CN115245468A - Toothpaste capable of removing halitosis caused by periodontal disease - Google Patents
Toothpaste capable of removing halitosis caused by periodontal disease Download PDFInfo
- Publication number
- CN115245468A CN115245468A CN202211027557.5A CN202211027557A CN115245468A CN 115245468 A CN115245468 A CN 115245468A CN 202211027557 A CN202211027557 A CN 202211027557A CN 115245468 A CN115245468 A CN 115245468A
- Authority
- CN
- China
- Prior art keywords
- parts
- toothpaste
- cetylpyridinium chloride
- stirring
- raw materials
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 33
- 239000000606 toothpaste Substances 0.000 title claims abstract description 33
- 206010006326 Breath odour Diseases 0.000 title claims abstract description 14
- 208000032139 Halitosis Diseases 0.000 title claims abstract description 14
- 208000028169 periodontal disease Diseases 0.000 title claims abstract description 11
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims abstract description 22
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims abstract description 22
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 21
- 239000002994 raw material Substances 0.000 claims abstract description 19
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims abstract description 18
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims abstract description 17
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 17
- 239000000811 xylitol Substances 0.000 claims abstract description 17
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract description 17
- 235000010447 xylitol Nutrition 0.000 claims abstract description 17
- 229960002675 xylitol Drugs 0.000 claims abstract description 17
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 15
- 238000003756 stirring Methods 0.000 claims abstract description 15
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract description 14
- 241001122767 Theaceae Species 0.000 claims abstract description 14
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims abstract description 14
- LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 claims abstract description 14
- 150000008442 polyphenolic compounds Chemical class 0.000 claims abstract description 14
- 235000013824 polyphenols Nutrition 0.000 claims abstract description 14
- 229960004029 silicic acid Drugs 0.000 claims abstract description 14
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims abstract description 14
- 239000000600 sorbitol Substances 0.000 claims abstract description 14
- 235000010356 sorbitol Nutrition 0.000 claims abstract description 14
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims abstract description 11
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims abstract description 11
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims abstract description 11
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims abstract description 7
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims abstract description 7
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 7
- 239000004376 Sucralose Substances 0.000 claims abstract description 7
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 claims abstract description 7
- PYIDGJJWBIBVIA-UYTYNIKBSA-N lauryl glucoside Chemical compound CCCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O PYIDGJJWBIBVIA-UYTYNIKBSA-N 0.000 claims abstract description 7
- 229940048848 lauryl glucoside Drugs 0.000 claims abstract description 7
- 239000008108 microcrystalline cellulose Substances 0.000 claims abstract description 7
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract description 7
- 229940016286 microcrystalline cellulose Drugs 0.000 claims abstract description 7
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 7
- 239000011775 sodium fluoride Substances 0.000 claims abstract description 7
- 235000013024 sodium fluoride Nutrition 0.000 claims abstract description 7
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims abstract description 7
- 235000019408 sucralose Nutrition 0.000 claims abstract description 7
- 239000004408 titanium dioxide Substances 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 150000001875 compounds Chemical class 0.000 claims abstract description 6
- 229940073507 cocamidopropyl betaine Drugs 0.000 claims abstract description 5
- 235000011187 glycerol Nutrition 0.000 claims abstract description 5
- 239000008367 deionised water Substances 0.000 claims abstract description 4
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 4
- 238000009849 vacuum degassing Methods 0.000 claims abstract description 4
- 239000000463 material Substances 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 2
- 241000605862 Porphyromonas gingivalis Species 0.000 abstract description 8
- 241000194019 Streptococcus mutans Species 0.000 abstract description 6
- 201000001245 periodontitis Diseases 0.000 abstract description 5
- 230000002401 inhibitory effect Effects 0.000 abstract description 3
- PTHCMJGKKRQCBF-UHFFFAOYSA-N Cellulose, microcrystalline Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC)C(CO)O1 PTHCMJGKKRQCBF-UHFFFAOYSA-N 0.000 abstract 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 235000013772 propylene glycol Nutrition 0.000 abstract 1
- 235000010215 titanium dioxide Nutrition 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 description 13
- 230000000694 effects Effects 0.000 description 8
- 208000002925 dental caries Diseases 0.000 description 6
- 230000003385 bacteriostatic effect Effects 0.000 description 5
- 210000000214 mouth Anatomy 0.000 description 4
- 241000233866 Fungi Species 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 230000000813 microbial effect Effects 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- 241000193403 Clostridium Species 0.000 description 2
- 241000192125 Firmicutes Species 0.000 description 2
- 241000241413 Propolis Species 0.000 description 2
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 229940069949 propolis Drugs 0.000 description 2
- 241000450599 DNA viruses Species 0.000 description 1
- 229920001503 Glucan Polymers 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000003082 abrasive agent Substances 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000002155 anti-virotic effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 102000005936 beta-Galactosidase Human genes 0.000 description 1
- 108010005774 beta-Galactosidase Proteins 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- -1 cationic quaternary ammonium compound Chemical class 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- HEBKCHPVOIAQTA-NGQZWQHPSA-N d-xylitol Chemical compound OC[C@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-NGQZWQHPSA-N 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 241001493065 dsRNA viruses Species 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 239000004088 foaming agent Substances 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Zoology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses toothpaste capable of removing halitosis caused by periodontal disease, which comprises the following compound antibacterial raw materials, xylitol, cetylpyridinium chloride and tea polyphenol, wherein the dosage of the three raw materials is, by weight: 1-10 parts, 0.05-1 part of cetylpyridinium chloride, and the following components in parts by weight: 0.001 to 0.02; the toothpaste also contains other effective components such as glycerol, sorbitol, propylene glycol, hydroxyethyl cellulose, microcrystalline cellulose, hydrated silica, titanium dioxide, sodium fluoride, sucralose, polyethylene glycol, dipotassium glycyrrhizinate, lauryl glucoside, cocamidopropyl betaine, VC, tea polyphenols, and essence; adding sorbitol with a preset amount into deionized water, stirring uniformly, adding hydrated silica, stirring, adding glycerol into hydroxyethyl cellulose, stirring to disperse, adding the rest adjuvants, and vacuum degassing to obtain antibacterial toothpaste. The invention has strong pertinence and obvious inhibiting effect on porphyromonas gingivalis and streptococcus mutans, thereby preventing periodontitis and decayed teeth.
Description
Technical Field
The invention relates to the technical field of toothpaste products, in particular to toothpaste capable of removing halitosis caused by periodontal diseases.
Background
The oral cavity is naturally provided with microbial flora such as bacteria, fungi and the like, which can be divided into gram-positive bacteria and gram-negative bacteria according to types, and can be divided into aerobes, anaerobes and facultative anaerobes according to oxygen demand, wherein the most main pathogenic bacteria are streptococcus mutans and porphyromonas gingivalis.
Porphyromonas gingivalis is a gram-negative bacterium and is liable to cause periodontitis, so that plaque, which is formed by the accumulation of Porphyromonas gingivalis, needs to be controlled in order to control gingivitis.
Mutans streptococci are causative bacteria of dental caries, and are capable of converting sucrose into glucan and converting glucose almost entirely into lactic acid, which is a major cause of dental caries.
The toothpaste is a main product for cleaning oral cavity in daily life, and the toothpaste with antibacterial effect can inhibit microbial flora such as bacteria and fungi in the oral cavity, but the inhibition effect of the currently used toothpaste on the microbial flora such as bacteria and fungi is still imperfect.
Disclosure of Invention
The invention aims to provide toothpaste capable of removing halitosis caused by periodontal disease, which has strong pertinence and obvious inhibition effect on porphyromonas gingivalis and streptococcus mutans, thereby preventing periodontitis and decayed teeth and removing halitosis caused by periodontal disease.
In order to achieve the purpose, the invention provides the following technical scheme:
the toothpaste comprises the following compound antibacterial raw materials, namely propolis, xylitol and cetylpyridinium chloride, wherein the usage amount of the three raw materials is as follows by weight: 0.001 to 0.02, xylitol: 1 to 10 portions of cetylpyridinium chloride and 0.05 to 1 portion of cetylpyridinium chloride.
Cetylpyridinium chloride is a cationic quaternary ammonium compound, porphyromonas gingivalis is a main pathogen causing periodontal problems, is a gram-negative bacterium, and can kill bacteria by the action of cetylpyridinium chloride and a group with negative charges on the cell wall of the porphyromonas gingivalis; 3238 Zxft 3238 clostridium is an anaerobic gram-positive bacterium which can produce volatile sulfide, and can cause halitosis if parasitized in oral cavity, tea polyphenol has broad-spectrum antibacterial and antivirus effects, has obvious bacteriostatic effects on gram-positive bacteria and gram-negative bacteria, and also has obvious killing effects on RNA viruses and DNA viruses, and can weaken the adhesive capacity of Mo Lei clostridium on oral epithelial cells and inhibit the activity of beta-galactosidase related to the production of volatile sulfide; xylitol, also called pentitol, is a sweetener, is white crystal-cleaning powder which is equivalent to sucrose and has lower calorie than sucrose, is an acidic substance which cannot be fermented by dental caries bacteria to cause dental caries, cannot provide nutrition for the bacteria to live, can be accumulated in a cell membrane of the streptococcus mutans in a large amount to generate cytotoxicity to inhibit the growth of the bacteria, and can reduce the adhesive capacity of the streptococcus mutans by using the xylitol for a long time, thereby effectively preventing the dental caries.
In the scheme, the toothpaste prepared by taking tea polyphenol, xylitol and cetylpyridinium chloride (CPC) as compound antibacterial raw materials has good curative effects on relieving red and swollen gums, bleeding gums and inhibiting halitosis, researches show that the antibacterial rate of compound use of the 3 raw materials is much higher than that of single use, and single and matched raw materials are respectively adopted to carry out antibacterial tests under the condition that the bacterial concentration is 1 × 104cfu/ml-9 × 104cfu/ml, so that the data effects shown in the following table are obtained:
therefore, the bacteriostatic effect of the xylitol, the CPC and the tea polyphenol is very obvious.
As a preferable scheme of the invention, the toothpaste comprises the following raw materials in parts by weight: 13-20 parts of sorbitol: 11-15 parts, propylene glycol: 2.5-10 parts of polyethylene glycol: 2-18 parts of hydroxyethyl cellulose: 1.5-2.25 parts of microcrystalline cellulose: 5-10 parts of hydrated silica: 5-15 parts of titanium dioxide: 0.2-2 parts of sodium fluoride: 0.1-0.32 parts of sucralose: 0.1-0.3 part, dipotassium glycyrrhizinate: 0.1 to 0.5 portion, 0.05 to 1 portion of cetylpyridinium chloride, and the weight ratio of lauryl glucoside: 2-5 parts, cocoamidopropyl betaine: 0.5-5 parts, VC: 0.001-0.01 parts of tea polyphenol: 0.001-0.02 parts of xylitol: 1-10 parts, essence: 0.5 to 1.5 percent of the total weight.
In the scheme, the toothpaste adopts various non-ionic foaming agents, humectants, adhesives, abrasives, essence and other raw materials matched with the tea polyphenol, xylitol and cetylpyridinium chloride bacteriostatic combination raw materials, can better exert various effects of the toothpaste, can keep the activity of the bacteriostatic materials besides the bacteriostatic effect, eliminates halitosis caused by periodontitis, and enables breath to be fresh.
As a preferable scheme of the invention, the toothpaste comprises the following raw materials in parts by weight: 13 parts, sorbitol: 11 parts, propylene glycol: 2.5 parts of polyethylene glycol: 3 parts, hydroxyethyl cellulose: 1.8 parts, microcrystalline cellulose: 8.5 parts, hydrated silica: 8 parts of titanium dioxide: 0.3 part, sodium fluoride: 0.32 part, sucralose: 0.14 part, dipotassium glycyrrhizinate: 0.35 parts, cetylpyridinium chloride 0.2 parts, lauryl glucoside: 5.0 parts, cocamidopropyl betaine: 5.0 part, VC:0.006 part, tea polyphenol: 0.02 part, xylitol: 2 parts of essence: 1 percent of the total weight portion.
The preferable scheme of the invention comprises the following preparation method, adding sorbitol with preset amount into deionized water, stirring uniformly, adding hydrated silica, keeping the temperature unchanged, stirring for 10-15 min, adding glycerol into hydroxyethyl cellulose, stirring to disperse, adding the uniformly stirred hydrated silica water/sorbitol solution, stirring to form a viscous state, adding the rest auxiliary materials, and performing vacuum degassing to obtain the antibacterial toothpaste.
Compared with the prior art, the invention has the beneficial effects that:
has strong pertinence, and has obvious inhibiting effect on Porphyromonas gingivalis and Streptococcus mutans, thereby preventing periodontitis and dental caries, and eliminating halitosis caused by periodontal disease.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments, and based on the embodiments of the present invention, all other embodiments obtained by a person skilled in the art without making creative efforts belong to the protection scope of the present invention.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs, and the terms used herein in the specification of the present invention are for the purpose of describing particular embodiments only and are not intended to limit the present invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
The invention provides a technical scheme that:
the toothpaste comprises the following compound antibacterial raw materials, namely propolis, xylitol and cetylpyridinium chloride, wherein the dosage of the three raw materials is as follows by weight: 1 to 10 parts, 0.05 to 1 part of cetylpyridinium chloride, and the weight ratio of tea polyphenol: 0.001 to 0.02 portion.
The toothpaste comprises the following raw materials in parts by weight: 13-20 parts of sorbitol: 11-15 parts, propylene glycol: 2.5-10 parts of hydroxyethyl cellulose: 1.5-2.25 parts, microcrystalline cellulose: 5-10 parts of hydrated silica: 5-15 parts of titanium dioxide: 0.2-2 parts of sodium fluoride: 0.1-0.32 parts of sucralose: 0.1-0.3 part, dipotassium glycyrrhizinate: 0.1 to 0.5 portion, 0.05 to 1 portion of cetylpyridinium chloride, and the following components of polyethylene glycol: 2 to 18, lauryl glucoside: 2-5 parts, cocoamidopropyl betaine: 0.5-5 parts, VC: 0.001-0.01 parts of tea polyphenol: 0.001-0.02 parts of xylitol: 1-10 parts, essence: 0.5 to 1.5 percent of the total weight.
The specific implementation process is as follows: the toothpaste comprises the following raw materials in parts by weight: 13 parts, sorbitol: 11 parts, propylene glycol: 2.5 parts, polyethylene glycol: 3 parts, hydroxyethyl cellulose: 1.8 parts, microcrystalline cellulose: 8.5 parts, hydrated silica: 8 parts of titanium dioxide: 0.3 part, sodium fluoride: 0.32 part, sucralose: 0.14 part, dipotassium glycyrrhizinate: 0.35 parts, cetylpyridinium chloride 0.2 parts, lauryl glucoside: 5.0 parts, cocamidopropyl betaine: 5.0 part, VC:0.006 part, tea polyphenol: 0.02 part, xylitol: 2 parts of essence: 1% of the total weight portion;
adding sorbitol with a preset amount into deionized water, uniformly stirring, adding hydrated silica, keeping the temperature constant, stirring for 10-15 min, adding glycerol into hydroxyethyl cellulose, stirring to disperse, adding the uniformly stirred hydrated silica water/sorbitol solution, stirring to form a viscous state, adding the rest auxiliary materials, and performing vacuum degassing to obtain the antibacterial toothpaste.
The detection indexes of the obtained antibacterial toothpaste are as follows:
the pH value of the antibacterial toothpaste obtained by the scheme is 7.4, and the antibacterial toothpaste belongs to alkaline antibacterial toothpaste.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (4)
1. The toothpaste capable of removing halitosis caused by periodontal disease is characterized by comprising the following compound antibacterial raw materials, xylitol, cetylpyridinium chloride and tea polyphenol, wherein the usage amount of the three raw materials is as follows by weight: 0.001 to 0.02, xylitol: 1 to 10 portions of cetylpyridinium chloride and 0.05 to 1 portion of cetylpyridinium chloride.
2. The toothpaste according to claim 1, for removing halitosis caused by periodontal disease, wherein: the toothpaste comprises the following raw materials in parts by weight: 13-20 parts of sorbitol: 11-15 parts, propylene glycol: 2.5-10 parts of polyethylene glycol: 2 to 18, hydroxyethyl cellulose: 1.5-2.25 parts, microcrystalline cellulose: 5-10 parts of hydrated silica: 5-15 parts of titanium dioxide: 0.2-2 parts of sodium fluoride: 0.1-0.32 parts of sucralose: 0.1-0.3 part, dipotassium glycyrrhizinate: 0.1 to 0.5 portion, 0.05 to 1 portion of cetylpyridinium chloride, lauryl glucoside: 2-5 parts of cocamidopropyl betaine: 0.5-5 parts, VC: 0.001-0.01 part, tea polyphenol: 0.001-0.02 parts of xylitol: 1-10 parts, essence: 0.5 to 1.5 percent of the total weight.
3. The toothpaste according to claim 1 or 2, for removing halitosis caused by periodontal disease, wherein: the toothpaste comprises the following raw materials in parts by weight: 13 parts, sorbitol: 11 parts, propylene glycol: 2.5 parts, polyethylene glycol: 3 parts, hydroxyethyl cellulose: 1.8 parts, microcrystalline cellulose: 8.5 parts, hydrated silica: 8 parts of titanium dioxide: 0.3 part, sodium fluoride: 0.32 part, sucralose: 0.14 part, dipotassium glycyrrhizinate: 0.35 parts, cetylpyridinium chloride 0.2 parts, lauryl glucoside: 5 parts, cocamidopropyl betaine: 4, VC:0.006 part, tea polyphenol: 0.02 part, xylitol: 2 parts of essence: 1 percent of the total weight portion.
4. The toothpaste according to any one of claims 1 to 2, for removing halitosis caused by periodontal disease, wherein: the preparation method comprises the following steps of adding sorbitol with a preset amount into deionized water, uniformly stirring, adding hydrated silica, keeping the temperature constant, stirring for 10-15 min, adding glycerol into hydroxyethyl cellulose, stirring to disperse, adding the uniformly stirred hydrated silica water/sorbitol solution, stirring to form a viscous state, adding the rest auxiliary materials, and performing vacuum degassing to obtain the antibacterial toothpaste.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211027557.5A CN115245468A (en) | 2022-08-25 | 2022-08-25 | Toothpaste capable of removing halitosis caused by periodontal disease |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211027557.5A CN115245468A (en) | 2022-08-25 | 2022-08-25 | Toothpaste capable of removing halitosis caused by periodontal disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115245468A true CN115245468A (en) | 2022-10-28 |
Family
ID=83700074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211027557.5A Pending CN115245468A (en) | 2022-08-25 | 2022-08-25 | Toothpaste capable of removing halitosis caused by periodontal disease |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115245468A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102204874A (en) * | 2011-01-28 | 2011-10-05 | 义乌市爱尚日用品有限公司 | Anti-halitosis toothpaste containing natural drug compound components |
| CN104666185A (en) * | 2015-02-13 | 2015-06-03 | 成都润兴消毒药业有限公司 | Liquid toothpaste and preparation method thereof |
| CN106491389A (en) * | 2017-01-11 | 2017-03-15 | 潍坊医学院 | A kind of shitosan tooth protection children's toothpaste |
| CN108096049A (en) * | 2018-01-18 | 2018-06-01 | 胡茵 | Toothpaste containing amino acid surfactant and cationic bacteriostatic agent and preparation method thereof |
| CN111686035A (en) * | 2020-07-27 | 2020-09-22 | 浙江爱尚日用品有限公司 | Bio-enzyme antibacterial anti-allergy toothpaste |
| CN112870110A (en) * | 2021-03-22 | 2021-06-01 | 浙江爱尚日用品有限公司 | Halitosis-resisting toothpaste |
-
2022
- 2022-08-25 CN CN202211027557.5A patent/CN115245468A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102204874A (en) * | 2011-01-28 | 2011-10-05 | 义乌市爱尚日用品有限公司 | Anti-halitosis toothpaste containing natural drug compound components |
| CN104666185A (en) * | 2015-02-13 | 2015-06-03 | 成都润兴消毒药业有限公司 | Liquid toothpaste and preparation method thereof |
| CN106491389A (en) * | 2017-01-11 | 2017-03-15 | 潍坊医学院 | A kind of shitosan tooth protection children's toothpaste |
| CN108096049A (en) * | 2018-01-18 | 2018-06-01 | 胡茵 | Toothpaste containing amino acid surfactant and cationic bacteriostatic agent and preparation method thereof |
| CN111686035A (en) * | 2020-07-27 | 2020-09-22 | 浙江爱尚日用品有限公司 | Bio-enzyme antibacterial anti-allergy toothpaste |
| CN112870110A (en) * | 2021-03-22 | 2021-06-01 | 浙江爱尚日用品有限公司 | Halitosis-resisting toothpaste |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11419806B2 (en) | Prebiotic oral care methods using a saccharide | |
| CN107468553B (en) | Dental caries prevention toothpaste | |
| CN106562923B (en) | Oral care composition containing profitable probliotics and its application in toothpaste | |
| EP3086800B1 (en) | Prebiotic oral care compositions containing an alkyl glycoside | |
| CA2257596A1 (en) | Antimicrobial agents for oral hygiene products | |
| CN111450038A (en) | Toothpaste for inhibiting oral helicobacter pylori | |
| KR20160096094A (en) | Oral care composition comprising serine and at least a zinc salt | |
| CN110237024B (en) | Whitening probiotic toothpaste and preparation method thereof | |
| EP0348560A1 (en) | Oral composition | |
| JPH0234322B2 (en) | ||
| US20110318283A1 (en) | Use of antibacterial compounds for the oral cavity hygiene | |
| KR101480690B1 (en) | Oral composition containing natural agent | |
| JPH03240721A (en) | Composition for oral cavity | |
| CN115245468A (en) | Toothpaste capable of removing halitosis caused by periodontal disease | |
| JP2007008843A (en) | Dentifrice composition and method for preventing discoloration of dentifrice composition | |
| KR101756306B1 (en) | Oral composition containing extract of sapindus mukurossi Gaertn | |
| ATTRAMADAL et al. | In vivo antibacterial effect of tin on the oral microflora | |
| KR980008210A (en) | Composition for promoting oral hygiene | |
| CN114795997A (en) | NMN-containing amino acid toothpaste and preparation method thereof | |
| US4364924A (en) | Alkali metal salts of poly(vinylbenzoic acid) as dental plaque barrier agents | |
| KR20030089047A (en) | Composition for enhancing oral health | |
| KR19980075132A (en) | Pharmaceutical composition for the treatment of dental caries and periodontal disease, using as an active ingredient medium-chain fatty acids | |
| WO2020141201A1 (en) | Antibacterial oral compositions | |
| KR100314789B1 (en) | Toothpaste Composition for Curing Dental Caries and Inflammation of Oral Cavity | |
| KR20020082308A (en) | Composition for the mouth containing extraction of Euonymus alatus Sieb |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |