CN102159586A - C-芳基葡糖苷衍生物、其制备方法及其在医药上的应用 - Google Patents

C-芳基葡糖苷衍生物、其制备方法及其在医药上的应用 Download PDF

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CN102159586A
CN102159586A CN201080002682XA CN201080002682A CN102159586A CN 102159586 A CN102159586 A CN 102159586A CN 201080002682X A CN201080002682X A CN 201080002682XA CN 201080002682 A CN201080002682 A CN 201080002682A CN 102159586 A CN102159586 A CN 102159586A
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protective embankment
embankment base
naphthalene
aryl
chloro
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CN102159586B (zh
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邓炳初
杨方龙
沈光远
杨韬
王阳
范江
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Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
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Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

本发明涉及C-芳基葡糖苷衍生物、其制备方法及其在医药上的应用，特别是由通式(I)所示的C-芳基葡糖苷衍生物或其可药用的盐或其所有的立体异构体，其制法或含有该衍生物的药物组合物，和作为治疗剂特别是作为治疗糖尿病等相关疾病的药物的用途，其中通式(I)中的各取代基的定义与说明书中的定义相同。

Description

C-芳基葡糖苷衍生物、其制备方法及其在医药上的应用
PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CN201080002682XA 2009-03-12 2010-03-10 C-芳基葡糖苷衍生物、其制备方法及其在医药上的应用 Expired - Fee Related CN102159586B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201080002682XA CN102159586B (zh) 2009-03-12 2010-03-10 C-芳基葡糖苷衍生物、其制备方法及其在医药上的应用

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN200910047426A CN101830876A (zh) 2009-03-12 2009-03-12 C-芳基葡萄糖苷衍生物、其制备方法及其在医药上的应用
CN200910047426.1 2009-03-12
CN201080002682XA CN102159586B (zh) 2009-03-12 2010-03-10 C-芳基葡糖苷衍生物、其制备方法及其在医药上的应用
PCT/CN2010/000291 WO2010102512A1 (zh) 2009-03-12 2010-03-10 C-芳基葡糖苷衍生物、其制备方法及其在医药上的应用

Publications (2)

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CN102159586A true CN102159586A (zh) 2011-08-17
CN102159586B CN102159586B (zh) 2013-12-04

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CN200910047426A Pending CN101830876A (zh) 2009-03-12 2009-03-12 C-芳基葡萄糖苷衍生物、其制备方法及其在医药上的应用
CN201080002682XA Expired - Fee Related CN102159586B (zh) 2009-03-12 2010-03-10 C-芳基葡糖苷衍生物、其制备方法及其在医药上的应用

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CN200910047426A Pending CN101830876A (zh) 2009-03-12 2009-03-12 C-芳基葡萄糖苷衍生物、其制备方法及其在医药上的应用

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CN (2) CN101830876A (zh)
WO (1) WO2010102512A1 (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR201903445T4 (tr) * 2011-06-01 2019-03-21 Green Cross Corp Sglt2 i̇nhi̇bi̇törleri̇ olarak yeni̇ di̇feni̇lmetan türevleri̇
CN104945363B (zh) * 2014-03-24 2017-09-12 天津药物研究院有限公司 一种制备3‑脱氧苯基c‑糖苷类sglt2抑制剂的制备方法及其中间体
CN105294785A (zh) * 2014-07-02 2016-02-03 上海阳帆医药科技有限公司 C-苯并五元杂芳环类芳基葡萄糖苷衍生物及其制备方法与用途
CN104710486A (zh) * 2015-04-07 2015-06-17 安润医药科技（苏州）有限公司 一种列净类药物的合成方法
CN111471031B (zh) * 2019-01-24 2023-05-16 北京盈科瑞创新药物研究有限公司 一种糖苷类衍生物及其制备方法和应用
CN111471032B (zh) * 2019-01-24 2023-08-01 北京盈科瑞创新药物研究有限公司 一种糖苷类衍生物的合成方法及其中间体和应用
WO2020242253A1 (ko) * 2019-05-30 2020-12-03 동아에스티 주식회사 Sglt-2 억제제인 신규 엠파글리플로진 유도체
CN114736099B (zh) * 2022-05-18 2023-06-06 江苏南大光电材料股份有限公司 1-（叔丁基）-3-氯萘的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004359630A (ja) * 2003-06-06 2004-12-24 Yamanouchi Pharmaceut Co Ltd ジフルオロジフェニルメタン誘導体及びその塩
US20050233988A1 (en) * 2003-08-01 2005-10-20 Tanabe Seiyaku Co., Ltd. Novel compounds
CN1989132A (zh) * 2004-07-27 2007-06-27 中外制药株式会社 新的葡萄糖醇衍生物、其前体药物及其盐、以及含有它的糖尿病治疗药

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080027014A1 (en) * 2006-07-28 2008-01-31 Tanabe Seiyaku Co., Ltd. Novel SGLT inhibitors
CN101463055B (zh) * 2009-01-15 2010-12-08 天津药物研究院 一类o-糖苷化合物、其制备方法和用途

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080319047A1 (en) * 1994-11-29 2008-12-25 Hiroharu Matsuoka Novel Glucitol Derivative, Prodrug Thereof And Salt Thereof, And Therapeutic Agent Containing The Same For Diabetes
JP2004359630A (ja) * 2003-06-06 2004-12-24 Yamanouchi Pharmaceut Co Ltd ジフルオロジフェニルメタン誘導体及びその塩
US20050233988A1 (en) * 2003-08-01 2005-10-20 Tanabe Seiyaku Co., Ltd. Novel compounds
CN1989132A (zh) * 2004-07-27 2007-06-27 中外制药株式会社 新的葡萄糖醇衍生物、其前体药物及其盐、以及含有它的糖尿病治疗药

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Publication number Publication date
CN102159586B (zh) 2013-12-04
CN101830876A (zh) 2010-09-15
WO2010102512A1 (zh) 2010-09-16

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