CN102488755B - Fishing Chinese herbal composition capable of inhibiting germs and preparation method thereof - Google Patents
Fishing Chinese herbal composition capable of inhibiting germs and preparation method thereof Download PDFInfo
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Abstract
The invention provides a fishing Chinese herbal composition capable of inhibiting germs and a preparation method thereof. The Chinese herbal composition mainly comprises radix astragali, rheum officinale, magnolia cortex, isatis root, licorice and dandelion and is prepared by uniformly mixing 30.7 to 40.7 parts by weight of radix astragali, 15.4 to 26.4 parts by weight of rheum officinale, 2.1 to 12.1 parts by weight of magnolia cortex, 2.1 to 12.1 parts by weight of isatis root, 9.3 to 19.3 parts by weight of licorice and 9.3 to 19.3 parts by weight of dandelion. The fishing Chinese herbal composition uses traditional Chinese medicines reasonably, has the effects of nourishing deficiency, strengthening body resistance, adjusting yin and yang, clearing heat, removing toxins, inhibiting bacteria and eliminating inflammation, can improve immunity of fishes and shrimps, substantially enhances capability of fishes and shrimps in resisting germs so as to effectively protect individual fish and shrimp and has the advantages of a nontoxic composition, mild performance, no generation of residues in fishes and shrimps, no drug resistance and capacity of being effectively degraded by organisms; the preparation method is simple, costs little and is suitable for scale industrial production.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and preparation method thereof, especially a kind of for antiviral fishing Chinese medicine composition and preparation method thereof.
Background technology
Along with the developing green veterinary drug, ensure that the cry of human health grows to even greater heights, antibiotic abuse has caused worldwide extensive concern to the negative effect that aquaculture production and ecological environment cause.Therefore, many countries and international organization make laws one after another, rules are forbidden or limit the use of some medicines, and make a series of regulation aspect imports trade, as sulfonamides, quinolones.The U.S. has also promulgated " federal food drug and cosmetic act safety law ", require again each medicinesafety to be made an appraisal, and the application of modern Chinese medicine in the fishery cultivating diseases prevention and treatment, not only can effectively treat disease, and Chinese herbal medicine belongs to pure natural medical, drug residue is low, can effectively solve the drug residue problem.And Chinese herbal medicine belongs to pure natural substance, and drug residue is low, can effectively solve the drug residue problem.Simultaneously, Chinese medicine has the characteristics of " determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs ", and herbal medicine can significantly strengthen the body constitution of animal after using, and improves immunity and the disease-resistant level of body, can reduce medication.
Select multiple Chinese herbal medicine with different pharmacological actions to screen prescription, can obtain the outstanding effect of drug effect complementation, curative effect enhancing, and can reduce to a certain extent the untoward reaction when respectively distinguishing the flavor of the use of Chinese medicine single dose, have more in actual use advantage.Given this, research and development one class is used for antiviral fishing Chinese medicine composition, has very important production practices meaning.
Summary of the invention
It is a kind of for antiviral fishing Chinese medicine composition that technical problem to be solved by this invention is to provide.
It is above-mentioned for the preparation method of antiviral fishing with Chinese medicine composition that another technical problem to be solved by this invention is to provide.
For solving the problems of the technologies described above, technical scheme of the present invention is:
A kind of for antiviral fishing Chinese medicine composition, mainly formed by the Radix Astragali, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Radix Isatidis, Radix Glycyrrhizae and Herba Taraxaci, count Radix Astragali 30.7-40.7 part, Radix Et Rhizoma Rhei 15.4-26.4 part, Cortex Magnoliae Officinalis 2.1-12.1 part, Radix Isatidis 2.1-12.1 part, Radix Glycyrrhizae 9.3-19.3 part, Herba Taraxaci 9.3-19.3 part by its parts by weight.
Preferably, above-mentioned for antiviral fishing Chinese medicine composition, by its parts by weight Radix Astragali 33-39 part, Radix Et Rhizoma Rhei 16-25 part, Cortex Magnoliae Officinalis 4-9 part, Radix Isatidis 8-11 part, Radix Glycyrrhizae 12-17 part, Herba Taraxaci 12-16 part.
Preferably, above-mentioned for antiviral fishing Chinese medicine composition, by 35 parts of its parts by weight Radixs Astragali, 21 parts of Radix Et Rhizoma Rhei, 8 parts of Cortex Magnoliae Officinalis, 10 parts of Radix Isatidis, 14 parts, Radix Glycyrrhizae, 14 parts of Herba Taraxacis.
Preferably, above-mentioned for antiviral fishing Chinese medicine composition, also comprise phagostimulant, count Radix Astragali 30.7-40.7 part, Radix Et Rhizoma Rhei 15.4-26.4 part, Cortex Magnoliae Officinalis 2.1-12.1 part, Radix Isatidis 2.1-12.1 part, Radix Glycyrrhizae 9.3-19.3 part, Herba Taraxaci 9.3-19.3 part, phagostimulant 1-2 part by its parts by weight.
Preferably, above-mentioned for antiviral fishing Chinese medicine composition, described phagostimulant is allicin powder or betanin.
Above-mentioned for the preparation method of antiviral fishing with Chinese medicine composition, concrete preparation process is as follows:
(1) taking by weight Radix Astragali 30.7-40.7 part, Radix Et Rhizoma Rhei 15.4-26.4 part, Cortex Magnoliae Officinalis 2.1-12.1 part, Radix Isatidis 2.1-12.1 part, Radix Glycyrrhizae 9.3-19.3 part, Herba Taraxaci 9.3-19.3 part is raw material;
(2) each flavor Chinese medicine is cleaned, dried, micronizing is to 30-60 μ m, mix homogeneously, and get final product.
Preferably, above-mentioned for the preparation method of antiviral fishing with Chinese medicine composition, concrete preparation process is as follows:
(1) taking by weight Radix Astragali 30.7-40.7 part, Radix Et Rhizoma Rhei 15.4-26.4 part, Cortex Magnoliae Officinalis 2.1-12.1 part, Radix Isatidis 2.1-12.1 part, Radix Glycyrrhizae 9.3-19.3 part, Herba Taraxaci 9.3-19.3 part, phagostimulant 1-2 part is raw material;
(2) each flavor Chinese medicine is cleaned, dried, micronizing is to 30-60 μ m, mix homogeneously, and get final product.
Preferably, above-mentioned for the preparation method of antiviral fishing with Chinese medicine composition, micronizing to 44 μ m in described step (2).
Above-mentionedly freely eat every day 2-3 time for adding described Chinese medicine composition to normal feedstuff in the ratio of 0.5-1.5 ‰ for the consumption of antiviral fishing with Chinese medicine composition.
The invention has the beneficial effects as follows:
Above-mentioned for antiviral fishing Chinese medicine composition, with the Chinese medicine reasonable formula, has the effect of holding up empty revisal, regulating negative and positive, heat-clearing and toxic substances removing, anti-inflammation, when improving the fish and shrimp immunocompetence, greatly improve its antiviral ability, thereby effectively protect fish and shrimp individual, and prescription is nontoxic, warm in nature and, can not produce residually in the fish and shrimp body, not produce drug resistance, can effectively be degraded by body; Its preparation method is simple, and cost is low, is fit to the needs that large-scale industrial is produced.
The specific embodiment
Below in conjunction with specific embodiment, technical scheme of the present invention is further described.
Embodiment 1
A kind ofly be comprised of the Radix Astragali, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Radix Isatidis, Radix Glycyrrhizae and Herba Taraxaci for antiviral fishing Chinese medicine composition, its weight is Radix Astragali 35kg, Radix Et Rhizoma Rhei 21kg, Cortex Magnoliae Officinalis 8kg, Radix Isatidis 10kg, Radix Glycyrrhizae 14kg, Herba Taraxaci 14kg.
Above-mentioned for the preparation method of antiviral fishing with Chinese medicine composition, concrete preparation process is as follows:
(1) taking Radix Astragali 35kg, Radix Et Rhizoma Rhei 21kg, Cortex Magnoliae Officinalis 8kg, Radix Isatidis 10kg, Radix Glycyrrhizae 14kg, Herba Taraxaci 14kg is raw material;
(2) each flavor Chinese medicine is cleaned, dried, micronizing, smashing fineness is 44 μ m, mix homogeneously, and get final product.
Embodiment 2
A kind ofly be comprised of the Radix Astragali, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Radix Isatidis, Radix Glycyrrhizae and Herba Taraxaci for antiviral fishing Chinese medicine composition, its weight is Radix Astragali 30.7kg, Radix Et Rhizoma Rhei 26.4kg, Cortex Magnoliae Officinalis 12.1kg, Radix Isatidis 2.1kg, Radix Glycyrrhizae 9.3kg, Herba Taraxaci 19.3kg.
Above-mentioned for the preparation method of antiviral fishing with Chinese medicine composition, concrete preparation process is as follows:
(1) taking Radix Astragali 30.7kg, Radix Et Rhizoma Rhei 26.4kg, Cortex Magnoliae Officinalis 12.1kg, Radix Isatidis 2.1kg, Radix Glycyrrhizae 9.3kg, Herba Taraxaci 19.3kg is raw material;
(2) each flavor Chinese medicine is cleaned, dried, micronizing, smashing fineness is 30 μ m, mix homogeneously, and get final product.
Embodiment 3
A kind ofly be comprised of the Radix Astragali, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Radix Isatidis, Radix Glycyrrhizae and Herba Taraxaci for antiviral fishing Chinese medicine composition, its weight is Radix Astragali 33kg, Radix Et Rhizoma Rhei 25kg, Cortex Magnoliae Officinalis 9kg, Radix Isatidis 8kg, Radix Glycyrrhizae 17kg, Herba Taraxaci 12kg.
Above-mentioned for the preparation method of antiviral fishing with Chinese medicine composition, concrete preparation process is as follows:
(1) taking Radix Astragali 33kg, Radix Et Rhizoma Rhei 25kg, Cortex Magnoliae Officinalis 9kg, Radix Isatidis 8kg, Radix Glycyrrhizae 17kg, Herba Taraxaci 12kg is raw material;
(2) each flavor Chinese medicine is cleaned, dried, micronizing, smashing fineness is 60 μ m, mix homogeneously, and get final product.
Embodiment 4
A kind ofly be comprised of the Radix Astragali, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Radix Isatidis, Radix Glycyrrhizae and Herba Taraxaci for antiviral fishing Chinese medicine composition, its weight is Radix Astragali 39kg, Radix Et Rhizoma Rhei 16kg, Cortex Magnoliae Officinalis 4kg, Radix Isatidis 11kg, Radix Glycyrrhizae 12kg, Herba Taraxaci 16kg.
Above-mentioned for the preparation method of antiviral fishing with Chinese medicine composition, concrete preparation process is as follows:
(1) taking Radix Astragali 39kg, Radix Et Rhizoma Rhei 16kg, Cortex Magnoliae Officinalis 4kg, Radix Isatidis 11kg, Radix Glycyrrhizae 12kg, Herba Taraxaci 16kg is raw material;
(2) each flavor Chinese medicine is cleaned, dried, micronizing, smashing fineness is 52 μ m, mix homogeneously, and get final product.
Embodiment 5
A kind ofly be comprised of the Radix Astragali, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Radix Isatidis, Radix Glycyrrhizae and Herba Taraxaci for antiviral fishing Chinese medicine composition, its weight is Radix Astragali 31kg, Radix Et Rhizoma Rhei 20kg, Cortex Magnoliae Officinalis 7kg, Radix Isatidis 6kg, Radix Glycyrrhizae 11kg, Herba Taraxaci 17kg.
Above-mentioned for the preparation method of antiviral fishing with Chinese medicine composition, concrete preparation process is as follows:
(1) taking Radix Astragali 31kg, Radix Et Rhizoma Rhei 20kg, Cortex Magnoliae Officinalis 7kg, Radix Isatidis 6kg, Radix Glycyrrhizae 11kg, Herba Taraxaci 17kg is raw material;
(2) each flavor Chinese medicine is cleaned, dried, micronizing, smashing fineness is 35 μ m, mix homogeneously, and get final product.
Embodiment 6
A kind of for antiviral fishing Chinese medicine composition, be comprised of the Radix Astragali, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Radix Isatidis, Radix Glycyrrhizae, Herba Taraxaci and betanin, its weight is Radix Astragali 40.7kg, Radix Et Rhizoma Rhei 15.4kg, Cortex Magnoliae Officinalis 2.1kg, Radix Isatidis 12.1kg, Radix Glycyrrhizae 19.3kg, Herba Taraxaci 9.3kg, betanin 1.5kg.
Above-mentioned for the preparation method of antiviral fishing with Chinese medicine composition, concrete preparation process is as follows:
(1) take the Radix Astragali, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Radix Isatidis, Radix Glycyrrhizae, Herba Taraxaci and betanin and form, its weight is that Radix Astragali 40.7kg, Radix Et Rhizoma Rhei 15.4kg, Cortex Magnoliae Officinalis 2.1kg, Radix Isatidis 12.1kg, Radix Glycyrrhizae 19.3kg, Herba Taraxaci 9.3kg, betanin 1.5kg are raw material;
(2) each flavor Chinese medicine is cleaned, dried, micronizing, smashing fineness is 47 μ m, mix homogeneously, and get final product.
Embodiment 7
A kind of for antiviral fishing Chinese medicine composition, be comprised of the Radix Astragali, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Radix Isatidis, Radix Glycyrrhizae, Herba Taraxaci and allicin powder, its weight is Radix Astragali 36kg, Radix Et Rhizoma Rhei 22kg, Cortex Magnoliae Officinalis 5kg, Radix Isatidis 4kg, Radix Glycyrrhizae 15kg, Herba Taraxaci 11kg, allicin powder 2kg.
Above-mentioned for the preparation method of antiviral fishing with Chinese medicine composition, concrete preparation process is as follows:
(1) taking Radix Astragali 36kg, Radix Et Rhizoma Rhei 22kg, Cortex Magnoliae Officinalis 5kg, Radix Isatidis 4kg, Radix Glycyrrhizae 15kg, Herba Taraxaci 11kg, allicin powder 2kg is raw material;
(2) each flavor Chinese medicine is cleaned, dried, micronizing, smashing fineness is 39 μ m,, mix homogeneously, and get final product.
Embodiment 8
A kind of for antiviral fishing Chinese medicine composition, be comprised of the Radix Astragali, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Radix Isatidis, Radix Glycyrrhizae, Herba Taraxaci and betanin, its weight is Radix Astragali 34kg, Radix Et Rhizoma Rhei 18kg, Cortex Magnoliae Officinalis 10kg, Radix Isatidis 5kg, Radix Glycyrrhizae 13kg, Herba Taraxaci 15kg, betanin 1kg.
Above-mentioned for the preparation method of antiviral fishing with Chinese medicine composition, concrete preparation process is as follows:
(1) taking Radix Astragali 34kg, Radix Et Rhizoma Rhei 18kg, Cortex Magnoliae Officinalis 10kg, Radix Isatidis 5kg, Radix Glycyrrhizae 13kg, Herba Taraxaci 15kg, betanin 1kg is raw material;
(2) each flavor Chinese medicine is cleaned, dried, micronizing, smashing fineness is 56 μ m,, mix homogeneously, and get final product.
Each amounts of components of the described Chinese crude drug of one of embodiment 1-8 is increased or reduces according to same ratio, and the parts by weight relation of each component of gained all belongs to protection scope of the present invention.
The described Chinese crude drug of embodiment 1-8 all meets " Chinese veterinary pharmacopoeia " version two ministerial standards in 2005.
The composition principle of Chinese medicine composition of the present invention is: Radix Astragali sweet in the mouth is warm in nature, is important QI invigorating Chinese medicine, has the effect of QI invigorating benefit table, detoxification granulation promoting, wherein contain the plurality of active ingredients such as polysaccharide, osajin and Saponin class, the energy anticoagulant reduces blood viscosity and coagulability, strengthen plasmin activity, relaxing smooth muscle, expansion lung, the heart, cerebrovascular reduce vascular resistance, improve blood circulation, especially improve microcirculation, thereby improve cardio-pulmonary function, promote pulmonary ventilation, organization aeration; The Radix Astragali can effectively reduce lipid peroxidation, reduces the generation of malonaldehyde, and the effect of stronger removing free radical is arranged, and the effective ingredient astragaloside of the Radix Astragali has the effects such as antiinflammatory, calmness, analgesia; The Radix Astragali and Cortex Magnoliae Officinalis, Radix Isatidis three flavor Chinese medicines have the tonify deficiency righting, regulate the effect of negative and positive; The Radix Astragali and Radix Glycyrrhizae, Radix Et Rhizoma Rhei, Herba Taraxaci four flavor Chinese medicines have the effect of heat-clearing and toxic substances removing, anti-inflammation.Full side's Synergistic, have the characteristics such as improve culturing fish and shrimp body nonspecific immunity function, improve its Anti-bacterium ability, dosage is little, be applicable to the control of fish and shrimp common bacteria virosis, especially adopt the described proportioning of embodiment 1, have the effect that significantly improves serum phenol oxidase (PO) vigor.
The clinical trial example:
The described Chinese medicine composition of test drug: embodiment 1
Clinical trial:
Clinical trial is done by plant in Tianjin, and the test prawn is available from Tianjin Wang Dingdi Aquatic Wholesale Market, and about specification 3.50g is confirmed not carry white spot syndrome virus after testing, buys back to support in aquarium temporarily afterwards.Throw something and feed day feedstuff 3 times changes water 1 time, quantity of exchanged water 1/2, continuous charge.
Test is divided into 5 groups, puts 100 tails in a suitable place to breed for every group, cultivates respectively in 500L fiberglass tank.EXPERIMENTAL DESIGN is divided into matched group and experimental group, and the medicine group is thrown something and fed and added the pharmaceutical chemistry material of the embodiment of the present invention 1 described Chinese medicine composition; Matched group is thrown something and fed and is not added the bait of any medicine.
Test the 3rd, 7,15,30 day after beginning, respectively random prawn 20 tails extraction hemolymphes, mensuration immune indexes serum phenol oxidase (PO) vigor of extracting from every group of test prawn.
The impact of table 1 Chinese medicine extract on prawn PO vigor
As can be seen from the above table, all add the experimental group of the embodiment of the present invention 1 described Chinese medicine compositions, and the PO vigor in prawn serum is all higher than un-added matched group, significant difference, and also additive capacity is larger, and the PO vigor in its prawn serum is higher.
PO has important immunologic function, pro-phenoloxidase system is present in the granular cell of prawn, can discharge pro-phenoloxidase (proPO) after activation, makes it to become the effect of activated PO performance antibody pathogen, in addition, PO has destruction to virus.
Above-mentioned with reference to embodiment to this a kind of detailed description of carrying out with Chinese medicine composition and preparation method thereof for antiviral fishing; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (4)
1. one kind is used for antiviral fishing Chinese medicine composition, it is characterized in that: formed by the Radix Astragali, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Radix Isatidis, Radix Glycyrrhizae and Herba Taraxaci, by its parts by weight Radix Astragali 33-39 part, Radix Et Rhizoma Rhei 16-25 part, Cortex Magnoliae Officinalis 4-9 part, Radix Isatidis 8-11 part, Radix Glycyrrhizae 12-17 part, Herba Taraxaci 12-16 part.
2. according to claim 1 for antiviral fishing Chinese medicine composition, it is characterized in that: by 35 parts of its parts by weight Radixs Astragali, 21 parts of Radix Et Rhizoma Rhei, 8 parts of Cortex Magnoliae Officinalis, 10 parts of Radix Isatidis, 14 parts, Radix Glycyrrhizae, 14 parts of Herba Taraxacis.
3. claimed in claim 1 for the preparation method of antiviral fishing with Chinese medicine composition, it is characterized in that: concrete preparation process is as follows:
(1) taking by weight Radix Astragali 33-39 part, Radix Et Rhizoma Rhei 16-25 part, Cortex Magnoliae Officinalis 4-9 part, Radix Isatidis 8-11 part, Radix Glycyrrhizae 12-17 part, Herba Taraxaci 12-16 part is raw material;
(2) each flavor Chinese medicine is cleaned, dried, micronizing is to 30-60 μ m, mix homogeneously, and get final product.
4. according to claim 3 for the preparation method of antiviral fishing with Chinese medicine composition, it is characterized in that: micronizing to 44 μ m in described step (2).
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| CN109528916A (en) * | 2018-11-30 | 2019-03-29 | 天门粤海饲料有限公司 | A kind of Chinese herbal medicine freshwater crayfish feed stuff disease-resistant additive |
| CN110013551A (en) * | 2019-05-21 | 2019-07-16 | 中国水产科学研究院珠江水产研究所 | A kind of fishing immersion immunity composite adjuvant and the preparation method and application thereof |
| CN114831995A (en) * | 2022-03-17 | 2022-08-02 | 天津农学院 | Fish microcystin antidote and use method thereof |
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| CN101002819A (en) * | 2006-01-16 | 2007-07-25 | 陈茜 | Compound dandelion dripping pills and its preparing method |
| CN101822717A (en) * | 2010-03-12 | 2010-09-08 | 山东大学威海分校 | Preparation of compound Chinese herbal medicine with function of promoting growth of cryprinus carpiod |
| CN101829211A (en) * | 2010-04-27 | 2010-09-15 | 武汉中博水产生物技术有限公司 | Fish compound traditional Chinese medicinal preparation and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101002819A (en) * | 2006-01-16 | 2007-07-25 | 陈茜 | Compound dandelion dripping pills and its preparing method |
| CN101822717A (en) * | 2010-03-12 | 2010-09-08 | 山东大学威海分校 | Preparation of compound Chinese herbal medicine with function of promoting growth of cryprinus carpiod |
| CN101829211A (en) * | 2010-04-27 | 2010-09-15 | 武汉中博水产生物技术有限公司 | Fish compound traditional Chinese medicinal preparation and preparation method thereof |
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