CN102028701A - Active ingredient composition for treating alcoholic liver injury - Google Patents
Active ingredient composition for treating alcoholic liver injury Download PDFInfo
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- CN102028701A CN102028701A CN 201010611136 CN201010611136A CN102028701A CN 102028701 A CN102028701 A CN 102028701A CN 201010611136 CN201010611136 CN 201010611136 CN 201010611136 A CN201010611136 A CN 201010611136A CN 102028701 A CN102028701 A CN 102028701A
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Abstract
The invention discloses an active ingredient composition for treating alcoholic liver injury, and relates to an active ingredient composition for treating liver injury. The invention solves the problems that the conventional traditional Chinese medicines and compound decoction thereof for treating liver injury are inconvenient to use, and the dosage and safety are difficult to control. The active ingredient composition for treating the alcoholic liver injury consists of 6,7-dimethoxybenzopyran-2-one, geniposide and parietic acid. The active ingredient composition for treating the alcoholic liver injury has the advantages that: the clinical medicinal dosage is accurate, safe and effective, the active ingredient composition is convenient to use, the treatment effect is improved, medicinal materials are saved, and toxic and side effects are reduced; and the 6,7-dimethoxybenzopyran-2-one, the geniposide and the parietic acid have liver-protecting and gut-benefiting components having the advantages of quick absorption (short time to peak), slow metabolism (longer half life of medicines), higher peak concentration and larger blood concentration area under a curve, so the 6,7-dimethoxybenzopyran-2-one, the geniposide and the parietic acid can serve as preferred active ingredients. The active ingredient composition provides a basis for subsequently preparing finished pharmaceutical products in various formulations.
Description
Technical field
The present invention relates to a kind of combination of active principles for the treatment of hepatic injury.
Background technology
The Chinese medicine and the compound recipe thereof of treatment hepatic injury are fried in shallow oil into decoction, though certain curative effect is arranged, in clinical practice, use inconveniently, and dosage, safety are difficult to control; This class medicament is taken not only time-consuming, boil medicine and be subjected to many condition restriction, such as decocting time, decoct vessel, amount of water, the duration and degree of heating, be decocted first and the inferior method of boiling medicine in back is difficult to grasp, the person of boiling medicine fully by rule of thumb, subjective randomness is very strong, and lacking reliable quality testing and monitoring means, many uncertain factors can't be guaranteed clinical efficacy; And Chinese patent medicine can't be added and subtracted with disease generally just at specific crowd, specific disease, and clinical application has significant limitation.Be difficult to monitoring owing to change in Chinese medicine and the compound recipe complicated component thereof, body.
Summary of the invention
The objective of the invention is to fry in shallow oil into decoction existence use inconvenience for the Chinese medicine and the compound recipe thereof that solve existing treatment hepatic injury, the unmanageable problem of dosage and safety, and a kind of combination of active principles for the treatment of alcoholic liver injury is provided.
The combination of active principles of treatment alcoholic liver injury press ratio of quality and the number of copies by 16～20 parts 6, the chrysophanic acid composition of 7-dimethoxy coumarin, 7～11 parts jasminoidin and 4～8 parts.
The present invention treats the combination of active principles of alcoholic liver injury, and advantage is to guarantee that clinical medicine dose accurately with safe and effective, easy to use, improves curative effect, saves medical material, reduces toxic and side effects.
Characteristics of the present invention: the Chinese medicine and the compound recipe complicated component thereof of treatment hepatic injury, action target spot is a lot, be difficult to the intravital warp-time variation of monitoring, 6,7-dimethoxy coumarin, jasminoidin and chrysophanic acid have absorption fast (peak time is short), metabolism slow (drug half-life is longer), it is higher to reach peak concentration, and the hepatic cholagogic composition that the blood drug level area is bigger under the curve can be used as first-selected active ingredient.
The combination of active principles that the present invention treats alcoholic liver injury provides the basis for the finished product medicament of the various dosage forms of subsequent preparation.
Description of drawings
Fig. 1 is the column spectrogram of Herba Artemisiae Scopariae Decoction lyophilized powder treatment index in the specific embodiment five, wherein K2 is blank solvent, and M2 is the model solvent, and YCHT is the Herba Artemisiae Scopariae Decoction lyophilized powder, 1 expression ALT, 2 expression AST, 3 expression ADH, 4 expression γ-GT, 5 expression TG, 6 expression GSH-Px, 7 expression MDA, 8 expression TP; Fig. 2 is the column spectrogram of the combination of active principles treatment index of treatment alcoholic liver injury in the specific embodiment five, wherein K2 is blank solvent, and M2 is the model solvent, and DGR is the combination of active principles of treatment alcoholic liver injury in the specific embodiment five, 1 expression ALT, 2 expression AST, 3 expression ADH, 4 expression γ-GT, 5 expression TG, 6 expression GSH-Px, 7 expression MDA, 8 expression TP.
The specific embodiment
Technical solution of the present invention is not limited to the following cited specific embodiment, also comprises the combination in any between each specific embodiment.
The specific embodiment one: the combination of active principles of present embodiment treatment alcoholic liver injury press ratio of quality and the number of copies by 16～20 parts 6,7-dimethoxy coumarin, 7～11 parts jasminoidin and 4～8 parts chrysophanic acid composition.
The main performance index of the combination of active principles of treatment alcoholic liver injury in the present embodiment:
1, alanine aminotransferase (ALT) index:
ALT mainly is distributed in the liver cytoplasm, if hepatic necrosis, alanine aminotransferase will raise, and the impaired degree of the degree of its rising and hepatocyte is consistent, therefore is one of at present the most frequently used liver function index.The ALT activity increases prompting hepatocyte destruction, permeability of cell membrane enhancing after giving ethanol.It is disturbed with ALT index correlation coefficient that prompting gives behind the ethanol rat normal physiological state, causes its coefficient rising.Make behind the relative medicine ALT index correlation coefficient produce in various degree reduction and give respectively to organize, point out each administration group that ethanol is caused hepatic injury and all have to a certain degree preventive effect.Produce farthest reduction, i.e. preventive effect the best of whole part group with ALT index correlation coefficient behind the prescription in giving present embodiment.Hence one can see that single becomes in the grouping 6, and the 7-dimethoxy coumarin causes hepatic injury to ethanol and plays main therapeutical effect, is equipped with jasminoidin and can strengthens its effect, is equipped with chrysophanic acid again and can brings into play the merit that its assistant helps; Three medicine mutual reinforcements between are associated with, and the mutual-assistance is a usefulness, rise mutually each other to help the efficacy of a drug, and the merit that ethanol is caused treating liver injury significantly strengthens.
2, aspartate amino transferase (AST) index:
AST mainly is distributed in the hepatocyte, and the degree of its rising is consistent with the hepatocyte extent of damage, also is one of the most frequently used liver function index.It is disturbed to give behind the ethanol rat normal physiological state and AST index correlation coefficient, causes its coefficient to raise.Produced the trend that reduces in various degree and give each group of relative medicine with AST index phase relation number average, proved that each administration group causes hepatic injury to ethanol and all has to a certain degree preventive effect.Produce farthest reduction, i.e. preventive effect the best of whole part group with AST index correlation coefficient behind the prescription in giving present embodiment.
3, ethanol dehydrogenase (ADH) index:
ADH mainly is distributed in the hepatocyte, ethanol main metabolic place in vivo, ethanol dehydrogenase are to make one of topmost enzyme of alcohol oxidation, and the ethanol of about 80-90% is through the ADH oxidation, the degree of its rising is consistent with the hepatocyte extent of damage, also is one of the most frequently used liver function index.It is disturbed to give behind the ethanol rat normal physiological state and ADH index correlation coefficient, causes its coefficient to raise.Produced the trend that reduces in various degree and give each group of relative medicine with ADH index phase relation number average, proved that each administration group causes hepatic injury to ethanol and all has to a certain degree preventive effect.Produce farthest reduction, i.e. preventive effect the best of whole part group with ADH index correlation coefficient behind the prescription in giving present embodiment.
4, gamma glutamyl transpeptidase (index of γ-GT):
γ-GT distributes very wide in vivo, but therefore γ-the GT in the serum has stronger specificity mainly from liver.γ-GT raises and has reflected the hepatocyte extent of damage and cholestasis.It is disturbed to give behind the ethanol rat normal physiological state and γ-GT index correlation coefficient, causes its coefficient to raise.Produced the trend that reduces in various degree and give each group of relative medicine with γ-GT index phase relation number average, proved that each administration group causes hepatic injury to ethanol and all has to a certain degree preventive effect.Produce farthest reduction, i.e. preventive effect the best of whole part group with γ-GT index correlation coefficient behind the prescription in giving present embodiment.
5, triglyceride (TG) index:
It is disturbed to give behind the ethanol rat normal physiological state and TG index correlation coefficient, causes its coefficient to raise.Produced the trend that reduces in various degree and give each group of relative medicine with TG index phase relation number average, proved that each administration group causes hepatic injury to ethanol and all has to a certain degree preventive effect.Produce farthest reduction, i.e. preventive effect the best of whole part group with TG index correlation coefficient behind the prescription in giving present embodiment.
6, malonaldehyde (MDA) index:
MDA is the end product of lipid peroxidation, and pair cell has direct damaging action, the degree that how much has reflected body inner lipid peroxide injury of its content.Liver function damaged after rat gave ethanol, made rat normal physiological state and MDA index correlation coefficient disturbed, caused its coefficient to raise.Produced the trend that reduces in various degree and give each group of relative medicine with MDA index phase relation number average, illustrated that each administration group causes hepatic injury to ethanol and all has to a certain degree preventive effect.Produce farthest rising, i.e. preventive effect the best of whole part group with MDA index correlation coefficient behind the prescription in giving present embodiment.
7, glutathion peroxidase (GSH-Px) index:
GSH-Px is that the endogenous or exogenous a kind of protective enzyme of the lipid peroxidation of generation of inducing of body antagonism is.GSH-Px avoids playing pivotal role in the radical damage process at the harmful peroxidating metabolite protection of removing cell.The vigor of glutathion peroxidase can take place obviously to raise or downward modulation under some pathological conditions.It is disturbed to give behind the ethanol rat normal physiological state and GSH-Px index correlation coefficient γ, causes its coefficient to reduce.Produced trend of rising in various degree and give each group of relative medicine with GSH-Px index phase relation number average, illustrated that each administration group causes hepatic injury to ethanol and all has to a certain degree preventive effect.Produce farthest rising, i.e. preventive effect the best of whole part group with GSH-Px index correlation coefficient behind the prescription in giving present embodiment.
8, total protein (TP) index:
TP is the index of reflection hepatocyte albumen anabolism function.Because total protein all is synthetic by liver, in case the liver complex functionality descends, above index decreases at blood middle concentration, and its reduction degree and the liver complex functionality extent of damage are proportionate.It is disturbed to give behind the ethanol rat normal physiological state and TP index correlation coefficient γ, causes its coefficient to raise.Produced the trend that reduces in various degree and give each group of relative medicine with TP index phase relation number average, illustrated that each administration group causes hepatic injury to ethanol and all has to a certain degree preventive effect.Produce farthest reduction, i.e. preventive effect the best of whole part group with TP index correlation coefficient behind the prescription in giving present embodiment.
The specific embodiment two: present embodiment and the specific embodiment one different be the treatment alcoholic liver injury combination of active principles by ratio of quality and the number of copies by 16 parts 6,7-dimethoxy coumarin, 7 parts jasminoidin and 4 parts chrysophanic acid are formed.Other is identical with the specific embodiment one.
The specific embodiment three: present embodiment and the specific embodiment one different be the treatment alcoholic liver injury combination of active principles by ratio of quality and the number of copies by 20 parts 6,7-dimethoxy coumarin, 11 parts jasminoidin and 8 parts chrysophanic acid are formed.Other is identical with the specific embodiment one.
The specific embodiment four: present embodiment and the specific embodiment one different be the treatment alcoholic liver injury combination of active principles by ratio of quality and the number of copies by 17～19 parts 6,7-dimethoxy coumarin, 8～10 parts jasminoidin and 5～7 parts chrysophanic acid are formed.Other is identical with the specific embodiment one.
The specific embodiment five: present embodiment and the specific embodiment one different be the treatment alcoholic liver injury combination of active principles by ratio of quality and the number of copies by 18 parts 6,7-dimethoxy coumarin, 9 parts jasminoidin and 6 parts chrysophanic acid are formed.Other is identical with the specific embodiment one.
The combination of active principles of treatment alcoholic liver injury in the present embodiment, effect (see figure 1) to ALT, AST, ADH, γ-GT, TG, MDA, GSH-Px and TP, compare with Herba Artemisiae Scopariae Decoction lyophilized powder (YCHT) (see figure 2), as can be known, the therapeutic effect of the combination of active principles of treatment alcoholic liver injury is identical with YCHT in the present embodiment, all can play the effect of treatment alcoholic liver injury.
Claims (3)
1. combination of active principles for the treatment of alcoholic liver injury, the combination of active principles that it is characterized in that treating alcoholic liver injury by ratio of quality and the number of copies by 16～20 parts 6,7-dimethoxy coumarin, 7～11 parts jasminoidin and 4～8 parts chrysophanic acid are formed.
2. a kind of combination of active principles for the treatment of alcoholic liver injury according to claim 1, the combination of active principles that it is characterized in that treating alcoholic liver injury by ratio of quality and the number of copies by 17～19 parts 6,7-dimethoxy coumarin, 8～10 parts jasminoidin and 5～7 parts chrysophanic acid are formed.
3. a kind of combination of active principles for the treatment of alcoholic liver injury according to claim 1, the combination of active principles that it is characterized in that treating alcoholic liver injury by ratio of quality and the number of copies by 18 parts 6,7-dimethoxy coumarin, 9 parts jasminoidin and 6 parts chrysophanic acid are formed.
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| CN201010611136A CN102028701B (en) | 2010-12-29 | 2010-12-29 | Active ingredient composition for treating alcoholic liver injury |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103690553A (en) * | 2013-12-19 | 2014-04-02 | 上海市公共卫生临床中心 | Medicinal composition for reducing hepatocellular jaundice and application thereof |
| CN104688756A (en) * | 2013-12-09 | 2015-06-10 | 中国药科大学 | Pharmaceutical composition and its use in preparation of drug for treating alcoholic liver injury |
| CN110354119A (en) * | 2018-03-26 | 2019-10-22 | 中国农业大学 | Application of the glycycoumarin in the drug of preparation prevention and/or medicine physical property hepatic injury |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101371882A (en) * | 2007-08-24 | 2009-02-25 | 曾雄辉 | Method for preparing Artemisia capillaris decoction formulation |
| CN101904839A (en) * | 2010-08-06 | 2010-12-08 | 中国人民解放军第二军医大学 | Application of imperatorin in preparing medicament for preventing and treating hepatitis or liver injury |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101371882A (en) * | 2007-08-24 | 2009-02-25 | 曾雄辉 | Method for preparing Artemisia capillaris decoction formulation |
| CN101904839A (en) * | 2010-08-06 | 2010-12-08 | 中国人民解放军第二军医大学 | Application of imperatorin in preparing medicament for preventing and treating hepatitis or liver injury |
Non-Patent Citations (1)
| Title |
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| 《中国中药杂志》 20100531 王喜军等 基于药物代谢组学的方剂配伍规律及配伍科学价值揭示 1346-1348 1-3 第35卷, 第10期 2 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104688756A (en) * | 2013-12-09 | 2015-06-10 | 中国药科大学 | Pharmaceutical composition and its use in preparation of drug for treating alcoholic liver injury |
| CN103690553A (en) * | 2013-12-19 | 2014-04-02 | 上海市公共卫生临床中心 | Medicinal composition for reducing hepatocellular jaundice and application thereof |
| CN103690553B (en) * | 2013-12-19 | 2016-03-23 | 上海市公共卫生临床中心 | A kind of pharmaceutical composition and application thereof of moving back hepatocellular jaundice |
| CN110354119A (en) * | 2018-03-26 | 2019-10-22 | 中国农业大学 | Application of the glycycoumarin in the drug of preparation prevention and/or medicine physical property hepatic injury |
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