CN102067853B - Bactericidal composition containing polyoxin and imidazole compound - Google Patents
Bactericidal composition containing polyoxin and imidazole compound Download PDFInfo
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- CN102067853B CN102067853B CN2011100229727A CN201110022972A CN102067853B CN 102067853 B CN102067853 B CN 102067853B CN 2011100229727 A CN2011100229727 A CN 2011100229727A CN 201110022972 A CN201110022972 A CN 201110022972A CN 102067853 B CN102067853 B CN 102067853B
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- polyoxin
- bactericidal composition
- imazalil
- bacterium azoles
- fluorine bacterium
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Abstract
The invention relates to a bactericidal composition containing polyoxin and an imidazole compound. The bactericidal composition comprises the polyoxin and imazalil or triflumizole serving as active ingredients, wherein the weight ratio of the polyoxin to the imazalil or the triflumizole is (64:1)-(1:64); and auxiliary agents and excipients are added into the active ingredients so as to prepare water dispersible granules, wettable powder and the like. The bactericidal composition is used for preventing and controlling diseases caused by ascomycetes, basidiomycetes and fungi inperfect pathogenic bacteria.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of application of combination sterilization composition on crop pest that contains polyoxin and glyoxaline compound.
Technical background
Polyoxin (polyoxin), molecular formula: C
17H
25N
5O
14, chemical name peptide pyrimidine nucleoside.
Structural formula:
Polyoxin broad-spectrum antibiotics class, in having preferably, inhale conduction, its mechanism of action is to disturb the chitinous biosynthesis of bacterial cell wall, and germ tube is with after mycelium contacts medicament, expand part, break, overflow cell inclusion, and can not normal development, cause death, suppress in addition germ and produce spore and scab expansion effect, this medicine does not have toxicity to animal, and plant is not had to poisoning.Main controlling object has wheat powdery mildew, Alternaria alternate, cucumber downy mildew, cucurbits fusarium wilt, black fleck disease of ginseng, cucumber downy mildew, alternaria leaf spot of apple, strawberry and work grape grey mould, the multiple fungal diseases such as forest spike top and Pear black spot.
Imazalil (imazalil) molecular formula: C
14H
14Cl
2N
2O, chemical name: 1-{2-(2,4-dichlorophenyl)-2-(2-propenyloxy group) ethyl }-the 1H-imidazoles.
Imazalil is interior absorption wide-spectrum bactericide, and this medicine affects cell permeability of the membrane, physiological function and lipid anabolism, thereby destroys the cell membrane of mould.The formation of mould fungus inhibition spore simultaneously.
Fluorine bacterium azoles (triflumizole), molecular formula are C
15H
15N
3F
3ClO, chemical name: the chloro-α of (E)-4-, α, the o-toluidines fluorine bacterium azoles of the fluoro-N-of α-tri-(1-imidazoles-1-base-α-third oxygen ethylidene).
Fluorine bacterium azoles is sterol demethylation inhibitor, has the systemic fungicide of protection and therapeutic action.
No matter be polyoxin, imazalil, fluorine bacterium azoles or other efficient germicides, long-term use separately, easily make disease develop immunity to drugs, and causes the problem that dosage strengthens, preventive effect reduces, the lasting period shortens, and is unfavorable for environment sustainable development.The active ingredient of the different mechanisms of action is carried out composite, is to delay the disease method commonly used that develops immunity to drugs, and according to the effect in production application, judge this composite be synergistic effect or antagonism.Complex role is significantly filled a prescription, and can obviously improve preventive effect, greatly reduces the dosage of agricultural chemicals, also can enlarge fungicidal spectrum, improves germicidal efficiency.In the present composition, two kinds of active component mechanism of action points are different, and mutually composite have good synergistic effect within the specific limits.And composite about polyoxin and imazalil or fluorine bacterium azoles, there is not yet relevant report at present at home and abroad.
Summary of the invention
The objective of the invention is to propose a kind of have synergistic function, use cost is low, preventive effect the is good bactericidal composition that contains polyoxin.
The present invention is achieved through the following technical solutions:
A kind of bactericidal composition that contains polyoxin and glyoxaline compound, is characterized in that the weight ratio of bactericidal composition effective active composition polyoxin and imazalil or fluorine bacterium azoles is 64: 1 to 1: 64, and preferred weight ratio is 16: 1 to 1: 16.
Described bactericidal composition is characterized in that: wherein the weight ratio of polyoxin and imazalil is 8: 1 to 1: 8, is preferably 4: 1 to 1: 4.
Described bactericidal composition is characterized in that: wherein the weight ratio of polyoxin and fluorine bacterium azoles is 8: 1 to 1: 8, is preferably 4: 1 to 1: 4.
Amount of application when in the present composition, the content of active component depends on independent use, also depend on mixed ratio and the synergistic effect degree of a kind of compound and another kind of compound, and the while is also relevant with the target fungi.Usually in composition, active weight percentage is 1～90% of gross weight, is preferably 10%～80%.
Bactericidal composition of the present invention, can add corresponding additive and excipient on demand, is processed into acceptable formulation on any agricultural chemicals, and wherein the excellent formulation of selecting is wetting powder, water dispersible granules.
Described auxiliary agent and excipient are selected from: one or more of dispersant, wetting agent, disintegrant, binding agent, filler.
Described dispersant is selected from polycarboxylate, lignosulfonates, the phonetic formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol-polyethenoxy is phonetic, aliphatic amine polyoxyethylene is phonetic, one or more in phonetic of polyoxyethylene carboxylate, ester polyoxyethylene.
Described wetting agent is selected from: one or more in lauryl sodium sulfate, neopelex, Nekal BX, wetting and penetrating agent F, spaonin powder, silkworm excrement, soapberry powder.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, glucose, aluminium chloride.
Described binding agent is selected from: one or more in diatomite, starch, PVA, carboxymethyl (ethyl) cellulose.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, precipitated calcium carbonate.
The described bactericidal composition that contains polyoxin and imazalil or fluorine bacterium azoles, for disease due to the germ that prevents and treats sub-Gammaproteobacteria, Basidiomycetes and Fungi Imperfecti, especially has good preventive effect to downy mildew, gray mold, epidemic disease, powdery mildew, anthracnose, scab, spot defoliation etc.
Beneficial effect of the present invention: (1) present composition effective active composition polyoxin and imazalil or fluorine bacterium azoles belong to the bactericide of two kinds of different mechanisms of action, and both mutually are mixed and can produce conflict; (2) present composition has good synergistic effect within the specific limits, and preventive effect is higher than single dose, and dosage is little; (3) with an organic solvent dosage is few in the present invention, is difficult for producing poisoning, is convenient to transportation and storage; (4) present composition is to having special efficacy to downy mildew, gray mold, epidemic disease, powdery mildew, anthracnose, scab, spot defoliation etc.
Embodiment
To further instruction of the present invention, the percentage in embodiment all is weight percentage below in conjunction with embodiment, but the present invention is not limited thereto.
The embodiment of the present invention is the method that adopts Toxicity Determination and field trial to combine.
Implementation of an application example one the implementation of Formulation Example
Embodiment 1 80% polyoxin triflumizole wettable powder
Polyoxin 10%, fluorine bacterium azoles 70%, polycarboxylate 4%, lauryl sulfate 3%, soapberry powder 2%, starch add to 100%, and mixture carries out air-flow crushing, make 80% polyoxin triflumizole wettable powder.
Embodiment 2 65% polyoxin triflumizole wettable powders
Polyoxin 5%, fluorine bacterium azoles 60%, alkylphenol-polyethenoxy are phonetic 5%, silkworm excrement 3%, white carbon 2%, diatomite add to 100%, and mixture carries out air-flow crushing, makes 65% polyoxin triflumizole wettable powder.
Embodiment 3 30% polyoxin triflumizole wettable powders
Polyoxin 20%, fluorine bacterium azoles 10%, neopelex 3%, lignosulfonates 5%, kaolin add to 100%, and mixture carries out air-flow crushing, make 30% polyoxin triflumizole wettable powder.
Embodiment 4 50% polyoxin triflumizole water dispersants
Polyoxin 20%, fluorine bacterium azoles 30%, alkylphenol-polyethenoxy are phonetic 3%, polyoxyethylene carboxylate 3%, lauryl sodium sulfate 4%, ammonium sulfate 2%, bentonite add to 100%, mix and make 50% polyoxin triflumizole water dispersant.
Embodiment 5 60% polyoxin triflumizole water dispersants
Polyoxin 10%, fluorine bacterium azoles 50%, polycarboxylate 3%, alkylphenol-polyethenoxy are phonetic 2%, lauryl sodium sulfate 4%, sodium bicarbonate 3%, bentonite 8%, kaolin add to 100%, mix and make 60% polyoxin triflumizole water dispersant.
Embodiment 6 10% polyoxin triflumizole water dispersants
Polyoxin 5%, fluorine bacterium azoles 5%, lignosulfonates 4%, DBSA 4%, urea 6%, diatomite add to 100%, mix and make 10% polyoxin triflumizole water dispersant.
Embodiment 7 80% polyoxin imazalil wetting powders
Polyoxin 10%, imazalil 70%, lignosulfonates 5%, spaonin powder 3%, white carbon 10%, starch add to 100%, and mixture carries out air-flow crushing, make 80% polyoxin imazalil wetting powder.
Embodiment 8 60% polyoxin imazalil wetting powders
Polyoxin 20%, imazalil 40%, alkylphenol-polyethenoxy are phonetic 5%, neopelex 3%, white carbon 10%, kaolin add to 100%, and mixture carries out air-flow crushing, makes 60% polyoxin imazalil wetting powder.
Embodiment 9 55% polyoxin imazalil wetting powders
Polyoxin 10%, imazalil 45%, lignosulfonates 5%, wetting and penetrating agent F 3%, white carbon 10%, kaolin add to 100%, and mixture carries out air-flow crushing, make 55% polyoxin imazalil wetting powder.
Embodiment 10 60% polyoxin imazalil water dispersible granules
Polyoxin 10%, imazalil 50%, alkylphenol-polyethenoxy are phonetic 3%, lignosulfonates 3%, lauryl sodium sulfate 2%, white carbon 15%, bentonite add to 100%, mix and make 60% polyoxin imazalil water dispersible granules.
Embodiment 11 40% polyoxin imazalil water dispersible granules
Polyoxin 10%, imazalil 30%, polycarboxylate 3%, polyoxyethylene carboxylate 3%, lauryl sodium sulfate 4%, white carbon 10%, sodium chloride 5%, kaolin add to 100%, mix and make 40% polyoxin imazalil water dispersible granules.
Embodiment 12 48% polyoxin imazalil water dispersible granules
Polyoxin 8%, imazalil 40%, alkylphenol-polyethenoxy are phonetic 5%, dodecyl benzene sulfonate 3%, white carbon 10%, bentonite add to 100%, mix and make 48% polyoxin imazalil water dispersible granules.
Implementation of an application example two: polyoxin and imazalil (or fluorine bacterium azoles) are composite to the bacterium of downy mildew of cucumber Toxicity Determination
Test medicine provides by Shaanxi agricultural chemicals Co., Ltd of U.S. nation.
After the effective inhibition concentration scope of each medicament was determined in prerun, each medicament was established respectively 5 dosage by active constituent content and is processed, and established the clear water contrast.With reference to " farm-chemical indoor determination test rule bactericide ", carry out, adopt the mycelial growth rate method to measure the virulence of medicament to bacterium of downy mildew of cucumber.After 72h, measure colony diameter by the right-angled intersection method, calculate and respectively process net growth, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into to probit value (y), and liquor strength (μ g/mL) converts logarithm value (x) to, tries to achieve virulence regression equation (y=a+bx) with method of least squares, and calculates thus the EC of every kind of medicament
50Value.According to the Wadley method, calculate the different proportioning synergy ratio (SR) of two medicaments simultaneously, SR<0.5 is antagonism, and 0.5≤SR≤1.5 are summation action, and SR>1.5 are synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively polyoxin and imazalil (or fluorine bacterium azoles) shared ratio in composition.
A is polyoxin
B is imazalil or fluorine bacterium azoles
Result of the test is as shown in the table:
Toxicity test result one:
Table 1 polyoxin, imazalil and the composite analysis of results table of toxicity test to bacterium of downy mildew of cucumber thereof
As shown in Table 1, polyoxin, the imazalil EC to bacterium of downy mildew of cucumber
50Be respectively 1.53mg/L and 1.48mg/L.The virulence of polyoxin is lower than the virulence of imazalil.Polyoxin and imazalil were mixed in scope and all show obvious synergistic effect at 64: 1 to 1: 64, and wherein synergistic effect is the most obvious when polyoxin and imazalil weight ratio are in 16: 1 to 1: 16 scopes.
Toxicity test result two:
Table 2 polyoxin, fluorine bacterium azoles and the composite analysis of results table of toxicity test to bacterium of downy mildew of cucumber thereof
As shown in Table 2, polyoxin, the fluorine bacterium azoles EC to bacterium of downy mildew of cucumber
50Be respectively 1.58mg/L and 0.42mg/L.The virulence of polyoxin is lower than the virulence of fluorine bacterium azoles.Polyoxin and fluorine bacterium azoles were mixed in scope and all show obvious synergistic effect at 64: 1 to 1: 64, and wherein synergistic effect is the most obvious when polyoxin and fluorine bacterium azoles weight ratio are in 16: 1 to 1: 16 scopes.
Embodiment applies three polyoxins and imazalil (or fluorine bacterium azoles) and the composite pear scab test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in Weinan City Pucheng County, Shaanxi Province, test medicine is researched and developed, is provided by Shaanxi agricultural chemicals Co., Ltd of U.S. nation, contrast medicament 10% polyoxin wetting powder (commercial), 50% Imazalil EC (commercial), 30% triflumizole wettable powder (commercial).
Investigation pear scab disease index before medicine, in the their early stage dispenser, once, dispenser is 3 times altogether in dispenser in every 7 days, for the third time 7 days, 15 days, 30 days investigation disease indexs calculate preventive effect after dispenser.Experimental result is as follows:
Table 3 polyoxin, imazalil (or fluorine bacterium azoles) and the composite pear scab test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 3, can effectively prevent and treat pear scab after polyoxin and imazalil (or fluorine bacterium azoles) are composite, control efficiency all is better than contrasting medicament, and the lasting period is long.In the test scope of medication, the target crop is had no adverse effects.
Implementation of an application example four polyoxins and imazalil (or fluorine bacterium azoles) and the composite control cucumber downy mildew test of pesticide effectiveness thereof
This experimental establishment is in the Shanggao County, Jiangxi Province, test medicine is researched and developed, is provided by Shaanxi agricultural chemicals Co., Ltd of U.S. nation, contrast medicament 10% polyoxin wetting powder (commercial), 50% Imazalil EC (commercial), 30% triflumizole wettable powder (commercial).
In the dispenser of cucumber downy mildew their early stage, once, dispenser is 2 times altogether in dispenser in every 7 days, and before dispenser, the investigation disease index, investigated respectively disease index in 10 days, 20 days after the 2nd dispenser, and the calculation correction preventive effect, and result of the test is as follows:
Table 4 polyoxin and imazalil (or fluorine bacterium azoles) and the composite control cucumber downy mildew test of pesticide effectiveness thereof
As can be seen from Table 4, polyoxin, imazalil (or fluorine bacterium azoles) can the effectively preventing cucumber downy mildews, and control efficiency all is better than contrasting medicament, and dosage is little, in the test scope of medication to the target crop without harm.
Implementation of an application example five polyoxins, imazalil (or fluorine bacterium azoles) and the composite apple mildew test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in the Liquan County, Shaanxi Province, test medicine is researched and developed, is provided by Shaanxi agricultural chemicals Co., Ltd of U.S. nation, contrast medicament 10% polyoxin wetting powder (commercial), 50% Imazalil EC (commercial), 30% triflumizole wettable powder (commercial).
Investigation apple mildew state of an illness radix, total number of sheets, the sick number of sheets and sick leaf-size class number before medicine, in the their early stage dispenser, once, dispenser is 3 times altogether, investigates respectively disease index and calculates preventive effect in 10 days, 20 days after the last dispenser in dispenser in every 7 days.Experimental result is as follows:
Table 5 polyoxin, imazalil (or fluorine bacterium azoles) and the composite apple mildew test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 5, after polyoxin and imazalil (or fluorine bacterium azoles) are composite, can effectively prevent and treat apple mildew and occur, control efficiency all is better than contrasting medicament, in this test scope of medication, the target crop is had no adverse effects.And alternaria leaf spot of apple is had to preventive effect preferably, preventive effect all reaches more than 90%.
Claims (8)
1. a bactericidal composition that contains polyoxin and glyoxaline compound, is characterized in that the weight ratio of bactericidal composition effective active composition polyoxin and imazalil or fluorine bacterium azoles is 64: 1 to 1: 64.
2. bactericidal composition according to claim 1, it is characterized in that: wherein the weight ratio of polyoxin and imazalil or fluorine bacterium azoles is 16: 1 to 1: 16.
3. bactericidal composition according to claim 2, it is characterized in that: wherein the weight ratio of polyoxin and imazalil is 8: 1 to 1: 8.
4. bactericidal composition according to claim 2, it is characterized in that: wherein the weight ratio of polyoxin and fluorine bacterium azoles is 8: 1 to 1: 8.
5. bactericidal composition according to claim 1, it is characterized in that: wherein the effective active component content accounts for 1～90% of gross weight.
6. bactericidal composition according to claim 5, it is characterized in that: wherein the effective active component content accounts for 10～80% of gross weight.
7. bactericidal composition according to claim 1 is characterized in that: bactericidal composition is for preventing and treating the disease on fruit tree, vegetables and cereal crop.
8. bactericidal composition according to claim 7 is characterized in that: bactericidal composition for control to downy mildew, gray mold, epidemic disease, powdery mildew, anthracnose, scab, spot defoliation.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1759677A (en) * | 2005-11-28 | 2006-04-19 | 北京绿色农华植保科技有限责任公司 | Sterilization composition containing carbendazim of multiple antimycin |
| CN101171919A (en) * | 2007-10-15 | 2008-05-07 | 张少武 | Bactericide agent composition containing active ingredient of epoxiconazole |
| CN101796955A (en) * | 2009-12-31 | 2010-08-11 | 青岛星牌作物科学有限公司 | Composite bactericidal composite and applications thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1759677A (en) * | 2005-11-28 | 2006-04-19 | 北京绿色农华植保科技有限责任公司 | Sterilization composition containing carbendazim of multiple antimycin |
| CN101171919A (en) * | 2007-10-15 | 2008-05-07 | 张少武 | Bactericide agent composition containing active ingredient of epoxiconazole |
| CN101796955A (en) * | 2009-12-31 | 2010-08-11 | 青岛星牌作物科学有限公司 | Composite bactericidal composite and applications thereof |
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Address after: 715500 Pucheng County of Shaanxi Province agricultural base industrial park Patentee after: Shaanxi Meibang Pesticide Co., Ltd. Address before: 710075, C, 15 floor, Jinqiao International Plaza, science and technology road, hi tech Zone, Shaanxi, Xi'an Patentee before: Shaanxi Meibang Pesticide Co., Ltd. |
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Effective date of registration: 20180408 Address after: 226156 Nantong Binhai New Area, Haimen City, Hong Kong West Road, No. 999, No. Patentee after: HAIMEN HUANGHAI PIONEER PARK SERVICES CO., LTD. Address before: 715500 Weinan City, Shaanxi province Pucheng County agricultural base industrial park Patentee before: Shaanxi Meibang Pesticide Co., Ltd. |