CN102397580A - Anti-adhesion fiber membrane with hemostasis and antibiosis functions and preparation method thereof - Google Patents
Anti-adhesion fiber membrane with hemostasis and antibiosis functions and preparation method thereof Download PDFInfo
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- CN102397580A CN102397580A CN2011103448711A CN201110344871A CN102397580A CN 102397580 A CN102397580 A CN 102397580A CN 2011103448711 A CN2011103448711 A CN 2011103448711A CN 201110344871 A CN201110344871 A CN 201110344871A CN 102397580 A CN102397580 A CN 102397580A
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Abstract
The invention discloses an anti-adhesion fiber membrane with hemostasis and antibiosis functions and a preparation method thereof. The preparation method comprises the following steps of: dissolving medicinal molecules into an organic or inorganic solvent to prepare a medicinal molecular solution; dissolving different high molecular materials into medicinal solutions of a hemostasis agent and an antibiosis agent respectively to prepare a high molecular solution; and performing electrostatic spinning on a mixed solution of organic high molecules and the hemostasis agent and a mixed solution of high molecules and the antibiosis agent to obtain a compound fiber material. In the invention, nanofiber is produced by using an electrostatic spinning technology; an organic high molecular solution and the medicinal molecules are mixed for electrostatic spinning to obtain the compound fiber material; by adjusting the high molecular material, the embedding amount and embedding rate of medicaments are increased, a fiber material which can keep the medicinal bioactivity and is used for controlling the release of different medicaments at different stages is prepared, and dual effects of preventing postoperative adhesion and postoperative infection can be achieved; and moreover, the entire preparation process is simple, has low cost, and has wide application prospect in the field of surgical operation.
Description
Technical field:
The present invention relates to anti fibrous membrane and preparation method thereof, relate in particular to a kind of anti fibrous membrane and preparation method thereof with hemostatic and antibacterial function.
Background technology:
It is domestic and international surgical field one of unsolved important difficult medical problem still so far that postoperative intestinal adhesion and part are inflamed.Adhesion not only can cause severe complications, and bad adhesion also is the one of the main reasons that complication obviously increases when performing the operation once more.For a long time, medical circle is being done a large amount of work aspect the research that prevents postoperative intestinal adhesion, but curative effect is not obvious.Along with developing rapidly of absorbable medical material, adopt special biomaterial to become the effective way that prevents tissue adhesion as spacer.
Ideal adherence preventing material should have excellent biological compatibility, suitable tissue adherence (need not sew up), fully wound coverage surface and have RT in enough bodies; Can degraded and absorbed and do not need second operation that it is taken out; Can effectively prevent the normal healing that adhesion forms does not influence wound again; Also should have certain mechanical strength and be convenient to implementation and operation etc.Electrostatic spinning is as fast-developing in recent years a kind of simple and effective processing technique for preparing non woven cloth in polymer; Because the product of its preparation has characteristics such as light weight, softness, high-specific surface area, high porosity, good permeability; Very suitable to post-operation adhesion preventing material, wound clad material, pharmaceutical carrier and tissue engineering bracket material, received the particularly great attention of biomedical materials field of field of materials.
Simultaneously, postoperative infection also is one of difficult problem that always perplexs China's medical circle.Patient must import a large amount of antibiosis and usually prevent potential infection after accepting surgical operation, special sanitary condition under-developed area in China.Patient tissue and the internal organs of whole body are all had certain side effect, so the focus zone is implanted into the diaphragm that carries antibiotic, antibacterials after surgery after accepting a large amount of antibiotic; Local fixed point slow releasing pharmaceutical; Can not only improve the anti-infective effect, prevent the hemorrhage of patient's postoperative tissue, reduce material itself and brought the probability of antibacterial and more fast effectively into for the antibacterial of killing wound site; Intravenous injection antibiotic more than general is more targeted, and utilization rate is higher.In addition, for the wound of having sewed up, have antibiotic adherence preventing material and can also effectively suppress bacteriological aftergrowth; And can reduce the infringement of antibiotic greatly to patient body; Improve the effect of operation, accelerate the healing rate of wound, be beneficial to patient's post-operative recovery.
Therefore, we demand seeking a kind of proper polymer material urgently at present, utilize electrostatic spinning technique; Preparation anti fibrous membrane designs medicine embedding form simultaneously and discharges route, prepares a kind of reasonable material; Have antiblocking effect, can stop blooding simultaneously, realize suiting the remedy to the case with antibiotic; The efficient treatment reaches the double effects of prevention of postoperative adhesion and postoperative infection.
Summary of the invention:
The present invention is directed to the deficiency of prior art, a kind of anti fibrous membrane with hemostatic and antibacterial function and preparation method thereof is provided.
A kind of anti fibrous membrane with hemostatic and antibacterial function is characterized in that: obtain complex fiber material with carrying out electrostatic spinning after organic polymer solution and the drug molecule mixing.This fibrous membrane can keep the medicine biological activity, and different pharmaceutical is carried out the fibrous material of sustained release by stages, and whole preparation process is simple, and cost is low.
Said organic polymer weight average molecular weight is 5～500,000, is selected from polylactic acid-glycolic guanidine-acetic acid copolymer (PLGA), PEO (PEO), polyvinyl alcohol (PVA), polylactic acid (PLA), polylactic-co-glycolic acid (PELA) and polycaprolactone (PCL).
Described drug molecule is the mix preparation of hemorrhage and antibacterial.
Said hemorrhage is selected from a kind of in carbazochrome sodium sulfonate, tranexamic acid, Desmopressin, the vitamin K1.
Said antibacterial is selected from a kind of in metronidazole, tinidazole, cefalexin, the levofloxacin.
A kind of anti fibrous membrane method for preparing with hemostatic and antibacterial function, step is following:
(1) compounding pharmaceutical molecular solution: be dissolved in inorganic drug molecule or organic solvent, be mixed with the drug solution that concentration is 5-20%W/V, after ultrasonic 10-20 minute, stirring at room 2-5 hour.
(2) preparation macromolecular solution: different macromolecular materials is dissolved in the drug solution of above-mentioned hemorrhage and antibacterial respectively, is mixed with macromolecule and medicament mixed solution that mass percentage concentration is 20-60%.
(3) preparation complex fiber material: with said organic polymer and hemorrhage, and the mixed solution of macromolecule and antibacterial, inject the 5ml syringe respectively; Use No. 5 the rustless steel medicated pillow, diameter 1-5mm is 10～30KV at voltage; Solution flow rate is 1～5ml/h, and receiving range is to carry out electrostatic spinning under the condition of 5～25cm, obtains complex fiber material room temperature vacuum drying 24-48 hour; Remove residual solvent, and in 4 ° of drying baker, preserve.
The pairing inorganic or organic solvent of described hemorrhage is respectively: carbazochrome sodium sulfonate is dissolved in the mixed liquor of dimethyl formamide (DMF) and acetone; Tranexamic acid is dissolved in the phosphate buffer or the acetone of cyclodextrin; Water-soluble or the dimethyl formamide (DMF) of Desmopressin; Vitamin K is dissolved in the mixed liquor of dimethyl sulfoxide (DMSO) or dimethyl sulfoxide (DMSO) and water.
The pairing inorganic or organic solvent of said antibacterial is respectively: metronidazole is dissolved in dimethyl formamide (DMF); The mixed liquor of tinidazole water-soluble or acetone and dimethyl formamide (DMF); Cefalexin is dissolved in the solution of dimethyl formamide (DMF) or chloroform; Levofloxacin is dissolved in phosphate buffer (PBS) or oxolane.
Said phosphate buffer (PBS) is medical domain a kind of solution commonly used, and its PH=7.4 oozes with blood of human body etc., and main component is dibastic sodium phosphate, sodium dihydrogen phosphate, sodium chloride and potassium chloride.
The present invention utilizes electrostatic spinning technique to produce nanofiber, with carrying out electrostatic spinning after organic polymer solution and the drug molecule mixing, obtains complex fiber material; Through the regulation and control macromolecular material, improved the embedding amount and the embedding rate of medicine, can realize the sustained release by stages of hemorrhage and antibacterial simultaneously; Prepare and a kind ofly can keep the medicine biological activity; And different pharmaceutical is carried out the fibrous material of sustained release by stages, can realize the double effects of prevention of postoperative adhesion and postoperative infection, and whole preparation process is simple; Cost is low, and the orthopaedic surgical operations field of surgery has wide practical use.
The specific embodiment:
In order to deepen that understanding of the present invention is made further detailed description below in conjunction with embodiment to the present invention, below describe preferred implementation of the present invention, but be not in order to limit the present invention.
A kind of anti fibrous membrane method for preparing with hemostatic and antibacterial function, step is following:
(1) compounding pharmaceutical molecular solution: hemorrhage carbazochrome sodium sulfonate and antibacterial tinidazole are dissolved in respectively in the mixed solution of acetone and dimethyl formamide (DMF) (other 1: 1 of volume); Be mixed with the drug solution that concentration is 5 and 10% (W/V); After ultrasonic 10 minutes, stirring at room 2 hours.
(2) preparation macromolecular solution: polylactic acid-glycolic guanidine-acetic acid copolymer (PLGA) and polylactic-co-glycolic acid (PELA) (mass ratio 85: 15) are dissolved in above-mentioned hemorrhage solution; Polylactic acid-glycolic guanidine-acetic acid copolymer (PLGA) is dissolved in above-mentioned antimicrobial, is mixed with mass percentage concentration and is 50% macromolecule and medicament mixed solution.
(3) preparation complex fiber material: with said organic polymer and hemorrhage, and the mixed solution of macromolecule and antibacterial, inject the 5ml syringe respectively; Adding No. 5 rustless steel medicated pillows (diameter 3mm), is 20KV at voltage, and solution flow rate is 5ml/h; Receiving range is to carry out electrostatic spinning under the condition of 20cm; Obtain complex fiber material room temperature vacuum drying 24 hours, remove residual solvent, and in 4 ° of drying baker, preserve.
Claims (8)
1. the anti fibrous membrane with hemostatic and antibacterial function is characterized in that: obtain complex fiber material with carrying out electrostatic spinning after organic polymer solution and the drug molecule mixing.
2. a kind of anti fibrous membrane according to claim 1 with hemostatic and antibacterial function; It is characterized in that: the organic polymer weight average molecular weight is 5～500,000, is selected from polylactic acid-glycolic guanidine-acetic acid copolymer, PEO, polyvinyl alcohol, polylactic acid, polylactic-co-glycolic acid and polycaprolactone.
3. a kind of anti fibrous membrane with hemostatic and antibacterial function according to claim 1, it is characterized in that: described drug molecule is the mix preparation of hemorrhage and antibacterial.
4. a kind of anti fibrous membrane with hemostatic and antibacterial function according to claim 3 is characterized in that: said hemorrhage is selected from a kind of in carbazochrome sodium sulfonate, tranexamic acid, Desmopressin, the vitamin K1.
5. a kind of anti fibrous membrane with hemostatic and antibacterial function according to claim 3 is characterized in that: said antibacterial is selected from a kind of in metronidazole, tinidazole, cefalexin, the levofloxacin.
6. anti fibrous membrane method for preparing with hemostatic and antibacterial function, it is characterized in that: step is following:
(1) compounding pharmaceutical molecular solution: be dissolved in inorganic drug molecule or organic solvent, be mixed with the drug solution that concentration is 5-20%W/V, after ultrasonic 10-20 minute, stirring at room 2-5 hour.
(2) preparation macromolecular solution: different macromolecular materials is dissolved in the drug solution of above-mentioned hemorrhage and antibacterial respectively, is mixed with macromolecule and medicament mixed solution that mass percentage concentration is 20-60%.
(3) preparation complex fiber material: with said organic polymer and hemorrhage, and the mixed solution of macromolecule and antibacterial, inject the 5ml syringe respectively; Use No. 5 the rustless steel medicated pillow, diameter 1-5mm is 10～30KV at voltage; Solution flow rate is 1～5ml/h, and receiving range is to carry out electrostatic spinning under the condition of 5～25cm, obtains complex fiber material room temperature vacuum drying 24-48 hour; Remove residual solvent, and in 4 ° of drying baker, preserve.
7. a kind of anti fibrous membrane method for preparing with hemostatic and antibacterial function according to claim 6 is characterized in that: the pairing inorganic or organic solvent of hemorrhage is respectively: carbazochrome sodium sulfonate is dissolved in the mixed liquor of dimethyl formamide (DMF) and acetone; Tranexamic acid is dissolved in the phosphate buffer or the acetone of cyclodextrin; Water-soluble or the dimethyl formamide (DMF) of Desmopressin; Vitamin K is dissolved in the mixed liquor of dimethyl sulfoxide (DMSO) or dimethyl sulfoxide (DMSO) and water.
8. a kind of anti fibrous membrane method for preparing with hemostatic and antibacterial function according to claim 6 is characterized in that: the pairing inorganic or organic solvent of antibacterial is respectively: metronidazole is dissolved in dimethyl formamide (DMF); The mixed liquor of tinidazole water-soluble or acetone and dimethyl formamide (DMF); Cefalexin is dissolved in the solution of dimethyl formamide (DMF) or chloroform; Levofloxacin is dissolved in phosphate buffer (PBS) or oxolane.
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Cited By (16)
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|---|---|---|---|---|
| CN102641520A (en) * | 2012-05-07 | 2012-08-22 | 吉林大学 | Preparation method of biological repair nano dressing containing wood frog skin polypeptide and being used for wounds and burn |
| CN102671234A (en) * | 2012-05-22 | 2012-09-19 | 中国人民解放军第四五四医院 | Nanometer hemostatic material product and preparation method thereof |
| CN102908649A (en) * | 2012-11-09 | 2013-02-06 | 无锡中科光远生物材料有限公司 | Anti-adhesion fibrous membrane with hematostatic function |
| CN102908671A (en) * | 2012-11-09 | 2013-02-06 | 无锡中科光远生物材料有限公司 | Preparation method for anti-bacterial and anti-adhesion urinary catheter |
| CN102908670A (en) * | 2012-11-09 | 2013-02-06 | 无锡中科光远生物材料有限公司 | Antiseptic anti-adhesion catheter |
| CN102908658A (en) * | 2012-11-09 | 2013-02-06 | 无锡中科光远生物材料有限公司 | Electrostatic spinning polymer anti-adhesion fibrous membrane with excellent flexibility |
| CN102920530A (en) * | 2012-11-09 | 2013-02-13 | 无锡中科光远生物材料有限公司 | Anti-adhesion absorbable hernia patch |
| CN102949706A (en) * | 2012-11-01 | 2013-03-06 | 海南建邦制药科技有限公司 | In-situ hemostatic containing desmopressin |
| CN103768662A (en) * | 2014-02-26 | 2014-05-07 | 中国科学院长春应用化学研究所 | Preparation method of biodegradable medical surgical anti-adhesion membrane |
| CN104873535A (en) * | 2015-05-15 | 2015-09-02 | 厦门迅朗生物技术有限公司 | Anti-adhering liquid of polylactic acid-hydroxyacetic acid copolymer and preparation method thereof |
| WO2016095824A1 (en) * | 2014-12-18 | 2016-06-23 | 上海微创医疗器械（集团）有限公司 | Anti-infective dressing bag and fabricating method therefor |
| CN105709280A (en) * | 2014-12-18 | 2016-06-29 | 上海微创医疗器械（集团）有限公司 | Anti-infection covering bag and preparation method thereof |
| CN107059157A (en) * | 2017-04-26 | 2017-08-18 | 苏州大学 | Porous nuclear shell structure nano fiber and preparation method thereof |
| CN108392671A (en) * | 2018-05-21 | 2018-08-14 | 哈尔滨理工大学 | A kind of preparation method of degradable bletilla polysaccharide hemostasis composite membrane |
| CN108904858A (en) * | 2018-07-27 | 2018-11-30 | 西北师范大学 | A kind of polyvinyl alcohol/trifluoroacetic acid lappaconitine composite cellulosic membrane and its preparation and application |
| WO2020186715A1 (en) * | 2019-03-15 | 2020-09-24 | 深圳市光远生物材料有限责任公司 | Drug-loaded nanofiber film and preparation method and application thereof |
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Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102641520A (en) * | 2012-05-07 | 2012-08-22 | 吉林大学 | Preparation method of biological repair nano dressing containing wood frog skin polypeptide and being used for wounds and burn |
| CN102671234A (en) * | 2012-05-22 | 2012-09-19 | 中国人民解放军第四五四医院 | Nanometer hemostatic material product and preparation method thereof |
| CN102949706A (en) * | 2012-11-01 | 2013-03-06 | 海南建邦制药科技有限公司 | In-situ hemostatic containing desmopressin |
| CN102908658B (en) * | 2012-11-09 | 2016-08-10 | 无锡中科光远生物材料有限公司 | The electrospun polymer anti-adhesion fiber membrane that compliance is good |
| CN102908649A (en) * | 2012-11-09 | 2013-02-06 | 无锡中科光远生物材料有限公司 | Anti-adhesion fibrous membrane with hematostatic function |
| CN102908671A (en) * | 2012-11-09 | 2013-02-06 | 无锡中科光远生物材料有限公司 | Preparation method for anti-bacterial and anti-adhesion urinary catheter |
| CN102908670A (en) * | 2012-11-09 | 2013-02-06 | 无锡中科光远生物材料有限公司 | Antiseptic anti-adhesion catheter |
| CN102908658A (en) * | 2012-11-09 | 2013-02-06 | 无锡中科光远生物材料有限公司 | Electrostatic spinning polymer anti-adhesion fibrous membrane with excellent flexibility |
| CN102920530A (en) * | 2012-11-09 | 2013-02-13 | 无锡中科光远生物材料有限公司 | Anti-adhesion absorbable hernia patch |
| CN103768662A (en) * | 2014-02-26 | 2014-05-07 | 中国科学院长春应用化学研究所 | Preparation method of biodegradable medical surgical anti-adhesion membrane |
| CN103768662B (en) * | 2014-02-26 | 2016-06-01 | 中国科学院长春应用化学研究所 | The preparation method of a kind of biodegradable medical surgery anti-adhesion membrane |
| WO2016095824A1 (en) * | 2014-12-18 | 2016-06-23 | 上海微创医疗器械（集团）有限公司 | Anti-infective dressing bag and fabricating method therefor |
| CN105709280A (en) * | 2014-12-18 | 2016-06-29 | 上海微创医疗器械（集团）有限公司 | Anti-infection covering bag and preparation method thereof |
| CN104873535A (en) * | 2015-05-15 | 2015-09-02 | 厦门迅朗生物技术有限公司 | Anti-adhering liquid of polylactic acid-hydroxyacetic acid copolymer and preparation method thereof |
| CN107059157A (en) * | 2017-04-26 | 2017-08-18 | 苏州大学 | Porous nuclear shell structure nano fiber and preparation method thereof |
| CN108392671A (en) * | 2018-05-21 | 2018-08-14 | 哈尔滨理工大学 | A kind of preparation method of degradable bletilla polysaccharide hemostasis composite membrane |
| CN108904858A (en) * | 2018-07-27 | 2018-11-30 | 西北师范大学 | A kind of polyvinyl alcohol/trifluoroacetic acid lappaconitine composite cellulosic membrane and its preparation and application |
| WO2020186715A1 (en) * | 2019-03-15 | 2020-09-24 | 深圳市光远生物材料有限责任公司 | Drug-loaded nanofiber film and preparation method and application thereof |
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Application publication date: 20120404 |