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 206010040943 Skin Ulcer Diseases 0.000 description 2
- 208000009205 Tinnitus Diseases 0.000 description 2
- 206010047601 Vitamin B1 deficiency Diseases 0.000 description 2
- 208000002894 beriberi Diseases 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 208000013116 chronic cough Diseases 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000004438 eyesight Effects 0.000 description 2
- 208000017561 flaccidity Diseases 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 201000001881 impotence Diseases 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 208000030159 metabolic disease Diseases 0.000 description 2
- 206010029410 night sweats Diseases 0.000 description 2
- 230000036565 night sweats Effects 0.000 description 2
- 231100000915 pathological change Toxicity 0.000 description 2
- 230000036285 pathological change Effects 0.000 description 2
- 230000000291 postprandial effect Effects 0.000 description 2
- 238000010791 quenching Methods 0.000 description 2
- 206010037844 rash Diseases 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 231100000019 skin ulcer Toxicity 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 2
- 231100000886 tinnitus Toxicity 0.000 description 2
- XPFJYKARVSSRHE-UHFFFAOYSA-K trisodium;2-hydroxypropane-1,2,3-tricarboxylate;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound [Na+].[Na+].[Na+].OC(=O)CC(O)(C(O)=O)CC(O)=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O XPFJYKARVSSRHE-UHFFFAOYSA-K 0.000 description 2
- 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 description 2
- 206010001580 Albuminuria Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 244000089795 Clausena lansium Species 0.000 description 1
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 208000002249 Diabetes Complications Diseases 0.000 description 1
- 206010012655 Diabetic complications Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000201295 Euphrasia Species 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 208000004930 Fatty Liver Diseases 0.000 description 1
- 208000015220 Febrile disease Diseases 0.000 description 1
- 206010018367 Glomerulonephritis chronic Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010019708 Hepatic steatosis Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 244000241838 Lycium barbarum Species 0.000 description 1
- 235000015459 Lycium barbarum Nutrition 0.000 description 1
- 201000005505 Measles Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- IBAQFPQHRJAVAV-ULAWRXDQSA-N Miglitol Chemical compound OCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO IBAQFPQHRJAVAV-ULAWRXDQSA-N 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010028836 Neck pain Diseases 0.000 description 1
- 208000001140 Night Blindness Diseases 0.000 description 1
- 241000037826 Polygonatum kingianum Species 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 241001121987 Scrophularia ningpoensis Species 0.000 description 1
- 241000207844 Scrophulariaceae Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000208292 Solanaceae Species 0.000 description 1
- ZSJLQEPLLKMAKR-UHFFFAOYSA-N Streptozotocin Natural products O=NN(C)C(=O)NC1C(O)OC(CO)C(O)C1O ZSJLQEPLLKMAKR-UHFFFAOYSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 241000282894 Sus scrofa domesticus Species 0.000 description 1
- 206010043458 Thirst Diseases 0.000 description 1
- 206010043866 Tinea capitis Diseases 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 208000005946 Xerostomia Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 229940127003 anti-diabetic drug Drugs 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 239000003472 antidiabetic agent Substances 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 235000019994 cava Nutrition 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 208000019902 chronic diarrheal disease Diseases 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 206010013023 diphtheria Diseases 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 208000010706 fatty liver disease Diseases 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 210000000629 knee joint Anatomy 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 201000007227 lymph node tuberculosis Diseases 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 229960001110 miglitol Drugs 0.000 description 1
- 238000003032 molecular docking Methods 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 229940127017 oral antidiabetic Drugs 0.000 description 1
- 239000003538 oral antidiabetic agent Substances 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 210000003516 pericardium Anatomy 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000001047 pyretic effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 231100000240 steatosis hepatitis Toxicity 0.000 description 1
- 229960001052 streptozocin Drugs 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 208000009189 tinea favosa Diseases 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a medicinal composition for decreasing blood sugar, and relates to the technical field of Chinese medicines. The medicinal composition is prepared from the following active ingredients in part by weight: 14 to 18 parts of mulberry leaf, 8 to 12 parts of kudzuvine root, 8 to 12 parts of figwort root, 8 to 12 parts of manyflower solomonseal rhizome, 8 to 12 parts of Chinese wolfberry root-bark, 10 to 15 parts of phellodendron, 6 to 10 parts of Chinese wolfberry, 8 to 12 parts of astragalus and 6 to 10 parts of swordlike atractylodes rhizome. The medicinal composition has a very good curative effect of decreasing blood sugar levels before and after meals after being taken for a long time, and achieves a good effect of decreasing the blood sugar.
Description
Technical field
The invention belongs to the Chinese medicine technical field, be specifically related to a kind of hypoglycemic pharmaceutical composition.
Background technology
Diabetes are a kind of incretion metabolism diseases, are owing to the relative or absolute not enough carbohydate metabolism disorder that causes of insulin in the body, cause the water of sugar, protein, fat and secondary, the disease of metabolic disturbance of electrolyte.Diabetes are divided two types clinically: insulin dependent diabetes mellitus (IDDM) (being type i diabetes), non-insulin-dependent diabetes mellitus (being type ii diabetes).Wherein, the type ii diabetes rate is very high, accounts for about 90% of onset diabetes number.The harm of diabetes is mainly from complication, and its incidence rate is very high, has caused high fatality rate and high disability rate.Studies show that had 30%～40% patient to I haven't seen you for ages a kind of complication to take place in 10 years behind the onset diabetes.Common diabetic complication has nephropathy that diabetes cause, eyes pathological changes, nervous system lesion, cardiovascular pathological changes, fatty liver etc.
World Health Organization (WHO) announces recently, nineteen ninety-five, whole world diabetics was only about 3,000 ten thousand people, and to 1997 oneself increase to 1.35 hundred million, predict according to the authoritative sources, to reach 2.4 hundred million by 2010, by 2025, will have 3.3 hundred million people to be diagnosed as diabetes, and mortality rate is only second to malignant tumor and cardiovascular diseases, is the third-largest disease that jeopardizes human life's health.Along with the raising of living standards of the people, the incidence rate of China's diabetics and mortality rate are also increasing severely year by year.The finding that distributes from China each department, the eighties China's diabetics sickness rate less than 1%, risen to 2.65% by 1997, and more increased rapidly with annual 0.1% speed in recent years, formed an ill colony that can not be ignored.At present, China has entered the diabetes outbreak period, increases by 3000 of patients every day at least.The treatment of diabetes and complication thereof and prevent extremely urgent.
Although oral antidiabetic drug is of a great variety on the market, up to now, also there is not which kind of medicine to remain within the target zone for a long time with the HbAlc level of one's own with the type ii diabetes patient.This shows that the novel antidiabetic drug that exploitation has brand-new mechanism of action and preferable risk/beneficial ratio has become a vital task that needs to be resolved hurrily.
Summary of the invention
The object of the present invention is to provide a kind of hypoglycemic pharmaceutical composition.This pharmaceutical composition is after long term administration, and the curative effect aspect reduction post-prandial glycemia, fasting blood glucose level is very good, has obtained good hypoglycemic effect,
The object of the present invention is achieved like this:
A kind of hypoglycemic pharmaceutical composition is prepared from by following parts by weight of Chinese traditional medicine material: Folium Mori 14-18 part, Radix Puerariae 8-12 part, Radix Scrophulariae 8-12 part, Rhizoma Polygonati 8-12 part, Cortex Lycii 8-12 part, Cortex Phellodendri 10-15 part, Fructus Lycii 6-10 part, Radix Astragali 8-12 part, Rhizoma Atractylodis 6-10 part.
Preferably, described hypoglycemic pharmaceutical composition is prepared from by following parts by weight of Chinese traditional medicine material: 15 parts on Folium Mori, 10 parts of Radix Puerariaes, 10 parts of Radix Scrophulariaes, 10 parts of Rhizoma Polygonatis, 10 parts of Cortex Lycii, 12 parts of Cortex Phellodendris, 8 parts of Fructus Lyciis, 10 parts of the Radixs Astragali, 8 parts of Rhizoma Atractylodis.
Further preferably, described hypoglycemic pharmaceutical composition is oral liquid.
The preparation method of the Chinese medicine oral liquid that the present invention relates to comprises the steps:
(1) gets the above-mentioned Chinese crude drug of recipe quantity, clean roguing, dry, be ground into granule;
(2) more above-mentioned graininess medical material is added water and cover powder 2cm, soak 1-1.2h, pull medical material out and put multi-functional extraction and decoct with water secondary in irritating, add up the water that medical material 8-12 doubly measures for the first time, decoct 2h, get decocting liquid, filter, add up the water that medical material 8-10 doubly measures for the second time, decoct 2h, get twice decocting liquid and merge, filter, relative density is 1.25 concentrated solution when being concentrated into 90 ℃;
(3) concentrated solution is put 0-5 ℃ of deepfreeze 24h, cold preservation liquid is added 0.3% filter aid kieselguhr, filter, the filtrate reconcentration contains 2-2.5g crude drug amount to every milliliter, stirs, and puts 0-5 ℃ of deepfreeze 24h, and cold preservation liquid is filtered, and gets oral liquid.
Usage and dosage: the patient takes 30ml every day, sooner or later respectively once.
According to the record of Chinese medicine historical data, the pharmacologically active of above-mentioned Chinese crude drug is as follows:
Folium Mori: have dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, suppressing liver-YANG, liver heat removing and eyesight improving, the effect of cooling blood for hemostasis.Select the dried leaves of Moraceae Moraceae plant Mulberry Morus alba L. for use.
Radix Puerariae: induce sweat and bring down a fever, promote the production of body fluid, rash, yang invigorating antidiarrheal.Be used for fever caused by exogenous pathogens headache, hypertension neck pain, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, have loose bowels.Be selected from the dry root of legume pueraria lobata Pueraria lobata (Willd.) Ohwi, i.e. Herba Gelsemii Elegantis.
Radix Scrophulariae: clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing.Cure mainly pathogenic warmth and join the army, the pericardium that caves in, maculae caused by violent heat pathogen, constipation, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus are hindered in consumption of YIN caused by febrile disease, crimson tongue excessive thirst, Tianjin.Be selected from the dry root of dicotyledon Scrophulariaceae Scrophulariaceae Radix Scrophulariae Scrophularia ningpoensisHemsl..
Rhizoma Polygonati: nourishing kidney lung moistening, invigorating the spleen and replenishing QI.Cure mainly deficiency of YIN chronic cough; The xeropulmonary cough; Insufficiency of the spleen weak; The lack of appetite xerostomia; Quench one's thirst; The deficiency of the kidney soreness of the waist and knees; Impotence and seminal emission; The tinnitus order is dark; Early whitening of beard and hair; The empty win of body is thin; Wind favus disease.Be selected from the dry rhizome of liliaceous plant Yunnan Rhizoma Polygonati (Polygonatum kingianum Coll. et Hemsl.).
Cortex Lycii: removing heat from blood is except steaming the lung heat clearing pathogenic fire reducing.Be used for deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, cough due to lung-heat, spitting of blood, epistaxis.Select the root bark of matrimony vine of solanaceae plant Lycium chinense Mill. for use.
Cortex Phellodendri: heat clearing and damp drying, eliminating fire and detoxication is except the hectic fever due to YIN-deficiency clearind deficient heat.Be used for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Be selected from the dry bark of rutaceae wampee or Cortex Phellodendri.
Fructus Lycii: the treating the liver kidney yin is lost, replenishing vital essence to improve eyesight.Be used for the asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, impotence and seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, blurred vision is not clear.
The Radix Astragali: have benefiting QI for strengthening the superficies, arresting sweating to take off, hold in the palm the effect of skin ulcer granulation promoting, inducing diuresis to remove edema admittedly.It is weak to be used for the treatment of the deficiency of vital energy, sinking of QI of middle-JIAO, and the chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, carbuncle is difficult bursts, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.The invigorating middle warmer of Radix Astragali Preparata QI invigorating is given birth to consolidating superficial resistance holder skin ulcer.
Rhizoma Atractylodis: drying damp and strengthening spleen, expelling wind and cold makes eye bright.Be used for distension and fullness in the abdomen, the edema of having loose bowels, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia.
According to animal test results as seen, Chinese medicine composition of the present invention is after long term administration, curative effect aspect reduction post-prandial glycemia, fasting blood glucose level is very good, obtained good hypoglycemic effect, good hypoglycemic effect is indicating that pharmaceutical composition of the present invention will produce active influence for the prognosis of diabetes, has brought hope for the recovery from illness of diabetics.
The specific embodiment
Below be specific embodiments of the invention, technical scheme of the present invention is done further the description, but protection scope of the present invention is not limited to these embodiment.Every do not deviate from the change of the present invention design or be equal to substitute include within protection scope of the present invention.
The preparation of embodiment 1 Chinese medicine oral liquid
Crude drug prescription: Folium Mori 150g, Radix Puerariae 100g, Radix Scrophulariae 100g, Rhizoma Polygonati 100g, Cortex Lycii 100g, Cortex Phellodendri 120g, Fructus Lycii 80g, Radix Astragali 100g, Rhizoma Atractylodis 80g.
Oral liquor:
(1) gets the above-mentioned Chinese crude drug of recipe quantity, clean roguing, dry, be ground into granule;
(2) more above-mentioned graininess medical material is added water and cover powder 2cm, soak 1-1.2h, pull medical material out and put multi-functional extraction and decoct with water secondary in irritating, add up the water of 10 times of amounts of medical material for the first time, decoct 2h, get decocting liquid, filter, add up the water of 10 times of amounts of medical material for the second time, decoct 2h, get twice decocting liquid and merge, filter, relative density is 1.25 concentrated solution when being concentrated into 90 ℃;
(3) concentrated solution is put 2 ℃ of deepfreeze 24h, cold preservation liquid is added 0.3% filter aid kieselguhr, filter, the filtrate reconcentration contains 2g crude drug amount to every milliliter, stirs, and puts 2 ℃ of deepfreeze 24h, and cold preservation liquid is filtered, and gets oral liquid.
The preparation of embodiment 2 Chinese medicine oral liquid
Crude drug prescription: Folium Mori 180g, Radix Puerariae 120g, Radix Scrophulariae 80g, Rhizoma Polygonati 120g, Cortex Lycii 80g, Cortex Phellodendri 100g, Fructus Lycii 100g, Radix Astragali 120g, Rhizoma Atractylodis 100g.
Oral liquor:
(1) gets the above-mentioned Chinese crude drug of recipe quantity, clean roguing, dry, be ground into granule;
(2) more above-mentioned graininess medical material is added water and cover powder 2cm, soak 1-1.2h, pull medical material out and put multi-functional extraction and decoct with water secondary in irritating, add up the water of 8 times of amounts of medical material for the first time, decoct 2h, get decocting liquid, filter, add up the water of 8 times of amounts of medical material for the second time, decoct 2h, get twice decocting liquid and merge, filter, relative density is 1.25 concentrated solution when being concentrated into 90 ℃;
(3) concentrated solution is put 4 ℃ of deepfreeze 24h, cold preservation liquid is added 0.3% filter aid kieselguhr, filter, the filtrate reconcentration contains 2g crude drug amount to every milliliter, stirs, and puts 4 ℃ of deepfreeze 24h, and cold preservation liquid is filtered, and gets oral liquid.
The preparation of embodiment 3 Chinese medicine oral liquid
Crude drug prescription: Folium Mori 150g, Radix Puerariae 80g, Radix Scrophulariae 120g, Rhizoma Polygonati 120g, Cortex Lycii 120g, Cortex Phellodendri 100g, Fructus Lycii 100g, Radix Astragali 100g, Rhizoma Atractylodis 60g.
Oral liquor:
(1) gets the above-mentioned Chinese crude drug of recipe quantity, clean roguing, dry, be ground into granule;
(2) more above-mentioned graininess medical material is added water and cover powder 2cm, soak 1-1.2h, pull medical material out and put multi-functional extraction and decoct with water secondary in irritating, add up the water of 12 times of amounts of medical material for the first time, decoct 2h, get decocting liquid, filter, add up the water of 10 times of amounts of medical material for the second time, decoct 2h, get twice decocting liquid and merge, filter, relative density is 1.25 concentrated solution when being concentrated into 90 ℃;
(3) concentrated solution is put 2 ℃ of deepfreeze 24h, cold preservation liquid is added 0.3% filter aid kieselguhr, filter, the filtrate reconcentration contains 2.5g crude drug amount to every milliliter, stirs, and puts 2 ℃ of deepfreeze 24h, and cold preservation liquid is filtered, and gets oral liquid.
Embodiment 4 Chinese medicine compositions of the present invention are to the effect research of diabetes model rat
Body weight 160～180gSD rat, male and female half and half are fed earlier with high-sugar-fat-diet (albumen select matter 5%, carbohydrate 60% wherein sucrose is 30%, wherein to refine Adeps Sus domestica be 30% to fat 32%) after 4 weeks rat fasting 18h.Lumbar injection 0.6% streptozotocin (STZ) 30mg/kg, STZ is dissolved in PH4.0, and in the 0.1mol/L citric acid-sodium citrate buffer, each dose uses up in 10min.Blank group rats by intraperitoneal injection equal-volume citric acid-sodium citrate buffer, the normal raising.Docking is got blood and is surveyed whole blood sugar after 5 days, is the modeling success with blood glucose value level＞10.0mmol/L person.
Modeling success rat is divided into following respectively group at random according to blood sugar level: model control group, positive control drug group, test group, 15 every group, irritate stomach every day twice (sooner or later respectively once), irritate stomach fasting in preceding 8 hours, give feedstuff at once, continuous 10 weeks behind the filling stomach.Each is organized rat and irritates stomach according to the dosage of table 1 and tried thing.
Table 1 is respectively organized the mice mode of feeding
| Group | Irritate stomach thing and dosage |
| Model control group | Isopyknic normal saline |
| Positive controls | 5mg/(kg.d) miglitol |
| Test group | The Chinese medicine oral liquid of the 8ml/kg/d embodiment of the invention 1 preparation |
After modeling success rat random packet, according to dosage gastric infusion in continuous 10 weeks, is normally raised.All rats are respectively at getting tail vein detection fasting glucose, feed back 2h blood glucose before treating and after the treatment end.
No matter show according to the experimental result of table 2, be fasting glucose or 2h blood glucose after the meal, test group and model group have significant difference (
P＜0.05).In addition, the hypoglycemic effect of test group is better than positive controls, but with positive controls do not have significant difference (
P＞0.05).Statistical analysis according to this result of the test can draw, and Chinese medicine composition of the present invention has comparatively desirable blood sugar decreasing effect.
The influence of each group of table 2 2h blood glucose to the diabetes rat fasting glucose with after taking food relatively
Compare * with model control group
P＜0.05, * *
P＜0.01.
Claims (2)
1. a hypoglycemic pharmaceutical composition is characterized in that being prepared from by following parts by weight of Chinese traditional medicine material: 15 parts on Folium Mori, 10 parts of Radix Puerariaes, 10 parts of Radix Scrophulariaes, 10 parts of Rhizoma Polygonatis, 10 parts of Cortex Lycii, 12 parts of Cortex Phellodendris, 8 parts of Fructus Lyciis, 10 parts of the Radixs Astragali, 8 parts of Rhizoma Atractylodis.
2. hypoglycemic pharmaceutical composition as claimed in claim 1, it is characterized in that: described pharmaceutical composition is oral liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210034678 CN102526484B (en) | 2012-02-16 | 2012-02-16 | Medicinal composition for decreasing blood sugar |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210034678 CN102526484B (en) | 2012-02-16 | 2012-02-16 | Medicinal composition for decreasing blood sugar |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102526484A CN102526484A (en) | 2012-07-04 |
| CN102526484B true CN102526484B (en) | 2013-08-14 |
Family
ID=46335304
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201210034678 Active CN102526484B (en) | 2012-02-16 | 2012-02-16 | Medicinal composition for decreasing blood sugar |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102526484B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103598590B (en) * | 2013-11-25 | 2015-05-20 | 重庆市中药研究院 | Traditional Chinese medicine composition for decreasing blood sugar and application thereof |
| CN106266570A (en) * | 2016-09-20 | 2017-01-04 | 陈亚平 | A kind of Chinese medicine composition of assistant hypoglycemic and preparation method thereof |
| CN114732869A (en) * | 2021-01-07 | 2022-07-12 | 吴月英 | Chinese medicinal composition for treating diabetes and preparation method thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1103598C (en) * | 1998-02-12 | 2003-03-26 | 王钢柱 | Chinese medicine for treating diabetes and preparation method therefor |
| CN1075735C (en) * | 1999-09-07 | 2001-12-05 | 阎纯义 | Compound diabetes-treating Chinese medicine preparation |
| CN1201776C (en) * | 2002-10-24 | 2005-05-18 | 河北以岭医药研究院有限公司 | Medicines composition for treating diabetes and its prepn |
| CN1201783C (en) * | 2002-12-11 | 2005-05-18 | 王书轩 | Oral liquid for replenishing vital essence, removing dryness and reducing glucose and preparation process thereof |
-
2012
- 2012-02-16 CN CN 201210034678 patent/CN102526484B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN102526484A (en) | 2012-07-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100353983C (en) | Chinese medicine preparation for reducing sugar | |
| CN102274429B (en) | Chinese medicinal composition for treating diabetes | |
| CN103690783B (en) | Chinese medicine preparation being used for the treatment of diabetes and preparation method thereof | |
| CN103749822B (en) | A kind of fruit of glossy privet hypertension and hyperlipemia health protection tea and preparation method thereof | |
| CN103520572A (en) | Traditional Chinese composition used for treating atopic dermatitis as well as preparation method of composition | |
| CN103223111B (en) | Traditional Chinese medicine composition for treating diabetic nephropathy and preparation method thereof | |
| CN103933346B (en) | A kind of compound for reducing blood suger and preparation method thereof | |
| CN102526484B (en) | Medicinal composition for decreasing blood sugar | |
| CN104083640B (en) | Traditional Chinese medicinal composition for treating diabetes mellitus and preparation method thereof | |
| CN103749819B (en) | Fructus Corni health protection tea of a kind of hypoglycemic and preparation method thereof | |
| CN102885975A (en) | Traditional Chinese medicine composition for treating diabetes mellitus | |
| CN105031454A (en) | Medicine for treating pulmonary tuberculosis | |
| CN104906430A (en) | Traditional Chinese medicine preparation for treating xerophthalmia and preparation method thereof | |
| CN104042956A (en) | Medicament for treating diabetes and preparation method thereof | |
| CN101406673B (en) | Oral liquid special for treating vital myocarditis of children | |
| CN101024037A (en) | Medicine for treating non-insulin-depending type diabetes | |
| CN102335249A (en) | Oral capsule for treating II-type diabetes | |
| CN105327181A (en) | Medicine composition for treating diabetes | |
| CN108853340A (en) | A kind of Chinese medicine of nourishing the liver and kidney and preparation method thereof | |
| CN104173975A (en) | Traditional Chinese medicine composition for treating diabetes mellitus | |
| CN103989940A (en) | Traditional Chinese medicine composition for treating diabetes mellitus | |
| CN104223062B (en) | Root bark of Chinese wolf-berry health care oral liquid of a kind of reducing pressure and sugar and preparation method thereof | |
| CN105878732A (en) | Traditional Chinese medicine for curing diabetes and preparation method thereof | |
| CN105381273A (en) | Medicine composition for treating diabetes and application thereof | |
| CN104667241A (en) | Traditional Chinese medicine preparation for treating extrahepatic phosphorus metabolism disease and preparation method of preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: CUI XINMING Free format text: FORMER OWNER: XU CONGYU Effective date: 20130327 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 276017 LINYI, SHANDONG PROVINCE TO: 266200 QINGDAO, SHANDONG PROVINCE |
|
| TA01 | Transfer of patent application right |
Effective date of registration: 20130327 Address after: 266200, No. seven, 179 village, Wenquan Town, Jimo, Shandong, Qingdao Applicant after: Cui Xinming Address before: 276017 A302 building, Linyi hi tech Industrial Development Zone, Shandong, China Applicant before: Xu Congyu |
|
| C53 | Correction of patent for invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Su Yu Inventor after: Zhao Longmei Inventor before: Su Jingrong |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: SU JINGRONG TO: SU YU ZHAO LONGMEI |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: QIDONG SANJIANG CONSTRUCTION MACHINERY CO., LTD. Free format text: FORMER OWNER: CUI XINMING Effective date: 20140725 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 266200 QINGDAO, SHANDONG PROVINCE TO: 226200 NANTONG, JIANGSU PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20140725 Address after: 226200 Nanhai Road, Binhai Industrial Park, Nantong, Jiangsu, Qidong Patentee after: Qidong Sanjiang Construction Machinery Co., Ltd. Address before: 266200, No. seven, 179 village, Wenquan Town, Jimo, Shandong, Qingdao Patentee before: Cui Xinming |