CN102488830B - 一种降血糖的药物组合物 - Google Patents
一种降血糖的药物组合物 Download PDFInfo
- Publication number
- CN102488830B CN102488830B CN 201110427179 CN201110427179A CN102488830B CN 102488830 B CN102488830 B CN 102488830B CN 201110427179 CN201110427179 CN 201110427179 CN 201110427179 A CN201110427179 A CN 201110427179A CN 102488830 B CN102488830 B CN 102488830B
- Authority
- CN
- China
- Prior art keywords
- radix
- pharmaceutical composition
- medicine
- blood sugar
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 13
- 239000008280 blood Substances 0.000 title abstract description 20
- 210000004369 blood Anatomy 0.000 title abstract description 20
- 235000000346 sugar Nutrition 0.000 title abstract description 7
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 4
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 4
- 235000008434 ginseng Nutrition 0.000 claims abstract description 4
- 238000002360 preparation method Methods 0.000 claims description 13
- 230000002218 hypoglycaemic effect Effects 0.000 claims description 9
- 239000000706 filtrate Substances 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 241000208340 Araliaceae Species 0.000 claims description 3
- XOJVHLIYNSOZOO-SWOBOCGESA-N Arctiin Chemical compound C1=C(OC)C(OC)=CC=C1C[C@@H]1[C@@H](CC=2C=C(OC)C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)=CC=2)C(=O)OC1 XOJVHLIYNSOZOO-SWOBOCGESA-N 0.000 claims description 3
- 206010013786 Dry skin Diseases 0.000 claims description 3
- 239000009636 Huang Qi Substances 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 7
- 238000000034 method Methods 0.000 abstract description 6
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 230000008569 process Effects 0.000 abstract description 3
- 244000061520 Angelica archangelica Species 0.000 abstract 1
- 241000045403 Astragalus propinquus Species 0.000 abstract 1
- 241000132011 Atractylodes lancea Species 0.000 abstract 1
- 244000223760 Cinnamomum zeylanicum Species 0.000 abstract 1
- 240000004670 Glycyrrhiza echinata Species 0.000 abstract 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 abstract 1
- 235000001287 Guettarda speciosa Nutrition 0.000 abstract 1
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 244000018795 Prunus mume Species 0.000 abstract 1
- 235000011158 Prunus mume Nutrition 0.000 abstract 1
- 244000046146 Pueraria lobata Species 0.000 abstract 1
- 235000010575 Pueraria lobata Nutrition 0.000 abstract 1
- 241000405414 Rehmannia Species 0.000 abstract 1
- 235000006533 astragalus Nutrition 0.000 abstract 1
- 235000021028 berry Nutrition 0.000 abstract 1
- 235000017803 cinnamon Nutrition 0.000 abstract 1
- 230000035876 healing Effects 0.000 abstract 1
- 229940010454 licorice Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 34
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 30
- 239000008103 glucose Substances 0.000 description 30
- 235000001727 glucose Nutrition 0.000 description 16
- 229940079593 drug Drugs 0.000 description 10
- 201000001421 hyperglycemia Diseases 0.000 description 7
- 206010012601 diabetes mellitus Diseases 0.000 description 6
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 6
- 210000004185 liver Anatomy 0.000 description 6
- 239000002552 dosage form Substances 0.000 description 5
- 241000700159 Rattus Species 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 102000004877 Insulin Human genes 0.000 description 3
- 108090001061 Insulin Proteins 0.000 description 3
- 235000013339 cereals Nutrition 0.000 description 3
- 239000004744 fabric Substances 0.000 description 3
- 229940125396 insulin Drugs 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 235000012054 meals Nutrition 0.000 description 3
- 206010062198 microangiopathy Diseases 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 201000001320 Atherosclerosis Diseases 0.000 description 2
- 206010063547 Diabetic macroangiopathy Diseases 0.000 description 2
- 206010022998 Irritability Diseases 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 239000007963 capsule composition Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 206010036067 polydipsia Diseases 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- BOVGTQGAOIONJV-BETUJISGSA-N 1-[(3ar,6as)-3,3a,4,5,6,6a-hexahydro-1h-cyclopenta[c]pyrrol-2-yl]-3-(4-methylphenyl)sulfonylurea Chemical compound C1=CC(C)=CC=C1S(=O)(=O)NC(=O)NN1C[C@H]2CCC[C@H]2C1 BOVGTQGAOIONJV-BETUJISGSA-N 0.000 description 1
- 206010006100 Bradykinesia Diseases 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 206010019468 Hemiplegia Diseases 0.000 description 1
- 206010020710 Hyperphagia Diseases 0.000 description 1
- 208000006083 Hypokinesia Diseases 0.000 description 1
- 206010054805 Macroangiopathy Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 208000010513 Stupor Diseases 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229940100389 Sulfonylurea Drugs 0.000 description 1
- 241000282894 Sus scrofa domesticus Species 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000003472 antidiabetic agent Substances 0.000 description 1
- 210000000709 aorta Anatomy 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 210000001841 basilar artery Anatomy 0.000 description 1
- 210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 229940099352 cholate Drugs 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 210000004351 coronary vessel Anatomy 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 210000002969 egg yolk Anatomy 0.000 description 1
- 230000001037 epileptic effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 210000002683 foot Anatomy 0.000 description 1
- 239000004459 forage Substances 0.000 description 1
- 230000005714 functional activity Effects 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 229960000346 gliclazide Drugs 0.000 description 1
- 150000002304 glucoses Chemical class 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 210000003701 histiocyte Anatomy 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000003914 insulin secretion Effects 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 210000004153 islets of langerhan Anatomy 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 238000012503 pharmacopoeial method Methods 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 208000022530 polyphagia Diseases 0.000 description 1
- 230000000291 postprandial effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 210000002254 renal artery Anatomy 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- YROXIXLRRCOBKF-UHFFFAOYSA-N sulfonylurea Chemical class OC(=N)N=S(=O)=O YROXIXLRRCOBKF-UHFFFAOYSA-N 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000011285 therapeutic regimen Methods 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 210000003371 toe Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
- 239000000304 virulence factor Substances 0.000 description 1
- 230000007923 virulence factor Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
组别 | FPG | 2hPG |
正常组 | 5.35±0.21 | 7.89±0.19 |
模拟组 | 20.21±4.11 | 26.19±4.91 |
对照药物组 | 7.46±1.07 | 8.12±0.87 |
本发明药物组 | 6.89±0.28 | 7.64±0.39 |
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 201110427179 CN102488830B (zh) | 2011-12-20 | 2011-12-20 | 一种降血糖的药物组合物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 201110427179 CN102488830B (zh) | 2011-12-20 | 2011-12-20 | 一种降血糖的药物组合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102488830A CN102488830A (zh) | 2012-06-13 |
CN102488830B true CN102488830B (zh) | 2013-06-05 |
Family
ID=46180728
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 201110427179 Expired - Fee Related CN102488830B (zh) | 2011-12-20 | 2011-12-20 | 一种降血糖的药物组合物 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN102488830B (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102845750A (zh) * | 2012-09-19 | 2013-01-02 | 无锡市天赐康生物科技有限公司 | 一种具有降血糖功能的保健食品及其制备方法 |
CN103652157B (zh) * | 2013-10-18 | 2016-03-30 | 梅州广通制药有限公司 | 一种速溶分子保健茶 |
CN105685851A (zh) * | 2016-02-23 | 2016-06-22 | 毛德英 | 一种海参胶囊及其制备方法 |
CN108634320A (zh) * | 2018-05-16 | 2018-10-12 | 北京秦凰达同生物科技有限公司 | 针对三高人群的膳食营养补充剂及其制备方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1895400A (zh) * | 2006-06-16 | 2007-01-17 | 芮育健 | 黄芪白芍葛根补肾益气治疗糖尿病的新方法 |
-
2011
- 2011-12-20 CN CN 201110427179 patent/CN102488830B/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN102488830A (zh) | 2012-06-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101708295B (zh) | 一种治疗糖尿病的中药制剂及其制备方法 | |
CN103083531B (zh) | 治疗糖尿病的药物 | |
CN103566350B (zh) | 一种具有降血糖作用的药物组合物 | |
CN102727706A (zh) | 预防和治疗糖尿病的组合物 | |
CN102205095A (zh) | 一种具有辅助降血糖功能的药物组合物 | |
CN102488830B (zh) | 一种降血糖的药物组合物 | |
CN103417846B (zh) | 一种降糖的中药组合物及其制备方法 | |
CN101647857A (zh) | 治疗***的中药组合物及其制备方法 | |
CN100493572C (zh) | 一种治疗糖尿病的药物组合物 | |
CN102488846B (zh) | 一种治疗糖尿病的药物组合物 | |
CN104815166A (zh) | 一种治疗糖尿病的中药组合物及其制备和应用 | |
CN102861201A (zh) | 一种治疗糖尿病的药物组合物及其制备方法 | |
CN101279034B (zh) | 一种内服和外用结合治疗糖尿病的组合中药及制备方法 | |
CN102743646B (zh) | 一种检验及预防糖尿病的药物组合物 | |
CN103007159B (zh) | 校正胰岛功能的中药制剂 | |
CN105125885B (zh) | 一种用于防治糖尿病的中药组合物及其制备方法 | |
CN101745048B (zh) | 一种治疗ⅱ型糖尿病与抗衰老的药物 | |
CN102018852A (zh) | 参连消渴降糖胶囊及制作工艺 | |
CN103566349B (zh) | 一种治疗高血糖高血脂的药物组合物 | |
CN103520684B (zh) | 一种降血糖的中药复合物 | |
CN103536879B (zh) | 一种治疗糖尿病的药物组合物以及制备方法 | |
CN103393938B (zh) | 一种降血糖的中药组合物 | |
CN108686094A (zh) | 一种降血糖的中药及其制备方法 | |
CN103550335A (zh) | 一种改善肝功能的中药组合物 | |
CN102430040A (zh) | 一种治疗糖尿病的药物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: RUDONG XINDIAN FARMLAND IRRIGATION AND DRAINAGE SE Free format text: FORMER OWNER: SONG BINGHONG Effective date: 20150113 |
|
C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 276000 LINYI, SHANDONG PROVINCE TO: 226400 NANTONG, JIANGSU PROVINCE |
|
TR01 | Transfer of patent right |
Effective date of registration: 20150113 Address after: 226400 Jiangsu Nantong County, Rudong province new town neighborhood committee Patentee after: Rudong Xin County farm irrigation and drainage Service Co., Ltd. Address before: 276000 health center of Linyi people's Hospital of Shandong Province Patentee before: Song Binghong |
|
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130605 Termination date: 20161220 |
|
CF01 | Termination of patent right due to non-payment of annual fee |