CN102432760A - 季胺型魔芋葡甘聚糖加合物及其制备方法和用途 - Google Patents
季胺型魔芋葡甘聚糖加合物及其制备方法和用途 Download PDFInfo
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- CN102432760A CN102432760A CN2011102753308A CN201110275330A CN102432760A CN 102432760 A CN102432760 A CN 102432760A CN 2011102753308 A CN2011102753308 A CN 2011102753308A CN 201110275330 A CN201110275330 A CN 201110275330A CN 102432760 A CN102432760 A CN 102432760A
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- Prior art keywords
- rhizoma amorphophalli
- amorphophalli glucomannan
- amido
- quaternary amine
- suction filtration
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- HVTICUPFWKNHNG-UHFFFAOYSA-N iodoethane Chemical compound CCI HVTICUPFWKNHNG-UHFFFAOYSA-N 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000002262 irrigation Effects 0.000 description 1
- 238000003973 irrigation Methods 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 208000017971 listlessness Diseases 0.000 description 1
- 235000015250 liver sausages Nutrition 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910001507 metal halide Inorganic materials 0.000 description 1
- 150000005309 metal halides Chemical class 0.000 description 1
- 229910001511 metal iodide Inorganic materials 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
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- 230000000050 nutritive effect Effects 0.000 description 1
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- JRKICGRDRMAZLK-UHFFFAOYSA-L persulfate group Chemical group S(=O)(=O)([O-])OOS(=O)(=O)[O-] JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
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- 238000012545 processing Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
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- 239000000376 reactant Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000006479 redox reaction Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000002522 swelling effect Effects 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical group FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 description 1
- 229910052718 tin Inorganic materials 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
- 238000002525 ultrasonication Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- GPPXJZIENCGNKB-UHFFFAOYSA-N vanadium Chemical compound [V]#[V] GPPXJZIENCGNKB-UHFFFAOYSA-N 0.000 description 1
- 235000008939 whole milk Nutrition 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Description
组别 | 饲料种类 |
普通对照组 | 混有炭黑的普通饲料 |
普通低剂量组 | 混有炭黑,含低剂量季胺型魔芋葡甘聚糖的饲料 |
普通高剂量组 | 混有炭黑,含高剂量季胺型魔芋葡甘聚糖的饲料 |
组别 | 饲料种类 |
肥胖对照组 | 混有炭黑的普通饲料 |
肥胖低剂量组 | 混有炭黑,含低剂量季胺型魔芋葡甘聚糖的饲料 |
肥胖高剂量组 | 混有炭黑,含高剂量季胺型魔芋葡甘聚糖的饲料 |
组别 | 灌胃药物 |
普通对照组 | 生理盐水 |
普通低剂量组 | 低剂量季胺型魔芋葡甘聚糖 |
普通高剂量组 | 高剂量季胺型魔芋葡甘聚糖 |
组别 | 灌胃药物 |
肥胖对照组 | 生理盐水 |
肥胖低剂量组 | 低剂量季胺型魔芋葡甘聚糖 |
肥胖高剂量组 | 高剂量季胺型魔芋葡甘聚糖 |
Claims (10)
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CN 201110275330 CN102432760B (zh) | 2011-09-16 | 2011-09-16 | 季胺型魔芋葡甘聚糖加合物及其制备方法和用途 |
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CN 201110275330 CN102432760B (zh) | 2011-09-16 | 2011-09-16 | 季胺型魔芋葡甘聚糖加合物及其制备方法和用途 |
Publications (2)
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CN102432760A true CN102432760A (zh) | 2012-05-02 |
CN102432760B CN102432760B (zh) | 2013-10-16 |
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CN (1) | CN102432760B (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106511271A (zh) * | 2016-10-21 | 2017-03-22 | 湖北工业大学 | 脂肪胺接枝魔芋葡甘聚糖载药纳米胶束及制备方法 |
CN110054434A (zh) * | 2019-06-05 | 2019-07-26 | 杭州中齐新材料科技有限公司 | 一种水下不分散混凝土用絮凝剂 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101117355A (zh) * | 2007-09-07 | 2008-02-06 | 武汉理工大学 | 氰乙基魔芋葡甘聚糖的制备方法 |
CN101497030A (zh) * | 2008-01-28 | 2009-08-05 | 西南科技大学 | 环境友好的氧化型疏水葡甘聚糖吸附材料及其制备方法 |
CA2760014A1 (en) * | 2009-05-27 | 2010-12-02 | Swetree Technologies Ab | A polymer made of a primary amine functionalized polymer and a hemicellulose |
CN102151557A (zh) * | 2011-04-29 | 2011-08-17 | 西南科技大学 | 高强度球形葡甘聚糖单宁复合型吸附材料及其制备方法 |
-
2011
- 2011-09-16 CN CN 201110275330 patent/CN102432760B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101117355A (zh) * | 2007-09-07 | 2008-02-06 | 武汉理工大学 | 氰乙基魔芋葡甘聚糖的制备方法 |
CN101497030A (zh) * | 2008-01-28 | 2009-08-05 | 西南科技大学 | 环境友好的氧化型疏水葡甘聚糖吸附材料及其制备方法 |
CA2760014A1 (en) * | 2009-05-27 | 2010-12-02 | Swetree Technologies Ab | A polymer made of a primary amine functionalized polymer and a hemicellulose |
CN102151557A (zh) * | 2011-04-29 | 2011-08-17 | 西南科技大学 | 高强度球形葡甘聚糖单宁复合型吸附材料及其制备方法 |
Non-Patent Citations (2)
Title |
---|
鲁俊,陈鹏等: "魔芋葡甘聚糖接枝聚二甲基二烯丙基氯化铵生物絮凝剂的制备", 《广东化工》 * |
鲁菲菲: "交联氨基魔芋葡甘聚糖的制备及对Cu(II)、Ni(II)、Cr(VI)的吸附研究", 《中国优秀硕士学位论文全文数据库 工程科技I辑》 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106511271A (zh) * | 2016-10-21 | 2017-03-22 | 湖北工业大学 | 脂肪胺接枝魔芋葡甘聚糖载药纳米胶束及制备方法 |
CN106511271B (zh) * | 2016-10-21 | 2019-05-03 | 湖北工业大学 | 脂肪胺接枝魔芋葡甘聚糖载药纳米胶束及制备方法 |
CN110054434A (zh) * | 2019-06-05 | 2019-07-26 | 杭州中齐新材料科技有限公司 | 一种水下不分散混凝土用絮凝剂 |
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