CN102212126A - 具有抑制内皮细胞生长活性的重组EDI-8t蛋白 - Google Patents
具有抑制内皮细胞生长活性的重组EDI-8t蛋白 Download PDFInfo
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- CN102212126A CN102212126A CN2010101416158A CN201010141615A CN102212126A CN 102212126 A CN102212126 A CN 102212126A CN 2010101416158 A CN2010101416158 A CN 2010101416158A CN 201010141615 A CN201010141615 A CN 201010141615A CN 102212126 A CN102212126 A CN 102212126A
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- polypeptide
- edi
- polynucleotide
- sequence
- cell
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Description
最初的残基 | 代表性的取代 | 优选的取代 |
Ala(A) | Val;Leu;Ile | Val |
Arg(R) | Lys;Gln;Asn | Lys |
Asn(N) | Gln;His;Lys;Arg | Gln |
Asp(D) | Glu | Glu |
Cys(C) | Ser | Ser |
Gln(Q) | Asn | Asn |
Glu(E) | Asp | Asp |
Gly(G) | Pro;Ala | Ala |
His(H) | Asn;Gln;Lys;Arg | Arg |
Ile(I) | Leu;Val;Met;Ala;Phe | Leu |
Leu(L) | Ile;Val;Met;Ala;Phe | Ile |
Lys(K) | Arg;Gln;Asn | Arg |
Met(M) | Leu;Phe;Ile | Leu |
Phe(F) | Leu;Val;Ile;Ala;Tyr | Leu |
Pro(P) | Ala | Ala |
Ser(S) | Thr | Thr |
Thr(T) | Ser | Ser |
Trp(W) | Tyr;Phe | Tyr |
Tyr(Y) | Trp;Phe;Thr;Ser | Phe |
Val(V) | Ile;Leu;Met;Phe;Ala | Leu |
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 201010141615 CN102212126B (zh) | 2010-04-08 | 2010-04-08 | 具有抑制内皮细胞生长活性的重组EDI-8t蛋白 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 201010141615 CN102212126B (zh) | 2010-04-08 | 2010-04-08 | 具有抑制内皮细胞生长活性的重组EDI-8t蛋白 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102212126A true CN102212126A (zh) | 2011-10-12 |
CN102212126B CN102212126B (zh) | 2013-06-19 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN 201010141615 Active CN102212126B (zh) | 2010-04-08 | 2010-04-08 | 具有抑制内皮细胞生长活性的重组EDI-8t蛋白 |
Country Status (1)
Country | Link |
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CN (1) | CN102212126B (zh) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997017988A1 (en) * | 1995-11-13 | 1997-05-22 | Fibrogen, Inc. | Type ix collagen and chimeras |
CN1207046A (zh) * | 1995-11-13 | 1999-02-03 | 菲布洛根有限公司 | Ix型胶原蛋白和嵌合体 |
CN1386753A (zh) * | 2001-05-23 | 2002-12-25 | 中国科学院上海生物化学研究所 | 具有抑制内皮细胞生长活性的重组人内皮生长抑制蛋白 |
CN1884527A (zh) * | 2006-06-09 | 2006-12-27 | 郑金平 | 利用内源性血管生成抑制因子Arresten基因制备蛋白的方法 |
-
2010
- 2010-04-08 CN CN 201010141615 patent/CN102212126B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997017988A1 (en) * | 1995-11-13 | 1997-05-22 | Fibrogen, Inc. | Type ix collagen and chimeras |
CN1207046A (zh) * | 1995-11-13 | 1999-02-03 | 菲布洛根有限公司 | Ix型胶原蛋白和嵌合体 |
CN1386753A (zh) * | 2001-05-23 | 2002-12-25 | 中国科学院上海生物化学研究所 | 具有抑制内皮细胞生长活性的重组人内皮生长抑制蛋白 |
CN1884527A (zh) * | 2006-06-09 | 2006-12-27 | 郑金平 | 利用内源性血管生成抑制因子Arresten基因制备蛋白的方法 |
Also Published As
Publication number | Publication date |
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CN102212126B (zh) | 2013-06-19 |
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