CN102302033A - Preparation and application of compounded disinfection atomization agent - Google Patents
Preparation and application of compounded disinfection atomization agent Download PDFInfo
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- CN102302033A CN102302033A CN201110193460A CN201110193460A CN102302033A CN 102302033 A CN102302033 A CN 102302033A CN 201110193460 A CN201110193460 A CN 201110193460A CN 201110193460 A CN201110193460 A CN 201110193460A CN 102302033 A CN102302033 A CN 102302033A
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Abstract
The invention provides a compounded disinfection atomization agent. The compounded disinfection atomization agent comprises the following ingredients in percentage by mass: 0.01-5% of guanidine compound, 0.01-10% of quaternary ammonium compounds, 0.01-2% of ethylenebisiminoacetic acid B, 0.01-2% of 2-bromo-2-nitro-1,3-propylene glycol, 0.01-10% of monohydric alcohol, 0-30% of dihydric alcohol, 0-30% of polyatomic alcohol and the balance of water. According to the invention, the purpose includes the preparation of the compounded disinfection atomization agent, wherein the preparation comprises the following steps of: mixing the guanidine compound, the quaternary ammonium compounds, the 2-bromo-2-nitro-1,3-propylene glycol and the ethylenebisiminoacetic acid B according to the mass percentage together with 50% of water by mass for 3 hours so as to obtain a mixture A; mixing the monohydric alcohol, the dihydric alcohol and the polyatomic alcohol according to the mass percentage together with the rest 50% of water by mass for 3 hours so as to obtain a mixture B; and stirring the mixture A and the mixture B and reacting the mixture for 2 hours; standing the reaction product for 2 hours; detecting the content of the mixed mixture; and packaging the standard mixture to obtain a standard product.
Description
Technical field
The invention belongs to the disinfection product scope; Relate to a kind of composite disinfecting Alevaire; Especially a kind of guanidine compound, quaternary ammonium compound, 2-bromo-2-nitro-1 of containing, the composition thing of ammediol, the upright imperial B of holder, monohydric alcohol, dihydroxylic alcohols and polyalcohol is as the preparation and the application of disinfectant.
Background technology
For a long time, extensively adopt chlorine-containing disinfectant, brominated disinfectant, guanidine class disinfectant and quaternary ammonium disinfectant in the sterile products field always.
The disinfection principle of chlorine-containing disinfectant is based on its hypochlorous sterilizing mechanisms through generating behind the hydrolysis in water.But in long-term use, find following shortcoming:
1, the pH value narrow range of its effective killing microorganisms, its minimum dissociation reaction occurs in the pH7.0 place, and when the pH value continued to raise, hypochlorous acid was dissociated into the hypochlorite ion of the power extreme difference of killing livestock easily in a large number.Because hypochlorite ion has negative electrical charge, when its when the microorganism, receive the anion exclusion of load on the microorganism wall, be difficult to permeate through cell membranes, therefore just lost the vigor of killing microorganisms;
2, it can generate the carcinogenic substance chloroform with the organic matter in the water;
3, it has the smelly pungent taste of unpleasant chlorine, and skin is had excitant;
4, it is corrosive to metal, and fabric is had damage etc.
The disinfection principle of bromine-containing disinfectant is based on its sterilizing mechanisms through the hypobromous acid that generates behind the hydrolysis in water.But in use, find following shortcoming:
1, its solvability in water is little, and dissolution velocity is slow, has influenced it greatly as the application of disinfectant in the sterilization field;
2, its unpleasant bromine pungent taste has excitant to skin;
3, its metal is corrosive etc.
Summary of the invention
The objective of the invention is to provides a kind of preparation and application of composite disinfecting Alevaire to the various drawbacks of existing sterilization Alevaire with for solving the technical problem that exists in the known technology; Especially contain guanidine compound, quaternary ammonium compound, 2-bromo-2-nitro-1; Ammediol, the upright imperial B of holder, monohydric alcohol, dihydroxylic alcohols and polyalcohol be as the preparation and the application of sterilization Alevaire, and it has characteristics such as safety, efficient, wide spectrum, low toxicity, environmental protection.
One of the object of the invention provides a kind of composite disinfecting Alevaire, especially a kind of preparation of the sterilization Alevaire with multiple effective disinfectant component combination, and it contains following component by mass percent:
| Component | Mass percent % |
| Guanidine compound | 0.01~5 |
| Quaternary ammonium compound | 0.01~10 |
| Tuo Lilong B | 0.01~2 |
| 2-bromo-2-nitro-1, ammediol | 0.01~2 |
| Monohydric alcohol | 0.01~10 |
| Dihydroxylic alcohols | 0~30 |
| Polyalcohol | 0~30 |
| Water | Surplus |
Guanidine compound described in the component is selected from: the mixture of one or more in polyhexamethylene guanide, the poly hexamethylene biguanide etc., or one or more mixture of above-mentioned guanidine compound pharmaceutically acceptable salt.
Wherein the hydrochloride in the polyhexamethylene guanide is a kind of white amorphous powder, and no special odor is soluble in water, and the aqueous solution is colourless to faint yellow, tasteless, does not fire not quick-friedly, and metal material is not had corrosion basically, and decomposition temperature is greater than 400 ℃, and molecular formula is (C
7H
16N
3Cl)
n, to the handle no discoloration in surface, undergoing no deterioration in 2 years, the aqueous solution of 0.1 % concentration has the taste of little hardship.Very extensive in the every field application, can be used as the candida albicans disinfectant of various body surfaces, and can make daily mould inhibitor; Can be widely used in beverage and food-processing industry; Drinking water and swimming pool; Lake water, pool, cooling tower, fountain, remove algae, oil exploitation, construction material mildewproof additive; Plant's sterilization; And be used for textile industry, paper-making industry, wood-processing industry, rubber industry, agricultural etc., also can be used as the flocculant of waste water treatment.
Hexamethylene wherein; Its colorless and odorless, water-soluble fully, stable in properties; Its bactericidal mechanism is different with chlorine-containing disinfectant; Strong oxidation reaction does not take place in the sterilization process; Produce precipitation in the cell; The quantity of endocellular phosphorus rises simultaneously, thereby block cell wall and nucleic acid is synthetic; Reduce the cell permeability of the membrane, stop phosphorus to cell exocrine, and the ability bind protein, this disinfectant is widely used in pharmaceuticals industry, has when reporting it as mouthwash, and is very strong to the Gram-negative bacteria property killed.
Quaternary ammonium compound described in the component is selected from: the mixture of one or more in n-zephiran, n-alkyl dimethyl ethylbenzylammonium chloride, two n-zephiran, benzalkonium bromide and the benzalkonium chloride etc.
Wherein the n in the n-zephiran is 8-18, like dodecyl benzyl dimethyl ammonium chloride, hexadecyldimethyl benzyl ammonium benzyl oronain etc.Dodecyl benzyl dimethyl ammonium chloride is white waxy solid or yellow colloid, and the aqueous solution shows neutrality or faintly alkaline reaction, and soluble in water and ethanol has effect clean only, sterilization.When medical operating, be widely used in the sterilization of skin and operating theater instruments, also be widely used in the breed place of economic crops such as Treatment of Industrial Water, fowl corral house, granary, silkworm room and mushroom, tremella and sterilization, the sterilization, anticorrosion of utensil.To human non-toxic, little to skin and eyes mucosa irritation property.
N in wherein two n-zephirans is 8-14.Two n-zephirans are two long chain quaternaries, and product type has multiple combining forms such as two octyl groups, two certain herbaceous plants with big flowers base, two dodecyls, octyl group certain herbaceous plants with big flowers base, and its bactericidal effect obviously strengthens.
Wherein the n in the n-alkyl dimethyl ethylbenzylammonium chloride is 12 ~ 18, molecular formula: N-C
23H
42Cl; Molecular weight: 368.0393; Can be used as hospital; The nursing home, the disinfectant in public place and the industry, and the Biocidal algae-killing agent in swimming pool and the Treatment of Industrial Water; Wood preservation; And the sterilization of medicine equipment, can be used as deodorant simultaneously, product is: alkyl (50%C12; 30%C14; 17%C16,3%C18) dimethyl ethyl benzyl ammonium chloride, alkyl (60%C14; 30%C16; 5%C12,5%C18) dimethyl ethyl benzyl ammonium chloride, as: dodecyl dimethyl ethylbenzylammonium chloride, myristyl dimethyl ethyl benzyl ammonium chloride etc.
Wherein benzalkonium bromide is white waxy solid or yellow colloid; The aqueous solution shows neutrality or faintly alkaline reaction; Soluble in water; Be slightly soluble in ethanol; Be one of surfactant of using always, have cleaning, sterilizing and algae removal effect, be widely used in aspects such as sterilization, sterilization, anticorrosion, emulsification, de-sludging, solubilising; Be industrial cycle water treatment non-oxidizable Biocidal algae-killing agent commonly used, glutinous mud remover and cleaning agent, also can be used for the control of microorganisms and the cleaning of circulation.
Wherein benzalkonium chloride is claimed the dimethyl benzyl alkyl ammomium chloride again, molecular formula: C
17H
30ClN; Belong to cationic surfactant; Belong to non-oxidizable bactericide; Have wide spectrum, sterilization algae removal ability efficiently; Can control bacterium algae propagation and foundry loam growth in the water effectively; And have the effect of peeling off of good foundry loam and certain dispersion, osmosis, have simultaneously certain deoil, deodorizing capability and corrosion inhibition.
2-bromo-2-nitro-1 described in the component; Ammediol; It is white or canescence crystalline powder; Fusing point is greater than 120 ℃; Soluble in water, have the high-efficiency broad spectrum antibacterial activity, be widely used as cosmetics preservative; Also as agriculture chemicals fungicide, medical disinfectant, with the composite industrial water conditioning agent etc. that also can be used as of other preservatives.
The upright imperial B of holder described in the component is white crystalline powder, and is water-soluble, is insoluble in alcohol, as complexing agent, chelating agent, preservative, anti-oxidant synergist and auxiliary agent.
Monohydric alcohol described in the component is 95% ethanol.
Dihydroxylic alcohols described in the component is selected from: the ethylene glycol APEO; 1, the 2-dihydroxypropane; The mixture of one or more in 2-ethyl-2-(methylol)-1,3 propane diols etc.
Wherein the ethylene glycol APEO is an ethylene glycol APEO 200,400,600.It has passed through the U.S. FDA authentication, meets American Pharmacopeia (USP), NF (NF), and Food Chemistry code (FCC) standard is widely used in the production of industries such as food, pharmacy, feed, personal care articles, chemistry.It is the water white transparency thick liquid, and it is sweet to distinguish the flavor of, and has hygroscopicity, and is miscible with water, lower aliphatic alcohols, glycerine, acetic acid, acetone, can be used as solvent, dispersant, lubricant, emulsifier etc. and is used for cosmetics, agricultural chemicals, food, medicine and other fields.
Wherein 1; The 2-dihydroxypropane is the stable water imbibition liquid of colourless thickness; Almost tasteless odorless; With water, ethanol and multiple immiscible organic solvent; As gas-chromatography fixer, solvent, antifreeze, plasticizer, dehydrating agent, carrier solvent, wetting agent, humectant, anticaking agent, antioxidant, surface-active, stabilizing agent, thickener, emulsifier, processing aid; It classifies food processing aid as among the GB 2760-96; Its aqueous solution is effective antifreeze; Can be used as humectant in the cosmetics; Softening agent, solvent etc.
Trihydroxylic alcohol described in the component is selected from: the mixture of one or more in trihydroxy propane, triethylene-glycol, the tetraethylene-glycol etc.
Wherein trihydroxy propane outward appearance is the water white transparency thick liquid; Odorless, tasteless, have hygroscopicity, humectation property, a property of softening; It is neutral that the aqueous solution is; Can mix arbitrarily with water, ethanol, methyl alcohol; Have good freeze-proof, be widely used in industries such as weaving, printing and dyeing, papermaking, printing, washing agent, daily use chemicals, system wine, food, cigarette, glassine paper, enamel, oil, electronics, rubber, plastics, process hides, chemistry, chemical fibre.Main as humectant, humectant, hygroscopic agent, lubricant, softening agent, softening agent, thickener, plasticizer, thinner, antifreezing agent etc.
Wherein the triethylene-glycol outward appearance is that no color or smell has the hygroscopicity thick liquid, can be miscible with water, ethanol, benzene, toluene, be insoluble in ethers, and be insoluble to benzinum, have hygroscopicity, have the character of pure and mild ether.As solvent, extractant, desiccant, air disinfection agent etc.The toxicity data are little poison, LD
50(rat oral) 16.8ml/kg. is to eyes and skin nonirritant.
Water described in the component is deionized water.
Each component is role in the present invention:
Guanidine compound described in the component belongs to cationic surfactant, is low effect disinfectants, has quick-acting bactericidal actions, to mucocutaneous nonirritant, to metal and fabric non-corrosiveness, is subjected to organic substance influence slight, good stability;
Quaternary ammonium compound described in the component belongs to cationic surfactant, is low effect disinfectants, and to mucocutaneous non-stimulated, toxicity is little, and good stability is harmless to article;
2-bromo-2-nitro-1 described in the component, ammediol is a disinfectant, broad spectrum antibiotic activity can effectively suppress Gram-negative bacteria, positive bacteria, saccharomycete and mould;
The upright imperial B of holder described in the component has chelating, complexing and synergistic effect, can remove the Ca that exists in the water
2+, Mg
2+, Fe
2+, Mn
2+Deng metal ion, reach purification;
Monohydric alcohol described in the component has synergistic effect, has hydrotropy and antifreeze effect simultaneously;
Dihydroxylic alcohols described in the component plays good dispersion and antifreeze effect, to mucocutaneous non-stimulated, good stability is harmless to article;
Polyalcohol described in the component plays good atomizing and synergistic effect, to mucocutaneous nonirritant, to metal and fabric non-corrosiveness, good stability.
Composite disinfecting Alevaire of the present invention is the proportioning of following mass percent most preferably:
| Component | Mass percent % |
| Guanidine compound | 0.01~2 |
| Quaternary ammonium compound | 0.01~1 |
| Tuo Lilong B | 0.01~2 |
| 2-bromo-2-nitro-1, ammediol | 0.01~1 |
| Monohydric alcohol | 0.01~5 |
| Dihydroxylic alcohols | 0~20 |
| Polyalcohol | 5~30 |
| Water | Surplus |
Guanidine compound described in the component is selected from: the mixture of one or more in polyhexamethylene guanide, the poly hexamethylene biguanide etc., or one or more mixture of above-mentioned guanidine compound pharmaceutically acceptable salt.
Quaternary ammonium compound described in the component is selected from: the mixture of one or more in n-zephiran, n-alkyl dimethyl ethylbenzylammonium chloride, two n-zephiran, benzalkonium bromide and the benzalkonium chloride etc.; Wherein the n in the n-zephiran is 8-18; N in two n-zephirans is 8-14, and the n in the n-alkyl dimethyl ethylbenzylammonium chloride is 12-18.
Monohydric alcohol described in the component is 95% ethanol.
Dihydroxylic alcohols described in the component is selected from: the ethylene glycol APEO; 1, the 2-dihydroxypropane; The mixture of one or more in 2-ethyl-2-(methylol)-1,3 propane diols etc., wherein the ethylene glycol APEO is an ethylene glycol APEO 200,400,600.
Polyalcohol is selected from the component described in the component: the mixture of one or more of trihydroxy propane, triethylene-glycol, tetraethylene-glycol etc.
Water described in the component is deionized water.
Another object of the present invention is; A kind of compound method of composite disinfecting Alevaire is provided; It mainly is to adopt guanidine compound, quaternary ammonium compound, 2-bromo-2-nitro-1, ammediol, the upright imperial B of holder, monohydric alcohol, dihydroxylic alcohols, polynary alcohol and water through mix, reaction, stir, leave standstill and be prepared from:
The compound method of the above-mentioned composite disinfecting Alevaire that contains the mass percent component is following:
1, with guanidine compound, quaternary ammonium compound, 2-bromo-2-nitro-1, ammediol and Tuo Li dragon B mixes stirring by 50% water of above-mentioned mass percent and above-mentioned mass percent and was mixed with compounding substances A in 3 hours;
2, monohydric alcohol, dihydroxylic alcohols and polyalcohol are mixed stirring by above-mentioned mass percent with the water of above-mentioned mass percent remaining 50% and be mixed with compounding substances B in 3 hours;
3, with said mixture matter A and said mixture matter B stirring reaction 2 hours, left standstill again 2 hours, mixed mixture is carried out assay, qualified mixture is packed, be qualified products.
The object of the invention also comprises the application that above-mentioned composite disinfecting Alevaire is provided:
1, is applied to the sterilization of body surface, air-conditioning system, environment and the air of public health field, food processing field and medicine and hygiene fields through multi-functional ultra micron atomizer, can effectively prevents and kill vegetative forms of bacteria, mycobacterium, virus, fungi and spore thereof etc.;
2, be applied to the sterilization of air, body surface and the air-conditioning system of automotive interior through multi-functional ultra micron atomizer, can effectively prevent and kill vegetative forms of bacteria, mycobacterium, virus etc.;
3, be applied to check the internal container of checking system through multi-functional ultra micron atomizer; The sterilization of the air sterillization of railway carriage, cabin, automotive interior, sterilisation of objects and environment can effectively prevent and kill vegetative forms of bacteria, mycobacterium, virus etc.;
4, be applied to the environment in livestock and poultry cultivation field, the sterilization of indoor and body surface through multi-functional ultra micron atomizer, can effectively prevent and kill vegetative forms of bacteria, mycobacterium, virus, fungi and spore thereof etc.
Combination matching between each component of composite disinfecting Alevaire of the present invention has the effect of Synergistic, and has following advantage and good effect:
1, harmless to people, animal, can not produce harmful substance, do not pollute the environment safety and environmental protection;
2, non-stimulated to skin and mucosa, article and fabric are not had corrosivity;
3, have no irritating odor, colourless, be not subjected to the influence of environment, organic matter, acid, alkali and other physics, chemical factor.
Have an experimental study that sterilization and the compound Alevaire product of desinsection carry out to according to the invention:
The disinfectant of experimental example 1 said component and the sterilization experiment of one-component thimerosal contrast (cooperative synergism effect experiment):
1, the prescription of the sanitizing composition in one-component disinfectant and the component is formed:
| Component | Prescription |
| A | Be dodecyl benzyl dimethyl ammonium chloride |
| B | Be polyhexamethylene guanide |
| A+B | The combination of consumption (or content) separately separately for A and B |
2, experimental result:
| Component | Content | 1min kills logarithm value to Escherichia coli |
| A (quaternary ammonium compound) | 100ppm | ＞ 1.2 |
| B (guanidine compound) | 100ppm | ＞ 1.0 |
| A+B | ? | ＞ 3.0 |
Investigate by above-mentioned experimental technique; When quaternary ammonium compound wherein is selected from: (wherein the n in the n-zephiran is 8-18 to the mixture of one or more in benzalkonium bromide, benzalkonium chloride, n-zephiran, n-alkyl dimethyl ethylbenzylammonium chloride and the two n-alkyl-dimethyl ammonium chloride; N in two n-alkyl-dimethyl ammonium chlorides is 8-14, and the n in the n-alkyl dimethyl ethylbenzylammonium chloride is 12 ~ 18); Guanidine compound is selected from: polyhexamethylene guanide; The mixture of one or more in the hexamethylene; Or when being selected from the mixture of above-mentioned guanidine compound and polyhexamethylene guanide; Also obtained effect like the same Synergistic of experimental example 1 (cooperative synergism effect experiment); Promptly ideal with the sterilization effect of A+B; Simultaneously; The combining form of the A+B of described product is being investigated bacterial propagule; Mycobacterium; Virus; Killing in the process of fungi etc.; The Disinfection Effect that has equally also shown the good Synergistic of A+B combination; Be that special feature of the present invention is; In the component by after the combination of quarternary ammonium salt compound and guanidine compound; It is active that it has outstanding disinfection, and this activity is to be predicted out by the bactericidal action of known single component.
The experimental study that 2 pairs of composite disinfecting Alevaire products according to the invention of Test Example carry out:
1, to the killing effect of staphylococcus aureus (ATCC 6538)
Annotate: average clump count of positive control and scope: 14610000cfu/ml (12200000 cfu/ml ~ 16200000 cfu/ml)
2, to the killing effect of Escherichia coli (8099)
Annotate: average clump count of positive control and scope: 14400000cfu/ml (12950000 cfu/ml ~ 17050000 cfu/ml)
3, to influenza virus, the viral killing effect of HIV:
4, the air of doing in certain hospital and the field trial of body surface
Embodiment
Embodiment 1
| Component | Kilogram kg | Mass percent % |
| Polyhexamethylene guanide | 0.3 kg | 0.3 % |
| Benzalkonium bromide | 0.7 kg | 0.7 % |
| Tuo Lilong B | 0.03 kg | 0.03 % |
| 2-bromo-2-nitro-1, ammediol | 0.1 kg | 0.1 % |
| 95% ethanol | 0.5 kg | 0.5 % |
| 1, the 2-dihydroxypropane | 20 kg | 20 % |
| Trihydroxy propane | 10 kg | 10 % |
| Water | 68.37 kg | 68.37 % |
| Amount to | 100 kg | 100 % |
1) with polyhexamethylene guanide, benzalkonium bromide, 2-bromo-2-nitro-1, ammediol and Tuo Li dragon B mixes stirring by 50% water of above-mentioned mass percent and above-mentioned mass percent and was mixed with compounding substances A in 3 hours;
2) with 95% ethanol, 1,2-dihydroxypropane and trihydroxy propane mix stirring by above-mentioned mass percent and were mixed with compounding substances B in 3 hours with the water of above-mentioned mass percent remaining 50%;
3) with said mixture matter A and said mixture matter B stirring reaction 2 hours, left standstill again 2 hours, mixed mixture is carried out assay, qualified mixture is packed, be qualified products.
Embodiment 2
| Component | Kilogram kg | Mass percent % |
| Poly hexamethylene biguanide | 0.3 kg | 0.3 % |
| Dodecyl benzyl dimethyl ammonium chloride | 0.35 kg | 0.35% |
| Two certain herbaceous plants with big flowers base alkyl dimethyl ammonium chlorides | 0.35kg | 0.35% |
| Tuo Lilong B | 0.03 kg | 0.03 % |
| 2-bromo-2-nitro-1, ammediol | 0.1 kg | 0.1 % |
| 95% ethanol | 0.5 kg | 0.5 % |
| 2-ethyl-2-(methylol)-1,3 propane diols | 20 kg | 20 % |
| Triethylene-glycol | 10 kg | 10 % |
| Water | 68.37 kg | 68.37 % |
| Amount to | 100 kg | 100 % |
1) with poly hexamethylene biguanide, dodecyl benzyl dimethyl ammonium chloride, two certain herbaceous plants with big flowers base alkyl dimethyl ammonium chloride, 2-bromo-2-nitro-1, ammediol and Tuo Li dragon B mix stirring by 50% water of above-mentioned mass percent and above-mentioned mass percent and were mixed with compounding substances A in 3 hours;
2) 95% ethanol, 2-ethyl-2-(methylol)-1,3 propane diols and triethylene-glycol are mixed stirring by above-mentioned mass percent with the water of above-mentioned mass percent remaining 50% and be mixed with compounding substances B in 3 hours;
3) with said mixture matter A and said mixture matter B stirring reaction 2 hours, left standstill again 2 hours, mixed mixture is carried out assay, qualified mixture is packed, be qualified products.
Embodiment 3
| Component | Kilogram kg | Mass percent % |
| Polyhexamethylene guanide | 0.2 kg | 0.2 % |
| Poly hexamethylene biguanide | 0.2kg | 0.2% |
| Two ten zephirans | 0.6 kg | 0.6 % |
| Tuo Lilong B | 0.03 kg | 0.03 % |
| 2-bromo-2-nitro-1, ammediol | 0.1 kg | 0.1 % |
| 95% ethanol | 0.5 kg | 0.5 % |
| 2-ethyl-2-(methylol)-1,3 propane diols | 10 kg | 10 % |
| Triethylene-glycol | 10 kg | 10 % |
| Water | 78.37 kg | 78.37 % |
| Amount to | 100 kg | 100 % |
1) with polyhexamethylene guanide, poly hexamethylene biguanide, two ten zephirans, 2-bromo-2-nitro-1, ammediol and Tuo Li dragon B mixes stirring by 50% water of above-mentioned mass percent and above-mentioned mass percent and was mixed with compounding substances A in 3 hours;
2) 95% ethanol, 2-ethyl-2-(methylol)-1,3 propane diols and triethylene-glycol are mixed stirring by above-mentioned mass percent with the water of above-mentioned mass percent remaining 50% and be mixed with compounding substances B in 3 hours;
3) with said mixture matter A and said mixture matter B stirring reaction 2 hours, left standstill again 2 hours, mixed mixture is carried out assay, qualified mixture is packed, be qualified products.
Embodiment 4
| Component | Kilogram kg | Mass percent % |
| Polyhexamethylene guanide | 0.2 kg | 0.2 % |
| Poly hexamethylene biguanide | 0.2 kg | 0.2 % |
| Two ten alkyl-dimethyl ammonium chlorides | 0.3 kg | 0.3 % |
| The dodecyl dimethyl ethylbenzylammonium chloride | 0.3 kg | 0.3 % |
| Tuo Lilong B | 0.03 kg | 0.03 % |
| 2-bromo-2-nitro-1, ammediol | 0.1 kg | 0.1 % |
| 95% ethanol | 0.5 kg | 0.5 % |
| 1, the 2-dihydroxypropane | 10 kg | 10 % |
| Trihydroxy propane | 10 kg | 10 % |
| Water | 78.37 kg | 78.37 % |
| Amount to | 100 kg | 100 % |
1) with polyhexamethylene guanide, poly hexamethylene biguanide, two ten alkyl-dimethyl ammonium chlorides, dodecyl dimethyl ethylbenzylammonium chloride, 2-bromo-2-nitro-1, ammediol and Tuo Li dragon B mixes stirring by 50% water of above-mentioned mass percent and above-mentioned mass percent and was mixed with compounding substances A in 3 hours;
2) with 95% ethanol, 1,2-dihydroxypropane and trihydroxy propane mix stirring by above-mentioned mass percent and were mixed with compounding substances B in 3 hours with the water of above-mentioned mass percent remaining 50%;
3) with said mixture matter A and said mixture matter B stirring reaction 2 hours, left standstill again 2 hours, mixed mixture is carried out assay, qualified mixture is packed, be qualified products.
Embodiment 5
| Component | Kilogram kg | Mass percent % |
| Poly hexamethylene biguanide | 0.4 kg | 0.4 % |
| Cetalkonium chloride | 0.6 kg | 0.6 % |
| Tuo Lilong B | 0.03 kg | 0.03 % |
| 2-bromo-2-nitro-1, ammediol | 0.1 kg | 0.1 % |
| 95% ethanol | 0.5 kg | 0.5 % |
| 1, the 2-dihydroxypropane | 10 kg | 10 % |
| Trihydroxy propane | 10 kg | 10 % |
| Water | 78.37 kg | 78.37 % |
| Amount to | 100 kg | 100 % |
1) with poly hexamethylene biguanide, cetalkonium chloride, 2-bromo-2-nitro-1, ammediol and Tuo Li dragon B mixes stirring by 50% water of above-mentioned mass percent and above-mentioned mass percent and was mixed with compounding substances A in 3 hours;
2) with 95% ethanol, 1,2-dihydroxypropane and trihydroxy propane mix stirring by above-mentioned mass percent and were mixed with compounding substances B in 3 hours with the water of above-mentioned mass percent remaining 50%;
3) with said mixture matter A and said mixture matter B stirring reaction 2 hours, left standstill again 2 hours, mixed mixture is carried out assay, qualified mixture is packed, be qualified products.
Embodiment 6
| Component | Kilogram kg | Mass percent % |
| Poly hexamethylene biguanide | 0.4 kg | 0.4 % |
| Cetalkonium chloride | 0.6 kg | 0.6 % |
| Tuo Lilong B | 0.03 kg | 0.03 % |
| 2-bromo-2-nitro-1, ammediol | 0.1 kg | 0.1 % |
| 95% ethanol | 0.5 kg | 0.5 % |
| Ethylene glycol APEO 200 | 20 kg | 20 % |
| Tetraethylene-glycol | 10 kg | 10 % |
| Water | 68.37 kg | 68.37 % |
| Amount to | 100 kg | 100 % |
1) with poly hexamethylene biguanide, cetalkonium chloride, 2-bromo-2-nitro-1, ammediol and Tuo Li dragon B mixes stirring by 50% water of above-mentioned mass percent and above-mentioned mass percent and was mixed with compounding substances A in 3 hours;
2) 95% ethanol, ethylene glycol APEO 200 and tetraethylene-glycol are mixed stirring by above-mentioned mass percent with the water of above-mentioned mass percent remaining 50% and be mixed with compounding substances B in 3 hours;
3) with said mixture matter A and said mixture matter B stirring reaction 2 hours, left standstill again 2 hours, mixed mixture is carried out assay, qualified mixture is packed, be qualified products.
Embodiment 7
| Component | Kilogram kg | Mass percent % |
| Poly hexamethylene biguanide | 0.4 kg | 0.4 % |
| Two octyldimethyl benzyl ammonium chlorides | 0.6 kg | 0.6 % |
| Tuo Lilong B | 0.03 kg | 0.03 % |
| 2-bromo-2-nitro-1, ammediol | 0.1 kg | 0.1 % |
| 95% ethanol | 0.5 kg | 0.5 % |
| 1, the 2-dihydroxypropane | 30 kg | 30 % |
| Trihydroxy propane | 10 kg | 10 % |
| Water | 58.37 kg | 58.37 % |
| Amount to | 100 kg | 100 % |
1) with poly hexamethylene biguanide, two octyldimethyl benzyl ammonium chloride, 2-bromo-2-nitro-1, ammediol and Tuo Li dragon B mixes stirring by 50% water of above-mentioned mass percent and above-mentioned mass percent and was mixed with compounding substances A in 3 hours;
2) with 95% ethanol, 1,2-dihydroxypropane and trihydroxy propane mix stirring by above-mentioned mass percent and were mixed with compounding substances B in 3 hours with the water of above-mentioned mass percent remaining 50%;
3) with said mixture matter A and said mixture matter B stirring reaction 2 hours, left standstill again 2 hours, mixed mixture is carried out assay, qualified mixture is packed, be qualified products.
The present invention does further elaboration through above embodiment, but does not limit the scope of the invention.
The present invention is with the various variations of described scope of soverlay technique scheme and claim scope; Under the prerequisite that does not depart from technical scheme of the present invention, any improvement that those skilled in the art that the present invention did are realized easily all belongs to the present invention's scope required for protection.
Claims (10)
1. composite disinfecting Alevaire is characterized in that this composite disinfecting Alevaire comprises following component by mass percent:
。
2. composite disinfecting Alevaire as claimed in claim 1 is characterized in that comprising following most preferably component by mass percent:
。
3. composite disinfecting Alevaire as claimed in claim 1; It is characterized in that guanidine compound is selected from the said component: the mixture of one or more in polyhexamethylene guanide, the poly hexamethylene biguanide etc., or one or more mixture of above-mentioned guanidine compound pharmaceutically acceptable salt.
4. composite disinfecting Alevaire as claimed in claim 1; It is characterized in that described quaternary ammonium compound is selected from: the mixture of one or more in n-zephiran, n-alkyl dimethyl ethylbenzylammonium chloride, two n-zephiran, benzalkonium bromide and the benzalkonium chloride etc.; Wherein the n in the n-zephiran is 8-18; N in two n-zephirans is 8-14, and the n in the n-alkyl dimethyl ethylbenzylammonium chloride is 12-18.
5. composite disinfecting Alevaire as claimed in claim 1 is characterized in that described monohydric alcohol is: 95% ethanol.
6. composite disinfecting Alevaire as claimed in claim 1; It is characterized in that described dihydroxylic alcohols is: 1; 2-dihydroxypropane, 2-ethyl-2-(methylol)-1; The mixture of one or more of 3 propane diols, ethylene glycol APEO etc., wherein the ethylene glycol APEO is an ethylene glycol APEO 200,400,600.
7. composite disinfecting Alevaire as claimed in claim 1 is characterized in that described polyalcohol is: the mixture of one or more of trihydroxy propane, triethylene-glycol, tetraethylene-glycol etc.
8. composite disinfecting Alevaire as claimed in claim 1 is characterized in that described water is: deionized water.
9. application like the described arbitrary composite disinfecting Alevaire of claim 1-8; It is characterized in that: be applied to the sterilization of body surface, air-conditioning system, environment and the air of public health field, food processing field and medicine and hygiene fields through multi-functional ultra micron atomizer, can effectively prevent and kill vegetative forms of bacteria, mycobacterium, virus, fungi and spore thereof etc.; Be applied to the sterilization of air, body surface and the air-conditioning system of automotive interior through multi-functional ultra micron atomizer, can effectively prevent and kill vegetative forms of bacteria, mycobacterium, virus etc.; Be applied to check the internal container of checking system through multi-functional ultra micron atomizer; The sterilization of the air sterillization of railway carriage, cabin, automotive interior, sterilisation of objects and environment can effectively prevent and kill vegetative forms of bacteria, mycobacterium, virus etc.; Be applied to the environment in livestock and poultry cultivation field, the sterilization of indoor and body surface through multi-functional ultra micron atomizer, can effectively prevent and kill vegetative forms of bacteria, mycobacterium, virus, fungi and spore thereof etc.
10. preparation like the described arbitrary composite disinfecting Alevaire of claim 1-8; It is characterized in that: with guanidine compound, quaternary ammonium compound, 2-bromo-2-nitro-1, ammediol and Tuo Li dragon B mixes stirring by 50% water of above-mentioned mass percent and above-mentioned mass percent and was mixed with compounding substances A in 3 hours; Monohydric alcohol, dihydroxylic alcohols and polyalcohol are mixed stirring by above-mentioned mass percent be mixed with compounding substances B in 3 hours with the water of above-mentioned mass percent remaining 50%; With said mixture matter A and said mixture matter B stirring reaction 2 hours, left standstill again 2 hours, mixed mixture is carried out assay, qualified mixture is packed, be qualified products.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110193460A CN102302033A (en) | 2011-07-12 | 2011-07-12 | Preparation and application of compounded disinfection atomization agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110193460A CN102302033A (en) | 2011-07-12 | 2011-07-12 | Preparation and application of compounded disinfection atomization agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102302033A true CN102302033A (en) | 2012-01-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110193460A Pending CN102302033A (en) | 2011-07-12 | 2011-07-12 | Preparation and application of compounded disinfection atomization agent |
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| CN (1) | CN102302033A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106259442A (en) * | 2016-07-19 | 2017-01-04 | 成都科宏达科技有限公司 | A kind of compound disinfectant containing iodine |
| CN108697077A (en) * | 2015-09-25 | 2018-10-23 | 组合块公司 | Polyalcohol, carbohydrate, nucleobase and nucleotide composition and application thereof |
| CN109777639A (en) * | 2019-02-22 | 2019-05-21 | 江苏今日卫生用品有限公司 | It is a kind of for air-conditioning and the disinfection of general object hard surface and the preparation of hygiene and preparation method thereof |
| CN112691118A (en) * | 2021-02-25 | 2021-04-23 | 河南比福制药股份有限公司 | Disinfectant for rhinitis |
| WO2023159278A1 (en) * | 2022-02-28 | 2023-08-31 | Squire Kent Pty Limited | Anti-pathogenic aerosol compositions |
-
2011
- 2011-07-12 CN CN201110193460A patent/CN102302033A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108697077A (en) * | 2015-09-25 | 2018-10-23 | 组合块公司 | Polyalcohol, carbohydrate, nucleobase and nucleotide composition and application thereof |
| CN108697077B (en) * | 2015-09-25 | 2022-04-19 | 组合块公司 | Polyol, carbohydrate, nucleobase and nucleoside compositions and uses thereof |
| US11553713B2 (en) | 2015-09-25 | 2023-01-17 | Chunbo Zhang | Polyalcohol, carbohydrate, nucleobase and nucleotide compositions and uses thereof |
| CN106259442A (en) * | 2016-07-19 | 2017-01-04 | 成都科宏达科技有限公司 | A kind of compound disinfectant containing iodine |
| CN109777639A (en) * | 2019-02-22 | 2019-05-21 | 江苏今日卫生用品有限公司 | It is a kind of for air-conditioning and the disinfection of general object hard surface and the preparation of hygiene and preparation method thereof |
| CN109777639B (en) * | 2019-02-22 | 2021-11-16 | 江苏今日卫生用品有限公司 | Preparation for disinfecting and cleaning hard surface of air conditioner and general objects and preparation method thereof |
| CN112691118A (en) * | 2021-02-25 | 2021-04-23 | 河南比福制药股份有限公司 | Disinfectant for rhinitis |
| WO2023159278A1 (en) * | 2022-02-28 | 2023-08-31 | Squire Kent Pty Limited | Anti-pathogenic aerosol compositions |
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Application publication date: 20120104 |