CN102144723A - Radix angelicae pubescentis extract feed additive and preparation method thereof - Google Patents
Radix angelicae pubescentis extract feed additive and preparation method thereof Download PDFInfo
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- CN102144723A CN102144723A CN2010101068022A CN201010106802A CN102144723A CN 102144723 A CN102144723 A CN 102144723A CN 2010101068022 A CN2010101068022 A CN 2010101068022A CN 201010106802 A CN201010106802 A CN 201010106802A CN 102144723 A CN102144723 A CN 102144723A
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- extractive
- angelica root
- pubescent angelica
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- root coumarin
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Abstract
The invention discloses a radix angelicae pubescentis extract feed additive and a preparation method thereof. The formulation is formed by circularly extracting roots of the radix angelicae pubescentis for many times, and evenly mixing the extracts with carriers. The preparation method comprises the following steps of: 1, preliminarily extracting the roots of the radix angelicae pubescentis; 2, performing secondary circulated extraction on the residuals of the extraction in the step 1, performing spray drying on the obtain extractum, and mixing the dried extractum with the carriers evenly to form the radix angelicae pubescentis extract feed additive. The radix isatidis extract feed additive has the functions of easing pain, resisting inflammation, resisting bacteria and relieving spasm.
Description
Technical field
The present invention relates to a kind of extractive of pubescent angelica root coumarin feed addictive and preparation method thereof, have the function of analgesia, anti-inflammatory, antibiotic, spasmolysis, belong to natural plants additive technology field.
Background technology
Along with the continuous development of China's aquaculture, the disease of all kinds of cultivated animals has become the outstanding problem of restriction industry development.Only with regard to common communicable disease, its kind is just very complicated, bacteriosis is arranged, parasitic diseases, viral disease or the like.In aquaculture, mainly prevent and treat such disease at present by methods such as vaccine inoculation, medical treatments.
Common vaccine control all is a specific immunity system at animal body at present, specific aim to the cause of disease of other type is not strong, and a kind of vaccine can only prevent a kind of disease, and need be greater than the antibody generation time about a week, because its use needs strict use and management measure, so vaccine control effect aborning is also very limited.Though the vaccine product of One's name is legion is arranged in the market, very different, add improper use in use, make that the effect of vaccine prevention is bad always.Though the medical treatment technology is more effective, also be the mode that mainly prevents of current employing, its side effect is also very outstanding, chemical sproof generation and expansion, multiple medicament residue effect is to pollution of environment or the like.The use of chemicals now also has been subjected to very strict restriction.
Though had Chinese herbal medicine to enter the feed addictive ranks at present, be of rude workmanship, most be direct pulverization process.Its active ingredient is indeterminate, consumption big, it is slow to absorb, onset is slow, and Chinese herbal medicine extract has exactly remedied above shortcoming, has the advantages that consumption is few, target organ clear and definite, effect is fast.Because resources of Chinese medicinal herb is in natural plants, can not produce medicament residue, can not cause bacterium, virus variation, free from environmental pollution etc. characteristics, can play the effect of alternative medicine additive, antibiotic etc.Therefore Chinese herb feed additive has very high research and utilization and is worth in advocating the journey of healthy aquaculture, green cultivation future.
Summary of the invention
The present invention is a raw material with the root of natural levisticum, processing through science, can be the nerve of animal, immunity, internal system provides comprehensive potent trophism, blood-enrich, fast quick-recovery and enhancing animal immune system function, increase the mucus secretory volume of animal body mucous membrane tissue, strengthen the ability that the animal body mucous membrane is secreted multiple IG antibody, strengthen all kinds of activity of immune cells, repair the mucous membrane tissue structure of damaging, thereby resist various germs efficiently, virus, harmful microbe invasion, thereby the incidence of disease of reduction common respiratory tract of livestock and poultry and disease of digestive tract.
Technical scheme of the present invention to achieve these goals is to adopt following means to realize:
A kind of extractive of pubescent angelica root coumarin feed addictive, described extractive of pubescent angelica root coumarin feed addictive is with extractive of pubescent angelica root coumarin 2-4 part; Carrier 3-6 part is formed, by the root of levisticum through forming with appropriate carriers after twice alcohol extract and the spray drying treatment.
The present invention also provides a kind of preparation method of extractive of pubescent angelica root coumarin feed addictive, and concrete steps are as follows:
Respectively the root of levisticum is chosen only, brachymemma, cleaning;
Raw material is packed in the alcohol extracting jar, add 60%～95% ethanol of 3～6 times of weight, boiled 3～6 hours, steam pressure is 0.4～0.7MPa, alcohol reflux;
Filter win the respectively filtrate and first filter residue after the alcohol extracting for the first time; Wherein, first filtrate is reclaimed ethanol by the decompression concentration tank, stop to reclaim until ethanol＜60% that reclaims, the continuation of first filtrate concentrate concentrate;
First filter residue adds 60%～95% ethanol of 3～6 times of weight for the second time, boils steam pressure 0.4～0.7MPa 3～6 hours, alcohol reflux stops to reclaim until ethanol＜60% that reclaims, and filters, get second filtrate and second filter residue respectively, discard second filter residue;
Concentrate, second filtrate are mixed and be concentrated into proportion D=0.9～1.4, promptly get medicinal extract;
The medicinal extract container of packing into refrigerates in 1～5 ℃ and preserves down;
Medicinal extract enters spray dryer, 180 ℃ of EATs, and 70～90 ℃ of leaving air temps promptly get extractive of pubescent angelica root coumarin dry powder;
Extractive of pubescent angelica root coumarin dry powder promptly gets a kind of extractive of pubescent angelica root coumarin feed addictive after mixing with the carrier that is fit to.
Described carrier is preferably at least a in attapulgite, silica, pine needle meal and the maltodextrin.
Described concentrate, first filtrate, second filtrate concentrated is respectively that decompression concentrates or the interlayer concentration tank concentrates.
The present invention has following remarkable advantages and beneficial effect:
1) reduces the animal breath tract disease incidence of disease;
2) generation of control animal alimentary canal ulcer and diarrhea;
3) palatability is strong, improves feed intake, improves feedstuff-meat ratio;
4) natural, noresidue, have no drug resistance, have no side effect.
The specific embodiment
Below in conjunction with specific embodiment the present invention is illustrated:
A kind of extractive of pubescent angelica root coumarin feed addictive is made up of following parts by weight prescription: 2 parts of the extracts of levisticum root; 3 parts in carrier.
A kind of preparation method of extractive of pubescent angelica root coumarin feed addictive, concrete steps are as follows:
Respectively with the root brachymemma of levisticum, clean, choose clean;
Raw material is packed in the alcohol extracting jar, add 60%～95% ethanol of 3～6 times of weight, boiled 3～6 hours, steam pressure is 0.4～0.7MPa, alcohol reflux;
Filter win the respectively filtrate and first filter residue after the alcohol extracting for the first time; Wherein, first filtrate is reclaimed ethanol by the decompression concentration tank, stop to reclaim until ethanol＜60% that reclaims, the continuation of first filtrate concentrate concentrate;
First filter residue adds 60%～95% ethanol of 3～6 times of weight for the second time, boils steam pressure 0.4～0.7MPa 3～6 hours, alcohol reflux stops to reclaim until ethanol＜60% that reclaims, and filters, get second filtrate and second filter residue respectively, discard second filter residue;
Concentrate, second filtrate are mixed and be concentrated into proportion D=0.9～1.4, promptly get medicinal extract;
The medicinal extract container of packing into refrigerates in 1～5 ℃ and preserves down;
Medicinal extract enters spray dryer, 180 ℃ of EATs, and 70～90 ℃ of leaving air temps promptly get extractive of pubescent angelica root coumarin dry powder;
Extractive of pubescent angelica root coumarin dry powder promptly gets a kind of extractive of pubescent angelica root coumarin feed addictive after mixing with the carrier that is fit to.
Chinese herbal medicine is the natural resources of Chinese medicinal materials in China's traditional Chinese veterinary medicine.Levisticum has another name called and solely shakes grass, solely cunning, houseleek, RADIX ANGELICAE PUBESCENTIS from Sichuan of China, meat levisticum, and active ingredient wherein is bergapten.Function with analgesia, anti-inflammatory, antibiotic, spasmolysis can be used for bacillary, mycoplasma breathing problem, enteritis etc., and is green, nontoxic, have no side effect.
Embodiment 1
Specify the present invention below in conjunction with embodiment.
2009.05.10----2009.06.10 during in enormous legendary fish, which could change into a roc Xiang animal experiment field, Shanghai, experimental animal adopts breeds later stage DLY ternary pig.It is as follows to have carried out contrast interpolation result of the test
| Test index | Test group | Control group | Conspicuousness |
| Daily gain (g) | 775 | 780 | - |
| Daily ingestion amount (g) | 2291 | 2384 | - |
| Feedstuff-meat ratio | 2.98 | 3.01 | P＜0.01 |
| Survival rate (%) | 100 | 98 | - |
| The respiratory tract incidence of disease | 21％ | 35％ | P＜0.05 |
| The diarrhea incidence | 19％ | 26％ | P＜0.05 |
Conclusion:
1) reduces the animal breath tract disease incidence of disease;
2) generation of control animal alimentary canal ulcer and diarrhea;
3) palatability is strong, improves feed intake, improves feedstuff-meat ratio;
4) natural, noresidue, have no drug resistance, have no side effect.
During use, can use by spice.During spice, complete feed per ton adds 500～1000g.
It should be noted that at last: above embodiment only in order to the explanation the present invention and and unrestricted technical scheme described in the invention; Therefore, although this specification has been described in detail the present invention with reference to each above-mentioned embodiment,, those of ordinary skill in the art should be appreciated that still and can make amendment or be equal to replacement the present invention; And all do not break away from the technical scheme and the improvement thereof of the spirit and scope of invention, and it all should be encompassed in the middle of the claim scope of the present invention.
Claims (4)
1. extractive of pubescent angelica root coumarin feed addictive, described extractive of pubescent angelica root coumarin feed addictive is a raw material with extractive of pubescent angelica root coumarin and carrier, it is characterized in that: be made up of following formulation by weight ratio: extractive of pubescent angelica root coumarin 2-4 part; Carrier 3-6 part.
2. the preparation method of an extractive of pubescent angelica root coumarin feed addictive is characterized in that: be divided into the following step:
Step 1, respectively the root of raw material levisticum is chosen only, brachymemma, cleaning;
Step 2, raw material is packed in the alcohol extracting jar, add 60%～95% ethanol of 3～6 times of weight, boiled 3～6 hours, steam pressure is 0.4～0.7MPa, alcohol reflux;
Filter win the respectively filtrate and first filter residue after step 3, the alcohol extracting for the first time; Wherein, first filtrate is reclaimed ethanol by the decompression concentration tank, stop to reclaim until ethanol＜60% that reclaims, the continuation of first filtrate concentrate concentrate;
Step 4, first filter residue add 60%～95% ethanol of 3～6 times of weight for the second time, boil steam pressure 0.4～0.7MPa 3～6 hours, alcohol reflux stops to reclaim until ethanol＜60% that reclaims, and filters, get second filtrate and second filter residue respectively, discard second filter residue;
Step 5, concentrate, second filtrate are mixed and be concentrated into proportion D=0.9～1.4, promptly get medicinal extract;
Step 6, the medicinal extract container of packing into refrigerates in 1～5 ℃ and preserves down;
Step 7, medicinal extract enter spray dryer, 180 ℃ of EATs, and 70～90 ℃ of leaving air temps promptly get extractive of pubescent angelica root coumarin dry powder;
Step 9, extractive of pubescent angelica root coumarin dry powder promptly get a kind of extractive of pubescent angelica root coumarin feed addictive after mixing with the carrier that is fit to.
3. a kind of extractive of pubescent angelica root coumarin feed addictive according to claim 1 is characterized in that: described carrier is for being a kind of in pine needle meal, attapulgite, silica, the maltodextrin at least.
4. the preparation method of a kind of extractive of pubescent angelica root coumarin feed addictive according to claim 2 is characterized in that: described concentrate, first filtrate, second filtrate concentrated is respectively that decompression concentrates or the interlayer concentration tank concentrates.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010101068022A CN102144723A (en) | 2010-02-08 | 2010-02-08 | Radix angelicae pubescentis extract feed additive and preparation method thereof |
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| CN2010101068022A CN102144723A (en) | 2010-02-08 | 2010-02-08 | Radix angelicae pubescentis extract feed additive and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108371670A (en) * | 2018-04-02 | 2018-08-07 | 江西中医药大学 | The antibacterial application of decomposite leaf Angelica grosseserrata volatile oil |
Citations (3)
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| US6254897B1 (en) * | 2000-09-11 | 2001-07-03 | Yong Fu Shao | Herbal composition for treatment of tinea infections and method of making same |
| CN1964730A (en) * | 2004-06-09 | 2007-05-16 | 深圳市前仁人科技开发有限公司 | Herbal compositions for prevention and treatment rheumatic and inflammatory diseases and method of preparing the same |
| CN101584745A (en) * | 2009-06-29 | 2009-11-25 | 北京大北农科技集团股份有限公司 | Preparation for new antivirus Chinese medicine formulation for animal |
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2010
- 2010-02-08 CN CN2010101068022A patent/CN102144723A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6254897B1 (en) * | 2000-09-11 | 2001-07-03 | Yong Fu Shao | Herbal composition for treatment of tinea infections and method of making same |
| CN1964730A (en) * | 2004-06-09 | 2007-05-16 | 深圳市前仁人科技开发有限公司 | Herbal compositions for prevention and treatment rheumatic and inflammatory diseases and method of preparing the same |
| CN101584745A (en) * | 2009-06-29 | 2009-11-25 | 北京大北农科技集团股份有限公司 | Preparation for new antivirus Chinese medicine formulation for animal |
Non-Patent Citations (2)
| Title |
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| 袁宗辉，等: "《饲料药物学》", 30 November 2001, 中国农业出版社 * |
| 贾爱珍: "用正交试验法探讨独活的提取", 《陕西中医函授》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108371670A (en) * | 2018-04-02 | 2018-08-07 | 江西中医药大学 | The antibacterial application of decomposite leaf Angelica grosseserrata volatile oil |
| CN108371670B (en) * | 2018-04-02 | 2021-09-24 | 江西中医药大学 | Antibacterial application of pubescent angelica root volatile oil |
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Application publication date: 20110810 |