CN102151263B - Veterinary compound hydrochloric acid injection and preparation method thereof - Google Patents
Veterinary compound hydrochloric acid injection and preparation method thereof Download PDFInfo
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Abstract
The invention relates to veterinary compound hydrochloric acid injection and a preparation method thereof. The veterinary compound hydrochloric acid injection consists of oxytetracycline dihydrate injection, imidocarb and diclofenac sodium; the veterinary compound hydrochloric acid injection per 100 ml comprises the required raw materials of: 10-25g of oxytetracycline dihydrate injection, 1.5-5g of diclofenac sodium, 0.1-0.2g of imidocarb, 0.2-0.6g of sodium formaldehyde sulphoxylate, 5-15g of magnesium chloride, 5-13 ml of ethanolamine and 60-81 ml of organic solvents, wherein the allowance is water for injection. The veterinary compound hydrochloric acid injection has remarkable effect when being used for treating acute respiratory infection caused by eperythrozoon suis, babesiosis and other blood protozoa diseases, porcine respiratory disease complex (PRDC) and swine influenza virus (SIV), airway inflammation induced by porcine reproductive and respiratory syndrome (PRRS), haemophilus parasuis, pasteurella, pleuropneumonia and mycoplasma diseases; and the preparation method is simple and easy to operate, and is suitable for batch production.
Description
Technical field
The present invention relates to a kind of animal compound YANSUAN TUMEISU ZHUSHEYE, be specifically related to a kind of animal compound YANSUAN TUMEISU ZHUSHEYE of forming by OXYTETRACYCLINE HCL BP/USP INJECTABLE GRADE, imidazophenylurea and diclofenac sodium and preparation method thereof.
Background technology
From Doyle in 1932 in India's reported first since the eperythrozoonosis, from the piglet to the farrowing sow, all found Eperythrozoon subsequently in the world.In China, Xu Yaocheng etc. (nineteen eighty-two) have found eperythrozoon suis first in the sick pig blood of South of Jiangsu Province erythroderma after, this disease spreads in the whole nation.Behind the organism infection Eperythrozoon; Not only cause the productivity to descend; Breast, meat production reduce; More serious is that the pig immunity that has infected Eperythrozoon descends, for green channel has been opened in the invasion of other pathogen. cause serious clinical symptoms and death. and bring enormous economic loss for vast animal husbandry Producer, had a strong impact on the development of pig industry.
Patent application CN101062042A (200710052243.X) discloses a kind of long-acting veterinary Ursocycline injection and preparation method thereof; The advantage of this patent is to have introduced synergist TMP, and the product drug effect all meets or exceeds import similar products-vibramycin injection.But this injection is a single preparations of ephedrine, does not have composite effective ingredient.CN101653448A (200910018588.2) discloses veterinary compound terramycin injection and preparation method thereof; This patent is introduced tylosin, sodium camphorsulfonate is processed compound oxytetracycline injection, specially good effect is arranged aspect the respiratory system disease due to treatment poultry antibacterial and mycoplasma infection.This injection is the disease that is directed against poultry respiratory system aspect specially, and is also imprecise to the curative effect of eperythrozoon suis.
Oxytetracycline is a broad ectrum antibiotic, and is effective to the infection that staphylococcus, Hemolytic streptococcus, escherichia coli, pasteurellosis bacillus, anthrax bacillus, mycoplasma, chlamydia, rickettsia etc. cause.Simultaneously also can be used for treating giardiasis and eperythrozoonosis.
Diclofenac sodium is a kind of novel strong effect anti-inflammatory analgesic, and its analgesia, antiinflammatory and refrigeration function are stronger 2～2.5 times than indomethacin, and be stronger 26～50 times than aspirin.Main mechanism is to suppress prostaglandin synthetase, and the prostaglandin biosynthesis is obstructed.Characteristics are strong drug action, and untoward reaction is few, and dosage is little, and individual variation is little.
The derivant that imidazophenylurea belongs to equal diphenyl urea is the chemicals of a kind of novel anti protozoon of animal specific.Its dipropionate generally commonly used clinically or dihydrochloride are made preparation, through muscle or subcutaneous injection, in order to treatment with prevent various babesiosis, giardiasis, african trypanosomiasis, attach erythroderma cytopathy, edge parasitosis and theileriosis etc.Absorb rapidly after the injection and be distributed in body tissue, can reach the blood peak concentration of drug after 1 hour, in kidney, concentrate and absorb with prototype again, detoxifcation (metabolism) so consumption is little and lasting medicine, stimulates little in liver.These article are as special-purpose medicine for animals, and it is little, easy to use to have a consumption, short treating period, characteristics such as drug resistance is low.
Summary of the invention
The objective of the invention is to overcome the deficiency that exists in the prior art and provide a kind of and form compound preparation, treat disease aspect outstanding effect such as ARI that blood protozoacide, respiratory tract disease syndrome (PRDC), swine flue (SIV) such as the burnt worm of eperythrozoon suis cause, respiratory inflammation that reproductive and respiratory syndrome (PRRS) brings out, haemophilus parasuis, pasteurellosis bacillus, pleuropneumonia, mycoplasma and be easy to animal compound YANSUAN TUMEISU ZHUSHEYE of suitability for industrialized production and preparation method thereof with tetramycin hydrochloride, imidazophenylurea and diclofenac sodium.
The objective of the invention is to realize like this:
A kind of animal compound YANSUAN TUMEISU ZHUSHEYE is characterized in that: the required raw material of the every 100ml of animal compound YANSUAN TUMEISU ZHUSHEYE is formed as follows: OXYTETRACYCLINE HCL BP/USP INJECTABLE GRADE 10-25g, diclofenac sodium 1.5-5g; Imidazophenylurea 0.1-0.2g; Sodium formaldehyde sulphoxylate 0.2-0.6g, magnesium chloride 5-15g, ethanolamine 5-13ml; Organic solvent 60-81ml, surplus is a water for injection.
Described organic solvent is for by weight the dimethyl formamide of preparing: Polyethylene Glycol-400=2: 1 or alpha-pyrrolidone: Polyethylene Glycol-400=3: 2.
A kind of method for preparing of above-mentioned animal compound YANSUAN TUMEISU ZHUSHEYE, it is characterized in that: the method for preparing of said injection is following:
1), get 50% organic solvent, add diclofenac sodium and imidazophenylurea, stir and make its dissolving, as
2) get the water for injection of recipe quantity, in addition, add the sodium formaldehyde sulphoxylate of recipe quantity, stir and make it
Dissolve, add the ethanolamine of recipe quantity again, stir; The OXYTETRACYCLINE HCL BP/USP INJECTABLE GRADE that adds recipe quantity again; Stirring makes its dissolving, adds remaining organic solvent again, stirs to make its dissolving; The magnesium chloride that adds recipe quantity again; Stirring makes its dissolving, afterwards as
solution for standby
3),
solution and
solution are mixed; Stir
4), adopt carbon block filter to filter, embedding, 100 ℃ of sterilizations 30 minutes.
Described water for injection is necessary for freshly prepd, the airtight water for injection that is chilled to room temperature of putting.
Said tetramycin hydrochloride joins in the water that contains ethanolamine in the operating process, should slowly add tetramycin hydrochloride, raises to prevent system temperature, and the whole operation process answers hierarchy of control temperature to be lower than 30 ℃.
In the complex reaction process of said oxytetracycline with magnesium chloride, answer hierarchy of control temperature about 45 ℃, prevent the too high oxytetracycline degraded that causes of temperature, and guarantee carrying out fast of complex reaction.
The present invention has following good effect:
1) this injection is a kind of compound preparation of being made up of tetramycin hydrochloride, imidazophenylurea and diclofenac sodium; Be used to treat disease aspects such as blood protozoacide such as eperythrozoon suis, burnt worm, respiratory tract disease syndrome (PRDC), ARI that swine flue (SIV) causes, respiratory inflammation that reproductive and respiratory syndrome (PRRS) brings out, haemophilus parasuis, pasteurellosis bacillus, pleuropneumonia, mycoplasma, effect is obvious.
2) method for preparing of this injection is simple to operation, is suitable for large-scale production.
The clinical effectiveness of the present invention aspect the treatment respiratory diseases in pigs:
One, experiment material:
(1) certain company's 20% YANSUAN TUMEISU ZHUSHEYE.
(2) the present invention's 20% YANSUAN TUMEISU ZHUSHEYE.
(3) sterile saline.
(4) 90 pigs of breeding that the acute respiratory symptom is arranged.
Two, experimental program:
Only be divided into three groups at random, blank group, injection sterile saline to the pig that respiratory symptom is arranged; Test one group, certain company's 20% YANSUAN TUMEISU ZHUSHEYE; Test two groups, the present invention's 20% YANSUAN TUMEISU ZHUSHEYE.At the 0th day and the 2nd day, intramuscular injection was 2 times altogether, and dosage is the 15mg/kg body weight.
When the 4th day (treatment tailend) and the 9th day (observation tailend), carrying out the result judges.Judge that successful standard is: (1) apnea difficulty (0 minute); (2) do not have or slightly the cough (0 or 1 minute); (3) do not flow nose liquid (0 minute); (4) nothing or moderate spirit depressed (0 or 1 minute).Total points is above four summations, compares with 0 day, and total points was reduced by at least 2 fens, just calculates and treats successfully.
Three experimental results:
5 death appear in the blank group, and the treatment success rate reaches 20%.Test one group, 3 death occur, the treatment success rate reaches 56%.Test two groups, a no pig phenomena of mortality occur, and the treatment success rate reaches 84%.
The specific embodiment
A kind of animal compound YANSUAN TUMEISU ZHUSHEYE is characterized in that: the required raw material of the every 100ml of animal compound YANSUAN TUMEISU ZHUSHEYE is formed as follows: OXYTETRACYCLINE HCL BP/USP INJECTABLE GRADE 10-25g, diclofenac sodium 1.5-5g; Imidazophenylurea 0.1-0.2g; Sodium formaldehyde sulphoxylate 0.2-0.6g, magnesium chloride 5-15g, ethanolamine 5-13ml; Organic solvent 60-81ml, water for injection is an amount of.
Described organic solvent is for by weight the dimethyl formamide of preparing: Polyethylene Glycol-400=2: 1 or alpha-pyrrolidone: Polyethylene Glycol-400=3: 2.
The present invention reacts a certain amount of ethanolamine earlier with tetramycin hydrochloride, generate a kind of complex, adds organic solvent then, and magnesium chloride carries out complex reaction for another example, and complex dissolves in organic solvent system.
The method for preparing of the injection of said mentioned component and content is following:
1), get 50% organic solvent, add diclofenac sodium and imidazophenylurea, stir and make its dissolving, as
2) get the freshly prepd water for injection of recipe quantity, in addition, add the sodium formaldehyde sulphoxylate of recipe quantity,
Stirring makes its dissolving,
3) add the ethanolamine of recipe quantity, again, stir,
4) OXYTETRACYCLINE HCL BP/USP INJECTABLE GRADE that adds recipe quantity, again stirs and makes its dissolving,
5) add remaining organic solvent, again, stir and make its dissolving,
6) magnesium chloride that, adds recipe quantity again; Stirring makes its dissolving; Afterwards as
solution for standby
7),
solution and
solution are mixed; Stir
8), adopt carbon block filter to filter, embedding, 100 ℃ of sterilizations 30 minutes.
Described water for injection is necessary for freshly prepd, the airtight water for injection that is chilled to room temperature of putting.Said tetramycin hydrochloride joins in the water that contains ethanolamine in the operating process, should slowly add tetramycin hydrochloride, raises to prevent system temperature, and the whole operation process answers hierarchy of control temperature to be lower than 30 ℃.In the complex reaction process of said oxytetracycline with magnesium chloride, answer hierarchy of control temperature about 45 ℃, prevent the too high oxytetracycline degraded that causes of temperature, and guarantee carrying out fast of complex reaction.
Described organic solvent is for by weight the dimethyl formamide of preparing: Polyethylene Glycol-400=2: 1 or alpha-pyrrolidone: Polyethylene Glycol-400=3: 2.
Said tetramycin hydrochloride joins in the water that contains ethanolamine in the operating process, should slowly add tetramycin hydrochloride, raises to prevent system temperature, and the whole operation process answers hierarchy of control temperature to be lower than 30 ℃.Tetramycin hydrochloride joins in the water that contains ethanolamine, can emit a large amount of heat.The high temperature system can be quickened the degraded of oxytetracycline, so in operating process, should slowly add tetramycin hydrochloride, raises to prevent system temperature.
Embodiment 1:A kind of animal compound YANSUAN TUMEISU ZHUSHEYE, its supplementary material composition of the every 100ml of animal compound YANSUAN TUMEISU ZHUSHEYE is following:
Active component: OXYTETRACYCLINE HCL BP/USP INJECTABLE GRADE 25g
Diclofenac sodium 1.5g
Imidazophenylurea 0.1g
Excipient: sodium formaldehyde sulphoxylate 0.2g
Magnesium chloride 5g
Ethanolamine 5ml
Dimethyl formamide 40ml
Polyethylene Glycol-400 20ml
Water for injection 20ml
The preparation process of the injection of mentioned component and content is following:
1), with the dimethyl formamide of 40ml Polyethylene Glycol-400 mix homogeneously with 20ml.--
liquid.
2), get
liquid of 30ml; The diclofenac sodium and the imidazophenylurea that add said amount stir and make dissolving.--I
Liquid (subsequent use).
3) get the new system remarks of recipe quantity, in addition and penetrate water 20ml, add sodium formaldehyde sulphoxylate 0.2g, stir
Mix and make dissolving.
4), add ethanolamine 5ml, stir.
5), add OXYTETRACYCLINE HCL BP/USP INJECTABLE GRADE 25g, stir and make dissolving, obtain yellow clear and bright solution.
6), add remaining
liquid, stir and make evenly.
7), add magnesium chloride 5g, stir and make dissolving.--
liquid
8),
liquid and
liquid are mixed, stir.
9), carbon block filter filters, recording pH is 8.5.Embedding.Sterilized 30 minutes for 100 ℃.Obtain amber
Amber color compound hydrochloric acid Ursocycline injection.
Embodiment 2:A kind of animal compound YANSUAN TUMEISU ZHUSHEYE, its supplementary material composition of the every 100ml of animal compound YANSUAN TUMEISU ZHUSHEYE is following:
Active component: OXYTETRACYCLINE HCL BP/USP INJECTABLE GRADE 10g
Diclofenac sodium 5g
Imidazophenylurea 0.1g
Excipient: sodium formaldehyde sulphoxylate 0.2g
Magnesium chloride 5g
Ethanolamine 5ml
Dimethyl formamide 40ml
Polyethylene Glycol-400 20ml
Water for injection 24ml
According to the amount its preparation method of present embodiment with embodiment 1.
Embodiment 3:A kind of animal compound YANSUAN TUMEISU ZHUSHEYE, its supplementary material composition of the every 100ml of animal compound YANSUAN TUMEISU ZHUSHEYE is following:
Active component: OXYTETRACYCLINE HCL BP/USP INJECTABLE GRADE 10g
Diclofenac sodium 1.5g
Imidazophenylurea 0.2g
Excipient: sodium formaldehyde sulphoxylate 0.2g
Magnesium chloride 5g
Ethanolamine 5ml
Dimethyl formamide 40ml
Polyethylene Glycol-400 20ml
Water for injection 24ml
According to the amount of present embodiment, its preparation method is with embodiment 1.
Embodiment 4:A kind of animal compound YANSUAN TUMEISU ZHUSHEYE, its supplementary material composition of the every 100ml of animal compound YANSUAN TUMEISU ZHUSHEYE is following:
Active component: OXYTETRACYCLINE HCL BP/USP INJECTABLE GRADE 10g
Diclofenac sodium 1.5g
Imidazophenylurea 0.1g
Excipient: sodium formaldehyde sulphoxylate 0.6g
Magnesium chloride 5g
Ethanolamine 5ml
Dimethyl formamide 40ml
Polyethylene Glycol-400 20ml
Water for injection
24Ml
According to the amount of present embodiment, its preparation method is with embodiment 1.
Embodiment 5:A kind of animal compound YANSUAN TUMEISU ZHUSHEYE, its supplementary material composition of the every 100ml of animal compound YANSUAN TUMEISU ZHUSHEYE is following:
Active component: OXYTETRACYCLINE HCL BP/USP INJECTABLE GRADE 10g
Diclofenac sodium 1.5g
Imidazophenylurea 0.1g
Excipient: sodium formaldehyde sulphoxylate 0.2g
Magnesium chloride 15g
Ethanolamine 5ml
Dimethyl formamide 40ml
Polyethylene Glycol-400 20ml
Water for injection 24ml
According to the amount of present embodiment, its preparation method is with embodiment 1.
Embodiment 6:A kind of animal compound YANSUAN TUMEISU ZHUSHEYE, its supplementary material composition of the every 100ml of animal compound YANSUAN TUMEISU ZHUSHEYE is following:
Active component: OXYTETRACYCLINE HCL BP/USP INJECTABLE GRADE 10g
Diclofenac sodium 1.5g
Imidazophenylurea 0.1g
Excipient: sodium formaldehyde sulphoxylate 0.2g
Magnesium chloride 5g
Ethanolamine 13ml
Dimethyl formamide 40ml
Polyethylene Glycol-400 20ml
Water for injection 16ml
According to the amount of present embodiment, its preparation method is with embodiment 1.
Embodiment 7:A kind of animal compound YANSUAN TUMEISU ZHUSHEYE, its supplementary material composition of the every 100ml of animal compound YANSUAN TUMEISU ZHUSHEYE is following:
Active component: OXYTETRACYCLINE HCL BP/USP INJECTABLE GRADE 10g
Diclofenac sodium 1.5g
Imidazophenylurea 0.1g
Excipient: sodium formaldehyde sulphoxylate 0.2g
Magnesium chloride 5g
Ethanolamine 5ml
Dimethyl formamide 54ml
Polyethylene Glycol-400 27ml
Water for injection 10ml
According to the amount of present embodiment, its preparation method is with embodiment 1.
Embodiment 8:A kind of animal compound YANSUAN TUMEISU ZHUSHEYE, its supplementary material composition of the every 100ml of animal compound YANSUAN TUMEISU ZHUSHEYE is following:
Active component: OXYTETRACYCLINE HCL BP/USP INJECTABLE GRADE 25g
Diclofenac sodium 1.5g
Imidazophenylurea 0.1g
Excipient: sodium formaldehyde sulphoxylate 0.2g
Magnesium chloride 5g
Ethanolamine 5ml
Alpha-pyrrolidone 36ml
Polyethylene Glycol-400 24ml
Water for injection 20ml.
The preparation process of this injection is following:
1) with the alpha-pyrrolidone of 36ml Polyethylene Glycol-400 mix homogeneously with 24ml.--
liquid
2) get
liquid of 30ml; The diclofenac sodium and the imidazophenylurea that add said amount stir and make dissolving.--I
liquid (subsequent use)
3) water 20ml penetrated in the new system remarks of getting recipe quantity in addition, adds sodium formaldehyde sulphoxylate 0.2g,
Stirring makes dissolving.
4) add ethanolamine 5ml, stir.
5) add OXYTETRACYCLINE HCL BP/USP INJECTABLE GRADE 25g, stir and make dissolving, obtain yellow clear and bright solution.
6) add remaining
liquid, stirring makes evenly.
7) add magnesium chloride 5g, stir and make dissolving.--
liquid
8)
liquid and
liquid are mixed, stir.
9) carbon block filter filters, and recording pH is 8.5.Embedding.Sterilized 30 minutes for 100 ℃.Obtain amber
Amber color compound hydrochloric acid Ursocycline injection.
Embodiment 9:A kind of animal compound YANSUAN TUMEISU ZHUSHEYE, its supplementary material composition of the every 100ml of animal compound YANSUAN TUMEISU ZHUSHEYE is following:
Active component: OXYTETRACYCLINE HCL BP/USP INJECTABLE GRADE 10g
Diclofenac sodium 5g
Imidazophenylurea 0.1g
Excipient: sodium formaldehyde sulphoxylate 0.2g
Magnesium chloride 5g
Ethanolamine 5ml
Alpha-pyrrolidone 42ml
Polyethylene Glycol-400 28ml
Water for injection 20ml
Method for preparing is with embodiment 8.
Embodiment 10:A kind of animal compound YANSUAN TUMEISU ZHUSHEYE, its supplementary material composition of the every 100ml of animal compound YANSUAN TUMEISU ZHUSHEYE is following:
Active component: OXYTETRACYCLINE HCL BP/USP INJECTABLE GRADE 10g
Diclofenac sodium 1.5g
Imidazophenylurea 0.2g
Excipient: sodium formaldehyde sulphoxylate 0.2g
Magnesium chloride 5g
Ethanolamine 5ml
Alpha-pyrrolidone 42ml
Polyethylene Glycol-400 28ml
Water for injection 20ml
Method for preparing is with embodiment 8.
Embodiment 11:A kind of animal compound YANSUAN TUMEISU ZHUSHEYE, its supplementary material composition of the every 100ml of animal compound YANSUAN TUMEISU ZHUSHEYE is following:
Active component: OXYTETRACYCLINE HCL BP/USP INJECTABLE GRADE 10g
Diclofenac sodium 1.5g
Imidazophenylurea 0.1g
Excipient: sodium formaldehyde sulphoxylate 0.6g
Magnesium chloride 5g
Ethanolamine 5ml
Alpha-pyrrolidone 42ml
Polyethylene Glycol-400 28ml
Water for injection 20ml
Method for preparing is with embodiment 8.
Embodiment 12:A kind of animal compound YANSUAN TUMEISU ZHUSHEYE, its supplementary material composition of the every 100ml of animal compound YANSUAN TUMEISU ZHUSHEYE is following:
Active component: OXYTETRACYCLINE HCL BP/USP INJECTABLE GRADE 10g
Diclofenac sodium 1.5g
Imidazophenylurea 0.1g
Excipient: sodium formaldehyde sulphoxylate 0.2g
Magnesium chloride 15g
Ethanolamine 5ml
Alpha-pyrrolidone 42ml
Polyethylene Glycol-400 28ml
Water for injection 20ml
Method for preparing is with embodiment 8.
Embodiment 13:A kind of animal compound YANSUAN TUMEISU ZHUSHEYE, its supplementary material composition of the every 100ml of animal compound YANSUAN TUMEISU ZHUSHEYE is following:
Active component: OXYTETRACYCLINE HCL BP/USP INJECTABLE GRADE 10g
Diclofenac sodium 1.5g
Imidazophenylurea 0.1g
Excipient: sodium formaldehyde sulphoxylate 0.2g
Magnesium chloride 5g
Ethanolamine 13ml
Alpha-pyrrolidone 37ml
Polyethylene Glycol-400 25ml
Water for injection 20ml
Method for preparing is with embodiment 8.
Embodiment 14:A kind of animal compound YANSUAN TUMEISU ZHUSHEYE, its supplementary material composition of the every 100ml of animal compound YANSUAN TUMEISU ZHUSHEYE is following:
Active component: OXYTETRACYCLINE HCL BP/USP INJECTABLE GRADE 10g
Diclofenac sodium 1.5g
Imidazophenylurea 0.1g
Excipient: sodium formaldehyde sulphoxylate 0.2g
Magnesium chloride 5g
Ethanolamine 5ml
Alpha-pyrrolidone 48ml
Polyethylene Glycol-400 32ml
Water for injection 10ml
Method for preparing is with embodiment 8.
Embodiment 15:A kind of animal compound YANSUAN TUMEISU ZHUSHEYE, its supplementary material composition of the every 100ml of animal compound YANSUAN TUMEISU ZHUSHEYE is following:
Active component: OXYTETRACYCLINE HCL BP/USP INJECTABLE GRADE 20g
Diclofenac sodium 1.5g
Imidazophenylurea 0.1g
Excipient: sodium formaldehyde sulphoxylate 0.5g
Magnesium chloride 10g
Ethanolamine 8ml
Alpha-pyrrolidone 48ml
Polyethylene Glycol-400 32ml
Water for injection 5ml
Method for preparing is with embodiment 8.
Embodiment 16:A kind of animal compound YANSUAN TUMEISU ZHUSHEYE, its supplementary material composition of the every 100ml of animal compound YANSUAN TUMEISU ZHUSHEYE is following:
Active component: OXYTETRACYCLINE HCL BP/USP INJECTABLE GRADE 13g
Diclofenac sodium 1.5g
Imidazophenylurea 0.2g
Excipient: sodium formaldehyde sulphoxylate 0.5g
Magnesium chloride 8g
Ethanolamine 6ml
Dimethyl formamide 54ml
Polyethylene Glycol-200 27ml
Water for injection 10ml
Method for preparing is with embodiment 8.
Embodiment 17:A kind of animal compound YANSUAN TUMEISU ZHUSHEYE, its supplementary material composition of the every 100ml of animal compound YANSUAN TUMEISU ZHUSHEYE is following:
Active component: OXYTETRACYCLINE HCL BP/USP INJECTABLE GRADE 20g
Diclofenac sodium 3g
Imidazophenylurea 0.15g
Excipient: sodium formaldehyde sulphoxylate 0.5g
Magnesium chloride 10g
Ethanolamine 10ml
Alpha-pyrrolidone 42ml
Polyethylene Glycol-400 28ml
Water for injection 20ml
Method for preparing is with embodiment 8.
Claims (5)
1. animal compound YANSUAN TUMEISU ZHUSHEYE; It is characterized in that: the required raw material of the every 100ml of animal compound YANSUAN TUMEISU ZHUSHEYE is formed as follows: OXYTETRACYCLINE HCL BP/USP INJECTABLE GRADE 10-25g, diclofenac sodium 1.5-5g, imidazophenylurea 0.1-0.2g; Sodium formaldehyde sulphoxylate 0.2-0.6g; Magnesium chloride 5-15g, ethanolamine 5-13ml, organic solvent 60-81ml; Surplus is a water for injection, and described organic solvent is for by weight the dimethyl formamide of preparing: Polyethylene Glycol-400=2: 1 or alpha-pyrrolidone: Polyethylene Glycol-400=3: 2.
2. the method for preparing of an animal compound YANSUAN TUMEISU ZHUSHEYE as claimed in claim 1, it is characterized in that: the method for preparing of said injection is following:
1), get 50% organic solvent, add diclofenac sodium and imidazophenylurea, stir and make its dissolving, as the I solution for standby,
2) get the water for injection of recipe quantity, in addition, add the sodium formaldehyde sulphoxylate of recipe quantity, stir and make its dissolving, add the ethanolamine of recipe quantity again; Stir, add the OXYTETRACYCLINE HCL BP/USP INJECTABLE GRADE of recipe quantity again, stir and make its dissolving; Add remaining organic solvent again, stir and make its dissolving, add the magnesium chloride of recipe quantity again; Stirring makes its dissolving, afterwards as the II solution for standby
3), I solution and II solution are mixed, stir,
4), adopt carbon block filter to filter, embedding, 100 ℃ of sterilizations 30 minutes.
3. the method for preparing of animal compound YANSUAN TUMEISU ZHUSHEYE according to claim 3 is characterized in that: described water for injection is necessary for freshly prepd, the airtight water for injection that is chilled to room temperature of putting.
4. the method for preparing of animal compound YANSUAN TUMEISU ZHUSHEYE according to claim 3; It is characterized in that: said tetramycin hydrochloride joins in the water that contains ethanolamine in the operating process; Should slowly add tetramycin hydrochloride; To prevent that system temperature from raising, the whole operation process answers hierarchy of control temperature to be lower than 30 ℃.
5. the method for preparing of animal compound YANSUAN TUMEISU ZHUSHEYE according to claim 3; It is characterized in that: in the complex reaction process of said oxytetracycline with magnesium chloride; Answer hierarchy of control temperature about 45 ℃; Prevent the too high oxytetracycline degraded that causes of temperature, and guarantee carrying out fast of complex reaction.
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| CN105125484A (en) * | 2015-09-02 | 2015-12-09 | 湖南泰谷生物兽药有限公司 | Painless doxycycline injection and preparation method thereof |
| CN109674745B (en) * | 2019-01-23 | 2022-01-04 | 河北远征药业有限公司 | Veterinary compound oxytetracycline hydrochloride injection and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101380301A (en) * | 2008-10-28 | 2009-03-11 | 陈建波 | Compound doxycycline hydrochloride injection for animals and preparation method thereof |
| CN101653448A (en) * | 2009-09-24 | 2010-02-24 | 陈建波 | Veterinary compound terramycin injection and preparation method thereof |
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| CN101953841B (en) * | 2010-09-07 | 2012-03-21 | 西北农林科技大学 | Swine eperythrozoonosis-resisting compound long-acting oxytetracycline injection and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101380301A (en) * | 2008-10-28 | 2009-03-11 | 陈建波 | Compound doxycycline hydrochloride injection for animals and preparation method thereof |
| CN101653448A (en) * | 2009-09-24 | 2010-02-24 | 陈建波 | Veterinary compound terramycin injection and preparation method thereof |
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