CN102204874B - Anti-halitosis toothpaste containing natural drug compound components - Google Patents
Anti-halitosis toothpaste containing natural drug compound components Download PDFInfo
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Abstract
The invention discloses an anti-halitosis toothpaste containing natural drug compound components, and aims to provide a toothpaste which is capable of effectively inhibiting halitosis pathogens in the oral cavity and efficiently eliminating halitosis, takes natural Chinese herbal medicines as components for eliminating halitosis, and is safe and healthy. The anti-halitosis toothpaste containing the natural drug compound components is composed of toothpaste base materials and an active component compound, wherein the content of the active component compound is 0.601-5.9% in percentage by weight and the balance is the toothpaste base materials; and the active component compound is composed of tea polyphenol, vitamin C, zinc citrate, triclosan and sodium alginate.
Description
Technical field
The present invention relates to a kind of toothpaste, particularly a kind of halitosis toothpaste that contains the composite composition of natural drug.
Background technology
Halitosis is that a kind of universal phenomenon exists in actual life, often perplexs people's problem, and some people is the comparison sensitivity because long-term halitosis becomes, even mental illness occurs, influence and other people normal social communication.The reason that causes halitosis mainly is to exist the negative anaerobe of Ge Shi classes such as porphyromonas gingivalis and helicobacter pylori discharging destruction periodontal tissue such as toxin, enzyme element simultaneously in the oral cavity; Discharge some metabolite: hydrogen sulfide, methanthiol and diethyl sulfide have just formed foul smell in the oral cavity after these metabolite volatilizations.
Toothpaste kind on the market is more now; Have hemostatic, the antiallergic sense, mothproof, pure white, in addition protect gum etc., but these toothpaste are removed the weak effect of halitosis, and the toothpaste of antihalitosis is also arranged; Like publication number is the invention of CN101590000A; Disclose a kind of halitosis-removing toothpaste, constituted, though this toothpaste ability antihalitosis by raw materials such as sorbitol, glycerin, silicon dioxide, sodium lauryl sulphate, HANSHENGJIAO, Oleum menthae, hexadecyltrimethylammonium chloride, essence, deionized waters; But its antihalitosis composition is leading with synthetic chemical, and safety in utilization is not high.
Summary of the invention
The object of the present invention is to provide and a kind ofly can effectively suppress halitosis pathogenic bacterium in the oral cavity, remove the effective toothpaste of halitosis, it as the antihalitosis composition, has safety, healthy characteristics with natural Chinese medicinal herb.
The technical solution adopted for the present invention to solve the technical problems is: a kind of halitosis toothpaste that contains the composite composition of natural drug; Described toothpaste is made up of toothpaste matrix and active component complex; The content of described by weight percentage active component complex is 0.601 ~ 5.9%; Surplus is a toothpaste matrix, and described active component complex is made up of tea polyphenols, vitamin C, zinc citrate, pure as jade pure and mild sodium alginate.
Mentality of designing of the present invention is the active component complex that in conventional toothpaste matrix, adds antihalitosis, obtains the specially good effect halitosis-removing toothpaste, and toothpaste matrix comprises compositions such as wetting agent, abrasivus, foaming agent, thickening agent, sweeting agent, essence and deionized water.
The present invention selects for use with the purity of extracting in the Folium Camelliae sinensis, and to be that sodium alginate and the toothpaste level of zinc citrate, pharmaceutical grade of 99.9% medicinal tea polyphenols, natural complex C, pharmaceutical grade is pure as jade purely remove halitosis as active constituents of medicine.Adopt the medicine Synergistic of tea polyphenols, vitamin C and zinc citrate and pure as jade pure composition; With medicinal sodium alginate as thickening agent; Utilize sodium alginate characteristic (sodium alginate has concentrated solution, forms gel and film forming characteristic) that effective antimicrobial active constituents of medicine can be adsorbed on for a long time around the periodontal cavity; Guarantee to prolong its retention time like this at therapentic part; Active constituents of medicine is slowly discharged with the formula of putting of controlled release long-time continuing, and it is effective and lasting to remove halitosis.
As preferably, by the percentage ratio that accounts for the toothpaste gross weight: polyphenol content is 0.1 ~ 2.5%, and Vitamin C content is 0.01 ~ 1.5%; Zinc citrate content is 0.1 ~ 0.8%; Pure as jade pure content is 0.1 ~ 0.3%, and sodium alginate content is 0.3 ~ 0.8%, and surplus is a toothpaste matrix.Polyphenol content preferred 0.6 ~ 2%.
Tea polyphenols is medicinal tea polyphenols, and vitamin C is natural complex C, and zinc citrate, sodium alginate all are pharmaceutical grade, pure as jade pure be the toothpaste level.That tea polyphenols has is antibiotic, antioxidation, press down enzyme, biological agent such as conjugated protein.Natural complex C is the major physiological function in the oral cavity: promote the biosynthesis of ossein, be beneficial to the healing sooner of tissue injury mouth, promote tooth and skeletal growth, prevent that dental bed is hemorrhage.Zinc citrate and pure as jade pure component: zinc ion has effect antibiotic and the inhibition antibacterial; Pure as jade pure be the high-efficiency broad spectrum antimicrobial; Multiple gram positive bacteria and negative bacterium, fungus and virus all had inhibition and killing action; Have the advantages of good skin compatibility, to the mankind and environment high safety, can be permanently effective inhibition oral cavity bacterium and do not disturb the ecological balance of oral cavity flora.
As preferably, the pH of described halitosis toothpaste is 5.5 ~ 5.8.PH to 5.5 ~ 5.8, effective antimicrobial active constituents of medicine is more stable.The conventional toothpaste matrix of toothpaste matrix preferred acidic of the present invention, as do the toothpaste matrix of quartzy toothpaste, tart conventional toothpaste matrix abrasivus is a silicon dioxide; Therefore acidity is bigger; PH value is low, and effective antimicrobial active constituents of medicine is easy to destroy, and can add alkaline matter through trace and regulate and control toothpaste pH to 5.5 ~ 5.8; Effective so antimicrobial active constituents of medicine is more stable, can make medicine bring into play antihalitosis effect better.Toothpaste matrix of the present invention is if the conventional toothpaste matrix of choosing alkalescence then need not pH.
The invention has the beneficial effects as follows: utilize the medicine Synergistic; With medicinal sodium alginate as thickening agent; Utilize the sodium alginate characteristic that effective antimicrobial active constituents of medicine can be adsorbed on for a long time around the periodontal cavity; Guarantee like this to prolong its retention time at therapentic part, active constituents of medicine is slowly discharged with the formula of putting of controlled release long-time continuing, it is effective and lasting to remove halitosis.The antihalitosis ingredient, safe, healthy.
The specific embodiment
Through specific embodiment, technical scheme of the present invention is further specified below.
Embodiment 1:
In the vacuum Manufacturing medicine extract machine, add tea polyphenols 0.1kg; Vitamin C 1.5kg, zinc citrate 0.8kg, pure as jade pure 0.3kg; Sodium alginate 0.3kg; Toothpaste matrix: wetting agent: sorbitol 58 kg+ Polyethylene Glycol 6.2 kg, abrasivus: silica 18 kg, thickening agent: sodium carboxymethyl cellulose 3 kg, foaming agent: sodium lauryl sulphate 2 kg, sweeting agent: saccharin sodium 0.3 kg, essence 1.5 kg, deionized water 8 kg, stir, regulate lotion of toothpaste pH to 5.5; Carry out the fill sealing after the detection lotion of toothpaste is qualified, make finished product.
Embodiment 2:
In the vacuum Manufacturing medicine extract machine, add tea polyphenols 2.5kg; Vitamin C 0.01kg, zinc citrate 0.1kg, pure as jade pure 0.1kg; Sodium alginate 0.8kg; Toothpaste matrix: wetting agent: sorbitol 55 kg+ glycerol 10 kg, abrasivus: silica 16 kg, thickening agent: xanthan gum 4 kg, foaming agent: sodium lauryl sulphate 3 kg, sweeting agent: saccharin sodium 0.299 kg, essence 1.2 kg, deionized water 7kg, stir, regulate lotion of toothpaste pH to 5.8; Carry out the fill sealing after the detection lotion of toothpaste is qualified, make finished product.
Embodiment 3:
In the vacuum Manufacturing medicine extract machine, add tea polyphenols 2kg, vitamin C 1kg, zinc citrate 0.5kg; Pure as jade pure 0.2kg; Sodium alginate 0.5kg, toothpaste matrix: wetting agent: sorbitol 59.3 kg, abrasivus: silicon dioxide 20 kg, brightening agent: titanium dioxide 0.3kg, thickening agent: carboxymethyl cellulose 4 kg, foaming agent: sodium laurylsulfate 3 kg, sweeting agent: saccharin sodium 0.2 kg, essence 1 kg, deionized water 8kg; Stir; Regulate lotion of toothpaste pH to 5.6, carry out the fill sealing after the detection lotion of toothpaste is qualified, make finished product.
Embodiment 4:
In the vacuum Manufacturing medicine extract machine, add tea polyphenols 0.6kg; Vitamin C 0.5kg, zinc citrate 0.6kg, pure as jade pure 0.3kg; Sodium alginate 0.5kg; Toothpaste matrix: wetting agent: sorbitol 50.3 kg+ Polyethylene Glycol 10 kg, abrasivus: silica 14 kg, brightening agent: titanium dioxide 0.5kg, thickening agent: sodium carboxymethyl cellulose 5.05 kg, foaming agent: sodium laurylsulfate 4 kg, sweeting agent: saccharin sodium 0.15 kg, essence 1.5 kg, deionized water 12kg, regulate lotion of toothpaste pH to 5.7, stir; Carry out the fill sealing after the detection lotion of toothpaste is qualified, make finished product.
Embodiment 5:
In the vacuum Manufacturing medicine extract machine, add tea polyphenols 2kg, vitamin C 1kg, zinc citrate 0.5kg; Pure as jade pure 0.2kg; Sodium alginate 0.5kg, toothpaste matrix: abrasivus: calcium bicarbonate 45 kg, wetting agent: glycerol 23.5 kg, thickening agent: carboxymethyl cellulose 4 kg, foaming agent: sodium lauryl sulphate 3 kg, sweeting agent: saccharin sodium 0.2 kg, essence 1.1 kg, deionized water 19kg stir; Carry out the fill sealing after the detection lotion of toothpaste is qualified, make finished product.
Active component complex of the present invention also can make up with existing other multiple toothpaste matrix and make halitosis toothpaste, does not do one by one at this and enumerates.
Product of the present invention is following through the data that Shanghai Communications University's School of Stomatology detects:
One, to alleviating the test of implication:
1, test method
Portable sulfide monitor (Halimeter) is used in the measurement of implication value, and the experimenter detected and plays the implication value morning in continuous three days, selects implication value height and stable crowd and participates in test.
Experimenter's situation is seen table 1 as the experimenter to choose 30 of qualified implication patients, adopts at random, double blinding, cross-over design test.
The experimenter does not brush teeth first day morning, does not take food, and test plays the implication value morning, uses toothpaste of the present invention and a kind of under doctor's guidance, the brushing teeth 3 minutes that contrasts in the toothpaste (ordinary toothpaste that does not promptly contain active component complex of the present invention) then at random.Baseline is checked back 1.5 hours, 3 hours, requires the experimenter to detect the implication value once more, uses the toothpaste of being provided to brush teeth once before the sleep in evening on the same day.Check back 24 hour at baseline second day morning, detects once more and play implication morning, the phase I off-test.Provide ordinary toothpaste one week of eluting, the test of beginning second stage, step is identical with the phase I test, and difference is intersected for the experimenter and is used toothpaste of the present invention and contrast toothpaste.
2, result of the test
This result of the test shows (seeing table 1): use that (experimental group) 1.5 hours, 3 hours and 24 hours implication values all have remarkable reduction behind the toothpaste of the present invention; And (matched group) 24 hours implication values do not reduce after using contrast toothpaste, and toothpaste of the present invention can effectively suppress implication.
Table 1 experimental group compares with the implication value of different detection times of matched group
Annotate: * representes to have compared statistically-significant difference with baseline value
Two, the test that the halitosis pathogenic bacterium is acted on
1, to the vitro inhibition effects of halitosis pathogenic bacterium:
Measure the inhibition effect of toothpaste of the present invention through external drug sensitive test, observe the growth inhibited situation of toothpaste of the present invention simultaneously Fusobacterium nucleatum reference culture (ATCC 25586), Streptococcus mutans reference culture (ATCC 25175) to halitosis patient saliva anaerobe.
Toothpaste of the present invention is 59% to the average antibacterial percentage rate of halitosis patient saliva anaerobe; Average antibacterial percentage rate to Fusobacterium nucleatum is 93%; Average antibacterial percentage rate to Streptococcus mutans is 97%; Toothpaste of the present invention all has stronger inhibitory action to halitosis malignant bacteria (halitosis patient's saliva anaerobe, Fusobacterium nucleatum); Fungistatic effect is obvious, and toothpaste of the present invention in addition also has than the obvious suppression effect the pathogenic bacterium (Streptococcus mutans) of dental caries, and visible toothpaste of the present invention also has certain dental caries effect.
2, the halitosis pathogenic bacterium are produced the inhibitory action of volatile sulfur compounds (VSCs):
Toothpaste of the present invention is obvious to the inhibitory action that the halitosis malignant bacteria produces volatile sulfur compounds gas with respect to the ordinary toothpaste that does not contain active component complex of the present invention (negative control), suppresses effective, sees table 2 for details.
The inhibitory action that table 2 pair halitosis pathogenic bacterium produce volatile sulfur compounds (VSCs)
Above-described embodiment is the preferable scheme of the present invention, is not the present invention is done any pro forma restriction, under the prerequisite that does not exceed the technical scheme that claim puts down in writing, also has other variant and remodeling.
Claims (3)
1. halitosis toothpaste that contains the composite composition of natural drug, described toothpaste is made up of toothpaste matrix and active component complex, it is characterized in that: the content of described by weight percentage active component complex is 0.601 ~ 5.9%; Surplus is a toothpaste matrix; Described active component complex is made up of tea polyphenols, vitamin C, zinc citrate, pure as jade pure and mild sodium alginate, and by the percentage ratio that accounts for the toothpaste gross weight: polyphenol content is 0.1 ~ 2.5%, and Vitamin C content is 0.01 ~ 1.5%; Zinc citrate content is 0.1 ~ 0.8%; Pure as jade pure content is 0.1 ~ 0.3%, and sodium alginate content is 0.3 ~ 0.8%, and surplus is a toothpaste matrix.
2. the halitosis toothpaste that contains the composite composition of natural drug according to claim 1 is characterized in that: the pH of described halitosis toothpaste is 5.5 ~ 5.8.
3. the halitosis toothpaste that contains the composite composition of natural drug according to claim 1 is characterized in that: polyphenol content is 0.6 ~ 2%.
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| CN102204874B true CN102204874B (en) | 2012-06-27 |
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Cited By (1)
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| EP3389594A4 (en) * | 2015-12-18 | 2019-05-29 | Colgate-Palmolive Company | Sodium zinc alginate structurant and methods for making and using same |
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| CN104257544B (en) * | 2014-09-17 | 2017-05-31 | 名臣健康用品股份有限公司 | A kind of linkage of tetrad method is dispelled halitosis composition toothpaste |
| MX2018013239A (en) * | 2016-05-10 | 2019-02-21 | Colgate Palmolive Co | Alginate dentifrice compositions and methods of making thereof. |
| CN106176376B (en) * | 2016-08-04 | 2020-01-07 | 广州悦创实业有限公司 | Microspheres wrapping tea extract complex and application of microspheres in natural edible toothpaste |
| CN106333900A (en) * | 2016-10-13 | 2017-01-18 | 常州创索新材料科技有限公司 | Method for utilizing sodium alginate to prepare antibacterial and anti-inflammatory toothpaste |
| CN110680788A (en) * | 2019-11-20 | 2020-01-14 | 茗汲(浙江)生物科技有限公司 | Toothpaste containing tea extract and preparation process |
| CN111281834A (en) * | 2020-04-22 | 2020-06-16 | 梅州市和谐生物科技有限公司 | Toothpaste with effects of resisting halitosis and ulcer |
| CN112870110A (en) * | 2021-03-22 | 2021-06-01 | 浙江爱尚日用品有限公司 | Halitosis-resisting toothpaste |
| CN115245468A (en) * | 2022-08-25 | 2022-10-28 | 杭州齿研生物科技有限公司 | Toothpaste capable of removing halitosis caused by periodontal disease |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1225261A (en) * | 1998-04-15 | 1999-08-11 | 贾灏 | Full effective anti dental plaque tooth paste |
| CN1795840A (en) * | 2004-12-24 | 2006-07-05 | 上海利康美瑞药业高科技有限公司 | Oral cavity care product for anti helicobacter pylori of oral cavity and preventing caries function |
| CN101766551B (en) * | 2010-03-30 | 2012-05-30 | 天津天狮生物发展有限公司 | Drug toothpaste for treating oral diseases and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3389594A4 (en) * | 2015-12-18 | 2019-05-29 | Colgate-Palmolive Company | Sodium zinc alginate structurant and methods for making and using same |
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Address after: 322000 Zhejiang city in Jinhua Province town of Yiwu City Road No. 38 poly Patentee after: Zhejiang AI Shang daily necessities Co., Ltd. Address before: 322006 Zhejiang city in Jinhua Province town of Yiwu City Road No. 38 poly Patentee before: Yiwu Aishang Commodity Co.,Ltd. |
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Effective date of registration: 20201221 Address after: 322000 No.38 Juxian Road, Shangxi Town, Yiwu City, Jinhua City, Zhejiang Province Patentee after: Zhejiang Aishan Commodity Co.,Ltd. Patentee after: JILIN AODONG HEALTH TECHNOLOGY Co.,Ltd. Address before: 322000 No.38 Juxian Road, Shangxi Town, Yiwu City, Jinhua City, Zhejiang Province Patentee before: Zhejiang Aishan Commodity Co.,Ltd. |