CN102304439B - Antibacterial cleaning solution for full-automatic biochemistry analyzer - Google Patents
Antibacterial cleaning solution for full-automatic biochemistry analyzer Download PDFInfo
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- CN102304439B CN102304439B CN 201110225798 CN201110225798A CN102304439B CN 102304439 B CN102304439 B CN 102304439B CN 201110225798 CN201110225798 CN 201110225798 CN 201110225798 A CN201110225798 A CN 201110225798A CN 102304439 B CN102304439 B CN 102304439B
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Abstract
The present invention discloses an antibacterial cleaning solution for a full-automatic biochemistry analyzer. The antibacterial cleaning solution is characterized in that: each 1 L of the antibacterial cleaning solution comprises: 0.5-1.0 g of an alkali metal hydroxide, 0.9-1.8 g of an inorganic salt, a non-ionic surfactant, a quaternary ammonium salt cationic surfactant and a foam inhibitor, wherein the volume percentage of the non-ionic surfactant is 0.1-1.0%, the volume percentage of the quaternary ammonium salt cationic surfactant is 0.005-0.02%, and the volume percentage of the foam inhibitor is 0.2-2.0%. The antibacterial cleaning solution provided by the present invention has characteristics of cheap price and low cost, can effectively remove the fibrin, crystal, grease, dyes, latex particles, and other residues easily adhered to the cuvette so as to effectively clean the cuvette, and ensure the accuracy of the test result.
Description
Technical field
The present invention relates to a kind of antibacterial cleaning solution for automatic clinical chemistry analyzer, specifically, provide the antibacterial cleaning solution that automatic clinical chemistry analyzer uses when analytical specimen and routine maintenance, be used for keeping the cleaning of cuvette, reduce difference between cup, reduce crossed contamination between sample, guarantee the good of instrument running status.
Background technology
Automatic clinical chemistry analyzer is being born a large amount of work take its high accuracy, high degree of accuracy, high flexibility and high efficiency as characteristics in clinical labororatory, is one of instrument of being most widely used of present clinical labororatory.In clinical labororatory, need on the one hand the project of detection many, the corresponding external diagnosis reagent complicated that uses, specimen types is various on the other hand, serum, blood plasma, urine, ascites pleural fluid, cerebrospinal fluid etc. are arranged, therefore, cuvette, pipeline etc. just might be by pollutions such as scleroproein, crystallization, grease, dyestuffs, breed bacteria, can't guarantee the plot of instrument, this shows that cleaning performance can directly affect the accuracy of detected result, in order to obtain reliable detected result, it is particularly important that the cleaning system of full automatic biochemical apparatus shows.
The automatic biochemistry analyzer of domestic use, its reaction cup great majority belong to the discrete water bath with thermostatic control, and the hatching tank and generally need to use the scavenging solution routine cleaning of this kind automatic biochemistry analyzer is to keep its cleaning, prevent bacterial growth, and reaction cup need to be soaked regularly with scavenging solution.
Antibacterial cleaning solution wherein is mainly used in the reinforcement cleaning of cuvette and the cleaning of reaction incubation slot.
The antibacterial cleaning solution source of at present clinical labororatory's use mainly is dependence on import, but the import reagent cost is higher, so that the testing cost increase, so its widespread use is restricted; Also having on the one hand is domestic antibacterial cleaning solution, but practical effect is not good enough, particularly for the test item of latex enhancing immune than turbid transmission method (PETIA Latex-enhanced immunoturbidimetric assay), because the latex that contains in the reagent is a kind of high molecular polymer, its major ingredient is polystyrene, it is easy to adhere on the cuvette, polypropylene material cuvette particularly, the situation severe patient, internal surface at cuvette forms one deck oyster white bur, these oyster white burs can affect the light transmission of cuvette, and then affect absorbance reading, finally cause detected result inaccurate.
Summary of the invention
The present invention is directed to the above-mentioned deficiency of prior art, provide a kind of low price, cost low, and can effectively remove scleroproein, crystallization, grease, dyestuff, latex particle etc. and be easy to adhere to residue on the cuvette, thereby effectively clean cuvette, guarantee the antibacterial cleaning solution that is used for automatic clinical chemistry analyzer of detected result accuracy.
In order to solve the problems of the technologies described above, the technical solution used in the present invention is: a kind of for the automatic clinical chemistry analyzer antibacterial cleaning solution, contain in every 1L antibacterial cleaning solution: contain in every 1L antibacterial cleaning solution (water is settled to 1L): the alkali metal hydroxide of 0.5 ~ 1.0g, 0.9 the inorganic salt of ~ 1.8g, volume is very than the nonionogenic tenside that is 0.1 ~ 1.0%, volume is very than the quaternary cationics that is 0.005 ~ 0.02%, and volume is very than the suds suppressor that is 0.2 ~ 2.0%.
As preferably, above-mentioned content for each composition of automatic biochemical analysis antibacterial cleaning solution is: contain in every 1L antibacterial cleaning solution: the alkali metal hydroxide of 0.75g, 1.35g inorganic salt, volume is very than the nonionogenic tenside that is 0.5%, volume is very than the quaternary cationics that is 0.0125%, and volume is very than the suds suppressor that is 1%.
Alkali metal hydroxide of the present invention is sodium hydroxide or potassium hydroxide; Described inorganic salt are water glass or yellow soda ash; Described nonionogenic tenside is that polyoxyethylene glycol is to iso-octyl phenyl ether (Triton X – 100 or title Triton X-100) or polyoxyethylene sorbitan monooleate (Tween-80); Described quaternary cationics is that bromine alkyl dimethyl is for benzene methanamine (bromogeramine or dodecyl dimethyl benzyl ammonium bromide) or dodecyl dimethyl phenoxy group brometo de amonio (domiphen bromide or dodecyl-dimethyl-2-phenoxy group-ethyl brometo de amonio) or tetradecyl lutidine brometo de amonio (Myristylpicolinii Bromide); Described suds suppressor is Virahol.
By above technical scheme as seen, except containing alkali metal hydroxide, also contain inorganic salt, nonionogenic tenside, quaternary cationics and suds suppressor in the automatic biochemistry analyzer antibacterial cleaning solution provided by the invention.
Wherein, inorganic salt play the effect of a washing assistant in antibacterial cleaning solution, and cost is low, and in the inorganic salt washing assistant, alkaline, inorganic salts is better to the effect that strengthens the tensio-active agent decontamination.
Nonionogenic tenside has very strong surface-active action, plays in the present invention the effect of a cleaning, emulsification.
Quaternary cationics has the character of acid-fast alkali-proof, de-sludging, has simultaneously germicidal action, and it has very strong adsorption at bacterium surface, thereby stops breathing and the sugared solution effect of bacterium, impels protein denaturation, plays the effect of sterilization.
Suds suppressor preferably adopts Virahol, can effectively eliminate the bubble that produces when reaction cup is rotated.
Advantage of the present invention and beneficial effect:
1. scavenging solution of the present invention is used for the cleaning of automatic biochemistry analyzer, cleaning performance is good, cost is low, and (raw material is commercial product, be easy to get, cheaply), good stability, low residue, detected result is accurate and precision good, and the high molecular polymer that especially can solve in the PETIA method of testing adheres to the problem that cuvette forms the oyster white bur.
2. not only cost is low for scavenging solution of the present invention, good stability, and have the advantages such as low residue and low crossed contamination.
Embodiment
Further set forth the present invention below in conjunction with specific embodiment, but be not limited to following embodiment.
Embodiment 1
Weigh in the balance and get sodium hydroxide 1.0g, water glass 1.8g, then with the water of 500-700mL with sodium hydroxide and water glass dissolving (be sodium hydroxide and water glass the two altogether dissolve with the water of 500-700mL), again toward wherein slowly adding Triton X-100 (Triton X-100) 10mL, Virahol 20mL, commercially available 1% bromogeramine (dodecyl dimethyl benzyl ammonium bromide) 20mL, stirring treats that it fully dissolves, add water at last the 1L mixing, namely obtain the stable automatic biochemistry analyzer antibacterial cleaning solution of 1L.
Embodiment 2
Weigh in the balance and get sodium hydroxide 0.5g, water glass 0.9g, use the 500-700mL water dissolution, again toward wherein slowly adding Triton X-100 1mL, Virahol 2mL, commercially available 1% bromogeramine 5mL stirs and treats that it fully dissolves, add water at last the 1L mixing, namely obtain the stable automatic biochemistry analyzer antibacterial cleaning solution of 1L.
Embodiment 3
Weigh in the balance and get sodium hydroxide 0.75g, water glass 1.35g, use the 500-700mL water dissolution, again toward wherein slowly adding Triton X-100 5mL, Virahol 10mL, commercially available 1% bromogeramine 12.5mL stirs and treats that it fully dissolves, add water at last the 1L mixing, namely obtain the stable automatic biochemistry analyzer antibacterial cleaning solution of 1L.
Embodiment 4
Weigh in the balance and get potassium hydroxide 0.5g, yellow soda ash 0.9g, use the 500-700mL water dissolution, again toward wherein slowly adding Tween-80 1mL, Virahol 2mL, commercially available Myristylpicolinii Bromide powder 0.05g stirs and treats that it fully dissolves, add water at last the 1L mixing, namely obtain the stable automatic biochemistry analyzer antibacterial cleaning solution of 1L.
Embodiment 5
Test above-mentioned antibacterial cleaning solution on-line cleaning performance with Hitachi's 7060 automatic biochemistry analyzers, behind the execution wash procedure, get Luo Shi low value Quality Control B
1With high value Quality Control B
2The projects such as replication triglyceride level (TG), lipase (LPS), total protein (TP), picric acid method creatinine (CREA), gpt (ALT), β-hydroxybutyric acid (BHB) are each 20 times on Hitachi's 7060 automatic biochemistry analyzers, again in 20 days to repeatability between doing with a collection of Quality Control batch, test item is identical, its repeatability is good, in batch and betweenrun precision be respectively the CV(variation coefficient)≤1.80% and CV≤3.82%.
After using scavenging solution of the present invention to clean instrument, the detected result precision of instrument is good, without crossed contamination; Before and after the test, lower glass of blank of 340nm wavelength has low residue without significant difference, and the high molecular polymer that especially solves in the PETIA reagent adheres to the problem that cuvette forms the oyster white bur.
Embodiment 6
The antibacterial cleaning solution of preparation is divided into two equal portions, preserved 6 months with 25 ℃ respectively at 4 ℃, outward appearance, pH value have no significant change.Compare experiment with placing the antibacterial cleaning solution of 6 months antibacterial cleaning solution of room temperature with new preparation, test above-mentioned antibacterial cleaning solution on-line cleaning performance with Hitachi's 7060 automatic biochemistry analyzers, behind the execution wash procedure, get Luo Shi low value Quality Control B
1With high value Quality Control B
2Replication TG, LPS, TP, CREA, the projects such as ALT, β-BHB are each 20 times on Hitachi's 7060 automatic biochemistry analyzers, the result show two groups of results without significant difference (
p﹥ 0.05), dependency good (
r﹥ 0.995).Therefore, antibacterial cleaning solution good stability of the present invention is placed and its result of use to be had no significant effect in 6 months to being less than room temperature.
Claims (2)
1. antibacterial cleaning solution that is used for automatic clinical chemistry analyzer, it is characterized in that: contain in every 1L antibacterial cleaning solution: the alkali metal hydroxide of 0.5～1.0g, 0.9 the inorganic salt of～1.8g, volume percent is 0.1～1.0% nonionogenic tenside, volume percent is 0.005～0.02% quaternary cationics, and volume percent is 0.2～2.0% suds suppressor;
Described alkali metal hydroxide is sodium hydroxide or potassium hydroxide;
Described inorganic salt are water glass or yellow soda ash;
Described nonionogenic tenside is that polyoxyethylene glycol is to iso-octyl phenyl ether or polyoxyethylene sorbitan monooleate;
Described quaternary cationics is dodecyl dimethyl benzyl ammonium bromide or dodecyl dimethyl phenoxy group brometo de amonio or tetradecyl lutidine brometo de amonio;
Described suds suppressor is Virahol.
2. the antibacterial cleaning solution for automatic clinical chemistry analyzer according to claim 1, it is characterized in that: contain in every 1L antibacterial cleaning solution: the alkali metal hydroxide of 0.75g, 1.35g inorganic salt, volume percent is 0.5% nonionogenic tenside, volume percent is 0.0125% quaternary cationics, and volume percent is 1% suds suppressor.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107034054A (en) * | 2017-04-01 | 2017-08-11 | 合肥迪安医学检验所有限公司 | A kind of biochemical instruments cuvette cleaning fluid |
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| CN103897909A (en) * | 2012-12-28 | 2014-07-02 | 上海复星医药（集团）股份有限公司 | Cleaning solution applied to automatic biochemical analyzer |
| CN103412088B (en) * | 2013-07-26 | 2015-05-27 | 北京控制工程研究所 | Chemical test method for bipropellant thruster after thermal standard cleaning |
| CN104017667A (en) * | 2014-06-25 | 2014-09-03 | 南通永康检测技术有限公司 | Antibacterial cleaning solution for instruments |
| CN106753876A (en) * | 2015-11-23 | 2017-05-31 | 迈瑞南京生物技术有限公司 | Bottle-washing agent |
| CN105754733A (en) * | 2016-02-04 | 2016-07-13 | 广州科方生物技术有限公司 | Cleaning solution for chemiluminescence immunity analyzer |
| CN106726705A (en) * | 2017-01-04 | 2017-05-31 | 长江医学科学院 | A kind of skin cleansing liquid and preparation method thereof |
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| CN107557180A (en) * | 2017-09-26 | 2018-01-09 | 重庆赞龙生物科技有限公司 | A kind of cleaning fluid |
| CN107881021A (en) * | 2017-11-23 | 2018-04-06 | 中山市创艺生化工程有限公司 | A kind of thermostat cleaning fluid and preparation method thereof |
| CN108004038B (en) * | 2017-11-23 | 2020-12-25 | 中山市创艺生化工程有限公司 | Alkaline cleaning fluid and preparation method thereof |
| CN109022169A (en) * | 2018-05-21 | 2018-12-18 | 苏州佑君环境科技有限公司 | A kind of chemiluminescence instrument pipeline composite cleaning liquid and preparation method thereof |
| CN115368975A (en) * | 2022-08-03 | 2022-11-22 | 吉林基蛋生物科技有限公司 | Alkaline cleaning fluid and preparation method thereof |
| CN116286205B (en) * | 2022-12-23 | 2024-04-19 | 浙江鑫科医疗科技有限公司 | Tripropylamine buffer solution matched with Luo Cobas e801 chemiluminescent immunoassay analyzer and preparation method thereof |
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| CN1566304A (en) * | 2003-06-13 | 2005-01-19 | 李小平 | Full automatic biochemical analyzer cleaning agent |
| CN102102051A (en) * | 2010-12-01 | 2011-06-22 | 宁波美康盛德生物科技有限公司 | Alkaline cleaning solution applied to automatic biochemical analyzer |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1566304A (en) * | 2003-06-13 | 2005-01-19 | 李小平 | Full automatic biochemical analyzer cleaning agent |
| CN102102051A (en) * | 2010-12-01 | 2011-06-22 | 宁波美康盛德生物科技有限公司 | Alkaline cleaning solution applied to automatic biochemical analyzer |
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| CN107034054A (en) * | 2017-04-01 | 2017-08-11 | 合肥迪安医学检验所有限公司 | A kind of biochemical instruments cuvette cleaning fluid |
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Owner name: NINGBO MEDICALSYSTEM CLINICAL LABORATORIES CO., LT Free format text: FORMER OWNER: NINGBO MEDICALSYSTEM BIOTECHNOLOGY CO., LTD. Effective date: 20121119 |
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Effective date of registration: 20121119 Address after: 315104 No. 269, Qiming Road, Ningbo, Zhejiang, Yinzhou District 315104 Applicant after: Ningbo Medicalsystem Clinical Laboratories Co., Ltd. Address before: 315104 Zhejiang city of Ningbo province Yinzhou District Qiming Road No. 289 Applicant before: Ningbo Meikang Shengde Biotechnology Co., Ltd. |
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